TDMS Study 05077-01 Pathology Tables
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
Facility: Battelle Columbus Laboratory
Chemical CAS #: 67774-32-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3|
| 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 1 2 2 2 2 3 2 2 2 2 2 3 2 1 3 2 2 2 2 X X|
Clear Cell Focus | X X |
Eosinophilic Focus | 1 1 |
Hematopoietic Cell Proliferation | 3 |
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic Active | 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 1 2 |
Necrosis | 1 1 |
Vacuolization Cytoplasmic | 4 4 |
Bile Duct, Hyperplasia | 1 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + I + +|
Acinus, Atrophy | 1 1 2 2 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 2 2 2 2 2 2 2 2 2 1 2 3 2 2 1 2 2 2 2 3 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 3 2 2 2 2 3 2 2 2 2 2 2 2 2|
Hypertrophy | 2 2 2 2 2 3 |
Vacuolization Cytoplasmic | 2 2 2 2 2 1 1 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3|
| 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + I + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X |
Pars Distalis, Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 3 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 1 2 |
Duct, Dilatation | 3 3 3 3 3 3 3 3 3 3 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
Follicle, Cyst | X |
Periovarian Tissue, Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 3 2 3|
Cervix, Cyst | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia | 3 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Histiocyte | 3 |
Sinus, Ectasia | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M M + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 3 2 2 3 3 3 2 3 3 3 3 2 3 2 3 2 3 3 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3|
| 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X X X |
Necrosis | 3 |
__________________________________________________________________________|
Spinal Cord | + + |
Nerve, Demyelination | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 3 2 3 |
Retina, Atrophy | 4 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 2 1 1 1 2 2 2 3|
Renal Tubule, Mineralization | 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| |
| 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2| 47 2.0|
Clear Cell Focus | 2 | 3 2.0|
Eosinophilic Focus | 3| 3 1.7|
Hematopoietic Cell Proliferation | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Chronic Active | 1 2 2 3 1 2 2 2 2 2 2 2 2 2 2 1 | 34 1.9|
Necrosis | 1 | 3 1.0|
Vacuolization Cytoplasmic | 2 | 3 3.3|
Bile Duct, Hyperplasia | 2 1 2 1 2 2 2 2 1 3 1 3| 14 1.8|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 2 1 2 2 1 2 3 | 15 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Chronic | 2 2 2 2 3 2 3 2 2 3 2 2 3 3 2 2 2 3 2 2 1 | 42 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| |
| 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 39 2.1|
Hypertrophy | 2 2 2 2 2 2 2 2 2| 15 2.1|
Vacuolization Cytoplasmic | 2 2 2 2 2 3 2 1 | 17 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + M + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X X X X X X X X X X| 20 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 3 2 2| 13 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 2 3 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3| 50 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 2 2 2 2 2 2 2 2 2 3 2 3| 24 2.1|
Duct, Dilatation | 3 3 3 3 3 3 3 3| 19 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 3 3 | 3 3.0|
Follicle, Cyst | X X | 3 |
Periovarian Tissue, Cyst | X X | 9 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 4 2 | 7 3.0|
Cervix, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Hyperplasia | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 4 |
Hyperplasia, Lymphoid | | 1 4.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Sinus, Ectasia | 4 | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3| |
| 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Thymus | M M + + + + + + + + + M + + + + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Cystic | 2 2 3 3 3 2 3 3 2 3 2 3 3 2 3 2 3 2 3 3 2 3 2| 46 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 7 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
Nerve, Demyelination | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Lens, Cataract | 3 | 4 2.8|
Retina, Atrophy | 4 | 4 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nephropathy, Chronic | 2 1 2 1 2 2 1 2 1 1 2 1 1 1 4 1| 25 1.7|
Renal Tubule, Mineralization | | 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3|
| 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | M + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 2 X 2 1 3 2 2 2 2 2 3 1 2 2 1 1 2 2 2 2 2 2|
Degeneration, Cystic | 1 |
Eosinophilic Focus | 1 1 1 2 X 3 1 1 1 1 1 1 2 2|
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | 2 1 2 |
Vacuolization Cytoplasmic | 2 1 3 |
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 2 2 1 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
Degeneration, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
Hyperplasia | 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3|
| 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + |
C-Cell, Hyperplasia | 3 3 2 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + |
Hyperplasia | 2 |
Inflammation, Chronic Active | 3 2 2 3 2 2 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + |
Follicle, Cyst | |
Periovarian Tissue, Cyst | X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 4 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | M + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thymus | + + M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + |
Hyperplasia, Cystic | 2 3 2 |
__________________________________________________________________________|
Skin | + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Compression | |
Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | + |
Nerve, Demyelination | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3|
| 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Choroid, Hemorrhage | |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + |
Hydronephrosis | |
Nephropathy, Chronic | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + |
Mucosa, Hyperplasia, Papillary | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | 1 2 2 2 1 1 2 2 2 1 1 3 2 2 1 1 2 2 1 2 2| 44 1.8|
Degeneration, Cystic | 1 | 2 1.0|
Eosinophilic Focus | 2 2 2 1 1| 19 1.4|
Hepatodiaphragmatic Nodule | X X| 3 |
Inflammation, Chronic Active | 1 1 2 1 2 2 2 1 1 | 12 1.5|
Vacuolization Cytoplasmic | 3 4 3 | 6 2.7|
Bile Duct, Hyperplasia | 2 2 1 1 3 1 2 | 18 1.7|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 12 |
Acinus, Atrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 1 2 | 2 1.5|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 11 |
Degeneration, Chronic | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 10 |
Hyperplasia | 2 2 2 2 | 6 2.0|
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + | 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| 34 |
Pars Distalis, Cyst | X X X X X X X| 9 |
Pars Distalis, Hyperplasia | 2 2 3 3 3| 7 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 12 |
C-Cell, Hyperplasia | 2 1 3 3 2 2 | 11 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + | 15 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 2 2 2 4 2 2 | 13 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + | 23 |
Follicle, Cyst | X | 1 |
Periovarian Tissue, Cyst | X X X X X | 11 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + +| 17 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 4 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 16 |
Hyperplasia, Cystic | 3 3 2 3 3 3 3 | 10 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 11 |
Compression | X X X | 3 |
Hydrocephalus | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
Nerve, Demyelination | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + + + | 11 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Choroid, Hemorrhage | 3 | 1 3.0|
Lens, Cataract | 3 | 2 3.5|
Retina, Atrophy | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 11 |
Hydronephrosis | 3 | 1 3.0|
Nephropathy, Chronic | 2 2 2 1 2 | 7 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 11 |
Mucosa, Hyperplasia, Papillary | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3|
| 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
Diverticulum | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X 2 2 3 2 2 2 3 2 2 2 2 2 1 2 1 2 X 2 2|
Cytomegaly | 1 |
Eosinophilic Focus | X 1 1 3 X X X 2 3 1 1 1 X 1|
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | |
Hypertrophy | 2 3 1 2 2 1|
Inflammation, Chronic Active | 2 3 2 2 3 2 2 2 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 1 2 1 3 2 4 3 4 1 2|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 4 3 3 1 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + M + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | 3 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Degeneration, Chronic | 2 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
Hyperplasia | 2 |
Hypertrophy | 2 2 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3|
| 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + +|
C-Cell, Hyperplasia | 3 3 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + |
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 2 2 2 2 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + |
Periovarian Tissue, Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + |
Dilatation | 4 |
Fibrosis | |
Cervix, Cyst | X X |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + M + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + |
Hyperplasia, Cystic | 3 3 3 3 3 4 |
__________________________________________________________________________|
Skin | + + + + + + + |
Subcutaneous Tissue, Lip, Foreign | |
Body | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3|
| 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Lip, | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
Cranium, Fracture | X |
Femur, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Compression | X X |
Hemorrhage | |
Hydrocephalus | 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
__________________________________________________________________________|
Nose | + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Nephropathy, Chronic | 2 2 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8| |
| 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + +| 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + +| 12 |
Diverticulum | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + +| 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 2 2 2 1 2 X 2 2 2 2 2 2 2 2 2 2 1 2 2 | 40 1.9|
Cytomegaly | | 1 1.0|
Eosinophilic Focus | 1 1 3 3 1 | 19 1.6|
Hepatodiaphragmatic Nodule | X | 2 |
Hyperplasia, Focal | 1 | 1 1.0|
Hypertrophy | 1 1 2 | 9 1.7|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 1 | 19 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 2 2 2 4 3 4 | 18 2.4|
Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 2 4 2 2 2 4 2 2 2 2 2 | 34 2.2|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + +| 11 |
Acinus, Atrophy | 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + +| 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | 3 2 2 | 5 2.4|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + +| 12 |
Degeneration, Chronic | 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8| |
