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TDMS Study 05077-01 Pathology Tables

NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97
Route: DOSED FEED                                                                                                 Time: 10:20:16




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  67774-32-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3|             
                                           | 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2  1  1  2  2  2  2  3  2  2  2     2  2  3  2  1  3  2  2     2  2  X  X|             
      Clear Cell Focus                     |                                                                   X  X   |             
      Eosinophilic Focus                   |                                     1     1                              |             
      Hematopoietic Cell Proliferation     |       3                                                                  |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic Active         | 2  1        2     2  2  2  2  1     2  2  2  2  2  2  2  2     1  2      |             
      Necrosis                             |       1     1                                                            |             
      Vacuolization Cytoplasmic            |       4                                                     4            |             
      Bile Duct, Hyperplasia               |                      1                          2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Acinus, Atrophy                      |             1  1     2        2  1  1  2                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 2  2  2  2  2     2  2     2  2     1  2  3  2  2  1  2  2     2  2  3  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2     2  2  2  2  3  2  2  2     2        3  2  2     2     2  2  2  2  2|             
      Hypertrophy                          | 2                       2                    2  2              2  3      |             
      Vacuolization Cytoplasmic            |       2  2        2  2     2              1              1  3     2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3|             
                                           | 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                 2           2        2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |             X     X     X     X              X     X     X     X  X  X   |             
      Pars Distalis, Hyperplasia           |                                           3        2              2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2  2  2  2  2  3  3  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          2                 2  2        2  2  2  2     2  2     1  2      |             
      Duct, Dilatation                     |       3           3           3        3  3  3  3  3     3        3     3|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                          3               |             
      Follicle, Cyst                       |                                                                   X      |             
      Periovarian Tissue, Cyst             |          X           X  X     X                          X  X  X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    4              3                 2                                   3|             
      Cervix, Cyst                         |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hyperplasia              |                            3                                             |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +           +                                             |             
      Hyperplasia, Lymphoid                |                            4                                             |             
      Infiltration Cellular, Histiocyte    |                            3                                             |             
      Sinus, Ectasia                       |                4                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  3  3  2  2  3     3     3  2  3  3  3  3  2  3  2  3  2  3  3  3  2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 5| 2| 2| 2| 3| 3| 4| 8| 3| 3| 3| 8| 3| 3| 3| 3| 5| 3| 8| 3| 3| 3| 3|             
                                           | 9| 9| 6| 9| 9| 9| 0| 0| 4| 1| 0| 0| 0| 1| 1| 1| 1| 1| 6| 1| 7| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X              X     X                    X     X                  |             
      Necrosis                             |                   3                                                      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +              +                                 |             
      Nerve, Demyelination                 |                         2              2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +           +                                   +         |             
      Lens, Cataract                       |                3           2                                   3         |             
      Retina, Atrophy                      |                4           4                                   4         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |       4  2     1     1                    1     2     2  2              3|             
      Renal Tubule, Mineralization         |    2                                   2     2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |             X                                                  X         |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | 2  2  2  2  2  2  1  2  2  2  2  2  1  2  2  2     2  2  2  2  2  2  2  2|     47  2.0|
      Clear Cell Focus                     |                                              2                           |      3  2.0|
      Eosinophilic Focus                   |                                                                         3|      3  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                X         |      1     |
      Inflammation, Chronic Active         |          1  2  2  3     1     2  2  2  2  2  2     2  2  2  2        1   |     34  1.9|
      Necrosis                             |    1                                                                     |      3  1.0|
      Vacuolization Cytoplasmic            |                                                                      2   |      3  3.3|
      Bile Duct, Hyperplasia               |       2  1           2  1  2        2        2     2     1     3     1  3|     14  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +                              |   2        |
      Inflammation, Chronic Active         |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |    2           2     1              2              2        1  2     3   |     15  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Chronic                | 2  2  2  2  3  2     3  2  2  3  2  2  3  3  2     2  2  3  2  2     1   |     42  2.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2  3  2  2  2     2  2  2  2  2  2  2  2  2     2  2  2  2  2        2|     39  2.1|
      Hypertrophy                          |    2  2     2  2     2        2                    2  2                 2|     15  2.1|
      Vacuolization Cytoplasmic            |                2        2     2  2  2           3     2        1         |     17  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                         2  2                                             |      6  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  | X        X  X  X           X  X     X                    X  X           X|     20     |
      Pars Distalis, Hyperplasia           | 2        2  2           2  2        2        2  3        2              2|     13  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  | 3  2  3  2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  3|     50  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |             3        2     2     2           2     2  2  2  2  2  3  2  3|     24  2.1|
      Duct, Dilatation                     |          3  3        3                             3  3  3           3  3|     19  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |             3  3                                                         |      3  3.0|
      Follicle, Cyst                       |                                           X                    X         |      3     |
      Periovarian Tissue, Cyst             |                                     X                       X            |      9     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                3              4                                2         |      7  3.0|
      Cervix, Cyst                         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Hyperplasia              |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                           +     +                        |   4        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Sinus, Ectasia                       |                                           4                              |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 2| 3| 3| 3| 3| 3| 3|            |
                                           | 2| 3| 3| 3| 3| 3| 9| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 7| 3| 8| 8| 8| 4| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Cystic                  | 2     2  3  3  3  2  3  3  2  3     2  3  3  2  3  2  3  2  3  3  2  3  2|     46  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                   X                                   X                  |      7     |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
      Nerve, Demyelination                 |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                      +   |   4        |
      Lens, Cataract                       |                                                                      3   |      4  2.8|
      Retina, Atrophy                      |                                                                      4   |      4  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nephropathy, Chronic                 |          2     1  2  1  2  2  1        2  1     1     2  1     1  1  4  1|     25  1.7|
      Renal Tubule, Mineralization         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3|             
                                           | 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          M              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +              +                                +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +              +                                +  +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2                                       |             
      Basophilic Focus                     | 2  2  X  2  1     3  2  2  2  2  2  3  1  2  2  1  1  2  2  2  2     2  2|             
      Degeneration, Cystic                 |                                        1                                 |             
      Eosinophilic Focus                   |    1        1     1  2           X  3  1  1     1  1  1     1        2  2|             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Inflammation, Chronic Active         |    2        1                                         2                  |             
      Vacuolization Cytoplasmic            | 2                       1                                            3   |             
      Bile Duct, Hyperplasia               |       2     1  2  2        2     2  2  2     2              1     1      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +              +                    +              +     +      |             
      Acinus, Atrophy                      |                                              2                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +              +                                   +     +      |             
      Degeneration, Chronic                |                         2                                   2            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +              +                                   +     +      |             
      Hyperplasia                          |          2                                                  2            |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +              +                    +              +     +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +           +  +                    +  +  +     +  +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3|             
                                           | 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                                              X     X                     |             
      Pars Distalis, Hyperplasia           |                                                          2  2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +              +     +                             +     +      |             
      C-Cell, Hyperplasia                  |          3              3     2                             3     3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +              +                 +                 +     +  +   |             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Chronic Active         | 3        2              2                 3                 2     2  4   |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +        +     +     +  +           +     +        +     +      |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |       X           X           X  X           X     X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  |          +              +     +  +                          +     +      |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                               2  4                          3     2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          M              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  |          +              +                                   M     +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +              +                 +              +  M     +      |             
      Hyperplasia, Cystic                  |          2              3                                         2      |             
                                            __________________________________________________________________________|             
   Skin                                    |          +              +                                   +     +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +              +                                   +     +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +              +                                   +     +      |             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
      Nerve, Demyelination                 |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +              +                                   +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 2| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 1| 3| 3|             
                                           | 9| 9| 9| 5| 9| 9| 0| 0| 1| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 9| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |          +              +                                   +     +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +              +                                   +     +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Choroid, Hemorrhage                  |                                                                          |             
      Lens, Cataract                       |                                        4                                 |             
      Retina, Atrophy                      |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +              +                                   +     +      |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 |          1                                                        2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +              +                                   +     +      |             
      Mucosa, Hyperplasia, Papillary       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +     +                    +  +     +           +                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +     +                    +  +     +           +                  |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +     +                    +  +     +           +                  |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +     +                    +  +                 +                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +     +                    +  +                 +                  |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | 1     2  2     2  1  1  2  2  2  1  1  3     2  2  1     1  2  2  1  2  2|     44  1.8|
      Degeneration, Cystic                 |                                                 1                        |      2  1.0|
      Eosinophilic Focus                   |                2  2                                         2  1        1|     19  1.4|
      Hepatodiaphragmatic Nodule           |                                                             X           X|      3     |
      Inflammation, Chronic Active         |       1  1     2  1  2           2     2                 1  1            |     12  1.5|
      Vacuolization Cytoplasmic            |                                  3        4           3                  |      6  2.7|
      Bile Duct, Hyperplasia               |                2           2           1           1  3        1     2   |     18  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   1        |
      Inflammation, Chronic Active         |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +     +                    +  +     +           +                  |  12        |
      Acinus, Atrophy                      | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |          1                                            2                  |      2  1.5|
      Inflammation, Chronic Active         |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +     +                    +  +     +           +                  |  11        |
      Degeneration, Chronic                | 2                                                                        |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +     +                    +  +                 +                  |  10        |
      Hyperplasia                          | 2     2                          2  2                                    |      6  2.0|
      Hypertrophy                          | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Vacuolization Cytoplasmic            | 2     2                                               2                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +     +                    +  +                 +                  |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +     +                    +  +     +           +                  |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M     +                    +  +     M           +                  |   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  34        |
      Pars Distalis, Cyst                  |             X              X                 X     X     X           X  X|      9     |
      Pars Distalis, Hyperplasia           |                                     2           2     3              3  3|      7  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +     +                    +  +     +           +                  |  12        |
      C-Cell, Hyperplasia                  |       2     1                    3  3     2           2                  |     11  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +     +                 +  +  +  +  M           +                  |  15        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 2     2     2                 4  2                    2                  |     13  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +     +  +           +     +  +     +  +        +     +     +  +   |  23        |
      Follicle, Cyst                       |                                                             X            |      1     |
      Periovarian Tissue, Cyst             |                X           X                 X                    X  X   |     11     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +     +                    +  +     +           +     +  +     +  +|  17        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +  +                 +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +                          +                              |   2        |
      Cyst                                 |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +     +                    +  M     +           +                  |   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +     +        +           +  +     +           +  +               |  16        |
      Hyperplasia, Cystic                  | 3     3     2                    3  3     3           3                  |     10  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +     +                    +  +     +           +                  |  11        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +     +                    +  +     +           +                  |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 2| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 7| 3| 6| 3| 5| 3| 3| 6| 6| 6| 6| 4| 2| 7| 6| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +     +                    +  +     +           +                  |  11        |
      Compression                          | X     X                          X                                       |      3     |
      Hydrocephalus                        | 3     3                          2                                       |      3  2.7|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                     +                                    |   2        |
      Nerve, Demyelination                 |                                     2                                    |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +     +                    +  +     +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +     +                    +  +     +           +                  |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +              +               |   3        |
      Choroid, Hemorrhage                  |                                                          3               |      1  3.0|
      Lens, Cataract                       |                                           3                              |      2  3.5|
      Retina, Atrophy                      |                                           4                              |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +                    +  +     +           +                  |  11        |
      Hydronephrosis                       |                                           3                              |      1  3.0|
      Nephropathy, Chronic                 | 2     2                          2  1                 2                  |      7  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +     +                    +  +     +           +                  |  11        |
      Mucosa, Hyperplasia, Papillary       |                                     4                                    |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3|             
                                           | 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +     +              +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +     +              +        +           +  +  +  +      |             
      Diverticulum                         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +                    +        M           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  2     2  3  2  2  2  3  2  2  2     2  2  1  2  1  2           X  2  2|             
      Cytomegaly                           |       1                                                                  |             
      Eosinophilic Focus                   | X  1  1     3     X  X  X     2        3                 1  1  1  X     1|             
      Hepatodiaphragmatic Nodule           |    X                                                                     |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy                          |             2                       3              1     2     2        1|             
      Inflammation, Chronic Active         | 2     3  2     2     3     2           2  2  1                           |             
      Necrosis                             |                                                                   2      |             
      Vacuolization Cytoplasmic            |    1        1           2  1        3           2        4  3  4     1  2|             
      Bile Duct, Hyperplasia               |    2  2  2  2  2  2     2     2     3     2           2  4  3  3     1  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Inflammation, Chronic Active         |                         3                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +                    +        +           +  +  +  +      |             
      Acinus, Atrophy                      |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +                    +        +           +  +  M  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                     2                                    |             
      Mineralization                       |                   3  2                                                   |             
      Ulcer                                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +                    +        +           +  +  +  +      |             
      Degeneration, Chronic                |    2                                                           3  3      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +        +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +        +                    +        +           +  +  +  +      |             
      Hyperplasia                          |                                                                2         |             
      Hypertrophy                          |                                     2                    2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3|             
                                           | 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                3         |             
      Vacuolization Cytoplasmic            |                                     2                    2        2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +        +                    +        +           +  +  +  +      |             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +  +           +        +        +  +        +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                X         |             
      Pars Distalis, Hyperplasia           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +           +                    +        +           +  +  +  +     +|             
      C-Cell, Hyperplasia                  |                3                    3        3           3  3  3  2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +                    +        +           +  +  +  +      |             
      Hyperplasia                          |                                              3                           |             
      Inflammation, Chronic Active         |                2                    2        2           2     2  2      |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +     +     +  +  +  +     +        +           +  +  +  +      |             
      Periovarian Tissue, Cyst             |          X           X  X     X                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |          +     +                    +        +  +     +  +  +  +  +      |             
      Dilatation                           |                                                                   4      |             
      Fibrosis                             |                                                                          |             
      Cervix, Cyst                         |                                                 X        X               |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |          2                                                  2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +                 +  +        +           +  +  M  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                  +  +                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                2                                                         |             
