TDMS Study 05079-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TALC
NTP Experiment-Test: 05079-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 14807966
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 39 50 40 50 40
Scheduled Sacrifice 30 30 29
Early Deaths
Natural Death 17 7 21 5 21 10
Moribund Sacrifice 2 2 4 5 4 1
Survivors
Terminal Sacrifice 30 23 25
Missing 1 1
Culled 1
Animals Examined Microscopically 46 11 49 12 50 12
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (35) (11) (30) (12) (34) (12)
Hyperplasia, Lymphoid 1 (3%)
Serosa, Inflammation, Suppurative 1 (3%)
Intestine Large, Colon (38) (11) (34) (12) (32) (12)
Serosa, Inflammation, Suppurative 2 (6%)
Intestine Small, Duodenum (27) (11) (26) (12) (27) (12)
Ulcer, Focal 1 (4%)
Mucosa, Atrophy 2 (7%) 6 (23%) 4 (15%)
Serosa, Inflammation, Suppurative 2 (8%)
Intestine Small, Ileum (33) (11) (28) (12) (31) (12)
Hyperplasia, Lymphoid 1 (3%) 1 (4%)
Mucosa, Atrophy 4 (12%) 6 (21%) 6 (19%)
Peyer's Patch, Necrosis 1 (3%)
Serosa, Inflammation, Suppurative 2 (7%) 1 (3%)
Intestine Small, Jejunum (33) (11) (29) (12) (31) (12)
Mucosa, Atrophy 2 (6%) 7 (24%) 3 (10%)
Serosa, Inflammation, Suppurative 2 (7%) 1 (3%)
Liver (46) (11) (47) (12) (50) (12)
Clear Cell Focus 1 (9%)
Eosinophilic Focus 1 (2%)
Fibrosis, Focal 1 (2%)
Focal Cellular Change 2 (4%) 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 2 (4%) 1 (8%)
Inflammation, Focal 1 (2%) 1 (9%) 2 (4%) 1 (8%) 1 (2%)
Necrosis, Focal 1 (2%) 2 (4%) 2 (4%)
Pigmentation, Focal, Hemosiderin 1 (2%)
Centrilobular, Degeneration 1 (2%)
Centrilobular, Necrosis, Coagulative 1 (2%)
Serosa, Inflammation, Suppurative 4 (9%) 7 (15%) 5 (10%)
Sinusoid, Inflammation 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (42) (11) (40) (11) (44) (12)
Inflammation, Focal 2 (5%)
Acinus, Hyperplasia, Focal 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%) 5 (13%) 4 (9%)
Salivary Glands (46) (11) (49) (12) (50) (12)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 1 (9%) 2 (17%)
Duct, Hyperplasia 1 (9%)
Stomach (45) (11) (46) (12) (50) (12)
Serosa, Inflammation, Granulomatous 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%) 2 (4%) 1 (2%)
Stomach, Forestomach (45) (11) (46) (12) (50) (12)
Hyperplasia, Focal, Mast Cell 1 (2%)
Hyperplasia, Focal, Squamous 2 (4%) 4 (9%) 1 (8%) 2 (4%)
Ulcer, Focal 1 (2%) 3 (7%)
Glandular, Inflammation, Focal 1 (2%) 2 (4%)
Stomach, Glandular (45) (10) (40) (12) (46) (12)
Inflammation, Suppurative 1 (2%)
Ulcer, Focal 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (46) (11) (49) (11) (50) (12)
Myocardium, Degeneration, Focal 1 (2%)
Myocardium, Inflammation, Focal 1 (2%)
Myocardium, Mineralization, Focal 1 (2%)
Pericardium, Inflammation, Suppurative 1 (2%) 2 (4%) 4 (8%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (46) (11) (46) (12) (50) (12)
Capsule, Inflammation, Suppurative 4 (9%) 7 (15%) 5 (10%)
Corticomedullary Junction, Hemorrhage 2 (4%) 3 (7%) 1 (2%)
Spindle Cell, Hyperplasia 46 (100%) 4 (36%) 46 (100%) 4 (33%) 47 (94%) 4 (33%)
Adrenal Gland, Cortex (46) (11) (45) (11) (50) (12)
Cyst 2 (4%) 3 (7%)
Inflammation, Focal, Suppurative 1 (2%)
Vacuolization Cytoplasmic, Focal 3 (7%)
Adrenal Gland, Medulla (41) (10) (44) (10) (45) (11)
