TDMS Study 05079-02 Pathology Tables
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 Facility: Lovelace Inhalation Toxicology Research Institute Chemical CAS #: 14807966 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3| | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7| CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + M + + + + + + + + + M + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Gallbladder | M + + A + + + + + + + A + M + + + I + A + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large | A + + + + + + + + + + A + A + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + A + + + + + + A A + A + + + + + A + +| __________________________________________________________________________| Intestine Large, Colon | A + M + + + + + + + + A + A + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | M + + + + + M + + + + M + A + + + + + + + +| __________________________________________________________________________| Intestine Small | A + + A + + + + + + + A + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + A + + M + M M A A M A + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + A + + + + + + A A + A + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Intestine Small, Jejunum | A + + A + + + + + + + A + A + + + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | __________________________________________________________________________| Mesentery | + | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + A + A + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3| | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7| CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Lymphoma Malignant Undifferentiated | | Cell Type | X | Spindle Cell, Adenoma | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + M + + + + + + + M + + + + + + + + + +| Pheochromocytoma Malignant | | __________________________________________________________________________| Islets, Pancreatic | + + + M + + + + + + + A M A + I + I + + I I| __________________________________________________________________________| Parathyroid Gland | M M M M I M + + + + + + + + M + + M + + I +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M + M + + + + + + + +| Adenoma | X X | __________________________________________________________________________| Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Fibrosarcoma | X | Hemangioma | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + I + I + + + M + + + M + + +| Adenocarcinoma, Metastatic, Uterus | X | Adenoma | | Luteoma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + A A + A + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| Axillary, Lymphoma Malignant Mixed | | Iliac, Lymphoma Malignant Mixed | | Iliac, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3| | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7| CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Undifferentiated Cell Type | X | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + M I + M + + M + + + + + + + I| Adenocarcinoma, Metastatic, Uterus | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + M M + + M + + + + + + M M + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | __________________________________________________________________________| Lymph Node, Mediastinal | M M M + + M + M + M M M M M M M + M M + M M| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Lymph Node, Mesenteric | M + M + + + + M + + M M + M + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + A + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + I + + A + + I + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3| | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7| CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + I + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + A + + + + + + + M + A + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| | DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| | | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A | CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + M + +| 43 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Gallbladder | + A + A + + + A A M + + + A + + A + + + A A + +| 31 | Lymphoma Malignant Mixed | X| 1 | __________________________________________________________________________|____________| Intestine Large | + + + A + + + + + + + + + A + + + + + + A + + +| 40 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + A + + + + A + + + + + + A A + +| 35 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + + + + + + + A + + + + + + A A + +| 38 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A M M + + M + + M + + + A + + M + + + A + + +| 34 | __________________________________________________________________________|____________| Intestine Small | + A + A + + + + A + + + + A + + A + + + A A + +| 35 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + A + + + A A + M M + A + + A + + + A A + +| 27 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + A + + + + A + + + A A + + A + + + A A + +| 33 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A M A + + + + A + + + + A + + A + + + A A + +| 33 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Hepatocellular Carcinoma | X X X X | 7 | Hepatocellular Adenoma | X X | 5 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X| 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________|____________| Mesentery | + | 2 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + I + + + + A + +| 42 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | X X X| 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Hemangioma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X| 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 45 | Lymphoma Malignant Lymphocytic | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| | DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| | | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A | CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Spindle Cell, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Adenoma | | 1 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | X X | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + I + + I + + + + + + M| 41 | Pheochromocytoma Malignant | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + M I I I + I + I + + + + I M M M I + + + M M +| 25 | __________________________________________________________________________|____________| Parathyroid Gland | M I + M M M + M + M + + I + + M M + M M M + M +| 23 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + I + + + + + + M + + +| 42 | Adenoma | X X X| 5 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + M + + + + + + + + + + + + + + A + + +| 43 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + + | 4 | Fibrosarcoma | | 1 | Hemangioma | X | 1 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + M + + + + + + + M + + I + + M + + + + + + +| 38 | Adenocarcinoma, Metastatic, Uterus | | 1 | Adenoma | X | 1 | Luteoma | X | 2 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X X| 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + I + + + + + + + + + + M + + +| 44 | Adenocarcinoma | | 1 | Lymphoma Malignant Mixed | X| 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| | DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| | | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A | CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + A + + + + + + + + + + + + + + + + + A + +| 41 | Lymphoma Malignant Mixed | X| 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Axillary, Lymphoma Malignant Mixed | X| 1 | Iliac, Lymphoma Malignant Mixed | X| 1 | Iliac, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Pancreatic, Lymphoma Malignant Mixed | X| 1 | Renal, Lymphoma Malignant Mixed | X| 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + + + M + + + + + + + + + + + M + + +| 38 | Adenocarcinoma, Metastatic, Uterus | | 1 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | X X| 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + M M + + M + + + M + + M + +| 35 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X| 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + M M M + + M M M M M M M M M M M M + M +| 13 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X| 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + I + + + + M M + M +| 35 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | X X| 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 45 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X| 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| | DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| | | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A | CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + + + + + + + M + M + + + + M + + + + + M + I +| 40 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | X X| 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + M + + + A + + +| 41 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + M + + + + + I + + + + + + + + + + + +| 42 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Alveolar/Bronchiolar Adenoma | X | 3 | Alveolar/Bronchiolar Carcinoma | X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 2 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | X X X| 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + M + + + + A A + +| 40 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X| 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | +| 2 | Adenoma | X| 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| | DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| | | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A | CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X| 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + +| 44 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X| 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | X X X| 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| DAY ON TEST | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2| | 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| ANIMAL ID | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0| 6 MG/M3 | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + A + + + + A + + M A A A + + A A A + + + +| __________________________________________________________________________| Intestine Large | A + + + + + + + A + + + A A A + + A + A + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + A + + + + A + + A A A A + + A A A + + + +| __________________________________________________________________________| Intestine Large, Colon | A + + + + + + + A + + A A A A + + A + A + + + +| Leiomyosarcoma | | __________________________________________________________________________| Intestine Large, Rectum | A M + + + + M + A + + + M A A + + A A A M I M +| __________________________________________________________________________| Intestine Small | A + + A + + + + A + + A A A A + + A A A + + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + + A + + + + A + + A A A A + + A A A + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + A + + + + A + + A A A A + + A A A A + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + A + + + + A + + A A A A + + A A A + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + A + + + + + + + + + +| Hemangioma | X | Hepatocellular Carcinoma | | Hepatocellular Adenoma | X | __________________________________________________________________________| Pancreas | + + I + + + + + A + + + I A A + + M + A + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + A + + + + + A + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + A + + + +| __________________________________________________________________________| Stomach, Glandular | + + + A + + + + A + + + + A + + + A + A + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + A + + + + + A + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + M A + + + + + A + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + A + + + + + A + + + +| __________________________________________________________________________| Islets, Pancreatic | + + I I I + M + A + I I M A M + M M I A + + + I| __________________________________________________________________________| Parathyroid Gland | + M M M M I I + M M + + + M M + M M + M M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + I M I + + + M + + + + +| Adenoma | X X X| Carcinoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| DAY ON TEST | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2| | 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| ANIMAL ID | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0| 6 MG/M3 | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + M M + + + + M A + + + + + + + + M +| Adenoma | | Cystadenoma | X| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + A + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + A + A + + + +| __________________________________________________________________________| Lymph Node | A + + + + + + + + + + + + + + + + + + + + + + +| Iliac, Lymphoma Malignant Lymphocytic| X | Iliac, Lymphoma Malignant Mixed | X | Pancreatic, Lymphoma Malignant | | Lymphocytic | X | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Bronchial | M + I M + I + + + + + M + + + + M M + + + + I +| Adenocarcinoma, Metastatic, Kidney | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | M + + + M + + + M + + + + + M + M M + M + + M +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mediastinal | M M M M M + M M M + M M + M M + + + I M + + M M| Adenocarcinoma, Metastatic, Kidney | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Lymph Node, Mesenteric | A + + + + + + + A + I M + A + M + A + A + M + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + A + + + + + A + + + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Thymus | + + + I + + + + + + + M + M I + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7| DAY ON TEST | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2| | 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| ANIMAL ID | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0| 6 MG/M3 | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + M + I + + + + + + I +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Vertebra, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + A + + + + A + + + + + + + + + + A + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma, Metastatic, Kidney | | Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Nose | + + + + + + + + A + + + + + + + + + + A + + + +| __________________________________________________________________________| Trachea | + + + A + + + + A + + + A M + + + A + A + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + A + + + + + + + + + +| Adenocarcinoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + A + A + + + A + A + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X X | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| | DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| | | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A | 6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Gallbladder | + A + + M A + A A + M A + + A + + + + A + A + + +| 29 | __________________________________________________________________________|____________| Intestine Large | + + + + A A + + A + A A + + + + + + + + + A A + +| 35 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A A + + A + A A + + A + + + + A + A A + +| 30 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A A + + A + A A + + + + + + + + + A A + +| 34 | Leiomyosarcoma | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + M + + A A + M A + A A + + M I + + M + + A M + M| 23 | __________________________________________________________________________|____________| Intestine Small | + + + + A A + + A + A A + + A + + + + A + A A + +| 30 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + A A + + A + A A + I A + + + + A + A A M M| 26 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + A A + + A + A A + + A + + + + A + A A + +| 28 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A A + + A + A A + + A + + M + A + A A + +| 29 | __________________________________________________________________________|____________| Liver | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 | Hemangioma | | 1 | Hepatocellular Carcinoma | X X X X X| 5 | Hepatocellular Adenoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + A + + + + + A + + + + + + + + + + + + + +| 40 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + A A + + + + + A + + + + + + + + + A + + +| 40 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| 45 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + I A + + + + + + + + + + + I + + + + + + + +| 44 | __________________________________________________________________________|____________| Islets, Pancreatic | I + I + A M M M + I M I I + I + + + + + + M I + +| 21 | __________________________________________________________________________|____________| Parathyroid Gland | M + M + A I I + + M I + M I M + M M + M I M + M +| 19 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + M + + + + + + + + + + + M + + + + + + +| 43 | Adenoma | X | 4 | Carcinoma | X X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| | DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| | | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A | 6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicular Cell, Adenoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + A + + + + + + + + + + + + + + + + + + + +| 43 | Adenoma | X | 1 | Cystadenoma | | 1 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + A + + + A + + + + + + + + + + + + + + + +| 46 | Lymphoma Malignant Lymphocytic | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + A + + + + + + + + + + + + + + + + A A + +| 44 | __________________________________________________________________________|____________| Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 | Iliac, Lymphoma Malignant Lymphocytic| | 1 | Iliac, Lymphoma Malignant Mixed | | 1 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | | 1 | Renal, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + M + + + + M + + + + I + + + + + + M + +| 37 | Adenocarcinoma, Metastatic, Kidney | X | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X X | 3 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + M M + + + + + + + M + + + + + + + + + + +| 38 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + M + M + M + + M M M M M M + M M M M M M| 17 | Adenocarcinoma, Metastatic, Kidney | X | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X | 1 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + I A M + + + + M + + M + + + + M M + + M + +| 32 | Lymphoma Malignant Lymphocytic | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| | DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| | | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A | 6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Spleen | + + + + A A + + + + + + + + + + + + + + + + + + +| 45 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Thymus | + + + + + M + + + + M + + + I + + + + M + + + + +| 41 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | X X | 2 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Mixed | | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Skin | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Vertebra, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + A + + + + + + + + + I + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenocarcinoma, Metastatic, Kidney | X | 1 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Carcinoma | X X X | 4 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 2 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Trachea | + + + + A + + + + + M + + + + + + + + + + A M M M| 37 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + + | 2 | Adenoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| | DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| | | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A | 6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 | Adenocarcinoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + A A + + A + + + + + + + + + + + + A + + +| 41 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | X | 3 | Lymphoma Malignant Mixed | X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3| | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8| 18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M M M A A A M + A A + A + A + A + M + M + + A + +| __________________________________________________________________________| Intestine Large | A A A + + A A + A A + + + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Large, Cecum | A A A + A A A + A A + + + + + + + + + + + + A + +| Leiomyoma | | __________________________________________________________________________| Intestine Large, Colon | A A A + A A A + A A + A + + + + + + + + + + A + +| __________________________________________________________________________| Intestine Large, Rectum | A A M + + A A + A M + + + + + M M + + + M + A + +| __________________________________________________________________________| Intestine Small | A A A + A A A + A A + + + A + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Duodenum | A A A + A A A M A A + A M A + M + + + + M + A + +| __________________________________________________________________________| Intestine Small, Ileum | A A A A A A A + A A + + + A + + + + + + + + A + +| __________________________________________________________________________| Intestine Small, Jejunum | A A A + A A A + A A + A + A + A + + + + + + A + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X X | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Pancreas | + + A + M A + + + + + + + + + + + + + + + + A + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + A + + + + + A + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Adrenal Gland, Medulla | I I + M + + I + + + + + + + I + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + M I M A M + + M I + M I I M + I + I + I A I I| __________________________________________________________________________| Parathyroid Gland | M M M + + M M M I + I + + M + + + + + I M M + M M| __________________________________________________________________________| Pituitary Gland | + + + + M I + + + + + + + + + + + + + + + + + + +| Adenoma | X X | __________________________________________________________________________| Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3| | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8| 18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | | | __________________________________________________________________________| Tissue NOS | | Hemangioma | | Hemangiosarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Uterus | + M + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma Adenosquamous | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + A + + + + + + + + + + + + A + + + + + + + A +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node | M + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Lymphoma Malignant Mixed | X | Iliac, Lymphoma Malignant Lymphocytic| | Iliac, Lymphoma Malignant | | Undifferentiated Cell Type | | Pancreatic, Lymphoma Malignant | | Lymphocytic | | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | X | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Lymph Node, Bronchial | M M I + M M M + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mandibular | M M + M + + + M + + + + + + M + I + + M + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mediastinal | M M M M M M M M + + M M M M M + M M + M M + + M M| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3| | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8| 18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Cell Type | | __________________________________________________________________________| Lymph Node, Mesenteric | M A A + M M M M + + + + + M + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | M + + M + + M + + + + + + M + + + + I + + + M + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | Thoracic, Ganglioneuroma | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + M + + + + + I + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Hemangiosarcoma, Metastatic, Tissue | | NOS | | Lymphoma Malignant Histiocytic | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3| | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8| 18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | Adenocarcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Urinary Bladder | A + + + + + A + + + + + + A + + + + + + + + A + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| | | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A | 18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 | __________________________________________________________________________|____________| Gallbladder | + + + A + + + + A + + + + + A + + M + A + + + + A| 29 | __________________________________________________________________________|____________| Intestine Large | + + + A + A + + A + + + + + A + + + A + + + + + A| 36 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + A + + A + + + + + A + + + A A + + + + A| 34 | Leiomyoma | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + A + A + + A + + + + + A + + I A A + + + + A| 32 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + M M + A + M + M + A + I M M + I + + + A| 27 | __________________________________________________________________________|____________| Intestine Small | + + + A + A + + A + + + + + A + + + A + + + + + A| 34 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + M A + A + + A + + + + + A + + + A A + + + + A| 27 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + A + + A + + + + + A + A + A A + + + + A| 31 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + A + + A + + + + + A + A + A + + + + + A| 31 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X | 4 | Hepatocellular Adenoma | X X | 4 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________|____________| Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + A| 44 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + I| 46 | Lymphoma Malignant Histiocytic | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + A + + + M + I + M I + M + + + + + I I + I I| 23 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + I + + + M M M + M + M M + + M I M + +| 25 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| | | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A | 18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + | 2 | Hemangioma | X | 1 | Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + I M + + M + + + + + +| 46 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Carcinoma Adenosquamous | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + A| 45 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Axillary, Lymphoma Malignant Mixed | | 1 | Iliac, Lymphoma Malignant Lymphocytic| X | 1 | Iliac, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | X | 1 | Renal, Lymphoma Malignant Lymphocytic| X | 1 | Renal, Lymphoma Malignant Mixed | | 1 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + + + + + + +| 43 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| | | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A | 18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | M M + + + + + + + + + M M M + + + + + M + + + + M| 36 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | X X X | 3 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + M M M + + M M + M M M M M M M + M M M + M M| 14 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + M + M + + A + + + + + M + + + + + + + + M +| 37 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________|____________| Thymus | + + + M + + + + + + + + + + + + + M + + + + + I +| 41 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + I + + + + + + + + + + + + + + + +| 48 | Fibrosarcoma | X | 1 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| | | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A | 18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spinal Cord | | 1 | Thoracic, Ganglioneuroma | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 2 | Alveolar/Bronchiolar Carcinoma | X | 1 | Hemangiosarcoma, Metastatic, Tissue | | | NOS | X | 1 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + M + I + A + + + M + + + + + +| 45 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | Adenocarcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + A + A + + A + + + + + A + + + A + + + + + +| 41 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Histiocytic | X | 1 | Lymphoma Malignant Lymphocytic | X X X | 3 | Lymphoma Malignant Mixed | X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 7| 7| 5| 3| 1| 5| 1| 7| 1| 5| 5| 4| 7| 5| 5| 0| 1| 7| 7| 7| 7| 3| 5| 7| 5| DAY ON TEST | 3| 3| 4| 6| 8| 4| 8| 1| 8| 4| 4| 0| 1| 4| 3| 2| 8| 3| 0| 3| 3| 6| 0| 3| 5| | 2| 2| 9| 9| 5| 9| 5| 1| 6| 9| 9| 4| 5| 9| 2| 8| 6| 2| 1| 2| 2| 8| 4| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7| CONTROL | 8| 9| 0| 3| 5| 7| 8| 6| 7| 8| 0| 2| 3| 4| 9| 6| 7| 8| 9| 7| 8| 9| 6| 8| 2| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + | __________________________________________________________________________| Gallbladder | + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + | __________________________________________________________________________| Intestine Large, Rectum | + I + + + + | __________________________________________________________________________| Intestine Small | + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + | __________________________________________________________________________| Liver | + + + + + + | __________________________________________________________________________| Pancreas | + + + + + + | __________________________________________________________________________| Salivary Glands | + + + + + + | __________________________________________________________________________| Stomach | + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + | __________________________________________________________________________| Stomach, Glandular | + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + | __________________________________________________________________________| Adrenal Gland, Medulla | + M + + + + | __________________________________________________________________________| Islets, Pancreatic | + + + + + + | __________________________________________________________________________| Parathyroid Gland | M + M + M M | __________________________________________________________________________| Pituitary Gland | + + + + + + | __________________________________________________________________________| Thyroid Gland | + + M + + + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + | __________________________________________________________________________| Uterus | + + + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + | __________________________________________________________________________| Lymph Node | + + + + + + | __________________________________________________________________________| Lymph Node, Bronchial | + + + + M + | __________________________________________________________________________| Lymph Node, Mandibular | + M + M + M | __________________________________________________________________________| Lymph Node, Mediastinal | + + M M + + | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + | __________________________________________________________________________| Spleen | + + + + + + | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 7| 7| 5| 3| 1| 5| 1| 7| 1| 5| 5| 4| 7| 5| 5| 0| 1| 7| 7| 7| 7| 3| 5| 7| 5| DAY ON TEST | 3| 3| 4| 6| 8| 4| 8| 1| 8| 4| 4| 0| 1| 4| 3| 2| 8| 3| 0| 3| 3| 6| 0| 3| 5| | 2| 2| 9| 9| 5| 9| 5| 1| 6| 9| 9| 4| 5| 9| 2| 8| 6| 2| 1| 2| 2| 8| 4| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7| CONTROL | 8| 9| 0| 3| 5| 7| 8| 6| 7| 8| 0| 2| 3| 4| 9| 6| 7| 8| 9| 7| 8| 9| 6| 8| 2| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + + + | __________________________________________________________________________| Skin | + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + | __________________________________________________________________________| Lung | + + + + + + | Alveolar/Bronchiolar Adenoma | | __________________________________________________________________________| Nose | + + + + + + | __________________________________________________________________________| Trachea | + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + | __________________________________________________________________________| Urinary Bladder | + + + + + + | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 1| 7| 3| 1| 3| 5| 1| 3| 1| 5| 3| 6| 5| 3| | | DAY ON TEST | 8| 3| 6| 8| 6| 4| 8| 6| 8| 5| 6| 9| 7| 6| | | | 6| 2| 8| 6| 9| 9| 7| 9| 7| 0| 9| 4| 6| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 7| 7| 9| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 4| | A | CONTROL | 6| 7| 8| 9| 3| 6| 8| 0| 6| 2| 5| 6| 7| 0| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 11 | __________________________________________________________________________|____________| Gallbladder | M + + + + | 10 | __________________________________________________________________________|____________| Intestine Large | + + + + + | 11 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 11 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 11 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 10 | __________________________________________________________________________|____________| Intestine Small | + + + + + | 11 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 11 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 11 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 11 | __________________________________________________________________________|____________| Liver | + + + + + | 11 | __________________________________________________________________________|____________| Pancreas | + + + + + | 11 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 11 | __________________________________________________________________________|____________| Stomach | + + + + + | 11 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 11 | __________________________________________________________________________|____________| Stomach, Glandular | + + M + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + | 11 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + | 11 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + | 11 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 11 | __________________________________________________________________________|____________| Parathyroid Gland | + + M M + | 5 | __________________________________________________________________________|____________| Pituitary Gland | + + + M + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + M + + | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + | 3 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + | 11 | __________________________________________________________________________|____________| Uterus | + + + + + | 11 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 11 | __________________________________________________________________________|____________| Lymph Node | + + + + + | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 1| 7| 3| 1| 3| 5| 1| 3| 1| 5| 3| 6| 5| 3| | | DAY ON TEST | 8| 3| 6| 8| 6| 4| 8| 6| 8| 5| 6| 9| 7| 6| | | | 6| 2| 8| 6| 9| 9| 7| 9| 7| 0| 9| 4| 6| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 7| 7| 9| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 4| | A | CONTROL | 6| 7| 8| 9| 3| 6| 8| 0| 6| 2| 5| 6| 7| 0| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + | 9 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + | 7 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M M M | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 11 | __________________________________________________________________________|____________| Spleen | + + + + + | 11 | __________________________________________________________________________|____________| Thymus | + + + + + | 11 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 10 | __________________________________________________________________________|____________| Skin | + + + + + | 11 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 11 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 11 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + | 11 | __________________________________________________________________________|____________| Lung | + + + + + | 11 | Alveolar/Bronchiolar Adenoma | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + | 11 | __________________________________________________________________________|____________| Trachea | + + + + + | 11 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 11 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 11 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 3| 5| 5| 3| 3| 7| 1| 7| 6| 3| 1| 1| 6| 5| 7| 7| 1| 5| 0| 6| 7| 1| 3| 0| 5| DAY ON TEST | 6| 4| 4| 6| 6| 1| 8| 3| 5| 6| 8| 8| 5| 4| 3| 3| 8| 4| 1| 7| 3| 8| 6| 0| 2| | 9| 9| 9| 8| 9| 7| 5| 2| 9| 8| 5| 6| 5| 9| 2| 2| 6| 9| 7| 8| 2| 7| 9| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 4| 4| 4| 5| 5| 5| 7| 7| 8| 8| 8| 8| 8| 1| 1| 1| 1| 6 MG/M3 | 7| 8| 1| 3| 5| 6| 7| 8| 6| 8| 9| 1| 7| 9| 7| 9| 0| 2| 4| 6| 8| 0| 2| 3| 4| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + M + + + + + | __________________________________________________________________________| Gallbladder | + + + M + + + + | __________________________________________________________________________| Intestine Large | + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + M | __________________________________________________________________________| Intestine Small | + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + | __________________________________________________________________________| Pancreas | + + + + + M + + | __________________________________________________________________________| Salivary Glands | + + + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + | __________________________________________________________________________| Islets, Pancreatic | + + + + + M + + | __________________________________________________________________________| Parathyroid Gland | M + + M M M M M | __________________________________________________________________________| Pituitary Gland | + + + M M + + + | __________________________________________________________________________| Thyroid Gland | + + + + + + M + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + M + + + + + | __________________________________________________________________________| Uterus | + + + + + + + + | Endometrium, Polyp | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + | __________________________________________________________________________| Lymph Node | + + + + + + + + | __________________________________________________________________________| Lymph Node, Bronchial | M + + M + + + M | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + | __________________________________________________________________________| Lymph Node, Mediastinal | + + + M + M + M | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 3| 5| 5| 3| 3| 