| 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + +| 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + +| 12 |
Hyperplasia | 2 | 2 2.0|
Hypertrophy | 2 | 3 2.0|
Necrosis | 3 | 2 3.0|
Vacuolization Cytoplasmic | | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + +| 12 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + +| 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + +| 11 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + +| 27 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 3 3 2 3 | 6 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + +| 15 |
C-Cell, Hyperplasia | 3 2 3 3 2| 12 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + +| 12 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 2 2 2 2| 10 2.0|
Duct, Dilatation | 3 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + +| 19 |
Periovarian Tissue, Cyst | X X X X | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + +| 18 |
Dilatation | | 1 4.0|
Fibrosis | 3 | 1 3.0|
Cervix, Cyst | | 2 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 3 | 4 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + +| 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + +| 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| |
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8| |
| 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + +| 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + +| 13 |
Hyperplasia, Cystic | 3 3 3 2| 10 3.0|
__________________________________________________________________________|____________|
Skin | + + + + +| 12 |
Subcutaneous Tissue, Lip, Foreign | | |
Body | 4| 1 4.0|
Subcutaneous Tissue, Lip, | | |
Inflammation, Chronic Active | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + +| 11 |
Cranium, Fracture | | 1 |
Femur, Hyperostosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + +| 11 |
Compression | X | 3 |
Hemorrhage | 1 | 1 1.0|
Hydrocephalus | 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + +| 11 |
__________________________________________________________________________|____________|
Nose | + + + +| 11 |
__________________________________________________________________________|____________|
Trachea | + + + +| 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | 3 | 1 3.0|
Retina, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + +| 11 |
Nephropathy, Chronic | 3 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + +| 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3|
| 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 3 2 2 2 2 2 3 2 2 2 2 3 2 2 2 2|
Eosinophilic Focus | 3 2 2 2 2 4 3 2 3 3 4 2 3 4 4 4 4 3 1 3 3 3 2|
Hypertrophy | 1 1 1 2 1 2 2 2 1 1 2 2 2 2 2 2 |
Inflammation, Chronic, Multifocal | 1 1 2 2 2 2 2 2|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 3 |
Necrosis | 1 |
Vacuolization Cytoplasmic | 4 3 2 3 2 2 3 3 2 3 2 3 4 4 2 2 3 3 2 3 4 2 3 2 |
Bile Duct, Hyperplasia | 4 2 2 2 2 3 2 2 3 3 2 2 2 2 3 2|
Oval Cell, Hyperplasia | 3 1 1 2 2 2 |
Subserosa, Congestion, Multifocal | 2 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + M + |
Ectopic Liver | X |
Acinus, Atrophy | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 |
Inflammation, Chronic Active | |
Ulcer | 2 |
Submucosa, Foreign Body | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Mineralization | 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Degeneration, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3|
| 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + A + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + A + + |
Hyperplasia | 2 |
Hypertrophy | |
Necrosis | 2 |
Vacuolization Cytoplasmic | 3 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + A + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + +|
Hyperplasia | |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + |
C-Cell, Hyperplasia | 2 3 2 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + |
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 |
Duct, Dilatation | 2 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + +|
Periovarian Tissue, Cyst | X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + |
Dilatation | 3 |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + A + |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + I M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 3 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3|
| 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + A + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + |
Compression | X X |
Hydrocephalus | 2 3 |
__________________________________________________________________________|
Spinal Cord | + |
Nerve, Demyelination | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
Interstitium, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Nose | + + + + + A + |
Mucosa, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Nephropathy, Chronic | 2 2 3 2 1 2 |
Cortex, Infarct | |
Renal Tubule, Mineralization | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3| |
| 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 13 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + M + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 4 2 | 4 2.3|
Basophilic Focus | 4 3 2 2 X 2 3 2 2 2 1 2 2 2 2 2 2 3 2 2| 37 2.2|
Eosinophilic Focus | 4 3 4 2 2 3 2 3 2 3 1 2 4 X 3 3 1 3 4 2 3 3 2 4| 47 2.8|
Hypertrophy | 2 3 1 2 1 2 2 1 2 1 2 1 1 1 1 1| 32 1.6|
Inflammation, Chronic, Multifocal | 2 1 2 2 2 2 1 2 2 2 2 1 2| 21 1.8|
Inflammation, Chronic Active | 2 1 2 2 2 | 13 2.0|
Necrosis | 2 2 2 1 | 5 1.6|
Vacuolization Cytoplasmic | 4 3 2 3 3 4 2 2 3 2 2 3 3 3 3 3 2 4 2 3 3 2 2| 47 2.7|
Bile Duct, Hyperplasia | 3 2 2 2 3 2 2 2 2 2 2 3 3 3 2 2 3 2 2 3 2 2 2| 39 2.3|
Oval Cell, Hyperplasia | 2 2 2 2 1 1| 12 1.8|
Subserosa, Congestion, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 13 |
Ectopic Liver | | 1 |
Acinus, Atrophy | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 | 3 2.7|
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | | 1 2.0|
Submucosa, Foreign Body | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 1 2.0|
Mineralization | 2 2 | 3 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3| |
| 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 14 |
Degeneration, Chronic | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 14 |
Hyperplasia | 3 2 | 3 2.3|
Hypertrophy | 2 | 1 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 2 3 2 | 6 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 13 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 29 |
Hyperplasia | 2 | 1 2.0|
Pars Distalis, Cyst | X X X | 5 |
Pars Distalis, Hyperplasia | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 14 |
C-Cell, Hyperplasia | 3 3 3 3 3 2 | 12 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 16 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 3 2 2 2 2 | 6 2.2|
Duct, Dilatation | 3 3 3 2 2 | 8 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + +| 22 |
Periovarian Tissue, Cyst | X X X X X X | 9 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 18 |
Dilatation | | 1 3.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3| |
| 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + + + +| 21 |
Hyperplasia, Cystic | 3 3 2 3 2 3 | 13 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 14 |
Compression | X | 3 |
Hydrocephalus | 3 | 3 2.7|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Nerve, Demyelination | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 14 |
Interstitium, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 13 |
Mucosa, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
Lens, Cataract | 3 3 3 | 4 3.3|
Retina, Atrophy | 4 4 4 | 4 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 14 |
Nephropathy, Chronic | 1 2 1 3 1 | 11 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3| |
| 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cortex, Infarct | 3 | 1 3.0|
Renal Tubule, Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3|
| 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + A + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + A + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 2 3 2 2 2 2 1 2 3 1 2 2 1 2 2 1 3|
Degeneration, Cystic | 4 2 |
Eosinophilic Focus | 4 3 4 3 3 4 2 3 2 2 2 2 4 3 2 2 3 3 4 2 4|
Eosinophilic Focus, Multiple | X |
Hypertrophy | 1 2 2 2 2 1 1 1 1 1 2 2 2 1 1 1 1 1|
Inflammation, Chronic, Multifocal | 1 1 1 1|
Inflammation, Chronic Active | 2 4 2 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 3 4 3 2 3 3 2 3 3 4 2 3 2 2 2 3 4 3 3|
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 2 2 3 2 2 2 3 2 2 3 1 2 2 2 2 2 2|
Oval Cell, Hyperplasia | 1 3 2 3 1 2 1 |
Periportal, Infiltration Cellular, | |
Lymphocyte | 4 1 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + A + + + A + + |
Acinus, Atrophy | 2 2 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Degeneration, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + A + + + A + + |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3|
| 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + A + + + A + + |
Cyst | X |
Hyperplasia | 2 |
Necrosis | |
Vacuolization Cytoplasmic | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + A + + + A + + |
__________________________________________________________________________|
Islets, Pancreatic | + A + + + A + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 3 2 |
__________________________________________________________________________|
Thyroid Gland | + A + + + + + + |
Atrophy | |
Infiltration Cellular, Lymphocyte | 2 |
C-Cell, Hyperplasia | 3 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + A + + + + + + |
Inflammation, Chronic Active | 2 2 |
Duct, Dilatation | 3 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
Necrosis | |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 4 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + A + + + A + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Capsule, Hemorrhage | 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3|
| 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + |
Hyperplasia, Cystic | 3 3 3 3 3 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
Femur, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + A + + + + + + |
Compression | X X |
Hydrocephalus | 2 2 |
__________________________________________________________________________|
Spinal Cord | |
Nerve, Demyelination | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
__________________________________________________________________________|
Nose | + A + + + + + + |
__________________________________________________________________________|
Trachea | + A + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Nephropathy, Chronic | 2 1 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| |
| 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + +| 11 |
__________________________________________________________________________|____________|
Intestine Large | + + +| 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + +| 11 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + +| 9 |
__________________________________________________________________________|____________|
Intestine Small | + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + +| 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + +| 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | 2 1 2 2 2 2 2 3 2 2 2 2 2 4 2 2 X 2 | 36 2.0|
Degeneration, Cystic | | 2 3.0|
Eosinophilic Focus | 4 2 2 4 4 2 3 3 3 X 2 3 3 4 3 3 4 4 4 4 3 3 3 3| 45 3.0|
Eosinophilic Focus, Multiple | | 1 |
Hypertrophy | 3 2 1 3 3 2 1 1 1 1 1 1 2 2 1 1 1 1 2 2 2| 39 1.5|