Hyperplasia, Focal 2 (5%)
Parathyroid Gland (23) (5) (19) (3) (25) (8)
Hyperplasia 1 (4%)
Pituitary Gland (42) (10) (43) (8) (48) (12)
Cyst 2 (5%)
Hemorrhage, Focal 2 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia, Focal 2 (5%)
Pigmentation, Lipofuscin 1 (2%)
Thyroid Gland (43) (9) (48) (9) (49) (11)
Cyst 2 (5%)
Inflammation, Acute, Focal 2 (4%)
C-Cell, Hyperplasia 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 9 (21%) 12 (25%) 10 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4) (3) (1) (4) (2) (4)
Thrombosis, Chronic 1 (25%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (38) (11) (43) (11) (46) (12)
Abscess 4 (11%) 10 (23%) 7 (15%)
Cyst 6 (16%) 11 (26%) 10 (22%)
Thrombosis 1 (3%) 2 (5%)
Uterus (44) (11) (46) (12) (49) (12)
Angiectasis 1 (2%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Metaplasia, Squamous 1 (2%)
Thrombosis 1 (2%)
Endometrium, Cyst 1 (8%)
Endometrium, Hyperplasia, Cystic 34 (77%) 4 (36%) 30 (65%) 5 (42%) 35 (71%) 5 (42%)
Mucosa, Inflammation, Suppurative 3 (7%) 7 (15%) 4 (8%) 1 (8%)
Serosa, Inflammation, Suppurative 1 (2%) 4 (9%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (41) (11) (44) (12) (45) (11)
Hyperplasia 1 (2%) 4 (9%) 5 (11%)
Myelofibrosis 28 (68%) 23 (52%) 2 (17%) 27 (60%) 1 (9%)
Myeloid Cell, Hyperplasia 1 (2%) 6 (14%) 3 (7%) 1 (9%)
Lymph Node (46) (11) (47) (12) (49) (12)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Iliac, Inflammation 1 (2%) 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Pancreatic, Infiltration Cellular, Mixed Cell 1 (2%)
Pancreatic, Follicular, Necrosis 1 (2%)
Renal, Hyperplasia, Lymphoid 2 (4%) 2 (4%)
Renal, Infiltration Cellular, Mixed Cell 1 (2%)
Renal, Inflammation 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Follicular, Necrosis 2 (4%) 1 (2%)
Lymph Node, Bronchial (38) (9) (37) (6) (43) (11)
Hyperplasia, Histiocytic 25 (68%) 2 (33%) 39 (91%) 8 (73%)
Hyperplasia, Lymphoid 16 (43%) 20 (47%)
Infiltration Cellular, Mixed Cell 1 (3%)
Inflammation, Acute 1 (3%) 1 (3%) 1 (2%)
Lymph Node, Mandibular (35) (7) (38) (11) (36) (11)
Cyst 1 (3%)
Depletion Lymphoid 1 (3%)
Hyperplasia, Histiocytic 1 (3%) 1 (9%)
Hyperplasia, Lymphoid 1 (3%) 3 (8%) 1 (9%)
Hyperplasia, Plasma Cell 1 (3%) 1 (9%)
Infiltration Cellular, Mixed Cell 1 (3%)
Inflammation 1 (3%) 1 (3%)
Follicular, Necrosis 1 (3%)
Lymph Node, Mediastinal (13) (5) (17) (5) (14)
Hyperplasia, Histiocytic 1 (8%) 3 (18%) 2 (14%)
Hyperplasia, Lymphoid 1 (6%) 2 (14%)
Infiltration Cellular, Mixed Cell 1 (8%)
Lymph Node, Mesenteric (35) (11) (32) (11) (37) (10)
Depletion Lymphoid 1 (3%) 2 (5%)
Hematocyst 1 (3%)
Hyperplasia, Histiocytic 1 (3%) 1 (9%) 1 (3%) 1 (10%)
Hyperplasia, Lymphoid 2 (6%) 2 (5%)
Hyperplasia, Plasma Cell 1 (3%)
Infiltration Cellular, Mixed Cell 5 (14%) 5 (16%) 5 (14%)
Inflammation 2 (6%) 1 (3%)
Follicular, Necrosis 3 (9%) 12 (38%) 7 (19%)
Spleen (45) (11) (45) (12) (50) (12)
Congestion 2 (4%)
Hematopoietic Cell Proliferation 8 (18%) 12 (27%) 10 (20%) 1 (8%)
Hyperplasia, Lymphoid 5 (11%) 8 (18%) 6 (12%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Capsule, Inflammation, Suppurative 2 (4%) 3 (7%) 3 (6%)
Lymphoid Follicle, Depletion Lymphoid 2 (4%) 3 (7%) 5 (10%)
