TDMS Study 05077-01 Pathology Tables
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 Facility: Battelle Columbus Laboratory Chemical CAS #: 67774-32-7 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| | 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 2 1 1 2 2 2 2 3 2 2 2 2 2 3 2 1 3 2 2 2 2 X X| Clear Cell Focus | X X | Eosinophilic Focus | 1 1 | Hematopoietic Cell Proliferation | 3 | Hepatodiaphragmatic Nodule | | Inflammation, Chronic Active | 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 | Necrosis | 1 1 | Vacuolization Cytoplasmic | 4 4 | Bile Duct, Hyperplasia | 1 2 | __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + I + +| Acinus, Atrophy | 1 1 2 2 1 1 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Chronic | 2 2 2 2 2 2 2 2 2 1 2 3 2 2 1 2 2 2 2 3 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 2 3 2 2 2 2 3 2 2 2 2 2 2 2 2| Hypertrophy | 2 2 2 2 2 3 | Vacuolization Cytoplasmic | 2 2 2 2 2 1 1 3 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| | 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hyperplasia | 2 2 2 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + I + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M M + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X X X X X X X X X X | Pars Distalis, Hyperplasia | 3 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 2 2 3 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 1 2 | Duct, Dilatation | 3 3 3 3 3 3 3 3 3 3 3| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Lymphocyte | 3 | Follicle, Cyst | X | Periovarian Tissue, Cyst | X X X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 3 2 3| Cervix, Cyst | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hyperplasia | 3 | Mediastinal, Infiltration Cellular, | | Histiocyte | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + | Hyperplasia, Lymphoid | 4 | Infiltration Cellular, Histiocyte | 3 | Sinus, Ectasia | 4 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thymus | + + + + + + + + + + + + M M + + + + + + + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 3 3 2 2 3 3 3 2 3 3 3 3 2 3 2 3 2 3 3 3 2 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3| | 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X X X X X | Necrosis | 3 | __________________________________________________________________________| Spinal Cord | + + | Nerve, Demyelination | 2 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | Lens, Cataract | 3 2 3 | Retina, Atrophy | 4 4 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 4 2 1 1 1 2 2 2 3| Renal Tubule, Mineralization | 2 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| | | 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2| 47 2.0| Clear Cell Focus | 2 | 3 2.0| Eosinophilic Focus | 3| 3 1.7| Hematopoietic Cell Proliferation | | 1 3.0| Hepatodiaphragmatic Nodule | X | 1 | Inflammation, Chronic Active | 1 2 2 3 1 2 2 2 2 2 2 2 2 2 2 1 | 34 1.9| Necrosis | 1 | 3 1.0| Vacuolization Cytoplasmic | 2 | 3 3.3| Bile Duct, Hyperplasia | 2 1 2 1 2 2 2 2 1 3 1 3| 14 1.8| __________________________________________________________________________|____________| Mesentery | + | 2 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | 2 2 1 2 2 1 2 3 | 15 1.7| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Chronic | 2 2 2 2 3 2 3 2 2 3 2 2 3 3 2 2 2 3 2 2 1 | 42 2.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| | | 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 39 2.1| Hypertrophy | 2 2 2 2 2 2 2 2 2| 15 2.1| Vacuolization Cytoplasmic | 2 2 2 2 2 3 2 1 | 17 1.9| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 2 2 | 6 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M + M + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | X X X X X X X X X X| 20 | Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 3 2 2| 13 2.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 3 2 3 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3| 50 2.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 2 2 2 2 2 2 2 2 2 3 2 3| 24 2.1| Duct, Dilatation | 3 3 3 3 3 3 3 3| 19 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Lymphocyte | 3 3 | 3 3.0| Follicle, Cyst | X X | 3 | Periovarian Tissue, Cyst | X X | 9 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 3 4 2 | 7 3.0| Cervix, Cyst | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Hyperplasia | | 1 3.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + | 4 | Hyperplasia, Lymphoid | | 1 4.0| Infiltration Cellular, Histiocyte | | 1 3.0| Sinus, Ectasia | 4 | 2 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| | | 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Thymus | M M + + + + + + + + + M + + + + + + + + + + + + +| 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia, Cystic | 2 2 3 3 3 2 3 3 2 3 2 3 3 2 3 2 3 2 3 3 2 3 2| 46 2.6| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X | 7 | Necrosis | | 1 3.0| __________________________________________________________________________|____________| Spinal Cord | | 2 | Nerve, Demyelination | | 2 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 4 | Lens, Cataract | 3 | 4 2.8| Retina, Atrophy | 4 | 4 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Nephropathy, Chronic | 2 1 2 1 2 2 1 2 1 1 2 1 1 1 4 1| 25 1.7| Renal Tubule, Mineralization | | 3 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| | 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + | __________________________________________________________________________| Intestine Large | + + + + | __________________________________________________________________________| Intestine Large, Cecum | M + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + | __________________________________________________________________________| Intestine Large, Rectum | + + + + | __________________________________________________________________________| Intestine Small | + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | 2 2 X 2 1 3 2 2 2 2 2 3 1 2 2 1 1 2 2 2 2 2 2| Degeneration, Cystic | 1 | Eosinophilic Focus | 1 1 1 2 X 3 1 1 1 1 1 1 2 2| Hepatodiaphragmatic Nodule | X | Inflammation, Chronic Active | 2 1 2 | Vacuolization Cytoplasmic | 2 1 3 | Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 2 2 1 1 | __________________________________________________________________________| Mesentery | | Inflammation, Chronic Active | | __________________________________________________________________________| Pancreas | + + + + + | Acinus, Atrophy | 2 | __________________________________________________________________________| Salivary Glands | + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Inflammation, Chronic Active | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + | Degeneration, Chronic | 2 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + | Hyperplasia | 2 2 | Hypertrophy | | Vacuolization Cytoplasmic | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + | __________________________________________________________________________| Islets, Pancreatic | + + + + + | __________________________________________________________________________| Parathyroid Gland | + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| | 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + | C-Cell, Hyperplasia | 3 3 2 3 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + | Hyperplasia | 2 | Inflammation, Chronic Active | 3 2 2 3 2 2 4 | __________________________________________________________________________| Ovary | + + + + + + + + + + | Follicle, Cyst | | Periovarian Tissue, Cyst | X X X X X X | __________________________________________________________________________| Uterus | + + + + + + | Endometrium, Hyperplasia, Cystic, | | Glandular | 2 4 3 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + | __________________________________________________________________________| Lymph Node | M + + + | __________________________________________________________________________| Lymph Node, Mesenteric | | Cyst | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thymus | + + M + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + M + | Hyperplasia, Cystic | 2 3 2 | __________________________________________________________________________| Skin | + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + | Compression | | Hydrocephalus | | __________________________________________________________________________| Spinal Cord | + | Nerve, Demyelination | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3| | 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + | __________________________________________________________________________| Trachea | + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Choroid, Hemorrhage | | Lens, Cataract | 4 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + | Hydronephrosis | | Nephropathy, Chronic | 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + | Mucosa, Hyperplasia, Papillary | | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + | 11 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + | 11 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + | 11 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + | 11 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Basophilic Focus | 1 2 2 2 1 1 2 2 2 1 1 3 2 2 1 1 2 2 1 2 2| 44 1.8| Degeneration, Cystic | 1 | 2 1.0| Eosinophilic Focus | 2 2 2 1 1| 19 1.4| Hepatodiaphragmatic Nodule | X X| 3 | Inflammation, Chronic Active | 1 1 2 1 2 2 2 1 1 | 12 1.5| Vacuolization Cytoplasmic | 3 4 3 | 6 2.7| Bile Duct, Hyperplasia | 2 2 1 1 3 1 2 | 18 1.7| __________________________________________________________________________|____________| Mesentery | + | 1 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + | 12 | Acinus, Atrophy | 2 | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + | 11 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 1 2 | 2 1.5| Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + | 11 | Degeneration, Chronic | 2 | 3 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + | 11 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + | 10 | Hyperplasia | 2 2 2 2 | 6 2.0| Hypertrophy | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Vacuolization Cytoplasmic | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + | 12 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + M + | 9 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| 34 | Pars Distalis, Cyst | X X X X X X X| 9 | Pars Distalis, Hyperplasia | 2 2 3 3 3| 7 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + | 12 | C-Cell, Hyperplasia | 2 1 3 3 2 2 | 11 2.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + | 15 | Hyperplasia | | 1 2.0| Inflammation, Chronic Active | 2 2 2 4 2 2 | 13 2.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + | 23 | Follicle, Cyst | X | 1 | Periovarian Tissue, Cyst | X X X X X | 11 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + +| 17 | Endometrium, Hyperplasia, Cystic, | | | Glandular | | 4 2.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + | 11 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 11 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + | 2 | Cyst | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Thymus | + + + + M + + | 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + | 16 | Hyperplasia, Cystic | 3 3 2 3 3 3 3 | 10 2.7| __________________________________________________________________________|____________| Skin | + + + + + + + | 11 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | | 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + | 11 | Compression | X X X | 3 | Hydrocephalus | 3 3 2 | 3 2.7| __________________________________________________________________________|____________| Spinal Cord | + | 2 | Nerve, Demyelination | 2 | 2 1.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + | 11 | __________________________________________________________________________|____________| Nose | + + + + + + + | 11 | __________________________________________________________________________|____________| Trachea | + + + + + + + | 11 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | Choroid, Hemorrhage | 3 | 1 3.0| Lens, Cataract | 3 | 2 3.5| Retina, Atrophy | 4 | 2 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + | 11 | Hydronephrosis | 3 | 1 3.0| Nephropathy, Chronic | 2 2 2 1 2 | 7 1.7| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + | 11 | Mucosa, Hyperplasia, Papillary | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7| DAY ON TEST | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3| | 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + | Diverticulum | 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + | __________________________________________________________________________| Intestine Small | + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + M + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X 2 2 3 2 2 2 3 2 2 2 2 2 1 2 1 2 X 2 2| Cytomegaly | 1 | Eosinophilic Focus | X 1 1 3 X X X 2 3 1 1 1 X 1| Hepatodiaphragmatic Nodule | X | Hyperplasia, Focal | | Hypertrophy | 2 3 1 2 2 1| Inflammation, Chronic Active | 2 3 2 2 3 2 2 2 1 | Necrosis | 2 | Vacuolization Cytoplasmic | 1 1 2 1 3 2 4 3 4 1 2| Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 4 3 3 1 2| __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Pancreas | + + + + + + + | Acinus, Atrophy | 2 | __________________________________________________________________________| Salivary Glands | + + + + + M + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Mineralization | 3 2 | Ulcer | 2 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + | Degeneration, Chronic | 2 3 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + | Hyperplasia | 2 | Hypertrophy | 2 2 | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7| DAY ON TEST | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3| | 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Necrosis | 3 | Vacuolization Cytoplasmic | 2 2 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + | Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + | __________________________________________________________________________| Parathyroid Gland | + + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + +| Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia | 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + +| C-Cell, Hyperplasia | 3 3 3 3 3 3 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + | Hyperplasia | 3 | Inflammation, Chronic Active | 2 2 2 2 2 2 | Duct, Dilatation | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + | Periovarian Tissue, Cyst | X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + | Dilatation | 4 | Fibrosis | | Cervix, Cyst | X X | Endometrium, Hyperplasia, Cystic, | | Glandular | 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + | __________________________________________________________________________| Lymph Node | + + + + + + M + | __________________________________________________________________________| Lymph Node, Mesenteric | + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 | Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Thymus | + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + + | Hyperplasia, Cystic | 3 3 3 3 3 4 | __________________________________________________________________________| Skin | + + + + + + + | Subcutaneous Tissue, Lip, Foreign | | Body | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7| DAY ON TEST | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3| | 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Lip, | | Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + | Cranium, Fracture | X | Femur, Hyperostosis | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + | Compression | X X | Hemorrhage | | Hydrocephalus | 2 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + | __________________________________________________________________________| Nose | + + + + + + + | __________________________________________________________________________| Trachea | + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Lens, Cataract | | Retina, Atrophy | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + | Nephropathy, Chronic | 2 2 2 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8| | | 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + +| 11 | __________________________________________________________________________|____________| Intestine Large | + + + +| 12 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + +| 11 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + +| 12 | Diverticulum | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + +| 11 | __________________________________________________________________________|____________| Intestine Small | + + + +| 11 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + +| 11 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + +| 10 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + +| 11 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 2 2 2 2 1 2 X 2 2 2 2 2 2 2 2 2 2 1 2 2 | 40 1.9| Cytomegaly | | 1 1.0| Eosinophilic Focus | 1 1 3 3 1 | 19 1.6| Hepatodiaphragmatic Nodule | X | 2 | Hyperplasia, Focal | 1 | 1 1.0| Hypertrophy | 1 1 2 | 9 1.7| Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 1 | 19 2.0| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | 2 2 2 2 4 3 4 | 18 2.4| Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 2 4 2 2 2 4 2 2 2 2 2 | 34 2.2| __________________________________________________________________________|____________| Mesentery | | 1 | Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + +| 11 | Acinus, Atrophy | 1 2 | 3 1.7| __________________________________________________________________________|____________| Salivary Glands | + + + +| 10 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 2.0| Mineralization | 3 2 2 | 5 2.4| Ulcer | | 1 2.0| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + +| 12 | Degeneration, Chronic | 2 | 4 2.