      Hematopoietic Cell Proliferation     |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +                    +        +           +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +        +           M        +           +  +  +  +  +   |             
      Hyperplasia, Cystic                  |                3                             3           3  3  3  4      |             
                                            __________________________________________________________________________|             
   Skin                                    |                +                    +        +           +  +  +  +      |             
      Subcutaneous Tissue, Lip, Foreign    |                                                                          |             
          Body                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 8| 3| 3| 3| 3| 9| 2| 8| 3| 3|             
                                           | 9| 9| 9| 9| 9| 5| 0| 0| 0| 0| 0| 1| 9| 1| 1| 7| 1| 1| 1| 9| 2| 7| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Lip,            |                                                                          |             
          Inflammation, Chronic Active     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +                    +        +           +  +  +  +      |             
      Cranium, Fracture                    |                                                          X               |             
      Femur, Hyperostosis                  |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +                    +        +           +  +  +  +      |             
      Compression                          |                X                             X                           |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                2                             3                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +                    +           +        +  +  +  +      |             
                                            __________________________________________________________________________|             
   Nose                                    |                +                    +        +           +  +  +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +                    +        +           +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +                    +        +           +  +  +  +      |             
      Nephropathy, Chronic                 |                2                    2        2           1     2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +                    +        +           +  +  +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8|            |
                                           | 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                                                              +  +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                                                              +  +     +|  12        |
      Diverticulum                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                                                              +  +     +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | 2  2  2  2  1  2  X  2  2  2  2     2  2  2     2  2  2  1  2        2   |     40  1.9|
      Cytomegaly                           |                                                                          |      1  1.0|
      Eosinophilic Focus                   |       1                       1  3     3           1                     |     19  1.6|
      Hepatodiaphragmatic Nodule           |                                                    X                     |      2     |
      Hyperplasia, Focal                   |                                                             1            |      1  1.0|
      Hypertrophy                          |          1                          1                             2      |      9  1.7|
      Inflammation, Chronic Active         |             2  2  2  2        2        2  2        2        2        1   |     19  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |       2  2                             2  2  4                 3  4      |     18  2.4|
      Bile Duct, Hyperplasia               |    1  2  2     2     2  2  2  2  4  2  2  2  4  2  2        2     2  2   |     34  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                                                              +  +     +|  11        |
      Acinus, Atrophy                      |                                                                1  2      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                                                              +  +     +|  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Diverticulum                         |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                   3     2                       2                        |      5  2.4|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                                                              +  +     +|  12        |
      Degeneration, Chronic                |                                                                2         |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8|            |
                                           | 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                                                              +  +     +|  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                                                              +  +     +|  12        |
      Hyperplasia                          | 2                                                                        |      2  2.0|
      Hypertrophy                          | 2                                                                        |      3  2.0|
      Necrosis                             |                                                                   3      |      2  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                                                              +  +     +|  12        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +        +     +  +     +           +  +  +  +  +     +  +  +  +|  27        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           | 2        3              3                          2  3                  |      6  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +                                               +        +  +     +|  15        |
      C-Cell, Hyperplasia                  | 3                                                     2        3  3     2|     12  2.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                                +                             +  +     +|  12        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 2                                                              2  2     2|     10  2.0|
      Duct, Dilatation                     | 3                                3                                2      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +        +  +        +                                         +  +     +|  19        |
      Periovarian Tissue, Cyst             | X        X  X        X                                                   |      8     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +        +  +                                         +  +  +     +|  18        |
      Dilatation                           |                                                                          |      1  4.0|
      Fibrosis                             |                3                                                         |      1  3.0|
      Cervix, Cyst                         |                                                                          |      2     |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 2                 3                                                      |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                   +      |   3        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 8|            |
                                           | 0| 2| 2| 3| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 6| 4| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                                                              +  +     +|  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                    +                                         +  +     +|  13        |
      Hyperplasia, Cystic                  | 3                                                              3  3     2|     10  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                                            +                 +  +     +|  12        |
      Subcutaneous Tissue, Lip, Foreign    |                                                                          |            |
          Body                             |                                                                         4|      1  4.0|
      Subcutaneous Tissue, Lip,            |                                                                          |            |
          Inflammation, Chronic Active     |                                                                         4|      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                                                              +  +     +|  11        |
      Cranium, Fracture                    |                                                                          |      1     |
      Femur, Hyperostosis                  |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                                                              +  +     +|  11        |
      Compression                          |                                                                X         |      3     |
      Hemorrhage                           | 1                                                                        |      1  1.0|
      Hydrocephalus                        |                                                                3         |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +                                                              +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                                                              +  +     +|  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   2        |
      Lens, Cataract                       |                                        3                                 |      1  3.0|
      Retina, Atrophy                      |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                                                              +  +     +|  11        |
      Nephropathy, Chronic                 | 3                                                              2  2      |      8  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                                                              +  +     +|  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3|             
                                           | 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +        +  +                 +     +                    +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +        +  +                 +     +                    A        +      |             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       2                  |             
      Basophilic Focus                     |       2  3  2  2  2     2  2     3     2  2  2  2     3     2     2  2  2|             
      Eosinophilic Focus                   | 3  2  2  2  2  4  3  2  3  3     4  2  3  4  4  4  4  3     1  3  3  3  2|             
      Hypertrophy                          |       1  1  1  2        1  2  2  2     1  1  2  2  2  2  2           2   |             
      Inflammation, Chronic, Multifocal    |    1           1                       2  2  2  2                    2  2|             
      Inflammation, Chronic Active         |             2     2  2     2  2  2                    2           3      |             
      Necrosis                             |                                                                      1   |             
      Vacuolization Cytoplasmic            | 4  3  2  3  2  2  3  3  2  3  2  3  4  4  2  2  3  3  2  3  4  2  3  2   |             
      Bile Duct, Hyperplasia               | 4  2  2  2     2  3  2           2  3  3     2  2  2           2     3  2|             
      Oval Cell, Hyperplasia               | 3              1                 1              2  2                 2   |             
      Subserosa, Congestion, Multifocal    | 2                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +        +  +                 +     +                    M        +      |             
      Ectopic Liver                        |                                                                   X      |             
      Acinus, Atrophy                      | 3                                                                 2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +        +  +                 +     +                    +        +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                     2                                3   |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                     2                                    |             
      Submucosa, Foreign Body              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Mineralization                       |    2                                                                     |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +        +  +                 +     +                    +        +      |             
      Degeneration, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3|             
                                           | 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +        +  +                 +     +                    A  +     +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +        +  +                 +     +                    A  +     +      |             
      Hyperplasia                          |                                                                   2      |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             | 2                                                                        |             
      Vacuolization Cytoplasmic            |          3                                                  4            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +  +                 +     +                    A  +     +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +        +  +                 +     +                    M        +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +        +  +                 +     +                    +        +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +        +  +        +  +     +     +                    +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
      Pars Distalis, Cyst                  | X                                                                 X      |             
      Pars Distalis, Hyperplasia           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +        +  +                 +     +                    A        +  +   |             
      C-Cell, Hyperplasia                  | 2        3  2                 2     2                             3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +        +  +                 +     +                    +        +      |             
      Hyperplasia                          |             2                                                            |             
      Inflammation, Chronic Active         |                                     2                                    |             
      Duct, Dilatation                     |                                     2                    2        3      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +        +  +  +  +           +     +                    +        +     +|             
      Periovarian Tissue, Cyst             |                X  X                                                     X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +           +  +     +                    +        +      |             
      Dilatation                           | 3                                                                        |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +        +  +                 +     +                    A        +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +  +                 +     +                    +        +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +        +  +                 I     M                    +        +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +  +        +  +     +  +  +                    +        +     +|             
      Hyperplasia, Cystic                  | 2        2  3                 3     3                    2        3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| 3| 3|             
                                           | 8| 9| 9| 5| 4| 9| 0| 0| 0| 0| 5| 1| 6| 1| 1| 1| 1| 2| 2| 1| 2| 2| 0| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +                 +     +                    A        +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +        +  +                 +     +                    +        +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +        +  +                 +     +                    +        +      |             
      Compression                          |             X                 X                                          |             
      Hydrocephalus                        |             2                 3                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                   +      |             
      Nerve, Demyelination                 |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +        +  +                 +     +                    +        +      |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +        +  +                 +     +                    A        +      |             
      Mucosa, Inflammation, Chronic Active |                                     2                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +        +  +                 +     +                    +        +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Lens, Cataract                       |                                        4                                 |             
      Retina, Atrophy                      |                                        4                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +        +  +                 +     +                    +        +      |             
      Nephropathy, Chronic                 | 2        2  3                 2     1                             2      |             
      Cortex, Infarct                      |                                                                          |             
      Renal Tubule, Mineralization         |                                     2                    3               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +        +  +                 +     +                    +        +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                 +           +  +              +  +     +               |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                 +           +  +              +  +     +               |  13        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                 +           +  +              +  M     +               |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          1              4                                      2         |      4  2.3|
      Basophilic Focus                     | 4  3  2  2  X  2  3  2  2  2  1        2  2           2  2  2  2  3  2  2|     37  2.2|
      Eosinophilic Focus                   | 4  3  4  2  2  3  2  3  2  3  1  2  4  X  3  3  1     3  4  2  3  3  2  4|     47  2.8|
      Hypertrophy                          |    2  3  1  2  1  2  2  1        2     1  2  1        1           1  1  1|     32  1.6|
      Inflammation, Chronic, Multifocal    |       2  1  2  2              2  2     1  2  2        2     2     1     2|     21  1.8|
      Inflammation, Chronic Active         |    2                    1  2                                   2     2   |     13  2.0|
      Necrosis                             |             2  2                 2        1                              |      5  1.6|
      Vacuolization Cytoplasmic            | 4  3  2  3  3  4     2  2  3  2  2  3  3  3  3  3     2  4  2  3  3  2  2|     47  2.7|
      Bile Duct, Hyperplasia               | 3  2     2  2  3  2  2  2  2  2  2  3  3  3  2  2     3  2  2  3  2  2  2|     39  2.3|
      Oval Cell, Hyperplasia               |                         2           2           2        2     1        1|     12  1.8|
      Subserosa, Congestion, Multifocal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   1        |
      Inflammation, Chronic Active         |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                 +           +  +              +  +     +               |  13        |
      Ectopic Liver                        |                                                                          |      1     |
      Acinus, Atrophy                      |                   2           2                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                 +           +  +              +  +     +               |  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           | 3                                                                        |      3  2.7|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
      Submucosa, Foreign Body              | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                 2                        |      1  2.0|
      Mineralization                       |                                              2                       2   |      3  2.0|
      Ulcer                                |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                 +           +  +              +  +     +               |  14        |
      Degeneration, Chronic                |                   2                                2     2               |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +                 +           +  +              +  +     +               |  14        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +                 +           +  +              +  +     +               |  14        |
      Hyperplasia                          | 3                 2                                                      |      3  2.3|
      Hypertrophy                          |                                  2                                       |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 2                 2              3                       2               |      6  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                 +           +  +              +  +     +               |  13        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +                 +           +  +              +  +     +               |  14        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +           +     +  +     +  +  +  +        +  +  +  +  +  +  +  +  +   |  29        |
      Hyperplasia                          |                                                       2                  |      1  2.0|
      Pars Distalis, Cyst                  |                      X        X     X                                    |      5     |
      Pars Distalis, Hyperplasia           | 3                    3                                                   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +                 +           +  +              +  +     +               |  14        |
      C-Cell, Hyperplasia                  | 3                 3           3  3              3        2               |     12  2.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +              +     +     +  +              +  +     +               |  16        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 3                       2     2                 2  2                     |      6  2.2|
      Duct, Dilatation                     | 3  3              3     2        2                                       |      8  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +              +           +  +  +     +     +  +  +  +              +|  22        |
      Periovarian Tissue, Cyst             | X  X                          X     X     X           X                  |      9     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +        +        +  +        +  +              +  +     +               |  18        |
      Dilatation                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                 +           +  +              +  +     +               |  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                 +           +  +              +  +     +               |  14        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                      3   |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +                 +           M  +              +  +     +               |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +              +  +           +  M        +     +  +     +     +        +|  21        |
      Hyperplasia, Cystic                  | 3                 3           2                 3  2     3               |     13  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +                 +           +  +              +  +     +               |  13        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                 +           +  +              +  +     +               |  14        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                 +           +  +              +  +     +               |  14        |
      Compression                          |                                  X                                       |      3     |
      Hydrocephalus                        |                                  3                                       |      3  2.7|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Nerve, Demyelination                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +                 +           +  +              +  +     +               |  14        |
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +                 +           +  +              +  +     +               |  13        |
      Mucosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +                 +           +  +              +  +     +               |  14        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +     +                                            +         |   4        |
      Lens, Cataract                       |             3     3                                            3         |      4  3.3|
      Retina, Atrophy                      |             4     4                                            4         |      4  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                 +           +  +              +  +     +               |  14        |
      Nephropathy, Chronic                 | 1                 2           1  3                       1               |     11  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 3| 8| 6| 3| 6| 3| 3| 3| 3| 3|            |
                                           | 0| 3| 3| 3| 3| 6| 1| 6| 6| 6| 2| 9| 6| 7| 7| 7| 5| 5| 7| 1| 8| 8| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Infarct                      |                                                 3                        |      1  3.0|
      Renal Tubule, Mineralization         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                 +           +  +              +  +     +               |  14        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3|             
                                           | 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +           +                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +           +                    +           +  +        +  +  +   |             
      Parasite Metazoan                    |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +           +                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +           A                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 2  2  3     2     2  2  2  1  2  3  1        2  2        1  2     2  1  3|             
      Degeneration, Cystic                 |                                           4           2                  |             
