TDMS Study 05079-02 Pathology Tables
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 14807966
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|
| 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|
CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Gallbladder | M + + A + + + + + + + A + M + + + I + A + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + + + A A + A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | A + M + + + + + + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + M + + + + M + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + A + + + + + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + + M + M M A A M A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + + + A A + A + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + + + + + + A + A + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + A + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|
| 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|
CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Spindle Cell, Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + M + + + + + + + + + +|
Pheochromocytoma Malignant | |
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + A M A + I + I + + I I|
__________________________________________________________________________|
Parathyroid Gland | M M M M I M + + + + + + + + M + + M + + I +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + M + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Fibrosarcoma | X |
Hemangioma | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + I + I + + + M + + + M + + +|
Adenocarcinoma, Metastatic, Uterus | X |
Adenoma | |
Luteoma | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + A A + A + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant Mixed | |
Iliac, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|
| 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|
CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Undifferentiated Cell Type | X |
Pancreatic, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M I + M + + M + + + + + + + I|
Adenocarcinoma, Metastatic, Uterus | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M + + M + + + + + + M M + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + + M + M + M M M M M M M + M M + M M|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + M + + + + M + + M M + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + I + + A + + I + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|
| 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|
CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + I + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + A + + + + + + + M + A + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| |
DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| |
| 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A |
CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + +| 43 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Gallbladder | + A + A + + + A A M + + + A + + A + + + A A + +| 31 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + + + + A + + + + + + A + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + A + + + + A + + + + + + A A + +| 35 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + A + + + + + + A A + +| 38 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A M M + + M + + M + + + A + + M + + + A + + +| 34 |
__________________________________________________________________________|____________|
Intestine Small | + A + A + + + + A + + + + A + + A + + + A A + +| 35 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A + + + A A + M M + A + + A + + + A A + +| 27 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + + A + + + A A + + A + + + A A + +| 33 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A M A + + + + A + + + + A + + A + + + A A + +| 33 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hepatocellular Carcinoma | X X X X | 7 |
Hepatocellular Adenoma | X X | 5 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X| 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + I + + + + A + +| 42 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X| 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hemangioma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Lymphoma Malignant Lymphocytic | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| |
DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| |
| 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A |
CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Spindle Cell, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Adenoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + I + + I + + + + + + M| 41 |
Pheochromocytoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M I I I + I + I + + + + I M M M I + + + M M +| 25 |
__________________________________________________________________________|____________|
Parathyroid Gland | M I + M M M + M + M + + I + + M M + M M M + M +| 23 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + M + + +| 42 |
Adenoma | X X X| 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + A + + +| 43 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + | 4 |
Fibrosarcoma | | 1 |
Hemangioma | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + M + + + + + + + M + + I + + M + + + + + + +| 38 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Adenoma | X | 1 |
Luteoma | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X X| 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + I + + + + + + + + + + M + + +| 44 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| |
DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| |
| 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A |
CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + A + +| 41 |
Lymphoma Malignant Mixed | X| 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Axillary, Lymphoma Malignant Mixed | X| 1 |
Iliac, Lymphoma Malignant Mixed | X| 1 |
Iliac, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Pancreatic, Lymphoma Malignant Mixed | X| 1 |
Renal, Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + M + + + + + + + + + + + M + + +| 38 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X| 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + M M + + M + + + M + + M + +| 35 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X X| 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + M M M + + M M M M M M M M M M M M + M +| 13 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + I + + + + M M + M +| 35 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X| 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| |
DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| |
| 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A |
CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + M + + + + M + + + + + M + I +| 40 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X| 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + A + + +| 41 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + M + + + + + I + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X| 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + M + + + + A A + +| 40 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X| 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | +| 2 |
Adenoma | X| 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| |
DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| |
| 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A |
CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + +| 44 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | X| 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | X X X| 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|
DAY ON TEST | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|
| 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|
6 MG/M3 | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + A + + + + A + + M A A A + + A A A + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + A + + + A A A + + A + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + A + + A A A A + + A A A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + A + + A A A A + + A + A + + + +|
Leiomyosarcoma | |
__________________________________________________________________________|
Intestine Large, Rectum | A M + + + + M + A + + + M A A + + A A A M I M +|
__________________________________________________________________________|
Intestine Small | A + + A + + + + A + + A A A A + + A A A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + + + + A + + A A A A + + A A A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + A + + A A A A + + A A A A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + + + A + + A A A A + + A A A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + A + + + + + + + + + +|
Hemangioma | X |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
__________________________________________________________________________|
Pancreas | + + I + + + + + A + + + I A A + + M + A + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + A + + + + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + A + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + A + + + + A + + + A + A + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + A + + + + + A + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + M A + + + + + A + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + A + + + + + A + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + I I I + M + A + I I M A M + M M I A + + + I|
__________________________________________________________________________|
Parathyroid Gland | + M M M M I I + M M + + + M M + M M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + I M I + + + M + + + + +|
Adenoma | X X X|
Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|
DAY ON TEST | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|
| 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|
6 MG/M3 | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + M M + + + + M A + + + + + + + + M +|
Adenoma | |
Cystadenoma | X|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + A + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + A + + + +|
__________________________________________________________________________|
Lymph Node | A + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Lymphoma Malignant Lymphocytic| X |
Iliac, Lymphoma Malignant Mixed | X |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + I M + I + + + + + M + + + + M M + + + + I +|
Adenocarcinoma, Metastatic, Kidney | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + + + M + + + + + M + M M + M + + M +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + M M M + M M + M M + + + I M + + M M|
Adenocarcinoma, Metastatic, Kidney | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + A + I M + A + M + A + A + M + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + A + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Thymus | + + + I + + + + + + + M + M I + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|
DAY ON TEST | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|
| 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|
6 MG/M3 | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + I + + + + + + I +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + A + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Kidney | |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Nose | + + + + + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Trachea | + + + A + + + + A + + + A M + + + A + A + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + +|
Adenocarcinoma | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + A + + + A + A + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| |
| 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A |
6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + A + + M A + A A + M A + + A + + + + A + A + + +| 29 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A A + + A + A A + + + + + + + + + A A + +| 35 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A A + + A + A A + + A + + + + A + A A + +| 30 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A A + + A + A A + + + + + + + + + A A + +| 34 |
Leiomyosarcoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + A A + M A + A A + + M I + + M + + A M + M| 23 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A A + + A + A A + + A + + + + A + A A + +| 30 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + A A + + A + A A + I A + + + + A + A A M M| 26 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + A A + + A + A A + + A + + + + A + A A + +| 28 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A A + + A + A A + + A + + M + A + A A + +| 29 |