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8| | | 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + +| 12 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + +| 12 | Hyperplasia | 2 | 2 2.0| Hypertrophy | 2 | 3 2.0| Necrosis | 3 | 2 3.0| Vacuolization Cytoplasmic | | 3 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + +| 12 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + +| 11 | __________________________________________________________________________|____________| Parathyroid Gland | + + + +| 11 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + +| 27 | Pars Distalis, Cyst | | 1 | Pars Distalis, Hyperplasia | 2 3 3 2 3 | 6 2.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + +| 15 | C-Cell, Hyperplasia | 3 2 3 3 2| 12 2.8| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + +| 12 | Hyperplasia | | 1 3.0| Inflammation, Chronic Active | 2 2 2 2| 10 2.0| Duct, Dilatation | 3 3 2 | 3 2.7| __________________________________________________________________________|____________| Ovary | + + + + + + +| 19 | Periovarian Tissue, Cyst | X X X X | 8 | __________________________________________________________________________|____________| Uterus | + + + + + + + +| 18 | Dilatation | | 1 4.0| Fibrosis | 3 | 1 3.0| Cervix, Cyst | | 2 | Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 3 | 4 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + +| 11 | __________________________________________________________________________|____________| Lymph Node | + + + +| 11 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| | DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8| | | 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Depletion Lymphoid | | 1 2.0| Hematopoietic Cell Proliferation | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + +| 11 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + +| 13 | Hyperplasia, Cystic | 3 3 3 2| 10 3.0| __________________________________________________________________________|____________| Skin | + + + + +| 12 | Subcutaneous Tissue, Lip, Foreign | | | Body | 4| 1 4.0| Subcutaneous Tissue, Lip, | | | Inflammation, Chronic Active | 4| 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + +| 11 | Cranium, Fracture | | 1 | Femur, Hyperostosis | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + +| 11 | Compression | X | 3 | Hemorrhage | 1 | 1 1.0| Hydrocephalus | 3 | 3 2.7| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + +| 11 | __________________________________________________________________________|____________| Nose | + + + +| 11 | __________________________________________________________________________|____________| Trachea | + + + +| 11 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | Lens, Cataract | 3 | 1 3.0| Retina, Atrophy | 4 | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + +| 11 | Nephropathy, Chronic | 3 2 2 | 8 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + +| 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| | 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + A + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + | __________________________________________________________________________| Intestine Large, Colon | + + + + + A + | __________________________________________________________________________| Intestine Large, Rectum | + + + + + A + | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small | + + + + + A + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | 2 3 2 2 2 2 2 3 2 2 2 2 3 2 2 2 2| Eosinophilic Focus | 3 2 2 2 2 4 3 2 3 3 4 2 3 4 4 4 4 3 1 3 3 3 2| Hypertrophy | 1 1 1 2 1 2 2 2 1 1 2 2 2 2 2 2 | Inflammation, Chronic, Multifocal | 1 1 2 2 2 2 2 2| Inflammation, Chronic Active | 2 2 2 2 2 2 2 3 | Necrosis | 1 | Vacuolization Cytoplasmic | 4 3 2 3 2 2 3 3 2 3 2 3 4 4 2 2 3 3 2 3 4 2 3 2 | Bile Duct, Hyperplasia | 4 2 2 2 2 3 2 2 3 3 2 2 2 2 3 2| Oval Cell, Hyperplasia | 3 1 1 2 2 2 | Subserosa, Congestion, Multifocal | 2 | __________________________________________________________________________| Mesentery | | Inflammation, Chronic Active | | __________________________________________________________________________| Pancreas | + + + + + M + | Ectopic Liver | X | Acinus, Atrophy | 3 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 3 | Inflammation, Chronic Active | | Ulcer | 2 | Submucosa, Foreign Body | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Mineralization | 2 | Ulcer | | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + | Degeneration, Chronic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| | 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Gland | + + + + + A + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + A + + | Hyperplasia | 2 | Hypertrophy | | Necrosis | 2 | Vacuolization Cytoplasmic | 3 4 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + A + + | __________________________________________________________________________| Islets, Pancreatic | + + + + + M + | __________________________________________________________________________| Parathyroid Gland | + + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + +| Hyperplasia | | Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + A + + | C-Cell, Hyperplasia | 2 3 2 2 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + | Hyperplasia | 2 | Inflammation, Chronic Active | 2 | Duct, Dilatation | 2 2 3 | __________________________________________________________________________| Ovary | + + + + + + + + + +| Periovarian Tissue, Cyst | X X X| __________________________________________________________________________| Uterus | + + + + + + + + + | Dilatation | 3 | Endometrium, Hyperplasia, Cystic, | | Glandular | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + A + | __________________________________________________________________________| Lymph Node | + + + + + + + | __________________________________________________________________________| Lymph Node, Mesenteric | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Thymus | + + + I M + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 3 3 3 2 3 | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3| | 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + A + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + | Compression | X X | Hydrocephalus | 2 3 | __________________________________________________________________________| Spinal Cord | + | Nerve, Demyelination | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + | Interstitium, Inflammation, Chronic | | Active | 2 | __________________________________________________________________________| Nose | + + + + + A + | Mucosa, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Trachea | + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Lens, Cataract | 4 | Retina, Atrophy | 4 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + | Nephropathy, Chronic | 2 2 3 2 1 2 | Cortex, Infarct | | Renal Tubule, Mineralization | 2 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3| | | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + | 14 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + | 13 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + | 13 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + | 13 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + | 13 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + | 13 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + | 13 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + | 13 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + M + | 12 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 4 2 | 4 2.3| Basophilic Focus | 4 3 2 2 X 2 3 2 2 2 1 2 2 2 2 2 2 3 2 2| 37 2.2| Eosinophilic Focus | 4 3 4 2 2 3 2 3 2 3 1 2 4 X 3 3 1 3 4 2 3 3 2 4| 47 2.8| Hypertrophy | 2 3 1 2 1 2 2 1 2 1 2 1 1 1 1 1| 32 1.6| Inflammation, Chronic, Multifocal | 2 1 2 2 2 2 1 2 2 2 2 1 2| 21 1.8| Inflammation, Chronic Active | 2 1 2 2 2 | 13 2.0| Necrosis | 2 2 2 1 | 5 1.6| Vacuolization Cytoplasmic | 4 3 2 3 3 4 2 2 3 2 2 3 3 3 3 3 2 4 2 3 3 2 2| 47 2.7| Bile Duct, Hyperplasia | 3 2 2 2 3 2 2 2 2 2 2 3 3 3 2 2 3 2 2 3 2 2 2| 39 2.3| Oval Cell, Hyperplasia | 2 2 2 2 1 1| 12 1.8| Subserosa, Congestion, Multifocal | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + | 1 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + | 13 | Ectopic Liver | | 1 | Acinus, Atrophy | 2 2 | 4 2.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + | 14 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 | 3 2.7| Inflammation, Chronic Active | 2 | 1 2.0| Ulcer | | 1 2.0| Submucosa, Foreign Body | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 | 1 2.0| Mineralization | 2 2 | 3 2.0| Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3| | | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + | 14 | Degeneration, Chronic | 2 2 2 | 3 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + | 14 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + | 14 | Hyperplasia | 3 2 | 3 2.3| Hypertrophy | 2 | 1 2.0| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | 2 2 3 2 | 6 2.7| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + | 13 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + | 13 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + | 14 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + | 29 | Hyperplasia | 2 | 1 2.0| Pars Distalis, Cyst | X X X | 5 | Pars Distalis, Hyperplasia | 3 3 | 3 2.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + | 14 | C-Cell, Hyperplasia | 3 3 3 3 3 2 | 12 2.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + | 16 | Hyperplasia | | 1 2.0| Inflammation, Chronic Active | 3 2 2 2 2 | 6 2.2| Duct, Dilatation | 3 3 3 2 2 | 8 2.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + +| 22 | Periovarian Tissue, Cyst | X X X X X X | 9 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + | 18 | Dilatation | | 1 3.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + | 13 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3| | | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + | 14 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 | 1 3.0| Hematopoietic Cell Proliferation | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + M + + + + | 11 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + M + + + + + +| 21 | Hyperplasia, Cystic | 3 3 2 3 2 3 | 13 2.6| __________________________________________________________________________|____________| Skin | + + + + + + + | 13 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + | 14 | Compression | X | 3 | Hydrocephalus | 3 | 3 2.7| __________________________________________________________________________|____________| Spinal Cord | | 1 | Nerve, Demyelination | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + | 14 | Interstitium, Inflammation, Chronic | | | Active | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + | 13 | Mucosa, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 4 | Lens, Cataract | 3 3 3 | 4 3.3| Retina, Atrophy | 4 4 4 | 4 4.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + | 14 | Nephropathy, Chronic | 1 2 1 3 1 | 11 1.8| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| | DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3| | | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Cortex, Infarct | 3 | 1 3.0| Renal Tubule, Mineralization | | 2 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| DAY ON TEST | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3| | 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + | Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + A + + + A + + | __________________________________________________________________________| Intestine Small | + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + | __________________________________________________________________________| Intestine Small, Ileum | + A + + + A + + | __________________________________________________________________________| Intestine Small, Jejunum | + A + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Basophilic Focus | 2 2 3 2 2 2 2 1 2 3 1 2 2 1 2 2 1 3| Degeneration, Cystic | 4 2 | Eosinophilic Focus | 4 3 4 3 3 4 2 3 2 2 2 2 4 3 2 2 3 3 4 2 4| Eosinophilic Focus, Multiple | X | Hypertrophy | 1 2 2 2 2 1 1 1 1 1 2 2 2 1 1 1 1 1| Inflammation, Chronic, Multifocal | 1 1 1 1| Inflammation, Chronic Active | 2 4 2 2 | Necrosis | 2 | Vacuolization Cytoplasmic | 3 4 3 2 3 3 2 3 3 4 2 3 2 2 2 3 4 3 3| Bile Duct, Cyst | | Bile Duct, Hyperplasia | 2 2 2 3 2 2 2 3 2 2 3 1 2 2 2 2 2 2| Oval Cell, Hyperplasia | 1 3 2 3 1 2 1 | Periportal, Infiltration Cellular, | | Lymphocyte | 4 1 | __________________________________________________________________________| Mesentery | | Inflammation, Chronic Active | | __________________________________________________________________________| Pancreas | + A + + + A + + | Acinus, Atrophy | 2 2 4 | __________________________________________________________________________| Salivary Glands | + + + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 2 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + | Degeneration, Chronic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + A + + + A + + | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| DAY ON TEST | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3| | 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + A + + + A + + | Cyst | X | Hyperplasia | 2 | Necrosis | | Vacuolization Cytoplasmic | 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + A + + + A + + | __________________________________________________________________________| Islets, Pancreatic | + A + + + A + + | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + | Pars Distalis, Cyst | X X X | Pars Distalis, Hyperplasia | 3 2 | __________________________________________________________________________| Thyroid Gland | + A + + + + + + | Atrophy | | Infiltration Cellular, Lymphocyte | 2 | C-Cell, Hyperplasia | 3 2 2 2 2 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + A + + + + + + | Inflammation, Chronic Active | 2 2 | Duct, Dilatation | 3 2 3 | __________________________________________________________________________| Ovary | + + + + + + + + + | Periovarian Tissue, Cyst | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + +| Hemorrhage | | Inflammation, Acute | | Necrosis | | Endometrium, Hyperplasia, Cystic, | | Glandular | 4 2 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + A + + + A + + | __________________________________________________________________________| Lymph Node | + + + + + + + + | __________________________________________________________________________| Lymph Node, Mesenteric | | Angiectasis | | __________________________________________________________________________| Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 | Fibrosis | 2 | Hematopoietic Cell Proliferation | 3 | Capsule, Hemorrhage | 3 | __________________________________________________________________________| Thymus | + M + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| DAY ON TEST | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3| | 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + M + + + + + + | Hyperplasia, Cystic | 3 3 3 3 3 2 3 | __________________________________________________________________________| Skin | + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + | Femur, Hyperostosis | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + A + + + + + + | Compression | X X | Hydrocephalus | 2 2 | __________________________________________________________________________| Spinal Cord | | Nerve, Demyelination | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + | __________________________________________________________________________| Nose | + A + + + + + + | __________________________________________________________________________| Trachea | + A + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Lens, Cataract | | Retina, Atrophy | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + | Nephropathy, Chronic | 2 1 2 1 2 | __________________________________________________________________________| Urinary Bladder | + A + + + + + + | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + +| 11 | __________________________________________________________________________|____________| Intestine Large | + + +| 11 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + +| 10 | __________________________________________________________________________|____________| Intestine Large, Colon | + + +| 11 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + +| 9 | __________________________________________________________________________|____________| Intestine Small | + + +| 11 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + +| 10 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + +| 9 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + +| 10 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 1 1.0| Basophilic Focus | 2 1 2 2 2 2 2 3 2 2 2 2 2 4 2 2 X 2 | 36 2.0| Degeneration, Cystic | | 2 3.0| Eosinophilic Focus | 4 2 2 4 4 2 3 3 3 X 2 3 3 4 3 3 4 4 4 4 3 3 3 3| 45 3.0| Eosinophilic Focus, Multiple | | 1 | Hypertrophy | 3 2 1 3 3 2 1 1 1 1 1 1 2 2 1 1 1 1 2 2 2| 39 1.5| Inflammation, Chronic, Multifocal | 1 1 1 1 | 8 1.0| Inflammation, Chronic Active | 2 2 2 2 2 1 2 2 | 12 2.1| Necrosis | 1 1 1 1 | 5 1.2| Vacuolization Cytoplasmic | 4 2 3 2 2 3 2 2 2 3 2 3 3 3 2 3 3 3 2 3 2 3 2 4| 43 2.7| Bile Duct, Cyst | X | 1 | Bile Duct, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2| 38 2.0| Oval Cell, Hyperplasia | 3 1 1 2 3 2 2 1 2 1 1 2| 19 1.8| Periportal, Infiltration Cellular, | | | Lymphocyte | | 2 2.5| __________________________________________________________________________|____________| Mesentery | + | 1 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + +| 9 | Acinus, Atrophy | 2 | 4 2.5| __________________________________________________________________________|____________| Salivary Glands | + + +| 11 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 3 | 2 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 2 2 2 | 6 2.0| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + +| 11 | Degeneration, Chronic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + +| 9 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + +| 9 | Cyst | | 1 | Hyperplasia | | 1 2.0| Necrosis | 3 | 1 3.0| Vacuolization Cytoplasmic | | 1 1.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + +| 9 | __________________________________________________________________________|____________| Islets, Pancreatic | + + +| 9 | __________________________________________________________________________|____________| Parathyroid Gland | + M +| 9 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + +| 28 | Pars Distalis, Cyst | X X X X X| 8 | Pars Distalis, Hyperplasia | 3 3 3 3 | 6 2.8| __________________________________________________________________________|____________| Thyroid Gland | + + +| 10 | Atrophy | 3| 1 3.0| Infiltration Cellular, Lymphocyte | | 1 2.0| C-Cell, Hyperplasia | 3 3 3| 10 2.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + +| 10 | Inflammation, Chronic Active | 2 | 3 2.0| Duct, Dilatation | | 3 2.7| __________________________________________________________________________|____________| Ovary | + + + + +| 14 | Periovarian Tissue, Cyst | X X | 3 | __________________________________________________________________________|____________| Uterus | + + + + + + + + +| 21 | Hemorrhage | 3 4| 2 3.5| Inflammation, Acute | 4| 1 4.0| Necrosis | 4| 1 4.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 2 2 2 | 7 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + +| 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + +| 12 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 1 | Angiectasis | 4 | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Depletion Lymphoid | | 1 2.0| Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | | 1 3.0| Capsule, Hemorrhage | | 1 3.0| __________________________________________________________________________|____________| Thymus | M + +| 9 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + +| 16 | Hyperplasia, Cystic | 3 3 3| 10 2.9| __________________________________________________________________________|____________| Skin | + + +| 11 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + +| 11 | Femur, Hyperostosis | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + +| 10 | Compression | X | 3 | Hydrocephalus | 3 | 3 2.3| __________________________________________________________________________|____________| Spinal Cord | + | 1 | Nerve, Demyelination | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + | 9 | __________________________________________________________________________|____________| Nose | + + +| 10 | __________________________________________________________________________|____________| Trachea | + + +| 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 3 | Lens, Cataract | 3 4 4 | 3 3.7| Retina, Atrophy | 4 4 4 | 3 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + +| 11 | Nephropathy, Chronic | 1 2 1| 8 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + +| 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| | 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + +| __________________________________________________________________________| Intestine Large | + M + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + +| Necrosis | 2 | __________________________________________________________________________| Intestine Large, Colon | + M + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + +| __________________________________________________________________________| Intestine Small | + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 2 2 2 1 3 2 3 2 3 2 X | Degeneration, Cystic | 2 | Eosinophilic Focus | 4 4 4 2 2 4 4 4 3 3 4 4 4 4 2 4 4 4 4 4 4 2| Hematopoietic Cell Proliferation | | Hepatodiaphragmatic Nodule | X | Hypertrophy | 2 1 2 1 1 3 1 1 1 2 2 2 1 1 2 2 2 1 1 1 2| Inflammation, Chronic, Multifocal | 1 2 1 | Inflammation, Chronic Active | 2 2 2 2 2 | Necrosis | 3 2 3 1 | Vacuolization Cytoplasmic | 3 3 3 2 2 2 2 2 2 3 3 3 3 2 2 3 2 2 2 2 2 3 2 4| Bile Duct, Cyst | | Bile Duct, Hyperplasia | 2 2 3 2 2 3 2 2 2 1 2 2 3 2 3 1 2 2 2 2 2 2 2 2| Oval Cell, Hyperplasia | 2 1 2 2 1 2 2 2 2 2 1 2 2 2 2 2 | __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Pancreas | + + + + +| Acinus, Atrophy | 2 | __________________________________________________________________________| Salivary Glands | + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 3 2 1 3 2 2 2 | Ulcer | | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + +| Degeneration, Chronic | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + +| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| | 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + +| Hyperplasia | | Hypertrophy, Focal | | Necrosis | 4 | Vacuolization Cytoplasmic | 3 2| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + +| Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 2 3 | __________________________________________________________________________| Thyroid Gland | + + + + + +| C-Cell, Hyperplasia | 3 2 2 3 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + +| Hyperplasia | 2 | Inflammation, Chronic Active | 2 2| Duct, Dilatation | 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + +| Follicle, Cyst | X| Periovarian Tissue, Cyst | X X X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + +| Cervix, Cyst | X | Endometrium, Hyperplasia, Cystic, | | Glandular | 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + +| __________________________________________________________________________| Lymph Node | + + + + +| Mandibular, Necrosis | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Necrosis | 4 | __________________________________________________________________________| Thymus | + + + I +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + +| Hyperplasia, Cystic | 3 2 3| __________________________________________________________________________| Skin | + + + + +| _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| | 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + +| Femur, Hyperostosis | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + +| Compression | | Hydrocephalus | | __________________________________________________________________________| Spinal Cord | | Nerve, Demyelination | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + +| Interstitium, Inflammation, Chronic | | Active | 3 | __________________________________________________________________________| Nose | + + + + +| __________________________________________________________________________| Trachea | + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + | Lens, Cataract | 3 4 3 | Retina, Atrophy | 4 4 4 | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + +| Nephropathy, Chronic | 1 1 2 | __________________________________________________________________________| Urinary Bladder | + + + + +| Calculus Micro Observation Only | | Mucosa, Hyperplasia, Papillary | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7| | DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3| | | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + | 12 | Necrosis | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + M | 11 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + | 12 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 2 2 2 1 2 2 2 2 2 1 2 3 | 23 2.0| Degeneration, Cystic | 2 3 | 3 2.3| Eosinophilic Focus | 4 2 4 4 4 4 4 4 3 3 4 3 3 4 2 4 4 3 4 3 4 3 4| 45 3.5| Hematopoietic Cell Proliferation | 2 | 1 2.0| Hepatodiaphragmatic Nodule | | 1 | Hypertrophy | 3 2 2 2 2 3 3 2 2 2 2 1 2 2 3 2 1 1 1 | 40 1.8| Inflammation, Chronic, Multifocal | 2 2 1 1 | 7 1.4| Inflammation, Chronic Active | 2 2 2 | 8 2.0| Necrosis | 2 | 5 2.2| Vacuolization Cytoplasmic | 3 3 2 3 2 3 2 3 3 4 2 2 2 2 3 2 3 3 3 | 43 2.5| Bile Duct, Cyst | 2 | 1 2.0| Bile Duct, Hyperplasia | 3 2 2 2 2 3 2 2 2 2 3 2 3 2 3 2 2 1 3 2| 44 2.2| Oval Cell, Hyperplasia | 2 1 3 2 2 1 1 1 2 1 2 3 3 2 1 1 2 2| 34 1.8| __________________________________________________________________________|____________| Mesentery | + + + | 4 | Inflammation, Chronic Active | 2 3 | 3 2.7| __________________________________________________________________________|____________| Pancreas | + + + + + + + | 12 | Acinus, Atrophy | 2 3 | 3 2.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + | 12 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 3 | 1 3.0| Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 1 | 10 2.0| Ulcer | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7| | DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3| | | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + | 12 | Degeneration, Chronic | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + | 12 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + | 12 | Hyperplasia | 2 3 | 2 2.5| Hypertrophy, Focal | 4 | 1 4.0| Necrosis | | 1 4.0| Vacuolization Cytoplasmic | 2 2 2 1 | 6 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + | 12 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + | 12 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + | 10 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + | 27 | Pars Distalis, Cyst | X | 3 | Pars Distalis, Hyperplasia | 3 2 3 2 2 2 | 8 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + | 13 | C-Cell, Hyperplasia | 3 2 3 2 3 2 3 | 12 2.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + +| 13 | Hyperplasia | | 1 2.0| Inflammation, Chronic Active | 2 3 2 | 5 2.2| Duct, Dilatation | 2 2 3| 4 2.5| __________________________________________________________________________|____________| Ovary | + + + + + + + + | 20 | Follicle, Cyst | | 1 | Periovarian Tissue, Cyst | X | 8 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + | 20 | Cervix, Cyst | X X | 3 | Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 3 2 2 | 6 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | I + + + + + + | 11 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + | 12 | Mandibular, Necrosis | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7| | DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3| | | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 2 3 | 2 2.5| Necrosis | | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + + M + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + | 11 | Hyperplasia, Cystic | 3 2 3 3 2 3 | 9 2.7| __________________________________________________________________________|____________| Skin | + + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + | 12 | Femur, Hyperostosis | X | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + | 12 | Compression | X | 1 | Hydrocephalus | 3 | 1 3.0| __________________________________________________________________________|____________| Spinal Cord | + | 1 | Nerve, Demyelination | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + | 11 | Interstitium, Inflammation, Chronic | | | Active | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + | 12 | __________________________________________________________________________|____________| Trachea | + + + + + + + | 12 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 5 | Lens, Cataract | 3 3 | 5 3.2| Retina, Atrophy | 4 4 | 5 4.