TDMS Study 05077-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus FIREMASTER FF-1 POLYBROMINATED BIPHENYL DATE: 09/10/94
EXPERIMENT: 05077 TEST: 01 TIME: 05:41:47
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 53634B
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 67774327
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus FIREMASTER FF-1 POLYBROMINATED BIPHENYL DATE: 09/10/94
EXPERIMENT: 05077 TEST: 01 TIME: 05:41:47
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 53634B
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 67774327
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus FIREMASTER FF-1 POLYBROMINATED BIPHENYL DATE: 09/10/94
EXPERIMENT: 05077 TEST: 01 TIME: 05:41:47
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 53634B
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 67774327
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF FIREMASTER FF-1 POLYBROMINATED BIPHEN
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Carcinoma
Carcinoma or Adenoma
Intestine Small Leiomyoma
Islets, Pancreatic Carcinoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Carcinoma
Pancreas Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Skin: Subcutaneous Tissue Fibrosarcoma
Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
Stomach, Forestomach Squamous Cell Carcinoma
Testes Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Mesothelioma Benign, Malignant, NOS
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus FIREMASTER FF-1 POLYBROMINATED BIPHENYL DATE: 09/10/94
EXPERIMENT: 05077 TEST: 01 TIME: 05:41:47
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-82151 ROUTE: DOSED FEED NTP C#: 53634B
PATHOLOGIST: R. PERSING S. EUSTIS CAS: 67774327
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF FIREMASTER FF-1 POLYBROMINATED BIPHEN
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma Malignant
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin: Subcutaneous Tissue Lipoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/71 (0%) 0/15 (0%) 0/89 (0%) 1/100 (1%) | 2/60 (3%) 0/12 (0%) 0/35 (0%) 2/100 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 1.6% | 3.7% 0.0% 0.0% 2.9% |
|TERMINAL (d) | 0/31 (0%) 0/0 0/4 (0%) 0/43 (0%) | 1/40 (3%) 0/2 (0%) 0/1 (0%) 2/68 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 679 | 707 --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.210 (e) (e) P=0.468 | P=0.549N P=0.582N P=0.404N P=0.558N |
|INCIDENTAL TUMOR | P=0.244 (e) (e) P=0.530 | P=0.503N P=0.608N P=0.399N P=0.496N |
|LOGISTIC REGRESSION | P=0.332 (e) (e) P=0.568 | P=0.490N P=0.706N P=0.552N P=0.485N |
|COCHRAN-ARMITAGE | P=0.324 | P=0.567N |
|FISHER EXACT | (e) (e) P=0.585 | P=0.692N P=0.396N P=0.482N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/71 (23%) 1/16 (6%) 6/91 (7%) 5/100 (5%) | 3/58 (5%) 1/12 (8%) 0/34 (0%) 0/98 (0%) |
|ADJUSTED (b) | 32.3% 0.0% 5.6% 11.6% | 7.9% 2.4% 0.0% 0.0% |
|TERMINAL (d) | 7/30 (23%) 0/0 0/5 (0%) 5/43 (12%) | 3/38 (8%) 0/2 (0%) 0/1 (0%) 0/66 (0%) |
|FIRST INCIDENCE (DAYS) | 580 679 455 727 (T) | 729 (T) 727 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.008N** P=0.091N P=0.084N P=0.005N** | P=0.023N* P=0.494 P=0.944N P=0.045N* |
|INCIDENTAL TUMOR | P=0.002N** P=0.163N P=0.008N** P=0.001N** | P=0.019N* P=0.475 P=0.944N P=0.045N* |
|LOGISTIC REGRESSION | P=0.002N** P=0.217N P=0.008N** P<0.001N** | P=0.016N* P=0.384 P=0.944N P=0.045N* |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.025N* |
|FISHER EXACT | P=0.124N P=0.003N** P<0.001N** | P=0.537 P=0.246N P=0.050N* |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/71 (1%) 0/16 (0%) 3/91 (3%) 0/100 (0%) | 0/58 (0%) 1/12 (8%) 0/34 (0%) 0/98 (0%) |
|ADJUSTED (b) | 1.5% 0.0% 40.7% 0.0% | 0.0% 50.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/0 2/5 (40%) 0/43 (0%) | 0/38 (0%) 1/2 (50%) 0/1 (0%) 0/66 (0%) |
|FIRST INCIDENCE (DAYS) | 706 --- 689 --- | --- 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.276N P=0.612N P=0.093 P=0.556N | P=0.348N P=0.019 * (e) (e) |
|INCIDENTAL TUMOR | P=0.232N P=0.690N P=0.138 P=0.478N | P=0.348N P=0.019 * (e) (e) |
|LOGISTIC REGRESSION | P=0.210N P=0.875N P=0.136 P=0.434N | P=0.348N P=0.019 * (e) (e) |
|COCHRAN-ARMITAGE | P=0.246N | P=0.400N |
|FISHER EXACT | P=0.816N P=0.409 P=0.415N | P=0.171 (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 17/71 (24%) 2/16 (13%) 9/91 (10%) 5/100 (5%) | 3/58 (5%) 2/12 (17%) 0/34 (0%) 0/98 (0%) |
|ADJUSTED (b) | 33.1% 0.0% 44.0% 11.6% | 7.9% 51.2% 0.0% 0.0% |
|TERMINAL (d) | 7/30 (23%) 0/0 2/5 (40%) 5/43 (12%) | 3/38 (8%) 1/2 (50%) 0/1 (0%) 0/66 (0%) |
|FIRST INCIDENCE (DAYS) | 580 487 455 727 (T) | 729 (T) 727 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003N** P=0.153N P=0.283N P=0.003N** | P=0.011N* P=0.065 P=0.944N P=0.045N* |
|INCIDENTAL TUMOR | P<0.001N** P=0.261N P=0.059N P<0.001N** | P=0.009N** P=0.057 P=0.944N P=0.045N* |
|LOGISTIC REGRESSION | P<0.001N** P=0.329N P=0.041N* P<0.001N** | P=0.008N** P=0.027 * P=0.944N P=0.045N* |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.014N* |
|FISHER EXACT | P=0.261N P=0.014N* P<0.001N** | P=0.201 P=0.246N P=0.050N* |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Brain |
| Astrocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/71 (1%) 0/16 (0%) 0/91 (0%) 0/100 (0%) | 2/61 (3%) 0/11 (0%) 1/36 (3%) 0/99 (0%) |
|ADJUSTED (b) | 1.1% 0.0% 0.0% 0.0% | 3.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/0 0/4 (0%) 0/43 (0%) | 1/40 (3%) 0/1 (0%) 0/0 0/67 (0%) |
|FIRST INCIDENCE (DAYS) | 580 --- --- --- | 656 --- 502 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.445N P=0.632N P=0.429N P=0.502N | P=0.158N P=0.611N P=0.674N P=0.187N |
|INCIDENTAL TUMOR | P=0.338N P=0.739N P=0.326N P=0.362N | P=0.121N P=0.631N P=0.645N P=0.138N |
|LOGISTIC REGRESSION | P=0.392N P=0.719N P=0.397N P=0.449N | P=0.124N P=0.680N P=0.598N P=0.141N |
|COCHRAN-ARMITAGE | P=0.366N | P=0.109N |
|FISHER EXACT | P=0.816N P=0.438N P=0.415N | P=0.716N P=0.691N P=0.144N |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/71 (1%) 0/16 (0%) 1/91 (1%) 1/100 (1%) | 2/61 (3%) 0/11 (0%) 1/36 (3%) 0/99 (0%) |
|ADJUSTED (b) | 1.1% 0.0% 1.0% 2.2% | 3.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/0 0/4 (0%) 0/43 (0%) | 1/40 (3%) 0/1 (0%) 0/0 0/67 (0%) |
|FIRST INCIDENCE (DAYS) | 580 --- 676 718 | 656 --- 502 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.556 P=0.632N P=0.690N P=0.732 | P=0.158N P=0.611N P=0.674N P=0.187N |
|INCIDENTAL TUMOR | P=0.682 P=0.739N P=0.582N P=0.672N | P=0.121N P=0.631N P=0.645N P=0.138N |
|LOGISTIC REGRESSION | P=0.636N P=0.719N P=0.676N P=0.684N | P=0.124N P=0.680N P=0.598N P=0.141N |
|COCHRAN-ARMITAGE | P=0.633N | P=0.109N |
|FISHER EXACT | P=0.816N P=0.686N P=0.659N | P=0.716N P=0.691N P=0.144N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/72 (7%) 1/20 (5%) 1/98 (1%) 2/93 (2%) | 5/65 (8%) 0/12 (0%) 2/39 (5%) 0/93 (0%) |