Inflammation, Chronic, Multifocal | 1 1 1 1 | 8 1.0|
Inflammation, Chronic Active | 2 2 2 2 2 1 2 2 | 12 2.1|
Necrosis | 1 1 1 1 | 5 1.2|
Vacuolization Cytoplasmic | 4 2 3 2 2 3 2 2 2 3 2 3 3 3 2 3 3 3 2 3 2 3 2 4| 43 2.7|
Bile Duct, Cyst | X | 1 |
Bile Duct, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2 2| 38 2.0|
Oval Cell, Hyperplasia | 3 1 1 2 3 2 2 1 2 1 1 2| 19 1.8|
Periportal, Infiltration Cellular, | | |
Lymphocyte | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + +| 9 |
Acinus, Atrophy | 2 | 4 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + +| 11 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| |
| 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + +| 11 |
Degeneration, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + +| 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + +| 9 |
Cyst | | 1 |
Hyperplasia | | 1 2.0|
Necrosis | 3 | 1 3.0|
Vacuolization Cytoplasmic | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + +| 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + +| 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M +| 9 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + +| 28 |
Pars Distalis, Cyst | X X X X X| 8 |
Pars Distalis, Hyperplasia | 3 3 3 3 | 6 2.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + +| 10 |
Atrophy | 3| 1 3.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
C-Cell, Hyperplasia | 3 3 3| 10 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + +| 10 |
Inflammation, Chronic Active | 2 | 3 2.0|
Duct, Dilatation | | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + +| 14 |
Periovarian Tissue, Cyst | X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + +| 21 |
Hemorrhage | 3 4| 2 3.5|
Inflammation, Acute | 4| 1 4.0|
Necrosis | 4| 1 4.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 2 2 | 7 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + +| 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| |
| 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + +| 12 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Lymphoid | | 1 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Capsule, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + +| 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + +| 16 |
Hyperplasia, Cystic | 3 3 3| 10 2.9|
__________________________________________________________________________|____________|
Skin | + + +| 11 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + +| 11 |
Femur, Hyperostosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + +| 10 |
Compression | X | 3 |
Hydrocephalus | 3 | 3 2.3|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Nerve, Demyelination | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 9 |
__________________________________________________________________________|____________|
Nose | + + +| 10 |
__________________________________________________________________________|____________|
Trachea | + + +| 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 3 |
Lens, Cataract | 3 4 4 | 3 3.7|
Retina, Atrophy | 4 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + +| 11 |
Nephropathy, Chronic | 1 2 1| 8 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| |
| 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + +| 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + +|
__________________________________________________________________________|
Intestine Large | + M + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + M + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 2 1 3 2 3 2 3 2 X |
Degeneration, Cystic | 2 |
Eosinophilic Focus | 4 4 4 2 2 4 4 4 3 3 4 4 4 4 2 4 4 4 4 4 4 2|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Hypertrophy | 2 1 2 1 1 3 1 1 1 2 2 2 1 1 2 2 2 1 1 1 2|
Inflammation, Chronic, Multifocal | 1 2 1 |
Inflammation, Chronic Active | 2 2 2 2 2 |
Necrosis | 3 2 3 1 |
Vacuolization Cytoplasmic | 3 3 3 2 2 2 2 2 2 3 3 3 3 2 2 3 2 2 2 2 2 3 2 4|
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 2 3 2 2 3 2 2 2 1 2 2 3 2 3 1 2 2 2 2 2 2 2 2|
Oval Cell, Hyperplasia | 2 1 2 2 1 2 2 2 2 2 1 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 3 2 1 3 2 2 2 |
Ulcer | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + +|
Degeneration, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + +|
Hyperplasia | |
Hypertrophy, Focal | |
Necrosis | 4 |
Vacuolization Cytoplasmic | 3 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + +|
C-Cell, Hyperplasia | 3 2 2 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 2|
Duct, Dilatation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + +|
Follicle, Cyst | X|
Periovarian Tissue, Cyst | X X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + +|
Cervix, Cyst | X |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + +|
Mandibular, Necrosis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + I +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + +|
Hyperplasia, Cystic | 3 2 3|
__________________________________________________________________________|
Skin | + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + +|
Femur, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
Compression | |
Hydrocephalus | |
__________________________________________________________________________|
Spinal Cord | |
Nerve, Demyelination | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + +|
Interstitium, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Nose | + + + + +|
__________________________________________________________________________|
Trachea | + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 3 4 3 |
Retina, Atrophy | 4 4 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + +|
Nephropathy, Chronic | 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + +|
Calculus Micro Observation Only | |
Mucosa, Hyperplasia, Papillary | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3| |
| 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 12 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 2 2 1 2 2 2 2 2 1 2 3 | 23 2.0|
Degeneration, Cystic | 2 3 | 3 2.3|
Eosinophilic Focus | 4 2 4 4 4 4 4 4 3 3 4 3 3 4 2 4 4 3 4 3 4 3 4| 45 3.5|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 1 |
Hypertrophy | 3 2 2 2 2 3 3 2 2 2 2 1 2 2 3 2 1 1 1 | 40 1.8|
Inflammation, Chronic, Multifocal | 2 2 1 1 | 7 1.4|
Inflammation, Chronic Active | 2 2 2 | 8 2.0|
Necrosis | 2 | 5 2.2|
Vacuolization Cytoplasmic | 3 3 2 3 2 3 2 3 3 4 2 2 2 2 3 2 3 3 3 | 43 2.5|
Bile Duct, Cyst | 2 | 1 2.0|
Bile Duct, Hyperplasia | 3 2 2 2 2 3 2 2 2 2 3 2 3 2 3 2 2 1 3 2| 44 2.2|
Oval Cell, Hyperplasia | 2 1 3 2 2 1 1 1 2 1 2 3 3 2 1 1 2 2| 34 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Inflammation, Chronic Active | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 12 |
Acinus, Atrophy | 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 1 | 10 2.0|
Ulcer | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3| |
| 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 12 |
Degeneration, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 12 |
Hyperplasia | 2 3 | 2 2.5|
Hypertrophy, Focal | 4 | 1 4.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | 2 2 2 1 | 6 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + | 10 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 27 |
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 3 2 3 2 2 2 | 8 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 13 |
C-Cell, Hyperplasia | 3 2 3 2 3 2 3 | 12 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + +| 13 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic Active | 2 3 2 | 5 2.2|
Duct, Dilatation | 2 2 3| 4 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 20 |
Follicle, Cyst | | 1 |
Periovarian Tissue, Cyst | X | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + | 20 |
Cervix, Cyst | X X | 3 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 3 2 2 | 6 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | I + + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 12 |
Mandibular, Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3| |
| 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosis | 2 3 | 2 2.5|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 11 |
Hyperplasia, Cystic | 3 2 3 3 2 3 | 9 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 12 |
Femur, Hyperostosis | X | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 12 |
Compression | X | 1 |
Hydrocephalus | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Nerve, Demyelination | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 11 |
Interstitium, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Lens, Cataract | 3 3 | 5 3.2|
Retina, Atrophy | 4 4 | 5 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 12 |
Nephropathy, Chronic | 1 1 2 2 2 | 8 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7| |
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3| |
| 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Calculus Micro Observation Only | X | 1 |
Mucosa, Hyperplasia, Papillary | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5|
| 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 2 2 2 2 2 3 2 |
Eosinophilic Focus | 4 4 4 4 2 4 4 4 4 4 4 2 4 4 4 4 3 4 4 4 4 4 4 |
Hypertrophy | 3 3 2 2 3 2 3 3 3 3|
Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Chronic Active | 2 2 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 3 2 3 2 2 2 2 2 3 3 2 3 4 3 2 1 3 3 3 3 3 3 3 3 4|
Bile Duct, Cyst | 2 |
Bile Duct, Fibrosis | 2 |
Bile Duct, Hyperplasia | 3 2 3 2 2 2 2 3 2 2 3 2 2 2 3 2 3 2 3 3 2 3 3 2 2|
Bile Duct, Metaplasia | 1 |
Oval Cell, Hyperplasia | 2 2 3 1 2 3 2 2 2 3 3 3 3 3 4 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 1 3 4 2 2 2 3 2 2 3 2 3 4 2 2 |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Cytomegaly, Focal | 2 |
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 2 2 2 2 2 2 2 2 2 2 1 |
Myocardium, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5|
| 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 2 3 2 4 3 2 3 3 |
Hypertrophy | 2 2 2 3 2 2 2 2|
Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + M M + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 2 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
C-Cell, Hyperplasia | 2 2 2 2 3 2 2 3 3 2 3 3 2 2 3 2 3 2 2 2 2 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 |
Duct, Dilatation | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Periovarian Tissue, Cyst | X X X|
Rete Ovarii, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 3 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Angiectasis | 3 |
Mediastinal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Thoracic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + M + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5|
| 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 3 3 3 2 3 3 2 3 3 2 3 3 2 3 3 4 3 2 3 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Granulomatous | |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 1 2 1 2 2 2 1 2 1 1 2 1 1 1 1 2 2 1 2 |
Renal Tubule, Mineralization | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7| |
| 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + M + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + A + + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X X | 6 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 3 | 11 2.1|
Eosinophilic Focus | 4 2 4 4 4 4 4 4 4 4 4 4 4 4 1 4 4 4 2 3 4 3 4 3 4| 48 3.7|
Hypertrophy | 4 2 3 3 4 2 3 | 17 2.8|
Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 | 31 2.0|