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + | 12 | Nephropathy, Chronic | 1 1 2 2 2 | 8 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + M | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7| | DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3| | | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Calculus Micro Observation Only | X | 1 | Mucosa, Hyperplasia, Papillary | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| | 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 1 2 2 2 2 2 2 3 2 | Eosinophilic Focus | 4 4 4 4 2 4 4 4 4 4 4 2 4 4 4 4 3 4 4 4 4 4 4 | Hypertrophy | 3 3 2 2 3 2 3 3 3 3| Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | Inflammation, Chronic Active | 2 2 | Necrosis | 3 | Vacuolization Cytoplasmic | 3 2 3 2 2 2 2 2 3 3 2 3 4 3 2 1 3 3 3 3 3 3 3 3 4| Bile Duct, Cyst | 2 | Bile Duct, Fibrosis | 2 | Bile Duct, Hyperplasia | 3 2 3 2 2 2 2 3 2 2 3 2 2 2 3 2 3 2 3 3 2 3 3 2 2| Bile Duct, Metaplasia | 1 | Oval Cell, Hyperplasia | 2 2 3 1 2 3 2 2 2 3 3 3 3 3 4 3 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 2 1 3 4 2 2 2 3 2 2 3 2 3 4 2 2 | Perivascular, Inflammation, Chronic | | Active | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Cytomegaly, Focal | 2 | Acinus, Atrophy | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Chronic | 1 2 2 2 2 2 2 2 2 2 2 2 1 | Myocardium, Inflammation, Chronic | | Active | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| | 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 3 2 2 3 2 4 3 2 3 3 | Hypertrophy | 2 2 2 3 2 2 2 2| Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 3 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + M + + + + M M + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia | 3 2 2 3 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| C-Cell, Hyperplasia | 2 2 2 2 3 2 2 3 3 2 3 3 2 2 3 2 3 2 2 2 2 2 | Follicle, Cyst | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 | Duct, Dilatation | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Follicle, Cyst | | Periovarian Tissue, Cyst | X X X| Rete Ovarii, Hyperplasia | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic, | | Glandular | 2 3 2 3 3 3 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Angiectasis | 3 | Mediastinal, Angiectasis | | __________________________________________________________________________| Lymph Node, Mesenteric | | Angiectasis | | __________________________________________________________________________| Lymph Node, Thoracic | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + M + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| DAY ON TEST | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| | 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 2 3 3 3 2 3 3 2 3 3 2 3 3 2 3 3 4 3 2 3 2 3| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Subcutaneous Tissue, Inflammation, | | Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Femur, Hyperostosis | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Focal, Granulomatous | | Alveolar Epithelium, Hyperplasia | | Interstitium, Inflammation, Chronic | | Active | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Inflammation, Chronic Active | 2 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Lens, Cataract | 3 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 2 2 1 2 1 2 2 2 1 2 1 1 2 1 1 1 1 2 2 1 2 | Renal Tubule, Mineralization | 2 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7| | | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + + + + + + M + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + M + + A + + + + + + + + + + + + + + + + +| 47 | Parasite Metazoan | X X | 6 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 2 3 | 11 2.1| Eosinophilic Focus | 4 2 4 4 4 4 4 4 4 4 4 4 4 4 1 4 4 4 2 3 4 3 4 3 4| 48 3.7| Hypertrophy | 4 2 3 3 4 2 3 | 17 2.8| Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 | 31 2.0| Inflammation, Chronic Active | 2 | 3 2.0| Necrosis | | 1 3.0| Vacuolization Cytoplasmic | 3 3 2 2 3 3 2 2 3 3 4 2 3 2 2 2 2 3 3 2 3 3 3 2 3| 50 2.6| Bile Duct, Cyst | 3 | 2 2.5| Bile Duct, Fibrosis | 2 2 | 3 2.0| Bile Duct, Hyperplasia | 2 2 2 2 3 3 3 3 3 2 3 2 2 2 2 2 3 3 2 2 3 3 2 2 2| 51 2.4| Bile Duct, Metaplasia | | 1 1.0| Oval Cell, Hyperplasia | 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3 3 4 3 3 3| 42 2.9| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 3 2 1 1 2 4 4 2 2 2 2 2 | 29 2.3| Perivascular, Inflammation, Chronic | | | Active | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cytomegaly, Focal | | 1 2.0| Acinus, Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 | Inflammation, Chronic Active | 2 | 1 2.0| Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Chronic | 2 2 1 3 2 2 2 2 | 21 1.9| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7| | | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Myocardium, Inflammation, Chronic | | | Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 3 2 | 19 2.4| Hypertrophy | 2 | 9 2.1| Vacuolization Cytoplasmic | 2 3 1 2 2 2 3 2 3 | 18 2.2| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 46 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | | 1 | Pars Distalis, Hyperplasia | 3 3 2 3 2 2 2 | 13 2.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | C-Cell, Hyperplasia | 2 2 3 2 2 2 2 3 2 2 3 2 2 2 2 2 2 3 2 2 2| 43 2.3| Follicle, Cyst | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + M + + + + + + + M + + + + + +| 47 | Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 3 | 22 2.0| Duct, Dilatation | 3 3 3 3 3 3 3 3 3 3 3 | 26 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Follicle, Cyst | X | 1 | Periovarian Tissue, Cyst | X X X X X X X X| 11 | Rete Ovarii, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Endometrium, Hyperplasia, Cystic, | | | Glandular | 3 2 3 2 3 | 12 2.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7| | | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Mandibular, Angiectasis | | 1 3.0| Mediastinal, Angiectasis | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 5 | Angiectasis | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Thoracic | + + | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + M + I + M + M + + + + + + M + + + + + + + + +| 41 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Hyperplasia, Cystic | 3 2 3 3 3 2 3 3 3 3 3 3 3 3 2 3 3 3 2 3 4 3 2| 47 2.7| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 3 | 1 3.0| Subcutaneous Tissue, Inflammation, | | | Chronic Active | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Femur, Hyperostosis | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + M + + + + + + + + + + + + + + +| 47 | Inflammation, Focal, Granulomatous | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 3 1 | 2 2.0| Interstitium, Inflammation, Chronic | | | Active | | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Mucosa, Inflammation, Chronic Active | 2 2 | 4 2.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Lens, Cataract | | 1 3.0| Retina, Atrophy | | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7| | | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy, Chronic | 2 1 2 1 2 1 3 2 2 1 1 1 2 2 2 1| 37 1.6| Renal Tubule, Mineralization | | 2 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| DAY ON TEST | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| | 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 3 4 2 3 X 3 2 2 | Cytomegaly | | Eosinophilic Focus | 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 4 4| Hypertrophy | 2 3 2 | Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 | Inflammation, Chronic Active | 2 | Inflammation, Multifocal | | Necrosis | 2 | Thrombosis | X | Vacuolization Cytoplasmic | 2 3 4 4 3 3 2 2 2 2 2 3 2 3 3 3 3 2 2 2| Bile Duct, Cyst | X X | Bile Duct, Fibrosis | 2 2 3 2 2 2 3 3 | Bile Duct, Hyperplasia | 3 2 2 2 2 3 4 | Oval Cell, Hyperplasia | 3 3 4 4 3 3 3 3 3 4 3 3 3 4 3 3 3 3 3 3 3 3 3 3| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Focal Cellular Change, Multiple | | Acinus, Atrophy | 2 3 3 1 3 1 3 3 2 3 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 2 | Inflammation, Chronic Active | 2 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia, Focal | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Chronic | 1 2 2 2 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| DAY ON TEST | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| | 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 2 2 2 2 2 3 2 3 2 2 3| Hypertrophy | 2 2 1 3 | Vacuolization Cytoplasmic | 2 2 2 2 2 3 3 2 2 2 2 3 2| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 3 2 3 2 3 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 3 3 3 3 2 2 2 2 3 2 3 2 3| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Inflammation, Chronic Active | 2 2 2 2 2 2 2 | Duct, Dilatation | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| Periovarian Tissue, Cyst | X X X X X| __________________________________________________________________________| Oviduct | | Dilatation | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Cervix, Cyst | X | Cervix, Mucosa, Hyperplasia, Squamous| 2| Endometrium, Hyperplasia, Cystic, | | Glandular | 2 3 3 3| __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + I + + + + + I + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + M + + + + + +| Mandibular, Infiltration Cellular, | | Plasma Cell | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thymus | + + + + + M + + M + + + + + + M + + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| DAY ON TEST | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3| | 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 2 3 2 3 2 2 2 3 3 3 1 3 2 2 2 3 3 3 3 3| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Focal, Osseous | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Inflammation, Chronic Active | 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Lens, Cataract | 3 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 1 1 2 2 2 1 1 1 1 2 2 1 1 1 1 2 2 1 1 1| Renal Tubule, Inflammation, Acute, | | Multifocal | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | DAY ON TEST | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3| | | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 3 3 2 2 2 | 13 2.6| Cytomegaly | 3 | 1 3.0| Eosinophilic Focus | 4 4 4 4 4 4 4 3 2 4 4 4 4 3 4 4 3 4 4 4 4 4 4| 47 3.8| Hypertrophy | 3 2 3 | 6 2.5| Inflammation, Chronic, Multifocal | 2 2 2 2 2 1 2 2 2 2| 22 2.0| Inflammation, Chronic Active | 2 | 2 2.0| Inflammation, Multifocal | 2 | 1 2.0| Necrosis | 3 2 | 3 2.3| Thrombosis | | 1 | Vacuolization Cytoplasmic | 2 3 2 3 2 4 3 3 3 2 2 4 2 3 3 4 3 3 2 3 | 40 2.7| Bile Duct, Cyst | X X X | 5 | Bile Duct, Fibrosis | 3 3 3 3 2 3 2 3 4 3 3 | 19 2.7| Bile Duct, Hyperplasia | 2 3 3 2 2 2 2 2 | 15 2.4| Oval Cell, Hyperplasia | 3 3 4 3 3 3 3 3 1 3 3 3 3 3 2 3 4 4 3 3| 44 3.1| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Focal Cellular Change, Multiple | 2 | 1 2.0| Acinus, Atrophy | 2 1 4 2 3 3 3 3 1 2 4 2 3 2 | 25 2.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 | Acinus, Atrophy | 2 | 2 2.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 2 2 | 5 2.0| Inflammation, Chronic Active | 3 2 | 3 2.3| Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dysplasia, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | DAY ON TEST | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3| | | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Chronic | 2 2 2 2 2 2 | 11 1.9| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X | 2 | Hyperplasia | 2 2 3 3 2 3 3 2 2 3| 21 2.4| Hypertrophy | 2 2 3 2 2| 9 2.1| Vacuolization Cytoplasmic | 2 3 2 2 2 3 1 2 3 2 2 2 | 25 2.2| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | X | 1 | Pars Distalis, Hyperplasia | 3 2 2 2 2 | 13 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | C-Cell, Hyperplasia | 2 2 3 2 2 2 2 2 3 2 2 2 3 2 3 3 3 3 3 2 3 3 2 2| 47 2.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + + + + + + + M + + + + + + + + + M + + +| 46 | Inflammation, Chronic Active | 2 2 2 2 2 4 | 13 2.2| Duct, Dilatation | 3 3 3 3 3 3 3 3 3 | 23 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Periovarian Tissue, Cyst | X X X X | 9 | __________________________________________________________________________|____________| Oviduct | + | 1 | Dilatation | 3 | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 3 | 1 3.0| Cervix, Cyst | X | 2 | Cervix, Mucosa, Hyperplasia, Squamous| | 1 2.0| Endometrium, Hyperplasia, Cystic, | | | Glandular | 2 2 2 2 2 2 3 | 11 2.4| __________________________________________________________________________|____________| Vagina | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | DAY ON TEST | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3| | | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 1 | __________________________________________________________________________|____________| Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 | Mandibular, Infiltration Cellular, | | | Plasma Cell | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Thymus | + M M + + M + + M + + + + + + + + + + + + + + + +| 42 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + M + + + + + + + + M + + + + +| 48 | Hyperplasia, Cystic | 2 3 3 2 2 2 3 2 3 3 3 3 3 2 3 4 3 2 2 2 2| 43 2.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Focal, Osseous | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mucosa, Inflammation, Chronic Active | 2| 2 2.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 5 | Lens, Cataract | 3 3 3 | 4 3.0| Retina, Atrophy | 4 4 4 | 4 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy, Chronic | 2 2 2 2 1 2 3 1 2 2 2 2 2 1 2 1 1 1 1 1 2 1 | 42 1.5| Renal Tubule, Inflammation, Acute, | | | Multifocal | 3| 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | DAY ON TEST | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3| | | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 4| 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| DAY ON TEST | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3| | 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 1 2 2 3 2 1 3 3 2 1 1 4 2| Clear Cell Focus | 1 | Degeneration, Cystic | 2 2 2 2 2 2 2 2 2 2| Eosinophilic Focus | 2 1 1 3 1 1 2 1 1| Hyperplasia, Focal | 2 | Hyperplasia, Multifocal | 3 3 | Inflammation, Chronic Active | 3 | Vacuolization Cytoplasmic | 4 3 3 3 | Bile Duct, Hyperplasia | 4 2 3 4 3 2 3 2 3 3 4 3 4 2 3 2 4 2 3 2 3 2 3 2 3| Centrilobular, Degeneration | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 2 2 2 2 2 2 2 2 | Acinus, Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Foreign Body | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Chronic | 3 3 3 3 3 2 2 2 2 2 2 3 3 3 3 2 2 2 3 3 2 2 3 3 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2| Hypertrophy | 2 2 2 2 2 | Vacuolization Cytoplasmic | 4 2 3 2 2 1| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 2 3 2| _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| DAY ON TEST | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3| | 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + M + + M + + + + + + + + + + + + M + M + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 2 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Follicular Cell, Hypertrophy | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | Inflammation, Chronic Active | 2 2 3 2 3 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2| Duct, Dilatation | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 3 3 4 | Metaplasia, Squamous | 2 2 2 2 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 2 2 2 1 | Seminiferous Tubule, Atrophy | 4 | Seminiferous Tubule, Mineralization | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Hyperplasia, Reticulum Cell | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hemorrhage | | __________________________________________________________________________| Lymph Node, Mesenteric | + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | Subcutaneous Tissue, Fibrosis | | _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7| DAY ON TEST | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3| | 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X | Hemorrhage | | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Nerve, Demyelination | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | | Interstitium, Inflammation, Chronic | | Active | 3 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Inflammation, Chronic Active | | Nasolacrimal Duct, Inflammation, | | Chronic Active | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | 4 | Nephropathy, Chronic | 3 2 3 4 2 3 3 2 3 3 3 2 3 2 2 2 3 4 4 4 3 2 3 2 2| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Mucosa, Ulcer | | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7| | | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | | 3 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 2 X 1 1 2 1 2 2 1 1 1 1 1 1 | 27 1.7| Clear Cell Focus | | 1 1.0| Degeneration, Cystic | 2 2 2 2 2 2 3 2 | 18 2.1| Eosinophilic Focus | 1 1 1 1 1 1 1 1 1 | 18 1.2| Hyperplasia, Focal | 2 | 2 2.0| Hyperplasia, Multifocal | | 2 3.0| Inflammation, Chronic Active | | 1 3.0| Vacuolization Cytoplasmic | 3 | 5 3.2| Bile Duct, Hyperplasia | 2 3 4 3 4 3 3 2 2 3 3 2 2 2 2 2 3 3 3 3 3 2 4 | 48 2.8| Centrilobular, Degeneration | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Acinus, Atrophy | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 | 23 2.0| Acinus, Hyperplasia | 3 2 | 2 2.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | | 1 | Foreign Body | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Chronic | 3 2 2 3 3 2 2 2 1 2 3 2 3 3 3 3 2 2 2 1 2 3 3 3 3| 50 2.