|ADJUSTED (b) | 13.5% 25.0% 7.7% 2.9% | 11.1% 0.0% 33.8% 0.0% |
|TERMINAL (d) | 4/33 (12%) 1/4 (25%) 1/13 (8%) 0/42 (0%) | 5/45 (11%) 0/2 (0%) 1/3 (33%) 0/65 (0%) |
|FIRST INCIDENCE (DAYS) | 710 727 (T) 727 (T) 631 | 729 (T) --- 615 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145N P=0.692 P=0.343N P=0.201N | P=0.010N* P=0.747N P=0.239 P=0.011N* |
|INCIDENTAL TUMOR | P=0.114N P=0.659 P=0.296N P=0.141N | P=0.009N** P=0.747N P=0.281 P=0.011N* |
|LOGISTIC REGRESSION | P=0.125N P=0.685 P=0.295N P=0.137N | P=0.011N* P=0.747N P=0.623 P=0.011N* |
|COCHRAN-ARMITAGE | P=0.140N | P=0.014N* |
|FISHER EXACT | P=0.612N P=0.050N* P=0.131N | P=0.418N P=0.473N P=0.011N* |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/72 (8%) 3/20 (15%) 10/98 (10%) 5/93 (5%) | 0/65 (0%) 0/12 (0%) 0/39 (0%) 2/93 (2%) |
|ADJUSTED (b) | 16.6% 28.6% 34.8% 7.9% | 0.0% 0.0% 0.0% 3.1% |
|TERMINAL (d) | 5/33 (15%) 1/4 (25%) 4/13 (31%) 1/42 (2%) | 0/45 (0%) 0/2 (0%) 0/3 (0%) 2/65 (3%) |
|FIRST INCIDENCE (DAYS) | 716 676 582 462 | --- --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.248N P=0.243 P=0.047 * P=0.456N | P=0.226 (e) (e) P=0.323 |
|INCIDENTAL TUMOR | P=0.148N P=0.169 P=0.097 P=0.334N | P=0.226 (e) (e) P=0.323 |
|LOGISTIC REGRESSION | P=0.152N P=0.184 P=0.208 P=0.333N | P=0.226 (e) (e) P=0.323 |
|COCHRAN-ARMITAGE | P=0.164N | P=0.156 |
|FISHER EXACT | P=0.304 P=0.446 P=0.327N | (e) (e) P=0.345 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/72 (15%) 4/20 (20%) 11/98 (11%) 7/93 (8%) | 5/65 (8%) 0/12 (0%) 2/39 (5%) 2/93 (2%) |
|ADJUSTED (b) | 29.6% 52.4% 42.0% 10.6% | 11.1% 0.0% 33.8% 3.1% |
|TERMINAL (d) | 9/33 (27%) 2/4 (50%) 5/13 (38%) 1/42 (2%) | 5/45 (11%) 0/2 (0%) 1/3 (33%) 2/65 (3%) |
|FIRST INCIDENCE (DAYS) | 710 676 582 462 | 729 (T) --- 615 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.092N P=0.256 P=0.150 P=0.193N | P=0.076N P=0.747N P=0.239 P=0.098N |
|INCIDENTAL TUMOR | P=0.041N* P=0.171 P=0.273 P=0.099N | P=0.070N P=0.747N P=0.281 P=0.098N |
|LOGISTIC REGRESSION | P=0.047N* P=0.208 P=0.507 P=0.096N | P=0.083N P=0.747N P=0.623 P=0.098N |
|COCHRAN-ARMITAGE | P=0.056N | P=0.111N |
|FISHER EXACT | P=0.418 P=0.291N P=0.092N | P=0.418N P=0.473N P=0.103N |
|=================================================================================================================================|
| |
|Intestine Small |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 1.7% 0.0% 3.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/59 (2%) 0/34 (0%) 1/63 (2%) 0/43 (0%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 707 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.486N P=0.610N P=0.529 P=0.563N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.448N P=0.610N P=0.589 P=0.563N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.460N P=0.610N P=0.566 P=0.563N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.402N | (e) |
|FISHER EXACT | P=0.667N P=0.649 P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Leiomyoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 2/100 (2%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 3.5% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 1/43 (2%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 603 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.038 * (e) (e) P=0.205 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.061 (e) (e) P=0.273 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.049 * (e) (e) P=0.248 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.047 * | (e) |
|FISHER EXACT | (e) (e) P=0.249 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/70 (7%) 0/16 (0%) 2/88 (2%) 3/99 (3%) | 0/61 (0%) 0/11 (0%) 0/34 (0%) 0/99 (0%) |
|ADJUSTED (b) | 12.1% 0.0% 1.7% 6.1% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/30 (10%) 0/0 0/3 (0%) 2/43 (5%) | 0/40 (0%) 0/1 (0%) 0/0 0/67 (0%) |
|FIRST INCIDENCE (DAYS) | 507 --- 573 674 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.290N P=0.399N P=0.470N P=0.271N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.220N P=0.408N P=0.311N P=0.215N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.265N P=0.317N P=0.134N P=0.193N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.278N | (e) |
|FISHER EXACT | P=0.348N P=0.139N P=0.191N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 0/16 (0%) 0/88 (0%) 0/99 (0%) | 1/61 (2%) 0/11 (0%) 0/34 (0%) 0/99 (0%) |
|ADJUSTED (b) | 10.0% 0.0% 0.0% 0.0% | 2.5% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/30 (10%) 0/0 0/3 (0%) 0/43 (0%) | 1/40 (3%) 0/1 (0%) 0/0 0/67 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- --- --- | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.045N* (e) P=0.681N P=0.066N | P=0.276N P=0.999N (e) P=0.397N |
|INCIDENTAL TUMOR | P=0.045N* (e) P=0.681N P=0.066N | P=0.276N P=0.999N (e) P=0.397N |
|LOGISTIC REGRESSION | P=0.045N* (e) P=0.681N P=0.066N | P=0.276N P=0.999N (e) P=0.397N |
|COCHRAN-ARMITAGE | P=0.063N | P=0.321N |
|FISHER EXACT | P=0.535N P=0.085N P=0.069N | P=0.847N P=0.642N P=0.381N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/70 (11%) 0/16 (0%) 2/88 (2%) 3/99 (3%) | 1/61 (2%) 0/11 (0%) 0/34 (0%) 0/99 (0%) |
|ADJUSTED (b) | 21.9% 0.0% 1.7% 6.1% | 2.5% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 6/30 (20%) 0/0 0/3 (0%) 2/43 (5%) | 1/40 (3%) 0/1 (0%) 0/0 0/67 (0%) |
|FIRST INCIDENCE (DAYS) | 507 --- 573 674 | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.055N P=0.399N P=0.382N P=0.049N* | P=0.276N P=0.999N (e) P=0.397N |
|INCIDENTAL TUMOR | P=0.036N* P=0.408N P=0.243N P=0.035N* | P=0.276N P=0.999N (e) P=0.397N |
|LOGISTIC REGRESSION | P=0.058N P=0.227N P=0.037N* P=0.032N* | P=0.276N P=0.999N (e) P=0.397N |
|COCHRAN-ARMITAGE | P=0.067N | P=0.321N |
|FISHER EXACT | P=0.178N P=0.021N* P=0.032N* | P=0.847N P=0.642N P=0.381N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/74 (1%) 0/20 (0%) 2/101 (2%) 1/100 (1%) | 0/60 (0%) 0/11 (0%) 0/37 (0%) 0/100 (0%) |
|ADJUSTED (b) | 3.0% 0.0% 2.0% 2.3% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 0/4 (0%) 0/14 (0%) 1/43 (2%) | 0/40 (0%) 0/1 (0%) 0/0 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 626 727 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.616N P=0.897N P=0.465 P=0.702N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.535N P=0.897N P=0.580 P=0.702N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.562N P=0.897N P=0.562 P=0.702N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.579N | (e) |
|FISHER EXACT | P=0.787N P=0.615 P=0.671N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/74 (3%) 0/20 (0%) 2/101 (2%) 1/100 (1%) | 0/60 (0%) 0/11 (0%) 0/37 (0%) 0/100 (0%) |