7| 1| 7| 6| 3| 1| 1| 6| 5| 7| 7| 1| 5| 0| 6| 7| 1| 3| 0| 5| DAY ON TEST | 6| 4| 4| 6| 6| 1| 8| 3| 5| 6| 8| 8| 5| 4| 3| 3| 8| 4| 1| 7| 3| 8| 6| 0| 2| | 9| 9| 9| 8| 9| 7| 5| 2| 9| 8| 5| 6| 5| 9| 2| 2| 6| 9| 7| 8| 2| 7| 9| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 4| 4| 4| 5| 5| 5| 7| 7| 8| 8| 8| 8| 8| 1| 1| 1| 1| 6 MG/M3 | 7| 8| 1| 3| 5| 6| 7| 8| 6| 8| 9| 1| 7| 9| 7| 9| 0| 2| 4| 6| 8| 0| 2| 3| 4| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + | __________________________________________________________________________| Thymus | + + + + + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + | __________________________________________________________________________| Skin | + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + | __________________________________________________________________________| Lung | + + + + + + + + | __________________________________________________________________________| Nose | + + + + + + + + | __________________________________________________________________________| Trachea | + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1| | | DAY ON TEST | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8| | | | 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| | A | 6 MG/M3 | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + | 11 | __________________________________________________________________________|____________| Gallbladder | + + + M | 10 | __________________________________________________________________________|____________| Intestine Large | + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + | 11 | __________________________________________________________________________|____________| Intestine Small | + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + | 12 | __________________________________________________________________________|____________| Liver | + + + + | 12 | __________________________________________________________________________|____________| Pancreas | + + + + | 11 | __________________________________________________________________________|____________| Salivary Glands | + + + + | 12 | __________________________________________________________________________|____________| Stomach | + + + + | 12 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + | 12 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + | 12 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | M + + + | 11 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + | 12 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + | 11 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | I + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + | 11 | __________________________________________________________________________|____________| Parathyroid Gland | M M + M | 3 | __________________________________________________________________________|____________| Pituitary Gland | M M + + | 8 | __________________________________________________________________________|____________| Thyroid Gland | M M + + | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 4 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + | 11 | __________________________________________________________________________|____________| Uterus | + + + + | 12 | Endometrium, Polyp | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1| | | DAY ON TEST | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8| | | | 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| | A | 6 MG/M3 | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + | 12 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M M + M | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + | 11 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M M | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + | 11 | __________________________________________________________________________|____________| Spleen | + + + + | 12 | __________________________________________________________________________|____________| Thymus | + + + + | 12 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + | 12 | __________________________________________________________________________|____________| Skin | + + + + | 12 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + | 12 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + | 12 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + | 12 | __________________________________________________________________________|____________| Lung | + + + + | 12 | __________________________________________________________________________|____________| Nose | + + + + | 12 | __________________________________________________________________________|____________| Trachea | M + + + | 11 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 2 | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + | 12 | __________________________________________________________________________|____________| Urinary Bladder | + + + + | 12 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 0| 0| 1| 7| 0| 0| 4| 3| 1| 7| 3| 5| 3| 7| 5| 1| 2| 3| 5| 1| 5| 1| 5| 7| 7| DAY ON TEST | 2| 2| 1| 2| 2| 2| 9| 6| 8| 3| 6| 4| 6| 3| 0| 8| 8| 6| 4| 8| 4| 8| 4| 3| 3| | 8| 8| 4| 2| 8| 8| 5| 9| 6| 2| 8| 6| 9| 2| 8| 5| 6| 8| 9| 7| 9| 5| 9| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 5| 5| 6| 6| 6| 6| 6| 6| 8| 9| 9| 9| 18 MG/M3 | 7| 8| 9| 0| 5| 8| 9| 6| 0| 1| 3| 5| 7| 7| 8| 2| 3| 4| 5| 8| 9| 7| 1| 3| 5| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | M + + + | __________________________________________________________________________| Gallbladder | M M + + | __________________________________________________________________________| Intestine Large | + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + | __________________________________________________________________________| Intestine Large, Rectum | + + + + | __________________________________________________________________________| Intestine Small | + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + | __________________________________________________________________________| Intestine Small, Jejunum | + + + + | __________________________________________________________________________| Liver | + + + + | Hepatocellular Adenoma | | __________________________________________________________________________| Pancreas | + + + + | __________________________________________________________________________| Salivary Glands | + + + + | __________________________________________________________________________| Stomach | + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + | __________________________________________________________________________| Stomach, Glandular | + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + | __________________________________________________________________________| Islets, Pancreatic | + I + + | __________________________________________________________________________| Parathyroid Gland | M + + + | __________________________________________________________________________| Pituitary Gland | + + + + | __________________________________________________________________________| Thyroid Gland | M + + + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + | __________________________________________________________________________| Uterus | + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + | __________________________________________________________________________| Lymph Node | + + + + | __________________________________________________________________________| Lymph Node, Bronchial | + + + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + | __________________________________________________________________________| Lymph Node, Mediastinal | I M M M | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 0| 0| 1| 7| 0| 0| 4| 3| 1| 7| 3| 5| 3| 7| 5| 1| 2| 3| 5| 1| 5| 1| 5| 7| 7| DAY ON TEST | 2| 2| 1| 2| 2| 2| 9| 6| 8| 3| 6| 4| 6| 3| 0| 8| 8| 6| 4| 8| 4| 8| 4| 3| 3| | 8| 8| 4| 2| 8| 8| 5| 9| 6| 2| 8| 6| 9| 2| 8| 5| 6| 8| 9| 7| 9| 5| 9| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 5| 5| 6| 6| 6| 6| 6| 6| 8| 9| 9| 9| 18 MG/M3 | 7| 8| 9| 0| 5| 8| 9| 6| 0| 1| 3| 5| 7| 7| 8| 2| 3| 4| 5| 8| 9| 7| 1| 3| 5| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + | __________________________________________________________________________| Thymus | + + + + | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + | __________________________________________________________________________| Skin | + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + | __________________________________________________________________________| Lung | + + + + | __________________________________________________________________________| Nose | + + + + | __________________________________________________________________________| Trachea | + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + | Transitional Epithelium, Papilloma | | __________________________________________________________________________| Urinary Bladder | + + + + | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3| | | DAY ON TEST | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6| | | | 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5| | A | 18 MG/M3 | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + M | 10 | __________________________________________________________________________|____________| Gallbladder | M + + + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Rectum | + M + + + + + + | 11 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 12 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 12 | Hepatocellular Adenoma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 12 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 12 | __________________________________________________________________________|____________| Stomach | + + + + + + + + | 12 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 12 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 12 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + | 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + | 12 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + | 12 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | M + + + + + + + | 11 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 11 | __________________________________________________________________________|____________| Parathyroid Gland | + M M + M + + + | 8 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + | 12 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 11 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + | 4 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + | 12 | __________________________________________________________________________|____________| Uterus | + + + + + + + + | 12 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + A + | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3| | | DAY ON TEST | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6| | | | 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5| | A | 18 MG/M3 | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 12 | __________________________________________________________________________|____________| Lymph Node, Bronchial | I + + + + + + + | 11 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M + + | 11 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M M M M M M | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 12 | __________________________________________________________________________|____________| Thymus | + + + + + + + + | 12 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 12 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 12 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 12 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 12 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + | 12 | __________________________________________________________________________|____________| Lung | + + + + + + + + | 12 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 12 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 12 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 12 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 12 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0| DAY ON TEST | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0| | 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| CONTROL | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + M + + M + + + + + + + + + + + M| __________________________________________________________________________| Gallbladder | M + M + + A A + M + + + + + M A + + + + + + + M| __________________________________________________________________________| Intestine Large | + + + + + A A + + + + + + + + A + + + + + + + A| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A A + + + + + + + + A + + + + + + + A| __________________________________________________________________________| Intestine Large, Colon | + + + + + A A + + + + + + + + A + + + + + + + A| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + A A + + + + + + + + A + + + + + + + A| __________________________________________________________________________| Intestine Small | + + + + + A A + + + + + + + + A + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A A + A + + + + + + A + + + + + + + A| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + A A + + + + + + + + A + + + + + + + A| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A A + + + + + + + + A + + M + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + A| Hemangiosarcoma | | Hemangiosarcoma, Metastatic, Spleen | X | Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | X | __________________________________________________________________________| Pancreas | + + + + + A + + + + + + + + + A + + + + + + + M| Hepatocellular Carcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + I + + + + + + + + + + + A| __________________________________________________________________________| Stomach, Glandular | + + + + + M A + + + + + + + + A + + + + + + + A| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | I + + + + + M + + + + + + + + + + + + + + + + A| Spindle Cell, Adenoma | | __________________________________________________________________________| Adrenal Gland, Cortex | I + + + + + M + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Adrenal Gland, Medulla | M + + + + M M M + + + + + + + + + + + + + + + A| Pheochromocytoma Malignant | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + M + M + + I M + + + A + M I + + I + M| __________________________________________________________________________| Parathyroid Gland | + M M M + M M M M + M + + M + + + + M M M + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + M| Adenoma | | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0| DAY ON TEST | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0| | 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| CONTROL | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + M + + M + + I + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + | __________________________________________________________________________| Prostate | + + + + + I + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Seminal Vesicle | + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + A + + + + + + + A| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + A + + + + + A + + + A + + + + + + + A| Hemangiosarcoma, Metastatic, Spleen | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + M| Iliac, Lymphoma Malignant | | Undifferentiated Cell Type | | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + M I + + + M + + + + + + M M + M| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mandibular | M + M M + M + + M M M M + M M M + + + + M + + M| __________________________________________________________________________| Lymph Node, Mediastinal | M M M M M M I + M M + + M M M M + M M M M M M M| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + I M + M + + + + + + + M + + + + + + + M| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + A| Hemangiosarcoma | X X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | M + + + + M + + I I + M + + + A + + + + + + + M| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M + + M M M + M M M M + M M M| _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0| DAY ON TEST | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0| | 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| CONTROL | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + I + + + + + I + + + + + A + + + + + + + A| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + A| Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Carcinoma | X X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Hemangiosarcoma, Metastatic, Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + M + + + + + + + + + A| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + A| Carcinoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + A| Sarcoma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | | DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | | | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A | CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + M + + + M + + + | 41 | __________________________________________________________________________|____________| Gallbladder | + + M + + + + + + + + + + A M + M A A + + A | 31 | __________________________________________________________________________|____________| Intestine Large | + + A + + + + + + + + + + A A + A A A + + + | 36 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + A + + A A + A A A + + A | 34 | __________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + + + + + A A + A A A + + + | 36 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | I + A + + + + + + + A + M A A + A A A + + M | 32 | __________________________________________________________________________|____________| Intestine Small | + + A + + + + + + + A + + A A + A A A + + A | 34 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + M + A + + A A + A A A + + A | 32 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + A + A A A + A A A + + A | 33 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + + A + A A A + A A A + + A | 32 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + | 45 | Hemangiosarcoma | X | 1 | Hemangiosarcoma, Metastatic, Spleen | | 1 | Hepatocellular Carcinoma | X X X | 6 | Hepatocellular Adenoma | X | 1 | Hepatocellular Adenoma, Multiple | X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + A + + + + | 42 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + M | 43 | __________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + A + I + | 39 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + | 45 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + | 43 | Spindle Cell, Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + | 43 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + I | 39 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 41 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | | DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | | | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A | CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Malignant | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + I M + M I + I I + M I + + + + I A M + + | 26 | __________________________________________________________________________|____________| Parathyroid Gland | + M M + M + + + + + + M M M + M + + + + M + | 25 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + | 44 | Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + | 45 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + M + + M + + + + M + + M + + + + + + + | 39 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + | 8 | __________________________________________________________________________|____________| Prostate | M + M I + + + + + + + + + + M + + + + + + + | 40 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + A + + A A + + A | 41 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + M + + + + + + + | 43 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + A + + + + + + + + + + + + + + + A + + + | 40 | Hemangiosarcoma, Metastatic, Spleen | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + | 45 | Iliac, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Pancreatic, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + + + M + + + M I M + + I M M I | 32 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M M + + M + + + M + + + M M M M M + + M | 23 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + M M M M M M M + M M M + M M M M M + M M | 9 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + A + + + + + I + M + + + M + + + A + + + | 36 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | | DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | | | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A | CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + M + + + + + + + + + + + + | 44 | Hemangiosarcoma | | 2 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Thymus | I + M + + + + + + + + + I M M + + + + + + + | 34 | Lymphoma Malignant Mixed | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M + M I M M M M M M M M M M I M M M | 5 | __________________________________________________________________________|____________| Skin | + I + + + + + + + + + + M + + + + + + + + + | 44 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + | 46 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + | 46 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + | 42 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + | 45 | Alveolar/Bronchiolar Adenoma | X X | 6 | Alveolar/Bronchiolar Carcinoma | X X | 6 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 1 | Hemangiosarcoma, Metastatic, Liver | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + | 45 | __________________________________________________________________________|____________| Trachea | + + A + + + + + + + + + + + + + + A + + + + | 42 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Harderian Gland | | 1 | Adenoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + | 45 | Carcinoma, Metastatic, Uncertain | | | Primary Site | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + | 43 | Sarcoma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + | 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | | DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | | | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A | CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant Mixed | X X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6| | 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6 MG/M3 | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Gallbladder | + + + M + + + A + + A + A A + I + + + I + + I | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Large | + + + A + + + + + + A + A A + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + A + + A + A A + + + + + + + + A | __________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + A + A A + + + + + + + + + | __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + + + + A I A M + + + + + + M + A | __________________________________________________________________________| Intestine Small | + + + A + + + A + + A + A A + + + + + + + + A | __________________________________________________________________________| Intestine Small, Duodenum | + + + A M + + A + M A + A A + + + + + + + + A | __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + A + + A + A A + A + + + + + + A | Adenocarcinoma | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + A + + A + A A + + + + M + + + A | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + | Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Pancreas | + + + A + + + + + + M + M M + + + + + + + + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + A + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach | + + + A + + + + + + + + A A + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + A + + + + + + + + A A + + + + + + + + I | __________________________________________________________________________| Stomach, Glandular | + + + A + + + + + + + + A A + + + + + + + + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + M + + + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + A + + + + + + + + + + + + | Spindle Cell, Adenoma | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + A + + + + + + + + + + + + | Adenoma | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Adrenal Gland, Medulla | M M + + + + + + + + A + + + + + + + + + + + I | __________________________________________________________________________| Islets, Pancreatic | + M + A M I M + M + M I M M + M M + I + I + + | __________________________________________________________________________| Parathyroid Gland | M + M + M M M + + M M + M M + M + + I M I M + | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6| | 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6 MG/M3 | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | | | __________________________________________________________________________| Tissue NOS | + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + M + + I + A + + + + + + + + + M + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Preputial Gland | + + | __________________________________________________________________________| Prostate | + + + A + + + + + + + + + + + M + + + + + + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Seminal Vesicle | + + + A + + + + + + A + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Testes | + + + + + + + + + + A + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + + + + + + + + + I + + M M + + + + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mandibular | + M M M M + M + + + M + M + + + M M + M M M M | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mediastinal | + M M M M M M M + M M + M M M M M M M + M M M | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + M M + + + M + + M + M + + M + + + + + + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Spleen | + + + + + + + + + + A + + A + + + + + + + + + | __________________________________________________________________________| Thymus | + + + M + + + + + + A + M + M M M I + + + M + | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + M M M M M M + M M M M M M M + M M M M M M | __________________________________________________________________________| Skin | + + + + + + I + M + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + I + A + + + + + + A + A A + + + + + + + + + | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + | Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6| | 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6 MG/M3 | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Liver | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + A I + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Urinary Bladder | + + + A + + + A + + A + A A + + + + + + + + + | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5| | | DAY ON TEST | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5| | | | 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| | A | 6 MG/M3 | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 46 | __________________________________________________________________________|____________| Gallbladder | + + + + + A + M A + + + A M M + A A + + A + + A | 29 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Large | + + + + + A + + A + + + A + + + A + + + + + + A | 38 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A + + A + + + A + A + A + + + + + + A | 35 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + A + + A + + + A + + + A + + + + + + A | 38 | __________________________________________________________________________|____________| Intestine Large, Rectum | M + + + + A + + A + + + A + + + A M + + + + M A | 32 | __________________________________________________________________________|____________| Intestine Small | + + + + + A + + A + + + A A A + A + + + + + + A | 34 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + A + + A + + + A A A + A + + A A + + A | 30 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + A + + A + + + A A A + A + + + A + + A | 32 | Adenocarcinoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + A + + A + + + A A A + A A + + + M + A | 31 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 47 | Hepatocellular Carcinoma | X X | 5 | Hepatocellular Adenoma | X X X | 8 | Hepatocellular Adenoma, Multiple | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Pancreas | I + + + + + + + M + + + + + A + + + + + + + + A | 39 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 46 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + A | 43 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + I + + + + + + + + + A | 41 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A | 43 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Tooth | + + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 46 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 46 | Spindle Cell, Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 46 | Adenoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + I + + M M + + + + + + + + + + + + + + M + + | 39 | __________________________________________________________________________|____________| Islets, Pancreatic | I I I M I I I I M + I + + + A + M + + + + + + A | 20 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5| | | DAY ON TEST | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5| | | | 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| | A | 6 MG/M3 | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | M + M + + + M M + + + + M M M + M + M M M + + I | 21 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + M + + + + + + M + + + + + + + + | 44 | Pars Intermedia, Adenoma | X X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + I + + + + + + + | 46 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 3 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + I A + + + + + + + + + + + + I + + I + + | 39 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + | 6 | __________________________________________________________________________|____________| Prostate | + + + + + + + + I + + + + + + + + + + + + + + A | 43 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + A + + + + + + + + + + + + + + + + + A | 43 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Testes | + + + + + A + + + + + + + + + + + + + + + + + A | 44 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + A + + + A + + + A + + A + + + A | 42 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + | 46 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M + + + M + + + + + + M + + + + + + M + | 39 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + M + M + + + M + + + M + M M + + M + M M M + | 23 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M M + M M M + M M M M + + M M M M M M M M + + | 10 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + M | 39 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + A | 44 | __________________________________________________________________________|____________| Thymus | + + I + + I + + + + + M + + M + I + + + + + I + | 33 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M + M M M + M M M M M A | 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 45 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5| | | DAY ON TEST | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5| | | | 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| | A | 6 MG/M3 | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4| | L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 47 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + A | 41 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 47 | Alveolar/Bronchiolar Adenoma | X | 4 | Alveolar/Bronchiolar Carcinoma | X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + A | 46 | __________________________________________________________________________|____________| Trachea | + + + + M + + + + + + + + + + + + + + + + + + A | 43 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + A | 46 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Urinary Bladder | M + + + + A + + + + + + + + + + A + + + + + + A | 38 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + | 47 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| DAY ON TEST | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3| | 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| 18 MG/M3 | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + M M + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | A + + A M + + + A + + + A + A + + + A + + A + + +| __________________________________________________________________________| Intestine Large | + + + + A + + + + + + + A + A + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + A A + + + + + + + A + A + + + A + + A + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + A + + + + + + + A + A + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Rectum | + + I M A M + + M + + + A + M + M I + + + A + + M| __________________________________________________________________________| Intestine Small | A + + A A + + + + + + + A + A + + + A + + A + + +| __________________________________________________________________________| Intestine Small, Duodenum | A + M M A + + + + + + + A + A + + + A + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + A A + + + A + + + A + A + + + A + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + A A + + + + + + + A + A + + + A + + A + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Adenoma | X X X | __________________________________________________________________________| Pancreas | + + M + + + + + + + I + + + + + + + + + + A + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + A + + +| Spindle Cell, Adenoma | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +| Adenoma | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + M + + + + + I + + + + + + + + + + + + A + + +| __________________________________________________________________________| Islets, Pancreatic | I I M + I I I M + + I I + I + + + I + + + A + + M| __________________________________________________________________________| Parathyroid Gland | + + I M + + I M + M + M + + + M + + + + + A M + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Thyroid Gland | + + + I + + + + + + + + + + + + + + + + + A + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Hemangioma | | Hemangiosarcoma, Metastatic, Spleen | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + M + + + + + + + + + + + + + M + + +| _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| DAY ON TEST | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3| | 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| 18 MG/M3 | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Preputial Gland | + + + + | __________________________________________________________________________| Prostate | M + + + + + + + M + + + + + + + + + + + + A + + +| __________________________________________________________________________| Seminal Vesicle | M + + + + + + + M + + + + + + + + + M + + A + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + A + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + A A + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + M + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Lymph Node, Mandibular | I + + M M + + M I M M M + M M + + M M I M M + M +| Hemangiosarcoma, Metastatic, Spleen | X | __________________________________________________________________________| Lymph Node, Mediastinal | M + M M M M M M M M M M + M M M + M + M M M M M M| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + M + + + + + + A + + +| Hemangiosarcoma, Metastatic, Spleen | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +| Hemangiosarcoma | X X | __________________________________________________________________________| Thymus | M + + + + + + M + + + + + + + + + + M + + A + + M| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | I M + M I M M M M M M M M M + M + M M I M M + + I| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | X | __________________________________________________________________________| Skeletal Muscle | + | Thoracic, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X | Alveolar/Bronchiolar Carcinoma | X | Hemangiosarcoma, Metastatic, Spleen | X | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7| DAY ON TEST | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3| | 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5| 18 MG/M3 | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Hepatocellular Carcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + A + + + + + + A + I +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + + | Adenoma | X X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + A + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3| | | 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| A | 18 MG/M3 | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Gallbladder | + I A + + M + M + + + + + A + + + + + + + + A +| 35 | __________________________________________________________________________|____________| Intestine Large | + + A + A A + A + + + + + + + + + + + + + + A +| 40 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + A A + A + + + + + A + + + + + + + + A +| 37 | __________________________________________________________________________|____________| Intestine Large, Colon | + + A + A A + A + + + + + A + + + + + + + + A +| 39 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + A M A A + A + + + + M + + + + + + + + + A +| 31 | __________________________________________________________________________|____________| Intestine Small | + + A + A A + A + + + + + A + + + + + + + + A +| 36 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + A A + A + + + + + A + + + + + + M + A +| 34 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + A A + A + + + + + A + + + + + + + + A +| 35 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + A A + A + + + + + A + + + + + + + + A +| 36 | __________________________________________________________________________|____________| Liver | + + + + + + + A + + + + + + + + + + + + + + + +| 48 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X X X | 11 | Hepatocellular Adenoma | X | 4 | __________________________________________________________________________|____________| Pancreas | + + A + A A + A + + + + + + + + + + + + + + + +| 42 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + A + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Stomach | + + + + + A + A + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + A + A + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Stomach, Glandular | + + A + A A + A + + + + + + + + + + + + + + A +| 43 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + A + + + + + + + + + + + + + + + +| 47 | Spindle Cell, Adenoma | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + A + + + + + + + + + + + + + + + +| 47 | Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + M + + + M A + + + + + + + I + + + + + + + +| 42 | __________________________________________________________________________|____________| Islets, Pancreatic | + + A M A A M A M + + I I + I + + + + + I M + +| 24 | __________________________________________________________________________|____________| Parathyroid