TDMS Study 05077-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
FIREMASTER FF-1 POLYBROMINATED BIPHENYL
NTP Experiment-Test: 05077-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
Facility: Battelle Columbus Laboratory
Chemical CAS #: 67774327
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50 50
Early Deaths
Moribund Sacrifice 10 10 9 12 8 10
Natural Death 1 1 2 3 2
Survivors
Terminal Sacrifice 40 39 39 36 39 38
Moribund Sacrifice 1
Animals Examined Microscopically 50 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (10) (11) (13) (10) (12)
Leiomyosarcoma 1 (10%)
Intestine Small, Duodenum (50) (12) (11) (13) (10) (12)
Schwannoma Malignant 1 (8%)
Serosa, Adenocarcinoma, Metastatic, Uterus 1 (8%)
Liver (50) (50) (50) (50) (50) (50)
Hepatocellular Carcinoma 2 (4%) 1 (2%) 7 (14%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 2 (4%) 6 (12%) 12 (24%) 15 (30%)
Hepatocellular Adenoma, Multiple 1 (2%) 4 (8%) 10 (20%) 20 (40%)
Hepatocholangiocarcinoma 1 (2%)
Mesentery (2) (1) (1) (1) (1) (4)
Hepatocellular Carcinoma, Metastatic, Liver 1 (25%)
Pancreas (49) (12) (11) (13) (9) (12)
Adenocarcinoma, Metastatic, Uterus 1 (8%)
Stomach (50) (49) (50) (50) (50) (50)
Serosa, Adenocarcinoma, Metastatic, Uterus 1 (2%)
Stomach, Forestomach (50) (49) (50) (50) (50) (49)
Squamous Cell Carcinoma 1 (2%)
Stomach, Glandular (50) (48) (50) (50) (50) (50)
Sarcoma 1 (2%)
Tongue (1) (1) (1) (1) (1)
Carcinoma, Metastatic, Zymbal's Gland 1 (100%)
Squamous Cell Carcinoma 1 (100%) 1 (100%)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (11) (12) (14) (11) (12)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (11) (12) (14) (9) (12)
Capsule, Adenocarcinoma, Metastatic, Uterus 1 (9%)
Adrenal Gland, Cortex (50) (10) (12) (14) (9) (12)
Adenoma 1 (2%) 1 (10%)
Adrenal Gland, Medulla (48) (10) (12) (13) (9) (12)
Pheochromocytoma Malignant 1 (8%)
Pheochromocytoma Benign 2 (4%) 1 (8%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (12) (11) (13) (9) (12)
Carcinoma 1 (8%)
Parathyroid Gland (46) (9) (11) (14) (9) (10)
Adenoma 2 (4%)
Pituitary Gland (50) (34) (27) (29) (28) (27)
Pars Distalis, Adenoma 21 (42%) 19 (56%) 19 (70%) 18 (62%) 12 (43%) 12 (44%)
Pars Intermedia, Adenoma 2 (7%) 1 (4%)
Thyroid Gland (50) (12) (15) (14) (10) (13)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 10 (20%) 4 (33%) 4 (27%) 3 (21%) 2 (15%)
C-Cell, Adenoma, Moderate 1 (8%)
C-Cell, Carcinoma 1 (8%) 2 (13%) 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Liposarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (15) (12) (16) (10) (13)
Adenoma 3 (6%) 1 (7%) 1 (6%) 1 (8%)
Bilateral, Adenoma 1 (7%)
Ovary (50) (23) (19) (22) (14) (20)
Granulosa-Theca Tumor Malignant 1 (5%)
Periovarian Tissue, Adenocarcinoma,
Metastatic, Uterus 1 (4%)
Periovarian Tissue, Leiomyoma 1 (5%)
Uterus (50) (17) (18) (18) (21) (20)
Adenocarcinoma 2 (4%) 1 (6%) 2 (11%)
Polyp Stromal 7 (14%) 4 (24%) 2 (11%) 3 (17%) 6 (29%) 4 (20%)
Page 3
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Sarcoma Stromal 1 (6%)
Schwannoma Malignant 1 (2%)
Epithelium, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (11) (11) (13) (9) (11)
Lymph Node (50) (11) (11) (14) (12) (12)
Mediastinal, Adenocarcinoma, Metastatic,
Uterus 1 (9%)
Lymph Node, Mesenteric (4) (2) (3) (1) (1) (3)
Adenocarcinoma, Metastatic, Uterus 1 (50%)
Spleen (50) (50) (50) (50) (49) (49)