|ADJUSTED (b) | 6.1% 0.0% 2.0% 2.3% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/33 (6%) 0/4 (0%) 0/14 (0%) 1/43 (2%) | 0/40 (0%) 0/1 (0%) 0/0 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 626 727 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.391N P=0.744N P=0.593 P=0.408N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.324N P=0.744N P=0.692 P=0.408N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.354N P=0.744N P=0.669N P=0.408N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.370N | (e) |
|FISHER EXACT | P=0.618N P=0.565N P=0.388N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 5/50 (10%) 39/149 (26%) 76/100 (76%)| 0/100 (0%) 3/50 (6%) 67/150 (45%) 83/100 (83%)|
|ADJUSTED (b) | 10.2% 13.6% 46.5% 96.1% | 0.0% 7.2% 56.0% 94.3% |
|TERMINAL (d) | 6/59 (10%) 3/34 (9%) 23/63 (37%) 40/43 (93%) | 0/79 (0%) 2/40 (5%) 61/113 (54%) 63/68 (93%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 702 484 515 | --- 719 565 312 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.382 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.035 * P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.333 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.031 * P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.358 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.035 * P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.283 P<0.001 ** P<0.001 ** | P=0.036 * P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 1/50 (2%) 4/149 (3%) 42/100 (42%)| 0/100 (0%) 0/50 (0%) 11/150 (7%) 26/100 (26%)|
|ADJUSTED (b) | 0.0% 2.9% 5.2% 67.4% | 0.0% 0.0% 9.0% 33.1% |
|TERMINAL (d) | 0/59 (0%) 1/34 (3%) 2/63 (3%) 24/43 (56%) | 0/79 (0%) 0/40 (0%) 7/113 (6%) 17/68 (25%) |
|FIRST INCIDENCE (DAYS) | --- 727 (T) 678 575 | --- --- 529 599 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.390 P=0.088 P<0.001 ** | P<0.001 ** (e) P=0.007 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.390 P=0.116 P<0.001 ** | P<0.001 ** (e) P=0.008 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.390 P=0.109 P<0.001 ** | P<0.001 ** (e) P=0.007 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.333 P=0.126 P<0.001 ** | (e) P=0.003 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 6/50 (12%) 42/149 (28%) 82/100 (82%)| 0/100 (0%) 3/50 (6%) 73/150 (49%) 86/100 (86%)|
|ADJUSTED (b) | 10.2% 16.4% 48.9% 98.8% | 0.0% 7.2% 60.0% 95.5% |
|TERMINAL (d) | 6/59 (10%) 4/34 (12%) 24/63 (38%) 42/43 (98%) | 0/79 (0%) 2/40 (5%) 65/113 (58%) 64/68 (94%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 702 484 515 | --- 719 529 312 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.247 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.035 * P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.207 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.031 * P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.225 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.035 * P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.168 P<0.001 ** P<0.001 ** | P=0.036 * P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 6/50 (12%) 42/149 (28%) 82/100 (82%)| 0/100 (0%) 3/50 (6%) 73/150 (49%) 86/100 (86%)|
|ADJUSTED (b) | 10.2% 16.4% 48.9% 98.8% | 0.0% 7.2% 60.0% 95.5% |
|TERMINAL (d) | 6/59 (10%) 4/34 (12%) 24/63 (38%) 42/43 (98%) | 0/79 (0%) 2/40 (5%) 65/113 (58%) 64/68 (94%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 702 484 515 | --- 719 529 312 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.247 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.035 * P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.207 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.031 * P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.225 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.035 * P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.168 P<0.001 ** P<0.001 ** | P=0.036 * P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/71 (3%) 2/17 (12%) 2/91 (2%) 5/99 (5%) | 0/61 (0%) 0/11 (0%) 0/34 (0%) 2/97 (2%) |
|ADJUSTED (b) | 6.7% 100.0% 20.7% 10.6% | 0.0% 0.0% 0.0% 3.1% |
|TERMINAL (d) | 2/30 (7%) 1/1 (100%) 1/5 (20%) 4/42 (10%) | 0/40 (0%) 0/2 (0%) 0/0 2/65 (3%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 676 630 605 | --- --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.520 P=0.031 * P=0.259 P=0.345 | P=0.256 (e) (e) P=0.351 |
|INCIDENTAL TUMOR | P=0.585N P=0.018 * P=0.312 P=0.395 | P=0.256 (e) (e) P=0.351 |
|LOGISTIC REGRESSION | P=0.468 P=0.059 P=0.613 P=0.360 | P=0.256 (e) (e) P=0.351 |
|COCHRAN-ARMITAGE | P=0.398 | P=0.179 |
|FISHER EXACT | P=0.167 P=0.591N P=0.379 | (e) (e) P=0.375 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/71 (0%) 1/17 (6%) 2/91 (2%) 0/99 (0%) | 0/61 (0%) 0/11 (0%) 0/34 (0%) 0/97 (0%) |
|ADJUSTED (b) | 0.0% 2.0% 2.7% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/1 (0%) 0/5 (0%) 0/42 (0%) | 0/40 (0%) 0/2 (0%) 0/0 0/65 (0%) |
|FIRST INCIDENCE (DAYS) | --- 436 695 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.509N P=0.364 P=0.273 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.408N P=0.398 P=0.386 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.351N P=0.286 P=0.165 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.330N | (e) |
|FISHER EXACT | P=0.193 P=0.314 (e) | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/71 (3%) 3/17 (18%) 4/91 (4%) 5/99 (5%) | 0/61 (0%) 0/11 (0%) 0/34 (0%) 2/97 (2%) |
|ADJUSTED (b) | 6.7% 100.0% 22.8% 10.6% | 0.0% 0.0% 0.0% 3.1% |
|TERMINAL (d) | 2/30 (7%) 1/1 (100%) 1/5 (20%) 4/42 (10%) | 0/40 (0%) 0/2 (0%) 0/0 2/65 (3%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 436 630 605 | --- --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.568N P=0.010 ** P=0.086 P=0.345 | P=0.256 (e) (e) P=0.351 |
|INCIDENTAL TUMOR | P=0.457N P=0.008 ** P=0.145 P=0.395 | P=0.256 (e) (e) P=0.351 |
|LOGISTIC REGRESSION | P=0.548N P=0.040 * P=0.218 P=0.360 | P=0.256 (e) (e) P=0.351 |
|COCHRAN-ARMITAGE | P=0.579 | P=0.179 |
|FISHER EXACT | P=0.048 * P=0.464 P=0.379 | (e) (e) P=0.375 |
|=================================================================================================================================|
| |
|Lung |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/71 (0%) 0/17 (0%) 2/91 (2%) 0/99 (0%) | 0/61 (0%) 0/11 (0%) 0/34 (0%) 0/97 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 40.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/1 (0%) 2/5 (40%) 0/42 (0%) | 0/40 (0%) 0/2 (0%) 0/0 0/65 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 727 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.428N (e) P=0.006 ** (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.428N (e) P=0.006 ** (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.428N (e) P=0.006 ** (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.539N | (e) |
|FISHER EXACT | (e) P=0.314 (e) | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 2/50 (4%) 4/150 (3%) 0/100 (0%) | 11/100 (11%) 3/50 (6%) 20/150 (13%) 6/100 (6%) |