Inflammation, Chronic Active | 2 | 3 2.0|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | 3 3 2 2 3 3 2 2 3 3 4 2 3 2 2 2 2 3 3 2 3 3 3 2 3| 50 2.6|
Bile Duct, Cyst | 3 | 2 2.5|
Bile Duct, Fibrosis | 2 2 | 3 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 3 3 3 3 3 2 3 2 2 2 2 2 3 3 2 2 3 3 2 2 2| 51 2.4|
Bile Duct, Metaplasia | | 1 1.0|
Oval Cell, Hyperplasia | 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 4 3 3 3 4 3 3 3| 42 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 2 1 1 2 4 4 2 2 2 2 2 | 29 2.3|
Perivascular, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cytomegaly, Focal | | 1 2.0|
Acinus, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Chronic | 2 2 1 3 2 2 2 2 | 21 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7| |
| 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Myocardium, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 3 2 | 19 2.4|
Hypertrophy | 2 | 9 2.1|
Vacuolization Cytoplasmic | 2 3 1 2 2 2 3 2 3 | 18 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 46 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 3 3 2 3 2 2 2 | 13 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 2 2 3 2 2 2 2 3 2 2 3 2 2 2 2 2 2 3 2 2 2| 43 2.3|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + M + + + + + +| 47 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 3 | 22 2.0|
Duct, Dilatation | 3 3 3 3 3 3 3 3 3 3 3 | 26 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicle, Cyst | X | 1 |
Periovarian Tissue, Cyst | X X X X X X X X| 11 |
Rete Ovarii, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 3 2 3 2 3 | 12 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7| |
| 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mandibular, Angiectasis | | 1 3.0|
Mediastinal, Angiectasis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Thoracic | + + | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + I + M + M + + + + + + M + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Hyperplasia, Cystic | 3 2 3 3 3 2 3 3 3 3 3 3 3 3 2 3 3 3 2 3 4 3 2| 47 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Femur, Hyperostosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 3 1 | 2 2.0|
Interstitium, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mucosa, Inflammation, Chronic Active | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 1 3.0|
Retina, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7| |
| 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 1 2 1 2 1 3 2 2 1 1 1 2 2 2 1| 37 1.6|
Renal Tubule, Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3|
| 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 4 2 3 X 3 2 2 |
Cytomegaly | |
Eosinophilic Focus | 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 2 4 4|
Hypertrophy | 2 3 2 |
Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 |
Inflammation, Chronic Active | 2 |
Inflammation, Multifocal | |
Necrosis | 2 |
Thrombosis | X |
Vacuolization Cytoplasmic | 2 3 4 4 3 3 2 2 2 2 2 3 2 3 3 3 3 2 2 2|
Bile Duct, Cyst | X X |
Bile Duct, Fibrosis | 2 2 3 2 2 2 3 3 |
Bile Duct, Hyperplasia | 3 2 2 2 2 3 4 |
Oval Cell, Hyperplasia | 3 3 4 4 3 3 3 3 3 4 3 3 3 4 3 3 3 3 3 3 3 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change, Multiple | |
Acinus, Atrophy | 2 3 3 1 3 1 3 3 2 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Inflammation, Chronic Active | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3|
| 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 2 2 2 2 3 2 3 2 2 3|
Hypertrophy | 2 2 1 3 |
Vacuolization Cytoplasmic | 2 2 2 2 2 3 3 2 2 2 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 3 2 3 2 3 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 3 3 3 3 2 2 2 2 3 2 3 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 |
Duct, Dilatation | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +|
Periovarian Tissue, Cyst | X X X X X|
__________________________________________________________________________|
Oviduct | |
Dilatation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Cervix, Cyst | X |
Cervix, Mucosa, Hyperplasia, Squamous| 2|
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 3 3 3|
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + I + + + + + I + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + M + + + + + +|
Mandibular, Infiltration Cellular, | |
Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thymus | + + + + + M + + M + + + + + + M + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3|
| 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 3 2 3 2 2 2 3 3 3 1 3 2 2 2 3 3 3 3 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 2 2 2 1 1 1 1 2 2 1 1 1 1 2 2 1 1 1|
Renal Tubule, Inflammation, Acute, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3| |
| 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 3 2 2 2 | 13 2.6|
Cytomegaly | 3 | 1 3.0|
Eosinophilic Focus | 4 4 4 4 4 4 4 3 2 4 4 4 4 3 4 4 3 4 4 4 4 4 4| 47 3.8|
Hypertrophy | 3 2 3 | 6 2.5|
Inflammation, Chronic, Multifocal | 2 2 2 2 2 1 2 2 2 2| 22 2.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Inflammation, Multifocal | 2 | 1 2.0|
Necrosis | 3 2 | 3 2.3|
Thrombosis | | 1 |
Vacuolization Cytoplasmic | 2 3 2 3 2 4 3 3 3 2 2 4 2 3 3 4 3 3 2 3 | 40 2.7|
Bile Duct, Cyst | X X X | 5 |
Bile Duct, Fibrosis | 3 3 3 3 2 3 2 3 4 3 3 | 19 2.7|
Bile Duct, Hyperplasia | 2 3 3 2 2 2 2 2 | 15 2.4|
Oval Cell, Hyperplasia | 3 3 4 3 3 3 3 3 1 3 3 3 3 3 2 3 4 4 3 3| 44 3.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change, Multiple | 2 | 1 2.0|
Acinus, Atrophy | 2 1 4 2 3 3 3 3 1 2 4 2 3 2 | 25 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 2 | 5 2.0|
Inflammation, Chronic Active | 3 2 | 3 2.3|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3| |
| 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Chronic | 2 2 2 2 2 2 | 11 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 2 |
Hyperplasia | 2 2 3 3 2 3 3 2 2 3| 21 2.4|
Hypertrophy | 2 2 3 2 2| 9 2.1|
Vacuolization Cytoplasmic | 2 3 2 2 2 3 1 2 3 2 2 2 | 25 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 3 2 2 2 2 | 13 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 2 2 3 2 2 2 2 2 3 2 2 2 3 2 3 3 3 3 3 2 3 3 2 2| 47 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + + + + + + M + + + + + + + + + M + + +| 46 |
Inflammation, Chronic Active | 2 2 2 2 2 4 | 13 2.2|
Duct, Dilatation | 3 3 3 3 3 3 3 3 3 | 23 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Periovarian Tissue, Cyst | X X X X | 9 |
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 | 1 3.0|
Cervix, Cyst | X | 2 |
Cervix, Mucosa, Hyperplasia, Squamous| | 1 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | 2 2 2 2 2 2 3 | 11 2.4|
__________________________________________________________________________|____________|
Vagina | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3| |
| 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Mandibular, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Thymus | + M M + + M + + M + + + + + + + + + + + + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + M + + + + +| 48 |
Hyperplasia, Cystic | 2 3 3 2 2 2 3 2 3 3 3 3 3 2 3 4 3 2 2 2 2| 43 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Metaplasia, Focal, Osseous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Inflammation, Chronic Active | 2| 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 5 |
Lens, Cataract | 3 3 3 | 4 3.0|
Retina, Atrophy | 4 4 4 | 4 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 2 2 2 1 2 3 1 2 2 2 2 2 1 2 1 1 1 1 1 2 1 | 42 1.5|
Renal Tubule, Inflammation, Acute, | | |
Multifocal | 3| 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| |
DAY ON TEST | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3| |
| 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4| 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3|
| 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 2 2 3 2 1 3 3 2 1 1 4 2|
Clear Cell Focus | 1 |
Degeneration, Cystic | 2 2 2 2 2 2 2 2 2 2|
Eosinophilic Focus | 2 1 1 3 1 1 2 1 1|
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 3 3 |
Inflammation, Chronic Active | 3 |
Vacuolization Cytoplasmic | 4 3 3 3 |
Bile Duct, Hyperplasia | 4 2 3 4 3 2 3 2 3 3 4 3 4 2 3 2 4 2 3 2 3 2 3 2 3|
Centrilobular, Degeneration | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 2 2 2 2 2 2 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Foreign Body | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Chronic | 3 3 3 3 3 2 2 2 2 2 2 3 3 3 3 2 2 2 3 3 2 2 3 3 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2|
Hypertrophy | 2 2 2 2 2 |
Vacuolization Cytoplasmic | 4 2 3 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 2|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3|
| 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + + + + + + + + + + + M + M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Follicular Cell, Hypertrophy | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation, Chronic Active | 2 2 3 2 3 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2|
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 3 4 |
Metaplasia, Squamous | 2 2 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 1 |
Seminiferous Tubule, Atrophy | 4 |
Seminiferous Tubule, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Reticulum Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Subcutaneous Tissue, Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3|
| 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Nerve, Demyelination | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active | 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 4 |
Nephropathy, Chronic | 3 2 3 4 2 3 3 2 3 3 3 2 3 2 2 2 3 4 4 4 3 2 3 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mucosa, Ulcer | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7| |
| 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 X 1 1 2 1 2 2 1 1 1 1 1 1 | 27 1.7|
Clear Cell Focus | | 1 1.0|
Degeneration, Cystic | 2 2 2 2 2 2 3 2 | 18 2.1|
Eosinophilic Focus | 1 1 1 1 1 1 1 1 1 | 18 1.2|
Hyperplasia, Focal | 2 | 2 2.0|
Hyperplasia, Multifocal | | 2 3.0|
Inflammation, Chronic Active | | 1 3.0|
Vacuolization Cytoplasmic | 3 | 5 3.2|
Bile Duct, Hyperplasia | 2 3 4 3 4 3 3 2 2 3 3 2 2 2 2 2 3 3 3 3 3 2 4 | 48 2.8|
Centrilobular, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Acinus, Atrophy | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 | 23 2.0|
Acinus, Hyperplasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 |
Foreign Body | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Chronic | 3 2 2 3 3 2 2 2 1 2 3 2 3 3 3 3 2 2 2 1 2 3 3 3 3| 50 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7| |
| 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 2 2 2 2 2 2 2 | 19 2.1|
Hypertrophy | 2 2 3 | 8 2.1|
Vacuolization Cytoplasmic | 1 2 1 2 2 | 11 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 2 2 2 3 2 2 | 13 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M M + + + + + + +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 3 2 3 2 3 2 | 9 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| 48 2.0|
Follicular Cell, Hypertrophy | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 3 2.0|
Inflammation, Chronic Active | 2 2 2 2 4 2 3 4 3 2 2 2 2 2 2 2 3| 37 2.3|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 2 2 2 3 2 | 11 2.5|
Metaplasia, Squamous | 2 2 2 2 2 2 | 11 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 2 2 | 8 1.9|
Seminiferous Tubule, Atrophy | 3 3 | 3 3.3|
Seminiferous Tubule, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Femoral, Hyperplasia, Reticulum Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandibular, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | +| 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7| |