      Eosinophilic Focus                   | 4  3  4  3  3  4     2  3  2  2  2     2  4  3  2  2  3  3  4  2        4|             
      Eosinophilic Focus, Multiple         |                                     X                                    |             
      Hypertrophy                          | 1  2  2  2     2     1  1  1     1  1  2  2  2        1  1  1        1  1|             
      Inflammation, Chronic, Multifocal    |                                                 1                 1  1  1|             
      Inflammation, Chronic Active         |                                     2     4  2        2                  |             
      Necrosis                             |                                              2                           |             
      Vacuolization Cytoplasmic            |    3  4  3  2        3  3  2  3     3  4  2  3  2  2     2  3     4  3  3|             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               |    2  2     2  3     2  2  2  3  2  2     3  1  2  2  2  2  2           2|             
      Oval Cell, Hyperplasia               |       1  3  2  3                    1     2                 1            |             
      Periportal, Infiltration Cellular,   |                                                                          |             
           Lymphocyte                      |       4                                               1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +           A                    +           +  +        A  +  +   |             
      Acinus, Atrophy                      |                                        2           2                 4   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                           2              2               |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +           +                    +           +  +        +  +  +   |             
      Degeneration, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +           A                    +           +  +        A  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3|             
                                           | 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +           A                    +           +  +        A  +  +   |             
      Cyst                                 |       X                                                                  |             
      Hyperplasia                          |                                                                      2   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                       1                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +           M                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +           +              +  +  +           +  +  +     +  +  +   |             
      Pars Distalis, Cyst                  |       X                                            X     X               |             
      Pars Distalis, Hyperplasia           |                                  3     2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +           A                    +           +  +        +  +  +   |             
      Atrophy                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                      2   |             
      C-Cell, Hyperplasia                  |       3                                2           2  2        2  2  3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +           A                    +           +  +        +  +  +   |             
      Inflammation, Chronic Active         |       2                                                        2         |             
      Duct, Dilatation                     |                                                       3        2     3   |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +           +                    +        +  +  +        +  +  +   |             
      Periovarian Tissue, Cyst             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +           +                    +     +  +  +  +  +     +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                              4     2                    2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +           A                    +           +  +        A  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +           +                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                   2      |             
      Fibrosis                             |                2                                                         |             
      Hematopoietic Cell Proliferation     |                                                       3                  |             
      Capsule, Hemorrhage                  |                                                                3         |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +           M                    +           +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 3| 0| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 1| 3| 3| 7| 2| 0| 3|             
                                           | 9| 9| 1| 9| 9| 0| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 9| 8| 1| 2| 4| 9| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +        +  M                    +           +  +        +  +  +   |             
      Hyperplasia, Cystic                  |       3                                3           3  3        3  2  3   |             
                                            __________________________________________________________________________|             
   Skin                                    |       +           +                    +           +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +           +                    +           +  +        +  +  +   |             
      Femur, Hyperostosis                  |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +           A                    +           +  +        +  +  +   |             
      Compression                          |                                                       X              X   |             
      Hydrocephalus                        |                                                       2              2   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Nerve, Demyelination                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +           +                    +           +  +        +  +      |             
                                            __________________________________________________________________________|             
   Nose                                    |       +           A                    +           +  +        +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +           A                    +           +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +           +                    +           +  +        +  +  +   |             
      Nephropathy, Chronic                 |       2                                1              2           1  2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +           A                    +           +  +        +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|            |
                                           | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +              +                                                        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +                                                        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +              +                                                        +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +              +                                                        +|  11        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +              +                                                        +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +              +                                                        +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +              +                                                        +|  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                      1   |      1  1.0|
      Basophilic Focus                     |       2  1  2     2  2  2  2  3  2  2  2  2  2  4  2  2  X        2      |     36  2.0|
      Degeneration, Cystic                 |                                                                          |      2  3.0|
      Eosinophilic Focus                   | 4  2  2  4  4  2  3  3  3  X  2  3  3  4  3  3  4  4  4  4  3  3  3     3|     45  3.0|
      Eosinophilic Focus, Multiple         |                                                                          |      1     |
      Hypertrophy                          |          3  2  1  3  3  2  1  1  1  1  1  1  2  2  1  1     1  1  2  2  2|     39  1.5|
      Inflammation, Chronic, Multifocal    |                1  1           1                       1                  |      8  1.0|
      Inflammation, Chronic Active         |       2  2              2                    2           2     1  2  2   |     12  2.1|
      Necrosis                             |          1                 1           1                    1            |      5  1.2|
      Vacuolization Cytoplasmic            | 4  2  3     2  2  3  2  2  2  3  2  3  3  3  2  3  3  3  2  3  2  3  2  4|     43  2.7|
      Bile Duct, Cyst                      |                                                                      X   |      1     |
      Bile Duct, Hyperplasia               | 3     2  2  2     2  2  2     2  2  2  2  2     1  2  2  2     1  2  2  2|     38  2.0|
      Oval Cell, Hyperplasia               | 3                 1           1     2  3  2  2  1        2        1  1  2|     19  1.8|
      Periportal, Infiltration Cellular,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   1        |
      Inflammation, Chronic Active         |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +              +                                                        +|   9        |
      Acinus, Atrophy                      |                2                                                         |      4  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +              +                                                        +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           | 3                    3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                      2                       2                    2  2   |      6  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|            |
                                           | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +              +                                                        +|  11        |
      Degeneration, Chronic                |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +              +                                                        +|   9        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis                             | 3                                                                        |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +              +                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +              M                                                        +|   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +        +  +     +  +  +     +  +  +     +     +  +     +  +     +|  28        |
      Pars Distalis, Cyst                  |                X  X                       X                    X        X|      8     |
      Pars Distalis, Hyperplasia           |                            3        3                          3  3      |      6  2.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +              +                                                        +|  10        |
      Atrophy                              |                                                                         3|      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 3              3                                                        3|     10  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +              +                                                        +|  10        |
      Inflammation, Chronic Active         |                2                                                         |      3  2.0|
      Duct, Dilatation                     |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +              +  +                                            +        +|  14        |
      Periovarian Tissue, Cyst             |                   X                                            X         |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +     +     +                 +           +  +                 +|  21        |
      Hemorrhage                           | 3                                                                       4|      2  3.5|
      Inflammation, Acute                  |                                                                         4|      1  4.0|
      Necrosis                             |                                                                         4|      1  4.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 2  2                                               2  2                  |      7  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +              +                                                        +|   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|            |
                                           | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +                                         +              +|  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                          +               |   1        |
      Angiectasis                          |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Capsule, Hemorrhage                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M              +                                                        +|   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +              +     +  +     +              +              +           +|  16        |
      Hyperplasia, Cystic                  | 3              3                                                        3|     10  2.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +              +                                                        +|  11        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +              +                                                        +|  11        |
      Femur, Hyperostosis                  |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +              +                                                        +|  10        |
      Compression                          |                X                                                         |      3     |
      Hydrocephalus                        |                3                                                         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                             +            |   1        |
      Nerve, Demyelination                 |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +              +                                                         |   9        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +              +                                                        +|  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +              +                                                        +|  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +              +                 +                           |   3        |
      Lens, Cataract                       |             3              4                 4                           |      3  3.7|
      Retina, Atrophy                      |             4              4                 4                           |      3  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +              +                                                        +|  11        |
      Nephropathy, Chronic                 | 1              2                                                        1|      8  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|            |
                                           | 5| 2| 2| 2| 3| 0| 3| 3| 3| 3| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +              +                                                        +|  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +     M  +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +        +  +                          +                          +|             
      Necrosis                             |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     M  +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             2              2  2  1        3        2  3  2     3  2  X   |             
      Degeneration, Cystic                 |                                                          2               |             
      Eosinophilic Focus                   | 4  4     4  2  2  4  4  4  3     3  4  4  4     4  2  4  4  4  4  4  4  2|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                        X                                 |             
      Hypertrophy                          | 2  1  2  1  1  3  1  1  1     2  2  2  1  1  2  2        2     1  1  1  2|             
      Inflammation, Chronic, Multifocal    | 1                                                        2        1      |             
      Inflammation, Chronic Active         |    2     2           2                    2                          2   |             
      Necrosis                             |                   3              2           3                    1      |             
      Vacuolization Cytoplasmic            | 3  3     3  2  2  2  2  2  2  3  3  3  3  2  2  3  2  2  2  2  2  3  2  4|             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  3  2  2  3  2  2  2  1  2  2  3  2     3  1  2  2  2  2  2  2  2  2|             
      Oval Cell, Hyperplasia               | 2  1  2           2  1  2  2  2  2  2  1  2     2        2     2  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Inflammation, Chronic Active         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +        +  +                          +                          +|             
      Acinus, Atrophy                      |                   2                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                      3        3     2  1              3     2  2     2   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +        +  +                          +                          +|             
      Degeneration, Chronic                |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +        +  +                          +                          +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +        +  +                          +                          +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis                             |                                              4                           |             
      Vacuolization Cytoplasmic            |                3                                                        2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +        +  +                          +                          M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +  +  +     +  +        +  +  +  +                       +  +|             
      Pars Distalis, Cyst                  |                X  X                                                      |             
      Pars Distalis, Hyperplasia           |                   2                    3                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +  +  +                          +                          +|             
      C-Cell, Hyperplasia                  |       3        2  2                          3                          2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +        +  +                          +                          +|             
      Hyperplasia                          |                2                                                         |             
      Inflammation, Chronic Active         |                   2                                                     2|             
      Duct, Dilatation                     |                                              3                           |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +        +  +        +     +  +        +  +  +  +              +  +|             
      Follicle, Cyst                       |                                                                         X|             
      Periovarian Tissue, Cyst             |                            X     X  X           X  X  X              X   |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +        +  +     +                 +  +     +                    +|             
      Cervix, Cyst                         |                                           X                              |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |       2        2                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +        +  +                          +                          +|             
      Mandibular, Necrosis                 |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Necrosis                             |                                              4                           |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +        +  +                          I                          +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +        +                             M                    +     +|             
      Hyperplasia, Cystic                  |       3        2                                                        3|             
                                            __________________________________________________________________________|             
   Skin                                    |       +        +  +                          +                          +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 8| 2| 2| 2| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 9| 9| 5| 9| 9| 1| 1| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +        +  +                          +                          +|             
      Femur, Hyperostosis                  |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +        +  +                          +                          +|             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Nerve, Demyelination                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +           +                          +                          +|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                              3                           |             
                                            __________________________________________________________________________|             
   Nose                                    |       +        +  +                          +                          +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +        +  +                          +                          +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                                   +            |             
      Lens, Cataract                       |                      3  4                                   3            |             
      Retina, Atrophy                      |                      4  4                                   4            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +        +  +                          +                          +|             
      Nephropathy, Chronic                 |       1        1  2                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +        +  +                          +                          +|             
      Calculus Micro Observation Only      |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3|            |
                                           | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +                 +           +                 +     +     +  +      |  12        |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +                 +           +                 +     +     +  M      |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | 2           2  2  1     2  2        2  2  2              1  2        3   |     23  2.0|
      Degeneration, Cystic                 |          2                                                  3            |      3  2.3|
      Eosinophilic Focus                   | 4  2  4  4  4  4  4  4  3  3  4  3  3  4  2  4  4  3  4     3  4     3  4|     45  3.5|
      Hematopoietic Cell Proliferation     |                                                                   2      |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hypertrophy                          |    3  2  2  2  2  3  3  2  2     2  2  1     2  2  3  2     1     1  1   |     40  1.8|
      Inflammation, Chronic, Multifocal    |                2  2     1           1                                    |      7  1.4|
      Inflammation, Chronic Active         |                                        2              2           2      |      8  2.0|
      Necrosis                             |                                                                   2      |      5  2.2|
      Vacuolization Cytoplasmic            | 3  3  2  3  2     3  2  3  3     4  2  2  2  2  3     2     3  3     3   |     43  2.5|
      Bile Duct, Cyst                      |          2                                                               |      1  2.0|
      Bile Duct, Hyperplasia               | 3  2  2  2  2  3  2  2  2  2  3           2  3  2  3  2  2  1  3        2|     44  2.2|
      Oval Cell, Hyperplasia               | 2     1  3  2  2  1  1  1  2  1        2  3  3  2     1     1        2  2|     34  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                 +  +               |   4        |
      Inflammation, Chronic Active         |                                     2                 3                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +                 +           +                 +     +     +  +      |  12        |
      Acinus, Atrophy                      |    2                                               3                     |      3  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                  3                                       |      1  3.0|
      Ulcer                                |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                1                             1                           |     10  2.0|
      Ulcer                                |                                  2                 2           2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3|            |
                                           | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +                 +           +                 +     +     +  +      |  12        |
      Degeneration, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +                 +           +                 +     +     +  +      |  12        |
      Hyperplasia                          |                      2                                         3         |      2  2.5|
      Hypertrophy, Focal                   |    4                                                                     |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |                      2           2                             2  1      |      6  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +                 +           M                 +     +     +  +      |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +        +  +  +  +           +     +  +        +  +  +  +  +  +      |  27        |
      Pars Distalis, Cyst                  |                                                             X            |      3     |
      Pars Distalis, Hyperplasia           |    3                             2     3  2                 2  2         |      8  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +                 +           +                 +     +     +  +      |  13        |
      C-Cell, Hyperplasia                  |    3                 2           3                 2     3     2  3      |     12  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +                 +           +                 +     +     +  +     +|  13        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                      2           3                       2               |      5  2.2|
      Duct, Dilatation                     |                                                          2     2        3|      4  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +                 +     +     +                 +     +     +  +      |  20        |