|ADJUSTED (b) | 1.7% 5.9% 5.8% 0.0% | 13.5% 7.5% 16.5% 8.2% |
|TERMINAL (d) | 1/59 (2%) 2/34 (6%) 2/63 (3%) 0/43 (0%) | 9/79 (11%) 3/40 (8%) 14/113 (12%) 4/68 (6%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 693 --- | 635 729 (T) 608 682 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.296N P=0.313 P=0.215 P=0.563N | P=0.264N P=0.238N P=0.322 P=0.234N |
|INCIDENTAL TUMOR | P=0.256N P=0.313 P=0.279 P=0.563N | P=0.152N P=0.243N P=0.361 P=0.157N |
|LOGISTIC REGRESSION | P=0.267N P=0.313 P=0.247 P=0.563N | P=0.188N P=0.231N P=0.350 P=0.175N |
|COCHRAN-ARMITAGE | P=0.197N | P=0.166N |
|FISHER EXACT | P=0.258 P=0.335 P=0.500N | P=0.249N P=0.366 P=0.155N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 2/50 (4%) 4/150 (3%) 0/100 (0%) | 11/100 (11%) 3/50 (6%) 21/150 (14%) 7/100 (7%) |
|ADJUSTED (b) | 1.7% 5.9% 5.8% 0.0% | 13.5% 7.5% 17.4% 9.7% |
|TERMINAL (d) | 1/59 (2%) 2/34 (6%) 2/63 (3%) 0/43 (0%) | 9/79 (11%) 3/40 (8%) 15/113 (13%) 5/68 (7%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 693 --- | 635 729 (T) 608 682 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.296N P=0.313 P=0.215 P=0.563N | P=0.361N P=0.238N P=0.271 P=0.328N |
|INCIDENTAL TUMOR | P=0.256N P=0.313 P=0.279 P=0.563N | P=0.228N P=0.243N P=0.305 P=0.238N |
|LOGISTIC REGRESSION | P=0.267N P=0.313 P=0.247 P=0.563N | P=0.270N P=0.231N P=0.295 P=0.257N |
|COCHRAN-ARMITAGE | P=0.197N | P=0.239N |
|FISHER EXACT | P=0.258 P=0.335 P=0.500N | P=0.249N P=0.311 P=0.230N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 2/50 (4%) 4/150 (3%) 0/100 (0%) | 12/100 (12%) 3/50 (6%) 21/150 (14%) 7/100 (7%) |
|ADJUSTED (b) | 1.7% 5.9% 5.8% 0.0% | 14.7% 7.5% 17.4% 9.7% |
|TERMINAL (d) | 1/59 (2%) 2/34 (6%) 2/63 (3%) 0/43 (0%) | 10/79 (13%) 3/40 (8%) 15/113 (13%) 5/68 (7%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 693 --- | 635 729 (T) 608 682 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.296N P=0.313 P=0.215 P=0.563N | P=0.306N P=0.189N P=0.351 P=0.256N |
|INCIDENTAL TUMOR | P=0.256N P=0.313 P=0.279 P=0.563N | P=0.185N P=0.192N P=0.390 P=0.179N |
|LOGISTIC REGRESSION | P=0.267N P=0.313 P=0.247 P=0.563N | P=0.221N P=0.181N P=0.381 P=0.192N |
|COCHRAN-ARMITAGE | P=0.197N | P=0.193N |
|FISHER EXACT | P=0.258 P=0.335 P=0.500N | P=0.196N P=0.398 P=0.167N |
|=================================================================================================================================|
| |
|Nose |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/71 (3%) 0/16 (0%) 0/88 (0%) 0/99 (0%) | 0/61 (0%) 0/11 (0%) 0/35 (0%) 0/98 (0%) |
|ADJUSTED (b) | 2.1% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/30 (0%) 0/0 0/3 (0%) 0/42 (0%) | 0/40 (0%) 0/1 (0%) 0/0 0/66 (0%) |
|FIRST INCIDENCE (DAYS) | 367 --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.206N P=0.399N P=0.161N P=0.242N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.133N P=0.435N P=0.079N P=0.124N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.219N P=0.407N P=0.183N P=0.210N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.147N | (e) |
|FISHER EXACT | P=0.664N P=0.198N P=0.173N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.3% 0.0% | 0.0% 0.0% 1.5% 0.0% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 0/43 (0%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 693 --- | --- --- 429 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.709N (e) P=0.282 (e) | P=0.677N (e) P=0.334 (e) |
|INCIDENTAL TUMOR | P=0.641N (e) P=0.391 (e) | P=0.567N (e) P=0.377 (e) |
|LOGISTIC REGRESSION | P=0.674N (e) P=0.319 (e) | P=0.683N (e) P=0.359 (e) |
|COCHRAN-ARMITAGE | P=0.664N | P=0.664N |
|FISHER EXACT | (e) P=0.359 (e) | (e) P=0.359 (e) |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 1/100 (1%) 1/50 (2%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.3% 0.0% | 1.3% 2.5% 1.5% 0.0% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 0/43 (0%) | 1/79 (1%) 1/40 (3%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 693 --- | 729 (T) 729 (T) 429 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.709N (e) P=0.282 (e) | P=0.300N P=0.602 P=0.634 P=0.530N |
|INCIDENTAL TUMOR | P=0.641N (e) P=0.391 (e) | P=0.240N P=0.602 P=0.673 P=0.530N |
|LOGISTIC REGRESSION | P=0.674N (e) P=0.319 (e) | P=0.271N P=0.602 P=0.667 P=0.530N |
|COCHRAN-ARMITAGE | P=0.664N | P=0.275N |
|FISHER EXACT | (e) P=0.359 (e) | P=0.557 P=0.649 P=0.500N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 1/16 (6%) 5/90 (6%) 0/99 (0%) | 0/61 (0%) 0/11 (0%) 0/34 (0%) 0/100 (0%) |
|ADJUSTED (b) | 3.3% 0.0% 23.1% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/30 (3%) 0/0 1/5 (20%) 0/43 (0%) | 0/40 (0%) 0/1 (0%) 0/0 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 721 510 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.215N P=0.401 P=0.039 * P=0.428N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.152N P=0.310 P=0.071 P=0.428N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.123N P=0.125 P=0.141 P=0.428N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.129N | (e) |
|FISHER EXACT | P=0.339 P=0.175 P=0.414N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/64 (0%) 0/16 (0%) 3/87 (3%) 2/96 (2%) | 2/55 (4%) 0/11 (0%) 0/33 (0%) 0/95 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 34.6% 3.4% | 5.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/23 (0%) 0/0 1/3 (33%) 0/40 (0%) | 2/36 (6%) 0/1 (0%) 0/0 0/63 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 626 679 | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.253 (e) P=0.053 P=0.198 | P=0.085N P=0.976N (e) P=0.127N |
|INCIDENTAL TUMOR | P=0.353 (e) P=0.079 P=0.262 | P=0.085N P=0.976N (e) P=0.127N |
|LOGISTIC REGRESSION | P=0.420 (e) P=0.138 P=0.334 | P=0.085N P=0.976N (e) P=0.127N |
|COCHRAN-ARMITAGE | P=0.388 | P=0.113N |
|FISHER EXACT | (e) P=0.188 P=0.358 | P=0.692N P=0.388N P=0.133N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/77 (26%) 9/22 (41%) 32/96 (33%) 13/97 (13%) | 40/84 (48%) 19/27 (70%) 42/84 (50%) 9/100 (9%) |
|ADJUSTED (b) | 39.3% 100.0% 65.9% 23.4% | 54.1% 84.2% 72.3% 13.2% |
|TERMINAL (d) | 12/37 (32%) 6/6 (100%) 6/11 (55%) 6/43 (14%) | 31/63 (49%) 14/17 (82%) 33/47 (70%) 9/68 (13%) |
|FIRST INCIDENCE (DAYS) | 584 581 546 450 | 523 487 576 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.045N* P=0.139 P=0.004 ** P=0.131N | P<0.001N** P=0.050 * P=0.148 P<0.001N** |
|INCIDENTAL TUMOR | P=0.004N** P=0.040 * P=0.036 * P=0.045N* | P<0.001N** P=0.019 * P=0.189 P<0.001N** |
|LOGISTIC REGRESSION | P=0.002N** P=0.061 P=0.030 * P=0.032N* | P<0.001N** P=0.022 * P=0.224 P<0.001N** |
|COCHRAN-ARMITAGE | P=0.003N** | P<0.001N** |