Lymphoid Follicle, Necrosis 2 (4%) 4 (9%) 2 (4%)
Thymus (40) (11) (41) (12) (41) (12)
Cyst 2 (5%) 2 (5%)
Hyperplasia, Plasma Cell 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Necrosis 3 (8%) 5 (12%)
Cortex, Depletion Lymphoid 8 (20%) 1 (9%) 12 (29%) 15 (37%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (41) (10) (45) (12) (48) (12)
Abscess 1 (2%)
Edema 1 (2%)
Skin (46) (11) (47) (12) (50) (12)
Alopecia 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (46) (11) (49) (12) (50) (12)
Periosteum, Femur, Proliferation Connective
Tissue 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (46) (11) (49) (12) (50) (12)
Hydrocephalus 2 (4%)
Mineralization, Focal 36 (78%) 5 (45%) 33 (67%) 6 (50%) 29 (58%) 4 (33%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (42) (11) (44) (12) (48) (12)
Inflammation, Acute 1 (2%)
Lung (46) (11) (49) (12) (50) (12)
Congestion 1 (2%) 3 (6%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Macrophage 2 (4%) 45 (92%) 8 (67%) 43 (86%) 12 (100%)
Inflammation, Chronic Active 25 (51%) 38 (76%) 1 (8%)
Metaplasia, Focal, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Perivascular, Inflammation, Suppurative 3 (6%) 1 (2%)
Pleura, Inflammation, Suppurative 1 (2%) 2 (4%) 5 (10%)
Nose (46) (11) (47) (12) (50) (12)
Cytoplasmic Alteration 2 (17%)
Cytoplasmic Alteration, Focal 29 (63%) 37 (79%) 5 (42%) 40 (80%) 8 (67%)
Developmental Malformation 1 (2%)
Erosion, Focal 3 (7%) 1 (2%)
Inflammation, Acute 6 (13%) 4 (9%) 5 (10%)
Ulcer, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Inflammation, Suppurative 1 (100%)
Harderian Gland (2) (2) (1)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (46) (11) (47) (12) (50) (12)
Casts Protein 2 (4%)
Infarct 1 (2%) 1 (2%)
Inflammation, Focal 1 (2%) 3 (27%) 1 (2%) 1 (8%) 1 (2%)
Metaplasia, Focal, Osseous 1 (2%) 2 (4%)
Nephropathy, Chronic 1 (2%) 1 (2%)
Capsule, Inflammation, Suppurative 3 (7%) 6 (13%) 5 (10%)
Renal Tubule, Hyperplasia, Focal 1 (2%)
Urinary Bladder (44) (11) (41) (12) (41) (12)
Serosa, Inflammation, Suppurative 3 (7%) 3 (7%)
Submucosa, Hyperplasia, Lymphoid 1 (2%)
Submucosa, Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 49 39 49 40 50 40
Scheduled Sacrifice 35 33 31
Early Deaths
Natural Death 16 4 18 5 14 7
Moribund Sacrifice 1 2 1 3 1
Survivors
Terminal Sacrifice 30 28 32
Missing 1
Animals Examined Microscopically 46 12 47 12 49 12
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (31) (12) (29) (11) (35) (11)
Dilatation 1 (3%)
Epithelium, Hyperplasia, Papillary 1 (3%)
Intestine Large, Cecum (34) (12) (35) (12) (37) (12)
Hyperplasia, Lymphoid 1 (3%) 3 (8%)
Intestine Large, Colon (36) (12) (38) (12) (39) (12)
Hyperplasia, Lymphoid 1 (3%)
Intestine Large, Rectum (32) (10) (32) (12) (31) (10)
Serosa, Inflammation, Suppurative 1 (3%)
Intestine Small, Duodenum (32) (12) (30) (12) (34) (12)
Hyperplasia, Lymphoid 1 (3%)
Mucosa, Atrophy 3 (9%) 7 (23%) 3 (9%)
Intestine Small, Ileum (33) (12) (32) (11) (35) (12)
Hyperplasia, Lymphoid 5 (15%) 3 (9%) 5 (14%)
Mucosa, Atrophy 3 (9%) 5 (16%) 4 (11%)
Peyer's Patch, Necrosis 1 (3%)
Intestine Small, Jejunum (32) (12) (31) (12) (36) (12)
Hyperplasia, Lymphoid 1 (3%)
Mucosa, Atrophy 3 (9%) 3 (10%) 2 (6%)
Liver (45) (12) (47) (12) (48) (12)