      Follicle, Cyst                       |                                                                          |      1     |
      Periovarian Tissue, Cyst             |                            X                                             |      8     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +           +        +  +           +  +  +     +     +  +      |  20        |
      Cervix, Cyst                         |                                              X                    X      |      3     |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |          2                    3                    2           2         |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    I                 +           +                 +     +     +  +      |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +           +           +                 +     +     +         |  12        |
      Mandibular, Necrosis                 |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3|            |
                                           | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +                                               +           +         |   3        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  49        |
      Fibrosis                             |                2                                               3         |      2  2.5|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +                 +           +                 +     M     +  +      |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +                 +           +                 +     +     +  +      |  11        |
      Hyperplasia, Cystic                  |    3                 2           3                 3     2     3         |      9  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +                 +        +  +                 +  +  +     +  +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                 +           +                 +     +     +  +      |  12        |
      Femur, Hyperostosis                  |    X                                                                     |      2     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +                 +           +                 +     +     +  +      |  12        |
      Compression                          |                      X                                                   |      1     |
      Hydrocephalus                        |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
      Nerve, Demyelination                 |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +                 +           +                 +     +     +  +      |  11        |
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +                 +           +                 +     +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                 +           +                 +     +     +  +      |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +     +                  |   5        |
      Lens, Cataract                       |                                                 3     3                  |      5  3.2|
      Retina, Atrophy                      |                                                 4     4                  |      5  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +                 +           +                 +     +     +  +      |  12        |
      Nephropathy, Chronic                 |    1                 1           2                       2     2         |      8  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +                 +           +  +              +     +     +  M      |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 2| 7| 7|            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 3| 2| 3| 5| 7| 3| 3|            |
                                           | 3| 4| 3| 3| 3| 6| 6| 8| 6| 6| 6| 0| 7| 7| 7| 7| 7| 3| 8| 9| 8| 2| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Calculus Micro Observation Only      |                                     X                                    |      1     |
      Mucosa, Hyperplasia, Papillary       |                                     3                                    |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5|             
                                           | 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X              X           X              X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1     2     2                    2  2     2           2  3           2   |             
      Eosinophilic Focus                   | 4  4  4  4  2  4  4  4     4  4  4  2  4  4  4  4  3  4  4  4  4  4  4   |             
      Hypertrophy                          | 3     3  2  2  3        2                 3     3  3                    3|             
      Inflammation, Chronic, Multifocal    | 2  2  2  2     2     2  2  2     2  2  2        2  2  2  2  2  2  2  2   |             
      Inflammation, Chronic Active         |             2                             2                              |             
      Necrosis                             |                                     3                                    |             
      Vacuolization Cytoplasmic            | 3  2  3  2  2  2  2  2  3  3  2  3  4  3  2  1  3  3  3  3  3  3  3  3  4|             
      Bile Duct, Cyst                      |                                  2                                       |             
      Bile Duct, Fibrosis                  |                   2                                                      |             
      Bile Duct, Hyperplasia               | 3  2  3  2  2  2  2  3  2  2  3  2  2  2  3  2  3  2  3  3  2  3  3  2  2|             
      Bile Duct, Metaplasia                |                                                             1            |             
      Oval Cell, Hyperplasia               | 2  2  3  1     2  3  2     2  2  3  3           3  3  3     4  3  3  3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2  2     1  3  4  2  2     2  3  2  2     3  2        3     4  2  2      |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly, Focal                    |                                                             2            |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                |       1     2  2     2        2  2  2     2        2  2  2  2        1   |             
      Myocardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5|             
                                           | 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2           2        3  2                    2  3  2  4     3  2  3  3   |             
      Hypertrophy                          |    2  2  2                                      3  2  2           2     2|             
      Vacuolization Cytoplasmic            |       2  2  2  2     2  2  2        3                          2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                 X                        |             
      Pars Distalis, Hyperplasia           | 3  2                 2                    3           2                 2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      C-Cell, Hyperplasia                  | 2  2  2  2  3  2  2  3  3  2  3        3  2  2  3  2  3  2  2  2  2  2   |             
      Follicle, Cyst                       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2     2  2     2  2           2  2                 2           2  2   |             
      Duct, Dilatation                     |       3        3     3     3        3  3  3  3  3  3  3  3  3  3     3   |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                 X           X           X|             
      Rete Ovarii, Hyperplasia             |                                                             3            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 2        3  2  3                                3  3              3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Angiectasis              |                                                          3               |             
      Mediastinal, Angiectasis             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                     3                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 3| 9| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5|             
                                           | 9| 9| 9| 9| 0| 0| 3| 0| 8| 0| 1| 1| 4| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  3  3  3  2  3  3  2  3     3  2  3  3  2  3  3  4  3  2  3  2  3|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Mucosa, Inflammation, Chronic Active |    2                                                     3               |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                 +                  |             
      Lens, Cataract                       |                                                       3                  |             
      Retina, Atrophy                      |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  1  2  1  2     2  2  1        2  1  1  2  1  1  1  1  2  2  1  2   |             
      Renal Tubule, Mineralization         |          2              3                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7|            |
                                           | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                              X           X               |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                        2                          3      |     11  2.1|
      Eosinophilic Focus                   | 4  2  4  4  4  4  4  4  4  4  4  4  4  4  1  4  4  4  2  3  4  3  4  3  4|     48  3.7|
      Hypertrophy                          |    4  2  3              3     4     2                             3      |     17  2.8|
      Inflammation, Chronic, Multifocal    |       2     2  2  2  2     2     2           2  2     2     2     2      |     31  2.0|
      Inflammation, Chronic Active         |                                                          2               |      3  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            | 3  3  2  2  3  3  2  2  3  3  4  2  3  2  2  2  2  3  3  2  3  3  3  2  3|     50  2.6|
      Bile Duct, Cyst                      |                                                                   3      |      2  2.5|
      Bile Duct, Fibrosis                  |                      2                             2                     |      3  2.0|
      Bile Duct, Hyperplasia               | 2  2  2  2  3  3  3  3  3  2  3  2  2  2  2  2  3  3  2  2  3  3  2  2  2|     51  2.4|
      Bile Duct, Metaplasia                |                                                                          |      1  1.0|
      Oval Cell, Hyperplasia               | 3  3  2  3  3  3  3  3  3  3  3  3  3  3     3  3  4  3  3  3  4  3  3  3|     42  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 3  2  1  1           2        4  4  2                    2     2  2  2   |     29  2.3|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cytomegaly, Focal                    |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                        2                                 |      1  2.0|
      Ulcer                                |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Chronic                | 2        2        1                    3     2              2  2     2   |     21  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7|            |
                                           | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Myocardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                      3   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2  2     2        2        2     3  2                     |     19  2.4|
      Hypertrophy                          |                                                    2                     |      9  2.1|
      Vacuolization Cytoplasmic            |       2  3  1     2                    2     2  3     2     3            |     18  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           | 3        3        2  3     2        2        2                           |     13  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  |    2  2  3  2  2  2     2  3     2  2  3  2  2  2  2  2  2  3  2  2     2|     43  2.3|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Inflammation, Chronic Active         |       2        2     2           2  2  2  2     2  2        2  2     3   |     22  2.0|
      Duct, Dilatation                     | 3  3  3                 3  3              3  3  3  3     3        3      |     26  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicle, Cyst                       |                                                             X            |      1     |
      Periovarian Tissue, Cyst             | X           X           X           X  X  X  X                          X|     11     |
      Rete Ovarii, Hyperplasia             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |    3                       2     3           2              3            |     12  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7|            |
                                           | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mandibular, Angiectasis              |                                                                          |      1  3.0|
      Mediastinal, Angiectasis             |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                          +           +  +                          +   |   5        |
      Angiectasis                          |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    | +                          +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  I  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Hyperplasia, Cystic                  | 3  2  3  3  3  2  3  3  3  3  3  3  3  3     2  3  3  3  2  3  4  3     2|     47  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                        3                                 |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femur, Hyperostosis                  |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Focal, Granulomatous   |                                                          2               |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                  3                    1                  |      2  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mucosa, Inflammation, Chronic Active |                                     2  2                                 |      4  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Lens, Cataract                       |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5| 7| 7| 7| 4| 7| 7| 6| 6| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 4| 8| 1| 3| 3| 0| 9| 3| 3| 5| 3| 3| 7|            |
                                           | 3| 7| 3| 3| 3| 6| 6| 8| 6| 7| 4| 7| 2| 4| 6| 7| 7| 4| 1| 8| 8| 9| 2| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2     1  2  1  2  1     3  2     2  1  1     1           2  2     2     1|     37  1.6|
      Renal Tubule, Mineralization         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 3  4     2  3     X                 3                 2  2               |             
      Cytomegaly                           |                                                                          |             
      Eosinophilic Focus                   | 4  4  4  4  4  3  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  2  4  4|             
      Hypertrophy                          |                   2                    3              2                  |             
      Inflammation, Chronic, Multifocal    | 2  2     2  2        2  2        2  2        2     2  2     2            |             
      Inflammation, Chronic Active         |                                                          2               |             
      Inflammation, Multifocal             |                                                                          |             
      Necrosis                             |                                     2                                    |             
      Thrombosis                           |                                           X                              |             
      Vacuolization Cytoplasmic            | 2  3  4  4        3  3  2  2  2  2  2  3     2  3  3  3  3  2        2  2|             
      Bile Duct, Cyst                      |                                  X           X                           |             
      Bile Duct, Fibrosis                  |    2        2                 3     2     2           2  3           3   |             
      Bile Duct, Hyperplasia               |          3                    2  2  2  2              3        4         |             
      Oval Cell, Hyperplasia               | 3  3  4  4  3     3  3  3  3  4  3  3  3  4  3  3  3  3  3  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change, Multiple      |                                                                          |             
      Acinus, Atrophy                      |       2  3        3        1     3  1        3           3  2     3  3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       2                                                           2      |             
      Inflammation, Chronic Active         |       2                                                                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia, Focal                     |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                |                      1  2        2     2                          2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |    2  2              2  2  2     3        2  3        2           2     3|             
      Hypertrophy                          |             2  2              1  3                                       |             
      Vacuolization Cytoplasmic            | 2     2  2           2  2     3  3  2        2     2  2     3           2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 2  3     2        3        2        3                                2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3  2  2  2  2     2  2  2  2  2  3  3  3  3  2  2     2  2  3  2  3  2  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2  2        2  2     2                          2                 2   |             
      Duct, Dilatation                     | 3        3  3     3        3  3  3  3  3     3  3     3  3  3            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Cyst             |                      X     X                          X           X     X|             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Cervix, Cyst                         |          X                                                               |             
      Cervix, Mucosa, Hyperplasia, Squamous|                                                                         2|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                         2           3        3                          3|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +|             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 7| 2| 2| 0| 3| 3| 3| 3| 1| 3| 3| 8| 7| 3| 3| 9| 3| 3| 3| 9| 3| 3| 3|             
                                           | 9| 9| 7| 9| 9| 6| 0| 0| 0| 0| 0| 1| 1| 2| 4| 1| 1| 5| 1| 2| 2| 9| 3| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  3  2  3  2  2     2  3  3  3  1  3  2  2     2  3  3  3  3     3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Osseous           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Chronic Active |                                  3                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                 +                                 |             
      Lens, Cataract                       |                      3                                                   |             
      Retina, Atrophy                      |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1     1  2  2     2  1  1  1  1  2  2  1  1     1     1  2  2  1     1  1|             
      Renal Tubule, Inflammation, Acute,   |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3|            |
                                           | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Parasite Metazoan                    |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       3  3  2  2                                                  2      |     13  2.6|
      Cytomegaly                           |                                                                3         |      1  3.0|
      Eosinophilic Focus                   | 4  4  4  4  4  4  4     3  2  4  4  4  4  3  4  4  3  4  4  4     4  4  4|     47  3.8|
      Hypertrophy                          |             3  2     3                                                   |      6  2.5|
      Inflammation, Chronic, Multifocal    |    2  2  2  2  2           1  2  2     2                                2|     22  2.0|
      Inflammation, Chronic Active         |                                                 2                        |      2  2.0|
      Inflammation, Multifocal             |                                                             2            |      1  2.0|
      Necrosis                             |          3  2                                                            |      3  2.3|
      Thrombosis                           |                                                                          |      1     |
      Vacuolization Cytoplasmic            | 2     3     2  3  2  4  3     3  3  2  2  4  2  3  3  4  3  3  2  3      |     40  2.7|
      Bile Duct, Cyst                      |          X                                         X           X         |      5     |
      Bile Duct, Fibrosis                  | 3     3        3  3                 2     3  2        3  4  3     3      |     19  2.7|
      Bile Duct, Hyperplasia               |                   2  3              3     2  2  2           2  2         |     15  2.4|
      Oval Cell, Hyperplasia               | 3  3  4  3  3  3  3     3  1  3  3     3  3  3  2  3  4  4        3     3|     44  3.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Focal Cellular Change, Multiple      |                                  2                                       |      1  2.0|
      Acinus, Atrophy                      | 2     1  4  2  3  3              3     3     1  2        4     2  3  2   |     25  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                               2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |       2                                   2           2                  |      5  2.0|
      Inflammation, Chronic Active         |       3                                               2                  |      3  2.3|
      Ulcer                                |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia, Focal                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3|            |
                                           | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Chronic                |                                  2  2           2        2  2  2         |     11  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                              X  X                        |      2     |
      Hyperplasia                          |             2  2        3              3     2  3           3  2  2     3|     21  2.4|
      Hypertrophy                          |             2  2                                   3  2                 2|      9  2.1|
      Vacuolization Cytoplasmic            |          2  3  2  2  2  3           1        2     3  2  2        2      |     25  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                     X                                    |      1     |
      Pars Distalis, Hyperplasia           |       3     2                    2              2           2            |     13  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia                  | 2  2  3  2  2  2  2  2  3  2  2     2  3  2  3  3  3  3  3  2  3  3  2  2|     47  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Inflammation, Chronic Active         |                      2        2        2              2  2           4   |     13  2.2|
      Duct, Dilatation                     |       3  3              3           3     3  3  3           3        3   |     23  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Periovarian Tissue, Cyst             |                                     X                    X     X  X      |      9     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                            +                                             |   1        |
      Dilatation                           |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                            3                                             |      1  3.0|
      Cervix, Cyst                         |                                                                X         |      2     |
      Cervix, Mucosa, Hyperplasia, Squamous|                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |             2  2        2              2  2  2  3                        |     11  2.4|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +                                                                 +   |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3|            |
                                           | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Hyperplasia, Cystic                  | 2  3  3  2  2  2  3  2  3        3  3  3  3  2  3  4  3     2  2  2     2|     43  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Focal, Osseous           |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Inflammation, Chronic Active |                                                                         2|      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +     +                                               +      |   5        |
      Lens, Cataract                       |             3     3                                               3      |      4  3.0|
      Retina, Atrophy                      |             4     4                                               4      |      4  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2  2  2  2  1  2  3  1  2     2  2  2  2  1  2  1  1  1  1  1  2  1      |     42  1.5|
      Renal Tubule, Inflammation, Acute,   |                                                                          |            |
           Multifocal                      |                                                                         3|      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 7| 7| 5| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 3| 8| 1| 8| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 0| 0| 3| 3| 3| 4| 3|            |
                                           | 3| 2| 6| 4| 3| 6| 6| 2| 6| 2| 6| 6| 7| 7| 4| 7| 7| 8| 4| 7| 8| 8| 8| 3| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                         4|      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3|             
                                           | 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X              X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                     X        X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1  2  2        3        2              1  3  3     2     1  1  4        2|             
      Clear Cell Focus                     | 1                                                                        |             
      Degeneration, Cystic                 | 2     2                 2        2     2        2        2     2     2  2|             
      Eosinophilic Focus                   | 2              1        1        3                       1  1  2  1     1|             
      Hyperplasia, Focal                   |                                                                   2      |             
      Hyperplasia, Multifocal              |                                  3                             3         |             
      Inflammation, Chronic Active         | 3                                                                        |             
      Vacuolization Cytoplasmic            |          4                 3  3     3                                    |             
      Bile Duct, Hyperplasia               | 4  2  3  4  3  2  3  2  3  3  4  3  4  2  3  2  4  2  3  2  3  2  3  2  3|             
      Centrilobular, Degeneration          |          3                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2  2                 2        2  2  2           2  2        2         |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                            X                                             |             