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 58 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7| | | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Hyperplasia | 2 2 2 2 2 2 2 2 | 19 2.1| Hypertrophy | 2 2 3 | 8 2.1| Vacuolization Cytoplasmic | 1 2 1 2 2 | 11 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 2 2 3 2 2 | 13 2.2| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + M M + + + + + + +| 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Cyst | X | 3 | Pars Distalis, Hyperplasia | 3 2 3 2 3 2 | 9 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| 48 2.0| Follicular Cell, Hypertrophy | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia | 2 | 3 2.0| Inflammation, Chronic Active | 2 2 2 2 4 2 3 4 3 2 2 2 2 2 2 2 3| 37 2.3| Duct, Dilatation | 3 | 1 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 2 2 2 3 2 | 11 2.5| Metaplasia, Squamous | 2 2 2 2 2 2 | 11 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 2 2 2 | 8 1.9| Seminiferous Tubule, Atrophy | 3 3 | 3 3.3| Seminiferous Tubule, Mineralization | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Femoral, Hyperplasia, Reticulum Cell | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Hemorrhage | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | +| 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 59 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7| | | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | 3 2| 2 2.5| __________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + | 39 | Hyperplasia, Cystic | 2 3 2 2 2 2 2 2 2 3 2 2 3 3 2 3 3 | 38 2.2| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 4 | 1 4.0| Subcutaneous Tissue, Fibrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | X X | 3 | Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Peripheral Nerve | + + | 2 | __________________________________________________________________________|____________| Spinal Cord | + + | 2 | Nerve, Demyelination | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar Epithelium, Hyperplasia | 3 | 1 3.0| Interstitium, Inflammation, Chronic | | | Active | 3 | 3 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mucosa, Inflammation, Chronic Active | 3 | 1 3.0| Nasolacrimal Duct, Inflammation, | | | Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydronephrosis | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 60 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7| | | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Nephropathy, Chronic | 2 1 2 3 2 2 2 2 2 2 3 2 2 1 4 3 3 3 2 2 2 2 2 3 2| 50 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | 4 | 1 4.0| Mucosa, Ulcer | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 61 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3| | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + | Dilatation | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + | Dilatation | | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + | __________________________________________________________________________| Intestine Small | + + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + M + + + + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | 1 1 1 1 1 2 1 2 2 1 2 1 1| Clear Cell Focus | 2 | Degeneration, Cystic | 2 2 2 2 2 | Eosinophilic Focus | 4 2 2 2 2 2 X 2 2 2 2 2 3 2 2| Hepatodiaphragmatic Nodule | X X | Hyperplasia, Focal | 3 | Hypertrophy | 1 1 1 | Infarct | 4 | Inflammation, Chronic | 2 | Inflammation, Chronic, Multifocal | 2 | Necrosis | | Vacuolization Cytoplasmic | 1 2 3 2 1 2 1 2 2 2 4 2 2 | Bile Duct, Hyperplasia | 3 2 2 3 4 2 3 3 3 2 3 3 4 3 2 2 3 3 4 3 2 4 3| Centrilobular, Necrosis | | Oval Cell, Hyperplasia | 1 2 | __________________________________________________________________________| Mesentery | + + + | Inflammation, Chronic Active | | __________________________________________________________________________| Pancreas | + + + + + + + + + | Acinus, Atrophy | 3 1 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 3 | Inflammation, Chronic Active | | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | Ulcer | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3| | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + | Degeneration, Chronic | 2 3 2 2 2 | Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + | Hyperplasia | 2 2 2 | Hypertrophy | | Vacuolization Cytoplasmic | 4 2 3 3 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + | Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + | Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 2 2 | Pars Intermedia, Hyperplasia, | | Glandular | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + | C-Cell, Hyperplasia | 4 3 3 2 2 3 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + | Hyperplasia | | Inflammation, Chronic Active | 2 2 2 2 2 3 3 2 | Duct, Dilatation | 3 | __________________________________________________________________________| Prostate | + + + + + + + + + | Inflammation, Chronic Active | 2 1 2 | __________________________________________________________________________| Seminal Vesicle | | Dilatation | | Epithelium, Hyperplasia | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 2 | Seminiferous Tubule, Atrophy | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + | __________________________________________________________________________| Lymph Node | + + + + + + + + + | Mediastinal, Hyperplasia, Macrophage | | _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3| | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mesenteric | + | __________________________________________________________________________| Lymph Node, Thoracic | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | 4 | Capsule, Hemorrhage | | __________________________________________________________________________| Thymus | + + + M + + I M + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + | Hyperplasia, Cystic | 3 2 2 2 3 3 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + | Face, Cyst Epithelial Inclusion | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + | Gliosis | 2 | Hemorrhage | | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Hemorrhage | | Nerve, Demyelination | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + | Alveolar Epithelium, Hyperplasia | | Interstitium, Inflammation, Chronic | | Active | 3 3 | __________________________________________________________________________| Nose | + + + + + + + + + | Mucosa, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Lens, Cataract | 3 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + | Hydronephrosis | 3 | Nephropathy, Chronic | 4 2 4 2 2 2 2 3 1 1 | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| DAY ON TEST | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3| | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Cortex, Cyst | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + | Hemorrhage | | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1| | | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + +| 21 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + +| 21 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A +| 20 | Dilatation | 4| 1 4.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + +| 21 | Dilatation | 4| 1 4.0| Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + +| 21 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + +| 21 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + +| 21 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A +| 19 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + A +| 20 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 1 1 | 4 1.3| Basophilic Focus | 1 2 1 1 1 1 | 19 1.3| Clear Cell Focus | | 1 2.0| Degeneration, Cystic | 2 2 2 2 2 2 3 | 12 2.1| Eosinophilic Focus | 2 1 1 1 3 2 1 2 X 2 2 1 2 2| 29 2.0| Hepatodiaphragmatic Nodule | X X | 4 | Hyperplasia, Focal | | 1 3.0| Hypertrophy | | 3 1.0| Infarct | | 1 4.0| Inflammation, Chronic | 1 2 2 | 4 1.8| Inflammation, Chronic, Multifocal | | 1 2.0| Necrosis | 2 2 | 2 2.0| Vacuolization Cytoplasmic | 2 1 2 2 2 | 18 1.9| Bile Duct, Hyperplasia | 3 3 2 3 4 4 4 3 3 2 3 4 3 2 2 3 3 2 3 2 3 3| 45 2.9| Centrilobular, Necrosis | 3 | 1 3.0| Oval Cell, Hyperplasia | | 2 1.5| __________________________________________________________________________|____________| Mesentery | + + + | 6 | Inflammation, Chronic Active | 4 | 1 4.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + +| 21 | Acinus, Atrophy | 2 2 1 1 | 7 1.7| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + +| 21 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 4 2 | 4 3.0| Inflammation, Chronic Active | 3 | 1 3.0| Ulcer | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 66 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1| | | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | 2 | 1 2.0| Ulcer | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + +| 21 | Degeneration, Chronic | 3 2 2 2 2 3 3| 12 2.3| Thrombosis | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + +| 22 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + +| 21 | Hyperplasia | 2 | 4 2.0| Hypertrophy | 2 | 1 2.0| Vacuolization Cytoplasmic | 2 2 2 1 2 | 10 2.3| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + +| 22 | Hyperplasia | 2 2 | 3 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + +| 21 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + +| 21 | __________________________________________________________________________|____________| Pituitary Gland | + M + + + + + + + + + + + + + +| 27 | Pars Distalis, Cyst | X | 3 | Pars Distalis, Hyperplasia | 3 2 3 | 5 2.4| Pars Intermedia, Hyperplasia, | | | Glandular | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + A + +| 23 | C-Cell, Hyperplasia | 2 3 3 3 2 2 3 3 3 2 3 3| 20 2.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | +| 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + +| 20 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + +| 25 | Hyperplasia | 2 | 1 2.0| Inflammation, Chronic Active | 2 2 2 3 2 2 2| 15 2.2| Duct, Dilatation | 3 4| 3 3.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + +| 21 | Inflammation, Chronic Active | 3 | 4 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 67 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1| | | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Dilatation | 4 | 1 4.0| Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Interstitial Cell, Hyperplasia | 3 | 3 2.3| Seminiferous Tubule, Atrophy | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + +| 21 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + +| 23 | Mediastinal, Hyperplasia, Macrophage | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + | 3 | __________________________________________________________________________|____________| Lymph Node, Thoracic | + | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3| 2 2.5| Hematopoietic Cell Proliferation | 4 | 2 4.0| Capsule, Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + M + + + + + + +| 17 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + | 14 | Hyperplasia, Cystic | 2 2 3 2 2 3 3 | 14 2.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + +| 26 | Face, Cyst Epithelial Inclusion | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + +| 21 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + +| 21 | Gliosis | | 1 2.0| Hemorrhage | 3 3 | 2 3.0| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | Hemorrhage | 3 | 1 3.0| Nerve, Demyelination | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + +| 21 | Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 68 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1| | | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Interstitium, Inflammation, Chronic | | | Active | | 2 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + +| 21 | Mucosa, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + +| 21 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Lens, Cataract | | 1 3.0| Retina, Atrophy | | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + +| 24 | Hydronephrosis | 3 | 2 3.0| Nephropathy, Chronic | 1 3 3 2 3 2 3 3 2 4 2 4 3| 23 2.5| Cortex, Cyst | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + M + +| 20 | Hemorrhage | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 69 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3| | 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + | Parasite Metazoan | | __________________________________________________________________________| Intestine Small | + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 4 | Basophilic Focus | 2 1 1 1 1 1 2 3 2 2 2 2 2 1 1 1 1 1 1 1| Clear Cell Focus | X | Congestion | 3 | Degeneration, Cystic | 2 2 4 2 2 2 2 | Eosinophilic Focus | 1 1 1 2 3 1 4 2 4 2 2 2 4 2 1 2 3 2 2 2 2| Hepatodiaphragmatic Nodule | | Hypertrophy | 2 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1 1 | Inflammation, Chronic, Multifocal | 2 1 1 2 2 2 | Inflammation, Chronic Active | | Necrosis | 1 2 2 | Vacuolization Cytoplasmic | 3 1 2 2 3 2 3 2 3 2 2 2 2 3 2 3 1 2 3 4 2 2 2| Bile Duct, Hyperplasia | 1 3 3 2 3 3 4 2 4 2 4 3 2 3 4 2 2 2 4 2 3 3 2 3 3| Oval Cell, Hyperplasia | 2 3 2 | Portal Vein, Thrombosis | 3 | __________________________________________________________________________| Pancreas | + + + + + + | Fibrosis | 4 | Inflammation, Chronic Active | 4 | Acinus, Atrophy | 1 3 2 | __________________________________________________________________________| Salivary Glands | + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + | Degeneration, Chronic | 3 2 3 2 | Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3| | 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + | Hyperplasia | 2 2 2 | Necrosis | 4 | Vacuolization Cytoplasmic | 3 3 2 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + | Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + | __________________________________________________________________________| Parathyroid Gland | + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + | C-Cell, Hyperplasia | 2 3 2 2 3 3 | Follicle, Cyst | X | Follicular Cell, Hypertrophy | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + | Inflammation, Chronic Active | 2 2 3 4 | __________________________________________________________________________| Prostate | + + + + + + | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Seminal Vesicle | + + | Dilatation | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 | Seminiferous Tubule, Atrophy | 3 2 3| Seminiferous Tubule, Mineralization | 3 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + | Femoral, Atrophy | 3 | __________________________________________________________________________| Lymph Node | + + + + + + + | Mediastinal, Hemorrhage | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Fibrosis | 2 2 | Hematopoietic Cell Proliferation | 3 | Necrosis | | __________________________________________________________________________| Thymus | M + + + + + | _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3| | 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Inflammation, Chronic Active | 4 | Necrosis | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + | Hyperplasia, Cystic | 2 3 3 2 3 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + | Compression | X | Hydrocephalus | 2 | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + | __________________________________________________________________________| Nose | + + + + + + | Mucosa, Inflammation, Chronic Active | | __________________________________________________________________________| Trachea | + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Lens, Cataract | 3 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + | Nephropathy, Chronic | 4 2 2 3 4 2 4 2 | Cortex, Cyst | | __________________________________________________________________________| Urinary Bladder | + + + + + + | Calculus Micro Observation Only | | _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3| | | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 16 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 4.0| Basophilic Focus | 2 2 2 1 2 1 2 1 1 X 1 1 1 2 1 1| 36 1.4| Clear Cell Focus | | 1 | Congestion | | 1 3.0| Degeneration, Cystic | 2 2 2 2 2 | 12 2.2| Eosinophilic Focus | 1 4 3 2 2 1 