Abscess 1 (2%) 1 (2%)
Focal Cellular Change 4 (9%) 3 (6%) 5 (10%) 1 (8%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 2 (4%)
Infarct 2 (4%)
Inflammation, Focal 3 (6%) 1 (2%)
Mineralization, Focal 1 (2%)
Necrosis, Focal 4 (9%) 5 (11%) 4 (8%)
Pigmentation, Focal, Hemosiderin 1 (2%)
Bile Duct, Hyperplasia, Focal 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (42) (12) (39) (12) (42) (12)
Serosa, Inflammation, Suppurative 1 (2%)
Salivary Glands (45) (12) (46) (12) (47) (12)
Inflammation, Chronic 1 (8%)
Stomach, Forestomach (43) (12) (41) (12) (46) (12)
Hyperplasia, Focal, Squamous 1 (2%) 1 (2%)
Tooth (3)
Dysplasia 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (45) (12) (46) (12) (49) (12)
Thrombosis 1 (2%) 1 (2%)
Coronary Artery, Mineralization 1 (2%)
Myocardium, Degeneration, Focal 1 (2%)
Myocardium, Fibrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (43) (12) (46) (10) (47) (12)
Spindle Cell, Hyperplasia 38 (88%) 37 (80%) 2 (20%) 35 (74%) 2 (17%)
Adrenal Gland, Cortex (43) (11) (46) (10) (47) (11)
Atrophy 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (10%)
Vacuolization Cytoplasmic, Focal 3 (7%) 4 (9%)
Parathyroid Gland (25) (6) (21) (6) (26) (4)
Cyst 3 (12%) 1 (5%)
Pituitary Gland (44) (11) (44) (9) (46) (11)
Cyst 1 (2%) 1 (2%)
Pigmentation, Lipofuscin 1 (2%)
Thyroid Gland (45) (11) (46) (12) (45) (11)
Cyst 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 4 (9%) 8 (17%) 8 (18%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (39) (12) (39) (12) (42) (12)
Inflammation, Suppurative 1 (3%) 1 (3%)
Preputial Gland (8) (6) (8)
Dilatation 7 (88%) 6 (100%) 8 (100%)
Inflammation 3 (38%) 1 (13%)
Prostate (40) (12) (43) (12) (44) (12)
Inflammation, Suppurative 3 (8%) 7 (16%) 4 (9%)
Epithelium, Hyperplasia 1 (2%)
Seminal Vesicle (41) (8) (43) (8) (39) (8)
Inflammation, Suppurative 2 (5%) 1 (3%)
Testes (43) (12) (44) (12) (45) (12)
Aspermatogenesis, Diffuse 1 (2%)
Atrophy, Diffuse 1 (2%)
Hypospermia 1 (2%) 2 (5%)
Inflammation, Suppurative 1 (2%)
Seminiferous Tubule, Degeneration, Focal 3 (7%) 4 (9%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (40) (12) (42) (12) (43) (12)
Hyperplasia 4 (10%) 1 (2%) 1 (2%)
Myelofibrosis 2 (5%) 2 (5%) 1 (8%)
Myeloid Cell, Hyperplasia 4 (10%) 7 (17%) 1 (2%)
Lymph Node (45) (12) (46) (12) (48) (12)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Plasma Cell 1 (2%)
Lumbar, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lumbar, Hyperplasia, Plasma Cell 1 (2%)
Pancreatic, Inflammation, Granulomatous 1 (2%)
Renal, Depletion Lymphoid 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Bronchial (32) (9) (39) (9) (44) (10)
Abscess 1 (2%)
Hyperplasia, Histiocytic 1 (3%) 32 (82%) 4 (44%) 42 (95%) 7 (70%)
Hyperplasia, Histiocytic, Lymphoid 1 (3%)
Hyperplasia, Lymphoid 3 (9%) 10 (26%) 23 (52%)
Infiltration Cellular, Mixed Cell 3 (9%) 1 (3%) 3 (7%)
Inflammation, Acute 1 (3%)
Follicular, Necrosis 1 (3%)
Lymph Node, Mandibular (23) (6) (23) (9) (19) (4)
Hyperplasia, Histiocytic 1 (4%) 1 (11%)
Hyperplasia, Lymphoid 1 (17%) 1 (11%) 1 (5%)
Follicular, Necrosis 1 (5%)
Lymph Node, Mediastinal (9) (5) (10) (4) (7) (3)
Hyperplasia, Histiocytic 1 (11%) 1 (10%) 2 (29%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 2 (20%)