| 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 2| 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + | 39 |
Hyperplasia, Cystic | 2 3 2 2 2 2 2 2 2 3 2 2 3 3 2 3 3 | 38 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 4 | 1 4.0|
Subcutaneous Tissue, Fibrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X | 3 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
Nerve, Demyelination | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia | 3 | 1 3.0|
Interstitium, Inflammation, Chronic | | |
Active | 3 | 3 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Inflammation, Chronic Active | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7| |
| 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 2 1 2 3 2 2 2 2 2 2 3 2 2 1 4 3 3 3 2 2 2 2 2 3 2| 50 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 4 | 1 4.0|
Mucosa, Ulcer | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|
| 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + |
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
Dilatation | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 1 1 1 1 2 1 2 2 1 2 1 1|
Clear Cell Focus | 2 |
Degeneration, Cystic | 2 2 2 2 2 |
Eosinophilic Focus | 4 2 2 2 2 2 X 2 2 2 2 2 3 2 2|
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 3 |
Hypertrophy | 1 1 1 |
Infarct | 4 |
Inflammation, Chronic | 2 |
Inflammation, Chronic, Multifocal | 2 |
Necrosis | |
Vacuolization Cytoplasmic | 1 2 3 2 1 2 1 2 2 2 4 2 2 |
Bile Duct, Hyperplasia | 3 2 2 3 4 2 3 3 3 2 3 3 4 3 2 2 3 3 4 3 2 4 3|
Centrilobular, Necrosis | |
Oval Cell, Hyperplasia | 1 2 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
Acinus, Atrophy | 3 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|
| 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + |
Degeneration, Chronic | 2 3 2 2 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + |
Hyperplasia | 2 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | 4 2 3 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 |
Pars Intermedia, Hyperplasia, | |
Glandular | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + |
C-Cell, Hyperplasia | 4 3 3 2 2 3 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + |
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 2 2 3 3 2 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + |
Inflammation, Chronic Active | 2 1 2 |
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 |
Seminiferous Tubule, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Mediastinal, Hyperplasia, Macrophage | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|
| 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Lymph Node, Thoracic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 4 |
Capsule, Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + M + + I M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Hyperplasia, Cystic | 3 2 2 2 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
Face, Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
Gliosis | 2 |
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage | |
Nerve, Demyelination | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active | 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + |
Mucosa, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + |
Hydronephrosis | 3 |
Nephropathy, Chronic | 4 2 4 2 2 2 2 3 1 1 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|
| 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cortex, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1| |
| 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A +| 20 |
Dilatation | 4| 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + +| 21 |
Dilatation | 4| 1 4.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A +| 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A +| 20 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 | 4 1.3|
Basophilic Focus | 1 2 1 1 1 1 | 19 1.3|
Clear Cell Focus | | 1 2.0|
Degeneration, Cystic | 2 2 2 2 2 2 3 | 12 2.1|
Eosinophilic Focus | 2 1 1 1 3 2 1 2 X 2 2 1 2 2| 29 2.0|
Hepatodiaphragmatic Nodule | X X | 4 |
Hyperplasia, Focal | | 1 3.0|
Hypertrophy | | 3 1.0|
Infarct | | 1 4.0|
Inflammation, Chronic | 1 2 2 | 4 1.8|
Inflammation, Chronic, Multifocal | | 1 2.0|
Necrosis | 2 2 | 2 2.0|
Vacuolization Cytoplasmic | 2 1 2 2 2 | 18 1.9|
Bile Duct, Hyperplasia | 3 3 2 3 4 4 4 3 3 2 3 4 3 2 2 3 3 2 3 2 3 3| 45 2.9|
Centrilobular, Necrosis | 3 | 1 3.0|
Oval Cell, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + +| 21 |
Acinus, Atrophy | 2 2 1 1 | 7 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 4 2 | 4 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1| |
| 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + +| 21 |
Degeneration, Chronic | 3 2 2 2 2 3 3| 12 2.3|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + +| 22 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + +| 21 |
Hyperplasia | 2 | 4 2.0|
Hypertrophy | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 2 2 1 2 | 10 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + +| 22 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + +| 27 |
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 3 2 3 | 5 2.4|
Pars Intermedia, Hyperplasia, | | |
Glandular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + A + +| 23 |
C-Cell, Hyperplasia | 2 3 3 3 2 2 3 3 3 2 3 3| 20 2.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | +| 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + +| 20 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + +| 25 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 2 3 2 2 2| 15 2.2|
Duct, Dilatation | 3 4| 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + +| 21 |
Inflammation, Chronic Active | 3 | 4 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1| |
| 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Dilatation | 4 | 1 4.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Interstitial Cell, Hyperplasia | 3 | 3 2.3|
Seminiferous Tubule, Atrophy | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + +| 21 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 23 |
Mediastinal, Hyperplasia, Macrophage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Thoracic | + | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3| 2 2.5|
Hematopoietic Cell Proliferation | 4 | 2 4.0|
Capsule, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + +| 17 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 14 |
Hyperplasia, Cystic | 2 2 3 2 2 3 3 | 14 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + +| 26 |
Face, Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + +| 21 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + +| 21 |
Gliosis | | 1 2.0|
Hemorrhage | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Hemorrhage | 3 | 1 3.0|
Nerve, Demyelination | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + +| 21 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1| |
| 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-0 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Interstitium, Inflammation, Chronic | | |
Active | | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + +| 21 |
Mucosa, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + +| 21 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 3.0|
Retina, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + +| 24 |
Hydronephrosis | 3 | 2 3.0|
Nephropathy, Chronic | 1 3 3 2 3 2 3 3 2 4 2 4 3| 23 2.5|
Cortex, Cyst | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + M + +| 20 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3|
| 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Basophilic Focus | 2 1 1 1 1 1 2 3 2 2 2 2 2 1 1 1 1 1 1 1|
Clear Cell Focus | X |
Congestion | 3 |
Degeneration, Cystic | 2 2 4 2 2 2 2 |
Eosinophilic Focus | 1 1 1 2 3 1 4 2 4 2 2 2 4 2 1 2 3 2 2 2 2|
Hepatodiaphragmatic Nodule | |
Hypertrophy | 2 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 1 1 |
Inflammation, Chronic, Multifocal | 2 1 1 2 2 2 |
Inflammation, Chronic Active | |
Necrosis | 1 2 2 |
Vacuolization Cytoplasmic | 3 1 2 2 3 2 3 2 3 2 2 2 2 3 2 3 1 2 3 4 2 2 2|
Bile Duct, Hyperplasia | 1 3 3 2 3 3 4 2 4 2 4 3 2 3 4 2 2 2 4 2 3 3 2 3 3|
Oval Cell, Hyperplasia | 2 3 2 |
Portal Vein, Thrombosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + |
Fibrosis | 4 |
Inflammation, Chronic Active | 4 |
Acinus, Atrophy | 1 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
Degeneration, Chronic | 3 2 3 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3|
| 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
Hyperplasia | 2 2 2 |
Necrosis | 4 |
Vacuolization Cytoplasmic | 3 3 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + |
C-Cell, Hyperplasia | 2 3 2 2 3 3 |
Follicle, Cyst | X |
Follicular Cell, Hypertrophy | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + |
Inflammation, Chronic Active | 2 2 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 3 2 3|
Seminiferous Tubule, Mineralization | 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
Femoral, Atrophy | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Hemorrhage | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | M + + + + + |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3|
| 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Chronic Active | 4 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
Hyperplasia, Cystic | 2 3 3 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Compression | X |
Hydrocephalus | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + |
__________________________________________________________________________|
Nose | + + + + + + |
Mucosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + |
Nephropathy, Chronic | 4 2 2 3 4 2 4 2 |
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3| |
| 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 16 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Basophilic Focus | 2 2 2 1 2 1 2 1 1 X 1 1 1 2 1 1| 36 1.4|
Clear Cell Focus | | 1 |
Congestion | | 1 3.0|
Degeneration, Cystic | 2 2 2 2 2 | 12 2.2|
Eosinophilic Focus | 1 4 3 2 2 1 2 1 3 2 1 3 2 2 3 2 2 2 2| 40 2.1|
Hepatodiaphragmatic Nodule | X | 1 |
Hypertrophy | 1 1 1 2 1 1 2 1 2 2 1 2 2 2 1 1| 34 1.3|
Inflammation, Chronic, Multifocal | 1 1 1 1 2 2 2| 13 1.5|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | 2 | 4 1.8|
Vacuolization Cytoplasmic | 2 2 2 3 2 3 2 2 1 3 4 2 2 2 4 2 3 2 3| 42 2.4|
Bile Duct, Hyperplasia | 3 4 4 4 3 3 4 3 2 2 2 3 3 4 3 2 3 3 3 3 2 2 3 4| 49 2.9|
Oval Cell, Hyperplasia | 3 | 4 2.5|
Portal Vein, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 16 |
Fibrosis | | 1 4.0|
Inflammation, Chronic Active | | 1 4.0|
Acinus, Atrophy | 2 2 1 2 3 | 8 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acanthosis | 3 4 | 3 3.3|
Inflammation, Chronic Active | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3| |
| 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Degeneration, Chronic | 3 3 3 3 2 | 9 2.7|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 15 |
Hyperplasia | 2 | 4 2.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | 2 3 2 | 7 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 16 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + | 22 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + +| 17 |
C-Cell, Hyperplasia | 3 3 3 3 3 3 3 3 3 2 | 16 2.8|
Follicle, Cyst | | 1 |
Follicular Cell, Hypertrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + | 20 |
Inflammation, Chronic Active | 2 2 2 2 3 2 2 2 3 2 | 14 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 16 |