Thymus (44) (9) (11) (11) (9) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (16) (13) (21) (16) (11)
Adenoma 1 (6%)
Carcinoma 1 (6%)
Fibroadenoma 4 (8%) 7 (44%) 2 (15%) 10 (48%) 7 (44%) 2 (18%)
Fibroadenoma, Multiple 1 (8%) 1 (5%)
Skin (50) (11) (12) (13) (11) (14)
Basal Cell Adenoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (9%)
Subcutaneous Tissue, Fibrosarcoma 1 (8%) 3 (21%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (11) (11) (14) (10) (12)
Astrocytoma Malignant 2 (4%) 1 (7%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (11) (11) (14) (9) (11)
Adenocarcinoma, Metastatic, Uterus 1 (9%) 1 (9%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (9%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (11) (11) (14) (11) (12)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50) *(50)
Leukemia Mononuclear 14 (28%) 13 (26%) 20 (40%) 22 (44%) 17 (34%) 27 (54%)
Lymphoma Malignant Lymphocytic 1 (2%)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 40 37 35 42 41 49
Total Primary Neoplasms 77 58 61 80 70 96
Total Animals with Benign Neoplasms 34 30 25 33 34 41
Total Benign Neoplasms 56 40 33 49 49 56
Total Animals with Malignant Neoplasms 20 16 25 28 20 31
Total Malignant Neoplasms 21 18 28 31 21 40
Total Animals with Metastatic Neoplasms 1 1 2
Total Metastatic Neoplasm 8 1 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Natural Death 5 2
Moribund Sacrifice 10 15
Survivors
Terminal Sacrifice 34 32
Natural Death 1 1
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (50)
Hepatocellular Carcinoma 4 (8%) 16 (32%)
Hepatocellular Carcinoma, Multiple 6 (12%)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Hepatocellular Adenoma, Multiple 37 (74%) 44 (88%)
Hepatocholangiocarcinoma 1 (2%)
Pancreas (50) (50)
Stomach, Forestomach (48) (50)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Adenoma 1 (2%)
Bilateral, Adenoma 1 (2%)
Adrenal Gland, Medulla (49) (49)
Pituitary Gland (50) (50)
Pars Distalis, Adenoma 2 (4%) 5 (10%)
Pars Distalis, Adenoma, Mild 1 (2%)
Pars Distalis, Adenoma, Moderate 1 (2%)
Thyroid Gland (48) (48)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 2 (4%) 7 (15%)
C-Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (46)
Carcinoma 1 (2%) 1 (2%)
Ovary (48) (49)
Leiomyosarcoma 1 (2%)
Uterus (49) (50)
Adenocarcinoma 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 7 (14%) 4 (8%)
Sarcoma Stromal 1 (2%)
Vagina (2)
Leiomyosarcoma 1 (50%)
Polyp 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (47)
Lymph Node (49) (47)
Lymph Node, Mesenteric (5)
Spleen (50) (50)
Thymus (41) (42)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (48)
Adenoma 1 (2%)
Fibroadenoma 1 (2%) 4 (8%)
Fibroadenoma, Multiple 1 (2%)
Skin (49) (50)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (47) (50)
Alveolar/Bronchiolar Adenoma 2 (4%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Squamous Cell Carcinoma, Multiple,
Metastatic, Uncertain Primary Site 1 (2%)
Squamous Cell Carcinoma, Metastatic,
Clitoral Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (49) (50)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Mononuclear 23 (46%) 25 (50%)
Lymphoma Malignant Histiocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 47 50
Total Primary Neoplasms 90 125
Total Animals with Benign Neoplasms 41 46
Total Benign Neoplasms 59 71
Total Animals with Malignant Neoplasms 27 36
Total Malignant Neoplasms 31 54