      Foreign Body                         |                               1                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 3  3  3  3  3  2  2  2  2  2  2  3  3  3  3  2  2  2  3  3  2  2  3  3  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2           3        2        2  2     2        2        2     2  2  2|             
      Hypertrophy                          | 2           2           2                             2           2      |             
      Vacuolization Cytoplasmic            |          4        2           3                 2     2                 1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Hyperplasia                          | 2     2     2           2     3                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3|             
                                           | 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                        X                    X            |             
      Pars Distalis, Hyperplasia           |                      2     2        2                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2|             
      Follicular Cell, Hypertrophy         |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                     2            |             
      Inflammation, Chronic Active         | 2  2  3  2  3  2        2     2  2  3  2  2     2  2  2  2  2     2  2  2|             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2           2  3                             3     4                  |             
      Metaplasia, Squamous                 |    2           2  2                             2     2                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |          2        2                 2        2        1                  |             
      Seminiferous Tubule, Atrophy         |                                                                      4   |             
      Seminiferous Tubule, Mineralization  |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                      +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                             2            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  3  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 1| 2| 1| 5| 2| 2| 7| 5| 2| 0| 9| 2| 1| 2| 2| 5| 7| 2| 9| 2| 2| 2| 3| 7| 3|             
                                           | 4| 7| 3| 1| 7| 7| 5| 5| 8| 6| 4| 8| 0| 8| 8| 1| 1| 9| 9| 9| 9| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   X                                                      |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Nerve, Demyelination                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |          3           3                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |    2                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                           4                              |             
      Nephropathy, Chronic                 | 3  2  3  4  2  3  3  2  3  3  3  2  3  2  2  2  3  4  4  4  3  2  3  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mucosa, Ulcer                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7|            |
                                           | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                X         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | 2        X     1        1        2  1  2  2  1  1  1        1  1  1      |     27  1.7|
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Degeneration, Cystic                 |    2        2     2     2           2     2        3           2         |     18  2.1|
      Eosinophilic Focus                   | 1              1        1  1  1     1        1              1     1      |     18  1.2|
      Hyperplasia, Focal                   |          2                                                               |      2  2.0|
      Hyperplasia, Multifocal              |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                       3                  |      5  3.2|
      Bile Duct, Hyperplasia               | 2  3  4  3  4  3  3  2  2  3  3  2  2  2  2     2  3  3  3  3  3  2  4   |     48  2.8|
      Centrilobular, Degeneration          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Acinus, Atrophy                      |    2  2        2     2  2  2     2  2        2  1        2     2  2  2   |     23  2.0|
      Acinus, Hyperplasia                  |                            3                 2                           |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Foreign Body                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Chronic                | 3  2  2  3  3  2  2  2  1  2  3  2  3  3  3  3  2  2  2  1  2  3  3  3  3|     50  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7|            |
                                           | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |    2  2  2                    2  2        2  2        2                  |     19  2.1|
      Hypertrophy                          |    2     2                                      3                        |      8  2.1|
      Vacuolization Cytoplasmic            |                         1        2                 1     2     2         |     11  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          2              2     2           2           3  2        2      |     13  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Hyperplasia                          |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |    X                                                                     |      3     |
      Pars Distalis, Hyperplasia           |    3                                      2           3     2  3  2      |      9  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2|     48  2.0|
      Follicular Cell, Hypertrophy         |                                           2                              |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                    2                     |      3  2.0|
      Inflammation, Chronic Active         | 2  2  2     2  4  2        3  4  3  2     2  2        2  2     2     2  3|     37  2.3|
      Duct, Dilatation                     |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |       2                          2     2  2                    3     2   |     11  2.5|
      Metaplasia, Squamous                 |       2                          2     2  2                    2     2   |     11  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |             2                             2  2                           |      8  1.9|
      Seminiferous Tubule, Atrophy         |                                  3                             3         |      3  3.3|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Hyperplasia, Reticulum Cell | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Hemorrhage               |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                         +|   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7|            |
                                           | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                        3                                2|      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +     +  +        +  +  +  +  +  +  +  +  +     +  +  +     +   |  39        |
      Hyperplasia, Cystic                  | 2        3     2  2        2  2  2  2  2  3  2  2  3     3  2  3     3   |     38  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |    4                                                                     |      1  4.0|
      Subcutaneous Tissue, Fibrosis        |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                  X        X                              |      3     |
      Hemorrhage                           |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                      +                 +                                 |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                 +                                 |   2        |
      Nerve, Demyelination                 |                      2                 2                                 |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                                                                3         |      1  3.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                3         |      3  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Inflammation, Chronic Active |                   3                                                      |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 3| 8| 9| 3| 0| 3| 3| 0| 3| 3| 3| 3| 3| 5| 7| 3| 3| 3| 0| 3| 3| 3| 3| 9| 7|            |
                                           | 0| 6| 3| 0| 2| 1| 1| 7| 1| 1| 4| 4| 4| 7| 6| 4| 5| 5| 5| 5| 6| 6| 6| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy, Chronic                 | 2  1  2  3  2  2  2  2  2  2  3  2  2  1  4  3  3  3  2  2  2  2  2  3  2|     50  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                      4                                                   |      1  4.0|
      Mucosa, Ulcer                        |                      3                                                   |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|             
                                           | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +     +        +  +           +  +           +  +        +   |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +     +        +  +           +  +           +  +        +   |             
      Dilatation                           |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +     M        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2                                       |             
      Basophilic Focus                     |          1  1  1  1  1  2     1  2  2              1  2        1        1|             
      Clear Cell Focus                     |                                     2                                    |             
      Degeneration, Cystic                 |       2  2                          2                          2     2   |             
      Eosinophilic Focus                   | 4  2  2  2     2        2  X     2  2  2        2  2  3        2        2|             
      Hepatodiaphragmatic Nodule           |                                                       X           X      |             
      Hyperplasia, Focal                   |                            3                                             |             
      Hypertrophy                          |    1                    1           1                                    |             
      Infarct                              |                                                          4               |             
      Inflammation, Chronic                |                                                       2                  |             
      Inflammation, Chronic, Multifocal    |                                  2                                       |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 1  2  3  2  1              2              1     2  2  2     4  2     2   |             
      Bile Duct, Hyperplasia               | 3  2  2  3     4  2  3  3  3  2  3  3  4  3  2  2  3  3     4  3  2  4  3|             
      Centrilobular, Necrosis              |                                                                          |             
      Oval Cell, Hyperplasia               |                1                                            2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                       +                    +               |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +     +        +  +           +  +           +  +        +   |             
      Acinus, Atrophy                      |             3                             1                 2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             3                                            3               |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|             
                                           | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +     +        +  +           +  +           +  +        +   |             
      Degeneration, Chronic                |             2     3                       2                 2        2   |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                   +        +  +           +  +           +  +        +   |             
      Hyperplasia                          |                   2        2                                         2   |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |                            4              2              3  3        2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +     +        +  +           +  +           +  +        +   |             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +     +        +  +           +  +  +        +  +  +     +   |             
      Pars Distalis, Cyst                  |                            X              X                              |             
      Pars Distalis, Hyperplasia           |                                                          2     2         |             
      Pars Intermedia, Hyperplasia,        |                                                                          |             
          Glandular                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +     +        +  +  +        +  +           +  +        +   |             
      C-Cell, Hyperplasia                  |             4              3  3           2  2           3  2        2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                   +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +     +     +        +  +           +  +     +     +  +        +   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |             2     2        2  2           2  3     3        2            |             
      Duct, Dilatation                     |                                                                      3   |             
                                            __________________________________________________________________________|             
   Prostate                                |             +     +        +  +           +  +           +  +        +   |             
      Inflammation, Chronic Active         |             2                             1                 2            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |    2                                                              2      |             
      Seminiferous Tubule, Atrophy         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +     +        +  +           +  +           +  +        +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +     +        +  +           +  +           +  +        +   |             
      Mediastinal, Hyperplasia, Macrophage |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|             
                                           | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                          +               |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   2      |             
      Hematopoietic Cell Proliferation     |                                                          4               |             
      Capsule, Hemorrhage                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +     +        +  M           +  +           I  M        +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +              +  +              +           +  +        +   |             
      Hyperplasia, Cystic                  |             3              2  2              2           3  3        3   |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +  +        +  +        +  +  +           +  +     +  +   |             
      Face, Cyst Epithelial Inclusion      |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +     +        +  +           +  +           +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +     +        +  +           +  +           +  +        +   |             
      Gliosis                              |                                                                      2   |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Nerve, Demyelination                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +     +        +  +           +  +           +  +        +   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |             3     3                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    |             +     +        +  +           +  +           +  +        +   |             
      Mucosa, Inflammation, Chronic Active |                            2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +     +        +  +           +  +           +  +        +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Lens, Cataract                       |                                                                      3   |             
      Retina, Atrophy                      |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +     +  +     +  +           +  +           +  +        +   |             
      Hydronephrosis                       |                                                          3               |             
      Nephropathy, Chronic                 |             4     2  4     2  2           2  2           3  1        1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 5| 7| 7| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 6| 2| 8| 2| 2| 8| 7| 2| 2| 2| 9| 8| 2| 3| 3| 3| 4| 3| 3| 0| 3|             
                                           | 7| 7| 7| 8| 8| 8| 4| 8| 8| 9| 7| 9| 9| 9| 3| 4| 9| 0| 0| 2| 6| 0| 0| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cortex, Cyst                         |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +     +        +  +           +  +           +  +        +   |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1|            |
                                           | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        +  +  +  +     +           +  +  +     +              A     +|  20        |
      Dilatation                           |                                                                         4|      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Dilatation                           |                                                                         4|      1  4.0|
      Parasite Metazoan                    |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +        +  +  +  +     +           +  +  +     +              A     +|  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +        +  +  +  +     +           +  +  +     +              A     +|  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          | 1     1     1                                                            |      4  1.3|
      Basophilic Focus                     |       1              2  1           1                    1     1         |     19  1.3|
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Degeneration, Cystic                 | 2     2     2  2        2        2                    3                  |     12  2.1|
      Eosinophilic Focus                   | 2     1  1              1     3  2  1  2        X     2  2     1     2  2|     29  2.0|
      Hepatodiaphragmatic Nodule           |                                                          X        X      |      4     |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Hypertrophy                          |                                                                          |      3  1.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic                | 1                       2                                   2            |      4  1.8|
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
      Necrosis                             |                                                 2  2                     |      2  2.0|
      Vacuolization Cytoplasmic            |          2        1                    2           2                 2   |     18  1.9|
      Bile Duct, Hyperplasia               | 3     3  2  3  4  4  4  3  3  2  3     4  3  2  2     3  3  2  3  2  3  3|     45  2.9|
      Centrilobular, Necrosis              |                            3                                             |      1  3.0|
      Oval Cell, Hyperplasia               |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +  +           +                              |   6        |
      Inflammation, Chronic Active         |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Acinus, Atrophy                      |             2     2  1                       1                           |      7  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                         4                    2                           |      4  3.0|
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|
      Ulcer                                |                                              3                           |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1|            |
                                           | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                 2                        |      1  2.0|
      Ulcer                                |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Degeneration, Chronic                |             3     2        2           2     2                    3     3|     12  2.3|
      Thrombosis                           |             X                                                            |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +        +  +  +  +     +     +     +  +  +     +              +     +|  22        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +        +  +  +  +     +     +     +  +  +     +              +     +|  21        |
      Hyperplasia                          |                                        2                                 |      4  2.0|
      Hypertrophy                          |                                                                   2      |      1  2.0|
      Vacuolization Cytoplasmic            |    2              2                    2           1              2      |     10  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +        +  +  +  +     +     +     +  +  +     +              +     +|  22        |
      Hyperplasia                          |                                              2                    2      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M        +  +  +  +     +           +  +  +     +  +  +        +  +  +|  27        |
      Pars Distalis, Cyst                  |                                                          X               |      3     |
      Pars Distalis, Hyperplasia           |                3  2                    3                                 |      5  2.4|
      Pars Intermedia, Hyperplasia,        |                                                                          |            |
          Glandular                        |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +  +  +  +     +           +  +  +     +  +           A  +  +|  23        |
      C-Cell, Hyperplasia                  |    2        3  3  3  2     2           3  3  3     2                 3  3|     20  2.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                         +|   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +        +  +  +  +     +           +  +  +     +              +     +|  20        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +        +  +  +  +     +  +  +     +  +  +     +              +     +|  25        |
      Hyperplasia                          |                                                                   2      |      1  2.0|
      Inflammation, Chronic Active         |    2              2        2  3        2  2                             2|     15  2.2|
      Duct, Dilatation                     |                3                                                        4|      3  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Inflammation, Chronic Active         |                                                                   3      |      4  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +                                                  +      |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1|            |
                                           | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           |                                                                   4      |      1  4.0|
      Epithelium, Hyperplasia              |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Interstitial Cell, Hyperplasia       |                3                                                         |      3  2.3|
      Seminiferous Tubule, Atrophy         |                                                    3                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +        +  +  +  +     +     +     +  +  +     +     +        +     +|  23        |
      Mediastinal, Hyperplasia, Macrophage |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                  +                       +               |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                         3|      2  2.5|
      Hematopoietic Cell Proliferation     |                            4                                             |      2  4.0|
      Capsule, Hemorrhage                  |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +        +  +  +  M     +           +  +  +     +              +     +|  17        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +        +     +  +     +           +  +                              |  14        |
      Hyperplasia, Cystic                  |    2        2     3  2     2           3  3                              |     14  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +  +  +  +  +     +           +  +  +     +     +        +     +|  26        |
      Face, Cyst Epithelial Inclusion      |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Gliosis                              |                                                                          |      1  2.0|
      Hemorrhage                           |                3                          3                              |      2  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                +                                                         |   1        |
      Hemorrhage                           |                3                                                         |      1  3.0|
      Nerve, Demyelination                 |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Alveolar Epithelium, Hyperplasia     |             2                                                            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 6| 5| 7| 3| 7| 7| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 0| 3| 3| 1| 9| 0| 2| 3| 4| 3| 3| 3| 5| 6| 8| 3| 6| 3| 3| 3| 3| 8| 3| 1|            |
                                           | 1| 3| 1| 1| 6| 1| 1| 7| 4| 2| 4| 4| 5| 1| 5| 0| 5| 7| 5| 5| 6| 6| 9| 6| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
      Mucosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +        +  +  +  +     +           +  +  +     +              +     +|  21        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +  +  +  +     +           +  +  +     +        +     +  +  +|  24        |
      Hydronephrosis                       |                                                                   3      |      2  3.0|
      Nephropathy, Chronic                 |    1        3  3  2  3     2           3     3     2        4     2  4  3|     23  2.5|
      Cortex, Cyst                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +        +  +  +  +     +           +  +  +     M              +     +|  20        |
      Hemorrhage                           |                                                                   3      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3|             
                                           | 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +                 +  +  +                             +           +      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               4                                          |             
      Basophilic Focus                     |    2  1  1  1  1     1     2  3  2     2  2  2  2  1     1  1  1  1  1  1|             
      Clear Cell Focus                     |       X                                                                  |             
      Congestion                           |    3                                                                     |             
      Degeneration, Cystic                 |                2           2  4     2     2     2     2                  |             