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 3 |
Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | | 1 2.0|
Seminiferous Tubule, Atrophy | 3 2 | 5 2.6|
Seminiferous Tubule, Mineralization | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + M + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3| |
| 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Femoral, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 18 |
Mediastinal, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Depletion Lymphoid | 2 | 1 2.0|
Fibrosis | 2 2 2 4 | 6 2.3|
Hematopoietic Cell Proliferation | | 1 3.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 15 |
Inflammation, Chronic Active | | 1 4.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 14 |
Hyperplasia, Cystic | 3 3 3 3 2 2 | 12 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 16 |
Compression | X | 2 |
Hydrocephalus | 2 | 2 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 16 |
Mucosa, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 16 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
Lens, Cataract | 3 | 2 3.0|
Retina, Atrophy | 4 2 | 3 3.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3| |
| 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
3 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
1-1 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 20 |
Nephropathy, Chronic | 4 2 3 3 3 4 2 3 3 2 2 | 19 2.8|
Cortex, Cyst | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 17 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3|
| 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + |
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 1 1 1 2 2 2 1 1 1 2 1 1 2 1|
Degeneration, Cystic | 2 2 3 |
Eosinophilic Focus | 3 3 2 2 4 3 3 3 2 3 X 2 2 2 3 4 4 3 2 4 3|
Hypertrophy | 1 2 2 3 2 2 2 3 3 2 3 3 2 2 3|
Inflammation, Chronic, Multifocal | 2 2 2 2 |
Inflammation, Chronic Active | |
Necrosis | |
Vacuolization Cytoplasmic | 2 4 2 2 3 4 2 3 4 2 4 4 4 4 4|
Bile Duct, Hyperplasia | 2 3 2 2 4 4 3 4 3 4 2 3 2 3 4 4 3 2 4 3 3 3 3 2|
Oval Cell, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | |
Artery, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + |
Acinus, Atrophy | 1 2 1 3 1 3 2 2 |
Acinus, Cytomegaly, Focal | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 |
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | 4 3 3 |
Ulcer | 3 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
Degeneration, Chronic | 3 2 2 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3|
| 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + |
Hyperplasia | 2 2 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + |
Pars Distalis, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + |
C-Cell, Hyperplasia | 3 3 3 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + M |
Inflammation, Chronic Active | 3 2 2 3 2 2 2 4 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + |
Inflammation, Chronic Active | 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Thoracic | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Necrosis | 3 |
Thrombosis | |
__________________________________________________________________________|
Thymus | M + + + + + M + + M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + +|
Hyperplasia, Cystic | 3 2 3 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3|
| 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Acanthosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + |
Hemorrhage | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Lens, Cataract | 3 4 3 3 |
Retina, Atrophy | 4 4 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + |
Nephropathy, Chronic | 4 4 3 3 4 3 3 2 4 4 4 2 |
Cortex, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6| |
DAY ON TEST | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7| |
| 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + M + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + A + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + A + + + + + + + +| 26 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + +| 27 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + A + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + +| 28 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Basophilic Focus | 1 2 3 2 2 2 1 1 2 2 2 4| 28 1.6|
Degeneration, Cystic | 2 2 | 5 2.2|
Eosinophilic Focus | 2 2 3 3 2 2 2 3 3 2 2 4 2 3 2 4 2 2 3 3 3 4 3| 44 2.7|
Hypertrophy | 3 2 2 2 2 2 2 2 2 2 2 1| 27 2.2|
Inflammation, Chronic, Multifocal | 2 2| 6 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 3 3 2 3 2 2 1 1 2 2 2 2 | 28 2.7|
Bile Duct, Hyperplasia | 4 3 4 2 3 2 4 3 3 4 2 3 2 3 3 2 3 4 3 2 4 2 3 2| 48 3.0|
Oval Cell, Hyperplasia | 1 1 2 2 2 2 2 2 | 11 1.8|
__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Inflammation, Chronic Active | 2 | 1 2.0|
Artery, Inflammation, Chronic Active | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + +| 27 |
Acinus, Atrophy | 3 1 4 2 2 | 13 2.1|
Acinus, Cytomegaly, Focal | 2 | 1 2.0|
Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + M + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Acanthosis | 2 3 3 3 4| 7 3.0|
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic Active | 3 2 3| 6 3.0|
Ulcer | 2 2| 5 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6| |
DAY ON TEST | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7| |
| 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + M + + + + + + + +| 27 |
Degeneration, Chronic | 3 2 3 3 3 3 2 2 2 2 3 3 3 3 3| 23 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + A + + + + + + + +| 28 |
Hyperplasia | 2 2 2 2 2| 9 2.0|
Hypertrophy | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 2 2 3 2 2| 6 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +| 29 |
Hyperplasia | 2 2 3 2 2| 6 2.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + I + + + + + + + +| 32 |
Pars Distalis, Hyperplasia | 2 2 2 3 1 | 8 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + +| 28 |
C-Cell, Hyperplasia | 3 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 3 3| 28 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + +| 28 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +| 32 |
Inflammation, Chronic Active | 2 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2| 27 2.2|
Duct, Dilatation | 3 2| 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + +| 28 |
Inflammation, Chronic Active | 2 1 1 2 3| 8 1.9|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + M + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + +| 9 |
Angiectasis | 3| 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Thoracic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6| |
DAY ON TEST | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7| |
| 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Fibrosis | 4 2 2 | 4 2.5|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Necrosis | 2 | 2 2.5|
Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + I + + + M M + + + + + + +| 22 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + +| 23 |
Hyperplasia, Cystic | 3 3 2 3 3 2 3 2 3 2 3 3 4| 19 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + +| 31 |
Acanthosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 28 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 29 |
Hemorrhage | 2 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + M + + + + + + + +| 28 |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + + + +| 27 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + M + + + + + + + +| 27 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + +| 7 |
Lens, Cataract | 3 3 3| 7 3.1|
Retina, Atrophy | 4 4 4| 7 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + +| 32 |
Nephropathy, Chronic | 4 2 3 3 3 3 3 4 3 3 3 3 4 4 4 2 4 4 4 4| 32 3.3|
Cortex, Cyst | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + +| 27 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3|
| 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 3 1 1 |
Degeneration, Cystic | 2 2 2|
Eosinophilic Focus | 4 3 4 4 2 4 1 1 4 3 3 3 4 3 3 4 4 2 3 3 4|
Hypertrophy | 2 2 2 3 3 2 3 2 1 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Chronic, Multifocal | 2 2 2 |
Inflammation, Chronic Active | 1 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 2 3 1 1 2 3 4 2 2 2 3 2 3|
Bile Duct, Hyperplasia | 3 4 3 4 3 2 2 4 2 4 3 4 3 2 4 2 3 3 3 3 4 3 2 4|
Oval Cell, Hyperplasia | 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + |
Acinus, Atrophy | 2 3 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 3 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 3 3 3 |
Mineralization | 1 |
Ulcer | 2 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dysplasia | |
Inflammation, Chronic Active | 2 |
Mineralization | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3|
| 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Degeneration, Chronic | 2 2 2 2 2 3 2 3 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + |
Degeneration, Cystic | 2 |
Hyperplasia | 2 2 2 |
Necrosis | |
Vacuolization Cytoplasmic | 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 3 1 2 2 2 2 3 2 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 3 |
Duct, Dilatation | |
Duct, Hyperplasia, Squamous | 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
__________________________________________________________________________|
Lymph Node, Thoracic | + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7|
DAY ON TEST | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3|
| 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + M I |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + |
Hyperplasia, Cystic | 2 2 2 3 2 2 2 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + |
Compression | X |
Hemorrhage | |
Hydrocephalus | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Interstitium, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
Foreign Body | |
Mucosa, Inflammation, Acute | |
Mucosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 3 |
Retina, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + |
Nephropathy, Chronic | 3 3 4 3 2 2 4 3 4 4 3 4 4 4 |
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6| |
DAY ON TEST | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9| |
| 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + +| 30 |
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| 31 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| 30 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 1 1 2| 8 1.5|
Degeneration, Cystic | | 3 2.0|
Eosinophilic Focus | 4 1 4 3 X 4 4 2 2 3 3 4 4 1 2 3 2 2 3 3 2| 42 3.0|
Hypertrophy | 2 2 2 2 2 3 2 2 2 | 29 2.1|
Inflammation, Chronic, Multifocal | 2 | 4 2.0|
Inflammation, Chronic Active | | 1 1.0|
Necrosis | 3 | 2 3.0|
Vacuolization Cytoplasmic | 3 2 4 2 1 3 3 4 2 2 2 2 3 2| 28 2.4|
Bile Duct, Hyperplasia | 4 2 4 3 2 3 3 4 3 2 2 3 4 3 3 4 4 3 2 3 2 3 4 | 47 3.1|
Oval Cell, Hyperplasia | 2 2 2 2 2 | 13 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + +| 32 |
Acinus, Atrophy | 2 4 2 3 1 1 2 3 2 3 | 12 2.3|
Acinus, Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 3 3| 7 2.6|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 3 3| 5 3.0|
Mineralization | | 1 1.0|
Ulcer | 3| 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dysplasia | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6| |
DAY ON TEST | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9| |
| 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + +| 31 |