|FISHER EXACT | P=0.138 P=0.189 P=0.029N* | P=0.032 * P=0.439 P<0.001N** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/77 (0%) 0/22 (0%) 0/96 (0%) 1/97 (1%) | 0/84 (0%) 0/27 (0%) 3/84 (4%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 2.3% | 0.0% 0.0% 5.0% 0.0% |
|TERMINAL (d) | 0/37 (0%) 0/6 (0%) 0/11 (0%) 0/43 (0%) | 0/63 (0%) 0/17 (0%) 2/47 (4%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 726 | --- --- 707 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.193 (e) (e) P=0.441 | P=0.550N (e) P=0.110 (e) |
|INCIDENTAL TUMOR | P=0.236 (e) (e) P=0.515 | P=0.493N (e) P=0.114 (e) |
|LOGISTIC REGRESSION | P=0.345 (e) (e) P=0.534 | P=0.503N (e) P=0.098 (e) |
|COCHRAN-ARMITAGE | P=0.297 | P=0.502N |
|FISHER EXACT | (e) (e) P=0.557 | (e) P=0.123 (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 1/50 (2%) 0/150 (0%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 3.4% 2.9% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/59 (3%) 1/34 (3%) 0/63 (0%) 0/43 (0%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.182N P=0.687N P=0.225N P=0.311N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.182N P=0.687N P=0.225N P=0.311N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.182N P=0.687N P=0.225N P=0.311N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.132N | (e) |
|FISHER EXACT | P=0.742N P=0.159N P=0.249N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 1/150 (1%) 4/100 (4%) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 1/100 (1%) |
|ADJUSTED (b) | 1.7% 0.0% 1.6% 9.3% | 1.3% 0.0% 0.0% 1.5% |
|TERMINAL (d) | 1/59 (2%) 0/34 (0%) 1/63 (2%) 4/43 (9%) | 1/79 (1%) 0/40 (0%) 0/113 (0%) 1/68 (1%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 727 (T) 727 (T) | 729 (T) --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.014 * P=0.610N P=0.747N P=0.099 | P=0.549 P=0.636N P=0.429N P=0.727 |
|INCIDENTAL TUMOR | P=0.014 * P=0.610N P=0.747N P=0.099 | P=0.549 P=0.636N P=0.429N P=0.727 |
|LOGISTIC REGRESSION | P=0.014 * P=0.610N P=0.747N P=0.099 | P=0.549 P=0.636N P=0.429N P=0.727 |
|COCHRAN-ARMITAGE | P=0.034 * | P=0.581 |
|FISHER EXACT | P=0.667N P=0.641N P=0.184 | P=0.667N P=0.400N P=0.751N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 1/150 (1%) 3/100 (3%) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 1/100 (1%) |
|ADJUSTED (b) | 1.7% 0.0% 1.6% 7.0% | 1.3% 0.0% 0.0% 1.5% |
|TERMINAL (d) | 1/59 (2%) 0/34 (0%) 1/63 (2%) 3/43 (7%) | 1/79 (1%) 0/40 (0%) 0/113 (0%) 1/68 (1%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 727 (T) 727 (T) | 729 (T) --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.056 P=0.610N P=0.747N P=0.201 | P=0.549 P=0.636N P=0.429N P=0.727 |
|INCIDENTAL TUMOR | P=0.056 P=0.610N P=0.747N P=0.201 | P=0.549 P=0.636N P=0.429N P=0.727 |
|LOGISTIC REGRESSION | P=0.056 P=0.610N P=0.747N P=0.201 | P=0.549 P=0.636N P=0.429N P=0.727 |
|COCHRAN-ARMITAGE | P=0.103 | P=0.581 |
|FISHER EXACT | P=0.667N P=0.641N P=0.311 | P=0.667N P=0.400N P=0.751N |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.3% 0.0% | 1.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 1/63 (2%) 0/43 (0%) | 1/79 (1%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 529 --- | 729 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.699N (e) P=0.290 (e) | P=0.465N P=0.636N P=0.429N P=0.530N |
|INCIDENTAL TUMOR | P=0.666N (e) P=0.348 (e) | P=0.465N P=0.636N P=0.429N P=0.530N |
|LOGISTIC REGRESSION | P=0.643N (e) P=0.360 (e) | P=0.465N P=0.636N P=0.429N P=0.530N |
|COCHRAN-ARMITAGE | P=0.664N | P=0.443N |
|FISHER EXACT | (e) P=0.359 (e) | P=0.667N P=0.400N P=0.500N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) | 2/100 (2%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 2.3% 0.0% | 2.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 1/63 (2%) 0/43 (0%) | 1/79 (1%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 529 --- | 656 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.699N (e) P=0.290 (e) | P=0.216N P=0.398N P=0.165N P=0.260N |
|INCIDENTAL TUMOR | P=0.666N (e) P=0.348 (e) | P=0.179N P=0.411N P=0.152N P=0.201N |
|LOGISTIC REGRESSION | P=0.643N (e) P=0.360 (e) | P=0.202N P=0.397N P=0.153N P=0.235N |
|COCHRAN-ARMITAGE | P=0.664N | P=0.204N |
|FISHER EXACT | (e) P=0.359 (e) | P=0.443N P=0.159N P=0.249N |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/100 (3%) 1/50 (2%) 3/150 (2%) 4/100 (4%) | 3/100 (3%) 0/50 (0%) 0/150 (0%) 1/100 (1%) |
|ADJUSTED (b) | 5.1% 2.9% 3.9% 9.3% | 3.6% 0.0% 0.0% 1.5% |
|TERMINAL (d) | 3/59 (5%) 1/34 (3%) 2/63 (3%) 4/43 (9%) | 2/79 (3%) 0/40 (0%) 0/113 (0%) 1/68 (1%) |
|FIRST INCIDENCE (DAYS) | 727 (T) 727 (T) 529 727 (T) | 656 --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.205 P=0.516N P=0.606N P=0.332 | P=0.422N P=0.267N P=0.068N P=0.351N |
|INCIDENTAL TUMOR | P=0.217 P=0.516N P=0.566N P=0.332 | P=0.378N P=0.275N P=0.063N P=0.303N |
|LOGISTIC REGRESSION | P=0.280 P=0.516N P=0.492N P=0.332 | P=0.391N P=0.268N P=0.062N P=0.313N |
|COCHRAN-ARMITAGE | P=0.342 | P=0.387N |
|FISHER EXACT | P=0.593N P=0.456N P=0.500 | P=0.293N P=0.063N P=0.311N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 6/50 (12%) 7/150 (5%) 7/100 (7%) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 12.9% 15.9% 7.9% 14.4% | 1.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 7/59 (12%) 3/34 (9%) 1/63 (2%) 4/43 (9%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 651 654 510 684 | 579 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.522 P=0.409 P=0.388N P=0.483 | P=0.447N P=0.638N P=0.425N P=0.506N |
|INCIDENTAL TUMOR | P=0.456N P=0.331 P=0.231N P=0.553 | P=0.388N P=0.638N P=0.362N P=0.419N |
|LOGISTIC REGRESSION | P=0.457N P=0.349 P=0.234N P=0.572 | P=0.452N P=0.574N P=0.393N P=0.473N |
|COCHRAN-ARMITAGE | P=0.381N | P=0.443N |
|FISHER EXACT | P=0.303 P=0.206N P=0.500N | P=0.667N P=0.400N P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 3/50 (6%) 4/150 (3%) 2/100 (2%) | 0/100 (0%) 1/50 (2%) 3/150 (2%) 0/100 (0%) |
|ADJUSTED (b) | 8.3% 7.0% 2.9% 3.4% | 0.0% 2.5% 2.4% 0.0% |
|TERMINAL (d) | 3/59 (5%) 1/34 (3%) 0/63 (0%) 1/43 (2%) | 0/79 (0%) 1/40 (3%) 2/113 (2%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 571 436 455 588 | --- 729 (T) 278 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.141N P=0.599N P=0.229N P=0.207N | P=0.472N P=0.364 P=0.197 (e) |
|INCIDENTAL TUMOR | P=0.041N* P=0.591 P=0.087N P=0.102N | P=0.488N P=0.364 P=0.168 (e) |
|LOGISTIC REGRESSION | P=0.066N P=0.622 P=0.103N P=0.122N | P=0.440N P=0.364 P=0.221 (e) |
|COCHRAN-ARMITAGE | P=0.099N | P=0.438N |
|FISHER EXACT | P=0.653N P=0.161N P=0.140N | P=0.333 P=0.214 (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Lipoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 1/100 (1%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 2/100 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 2.0% | 0.0% 0.0% 0.0% 2.9% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 0/43 (0%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 2/68 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 707 | --- --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.195 (e) (e) P=0.447 | P=0.036 * (e) (e) P=0.207 |