      Eosinophilic Focus                   |    1  1  1  2  3     1  4  2  4  2  2  2  4  2  1  2  3  2     2     2  2|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hypertrophy                          | 2  1  1  1  1  2  1     2  1  1        1  1  1  1  2     1     1  1      |             
      Inflammation, Chronic, Multifocal    |    2                                   1  1  2  2           2            |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |       1              2                          2                        |             
      Vacuolization Cytoplasmic            | 3  1  2  2  3  2  3  2  3  2  2  2  2  3  2  3  1  2     3  4  2     2  2|             
      Bile Duct, Hyperplasia               | 1  3  3  2  3  3  4  2  4  2  4  3  2  3  4  2  2  2  4  2  3  3  2  3  3|             
      Oval Cell, Hyperplasia               |                         2     3                       2                  |             
      Portal Vein, Thrombosis              |                                                       3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                 +  +  +                             +           +      |             
      Fibrosis                             |                                                       4                  |             
      Inflammation, Chronic Active         |                                                       4                  |             
      Acinus, Atrophy                      |                      1  3                                         2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Acanthosis                           |                                                             3            |             
      Inflammation, Chronic Active         |                                                             3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +                 +  +  +                             +           +      |             
      Degeneration, Chronic                | 3                 2     3                                         2      |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +                 +  +  +                             +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3|             
                                           | 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +                 +  +  +                             +           +      |             
      Hyperplasia                          |                      2  2                                         2      |             
      Necrosis                             |                                                       4                  |             
      Vacuolization Cytoplasmic            | 3                 3  2  2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +                 +  +  +                             +           +      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +           +  +  +  +                          +     +     +      |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                 +  +  +                             +           +      |             
      C-Cell, Hyperplasia                  | 2                 3  2  2                             3           3      |             
      Follicle, Cyst                       |                         X                                                |             
      Follicular Cell, Hypertrophy         |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +                 +  +  +                             +           +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                 +  +  +     +                 +     +        +  +      |             
      Inflammation, Chronic Active         |                   2     2                             3        4         |             
                                            __________________________________________________________________________|             
   Prostate                                | +                 +  +  +                             +           +      |             
      Inflammation, Chronic Active         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                         +           +                                    |             
      Dilatation                           |                                     3                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 2                                                                        |             
      Seminiferous Tubule, Atrophy         |                      3        2                                         3|             
      Seminiferous Tubule, Mineralization  |                               3                                         2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +                 +  +  +                             +           +      |             
      Femoral, Atrophy                     |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                 +  +  +     +                       +           +      |             
      Mediastinal, Hemorrhage              |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                     2              2                     |             
      Hematopoietic Cell Proliferation     |                                                 3                        |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M                 +  +  +                             +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 2| 8| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 1| 3| 3| 3| 7| 3| 3|             
                                           | 6| 7| 7| 7| 7| 8| 3| 1| 1| 8| 8| 8| 9| 9| 9| 9| 9| 0| 7| 0| 0| 0| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    3 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                       4                  |             
      Necrosis                             |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                 +  +  +              +           +  +           +      |             
      Hyperplasia, Cystic                  | 2                 3  3  2                             3           2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +           +  +  +     +        +              +     +  +  +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +                 +  +  +                             +           +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                 +  +  +                             +           +      |             
      Compression                          |                      X                                                   |             
      Hydrocephalus                        |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                 +  +  +  +                          +           +      |             
                                            __________________________________________________________________________|             
   Nose                                    | +                 +  +  +                             +           +      |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                 +  +  +                             +           +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Lens, Cataract                       |                            3                                             |             
      Retina, Atrophy                      |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +              +  +  +  +     +                       +     +     +      |             
      Nephropathy, Chronic                 |                4  2  2  3     4                       2     4     2      |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +                 +  +  +                             +           +      |             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +           +     +  +           +  +  +  +           +            |  16        |
      Parasite Metazoan                    |                                           X                              |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  4.0|
      Basophilic Focus                     | 2        2  2  1     2        1  2  1  1           X  1  1     1  2  1  1|     36  1.4|
      Clear Cell Focus                     |                                                                          |      1     |
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Cystic                 | 2  2              2  2           2                                       |     12  2.2|
      Eosinophilic Focus                   |    1  4  3  2  2  1  2        1  3  2  1  3        2  2  3     2  2  2  2|     40  2.1|
      Hepatodiaphragmatic Nodule           |                                                          X               |      1     |
      Hypertrophy                          | 1  1           1     2     1  1     2  1     2     2  1  2  2  2  1     1|     34  1.3|
      Inflammation, Chronic, Multifocal    |             1                       1                 1  1     2     2  2|     13  1.5|
      Inflammation, Chronic Active         |                               2                                          |      1  2.0|
      Necrosis                             |                                                 2                        |      4  1.8|
      Vacuolization Cytoplasmic            | 2           2     2  3  2  3  2     2  1  3  4     2  2  2  4  2  3  2  3|     42  2.4|
      Bile Duct, Hyperplasia               | 3  4  4  4  3  3  4  3     2  2  2  3  3  4  3  2  3  3  3  3  2  2  3  4|     49  2.9|
      Oval Cell, Hyperplasia               |          3                                                               |      4  2.5|
      Portal Vein, Thrombosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +           +     +  +           +  +  +  +           +            |  16        |
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Acinus, Atrophy                      |    2  2           1     2  3                                             |      8  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           | 3                                            4                           |      3  3.3|
      Inflammation, Chronic Active         | 3                                                                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +           +     +  +           +  +  +  +           +            |  16        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Degeneration, Chronic                |                   3                    3     3  3           2            |      9  2.7|
      Thrombosis                           |    X                                                                     |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +           +     +  +           +  +  +  +                        |  15        |
      Hyperplasia                          |                                           2                              |      4  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic            |    2                                         3  2                        |      7  2.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +           +     +  +           +  +  +  +           +            |  16        |
      Hyperplasia                          |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +        +  +     +  +     +     +  +  +  +           +            |  22        |
      Pars Distalis, Cyst                  |                                                             X            |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +           +     +  +           +  +  +  +           +           +|  17        |
      C-Cell, Hyperplasia                  |    3  3           3     3  3           3  3  3  3           2            |     16  2.8|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hypertrophy         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +           +     +  +           +  +  +  +           +            |  16        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +           +     +  +           +  +  +  +     +     +            |  20        |
      Inflammation, Chronic Active         |    2  2           2     2  3              2  2  2     3     2            |     14  2.4|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +           +     +  +           +  +  +  +           +            |  16        |
      Inflammation, Chronic Active         |                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                +         |   3        |
      Dilatation                           |                                                                3         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |                                                 3     2                  |      5  2.6|
      Seminiferous Tubule, Mineralization  |                                                 2                        |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +           +     +  +           +  +  +  M           +            |  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Femoral, Atrophy                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +           +     +  +           +  +  +  +           +            |  18        |
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                                                             2            |      1  2.0|
      Fibrosis                             | 2              2        2                                            4   |      6  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Necrosis                             |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +           +     +  +           +  +  +  +           +            |  15        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +           +        +              +                 +            |  14        |
      Hyperplasia, Cystic                  |    3  3           3        3              2                 2            |     12  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +           +  +  +  +           +  +  +  +           +            |  22        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +           +     +  +           +  +  +  +           +            |  16        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +           +     +  +           +  +  +  +           +            |  16        |
      Compression                          |                            X                                             |      2     |
      Hydrocephalus                        |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +           +     +  +           +  +  +  +           +            |  17        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +           +     +  +           +  +  +  +           +            |  16        |
      Mucosa, Inflammation, Chronic Active |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +           +     +  +           +  +  +  +           +            |  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +        +                                               +      |   4        |
      Lens, Cataract                       |          3                                                               |      2  3.0|
      Retina, Atrophy                      |          4                                                        2      |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7| 7| 6| 7| 5| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 0| 3| 3| 3| 7| 3| 8| 5| 3| 3| 3| 7| 2| 4| 1| 3| 3| 3| 8| 3| 3| 3| 3|            |
                                           | 1| 0| 2| 1| 1| 4| 9| 4| 2| 4| 4| 4| 5| 6| 1| 5| 6| 5| 5| 5| 7| 6| 6| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    3 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    1-1                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +           +     +  +           +  +  +  +           +            |  20        |
      Nephropathy, Chronic                 | 4  2  3           3     3  4           2  3  3  2           2            |     19  2.8|
      Cortex, Cyst                         |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +           +     +  +           +  +  +  +           +  +         |  17        |
      Calculus Micro Observation Only      |                                                                X         |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3|             
                                           | 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +     +  +     +  +  +        +  +              +           +      |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     +  +     +  +  +        +  +              +           +      |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +  +     +  +  +        +  +                          +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2  1     1        1     1        2  2  2     1  1     1  2  1  1     2  1|             
      Degeneration, Cystic                 |                   2                                2     3               |             
      Eosinophilic Focus                   | 3  3  2  2     4  3     3     3  2  3  X  2  2  2  3     4  4  3  2  4  3|             
      Hypertrophy                          | 1  2  2  3        2           2  2  3     3     2  3        3  2     2  3|             
      Inflammation, Chronic, Multifocal    |       2  2                                2                 2            |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 2        4        2           2  3        4  2  3  4  2  4  4  4     4  4|             
      Bile Duct, Hyperplasia               | 2  3  2  2  4  4  3  4  3  4     2  3  2  3  4  4  3  2  4  3  3  3  3  2|             
      Oval Cell, Hyperplasia               | 2              2                                         2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Inflammation, Chronic Active |                                              4                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     +  +     +  +  +        +  +              +           +      |             
      Acinus, Atrophy                      |       1     2  1     3     1        3  2              2                  |             
      Acinus, Cytomegaly, Focal            |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                3     3                                                   |             
      Cyst Epithelial Inclusion            |                                     X                                    |             
      Inflammation, Chronic Active         |                4     3                                      3            |             
      Ulcer                                |                3                                      4     3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +  +     +  +  +        +  +              +           +      |             
      Degeneration, Chronic                |       3     2  2     3  3  3        3  3                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3|             
                                           | 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +     +  +     +  +  +        +  +              +           +      |             
      Hyperplasia                          |             2  2     2                                            2      |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +     +  +     +  +  +        +  +              +           +      |             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +     +  +  +     +  +  +     +        +        +  +      |             
      Pars Distalis, Hyperplasia           |       2     2                    3                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +  +     +  +  +        +  +              +           +      |             
      C-Cell, Hyperplasia                  |       3     3  3     2  2  2        2  2              2           2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +     +  +  +  +  +  +        +  +  +     +     +        +  M      |             
      Inflammation, Chronic Active         |       3     2  2  3  2  2  2                    4                        |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +     +  +     +  +  +        +  +              +           +      |             
      Inflammation, Chronic Active         |       2                 2  2                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +                    +                                      +      |             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |       +                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                              2                           |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                            3                                             |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       M     +  +     +  +  +        M  +              +           M      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +     +  +  +        +  M              +                 +|             
      Hyperplasia, Cystic                  |                3     2  3  3        2                 2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 6| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 6| 2| 8| 1| 2| 6| 1| 9| 2| 2| 1| 7| 2| 2| 2| 3| 6| 3| 3| 3| 0| 3| 3|             
                                           | 7| 7| 8| 7| 6| 6| 8| 3| 7| 7| 8| 8| 4| 4| 9| 9| 9| 0| 9| 0| 0| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +  +  +  +  +  +        +  +     +        +     +     +      |             
      Acanthosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +  +     +  +  +        +  +              +           +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +  +     +  +  +        +  +  +           +           +      |             
      Hemorrhage                           |             3              2                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +     +  +     +  +  +        +  +              +           +      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +     +  +     +  +  +        +  +              +           +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +     +  +     +  +  +        +  +              +           +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +     +     +        +                           |             
      Lens, Cataract                       |                         3     4     3        3                           |             
      Retina, Atrophy                      |                         4     4     4        4                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +     +  +  +        +  +              +           +      |             
      Nephropathy, Chronic                 | 4  4  3     3  4     3  3  2        4  4              4           2      |             
      Cortex, Cyst                         | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +  +     +  +  +        +  +              +           +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6|            |
                             DAY ON TEST   | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7|            |
                                           | 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  A        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  26        |
      Dilatation                           |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
      Parasite Metazoan                    |                                                 X                        |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  28        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |    1        2  3              2     2  2        1  1     2        2  2  4|     28  1.6|
      Degeneration, Cystic                 |    2           2                                                         |      5  2.2|
      Eosinophilic Focus                   | 2  2  3  3  2  2  2  3  3  2  2  4  2  3     2  4  2  2  3     3  3  4  3|     44  2.7|
      Hypertrophy                          |    3     2  2  2        2              2     2  2  2     2           2  1|     27  2.2|
      Inflammation, Chronic, Multifocal    |                                                                   2     2|      6  2.0|
      Inflammation, Chronic Active         |                                                          2               |      1  2.0|
      Necrosis                             |                                                    2                     |      1  2.0|
      Vacuolization Cytoplasmic            |    3     3  3  2        3  2        2  1        1  2  2  2           2   |     28  2.7|
      Bile Duct, Hyperplasia               | 4  3  4  2  3  2  4  3  3  4  2  3  2  3     3  2  3  4  3  2  4  2  3  2|     48  3.0|
      Oval Cell, Hyperplasia               |             1  1     2           2                    2  2     2     2   |     11  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                        +   |   3        |
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                      3   |      2  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
      Acinus, Atrophy                      |          3           1     4        2              2                     |     13  2.1|
      Acinus, Cytomegaly, Focal            |                                                                2         |      1  2.0|
      Duct, Hyperplasia                    |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |       2                    3        3              3                    4|      7  3.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic Active         |                            3        2                                   3|      6  3.0|
      Ulcer                                |                            2                                            2|      5  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Ulcer                                |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +                        |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6|            |
                             DAY ON TEST   | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7|            |
                                           | 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
      Degeneration, Chronic                | 3     2  3        3  3     3     2  2        2  2  3  3        3  3     3|     23  2.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +     +  +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  29        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +     +  +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  28        |
      Hyperplasia                          |                      2           2                 2           2        2|      9  2.0|
      Hypertrophy                          | 2                                                                        |      1  2.0|
      Vacuolization Cytoplasmic            |                               2  2  2                       3  2        2|      6  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +     +  +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  29        |
      Hyperplasia                          |                                  2  2        3                    2     2|      6  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +        +  +  +  +  +  +  +     I  +  +  +  +     +  +  +     +|  32        |
      Pars Distalis, Hyperplasia           |          2                    2              2     3        1            |      8  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +        +  +     +  +  +  +     M  +  +  +  +  +  +  +  +     +|  28        |
      C-Cell, Hyperplasia                  | 3     2  1        1  2     2  2  2  2        2  2  2  2  2  2  2  3     3|     28  2.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +        +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  28        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +  +  +     +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  32        |
      Inflammation, Chronic Active         | 2     2  2  3     2  2     3  2  2  2     2  2  2  2  2     2  2  2     2|     27  2.2|
      Duct, Dilatation                     |                      3                                                  2|      2  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +        +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  28        |
      Inflammation, Chronic Active         |                               2                    1        1  2        3|      8  1.9|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |                                                       2     2            |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                 +              +  +        +                          +|   9        |
      Angiectasis                          |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 6| 7| 5| 6| 5| 7| 6|            |