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 2 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50 50
Early Deaths
Natural Death 5 4 1 6 5 4
Moribund Sacrifice 16 16 15 21 25 26
Survivors
Natural Death 1
Terminal Sacrifice 29 29 34 22 19 19
Moribund Sacrifice 1 1 1
Animals Examined Microscopically 50 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (20) (16) (26) (30) (29)
Intestine Large, Colon (49) (21) (16) (27) (31) (30)
Intestine Large, Rectum (49) (21) (16) (27) (30) (30)
Intestine Small, Duodenum (48) (21) (16) (27) (31) (30)
Intestine Small, Ileum (49) (19) (16) (28) (29) (29)
Adenocarcinoma 1 (2%) 1 (4%)
Intestine Small, Jejunum (49) (20) (16) (27) (30) (30)
Adenocarcinoma 1 (4%)
Liver (50) (50) (50) (49) (50) (50)
Adenocarcinoma, Metastatic, Prostate 1 (2%)
Adenocarcinoma, Metastatic, Intestine Small 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Hepatocellular Adenoma 1 (2%) 4 (8%) 3 (6%) 4 (8%) 6 (12%) 10 (20%)
Hepatocellular Adenoma, Multiple 1 (2%) 2 (4%) 6 (12%) 7 (14%) 6 (12%)
Mesentery (6) (3) (1) (2)
Adenocarcinoma, Metastatic, Prostate 1 (17%)
Lipoma 1 (50%)
Pancreas (49) (21) (16) (27) (32) (31)
Acinus, Adenoma 1 (2%) 1 (6%) 1 (4%) 3 (9%) 1 (3%)
Salivary Glands (50) (21) (16) (27) (30) (30)
Schwannoma Malignant 1 (2%)
Stomach, Forestomach (50) (49) (48) (49) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Stomach, Glandular (50) (48) (48) (48) (50) (49)
Carcinoid Tumor Malignant 1 (2%)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
Tooth (1)
Gingiva, Squamous Cell Carcinoma 1 (100%)
Page 11
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (21) (16) (27) (31) (31)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (21) (15) (28) (31) (30)
Adrenal Gland, Medulla (49) (22) (16) (29) (32) (30)
Pheochromocytoma Malignant 1 (2%) 1 (3%) 1 (3%) 1 (3%)
Pheochromocytoma Complex 1 (5%) 1 (6%)
Pheochromocytoma Benign 11 (22%) 4 (18%) 1 (6%) 1 (3%) 2 (6%) 3 (10%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (49) (21) (16) (27) (31) (30)
Adenoma 4 (8%) 1 (5%) 1 (4%) 1 (3%)
Carcinoma 3 (6%)
Parathyroid Gland (43) (21) (16) (27) (31) (29)
Adenoma 1 (4%) 2 (7%)
Pituitary Gland (50) (27) (22) (32) (30) (34)
Pars Distalis, Adenoma 13 (26%) 7 (26%) 9 (41%) 11 (34%) 9 (30%) 11 (32%)
Pars Distalis, Adenoma, Multiple 1 (3%)
Pars Nervosa, Astrocytoma Malignant,
Metastatic, Brain 1 (4%)
Thyroid Gland (49) (23) (17) (28) (31) (30)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (4%) 1 (4%)
Bilateral, Follicular Cell, Adenoma 1 (3%)
C-Cell, Adenoma 16 (33%) 3 (13%) 4 (24%) 8 (29%) 3 (10%) 8 (27%)
C-Cell, Carcinoma 1 (2%) 2 (9%) 1 (6%) 3 (10%)
Follicular Cell, Adenoma 1 (2%) 1 (4%) 2 (6%)
Follicular Cell, Carcinoma 2 (9%) 1 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Chordoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (20) (16) (28) (30) (30)
Adenocarcinoma, Metastatic, Prostate 1 (5%)
Preputial Gland (47) (25) (20) (32) (34) (32)
Adenoma 4 (9%) 1 (4%) 1 (5%) 1 (3%)
Carcinoma 3 (6%) 3 (12%) 3 (15%) 4 (13%) 4 (12%) 2 (6%)
Duct, Squamous Cell Papilloma 1 (2%)
Page 12
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Prostate (50) (21) (16) (28) (30) (31)
Adenocarcinoma 1 (5%)
Testes (50) (49) (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 43 (86%) 41 (84%) 43 (86%) 45 (90%) 37 (74%) 42 (84%)
Interstitial Cell, Adenoma 6 (12%) 5 (10%) 4 (8%) 4 (8%) 9 (18%) 5 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (21) (15) (27) (31) (30)