Degeneration, Chronic | 2 2 3 2 3 2 2 3 2 2 2 3 | 22 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +| 32 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + + +| 31 |
Degeneration, Cystic | | 1 2.0|
Hyperplasia | 2 2 | 5 2.0|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 2 2 | 15 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +| 32 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + I + + + + +| 30 |
Pars Distalis, Cyst | X X| 2 |
Pars Distalis, Hyperplasia | 2 2 3 2 | 6 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +| 31 |
C-Cell, Hyperplasia | 3 2 3 2 2 2 2 2 3 2 3 3 3 3 2 3 2 3| 30 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + +| 34 |
Inflammation, Chronic Active | 2 2 2 1 3 2 2 1 2 2 2 2 3| 23 2.0|
Duct, Dilatation | 3 | 1 3.0|
Duct, Hyperplasia, Squamous | 3 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + M + + + +| 30 |
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | 2 4 2 | 5 2.4|
Metaplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6| |
DAY ON TEST | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9| |
| 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 | 9 2.0|
Seminiferous Tubule, Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +| 33 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Thoracic | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 3 | 2 2.5|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M + + + M + + + + + + + + M + + M M| 24 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + | 20 |
Hyperplasia, Cystic | 2 2 2 2 2 3 2 3 3 2 2 | 20 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + +| 32 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 31 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 31 |
Compression | | 1 |
Hemorrhage | 2 2 | 2 2.0|
Hydrocephalus | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + +| 32 |
Interstitium, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + +| 31 |
Foreign Body | 2| 1 2.0|
Mucosa, Inflammation, Acute | 2| 1 2.0|
Mucosa, Inflammation, Chronic Active | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + +| 31 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6| |
DAY ON TEST | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9| |
| 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
3-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Lens, Cataract | 3 3 | 4 3.0|
Retina, Atrophy | 4 4 | 4 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + +| 32 |
Nephropathy, Chronic | 3 3 3 1 3 3 4 3 4 4 3 3 2 3 3 4 4 4| 32 3.3|
Cortex, Cyst | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +| 31 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|
| 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 2 1 1 2 1 1|
Clear Cell Focus | |
Degeneration, Cystic | 2 2 2 2 2 |
Eosinophilic Focus | 4 4 4 2 4 3 3 4 3 3 4 3 2 3 3 4 2 2 4 4 3 3 1 3 3|
Hypertrophy | 3 2 2 2 2 1 2 1 2 2 2 1 2|
Inflammation, Chronic | 2 |
Inflammation, Chronic, Multifocal | 2 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 3 3 4 3 4 3 3 2 3 2 4 4 2 4 2 3|
Bile Duct, Hyperplasia | 3 4 3 3 3 3 3 2 3 4 3 2 2 2 3 4 4 2 3 3 4 2 3 3 3|
Oval Cell, Hyperplasia | 2 2 2 2 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + |
Necrosis | |
Acinus, Atrophy | 3 1 1 3 2 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 3 |
Erosion | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 3 3 |
Ulcer | 4 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Mineralization | 2|
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + |
Degeneration, Chronic | 3 2 3 3 3 2 3 2 2 2 3 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|
| 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + |
Atrophy | |
Degeneration, Cystic | |
Hyperplasia | 2 2 |
Hypertrophy | 2 2 |
Vacuolization Cytoplasmic | 2 1 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + |
Hyperplasia | 2 |
Necrosis | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 1 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 3 3 3 3 2 2 3 2 2 2 3 2 3 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 3 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 3 1 2 4 |
Metaplasia, Squamous | 1 3 |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 3 4 |
Seminiferous Tubule, Mineralization | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|
| 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + |
Mandibular, Hyperplasia, Lymphoid | 3 |
Mediastinal, Congestion | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
__________________________________________________________________________|
Lymph Node, Thoracic | + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Cyst | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + |
Depletion Lymphoid | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
Hyperplasia, Cystic | 2 3 3 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + |
Compression | X X X X |
Hemorrhage | |
Hydrocephalus | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + |
Mucosa, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | |
Lens, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Nephropathy, Chronic | 2 4 2 4 3 4 4 3 2 4 3 4 3 4 3 4 |
Cortex, Cyst | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|
| 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + |
Hemorrhage | 4 |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6| |
DAY ON TEST | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7| |
| 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + +| 29 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + +| 30 |
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + +| 29 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 2 2 1 3 1 1 | 15 1.5|
Clear Cell Focus | 2 | 1 2.0|
Degeneration, Cystic | 2 2| 7 2.0|
Eosinophilic Focus | 3 3 1 3 4 4 2 2 4 2 2 2 3 3 3 4 3 3 1 3 3 3| 47 3.0|
Hypertrophy | 3 2 1 2 2 2 2 2 1 2 2 2 2 2 | 27 1.9|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Chronic, Multifocal | 2 3 | 4 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 3 3 2 3 3 2 3 3 2 2 2 2 2 2 2 2| 32 2.7|
Bile Duct, Hyperplasia | 4 2 2 4 2 3 2 2 3 3 3 2 3 3 2 3 3 2 4 3 3 3 4 2| 49 2.9|
Oval Cell, Hyperplasia | 1 1 2 3 3 2 2 3 2 2 | 23 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + + + + + + + + + +| 31 |
Necrosis | 4 | 1 4.0|
Acinus, Atrophy | 2 1 4 2 2 1 2 2 2| 16 2.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 3 3 2 3 | 8 2.9|
Erosion | 2 | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 3 3 3 | 5 3.0|
Ulcer | 3 | 4 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2| 1 2.0|
Mineralization | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6| |
DAY ON TEST | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7| |
| 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + +| 31 |
Degeneration, Chronic | 3 3 2 3 2 2 2 3 2 3 2 2| 23 2.5|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + M + + + + + + + + + + + + + + + +| 30 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + M + + + + + + + + + + + + + + + +| 30 |
Atrophy | 3 | 1 3.0|
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia | 2 2 | 4 2.0|
Hypertrophy | | 2 2.0|
Vacuolization Cytoplasmic | 2 2 3 1 2 2 2 2 2| 14 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + +| 30 |
Hyperplasia | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + +| 30 |
Hyperplasia | | 1 2.0|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +| 29 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +| 34 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 3 3 2 2 2| 8 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + A + + + + + + + + + + + + + + + +| 30 |
C-Cell, Hyperplasia | 3 3 3 2 3 2 3 2 3 2 3 3 3 3 3 3| 29 2.7|
Follicle, Cyst | X | 1 |
Follicular Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + +| 30 |
Inflammation, Chronic Active | 2 | 2 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + +| 32 |
Inflammation, Chronic Active | 3 4 2 3 2 2 2 2 2 3 2 2 2 4 | 25 2.3|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6| |
DAY ON TEST | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7| |
| 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + +| 31 |
Inflammation, Chronic Active | 2 1 2 1 2 | 10 2.1|
Metaplasia, Squamous | 1 | 3 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 1 2 | 4 1.8|
Seminiferous Tubule, Atrophy | 3 | 3 3.3|
Seminiferous Tubule, Mineralization | | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + + + + + + +| 30 |
Femoral, Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + + + + + + + + +| 31 |
Mandibular, Hyperplasia, Lymphoid | 4 3 | 3 3.3|
Mediastinal, Congestion | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Thoracic | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + M + + M + M + + + + + + + + +| 27 |
Depletion Lymphoid | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + M| 18 |
Hyperplasia, Cystic | 2 2 3 2 2 2 2 3 3 2 | 18 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + +| 32 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 31 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 31 |
Compression | | 4 |
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | | 4 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + +| 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6| |
DAY ON TEST | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7| |
| 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
10 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-3 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + A + + + + + + + + + + + + + + + +| 30 |
Mucosa, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + +| 31 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cornea, Inflammation, Chronic Active | 3 | 1 3.0|
Lens, Cataract | 4 3 | 2 3.5|
Retina, Atrophy | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + +| 37 |
Nephropathy, Chronic | 4 4 2 4 3 3 4 4 3 3 4 3 3 3 4 2 4 2 3 3| 36 3.3|
Cortex, Cyst | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + + + + + +| 30 |
Hemorrhage | | 1 4.0|
Mucosa, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|
| 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 2 |
Clear Cell Focus | 2 |
Degeneration, Cystic | 3 |
Eosinophilic Focus | 4 3 4 4 4 4 3 4 4 4 4 4 4 3 4 4 4 4 4 4 4 3 4 4|
Hypertrophy | 3 2 2 2 2 2 2 2 2|
Inflammation, Chronic, Multifocal | 2 2|
Metaplasia | |
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 1 2 2 2 3 2 2 3 3 3 3 2 2 2 1 3 |
Bile Duct, Hyperplasia | 3 4 3 3 4 3 3 2 2 3 2 2 4 3 2 3 3 3 3 3 3 3 2 3 3|
Oval Cell, Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2|
__________________________________________________________________________|
Mesentery | + + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 2 1 2 3 3 3 3 2 1 2 4 2 4 2 3 3 2 3 2 |
Acinus, Cytomegaly | 2 |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 4 |
Acanthosis | 4 2 4 3 3 |
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | 3 2 3 3 3 |
Ulcer | 2 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Mineralization | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|
| 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Degeneration, Chronic | 2 3 2 2 2 2 2 2 2 2 2 3 3 2 3 3 2 3 2 2 2 3 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 3|
Hypertrophy | 2 2 1 2 2 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 2 2 2|
Capsule, Ectopic Tissue | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 2 |
Hypertrophy | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 2|
Pars Distalis, Vacuolization | |
Cytoplasmic | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
C-Cell, Hyperplasia | 2 2 3 3 2 2 2 2 3 2 2 3 2 3 2 2 2 2 2 2 3 2 2 2 3|
Follicular Cell, Cytoplasmic | |