                             DAY ON TEST   | 0| 3| 7| 8| 3| 3| 5| 2| 3| 0| 6| 3| 7| 3| 6| 8| 9| 2| 9| 3| 0| 0| 8| 3| 7|            |
                                           | 0| 4| 3| 5| 4| 4| 6| 2| 5| 0| 0| 0| 9| 6| 1| 3| 3| 1| 5| 6| 3| 9| 2| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |          4     2                                      2                  |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                                   3      |      1  3.0|
      Necrosis                             | 2                                                                        |      2  2.5|
      Thrombosis                           |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +        +  +     I  +  +  +     M  M  +  +  +     +  +  +     +|  22        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                 +  +  +  +  +  +  +           +  +  +     +  +  +     +|  23        |
      Hyperplasia, Cystic                  | 3                 3  2     3  3  2  3           2     3     2  3  3     4|     19  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +        +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  31        |
      Acanthosis                           |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +        +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  28        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +        +  +     +  +  +  +     +  +  +  +  +     +  +  +     +|  29        |
      Hemorrhage                           |       2                                                     2            |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +        +  +     +  +  +  +  +  M  +  +  +  +     +  +  +     +|  28        |
      Alveolar Epithelium, Hyperplasia     |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +        +  +     +  +  +  +     M  +  +  +  +     +  +  +     +|  27        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                             +              +|   7        |
      Lens, Cataract                       |                            3                             3              3|      7  3.1|
      Retina, Atrophy                      |                            4                             4              4|      7  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +        +  +     +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  32        |
      Nephropathy, Chronic                 | 4     2  3        3  3     3  3  4  3     3  3  3  4  4  4  2  4  4  4  4|     32  3.3|
      Cortex, Cyst                         |                                                          X               |      2     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +        +  +     +  +  +  +     A  +  +  +  +     +  +  +     +|  27        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3|             
                                           | 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +  +  M     +  +  +  +           +              +  +  +  +   |             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +        +  +  M     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +        +  +  A     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             1  3                    1           1                        |             
      Degeneration, Cystic                 | 2                                2                                      2|             
      Eosinophilic Focus                   | 4     3  4  4  2     4  1  1  4  3  3  3  4  3  3     4  4     2  3  3  4|             
      Hypertrophy                          | 2  2  2  3  3  2     3  2  1  2  2  2  2  2     2  2  2     2        2  2|             
      Inflammation, Chronic, Multifocal    |                      2           2     2                                 |             
      Inflammation, Chronic Active         |                            1                                             |             
      Necrosis                             |                   3                                                      |             
      Vacuolization Cytoplasmic            |          2     2     3  1  1  2     3  4  2  2     2  3              2  3|             
      Bile Duct, Hyperplasia               | 3  4  3  4  3  2  2  4     2  4  3  4  3  2  4  2  3  3  3  3  4  3  2  4|             
      Oval Cell, Hyperplasia               |       2  2  2                       2     2        2     2              2|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +  +     +  +  +  +           +              +  +  +  +   |             
      Acinus, Atrophy                      |                2                                               3         |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +        M  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                            3                                2  3         |             
      Inflammation, Chronic                |                                                                      2   |             
      Inflammation, Chronic Active         |                            3                 3                 3         |             
      Mineralization                       |                   1                                                      |             
      Ulcer                                |                            2                 4                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                                                          |             
      Inflammation, Chronic Active         |                                              2                           |             
      Mineralization                       |                                                          2               |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3|             
                                           | 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Degeneration, Chronic                |    2        2  2  2     2     3  2           3                    2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Degeneration, Cystic                 |                                                                   2      |             
      Hyperplasia                          |    2        2              2                                             |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |             2  2           2  2              2                 2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                             2     2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      C-Cell, Hyperplasia                  |    2        3  1  2     2  2  2              3              2  2  2  3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +        +  +  +     +  +  +              +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Inflammation, Chronic Active         |    2        2     2     2  2  2  2           2                 2     3   |             
      Duct, Dilatation                     |                                                                          |             
      Duct, Hyperplasia, Squamous          |                                                                3  2      |             
                                            __________________________________________________________________________|             
   Prostate                                |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                            2                 2                           |             
      Metaplasia, Squamous                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |    2                    2                                   2            |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +  M  +  +     +  +  +  +           +              +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +     +                       +           +                 +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |                                  +                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 5| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 2| 1| 2| 2| 1| 7| 2| 2| 1| 2| 0| 0| 2| 2| 2| 9| 3| 3| 3| 3| 8| 8| 7| 9| 3|             
                                           | 7| 9| 7| 8| 0| 3| 9| 8| 0| 6| 3| 1| 9| 9| 9| 3| 0| 0| 0| 1| 4| 9| 6| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                         3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +        +  +  +     +  M  +  +           +              +  +  M  I   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +  +  +        +  +  +           +              +        +   |             
      Hyperplasia, Cystic                  |             2  2  2        3  2  2           2              3        3   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Compression                          |                                                                X         |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                2     2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Foreign Body                         |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +              +                                             |             
      Lens, Cataract                       |             3              3                                             |             
      Retina, Atrophy                      |             4              4                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Nephropathy, Chronic                 | 3  3        4  3  2     2  4  3  4           4              3  4  4  4   |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +        +  +  +     +  +  +  +           +              +  +  +  +   |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9|            |
                                           | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  30        |
      Inflammation, Chronic Active         |                                              2                           |      1  2.0|
      Ulcer                                |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Parasite Metazoan                    |                                                                X         |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  30        |
      Parasite Metazoan                    |                                                                   X      |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +           +        +  +  A  +  +        +  +  +  +  +  +  +  +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                  2     1        1                       2|      8  1.5|
      Degeneration, Cystic                 |                                                                          |      3  2.0|
      Eosinophilic Focus                   | 4  1  4  3  X  4  4  2           2  3  3  4  4  1  2  3     2  2  3  3  2|     42  3.0|
      Hypertrophy                          |          2  2     2                    2  2     3     2  2        2      |     29  2.1|
      Inflammation, Chronic, Multifocal    |                                        2                                 |      4  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis                             |                            3                                             |      2  3.0|
      Vacuolization Cytoplasmic            |          3     2  4        2        1  3  3     4  2  2  2  2     3     2|     28  2.4|
      Bile Duct, Hyperplasia               | 4  2  4  3  2  3  3  4  3  2  2  3  4  3  3  4     4  3  2  3  2  3  4   |     47  3.1|
      Oval Cell, Hyperplasia               |          2  2     2  2                    2                              |     13  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
      Acinus, Atrophy                      | 2              4                 2  3        1  1  2  3        2     3   |     12  2.3|
      Acinus, Hyperplasia                  |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                2                                            2     3     3|      7  2.6|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                   3     3|      5  3.0|
      Mineralization                       |                                                                          |      1  1.0|
      Ulcer                                |                                                                         3|      3  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia                            |                                           2                              |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9|            |
                                           | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Degeneration, Chronic                | 2  2           3           2     3  2        2  3        2     2  2  3   |     22  2.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +           +     +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +           +     M  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia                          |                2                                               2         |      5  2.0|
      Necrosis                             |                         2                                                |      1  2.0|
      Vacuolization Cytoplasmic            | 2              2                    2        2        2     2  2  2  2   |     15  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +           +     +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +           +        +  +  +  +  +        +  +  +  +  I  +  +  +  +  +|  30        |
      Pars Distalis, Cyst                  |                                                       X                 X|      2     |
      Pars Distalis, Hyperplasia           |                2        2        3                                   2   |      6  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      C-Cell, Hyperplasia                  | 3  2           3        2  2  2  2  2        3  2  3  3  3  3  2  3  2  3|     30  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +     +  +     +  M  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  34        |
      Inflammation, Chronic Active         | 2  2           2           1  3  2           2     1        2  2  2  2  3|     23  2.0|
      Duct, Dilatation                     |                      3                                                   |      1  3.0|
      Duct, Hyperplasia, Squamous          |                                                          3               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +           +        +  +  +  +  +        +  +  +  +  +  M  +  +  +  +|  30        |
      Inflammation, Acute                  |                                              3                           |      1  3.0|
      Inflammation, Chronic Active         |                2                 4              2                        |      5  2.4|
      Metaplasia, Squamous                 |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                               +                                          |   1        |
      Dilatation                           |                               2                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9|            |
                                           | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |                         2        2                    2  2  2  2         |      9  2.0|
      Seminiferous Tubule, Atrophy         |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +        +     +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +        +                                      +         |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |    2                                                  3                  |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M           +     +  +  M  +  +  +        +  +  +  +  +  M  +  +  M  M|  24        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +                    +  +                    +  +     +  +  +  +  +   |  20        |
      Hyperplasia, Cystic                  | 2  2                    2  2                    2  3     2  3  3  2  2   |     20  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Compression                          |                                                                          |      1     |
      Hemorrhage                           |                               2                    2                     |      2  2.0|
      Hydrocephalus                        |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Foreign Body                         |                                                                         2|      1  2.0|
      Mucosa, Inflammation, Acute          |                                                                         2|      1  2.0|
      Mucosa, Inflammation, Chronic Active |                                     2              2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7| 7| 7| 7| 7| 4| 5| 4| 6| 6| 7| 7| 6| 5| 6| 5| 4| 6| 6| 6| 6| 6|            |
                             DAY ON TEST   | 5| 8| 3| 3| 3| 3| 3| 3| 9| 1| 9| 7| 8| 3| 3| 4| 4| 9| 8| 5| 2| 1| 6| 9| 9|            |
                                           | 7| 3| 4| 4| 4| 0| 5| 5| 1| 7| 2| 6| 5| 6| 6| 5| 9| 1| 2| 5| 6| 8| 8| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     3-3                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                    +              +      |   4        |
      Lens, Cataract                       |                                                    3              3      |      4  3.0|
      Retina, Atrophy                      |                                                    4              4      |      4  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  32        |
      Nephropathy, Chronic                 | 3  3           3        1  3  3  4  3        4  4  3  3  2  3  3  4  4  4|     32  3.3|
      Cortex, Cyst                         |                                                 X                        |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +           +        +  +  +  +  +        +  +  +  +  +  +  +  +  +  +|  31        |
      Inflammation, Acute                  |                                              3                           |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|             
                                           | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +           +  +  +     +        +  +     +  A           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                   2              2        2        1     1  2  1        1|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                2     2              2        2        2                  |             
      Eosinophilic Focus                   | 4  4  4  2  4  3  3  4  3  3  4  3  2  3  3  4  2  2  4  4  3  3  1  3  3|             
      Hypertrophy                          | 3     2  2  2           2     1  2  1     2        2     2     1        2|             
      Inflammation, Chronic                |             2                                                            |             
      Inflammation, Chronic, Multifocal    |                                     2                          1         |             
      Necrosis                             |                                     2                                    |             
      Vacuolization Cytoplasmic            | 3     3  4  3        4  3        3        2        3  2  4  4  2  4  2  3|             
      Bile Duct, Hyperplasia               | 3  4  3  3  3  3  3  2  3  4  3  2  2  2  3  4  4  2  3  3  4  2  3  3  3|             
      Oval Cell, Hyperplasia               |    2  2  2  2  2        2  2           2  1  2        2  2           2   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +     +     +  +  +     +        +  +     +  +           +  +  +  +   |             
      Necrosis                             |                                                                          |             
      Acinus, Atrophy                      |                3           1        1  3                    2  3  2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +           +  +  +     +        +  +     +  M           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                  3                             3     3   |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                  1                                       |             
      Inflammation, Chronic Active         |                                                                3     3   |             
      Ulcer                                |                               4                                3     3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Mineralization                       |                                                                         2|             
      Ulcer                                |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Degeneration, Chronic                |                3  2  3     3        3        2  3           2  2  2  3   |             
      Thrombosis                           |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|             
                                           | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Atrophy                              |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |                                                                2     2   |             
      Hypertrophy                          |                2                                                  2      |             
      Vacuolization Cytoplasmic            |                   2  1                 2                       2  3      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Hyperplasia                          |                      2                                                   |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M           +  +  +     +        +  +     M  +           +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +           +  +  +     +  +     +  +     +  +     +     +  +  +  +   |             
      Pars Distalis, Cyst                  |                                     X                                    |             
      Pars Distalis, Hemorrhage            |                                                             4            |             
      Pars Distalis, Hyperplasia           |    2                                   1                          3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      C-Cell, Hyperplasia                  |    3           3  3  3     2        2  3     2  2           2  3  2  3   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Inflammation, Chronic Active         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +  +  +     +  +     +  +     +  +           +  +  +  +   |             
      Inflammation, Chronic Active         |    2           2           2        2  2     2  2           2  2  2  3   |             
      Duct, Dilatation                     |                               3                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Inflammation, Chronic Active         |                3                    3  1        2                 4      |             
      Metaplasia, Squamous                 |                                        1                          3      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                        2                                 |             
      Seminiferous Tubule, Atrophy         | 3                                                                 4      |             
      Seminiferous Tubule, Mineralization  | 3                                                                 3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|             
                                           | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +           +  +  +     +     +  +  +     +  M           +  +  +  +   |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                      3   |             
      Mediastinal, Congestion              | 4                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +                 +  +                          +         |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |                                     +                          +         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Cyst                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +           +  +  +     M        +  +     +  +           +  +  +  +   |             
      Depletion Lymphoid                   |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +           +     +     +        +  +     +                       +   |             
      Hyperplasia, Cystic                  |    2           3     3     2        2  2     2                       2   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +  +  +     +        +  +  +  +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Compression                          |                      X     X                                X        X   |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                      3     2                                2        3   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Mucosa, Inflammation, Chronic Active |    2                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +           +  +  +     +  +  +  +  +  +  +  +           +  +  +  +   |             
      Nephropathy, Chronic                 |    2           4  2  4     3  4  4  3  2  4  3  4           3  4  3  4   |             
      Cortex, Cyst                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 7| 2| 2| 2| 2| 2| 0| 2| 4| 2| 3| 7| 4| 3| 8| 8| 3| 3| 3| 6| 0| 1| 5| 3|             
                                           | 7| 9| 7| 8| 8| 2| 6| 6| 9| 6| 9| 0| 7| 4| 0| 3| 9| 1| 1| 1| 7| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +           +  +  +     +        +  +     +  +           +  +  +  +   |             
      Hemorrhage                           |                                     4                                    |             
      Mucosa, Hyperplasia                  |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7|            |
                                           | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Ulcer                                |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  29        |
      Parasite Metazoan                    |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | 1     2     2           1        3  1                          1         |     15  1.5|
      Clear Cell Focus                     |       2                                                                  |      1  2.0|
      Degeneration, Cystic                 |                                        2                                2|      7  2.0|
      Eosinophilic Focus                   | 3  3  1  3  4     4  2  2  4  2  2  2  3  3  3  4  3     3  1  3  3     3|     47  3.0|
      Hypertrophy                          | 3  2  1  2  2     2  2     2  1  2  2  2     2                 2         |     27  1.9|
      Inflammation, Chronic                |                                                                2         |      2  2.0|
      Inflammation, Chronic, Multifocal    |                      2           3                                       |      4  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 3  3     2  3     3  2  3  3  2  2  2              2        2  2     2  2|     32  2.7|
      Bile Duct, Hyperplasia               | 4  2  2  4  2     3  2  2  3  3  3  2  3  3  2  3  3  2  4  3  3  3  4  2|     49  2.9|
      Oval Cell, Hyperplasia               | 1           1     2              3     3  2  2  3        2        2      |     23  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +                                       |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
      Necrosis                             |                                                             4            |      1  4.0|
      Acinus, Atrophy                      |       2                 1  4  2           2  1     2  2                 2|     16  2.1|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |       3              3  3  2     3                                       |      8  2.9|
      Erosion                              |                            2                                             |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |       3              3           3                                       |      5  3.0|
      Ulcer                                |       3                                                                  |      4  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                         2|      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7|            |