|INCIDENTAL TUMOR | P=0.240 (e) (e) P=0.522 | P=0.036 * (e) (e) P=0.207 |
|LOGISTIC REGRESSION | P=0.214 (e) (e) P=0.478 | P=0.036 * (e) (e) P=0.207 |
|COCHRAN-ARMITAGE | P=0.230 | P=0.047 * |
|FISHER EXACT | (e) (e) P=0.500 | (e) (e) P=0.249 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibroma or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 8/100 (8%) 6/50 (12%) 7/150 (5%) 8/100 (8%) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 12.9% 15.9% 7.9% 16.3% | 1.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 7/59 (12%) 3/34 (9%) 1/63 (2%) 4/43 (9%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 651 654 510 684 | 579 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.390 P=0.409 P=0.388N P=0.368 | P=0.447N P=0.638N P=0.425N P=0.506N |
|INCIDENTAL TUMOR | P=0.558 P=0.331 P=0.231N P=0.452 | P=0.388N P=0.638N P=0.362N P=0.419N |
|LOGISTIC REGRESSION | P=0.547 P=0.349 P=0.234N P=0.451 | P=0.452N P=0.574N P=0.393N P=0.473N |
|COCHRAN-ARMITAGE | P=0.506N | P=0.443N |
|FISHER EXACT | P=0.303 P=0.206N P=0.602N | P=0.667N P=0.400N P=0.500N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 14/100 (14%) 9/50 (18%) 12/150 (8%) 10/100 (10%)| 2/100 (2%) 1/50 (2%) 3/150 (2%) 0/100 (0%) |
|ADJUSTED (b) | 20.7% 22.0% 11.9% 19.4% | 2.0% 2.5% 2.4% 0.0% |
|TERMINAL (d) | 10/59 (17%) 4/34 (12%) 1/63 (2%) 5/43 (12%) | 0/79 (0%) 1/40 (3%) 2/113 (2%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 571 436 455 588 | 334 729 (T) 278 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.388N P=0.453 P=0.243N P=0.501N | P=0.184N P=0.729 P=0.665 P=0.244N |
|INCIDENTAL TUMOR | P=0.146N P=0.329 P=0.068N P=0.331N | P=0.172N P=0.654N P=0.659 P=0.196N |
|LOGISTIC REGRESSION | P=0.165N P=0.335 P=0.073N P=0.316N | P=0.162N P=0.618N P=0.639N P=0.155N |
|COCHRAN-ARMITAGE | P=0.178N | P=0.166N |
|FISHER EXACT | P=0.339 P=0.096N P=0.257N | P=0.742N P=0.665N P=0.249N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/100 (6%) 3/50 (6%) 5/150 (3%) 2/100 (2%) | 1/100 (1%) 1/50 (2%) 3/150 (2%) 0/100 (0%) |
|ADJUSTED (b) | 8.3% 7.0% 4.4% 3.4% | 1.0% 2.5% 2.4% 0.0% |
|TERMINAL (d) | 3/59 (5%) 1/34 (3%) 0/63 (0%) 1/43 (2%) | 0/79 (0%) 1/40 (3%) 2/113 (2%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 571 436 455 588 | 334 729 (T) 278 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.147N P=0.599N P=0.337N P=0.207N | P=0.299N P=0.598 P=0.449 P=0.502N |
|INCIDENTAL TUMOR | P=0.041N* P=0.591 P=0.143N P=0.102N | P=0.313N P=0.687 P=0.321 P=0.500N |
|LOGISTIC REGRESSION | P=0.067N P=0.622 P=0.175N P=0.122N | P=0.279N P=0.743 P=0.519 P=0.417N |
|COCHRAN-ARMITAGE | P=0.100N | P=0.274N |
|FISHER EXACT | P=0.653N P=0.242N P=0.140N | P=0.557 P=0.475 P=0.500N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 1/150 (1%) 3/100 (3%) | 0/100 (0%) 0/50 (0%) 1/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.8% 6.3% | 0.0% 0.0% 0.9% 0.0% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 2/43 (5%) | 0/79 (0%) 0/40 (0%) 1/113 (1%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 597 693 | --- --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.017 * (e) P=0.572 P=0.078 | P=0.793N (e) P=0.571 (e) |
|INCIDENTAL TUMOR | P=0.029 * (e) P=0.674 P=0.093 | P=0.793N (e) P=0.571 (e) |
|LOGISTIC REGRESSION | P=0.026 * (e) P=0.611 P=0.092 | P=0.793N (e) P=0.571 (e) |
|COCHRAN-ARMITAGE | P=0.027 * | P=0.770N |
|FISHER EXACT | (e) P=0.600 P=0.123 | (e) P=0.600 (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 2/150 (1%) 3/100 (3%) | 0/100 (0%) 0/50 (0%) 1/150 (1%) 1/100 (1%) |
|ADJUSTED (b) | 1.7% 0.0% 1.8% 6.3% | 0.0% 0.0% 0.9% 1.2% |
|TERMINAL (d) | 1/59 (2%) 0/34 (0%) 0/63 (0%) 2/43 (5%) | 0/79 (0%) 0/40 (0%) 1/113 (1%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 727 (T) --- 597 693 | --- --- 729 (T) 659 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.092 P=0.610N P=0.577 P=0.211 | P=0.318 (e) P=0.571 P=0.498 |
|INCIDENTAL TUMOR | P=0.134 P=0.610N P=0.677 P=0.236 | P=0.383 (e) P=0.571 P=0.598 |
|LOGISTIC REGRESSION | P=0.127 P=0.610N P=0.652 P=0.239 | P=0.339 (e) P=0.571 P=0.512 |
|COCHRAN-ARMITAGE | P=0.136 | P=0.336 |
|FISHER EXACT | P=0.667N P=0.649 P=0.311 | (e) P=0.600 P=0.500 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 95/99 (96%) 47/50 (94%) 142/150 (95%) 92/100 (92%)| |
|ADJUSTED (b) | 98.9% 100.0% 100.0% 100.0% | |
|TERMINAL (d) | 58/59 (98%) 34/34 (100%) 63/63 (100%) 43/43 (100%)| |
|FIRST INCIDENCE (DAYS) | 503 520 455 461 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.010 * P=0.148N P=0.006 ** P=0.026 * | |
|INCIDENTAL TUMOR | P=0.322N P=0.429N P=0.593 P=0.331N | |
|LOGISTIC REGRESSION | P=0.255N P=0.431N P=0.575N P=0.287N | |
|COCHRAN-ARMITAGE | P=0.167N | |
|FISHER EXACT | P=0.435N P=0.443N P=0.191N | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/72 (29%) 4/17 (24%) 20/89 (22%) 20/98 (20%) | 16/62 (26%) 4/15 (27%) 5/37 (14%) 10/96 (10%) |
|ADJUSTED (b) | 43.6% 9.0% 38.6% 33.4% | 32.4% 25.5% 51.5% 13.7% |
|TERMINAL (d) | 12/33 (36%) 0/1 (0%) 1/4 (25%) 9/42 (21%) | 12/41 (29%) 1/5 (20%) 1/2 (50%) 7/67 (10%) |
|FIRST INCIDENCE (DAYS) | 651 520 531 462 | 606 706 588 614 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.480N P=0.414N P=0.191 P=0.446N | P=0.015N* P=0.576 P=0.534N P=0.023N* |
|INCIDENTAL TUMOR | P=0.146N P=0.600N P=0.532N P=0.177N | P=0.005N** P=0.539 P=0.426N P=0.009N** |
|LOGISTIC REGRESSION | P=0.122N P=0.591N P=0.497N P=0.136N | P=0.004N** P=0.493 P=0.258N P=0.008N** |
|COCHRAN-ARMITAGE | P=0.147N | P=0.008N** |
|FISHER EXACT | P=0.446N P=0.215N P=0.128N | P=0.590 P=0.115N P=0.011N* |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/72 (4%) 1/17 (6%) 3/89 (3%) 2/98 (2%) | 1/62 (2%) 2/15 (13%) 1/37 (3%) 1/96 (1%) |
|ADJUSTED (b) | 7.2% 100.0% 3.0% 4.8% | 1.1% 40.0% 50.0% 1.5% |
|TERMINAL (d) | 2/33 (6%) 1/1 (100%) 0/4 (0%) 2/42 (5%) | 0/41 (0%) 2/5 (40%) 1/2 (50%) 1/67 (1%) |
|FIRST INCIDENCE (DAYS) | 632 727 (T) 517 727 (T) | 652 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.283N P=0.447 P=0.494 P=0.422N | P=0.194N P=0.070 P=0.601 P=0.713N |
|INCIDENTAL TUMOR | P=0.214N P=0.377 P=0.679 P=0.345N | P=0.180N P=0.064 P=0.614 P=0.669N |
|LOGISTIC REGRESSION | P=0.246N P=0.552 P=0.583N P=0.380N | P=0.193N P=0.069 P=0.597 P=0.663N |
|COCHRAN-ARMITAGE | P=0.260N | P=0.227N |
|FISHER EXACT | P=0.579 P=0.554N P=0.357N | P=0.095 P=0.610 P=0.632N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/72 (32%) 5/17 (29%) 23/89 (26%) 21/98 (21%) | 17/62 (27%) 6/15 (40%) 6/37 (16%) 11/96 (11%) |
|ADJUSTED (b) | 46.9% 100.0% 40.4% 35.5% | 33.2% 62.8% 100.0% 15.2% |
|TERMINAL (d) | 13/33 (39%) 1/1 (100%) 1/4 (25%) 10/42 (24%) | 12/41 (29%) 3/5 (60%) 2/2 (100%) 8/67 (12%) |