Lymph Node (50) (23) (18) (27) (33) (31)
Mediastinal, Adenocarcinoma, Metastatic,
Prostate 1 (4%)
Mediastinal, Fibrosarcoma, Metastatic, Skin 1 (3%)
Lymph Node, Mesenteric (2) (3) (2) (9) (8) (4)
Adenocarcinoma, Metastatic, Prostate 1 (33%)
Fibrosarcoma, Metastatic, Skin 1 (50%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (50%)
Spleen (50) (50) (49) (49) (50) (50)
Fibrosarcoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Thymus (47) (17) (15) (22) (24) (27)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (39) (14) (14) (23) (20) (18)
Fibroadenoma 1 (3%) 2 (14%) 4 (17%)
Skin (50) (26) (22) (31) (32) (32)
Basosquamous Tumor Benign 1 (3%)
Fibroma 1 (3%)
Keratoacanthoma 2 (4%) 1 (5%)
Squamous Cell Papilloma 1 (2%) 1 (3%)
Trichoepithelioma 1 (3%) 1 (3%)
Sebaceous Gland, Adenoma 1 (5%)
Subcutaneous Tissue, Fibroma 5 (10%) 2 (8%) 6 (27%) 1 (3%) 4 (13%) 2 (6%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 4 (15%) 3 (14%) 2 (6%) 1 (3%) 1 (3%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (3%)
____________________________________________________________________________________________________________________________________
Page 13
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (21) (16) (28) (31) (31)
Femur, Hemangiosarcoma 1 (3%)
Femur, Osteosarcoma 1 (6%)
Lumbar, Osteosarcoma 1 (3%)
Rib, Osteosarcoma 1 (5%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (21) (16) (29) (31) (31)
Astrocytoma Malignant 1 (5%)
Glioma Malignant 1 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (21) (17) (28) (32) (31)
Adenocarcinoma, Metastatic, Prostate 1 (5%)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (12%) 1 (4%) 1 (3%)
Alveolar/Bronchiolar Carcinoma 1 (6%) 1 (4%) 1 (3%)
Carcinoma Adenosquamous 1 (3%) 1 (3%)
Chordoma, Metastatic, Uncertain Primary Site 1 (6%)
Fibrosarcoma, Metastatic, Skin 1 (6%) 1 (3%)
Osteosarcoma, Metastatic, Bone 1 (6%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Pheochromocytoma Complex, Metastatic,
Adrenal Gland 1 (6%)
Mediastinum, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (6%)
Nose (50) (21) (16) (27) (31) (30)
Submucosa, Glands, Adenocarcinoma 2 (10%)
Trachea (50) (21) (16) (27) (31) (31)
Peritracheal Tissue, Fibrosarcoma,
Metastatic, Skin 1 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 14
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (24) (20) (32) (32) (37)
Medulla, Sarcoma 1 (2%)
Renal Tubule, Adenoma 1 (4%) 2 (6%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (49) (20) (17) (27) (31) (30)
Adenocarcinoma, Metastatic, Prostate 1 (5%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50) *(50) *(50)
Leukemia Mononuclear 25 (50%) 32 (64%) 32 (64%) 33 (66%) 41 (82%) 37 (74%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%)
Mesothelioma Benign 1 (2%) 1 (2%)
Mesothelioma Malignant 1 (2%) 5 (10%) 2 (4%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 15
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 3 PPM 10 PPM 10 PPM 10 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 50 50 50
Total Primary Neoplasms 157 130 124 145 144 144
Total Animals with Benign Neoplasms 50 47 48 50 47 48
Total Benign Neoplasms 116 72 80 94 88 95
Total Animals with Malignant Neoplasms 34 42 39 41 43 41
Total Malignant Neoplasms 41 58 44 51 56 49
Total Animals with Metastatic Neoplasms 2 3 5 1 1
Total Metastatic Neoplasm 4 9 6 1 3