                                           | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
      Degeneration, Chronic                |       3        3        2     3  2     2  2  3     2  3  2              2|     23  2.5|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +        M     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +        M     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Atrophy                              |                                  3                                       |      1  3.0|
      Degeneration, Cystic                 |                                                 2                        |      1  2.0|
      Hyperplasia                          |                                           2        2                     |      4  2.0|
      Hypertrophy                          |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |       2              2     3  1           2        2  2     2           2|     14  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +        M     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Hyperplasia                          |                                           2  2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Necrosis                             |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  29        |
      Hyperplasia                          |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +        +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  34        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |                               3                       3  2           2  2|      8  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      C-Cell, Hyperplasia                  |       3              3  3     2  3     2  3  2  3  2  3  3  3     3  3  3|     29  2.7|
      Follicle, Cyst                       |                                           X                              |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +        +        +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Inflammation, Chronic Active         |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  32        |
      Inflammation, Chronic Active         |       3              4  2  3  2  2     2  2  2  3     2  2  2        4   |     25  2.3|
      Duct, Dilatation                     |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7|            |
                                           | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
      Inflammation, Chronic Active         |                      2                 1     2  1           2            |     10  2.1|
      Metaplasia, Squamous                 |                                        1                                 |      3  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |                      2                       1        2                  |      4  1.8|
      Seminiferous Tubule, Atrophy         |                                                                   3      |      3  3.3|
      Seminiferous Tubule, Mineralization  |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Femoral, Myelofibrosis               |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +        M     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
      Mandibular, Hyperplasia, Lymphoid    |       4              3                                                   |      3  3.3|
      Mediastinal, Congestion              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Cyst                        |                                                                X         |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +        +     +  M  +  +  M     +  M  +  +  +  +  +  +     +  +  +|  27        |
      Depletion Lymphoid                   |                                                 4                        |      1  4.0|
      Necrosis                             |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +     +     +  +  +     +           +     +  M     +  +  M|  18        |
      Hyperplasia, Cystic                  |                2     2     3  2  2     2           2     3        3  2   |     18  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  32        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
      Compression                          |                                                                          |      4     |
      Hemorrhage                           |                3                                                         |      1  3.0|
      Hydrocephalus                        |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +        +     +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +|  31        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 3| 7| 5| 6| 5| 6| 6| 7| 6| 6| 6| 7| 5| 5| 6| 6| 7| 6| 5| 6|            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 9| 3| 4| 9| 3| 3| 9| 3| 2| 6| 9| 3| 9| 2| 1| 5| 3| 3| 3| 7|            |
                                           | 4| 4| 1| 5| 5| 7| 5| 7| 4| 1| 9| 9| 6| 3| 6| 1| 1| 4| 2| 9| 7| 6| 0| 1| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    10 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     10-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Mucosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +        +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +     +                                                |   3        |
      Cornea, Inflammation, Chronic Active |                         3                                                |      1  3.0|
      Lens, Cataract                       |                   4     3                                                |      2  3.5|
      Retina, Atrophy                      |                   4     4                                                |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  37        |
      Nephropathy, Chronic                 |       4     4        2  4  3  3  4  4  3  3  4  3  3  3  4  2  4  2  3  3|     36  3.3|
      Cortex, Cyst                         |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +        A     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +|  30        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|             
                                           | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Basophilic Focus                     |                2        2                                                |             
      Clear Cell Focus                     |             2                                                            |             
      Degeneration, Cystic                 |          3                                                               |             
      Eosinophilic Focus                   | 4  3  4  4  4  4  3  4  4  4  4  4  4  3  4  4  4  4  4  4  4  3     4  4|             
      Hypertrophy                          |    3  2              2  2     2     2     2                 2           2|             
      Inflammation, Chronic, Multifocal    |                                                 2                       2|             
      Metaplasia                           |                                                                          |             
      Necrosis                             | 3                                                                        |             
      Vacuolization Cytoplasmic            |          1  1  2  2  2  3  2  2  3  3  3  3        2     2  2  1     3   |             
      Bile Duct, Hyperplasia               | 3  4  3  3  4  3  3  2  2  3  2  2  4  3  2  3  3  3  3  3  3  3  2  3  3|             
      Oval Cell, Hyperplasia               | 2  3     2     2     2  2  2        2     2  2  2  2  2     2  2  3  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +        +                          +           +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 4  2     1  2  3  3  3  3     2  1     2  4  2  4  2  3  3     2  3  2   |             
      Acinus, Cytomegaly                   |                   2                                                      |             
      Acinus, Hyperplasia                  |                                              2                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                           4                              |             
      Acanthosis                           |                      4  2        4  3                 3                  |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic Active         |                      3  2        3  3                                3   |             
      Ulcer                                |                         2        3                                   3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                        2                                 |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|             
                                           | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Degeneration, Chronic                | 2     3  2  2  2  2  2  2  2  2  2  3  3  2  3  3  2  3  2  2  2     3  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2              2                                   3           3|             
      Hypertrophy                          |       2           2  1                          2              2         |             
      Necrosis                             |                                                       3                  |             
      Vacuolization Cytoplasmic            | 2                                         2                          2  2|             
      Capsule, Ectopic Tissue              |                                                       X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                     3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       X                  |             
      Hyperplasia                          |                      2                                                   |             
      Hypertrophy                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                3  2           2              2                    2  2  2|             
      Pars Distalis, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                         2                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                             2            |             
      C-Cell, Hyperplasia                  | 2  2  3  3  2  2  2  2  3  2  2  3  2  3  2  2  2  2  2  2  3  2  2  2  3|             
      Follicular Cell, Cytoplasmic         |                                                                          |             
          Alteration                       |                                                                          |             
      Follicular Cell, Hypertrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  2                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Inflammation, Chronic Active         | 2        2     2     2  2     2  2  2  2     2  2     2  1  2  2  2      |             
      Duct, Dilatation                     |    3                                                  3                  |             
      Duct, Hyperplasia, Squamous          |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |       2     2                                                           2|             
      Metaplasia, Squamous                 |       2                                                                 2|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |    2                                                              2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|             
                                           | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Seminiferous Tubule, Atrophy         |       3           4           3  4                                3      |             
      Seminiferous Tubule, Mineralization  |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Mandibular, Hyperplasia, Lymphoid    |                                                 3                        |             
      Mandibular, Inflammation, Chronic,   |                                                                          |             
           Multifocal                      |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                                         +           +      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  2              2                        |             
      Thrombosis, Multiple                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  M  +  +  +  +  +  M  M  +  +  +  +  M  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +|             
      Hyperplasia, Cystic                  |    2  2  2  2  2  1  2     2  2  2  3  2  2  3  2  2  3     3     2  3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                2         |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Chronic Active |                               2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Lens, Cataract                       |                                                             3            |             
      Retina, Atrophy                      |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 7| 6| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 2| 4| 3| 2| 0| 2| 2| 9| 2| 8| 4| 2| 2| 2| 2| 3| 2| 3| 3| 3| 2| 0| 3|             
                                           | 9| 6| 7| 3| 1| 7| 4| 7| 8| 3| 8| 2| 3| 9| 9| 9| 9| 0| 5| 0| 1| 1| 3| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                 2                        |             
      Nephropathy, Chronic                 | 2  4  3  2  2  3  2  3  4  4  3  4  4  3  3  3  3  3  3  3  2  3  3  4  3|             
      Cortex, Cyst                         |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3|            |
                                           | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |             X                                                            |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |          2           X  2              2        2           2            |      8  2.0|
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Eosinophilic Focus                   | 4        4  4  4  4  3  4  3  3  4     4  3  4  4  3  2  4  3  3  4  4  4|     46  3.7|
      Hypertrophy                          | 3  2  3        2           2        3     2                 1            |     17  2.2|
      Inflammation, Chronic, Multifocal    |    2                                         2                           |      4  2.0|
      Metaplasia                           |                                                                      1   |      1  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |    2     3     3  2  2  2  1     2  4  2  2  3  2  2     3  2     2      |     34  2.2|
      Bile Duct, Hyperplasia               | 3  3  4  3  3  2  2  2  3  3  3  2     3  3  3  3  4  2  2  2  3  3  2  3|     49  2.8|
      Oval Cell, Hyperplasia               | 3  2  3     2  2  2  2  2  1     3     2  3  2  2           1  2  2  4  3|     37  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |    2  3  3  2  2  2     3           2  2     2  3     2  3     2     2   |     35  2.5|
      Acinus, Cytomegaly                   |                                                                          |      1  2.0|
      Acinus, Hyperplasia                  |          3                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis, Focal                    |                                                                          |      1  4.0|
      Acanthosis                           |       3  3           3                    3              2        3      |     11  3.0|
      Cyst Epithelial Inclusion            |                               X                                          |      1     |
      Inflammation, Chronic Active         |          3                                3              2        3      |      9  2.8|
      Ulcer                                |          3                                               2        2      |      6  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 102                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3|            |
                                           | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Chronic                | 2  2        2  3  2  1  2  2  3     2  2  2  2     2        2     2     3|     40  2.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2  2     2     2  3        3        2  2  2  2  2           2      |     17  2.2|
      Hypertrophy                          |                                                    2              2      |      7  1.9|
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |             2                    2  4     3  2        2                  |     10  2.3|
      Capsule, Ectopic Tissue              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2                                                              2      |      4  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |                                  2                                       |      2  2.0|
      Hypertrophy                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           |       3                                                  2        3      |     10  2.3|
      Pars Distalis, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 2  3  2  2  3     2  2  2        2  2  3  2  2  3  3  3  2  2  3  2  2  3|     47  2.3|
      Follicular Cell, Cytoplasmic         |                                                                          |            |
          Alteration                       |                                                                      2   |      1  2.0|
      Follicular Cell, Hypertrophy         |                                                                      1   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |    2                                                                     |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 103                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3|            |
                                           | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Inflammation, Chronic Active         | 2  2  2  2     2  2  2           2     2  2  2     2  2     2  2  2  2  3|     34  2.0|
      Duct, Dilatation                     | 2                                                                        |      3  2.7|
      Duct, Hyperplasia, Squamous          |                                     3                                   3|      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Dilatation                           |                                     3                                    |      1  3.0|
      Inflammation, Chronic Active         |          2           3              2              2                     |      7  2.1|
      Metaplasia, Squamous                 |          2                                                               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |                         1  2        2                 2     2            |      7  1.9|
      Seminiferous Tubule, Atrophy         |                                     3                                    |      6  3.3|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Mandibular, Inflammation, Chronic,   |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                    +                     |   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |       3           2  2        3  2  2              2        2            |     10  2.2|
      Thrombosis, Multiple                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +        +     +  +     +        +  +  +     +  +  +  +  +|  39        |
      Hyperplasia, Cystic                  | 2  2  3  3  3           3     2  3     2        2  3  3     2  3  2  2  2|     37  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrocephalus                        |                                                                         4|      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 7| 7| 7| 6| 7| 5| 5| 7| 4| 7| 6| 7| 7| 6| 5| 6| 7| 6| 6| 7| 7|            |
                             DAY ON TEST   | 1| 3| 9| 0| 3| 3| 3| 8| 0| 8| 3| 3| 9| 3| 9| 1| 3| 8| 1| 6| 3| 6| 0| 3| 3|            |
                                           | 9| 4| 9| 0| 4| 4| 3| 3| 7| 8| 6| 5| 3| 5| 2| 3| 5| 2| 7| 1| 6| 1| 5| 6| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    30 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     0-10                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                      2  3        2                                       |      4  2.3|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                2           3                                             |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mucosa, Inflammation, Chronic Active |                         2                    1                           |      3  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +              +        +        +                  |   5        |
      Cornea, Inflammation, Chronic Active |                                     4                                    |      1  4.0|
      Lens, Cataract                       |                      3                       3                           |      3  3.0|
      Retina, Atrophy                      |                      4                       4                           |      3  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 2  3  3  4  3  3  2  4  4  3  1  3  3  4  4  4  3  3  2  3  4  3  3  3  3|     50  3.1|
      Cortex, Cyst                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 105                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                2              1              2              1            |             
      Clear Cell Focus                     |                                  X                                       |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |       2  2                       2                                       |             
      Eosinophilic Focus                   | 4  4  4  4  4  4  3  4  3  4  4  4     4  4  4  4  4  4  3  4  4  4  4  3|             
      Fibrosis                             |          3                                                               |             
      Hypertrophy                          |                2     1  3     2  2     2     2  2           2     2  1   |             
      Infarct                              |                                     3                                    |             
      Inflammation, Chronic, Multifocal    |                2     1        1                                          |             
      Metaplasia                           |                                                                          |             
      Necrosis                             |                   3           1                                          |             
      Vacuolization Cytoplasmic            | 2  2  2     2  2  1  1  2  3  2  2     2  1  2  3  2  1        2  2  2   |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 3  3  4  4  4  3  3  3  2  3  3  3  3  4  4  3  3  3  3  4  3  4  3  3  4|             
      Oval Cell, Hyperplasia               | 2  2  2  3  3  1  2  2     2     2     2  4  2  2  2  2  3  2  2  3  1  3|             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 4  2     2  4     3  4                       2  2     3  2     2  2  2  2|             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                 3                        |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                         2  3                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Degeneration, Chronic                | 2  2  2  2  3  2  2  3  3  2     3  2  3  2     3  2  2     2     2  2   |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Spindle Cell, Hyperplasia   |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2  3                 2                 2              2  2  2   |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic            | 2        2        2        2  2  2     2     2     2     2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2           2                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                          2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                2                          2                       1  2  3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2  1  2  3  3  3  2  2  2  1  1  2  2  3  2  3  3  3  2  3  3  3  3  3|             
      Follicle, Cyst                       |                                                                         X|             
      Follicle, Hyperplasia, Cystic        |                3                                                         |             
      Follicular Cell, Hyperplasia         |                               2                                          |             
      Follicular Cell, Hypertrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    3                                               2                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  1  2  2  2  3     3  2  3     2  3  2  2  2  3        2  2     2      |             
      Duct, Dilatation                     |       3                                               3     3  3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2  2     2     2              2           2                              |             
      Metaplasia, Squamous                 |    2     3     2              2           2                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |    2              2     2           2                                    |             
      Seminiferous Tubule, Atrophy         |    4  2  4        1     4  3  2                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Neutrophil     |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 6| 7| 7| 6| 7| 6| 6| 4| 7| 4| 5| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 5| 7| 8| 2| 2| 4| 2| 9| 9| 5| 2| 6| 8| 3| 2| 3| 3| 3| 7| 3| 3| 3| 3| 5|             
                                           | 7| 1| 2| 4| 7| 8| 4| 8| 6| 6| 0| 9| 1| 1| 7| 9| 0| 0| 0| 5| 1| 1| 1| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     10-10                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sinus, Mandibular, Ectasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                                                           +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                2  2      |             
      Hematopoietic Cell Proliferation     |                   3                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  M  +  +  +  M  M  +  M  I  +  +  +  M  M  M  +  +  +  +  M  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +     +           +     +  +  +  +           +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  2     2     2           2     2  2  2  2           2  2  2  1  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                 3                        |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                 3                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Subacute                 |                                                                          |             
      Mucosa, Inflammation, Chronic Active |          3  2           2                                2  2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                   +                                +|             
      Lens, Cataract                       |    3                                                                     |             
      Retina, Atrophy                      |    4                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Acinus, Atrophy                      |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  2  2  3  4  3  3  4  2  2  3  2  3  2  2  2  3  3  3  3  3  3  4  3  3|             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05077-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                         POLYBROMINATED BIPHENYL MIXTURE (FIREMASTER FF-1)                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 10:20:16  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 5| 6| 7| 5| 6| 5| 7| 7| 5| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 4| 6| 7|            |
                             DAY ON TEST   | 8| 7| 3| 9| 9| 3| 8| 4| 1| 3| 2| 3| 2| 0| 1| 0| 0| 7| 0| 3| 4| 9| 6| 6| 3|            |
                                           | 6| 4| 5| 6| 5| 5| 1| 2| 5| 5| 9| 4| 6| 3| 8| 5| 5| 9| 8| 6| 3| 5| 2| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|