2 1 3 2 1 3 2 2 3 2 2 2 2| 40 2.1| Hepatodiaphragmatic Nodule | X | 1 | Hypertrophy | 1 1 1 2 1 1 2 1 2 2 1 2 2 2 1 1| 34 1.3| Inflammation, Chronic, Multifocal | 1 1 1 1 2 2 2| 13 1.5| Inflammation, Chronic Active | 2 | 1 2.0| Necrosis | 2 | 4 1.8| Vacuolization Cytoplasmic | 2 2 2 3 2 3 2 2 1 3 4 2 2 2 4 2 3 2 3| 42 2.4| Bile Duct, Hyperplasia | 3 4 4 4 3 3 4 3 2 2 2 3 3 4 3 2 3 3 3 3 2 2 3 4| 49 2.9| Oval Cell, Hyperplasia | 3 | 4 2.5| Portal Vein, Thrombosis | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 16 | Fibrosis | | 1 4.0| Inflammation, Chronic Active | | 1 4.0| Acinus, Atrophy | 2 2 1 2 3 | 8 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Acanthosis | 3 4 | 3 3.3| Inflammation, Chronic Active | 3 | 2 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 73 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3| | | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Degeneration, Chronic | 3 3 3 3 2 | 9 2.7| Thrombosis | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + | 15 | Hyperplasia | 2 | 4 2.0| Necrosis | | 1 4.0| Vacuolization Cytoplasmic | 2 3 2 | 7 2.4| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 16 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + | 22 | Pars Distalis, Cyst | X | 1 | Pars Distalis, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + +| 17 | C-Cell, Hyperplasia | 3 3 3 3 3 3 3 3 3 2 | 16 2.8| Follicle, Cyst | | 1 | Follicular Cell, Hypertrophy | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 16 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + | 20 | Inflammation, Chronic Active | 2 2 2 2 3 2 2 2 3 2 | 14 2.4| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 16 | Inflammation, Chronic Active | 2 | 2 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + | 3 | Dilatation | 3 | 2 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | | 1 2.0| Seminiferous Tubule, Atrophy | 3 2 | 5 2.6| Seminiferous Tubule, Mineralization | 2 | 3 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + M + | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 74 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3| | | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Femoral, Atrophy | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + | 18 | Mediastinal, Hemorrhage | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Depletion Lymphoid | 2 | 1 2.0| Fibrosis | 2 2 2 4 | 6 2.3| Hematopoietic Cell Proliferation | | 1 3.0| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 15 | Inflammation, Chronic Active | | 1 4.0| Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + | 14 | Hyperplasia, Cystic | 3 3 3 3 2 2 | 12 2.6| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + | 22 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 16 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 16 | Compression | X | 2 | Hydrocephalus | 2 | 2 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 17 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 16 | Mucosa, Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 16 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 4 | Lens, Cataract | 3 | 2 3.0| Retina, Atrophy | 4 2 | 3 3.3| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 75 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3| | | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + | 20 | Nephropathy, Chronic | 4 2 3 3 3 4 2 3 3 2 2 | 19 2.8| Cortex, Cyst | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + | 17 | Calculus Micro Observation Only | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 76 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3| | 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + | Dilatation | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + | Parasite Metazoan | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 2 1 1 1 1 2 2 2 1 1 1 2 1 1 2 1| Degeneration, Cystic | 2 2 3 | Eosinophilic Focus | 3 3 2 2 4 3 3 3 2 3 X 2 2 2 3 4 4 3 2 4 3| Hypertrophy | 1 2 2 3 2 2 2 3 3 2 3 3 2 2 3| Inflammation, Chronic, Multifocal | 2 2 2 2 | Inflammation, Chronic Active | | Necrosis | | Vacuolization Cytoplasmic | 2 4 2 2 3 4 2 3 4 2 4 4 4 4 4| Bile Duct, Hyperplasia | 2 3 2 2 4 4 3 4 3 4 2 3 2 3 4 4 3 2 4 3 3 3 3 2| Oval Cell, Hyperplasia | 2 2 2 | __________________________________________________________________________| Mesentery | + | Inflammation, Chronic Active | | Artery, Inflammation, Chronic Active | 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + | Acinus, Atrophy | 1 2 1 3 1 3 2 2 | Acinus, Cytomegaly, Focal | | Duct, Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 3 | Cyst Epithelial Inclusion | X | Inflammation, Chronic Active | 4 3 3 | Ulcer | 3 4 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + | Degeneration, Chronic | 3 2 2 3 3 3 3 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3| | 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + | Hyperplasia | 2 2 2 2 | Hypertrophy | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + | Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + | Pars Distalis, Hyperplasia | 2 2 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + | C-Cell, Hyperplasia | 3 3 3 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + M | Inflammation, Chronic Active | 3 2 2 3 2 2 2 4 | Duct, Dilatation | | __________________________________________________________________________| Prostate | + + + + + + + + + + | Inflammation, Chronic Active | 2 2 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + | __________________________________________________________________________| Lymph Node | + + + + + + + + + + | __________________________________________________________________________| Lymph Node, Mesenteric | + + + | Angiectasis | | __________________________________________________________________________| Lymph Node, Thoracic | + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hematopoietic Cell Proliferation | | Necrosis | 3 | Thrombosis | | __________________________________________________________________________| Thymus | M + + + + + M + + M | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + M + +| Hyperplasia, Cystic | 3 2 3 3 2 2 | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3| | 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + | Acanthosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + | Hemorrhage | 3 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + | __________________________________________________________________________| Trachea | + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + + | Lens, Cataract | 3 4 3 3 | Retina, Atrophy | 4 4 4 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + | Nephropathy, Chronic | 4 4 3 3 4 3 3 2 4 4 4 2 | Cortex, Cyst | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6| | DAY ON TEST | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7| | | 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + M + + + + + + + +| 27 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + A + + + + + + + +| 27 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + A + + + + + + + +| 26 | Dilatation | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + +| 27 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + +| 27 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + A + + + + + + + +| 29 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + +| 27 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + +| 28 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + +| 27 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Basophilic Focus | 1 2 3 2 2 2 1 1 2 2 2 4| 28 1.6| Degeneration, Cystic | 2 2 | 5 2.2| Eosinophilic Focus | 2 2 3 3 2 2 2 3 3 2 2 4 2 3 2 4 2 2 3 3 3 4 3| 44 2.7| Hypertrophy | 3 2 2 2 2 2 2 2 2 2 2 1| 27 2.2| Inflammation, Chronic, Multifocal | 2 2| 6 2.0| Inflammation, Chronic Active | 2 | 1 2.0| Necrosis | 2 | 1 2.0| Vacuolization Cytoplasmic | 3 3 3 2 3 2 2 1 1 2 2 2 2 | 28 2.7| Bile Duct, Hyperplasia | 4 3 4 2 3 2 4 3 3 4 2 3 2 3 3 2 3 4 3 2 4 2 3 2| 48 3.0| Oval Cell, Hyperplasia | 1 1 2 2 2 2 2 2 | 11 1.8| __________________________________________________________________________|____________| Mesentery | + + | 3 | Inflammation, Chronic Active | 2 | 1 2.0| Artery, Inflammation, Chronic Active | 3 | 2 3.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + A + + + + + + + +| 27 | Acinus, Atrophy | 3 1 4 2 2 | 13 2.1| Acinus, Cytomegaly, Focal | 2 | 1 2.0| Duct, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + M + + + + + + + +| 27 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Acanthosis | 2 3 3 3 4| 7 3.0| Cyst Epithelial Inclusion | | 1 | Inflammation, Chronic Active | 3 2 3| 6 3.0| Ulcer | 2 2| 5 2.8| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 | Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Tooth | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6| | DAY ON TEST | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7| | | 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + M + + + + + + + +| 27 | Degeneration, Chronic | 3 2 3 3 3 3 2 2 2 2 3 3 3 3 3| 23 2.7| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + +| 29 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + A + + + + + + + +| 28 | Hyperplasia | 2 2 2 2 2| 9 2.0| Hypertrophy | 2 | 1 2.0| Vacuolization Cytoplasmic | 2 2 2 3 2 2| 6 2.2| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +| 29 | Hyperplasia | 2 2 3 2 2| 6 2.2| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + +| 27 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M + + + + + + + +| 27 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + I + + + + + + + +| 32 | Pars Distalis, Hyperplasia | 2 2 2 3 1 | 8 2.1| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + M + + + + + + + + +| 28 | C-Cell, Hyperplasia | 3 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 3 3| 28 2.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + +| 28 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + +| 32 | Inflammation, Chronic Active | 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2| 27 2.2| Duct, Dilatation | 3 2| 2 2.5| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + +| 28 | Inflammation, Chronic Active | 2 1 1 2 3| 8 1.9| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 2 2 | 3 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + A + + + + + + + +| 27 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + M + + + + + + + +| 27 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + +| 9 | Angiectasis | 3| 1 3.0| __________________________________________________________________________|____________| Lymph Node, Thoracic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6| | DAY ON TEST | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7| | | 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 | Fibrosis | 4 2 2 | 4 2.5| Hematopoietic Cell Proliferation | 3 | 1 3.0| Necrosis | 2 | 2 2.5| Thrombosis | 3 | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + I + + + M M + + + + + + +| 22 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + +| 23 | Hyperplasia, Cystic | 3 3 2 3 3 2 3 2 3 2 3 3 4| 19 2.7| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + +| 31 | Acanthosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + +| 28 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + +| 29 | Hemorrhage | 2 2 | 4 2.3| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + M + + + + + + + +| 28 | Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + A + + + + + + + +| 27 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + M + + + + + + + +| 27 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + +| 7 | Lens, Cataract | 3 3 3| 7 3.1| Retina, Atrophy | 4 4 4| 7 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + +| 32 | Nephropathy, Chronic | 4 2 3 3 3 3 3 4 3 3 3 3 4 4 4 2 4 4 4 4| 32 3.3| Cortex, Cyst | X | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + A + + + + + + + +| 27 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7| DAY ON TEST | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3| | 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + | Inflammation, Chronic Active | | Ulcer | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + M + + + + + + + + + | Parasite Metazoan | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + M + + + + + + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 1 3 1 1 | Degeneration, Cystic | 2 2 2| Eosinophilic Focus | 4 3 4 4 2 4 1 1 4 3 3 3 4 3 3 4 4 2 3 3 4| Hypertrophy | 2 2 2 3 3 2 3 2 1 2 2 2 2 2 2 2 2 2 2 2| Inflammation, Chronic, Multifocal | 2 2 2 | Inflammation, Chronic Active | 1 | Necrosis | 3 | Vacuolization Cytoplasmic | 2 2 3 1 1 2 3 4 2 2 2 3 2 3| Bile Duct, Hyperplasia | 3 4 3 4 3 2 2 4 2 4 3 4 3 2 4 2 3 3 3 3 4 3 2 4| Oval Cell, Hyperplasia | 2 2 2 2 2 2 2 2| __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + | Acinus, Atrophy | 2 3 | Acinus, Hyperplasia | | __________________________________________________________________________| Salivary Glands | + M + + + + + + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 2 3 | Inflammation, Chronic | 2 | Inflammation, Chronic Active | 3 3 3 | Mineralization | 1 | Ulcer | 2 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Dysplasia | | Inflammation, Chronic Active | 2 | Mineralization | 2 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 83 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7| DAY ON TEST | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3| | 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Degeneration, Chronic | 2 2 2 2 2 3 2 3 2 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + | Degeneration, Cystic | 2 | Hyperplasia | 2 2 2 | Necrosis | | Vacuolization Cytoplasmic | 2 2 2 2 2 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + | Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia | 2 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + | C-Cell, Hyperplasia | 2 3 1 2 2 2 2 3 2 2 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + | Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 3 | Duct, Dilatation | | Duct, Hyperplasia, Squamous | 3 2 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + | Inflammation, Acute | | Inflammation, Chronic Active | 2 2 | Metaplasia, Squamous | | __________________________________________________________________________| Seminal Vesicle | | Dilatation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 2 2 | Seminiferous Tubule, Atrophy | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node | + + M + + + + + + + + + + + | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + | __________________________________________________________________________| Lymph Node, Thoracic | + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 84 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7| DAY ON TEST | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3| | 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Fibrosis | | Inflammation, Chronic Active | 3 | __________________________________________________________________________| Thymus | + + + + + M + + + + + M I | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + | Hyperplasia, Cystic | 2 2 2 3 2 2 2 3 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + | Compression | X | Hemorrhage | | Hydrocephalus | 2 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + | Interstitium, Inflammation, Chronic | | Active | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + | Foreign Body | | Mucosa, Inflammation, Acute | | Mucosa, Inflammation, Chronic Active | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Lens, Cataract | 3 3 | Retina, Atrophy | 4 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + | Nephropathy, Chronic | 3 3 4 3 2 2 4 3 4 4 3 4 4 4 | Cortex, Cyst | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + | Inflammation, Acute | | _____________________________________________________________________________________________________________________| Page 85 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6| | DAY ON TEST | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9| | | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + +| 31 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + +| 31 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + +| 30 | Inflammation, Chronic Active | 2 | 1 2.0| Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| 31 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| 30 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + +| 31 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| 31 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + +| 29 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| 30 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 2 1 1 2| 8 1.5| Degeneration, Cystic | | 3 2.0| Eosinophilic Focus | 4 1 4 3 X 4 4 2 2 3 3 4 4 1 2 3 2 2 3 3 2| 42 3.0| Hypertrophy | 2 2 2 2 2 3 2 2 2 | 29 2.1| Inflammation, Chronic, Multifocal | 2 | 4 2.0| Inflammation, Chronic Active | | 1 1.0| Necrosis | 3 | 2 3.0| Vacuolization Cytoplasmic | 3 2 4 2 1 3 3 4 2 2 2 2 3 2| 28 2.4| Bile Duct, Hyperplasia | 4 2 4 3 2 3 3 4 3 2 2 3 4 3 3 4 4 3 2 3 2 3 4 | 47 3.1| Oval Cell, Hyperplasia | 2 2 2 2 2 | 13 2.0| __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + +| 32 | Acinus, Atrophy | 2 4 2 3 1 1 2 3 2 3 | 12 2.3| Acinus, Hyperplasia | 2| 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + +| 30 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 2 3 3| 7 2.6| Inflammation, Chronic | | 1 2.0| Inflammation, Chronic Active | 3 3| 5 3.0| Mineralization | | 1 1.0| Ulcer | 3| 3 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dysplasia | 2 | 1 2.