Alteration | |
Follicular Cell, Hypertrophy | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Preputial Gland | + + M + + + M + + M + + + + + + + + + + + + + M +|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 |
Duct, Dilatation | 3 3 |
Duct, Hyperplasia, Squamous | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic Active | 2 2 2|
Metaplasia, Squamous | 2 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|
| 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Seminiferous Tubule, Atrophy | 3 4 3 4 3 |
Seminiferous Tubule, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + |
Mandibular, Hyperplasia, Lymphoid | 3 |
Mandibular, Inflammation, Chronic, | |
Multifocal | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Thrombosis, Multiple | X |
__________________________________________________________________________|
Thymus | + + + + + M + M + + + + + M M + + + + M + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 2 2 1 2 2 2 2 3 2 2 3 2 2 3 3 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 2 |
Interstitium, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|
| 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic, Multifocal | 2 |
Nephropathy, Chronic | 2 4 3 2 2 3 2 3 4 4 3 4 4 3 3 3 3 3 3 3 2 3 3 4 3|
Cortex, Cyst | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7| |
DAY ON TEST | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3| |
| 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | 2 X 2 2 2 2 | 8 2.0|
Clear Cell Focus | | 1 2.0|
Degeneration, Cystic | | 1 3.0|
Eosinophilic Focus | 4 4 4 4 4 3 4 3 3 4 4 3 4 4 3 2 4 3 3 4 4 4| 46 3.7|
Hypertrophy | 3 2 3 2 2 3 2 1 | 17 2.2|
Inflammation, Chronic, Multifocal | 2 2 | 4 2.0|
Metaplasia | 1 | 1 1.0|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | 2 3 3 2 2 2 1 2 4 2 2 3 2 2 3 2 2 | 34 2.2|
Bile Duct, Hyperplasia | 3 3 4 3 3 2 2 2 3 3 3 2 3 3 3 3 4 2 2 2 3 3 2 3| 49 2.8|
Oval Cell, Hyperplasia | 3 2 3 2 2 2 2 2 1 3 2 3 2 2 1 2 2 4 3| 37 2.2|
__________________________________________________________________________|____________|
Mesentery | | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | 2 3 3 2 2 2 3 2 2 2 3 2 3 2 2 | 35 2.5|
Acinus, Cytomegaly | | 1 2.0|
Acinus, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis, Focal | | 1 4.0|
Acanthosis | 3 3 3 3 2 3 | 11 3.0|
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Chronic Active | 3 3 2 3 | 9 2.8|
Ulcer | 3 2 2 | 6 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7| |
DAY ON TEST | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3| |
| 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Chronic | 2 2 2 3 2 1 2 2 3 2 2 2 2 2 2 2 3| 40 2.2|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 3 3 2 2 2 2 2 2 | 17 2.2|
Hypertrophy | 2 2 | 7 1.9|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | 2 2 4 3 2 2 | 10 2.3|
Capsule, Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Hyperplasia | 2 | 2 2.0|
Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M A + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia | 3 2 3 | 10 2.3|
Pars Distalis, Vacuolization | | |
Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | | 1 2.0|
C-Cell, Hyperplasia | 2 3 2 2 3 2 2 2 2 2 3 2 2 3 3 3 2 2 3 2 2 3| 47 2.3|
Follicular Cell, Cytoplasmic | | |
Alteration | 2 | 1 2.0|
Follicular Cell, Hypertrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7| |
DAY ON TEST | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3| |
| 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + M + + + + + + + + + + + + + + +| 44 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3| 34 2.0|
Duct, Dilatation | 2 | 3 2.7|
Duct, Hyperplasia, Squamous | 3 3| 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Dilatation | 3 | 1 3.0|
Inflammation, Chronic Active | 2 3 2 2 | 7 2.1|
Metaplasia, Squamous | 2 | 3 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 1 2 2 2 2 | 7 1.9|
Seminiferous Tubule, Atrophy | 3 | 6 3.3|
Seminiferous Tubule, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mandibular, Hyperplasia, Lymphoid | | 1 3.0|
Mandibular, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 2 3 2 2 2 2 | 10 2.2|
Thrombosis, Multiple | | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + M + + + + M + + + + + M + + + + + +| 40 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + +| 39 |
Hyperplasia, Cystic | 2 2 3 3 3 3 2 3 2 2 3 3 2 3 2 2 2| 37 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7| |
DAY ON TEST | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3| |
| 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
0-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 2 3 2 | 4 2.3|
Interstitium, Inflammation, Chronic | | |
Active | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mucosa, Inflammation, Chronic Active | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 5 |
Cornea, Inflammation, Chronic Active | 4 | 1 4.0|
Lens, Cataract | 3 3 | 3 3.0|
Retina, Atrophy | 4 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Multifocal | | 1 2.0|
Nephropathy, Chronic | 2 3 3 4 3 3 2 4 4 3 1 3 3 4 4 4 3 3 2 3 4 3 3 3 3| 50 3.1|
Cortex, Cyst | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + A + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5|
| 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 2 1 |
Clear Cell Focus | X |
Congestion | |
Degeneration, Cystic | 2 2 2 |
Eosinophilic Focus | 4 4 4 4 4 4 3 4 3 4 4 4 4 4 4 4 4 4 3 4 4 4 4 3|
Fibrosis | 3 |
Hypertrophy | 2 1 3 2 2 2 2 2 2 2 1 |
Infarct | 3 |
Inflammation, Chronic, Multifocal | 2 1 1 |
Metaplasia | |
Necrosis | 3 1 |
Vacuolization Cytoplasmic | 2 2 2 2 2 1 1 2 3 2 2 2 1 2 3 2 1 2 2 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 3 3 4 4 4 3 3 3 2 3 3 3 3 4 4 3 3 3 3 4 3 4 3 3 4|
Oval Cell, Hyperplasia | 2 2 2 3 3 1 2 2 2 2 2 4 2 2 2 2 3 2 2 3 1 3|
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 2 2 4 3 4 2 2 3 2 2 2 2 2|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Erosion | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Ulcer | 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5|
| 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Degeneration, Chronic | 2 2 2 2 3 2 2 3 3 2 3 2 3 2 3 2 2 2 2 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Spindle Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 2 2 |
Hypertrophy | |
Vacuolization Cytoplasmic | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + A + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 1 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 2 3 3 3 2 2 2 1 1 2 2 3 2 3 3 3 2 3 3 3 3 3|
Follicle, Cyst | X|
Follicle, Hyperplasia, Cystic | 3 |
Follicular Cell, Hyperplasia | 2 |
Follicular Cell, Hypertrophy | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 1 2 2 2 3 3 2 3 2 3 2 2 2 3 2 2 2 |
Duct, Dilatation | 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 2 2 2 2 |
Metaplasia, Squamous | 2 3 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 |
Seminiferous Tubule, Atrophy | 4 2 4 1 4 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5|
| 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sinus, Mandibular, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | I + M + + + M M + M I + + + M M M + + + + M M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia | 3 |
Bronchiole, Epithelium, Hyperplasia | |
Interstitium, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Subacute | |
Mucosa, Inflammation, Chronic Active | 3 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + +|
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + |
Acinus, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 2 2 3 4 3 3 4 2 2 3 2 3 2 2 2 3 3 3 3 3 3 4 3 3|
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7| |
DAY ON TEST | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3| |
| 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 | 5 1.4|
Clear Cell Focus | | 1 |
Congestion | 3 | 1 3.0|
Degeneration, Cystic | | 3 2.0|
Eosinophilic Focus | 4 4 4 4 4 3 4 2 4 3 2 4 4 3 3 2 4 3 4 4 4 4| 46 3.7|
Fibrosis | 3 | 2 3.0|
Hypertrophy | 4 2 3 2| 15 2.1|
Infarct | 4 | 2 3.5|
Inflammation, Chronic, Multifocal | 2 2 | 5 1.6|
Metaplasia | 1 | 1 1.0|
Necrosis | 2 4 | 4 2.5|
Vacuolization Cytoplasmic | 3 2 1 2 2 3 2 2 2 3 2 2 2 2 3 3 2| 37 2.1|
Bile Duct, Cyst | X | 1 |
Bile Duct, Hyperplasia | 4 3 2 3 4 3 4 4 4 3 3 3 3 3 3 3 3 2 3 3 3 3 4 2| 49 3.2|
Oval Cell, Hyperplasia | 1 2 2 2 2 1 2 2 2 3 2 2 3 2 3 2 3 4 2| 41 2.2|
Serosa, Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 4 2 3 2 2 2 2 3 2 2 4 2 3 2| 29 2.5|
Acinus, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 4 3 2 | 6 2.7|
Erosion | 2 | 1 2.0|
Inflammation, Chronic Active | 1 3 3 | 3 2.3|
Ulcer | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7| |
DAY ON TEST | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3| |
| 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | 3 | 1 3.0|
Ulcer | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Degeneration, Chronic | 2 2 2 2 2 3 2 1 3 3 3 2 2 2| 34 2.3|
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Spindle Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 2 2 | 13 2.1|
Hypertrophy | 2 2 | 2 2.0|
Vacuolization Cytoplasmic | 2 2 2 3 3 | 15 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 2 2 | 5 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M M + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Hyperplasia | 2 3 3 3 2 | 10 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 3 3 2 3 2 3 2 2 2 2 3 2 2 2 2 3 2 3 3 2 2 2| 48 2.4|
Follicle, Cyst | | 1 |
Follicle, Hyperplasia, Cystic | | 1 3.0|
Follicular Cell, Hyperplasia | | 1 2.0|
Follicular Cell, Hypertrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 3 2.7|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 4 2 2 2 3 2 2 2 3 2 2 2 2 2 2 2 2| 36 2.2|
Duct, Dilatation | 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7| |
DAY ON TEST | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3| |
| 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 3 3 2 | 10 2.2|
Metaplasia, Squamous | 2 2 3 | 8 2.3|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 | 12 2.0|
Seminiferous Tubule, Atrophy | 4 4 4 3 | 11 3.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femoral, Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Sinus, Mandibular, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 3 2 | 6 2.2|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + M M M M + + M + + M + M + + + + M + M + + + M M| 28 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + +| 30 |
Hyperplasia, Cystic | 2 2 2 2 4 3 3 2 2 2 2 2 3 2| 30 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Alveolar Epithelium, Hyperplasia | 1 | 2 2.0|
Bronchiole, Epithelium, Hyperplasia | 4 | 1 4.0|
Interstitium, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Subacute | 3 | 1 3.0|
Mucosa, Inflammation, Chronic Active | | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05077-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1) Date: 04/29/97
Route: DOSED FEED Time: 10:20:16
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7| |
DAY ON TEST | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3| |
| 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
10-10 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Lens, Cataract | | 1 3.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Acinus, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 2 2 3 3 3 3 4 4 2 4 4 3 4 2 3 3 2 3 4 4 2 2 2 3 2| 50 2.9|
Cortex, Cyst | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
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