Lymph Node, Mesenteric (36) (10) (39) (9) (40) (10)
Depletion Lymphoid 1 (3%) 2 (5%)
Hyperplasia, Histiocytic 2 (22%)
Hyperplasia, Lymphoid 4 (11%) 1 (10%) 3 (8%) 6 (15%) 1 (10%)
Infiltration Cellular, Mixed Cell 18 (50%) 20 (51%) 13 (33%)
Inflammation, Granulomatous 1 (3%)
Thrombosis 1 (3%)
Follicular, Necrosis 6 (15%) 2 (5%)
Spleen (44) (12) (44) (12) (47) (11)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 6 (14%) 7 (16%) 10 (21%)
Hyperplasia, Lymphoid 3 (7%) 2 (5%) 1 (8%) 3 (6%)
Hyperplasia, Mast Cell 1 (2%)
Inflammation, Granulomatous 1 (2%)
Lymphoid Follicle, Depletion Lymphoid 2 (5%) 5 (11%)
Lymphoid Follicle, Necrosis 2 (5%) 5 (11%) 1 (2%)
Thymus (34) (11) (33) (11) (40) (12)
Cyst 3 (9%) 2 (6%) 1 (3%)
Hyperplasia, Lymphoid 1 (3%)
Inflammation, Granulomatous 1 (3%)
Necrosis 1 (3%) 2 (5%)
Cortex, Depletion Lymphoid 6 (18%) 10 (30%) 8 (20%)
Epithelial Cell, Hyperplasia, Focal 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (44) (12) (45) (12) (48) (12)
Abscess 1 (2%)
Alopecia 1 (2%) 1 (2%)
Inflammation, Acute 2 (4%)
Ulcer, Focal 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (46) (12) (47) (12) (49) (12)
Rib, Cartilage, Fracture Healed 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (46) (12) (47) (12) (48) (12)
Mineralization, Focal 37 (80%) 5 (42%) 39 (83%) 2 (17%) 38 (79%) 5 (42%)
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a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:51
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B6C3F1 MICE MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
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RESPIRATORY SYSTEM
Larynx (42) (12) (41) (12) (46) (12)
Inflammation, Acute 1 (2%) 1 (2%)
Lung (45) (12) (47) (12) (48) (12)
Congestion 3 (7%) 1 (2%) 1 (2%)
Hyperplasia, Macrophage 3 (7%) 46 (98%) 11 (92%) 48 (100%) 12 (100%)
Inflammation, Chronic Active 16 (34%) 40 (83%) 5 (42%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Alveolus, Mineralization, Focal 1 (8%)
Peribronchiolar, Inflammation, Chronic Active 1 (2%)
Perivascular, Inflammation, Suppurative 1 (2%)
Nose (45) (12) (46) (12) (47) (12)
Cytoplasmic Alteration 1 (8%)
Cytoplasmic Alteration, Focal 5 (11%) 23 (50%) 2 (17%) 40 (85%) 6 (50%)
Erosion, Focal 1 (2%) 1 (2%) 2 (4%)
Inflammation, Acute 4 (9%) 4 (9%) 7 (15%)
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SPECIAL SENSES SYSTEM
Ear (1)
Inflammation, Granulomatous 1 (100%)
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URINARY SYSTEM
Kidney (45) (12) (46) (12) (48) (12)
Casts Protein 1 (2%)
Cyst 2 (4%)
Hydronephrosis 3 (7%) 1 (2%)
Inflammation, Chronic Active, Focal 1 (8%) 1 (8%)
Inflammation, Focal, Suppurative 3 (7%) 5 (11%) 3 (6%)
Metaplasia, Focal, Osseous 3 (7%)
Nephropathy, Chronic 3 (7%) 2 (4%)
Capsule, Inflammation, Suppurative 1 (2%)
Cortex, Cyst 1 (8%)
Pelvis, Inflammation, Suppurative 2 (4%) 5 (11%) 1 (2%)
Urinary Bladder (43) (12) (38) (12) (43) (12)
Dysplasia, Focal 1 (2%)
Inflammation, Chronic Active 6 (14%) 5 (13%) 2 (5%)
Ulcer, Focal 1 (2%)
Lumen, Calculus Micro Observation Only 1 (8%)
Transitional Epithelium, Hyperplasia 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
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