|FIRST INCIDENCE (DAYS) | 632 520 517 462 | 606 706 588 614 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.363N P=0.547N P=0.150 P=0.371N | P=0.006N** P=0.246 P=0.620N P=0.024N* |
|INCIDENTAL TUMOR | P=0.075N P=0.482 P=0.552N P=0.116N | P=0.002N** P=0.188 P=0.524N P=0.009N** |
|LOGISTIC REGRESSION | P=0.064N P=0.533 P=0.509N P=0.092N | P=0.002N** P=0.160 P=0.331N P=0.008N** |
|COCHRAN-ARMITAGE | P=0.080N | P=0.003N** |
|FISHER EXACT | P=0.544N P=0.249N P=0.086N | P=0.256 P=0.151N P=0.010N** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 27
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/72 (1%) 0/17 (0%) 4/89 (4%) 0/98 (0%) | 0/62 (0%) 0/15 (0%) 0/37 (0%) 0/96 (0%) |
|ADJUSTED (b) | 1.6% 0.0% 27.5% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/33 (0%) 0/1 (0%) 1/4 (25%) 0/42 (0%) | 0/41 (0%) 0/5 (0%) 0/2 (0%) 0/67 (0%) |
|FIRST INCIDENCE (DAYS) | 710 --- 626 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.370N P=0.609N P=0.127 P=0.562N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.246N P=0.682N P=0.243 P=0.470N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.219N P=0.866N P=0.138 P=0.447N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.231N | (e) |
|FISHER EXACT | P=0.809N P=0.257 P=0.424N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/72 (3%) 0/17 (0%) 1/89 (1%) 0/98 (0%) | 0/62 (0%) 0/15 (0%) 0/37 (0%) 0/96 (0%) |
|ADJUSTED (b) | 4.1% 0.0% 25.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 0/1 (0%) 1/4 (25%) 0/42 (0%) | 0/41 (0%) 0/5 (0%) 0/2 (0%) 0/67 (0%) |
|FIRST INCIDENCE (DAYS) | 577 --- 727 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.152N P=0.604N P=0.678 P=0.216N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.119N P=0.682N P=0.762 P=0.135N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.148N P=0.557N P=0.480N P=0.172N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.150N | (e) |
|FISHER EXACT | P=0.653N P=0.421N P=0.178N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 28
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/72 (4%) 0/17 (0%) 5/89 (6%) 0/98 (0%) | 0/62 (0%) 0/15 (0%) 0/37 (0%) 0/96 (0%) |
|ADJUSTED (b) | 5.6% 0.0% 51.6% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/33 (3%) 0/1 (0%) 2/4 (50%) 0/42 (0%) | 0/41 (0%) 0/5 (0%) 0/2 (0%) 0/67 (0%) |
|FIRST INCIDENCE (DAYS) | 577 --- 626 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.112N P=0.368N P=0.129 P=0.128N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.056N P=0.460N P=0.260 P=0.063N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.062N P=0.457N P=0.330 P=0.073N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.065N | (e) |
|FISHER EXACT | P=0.525N P=0.483 P=0.074N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 1/150 (1%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 1.2% 0.0% | 0.0% 0.0% 1.5% 0.0% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 0/43 (0%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 693 --- | --- --- 429 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.798N (e) P=0.538 (e) | P=0.677N (e) P=0.334 (e) |
|INCIDENTAL TUMOR | P=0.760N (e) P=0.630 (e) | P=0.567N (e) P=0.377 (e) |
|LOGISTIC REGRESSION | P=0.777N (e) P=0.572 (e) | P=0.683N (e) P=0.359 (e) |
|COCHRAN-ARMITAGE | P=0.770N | P=0.664N |
|FISHER EXACT | (e) P=0.600 (e) | (e) P=0.359 (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 29
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 1/150 (1%) 0/100 (0%) | 1/100 (1%) 1/50 (2%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 1.2% 0.0% | 1.3% 2.5% 1.5% 0.0% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 0/43 (0%) | 1/79 (1%) 1/40 (3%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 693 --- | 729 (T) 729 (T) 429 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.798N (e) P=0.538 (e) | P=0.300N P=0.602 P=0.634 P=0.530N |
|INCIDENTAL TUMOR | P=0.760N (e) P=0.630 (e) | P=0.240N P=0.602 P=0.673 P=0.530N |
|LOGISTIC REGRESSION | P=0.777N (e) P=0.572 (e) | P=0.271N P=0.602 P=0.667 P=0.530N |
|COCHRAN-ARMITAGE | P=0.770N | P=0.275N |
|FISHER EXACT | (e) P=0.600 (e) | P=0.557 P=0.649 P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 3/100 (3%) 2/50 (4%) 0/150 (0%) 1/100 (1%) |
|ADJUSTED (b) | | 3.6% 4.7% 0.0% 1.5% |
|TERMINAL (d) | | 2/79 (3%) 1/40 (3%) 0/113 (0%) 1/68 (1%) |
|FIRST INCIDENCE (DAYS) | | 606 684 --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.223N P=0.574 P=0.067N P=0.351N |
|INCIDENTAL TUMOR | | P=0.180N P=0.559 P=0.055N P=0.311N |
|LOGISTIC REGRESSION | | P=0.194N P=0.568 P=0.060N P=0.304N |
|COCHRAN-ARMITAGE | | P=0.194N |
|FISHER EXACT | | P=0.541 P=0.063N P=0.311N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 30
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 11/100 (11%) 2/50 (4%) 13/150 (9%) 11/100 (11%)|
|ADJUSTED (b) | | 13.9% 5.0% 11.3% 16.2% |
|TERMINAL (d) | | 11/79 (14%) 2/40 (5%) 12/113 (11%) 11/68 (16%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) 729 (T) 646 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.216 P=0.123N P=0.391N P=0.441 |
|INCIDENTAL TUMOR | | P=0.230 P=0.123N P=0.386N P=0.441 |
|LOGISTIC REGRESSION | | P=0.260 P=0.123N P=0.360N P=0.441 |
|COCHRAN-ARMITAGE | | P=0.347 |
|FISHER EXACT | | P=0.127N P=0.343N P=0.589N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 11/100 (11%) 2/50 (4%) 14/150 (9%) 12/100 (12%)|
|ADJUSTED (b) | | 13.9% 5.0% 12.2% 17.2% |
|TERMINAL (d) | | 11/79 (14%) 2/40 (5%) 13/113 (12%) 11/68 (16%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) 729 (T) 646 674 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.151 P=0.123N P=0.463N P=0.354 |
|INCIDENTAL TUMOR | | P=0.172 P=0.123N P=0.458N P=0.376 |
|LOGISTIC REGRESSION | | P=0.196 P=0.123N P=0.430N P=0.414 |
|COCHRAN-ARMITAGE | | P=0.263 |
|FISHER EXACT | | P=0.127N P=0.411N P=0.500 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 31
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 0/100 (0%) | 0/100 (0%) 0/50 (0%) 2/150 (1%) 0/100 (0%) |
|ADJUSTED (b) | 1.2% 0.0% 0.0% 0.0% | 0.0% 0.0% 1.6% 0.0% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 0/43 (0%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 651 --- --- --- | --- --- 610 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.466N P=0.633N P=0.443N P=0.531N | P=0.683N (e) P=0.329 (e) |
|INCIDENTAL TUMOR | P=0.422N P=0.690N P=0.370N P=0.478N | P=0.561N (e) P=0.377 (e) |
|LOGISTIC REGRESSION | P=0.432N P=0.646N P=0.403N P=0.484N | P=0.660N (e) P=0.340 (e) |
|COCHRAN-ARMITAGE | P=0.443N | P=0.664N |