Total Animals with Malignant Neoplasms 1 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 16
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Moribund Sacrifice 23 24
Natural Death 3 7
Survivors
Moribund Sacrifice 1 1
Terminal Sacrifice 23 18
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (48) (48)
Leiomyoma 2 (4%)
Leiomyosarcoma 1 (2%)
Leiomyosarcoma, Metastatic, Mesentery 1 (2%)
Liver (50) (50)
Hepatocellular Carcinoma 12 (24%) 13 (26%)
Hepatocellular Carcinoma, Multiple 7 (14%) 10 (20%)
Hepatocellular Adenoma 2 (4%) 3 (6%)
Hepatocellular Adenoma, Multiple 36 (72%) 35 (70%)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%)
Mesentery (5) (2)
Fibrosarcoma 1 (20%)
Hemangiosarcoma 1 (50%)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (20%)
Pancreas (49) (50)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%)
Stomach, Forestomach (50) (50)
Squamous Cell Carcinoma 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (50) (50)
Pheochromocytoma Benign 2 (4%) 3 (6%)
Page 17
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Islets, Pancreatic (49) (50)
Adenoma 2 (4%) 1 (2%)
Parathyroid Gland (49) (47)
Adenoma 2 (4%)
Pituitary Gland (48) (49)
Pars Distalis, Adenoma 4 (8%) 9 (18%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (49)
C-Cell, Adenoma 8 (16%) 11 (22%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50)
Preputial Gland (44) (49)
Adenoma 1 (2%) 1 (2%)
Carcinoma 5 (10%)
Testes (50) (50)
Bilateral, Interstitial Cell, Adenoma 37 (74%) 36 (72%)
Interstitial Cell, Adenoma 9 (18%) 10 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Lymph Node (49) (49)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (2%)
Lymph Node, Mesenteric (4) (2)
Spleen (50) (50)
Osteosarcoma, Metastatic, Bone 1 (2%)
Thymus (40) (28)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibroma 2 (4%) 3 (6%)
Page 18
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Fibroma, Multiple 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Neurofibroma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Femur, Osteosarcoma 1 (2%)
Skeletal Muscle (1)
Rhabdomyosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49)
Alveolar/Bronchiolar Adenoma 3 (6%) 1 (2%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (6%)
Squamous Cell Carcinoma, Metastatic, Stomach 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Renal Tubule, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Mononuclear 31 (62%) 37 (74%)
Mesothelioma Malignant 1 (2%)
* Number of animals with any tissue examined microscopically
Page 19
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50)
____________________________________________________________________________________________________________________________________
Page 20
NTP Experiment-Test: 05077-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC FIREMASTER FF-1 POLYBROMINATED BIPHENYL Date: 09/10/94
Route: DOSED FEED Time: 05:22:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 30 PPM 30 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50
Total Primary Neoplasms 171 196
Total Animals with Benign Neoplasms 49 49
Total Benign Neoplasms 113 123
Total Animals with Malignant Neoplasms 42 47
Total Malignant Neoplasms 58 73
Total Animals with Metastatic Neoplasms 3 4
Total Metastatic Neoplasm 6 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 21
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