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 86 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6| | DAY ON TEST | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9| | | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Mineralization | | 1 2.0| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + +| 31 | Degeneration, Chronic | 2 2 3 2 3 2 2 3 2 2 2 3 | 22 2.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + +| 32 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + + +| 31 | Degeneration, Cystic | | 1 2.0| Hyperplasia | 2 2 | 5 2.0| Necrosis | 2 | 1 2.0| Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 2 2 | 15 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +| 32 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| 31 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + +| 31 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + I + + + + +| 30 | Pars Distalis, Cyst | X X| 2 | Pars Distalis, Hyperplasia | 2 2 3 2 | 6 2.2| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + +| 31 | C-Cell, Hyperplasia | 3 2 3 2 2 2 2 2 3 2 3 3 3 3 2 3 2 3| 30 2.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + +| 30 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + M + + + + + + + + + + + + + +| 34 | Inflammation, Chronic Active | 2 2 2 1 3 2 2 1 2 2 2 2 3| 23 2.0| Duct, Dilatation | 3 | 1 3.0| Duct, Hyperplasia, Squamous | 3 | 3 2.7| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + M + + + +| 30 | Inflammation, Acute | 3 | 1 3.0| Inflammation, Chronic Active | 2 4 2 | 5 2.4| Metaplasia, Squamous | 2 | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + | 1 | Dilatation | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 87 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6| | DAY ON TEST | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9| | | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 | 9 2.0| Seminiferous Tubule, Atrophy | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + +| 31 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + +| 33 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 8 | __________________________________________________________________________|____________| Lymph Node, Thoracic | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 3 | 2 2.5| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Thymus | + M + + + M + + + + + + + + M + + M M| 24 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + | 20 | Hyperplasia, Cystic | 2 2 2 2 2 3 2 3 3 2 2 | 20 2.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + +| 32 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + +| 31 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + +| 31 | Compression | | 1 | Hemorrhage | 2 2 | 2 2.0| Hydrocephalus | | 2 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + +| 32 | Interstitium, Inflammation, Chronic | | | Active | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + +| 31 | Foreign Body | 2| 1 2.0| Mucosa, Inflammation, Acute | 2| 1 2.0| Mucosa, Inflammation, Chronic Active | 2 2 | 2 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + +| 31 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 88 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6| | DAY ON TEST | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9| | | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | + + | 4 | Lens, Cataract | 3 3 | 4 3.0| Retina, Atrophy | 4 4 | 4 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + +| 32 | Nephropathy, Chronic | 3 3 3 1 3 3 4 3 4 4 3 3 2 3 3 4 4 4| 32 3.3| Cortex, Cyst | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + +| 31 | Inflammation, Acute | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 89 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| DAY ON TEST | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3| | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + + + A + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + A + + + + | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + | Ulcer | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + | Parasite Metazoan | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 2 2 2 1 1 2 1 1| Clear Cell Focus | | Degeneration, Cystic | 2 2 2 2 2 | Eosinophilic Focus | 4 4 4 2 4 3 3 4 3 3 4 3 2 3 3 4 2 2 4 4 3 3 1 3 3| Hypertrophy | 3 2 2 2 2 1 2 1 2 2 2 1 2| Inflammation, Chronic | 2 | Inflammation, Chronic, Multifocal | 2 1 | Necrosis | 2 | Vacuolization Cytoplasmic | 3 3 4 3 4 3 3 2 3 2 4 4 2 4 2 3| Bile Duct, Hyperplasia | 3 4 3 3 3 3 3 2 3 4 3 2 2 2 3 4 4 2 3 3 4 2 3 3 3| Oval Cell, Hyperplasia | 2 2 2 2 2 2 2 2 1 2 2 2 2 | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + | Necrosis | | Acinus, Atrophy | 3 1 1 3 2 3 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + M + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 3 3 | Erosion | | Inflammation, Chronic | 1 | Inflammation, Chronic Active | 3 3 | Ulcer | 4 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Mineralization | 2| Ulcer | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + | Degeneration, Chronic | 3 2 3 3 3 2 3 2 2 2 3 | Thrombosis | X | _____________________________________________________________________________________________________________________| Page 90 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| DAY ON TEST | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3| | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + | Atrophy | | Degeneration, Cystic | | Hyperplasia | 2 2 | Hypertrophy | 2 2 | Vacuolization Cytoplasmic | 2 1 2 2 3 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + | Hyperplasia | 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + | Hyperplasia | 2 | Necrosis | | __________________________________________________________________________| Parathyroid Gland | M + + + + + + M + + + + + | Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + | Pars Distalis, Cyst | X | Pars Distalis, Hemorrhage | 4 | Pars Distalis, Hyperplasia | 2 1 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + | C-Cell, Hyperplasia | 3 3 3 3 2 2 3 2 2 2 3 2 3 | Follicle, Cyst | | Follicular Cell, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + | Inflammation, Chronic Active | 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + | Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 3 | Duct, Dilatation | 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + | Inflammation, Chronic Active | 3 3 1 2 4 | Metaplasia, Squamous | 1 3 | __________________________________________________________________________| Seminal Vesicle | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 | Seminiferous Tubule, Atrophy | 3 4 | Seminiferous Tubule, Mineralization | 3 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 91 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| DAY ON TEST | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3| | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + | Femoral, Myelofibrosis | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + M + + + + | Mandibular, Hyperplasia, Lymphoid | 3 | Mediastinal, Congestion | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + | __________________________________________________________________________| Lymph Node, Thoracic | + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Cyst | | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + | Depletion Lymphoid | | Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + | Hyperplasia, Cystic | 2 3 3 2 2 2 2 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + | Compression | X X X X | Hemorrhage | | Hydrocephalus | 3 2 2 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + | Mucosa, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic Active | | Lens, Cataract | | Retina, Atrophy | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + | Nephropathy, Chronic | 2 4 2 4 3 4 4 3 2 4 3 4 3 4 3 4 | Cortex, Cyst | | _____________________________________________________________________________________________________________________| Page 92 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| DAY ON TEST | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3| | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + | Hemorrhage | 4 | Mucosa, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| Page 93 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6| | DAY ON TEST | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7| | | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + +| 31 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + +| 30 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + +| 29 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| 30 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| 30 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + +| 31 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + +| 30 | Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + +| 29 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| 30 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 1 2 2 1 3 1 1 | 15 1.5| Clear Cell Focus | 2 | 1 2.0| Degeneration, Cystic | 2 2| 7 2.0| Eosinophilic Focus | 3 3 1 3 4 4 2 2 4 2 2 2 3 3 3 4 3 3 1 3 3 3| 47 3.0| Hypertrophy | 3 2 1 2 2 2 2 2 1 2 2 2 2 2 | 27 1.9| Inflammation, Chronic | 2 | 2 2.0| Inflammation, Chronic, Multifocal | 2 3 | 4 2.0| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | 3 3 2 3 3 2 3 3 2 2 2 2 2 2 2 2| 32 2.7| Bile Duct, Hyperplasia | 4 2 2 4 2 3 2 2 3 3 3 2 3 3 2 3 3 2 4 3 3 3 4 2| 49 2.9| Oval Cell, Hyperplasia | 1 1 2 3 3 2 2 3 2 2 | 23 2.0| __________________________________________________________________________|____________| Mesentery | + | 2 | __________________________________________________________________________|____________| Pancreas | + A + + + + + + + + + + + + + + + +| 31 | Necrosis | 4 | 1 4.0| Acinus, Atrophy | 2 1 4 2 2 1 2 2 2| 16 2.1| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + +| 30 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 3 3 2 3 | 8 2.9| Erosion | 2 | 1 2.0| Inflammation, Chronic | | 1 1.0| Inflammation, Chronic Active | 3 3 3 | 5 3.0| Ulcer | 3 | 4 3.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | 2| 1 2.0| Mineralization | | 1 2.0| Ulcer | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 94 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6| | DAY ON TEST | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7| | | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + +| 31 | Degeneration, Chronic | 3 3 2 3 2 2 2 3 2 3 2 2| 23 2.5| Thrombosis | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + M + + + + + + + + + + + + + + + +| 30 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + M + + + + + + + + + + + + + + + +| 30 | Atrophy | 3 | 1 3.0| Degeneration, Cystic | 2 | 1 2.0| Hyperplasia | 2 2 | 4 2.0| Hypertrophy | | 2 2.0| Vacuolization Cytoplasmic | 2 2 3 1 2 2 2 2 2| 14 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + +| 30 | Hyperplasia | 2 2 | 3 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + A + + + + + + + + + + + + + + + +| 30 | Hyperplasia | | 1 2.0| Necrosis | 4 | 1 4.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + +| 29 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + +| 34 | Pars Distalis, Cyst | | 1 | Pars Distalis, Hemorrhage | | 1 4.0| Pars Distalis, Hyperplasia | 3 3 2 2 2| 8 2.3| __________________________________________________________________________|____________| Thyroid Gland | + A + + + + + + + + + + + + + + + +| 30 | C-Cell, Hyperplasia | 3 3 3 2 3 2 3 2 3 2 3 3 3 3 3 3| 29 2.7| Follicle, Cyst | X | 1 | Follicular Cell, Hyperplasia | | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + +| 30 | Inflammation, Chronic Active | 2 | 2 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + +| 32 | Inflammation, Chronic Active | 3 4 2 3 2 2 2 2 2 3 2 2 2 4 | 25 2.3| Duct, Dilatation | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 95 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6| | DAY ON TEST | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7| | | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + +| 31 | Inflammation, Chronic Active | 2 1 2 1 2 | 10 2.1| Metaplasia, Squamous | 1 | 3 1.7| __________________________________________________________________________|____________| Seminal Vesicle | + | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 2 1 2 | 4 1.8| Seminiferous Tubule, Atrophy | 3 | 3 3.3| Seminiferous Tubule, Mineralization | | 2 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + A + + + + + + + + + + + + + + + +| 30 | Femoral, Myelofibrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + M + + + + + + + + + + + + + + + +| 31 | Mandibular, Hyperplasia, Lymphoid | 4 3 | 3 3.3| Mediastinal, Congestion | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 4 | __________________________________________________________________________|____________| Lymph Node, Thoracic | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Cyst | X | 1 | __________________________________________________________________________|____________| Thymus | + + + M + + M + M + + + + + + + + +| 27 | Depletion Lymphoid | 4 | 1 4.0| Necrosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + M + + M| 18 | Hyperplasia, Cystic | 2 2 3 2 2 2 2 3 3 2 | 18 2.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + +| 32 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + +| 31 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + +| 31 | Compression | | 4 | Hemorrhage | 3 | 1 3.0| Hydrocephalus | | 4 2.