|FISHER EXACT | P=0.667N P=0.400N P=0.500N | (e) P=0.359 (e) |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/100 (0%) 0/50 (0%) 1/150 (1%) 2/100 (2%) | 0/100 (0%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.9% 4.4% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 1/43 (2%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 639 718 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073 (e) P=0.560 P=0.180 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.123 (e) P=0.674 P=0.216 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.092 (e) P=0.602 P=0.188 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.099 | (e) |
|FISHER EXACT | (e) P=0.600 P=0.249 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 32
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 57/100 (57%) 32/50 (64%) 111/150 (74%) 68/100 (68%)| 27/100 (27%) 20/50 (40%) 66/150 (44%) 48/100 (48%)|
|ADJUSTED (b) | 68.4% 71.0% 84.5% 77.5% | 31.4% 43.4% 48.7% 51.5% |
|TERMINAL (d) | 33/59 (56%) 21/34 (62%) 44/63 (70%) 25/43 (58%) | 21/79 (27%) 14/40 (35%) 45/113 (40%) 24/68 (35%) |
|FIRST INCIDENCE (DAYS) | 505 520 397 461 | 515 592 485 491 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** P=0.544N P<0.001 ** P=0.006 ** | P=0.002 ** P=0.102 P=0.005 ** P=0.001 ** |
|INCIDENTAL TUMOR | P=0.178 P=0.228 P=0.005 ** P=0.101 | P=0.017 * P=0.070 P=0.006 ** P=0.005 ** |
|LOGISTIC REGRESSION | P=0.181 P=0.296 P=0.003 ** P=0.094 | P=0.014 * P=0.076 P=0.004 ** P=0.003 ** |
|COCHRAN-ARMITAGE | P=0.129 | P=0.006 ** |
|FISHER EXACT | P=0.260 P=0.004 ** P=0.072 | P=0.077 P=0.005 ** P=0.002 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/50 (0%) 1/150 (1%) 0/100 (0%) | 0/100 (0%) 1/50 (2%) 0/150 (0%) 1/100 (1%) |
|ADJUSTED (b) | 2.1% 0.0% 1.4% 0.0% | 0.0% 2.5% 0.0% 1.5% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 0/43 (0%) | 0/79 (0%) 1/40 (3%) 0/113 (0%) 1/68 (1%) |
|FIRST INCIDENCE (DAYS) | 503 --- 710 --- | --- 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.248N P=0.402N P=0.404N P=0.244N | P=0.473 P=0.364 (e) P=0.470 |
|INCIDENTAL TUMOR | P=0.152N P=0.435N P=0.231N P=0.124N | P=0.473 P=0.364 (e) P=0.470 |
|LOGISTIC REGRESSION | P=0.199N P=0.416N P=0.310N P=0.209N | P=0.473 P=0.364 (e) P=0.470 |
|COCHRAN-ARMITAGE | P=0.223N | P=0.506 |
|FISHER EXACT | P=0.443N P=0.351N P=0.249N | P=0.333 (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 33
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/100 (2%) 0/50 (0%) 1/150 (1%) 0/100 (0%) | 0/100 (0%) 1/50 (2%) 0/150 (0%) 1/100 (1%) |
|ADJUSTED (b) | 2.1% 0.0% 1.4% 0.0% | 0.0% 2.5% 0.0% 1.5% |
|TERMINAL (d) | 0/59 (0%) 0/34 (0%) 0/63 (0%) 0/43 (0%) | 0/79 (0%) 1/40 (3%) 0/113 (0%) 1/68 (1%) |
|FIRST INCIDENCE (DAYS) | 503 --- 710 --- | --- 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.248N P=0.402N P=0.404N P=0.244N | P=0.473 P=0.364 (e) P=0.470 |
|INCIDENTAL TUMOR | P=0.152N P=0.435N P=0.231N P=0.124N | P=0.473 P=0.364 (e) P=0.470 |
|LOGISTIC REGRESSION | P=0.199N P=0.416N P=0.310N P=0.209N | P=0.473 P=0.364 (e) P=0.470 |
|COCHRAN-ARMITAGE | P=0.223N | P=0.506 |
|FISHER EXACT | P=0.443N P=0.351N P=0.249N | P=0.333 (e) P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 7/100 (7%) 0/50 (0%) 6/150 (4%) 1/100 (1%) | 1/100 (1%) 0/50 (0%) 0/150 (0%) 0/100 (0%) |
|ADJUSTED (b) | 9.8% 0.0% 6.5% 1.2% | 1.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 4/59 (7%) 0/34 (0%) 0/63 (0%) 0/43 (0%) | 0/79 (0%) 0/40 (0%) 0/113 (0%) 0/68 (0%) |
|FIRST INCIDENCE (DAYS) | 503 --- 594 604 | 681 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.115N P=0.058N P=0.361N P=0.064N | P=0.450N P=0.627N P=0.421N P=0.507N |
|INCIDENTAL TUMOR | P=0.040N* P=0.052N P=0.154N P=0.028N* | P=0.367N P=0.657N P=0.402N P=0.402N |
|LOGISTIC REGRESSION | P=0.056N P=0.069N P=0.199N P=0.027N* | P=0.440N P=0.632N P=0.415N P=0.493N |
|COCHRAN-ARMITAGE | P=0.066N | P=0.443N |
|FISHER EXACT | P=0.054N P=0.223N P=0.032N* | P=0.667N P=0.400N P=0.500N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 34
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 97/100 (97%) 48/50 (96%) 145/150 (97%) 98/100 (98%)| 64/100 (64%) 25/50 (50%) 108/150 (72%) 87/100 (87%)|
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 70.1% 54.2% 81.1% 97.7% |
|TERMINAL (d) | 59/59 (100%) 34/34 (100%) 63/63 (100%) 43/43 (100%)| 52/79 (66%) 19/40 (48%) 88/113 (78%) 66/68 (97%) |
|FIRST INCIDENCE (DAYS) | 503 520 455 450 | 523 487 565 312 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003 ** P=0.146N P=0.006 ** P=0.009 ** | P<0.001 ** P=0.084N P=0.071 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.197 P=0.557N P=0.456 P=0.336 | P<0.001 ** P=0.080N P=0.092 P<0.001 ** |
|LOGISTIC REGRESSION | P=0.255 P=0.597N P=0.577 P=0.427 | P<0.001 ** P=0.071N P=0.089 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.364 | P<0.001 ** |
|FISHER EXACT | P=0.541N P=0.595N P=0.500 | P=0.071N P=0.116 P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 77/100 (77%) 39/50 (78%) 125/150 (83%) 89/100 (89%)| 36/100 (36%) 25/50 (50%) 79/150 (53%) 63/100 (63%)|
|ADJUSTED (b) | 80.9% 79.6% 88.4% 92.6% | 39.6% 53.2% 55.5% 66.0% |
|TERMINAL (d) | 41/59 (69%) 24/34 (71%) 47/63 (75%) 36/43 (84%) | 25/79 (32%) 18/40 (45%) 51/113 (45%) 36/68 (53%) |
|FIRST INCIDENCE (DAYS) | 367 436 397 461 | 334 592 278 312 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.307N P=0.006 ** P=0.002 ** | P<0.001 ** P=0.110 P=0.010 * P<0.001 ** |
|INCIDENTAL TUMOR | P=0.041 * P=0.433 P=0.290 P=0.052 | P=0.001 ** P=0.069 P=0.009 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.036 * P=0.494 P=0.187 P=0.046 * | P<0.001 ** P=0.071 P=0.007 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.013 * | P<0.001 ** |
|FISHER EXACT | P=0.532 P=0.140 P=0.019 * | P=0.071 P=0.007 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05077 TEST: 01 PAGE 35
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- FIREMASTER FF-1 POLYBROMINATED BIPHEN
MALE TERMINAL SACRIFICE AT 104 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 3 PPM 10 PPM 30 PPM | 0 PPM 3 PPM 10 PPM 30 PPM |
| | 10-0 1-1 10-3 10-10 | 10-0 1-1 10-3 10-10 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) |100/100 (100% 50/50 (100%)150/150 (100%100/100 (100%) 77/100 (77%) 35/50 (70%) 132/150 (88%) 97/100 (97%)|
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 78.5% 71.4% 88.6% 99.0% |
|TERMINAL (d) | 59/59 (100%) 34/34 (100%) 63/63 (100%) 43/43 (100%)| 58/79 (73%) 26/40 (65%) 96/113 (85%) 67/68 (99%) |
|FIRST INCIDENCE (DAYS) | 367 436 397 450 | 334 487 278 312 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** P=0.179N P=0.006 ** P=0.013 * | P<0.001 ** P=0.259N P=0.037 * P<0.001 ** |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P<0.001 ** P=0.251N P=0.021 * P<0.001 ** |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P<0.001 ** P=0.232N P=0.018 * P<0.001 ** |
|COCHRAN-ARMITAGE | (e) | P<0.001 ** |
|FISHER EXACT | P=1.000N P=1.000N P=1.000N | P=0.231N P=0.017 * P<0.001 ** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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