Gland | + M M M M + + A M M M M M + M + + M + + + M + +| 26 | __________________________________________________________________________|____________| Pituitary Gland | + + + + M + + A + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + A + + + I + + + + + + + + + + + +| 45 | Follicular Cell, Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3| | | 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| A | 18 MG/M3 | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | Hemangioma | X | 1 | Hemangiosarcoma, Metastatic, Spleen | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + A + + A + + + + + + M + M + + + + + + M| 42 | __________________________________________________________________________|____________| Preputial Gland | + + + + | 8 | __________________________________________________________________________|____________| Prostate | + + + + + + + A + + + + + M + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Seminal Vesicle | + I A + A A + A + + + + + M + + + + + + + + + +| 39 | __________________________________________________________________________|____________| Testes | + + + + A M + A + + + + + + + + + + + + + + + +| 45 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + A + + A + A + + + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + + + + A + + + + + M + + + + M + + + + +| 44 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M M + M M M A M M + M + + M + + M + M M + + M| 19 | Hemangiosarcoma, Metastatic, Spleen | | 1 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M + M M M M M M M M M M M M M M M + M M M M| 7 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | I + + + A + + A + + + + + M + + + + + + + + M M| 40 | Hemangiosarcoma, Metastatic, Spleen | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + A + + + + + + + + + + + + + + + +| 47 | Hemangiosarcoma | | 2 | __________________________________________________________________________|____________| Thymus | + + + + + + + M + + + + + M + + + + M + + I + +| 40 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + M + M M M M M M M M M M M M + M M M M M M M| 8 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + I + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma, Metastatic, Spleen | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Thoracic, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3| | | 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| A | 18 MG/M3 | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + A + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + A + + A + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Lung | + + + + + + + A + + + + + + + + + + + + + + + +| 48 | Alveolar/Bronchiolar Adenoma | X X X X X| 7 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 2 | Alveolar/Bronchiolar Carcinoma | X | 2 | Hemangiosarcoma, Metastatic, Spleen | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + A + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Trachea | + + + + A M M A + + + + + + + + + + + + + + + +| 42 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 4 | Adenoma | X | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Urinary Bladder | + + + + A A + A + + + + + + + + + + + + + + A +| 43 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 5| 1| 1| 1| 7| 7| 5| 3| 3| 3| 7| 3| 7| 2| 1| 7| 7| 3| 6| 1| 5| DAY ON TEST | 3| 4| 1| 3| 4| 8| 8| 8| 3| 3| 4| 6| 6| 6| 3| 6| 3| 9| 8| 3| 3| 6| 1| 8| 4| | 9| 9| 5| 9| 9| 5| 5| 5| 9| 9| 9| 9| 8| 9| 9| 8| 9| 5| 5| 9| 9| 9| 9| 6| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 6| 6| 6| 6| 6| 6| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 6| 6| CONTROL | 2| 3| 5| 6| 8| 9| 3| 4| 7| 9| 0| 1| 4| 2| 8| 9| 0| 2| 3| 3| 6| 7| 9| 0| 1| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + M + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + I + + +| __________________________________________________________________________| Intestine Small | + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + +| Hepatocellular Carcinoma | X X| Hepatocellular Adenoma | | __________________________________________________________________________| Pancreas | + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + +| Rhabdomyosarcoma, Metastatic, | | Skeletal Muscle | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M M M + + + +| __________________________________________________________________________| Pituitary Gland | + + M + + + + +| __________________________________________________________________________| Thyroid Gland | + + M + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + M M + + + M +| __________________________________________________________________________| Testes | + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + +| _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 7| 5| 7| 7| 5| 1| 1| 1| 7| 7| 5| 3| 3| 3| 7| 3| 7| 2| 1| 7| 7| 3| 6| 1| 5| DAY ON TEST | 3| 4| 1| 3| 4| 8| 8| 8| 3| 3| 4| 6| 6| 6| 3| 6| 3| 9| 8| 3| 3| 6| 1| 8| 4| | 9| 9| 5| 9| 9| 5| 5| 5| 9| 9| 9| 9| 8| 9| 9| 8| 9| 5| 5| 9| 9| 9| 9| 6| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 6| 6| 6| 6| 6| 6| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 6| 6| CONTROL | 2| 3| 5| 6| 8| 9| 3| 4| 7| 9| 0| 1| 4| 2| 8| 9| 0| 2| 3| 3| 6| 7| 9| 0| 1| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + + + +| Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | __________________________________________________________________________| Lymph Node, Bronchial | + + M + + M + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + M M + M +| __________________________________________________________________________| Lymph Node, Mediastinal | + M M + M M + +| Adenocarcinoma, Metastatic, Lung | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + M +| __________________________________________________________________________| Spleen | + + + + + + + +| __________________________________________________________________________| Thymus | + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M M M M M M| __________________________________________________________________________| Skin | + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Rhabdomyosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Metastatic | X | Hepatocellular Carcinoma, Metastatic | X | __________________________________________________________________________| Nose | + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + +| _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7| | | DAY ON TEST | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3| | | | 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2| | A | CONTROL | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + | 11 | __________________________________________________________________________|____________| Gallbladder | + + + + | 12 | __________________________________________________________________________|____________| Intestine Large | + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + M | 10 | __________________________________________________________________________|____________| Intestine Small | + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + | 12 | __________________________________________________________________________|____________| Liver | + + + + | 12 | Hepatocellular Carcinoma | | 2 | Hepatocellular Adenoma | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + | 12 | __________________________________________________________________________|____________| Salivary Glands | + + + + | 12 | __________________________________________________________________________|____________| Stomach | + + + + | 12 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + | 12 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + | 12 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + | 12 | Rhabdomyosarcoma, Metastatic, | | | Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + | 12 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + I + | 11 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + I + | 11 | __________________________________________________________________________|____________| Islets, Pancreatic | + M + + | 11 | __________________________________________________________________________|____________| Parathyroid Gland | M M + M | 6 | __________________________________________________________________________|____________| Pituitary Gland | + + + + | 11 | __________________________________________________________________________|____________| Thyroid Gland | + + + + | 11 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 4 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + | 12 | __________________________________________________________________________|____________| Prostate | + + + + | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7| | | DAY ON TEST | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3| | | | 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2| | A | CONTROL | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Seminal Vesicle | + M + + | 8 | __________________________________________________________________________|____________| Testes | + + + + | 12 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + | 12 | __________________________________________________________________________|____________| Lymph Node | + + + + | 12 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M | 9 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M M | 6 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M M M | 5 | Adenocarcinoma, Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + | 12 | __________________________________________________________________________|____________| Thymus | + + + + | 11 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M + | 3 | __________________________________________________________________________|____________| Skin | + + + + | 12 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + | 12 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Rhabdomyosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + | 12 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + | 12 | __________________________________________________________________________|____________| Lung | + + + + | 12 | Alveolar/Bronchiolar Carcinoma | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic | | 1 | Hepatocellular Carcinoma, Metastatic | | 1 | __________________________________________________________________________|____________| Nose | + + + + | 12 | __________________________________________________________________________|____________| Trachea | + + + + | 12 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7| | | DAY ON TEST | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3| | | | 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | T | ANIMAL ID | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2| | A | CONTROL | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + | 12 | __________________________________________________________________________|____________| Urinary Bladder | + + + + | 12 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 1| 3| 1| 7| 7| 1| 5| 3| 7| 3| 5| 1| 7| 5| 3| 1| 5| 3| 7| 5| 5| 3| 5| 7| 1| DAY ON TEST | 7| 6| 8| 3| 3| 8| 4| 6| 3| 6| 4| 8| 3| 4| 6| 8| 4| 6| 3| 4| 5| 6| 4| 3| 8| | 6| 9| 5| 9| 9| 5| 9| 8| 9| 9| 9| 5| 9| 9| 8| 5| 9| 9| 9| 9| 0| 9| 9| 9| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| 9| 0| 6 MG/M3 | 2| 3| 6| 9| 1| 2| 3| 1| 4| 7| 9| 3| 4| 5| 2| 3| 7| 9| 0| 3| 1| 4| 7| 8| 2| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + M M + + +| __________________________________________________________________________| Gallbladder | + + + + + + + M + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + M + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + +| Hepatocellular Adenoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + M M + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + M M + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + M M + + M + + + +| __________________________________________________________________________| Islets, Pancreatic | M + + + + M M + + +| __________________________________________________________________________| Parathyroid Gland | + M + M M M M M + +| __________________________________________________________________________| Pituitary Gland | + + + M + + I + M +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + M + + M + + + + M| __________________________________________________________________________| Testes | + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Bronchial | M + + I I + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | M + + + + M + + + +| _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 1| 3| 1| 7| 7| 1| 5| 3| 7| 3| 5| 1| 7| 5| 3| 1| 5| 3| 7| 5| 5| 3| 5| 7| 1| DAY ON TEST | 7| 6| 8| 3| 3| 8| 4| 6| 3| 6| 4| 8| 3| 4| 6| 8| 4| 6| 3| 4| 5| 6| 4| 3| 8| | 6| 9| 5| 9| 9| 5| 9| 8| 9| 9| 9| 5| 9| 9| 8| 5| 9| 9| 9| 9| 0| 9| 9| 9| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| 9| 0| 6 MG/M3 | 2| 3| 6| 9| 1| 2| 3| 1| 4| 7| 9| 3| 4| 5| 2| 3| 7| 9| 0| 3| 1| 4| 7| 8| 2| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mediastinal | M M + M M + M M + M| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M M + + + M| __________________________________________________________________________| Spleen | + + + + + + + + + +| __________________________________________________________________________| Thymus | + + + + + + M + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M + M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | __________________________________________________________________________| Nose | + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | A | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1| | | DAY ON TEST | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8| | | | 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6| | A | 6 MG/M3 | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + | 10 | __________________________________________________________________________|____________| Gallbladder | + + | 11 | __________________________________________________________________________|____________| Intestine Large | + + | 12 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + | 12 | __________________________________________________________________________|____________| Intestine Large, Colon | + + | 12 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + | 12 | __________________________________________________________________________|____________| Intestine Small | + + | 12 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + | 12 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + | 11 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + | 12 | __________________________________________________________________________|____________| Liver | + + | 12 | Hepatocellular Adenoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + | 12 | __________________________________________________________________________|____________| Salivary Glands | + + | 12 | __________________________________________________________________________|____________| Stomach | + + | 12 | __________________________________________________________________________|____________| Stomach, Forestomach | + + | 12 | __________________________________________________________________________|____________| Stomach, Glandular | + + | 12 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + | 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + | 10 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + | 10 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + | 9 | __________________________________________________________________________|____________| Islets, Pancreatic | + + | 9 | __________________________________________________________________________|____________| Parathyroid Gland | + + | 6 | __________________________________________________________________________|____________| Pituitary Gland | + + | 9 | __________________________________________________________________________|____________| Thyroid Gland | + + | 12 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 4 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + | 12 | __________________________________________________________________________|____________| Prostate | + + | 12 | __________________________________________________________________________|____________| Seminal Vesicle | + M | 8 | __________________________________________________________________________|____________| Testes | + + | 12 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1| | | DAY ON TEST | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8| | | | 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6| | A | 6 MG/M3 | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + | 12 | __________________________________________________________________________|____________| Lymph Node | + + | 12 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + | 9 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M | 9 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M | 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + | 9 | __________________________________________________________________________|____________| Spleen | + + | 12 | __________________________________________________________________________|____________| Thymus | + + | 11 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M | 3 | __________________________________________________________________________|____________| Skin | + + | 12 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + | 12 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + | 12 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + | 12 | __________________________________________________________________________|____________| Lung | + + | 12 | Alveolar/Bronchiolar Adenoma | | 1 | __________________________________________________________________________|____________| Nose | + + | 12 | __________________________________________________________________________|____________| Trachea | + + | 12 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + | 12 | __________________________________________________________________________|____________| Urinary Bladder | + + | 12 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 65 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 1| 5| 5| 1| 1| 1| 7| 3| 5| 1| 3| 5| 1| 5| 5| 1| 7| 5| 7| 3| 1| 1| 1| 7| 5| DAY ON TEST | 1| 4| 4| 1| 1| 8| 3| 6| 4| 8| 6| 4| 8| 6| 4| 8| 3| 5| 3| 6| 8| 4| 8| 3| 4| | 3| 9| 9| 4| 4| 7| 9| 8| 9| 5| 8| 9| 5| 9| 9| 6| 9| 0| 9| 9| 6| 8| 6| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 9| 9| 9| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 7| 7| 7| 18 MG/M3 | 1| 2| 8| 0| 1| 4| 2| 6| 8| 0| 2| 5| 3| 4| 5| 6| 7| 4| 1| 2| 3| 4| 5| 6| 8| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + M + +| __________________________________________________________________________| Gallbladder | + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + M| __________________________________________________________________________| Intestine Small | + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + +| Hepatocellular Adenoma | X | __________________________________________________________________________| Pancreas | + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + M + +| __________________________________________________________________________| Islets, Pancreatic | + M + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M M M M M| __________________________________________________________________________| Pituitary Gland | + + M + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + M + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + +| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + M + M + M +| __________________________________________________________________________| Testes | + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + +| __________________________________________________________________________| Lymph Node, Bronchial | + + + + + M + +| __________________________________________________________________________| Lymph Node, Mandibular | + M + M M M M | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 _____________________________________________________________________________________________________________________ | 1| 5| 5| 1| 1| 1| 7| 3| 5| 1| 3| 5| 1| 5| 5| 1| 7| 5| 7| 3| 1| 1| 1| 7| 5| DAY ON TEST | 1| 4| 4| 1| 1| 8| 3| 6| 4| 8| 6| 4| 8| 6| 4| 8| 3| 5| 3| 6| 8| 4| 8| 3| 4| | 3| 9| 9| 4| 4| 7| 9| 8| 9| 5| 8| 9| 5| 9| 9| 6| 9| 0| 9| 9| 6| 8| 6| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 9| 9| 9| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 7| 7| 7| 18 MG/M3 | 1| 2| 8| 0| 1| 4| 2| 6| 8| 0| 2| 5| 3| 4| 5| 6| 7| 4| 1| 2| 3| 4| 5| 6| 8| LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mediastinal | M M M + M + M M| __________________________________________________________________________| Lymph Node, Mesenteric | + M + + + + + M| __________________________________________________________________________| Spleen | M + + + + + + +| __________________________________________________________________________| Thymus | + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + + + + + + + +| __________________________________________________________________________| Lung | + + + + + + + +| __________________________________________________________________________| Nose | + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + M + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + +| _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3| | | DAY ON TEST | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6| | | | 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4| | A | 18 MG/M3 | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M + + M | 9 | __________________________________________________________________________|____________| Gallbladder | M + + + | 11 | __________________________________________________________________________|____________| Intestine Large | + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + | 12 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + I | 10 | __________________________________________________________________________|____________| Intestine Small | + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + | 12 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + | 12 | __________________________________________________________________________|____________| Liver | + + + + | 12 | Hepatocellular Adenoma | X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + | 12 | __________________________________________________________________________|____________| Salivary Glands | + + + + | 12 | __________________________________________________________________________|____________| Stomach | + + + + | 12 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + | 12 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + | 12 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + | 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + | 12 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + | 11 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + M + + | 9 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + | 11 | __________________________________________________________________________|____________| Parathyroid Gland | + M M M | 4 | __________________________________________________________________________|____________| Pituitary Gland | + + + + | 11 | __________________________________________________________________________|____________| Thyroid Gland | + + + + | 11 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + + | 5 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + | 12 | __________________________________________________________________________|____________| Prostate | + + + + | 12 | __________________________________________________________________________|____________| Seminal Vesicle | + + + | 8 | __________________________________________________________________________|____________| Testes | + + + + | 12 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 68 NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TALC Date: 04/07/97 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04 __________________________________________________________________________________________________________________________________ | 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3| | | DAY ON TEST | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6| | | | 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4| | A | 18 MG/M3 | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4| | L | LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + | 12 | __________________________________________________________________________|____________| Lymph Node | + + + + | 12 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M M + | 4 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M M + M | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 10 | __________________________________________________________________________|____________| Spleen | + + + + | 11 | __________________________________________________________________________|____________| Thymus | + + + + | 12 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M | | __________________________________________________________________________|____________| Skin | + + + + | 12 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + | 12 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + | 12 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + + + + | 12 | __________________________________________________________________________|____________| Lung | + + + + | 12 | __________________________________________________________________________|____________| Nose | + + + + | 12 | __________________________________________________________________________|____________| Trachea | + + M + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + | 12 | __________________________________________________________________________|____________| Urinary Bladder | + + + + | 12 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + | 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------