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + +| 31 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 96 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6| | DAY ON TEST | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7| | | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + A + + + + + + + + + + + + + + + +| 30 | Mucosa, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + +| 31 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | Cornea, Inflammation, Chronic Active | 3 | 1 3.0| Lens, Cataract | 4 3 | 2 3.5| Retina, Atrophy | 4 4 | 2 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + +| 37 | Nephropathy, Chronic | 4 4 2 4 3 3 4 4 3 3 4 3 3 3 4 2 4 2 3 3| 36 3.3| Cortex, Cyst | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + A + + + + + + + + + + + + + + + +| 30 | Hemorrhage | | 1 4.0| Mucosa, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 97 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3| | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | 2 2 | Clear Cell Focus | 2 | Degeneration, Cystic | 3 | Eosinophilic Focus | 4 3 4 4 4 4 3 4 4 4 4 4 4 3 4 4 4 4 4 4 4 3 4 4| Hypertrophy | 3 2 2 2 2 2 2 2 2| Inflammation, Chronic, Multifocal | 2 2| Metaplasia | | Necrosis | 3 | Vacuolization Cytoplasmic | 1 1 2 2 2 3 2 2 3 3 3 3 2 2 2 1 3 | Bile Duct, Hyperplasia | 3 4 3 3 4 3 3 2 2 3 2 2 4 3 2 3 3 3 3 3 3 3 2 3 3| Oval Cell, Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2| __________________________________________________________________________| Mesentery | + + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 4 2 1 2 3 3 3 3 2 1 2 4 2 4 2 3 3 2 3 2 | Acinus, Cytomegaly | 2 | Acinus, Hyperplasia | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis, Focal | 4 | Acanthosis | 4 2 4 3 3 | Cyst Epithelial Inclusion | | Inflammation, Chronic Active | 3 2 3 3 3 | Ulcer | 2 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Mineralization | | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 98 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3| | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Degeneration, Chronic | 2 3 2 2 2 2 2 2 2 2 2 3 3 2 3 3 2 3 2 2 2 3 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 3 3| Hypertrophy | 2 2 1 2 2 | Necrosis | 3 | Vacuolization Cytoplasmic | 2 2 2 2| Capsule, Ectopic Tissue | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Hyperplasia | 2 | Hypertrophy | 1 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 3 2 2 2 2 2 2| Pars Distalis, Vacuolization | | Cytoplasmic | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | C-Cell, Hyperplasia | 2 2 3 3 2 2 2 2 3 2 2 3 2 3 2 2 2 2 2 2 3 2 2 2 3| Follicular Cell, Cytoplasmic | | Alteration | | Follicular Cell, Hypertrophy | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 | __________________________________________________________________________| Preputial Gland | + + M + + + M + + M + + + + + + + + + + + + + M +| Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 | Duct, Dilatation | 3 3 | Duct, Hyperplasia, Squamous | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Inflammation, Chronic Active | 2 2 2| Metaplasia, Squamous | 2 2| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 2 | _____________________________________________________________________________________________________________________| Page 99 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3| | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Seminiferous Tubule, Atrophy | 3 4 3 4 3 | Seminiferous Tubule, Mineralization | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + | Mandibular, Hyperplasia, Lymphoid | 3 | Mandibular, Inflammation, Chronic, | | Multifocal | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 | Thrombosis, Multiple | X | __________________________________________________________________________| Thymus | + + + + + M + M + + + + + M M + + + + M + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 2 2 2 1 2 2 2 2 3 2 2 3 2 2 3 3 2 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 2 | Interstitium, Inflammation, Chronic | | Active | | __________________________________________________________________________| Nose | + + M + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic Active | | Lens, Cataract | 3 | Retina, Atrophy | 4 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 100 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| DAY ON TEST | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3| | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Inflammation, Chronic, Multifocal | 2 | Nephropathy, Chronic | 2 4 3 2 2 3 2 3 4 4 3 4 4 3 3 3 3 3 3 3 2 3 3 4 3| Cortex, Cyst | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 101 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3| | | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Basophilic Focus | 2 X 2 2 2 2 | 8 2.0| Clear Cell Focus | | 1 2.0| Degeneration, Cystic | | 1 3.0| Eosinophilic Focus | 4 4 4 4 4 3 4 3 3 4 4 3 4 4 3 2 4 3 3 4 4 4| 46 3.7| Hypertrophy | 3 2 3 2 2 3 2 1 | 17 2.2| Inflammation, Chronic, Multifocal | 2 2 | 4 2.0| Metaplasia | 1 | 1 1.0| Necrosis | | 1 3.0| Vacuolization Cytoplasmic | 2 3 3 2 2 2 1 2 4 2 2 3 2 2 3 2 2 | 34 2.2| Bile Duct, Hyperplasia | 3 3 4 3 3 2 2 2 3 3 3 2 3 3 3 3 4 2 2 2 3 3 2 3| 49 2.8| Oval Cell, Hyperplasia | 3 2 3 2 2 2 2 2 1 3 2 3 2 2 1 2 2 4 3| 37 2.2| __________________________________________________________________________|____________| Mesentery | | 5 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | 2 3 3 2 2 2 3 2 2 2 3 2 3 2 2 | 35 2.5| Acinus, Cytomegaly | | 1 2.0| Acinus, Hyperplasia | 3 | 2 2.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis, Focal | | 1 4.0| Acanthosis | 3 3 3 3 2 3 | 11 3.0| Cyst Epithelial Inclusion | X | 1 | Inflammation, Chronic Active | 3 3 2 3 | 9 2.8| Ulcer | 3 2 2 | 6 2.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 102 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3| | | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Chronic | 2 2 2 3 2 1 2 2 3 2 2 2 2 2 2 2 3| 40 2.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 3 3 2 2 2 2 2 2 | 17 2.2| Hypertrophy | 2 2 | 7 1.9| Necrosis | | 1 3.0| Vacuolization Cytoplasmic | 2 2 4 3 2 2 | 10 2.3| Capsule, Ectopic Tissue | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 | 4 2.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | | 1 | Hyperplasia | 2 | 2 2.0| Hypertrophy | | 1 1.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + M A + + + + + + + + + + + + + +| 48 | Pars Distalis, Hyperplasia | 3 2 3 | 10 2.3| Pars Distalis, Vacuolization | | | Cytoplasmic | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 | Inflammation, Chronic | | 1 2.0| C-Cell, Hyperplasia | 2 3 2 2 3 2 2 2 2 2 3 2 2 3 3 3 2 2 3 2 2 3| 47 2.3| Follicular Cell, Cytoplasmic | | | Alteration | 2 | 1 2.0| Follicular Cell, Hypertrophy | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 2 | 3 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 103 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3| | | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + M + + + + + + + + + + + + + + +| 44 | Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3| 34 2.0| Duct, Dilatation | 2 | 3 2.7| Duct, Hyperplasia, Squamous | 3 3| 2 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Dilatation | 3 | 1 3.0| Inflammation, Chronic Active | 2 3 2 2 | 7 2.1| Metaplasia, Squamous | 2 | 3 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 1 2 2 2 2 | 7 1.9| Seminiferous Tubule, Atrophy | 3 | 6 3.3| Seminiferous Tubule, Mineralization | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mandibular, Hyperplasia, Lymphoid | | 1 3.0| Mandibular, Inflammation, Chronic, | | | Multifocal | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 2 2 3 2 2 2 2 | 10 2.2| Thrombosis, Multiple | | 1 | __________________________________________________________________________|____________| Thymus | M + + + + + + M + + + + M + + + + + M + + + + + +| 40 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + +| 39 | Hyperplasia, Cystic | 2 2 3 3 3 3 2 3 2 2 3 3 2 3 2 2 2| 37 2.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 4| 1 4.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 104 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7| | DAY ON TEST | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3| | | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar Epithelium, Hyperplasia | 2 3 2 | 4 2.3| Interstitium, Inflammation, Chronic | | | Active | 2 3 | 2 2.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mucosa, Inflammation, Chronic Active | 2 1 | 3 1.7| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + + | 5 | Cornea, Inflammation, Chronic Active | 4 | 1 4.0| Lens, Cataract | 3 3 | 3 3.0| Retina, Atrophy | 4 4 | 3 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic, Multifocal | | 1 2.0| Nephropathy, Chronic | 2 3 3 4 3 3 2 4 4 3 1 3 3 4 4 4 3 3 2 3 4 3 3 3 3| 50 3.1| Cortex, Cyst | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + A + + + + + + + + M + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 105 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| DAY ON TEST | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5| | 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + M + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 2 1 2 1 | Clear Cell Focus | X | Congestion | | Degeneration, Cystic | 2 2 2 | Eosinophilic Focus | 4 4 4 4 4 4 3 4 3 4 4 4 4 4 4 4 4 4 3 4 4 4 4 3| Fibrosis | 3 | Hypertrophy | 2 1 3 2 2 2 2 2 2 2 1 | Infarct | 3 | Inflammation, Chronic, Multifocal | 2 1 1 | Metaplasia | | Necrosis | 3 1 | Vacuolization Cytoplasmic | 2 2 2 2 2 1 1 2 3 2 2 2 1 2 3 2 1 2 2 2 | Bile Duct, Cyst | | Bile Duct, Hyperplasia | 3 3 4 4 4 3 3 3 2 3 3 3 3 4 4 3 3 3 3 4 3 4 3 3 4| Oval Cell, Hyperplasia | 2 2 2 3 3 1 2 2 2 2 2 4 2 2 2 2 3 2 2 3 1 3| Serosa, Fibrosis | | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 4 2 2 4 3 4 2 2 3 2 2 2 2 2| Acinus, Hyperplasia | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 | Erosion | | Inflammation, Chronic Active | | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Ulcer | 2 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 106 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| DAY ON TEST | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5| | 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Degeneration, Chronic | 2 2 2 2 3 2 2 3 3 2 3 2 3 2 3 2 2 2 2 2 | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Spindle Cell, Hyperplasia | 2 | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 2 2 2 2 2 | Hypertrophy | | Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + A + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia | 2 2 1 2 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 1 2 3 3 3 2 2 2 1 1 2 2 3 2 3 3 3 2 3 3 3 3 3| Follicle, Cyst | X| Follicle, Hyperplasia, Cystic | 3 | Follicular Cell, Hyperplasia | 2 | Follicular Cell, Hypertrophy | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 2 | __________________________________________________________________________| Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 1 2 2 2 3 3 2 3 2 3 2 2 2 3 2 2 2 | Duct, Dilatation | 3 3 3 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 2 2 2 2 | Metaplasia, Squamous | 2 3 2 2 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 2 2 2 | Seminiferous Tubule, Atrophy | 4 2 4 1 4 3 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Femoral, Hyperplasia, Neutrophil | 3 | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 107 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 _____________________________________________________________________________________________________________________ | 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| DAY ON TEST | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5| | 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Sinus, Mandibular, Ectasia | | __________________________________________________________________________| Lymph Node, Mesenteric | + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 | Hematopoietic Cell Proliferation | 3 | __________________________________________________________________________| Thymus | I + M + + + M M + M I + + + M M M + + + + M M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Compression | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia | 3 | Bronchiole, Epithelium, Hyperplasia | | Interstitium, Inflammation, Chronic | | Active | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Subacute | | Mucosa, Inflammation, Chronic Active | 3 2 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + +| Lens, Cataract | 3 | Retina, Atrophy | 4 | __________________________________________________________________________| Harderian Gland | + | Acinus, Atrophy | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic | 3 2 2 3 4 3 3 4 2 2 3 2 3 2 2 2 3 3 3 3 3 3 4 3 3| Cortex, Cyst | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 108 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7| | DAY ON TEST | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3| | | 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + M + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 1 | 5 1.4| Clear Cell Focus | | 1 | Congestion | 3 | 1 3.0| Degeneration, Cystic | | 3 2.0| Eosinophilic Focus | 4 4 4 4 4 3 4 2 4 3 2 4 4 3 3 2 4 3 4 4 4 4| 46 3.7| Fibrosis | 3 | 2 3.0| Hypertrophy | 4 2 3 2| 15 2.1| Infarct | 4 | 2 3.5| Inflammation, Chronic, Multifocal | 2 2 | 5 1.6| Metaplasia | 1 | 1 1.0| Necrosis | 2 4 | 4 2.5| Vacuolization Cytoplasmic | 3 2 1 2 2 3 2 2 2 3 2 2 2 2 3 3 2| 37 2.1| Bile Duct, Cyst | X | 1 | Bile Duct, Hyperplasia | 4 3 2 3 4 3 4 4 4 3 3 3 3 3 3 3 3 2 3 3 3 3 4 2| 49 3.2| Oval Cell, Hyperplasia | 1 2 2 2 2 1 2 2 2 3 2 2 3 2 3 2 3 4 2| 41 2.2| Serosa, Fibrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 4 2 3 2 2 2 2 3 2 2 4 2 3 2| 29 2.5| Acinus, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 2 4 3 2 | 6 2.7| Erosion | 2 | 1 2.0| Inflammation, Chronic Active | 1 3 3 | 3 2.3| Ulcer | 3 3 | 2 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 109 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7| | DAY ON TEST | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3| | | 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Erosion | 3 | 1 3.0| Ulcer | 2 | 3 2.3| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Degeneration, Chronic | 2 2 2 2 2 3 2 1 3 3 3 2 2 2| 34 2.3| Atrium, Thrombosis | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Capsule, Spindle Cell, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 2 | 13 2.1| Hypertrophy | 2 2 | 2 2.0| Vacuolization Cytoplasmic | 2 2 2 3 3 | 15 2.1| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 2 | 5 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 3 | 4 2.3| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M M + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Hyperplasia | 2 3 3 3 2 | 10 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 2 3 3 2 3 2 3 2 2 2 2 3 2 2 2 2 3 2 3 3 2 2 2| 48 2.4| Follicle, Cyst | | 1 | Follicle, Hyperplasia, Cystic | | 1 3.0| Follicular Cell, Hyperplasia | | 1 2.0| Follicular Cell, Hypertrophy | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 | 3 2.7| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 2 4 2 2 2 3 2 2 2 3 2 2 2 2 2 2 2 2| 36 2.2| Duct, Dilatation | 3 3 | 6 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 110 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7| | DAY ON TEST | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3| | | 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | 2 3 3 2 | 10 2.2| Metaplasia, Squamous | 2 2 3 | 8 2.3| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 | 12 2.0| Seminiferous Tubule, Atrophy | 4 4 4 3 | 11 3.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Femoral, Hyperplasia, Neutrophil | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Sinus, Mandibular, Ectasia | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 2 3 2 | 6 2.2| Hematopoietic Cell Proliferation | | 1 3.0| __________________________________________________________________________|____________| Thymus | + M M M M + + M + + M + M + + + + M + M + + + M M| 28 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + +| 30 | Hyperplasia, Cystic | 2 2 2 2 4 3 3 2 2 2 2 2 3 2| 30 2.1| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Compression | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Alveolar Epithelium, Hyperplasia | 1 | 2 2.0| Bronchiole, Epithelium, Hyperplasia | 4 | 1 4.0| Interstitium, Inflammation, Chronic | | | Active | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage, Subacute | 3 | 1 3.0| Mucosa, Inflammation, Chronic Active | | 5 2.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 111 NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97 Route: DOSED FEED Time: 10:20:16 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7| | DAY ON TEST | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3| | | 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | 10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 4 | Lens, Cataract | | 1 3.0| Retina, Atrophy | | 1 4.0| __________________________________________________________________________|____________| Harderian Gland | | 1 | Acinus, Atrophy | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy, Chronic | 2 2 3 3 3 3 4 4 2 4 4 3 4 2 3 3 2 3 4 4 2 2 2 3 2| 50 2.9| Cortex, Cyst | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mucosa, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 112 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