__________________________________________________________________________|____________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Hemangioma | | 1 |
Hepatocellular Carcinoma | X X X X X| 5 |
Hepatocellular Adenoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + A + + + + + + + + + + + + + +| 40 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A A + + + + + A + + + + + + + + + A + + +| 40 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| 45 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + I A + + + + + + + + + + + I + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Islets, Pancreatic | I + I + A M M M + I M I I + I + + + + + + M I + +| 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + A I I + + M I + M I M + M M + M I M + M +| 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + M + + + + + + +| 43 |
Adenoma | X | 4 |
Carcinoma | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| |
| 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A |
6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + A + + + + + + + + + + + + + + + + + + + +| 43 |
Adenoma | X | 1 |
Cystadenoma | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + A + + + A + + + + + + + + + + + + + + + +| 46 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + A A + +| 44 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Iliac, Lymphoma Malignant Mixed | | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + M + + + + I + + + + + + M + +| 37 |
Adenocarcinoma, Metastatic, Kidney | X | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X | 3 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + + + + + + + M + + + + + + + + + + +| 38 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + M + M + M + + M M M M M M + M M M M M M| 17 |
Adenocarcinoma, Metastatic, Kidney | X | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + I A M + + + + M + + M + + + + M M + + M + +| 32 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| |
| 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A |
6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + A A + + + + + + + + + + + + + + + + + + +| 45 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + M + + + I + + + + M + + + + +| 41 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Skin | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Vertebra, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + A + + + + + + + + + I + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenocarcinoma, Metastatic, Kidney | X | 1 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | X X X | 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 2 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Trachea | + + + + A + + + + + M + + + + + + + + + + A M M M| 37 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Adenoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| |
| 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A |
6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Adenocarcinoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A A + + A + + + + + + + + + + + + A + + +| 41 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Lymphocytic | X | 3 |
Lymphoma Malignant Mixed | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|
| 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|
18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M M A A A M + A A + A + A + A + M + M + + A + +|
__________________________________________________________________________|
Intestine Large | A A A + + A A + A A + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A A + A A A + A A + + + + + + + + + + + + A + +|
Leiomyoma | |
__________________________________________________________________________|
Intestine Large, Colon | A A A + A A A + A A + A + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | A A M + + A A + A M + + + + + M M + + + M + A + +|
__________________________________________________________________________|
Intestine Small | A A A + A A A + A A + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A A + A A A M A A + A M A + M + + + + M + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A A A A A A + A A + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A A + A A A + A A + A + A + A + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Pancreas | + + A + M A + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Adrenal Gland, Medulla | I I + M + + I + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + M I M A M + + M I + M I I M + I + I + I A I I|
__________________________________________________________________________|
Parathyroid Gland | M M M + + M M M I + I + + M + + + + + I M M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + M I + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|
| 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|
18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemangioma | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Uterus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma Adenosquamous | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + + + + + + A + + + + + + + A +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant Mixed | X |
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Mixed | X |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M I + M M M + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M + + + M + + + + + + M + I + + M + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M M M + + M M M M M + M M + M M + + M M|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|
| 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|
18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M A A + M M M M + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | M + + M + + M + + + + + + M + + + + I + + + M + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
Thoracic, Ganglioneuroma | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Hemangiosarcoma, Metastatic, Tissue | |
NOS | |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|
| 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|
18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + A + + + + + + A + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| |
| 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A |
18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + A + + + + + A + + M + A + + + + A| 29 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + A + + A + + + + + A + + + A + + + + + A| 36 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + A + + A + + + + + A + + + A A + + + + A| 34 |
Leiomyoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + A + + A + + + + + A + + I A A + + + + A| 32 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + M M + A + M + M + A + I M M + I + + + A| 27 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + A + + A + + + + + A + + + A + + + + + A| 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M A + A + + A + + + + + A + + + A A + + + + A| 27 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + A + + + + + A + A + A A + + + + A| 31 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + A + + + + + A + A + A + + + + + A| 31 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X | 4 |
Hepatocellular Adenoma | X X | 4 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + A| 44 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + I| 46 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + M + I + M I + M + + + + + I I + I I| 23 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + I + + + M M M + M + M M + + M I M + +| 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| |
| 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A |
18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
Hemangioma | X | 1 |
Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + I M + + M + + + + + +| 46 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma Adenosquamous | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + A| 45 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Axillary, Lymphoma Malignant Mixed | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| X | 1 |
Iliac, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Renal, Lymphoma Malignant Lymphocytic| X | 1 |
Renal, Lymphoma Malignant Mixed | | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + + + + + + +| 43 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| |
| 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A |
18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + + + + + M M M + + + + + M + + + + M| 36 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X | 3 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M M M + + M M + M M M M M M M + M M M + M M| 14 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + M + + A + + + + + M + + + + + + + + M +| 37 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + M + + + + + I +| 41 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + I + + + + + + + + + + + + + + + +| 48 |
Fibrosarcoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| |
| 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A |
18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Thoracic, Ganglioneuroma | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 2 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hemangiosarcoma, Metastatic, Tissue | | |
NOS | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + I + A + + + M + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenocarcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + A + + A + + + + + A + + + A + + + + + +| 41 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X X X | 3 |
Lymphoma Malignant Mixed | X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 1| 5| 1| 7| 1| 5| 5| 4| 7| 5| 5| 0| 1| 7| 7| 7| 7| 3| 5| 7| 5|
DAY ON TEST | 3| 3| 4| 6| 8| 4| 8| 1| 8| 4| 4| 0| 1| 4| 3| 2| 8| 3| 0| 3| 3| 6| 0| 3| 5|
| 2| 2| 9| 9| 5| 9| 5| 1| 6| 9| 9| 4| 5| 9| 2| 8| 6| 2| 1| 2| 2| 8| 4| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7|
CONTROL | 8| 9| 0| 3| 5| 7| 8| 6| 7| 8| 0| 2| 3| 4| 9| 6| 7| 8| 9| 7| 8| 9| 6| 8| 2|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + I + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + M + M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + M + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + M |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 1| 5| 1| 7| 1| 5| 5| 4| 7| 5| 5| 0| 1| 7| 7| 7| 7| 3| 5| 7| 5|
DAY ON TEST | 3| 3| 4| 6| 8| 4| 8| 1| 8| 4| 4| 0| 1| 4| 3| 2| 8| 3| 0| 3| 3| 6| 0| 3| 5|
| 2| 2| 9| 9| 5| 9| 5| 1| 6| 9| 9| 4| 5| 9| 2| 8| 6| 2| 1| 2| 2| 8| 4| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7|
CONTROL | 8| 9| 0| 3| 5| 7| 8| 6| 7| 8| 0| 2| 3| 4| 9| 6| 7| 8| 9| 7| 8| 9| 6| 8| 2|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + |
__________________________________________________________________________|
Skin | + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + |
Alveolar/Bronchiolar Adenoma | |
__________________________________________________________________________|
Nose | + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 1| 7| 3| 1| 3| 5| 1| 3| 1| 5| 3| 6| 5| 3| | |
DAY ON TEST | 8| 3| 6| 8| 6| 4| 8| 6| 8| 5| 6| 9| 7| 6| | |
| 6| 2| 8| 6| 9| 9| 7| 9| 7| 0| 9| 4| 6| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 7| 7| 9| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 4| | A |
CONTROL | 6| 7| 8| 9| 3| 6| 8| 0| 6| 2| 5| 6| 7| 0| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 11 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + | 11 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 11 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach | + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + M + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + | 11 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 1| 7| 3| 1| 3| 5| 1| 3| 1| 5| 3| 6| 5| 3| | |
DAY ON TEST | 8| 3| 6| 8| 6| 4| 8| 6| 8| 5| 6| 9| 7| 6| | |
| 6| 2| 8| 6| 9| 9| 7| 9| 7| 0| 9| 4| 6| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 7| 7| 9| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 4| | A |
CONTROL | 6| 7| 8| 9| 3| 6| 8| 0| 6| 2| 5| 6| 7| 0| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 11 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 11 |
__________________________________________________________________________|____________|
Lung | + + + + + | 11 |
Alveolar/Bronchiolar Adenoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + | 11 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 11 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 11 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 3| 5| 5| 3| 3| 7| 1| 7| 6| 3| 1| 1| 6| 5| 7| 7| 1| 5| 0| 6| 7| 1| 3| 0| 5|
DAY ON TEST | 6| 4| 4| 6| 6| 1| 8| 3| 5| 6| 8| 8| 5| 4| 3| 3| 8| 4| 1| 7| 3| 8| 6| 0| 2|
| 9| 9| 9| 8| 9| 7| 5| 2| 9| 8| 5| 6| 5| 9| 2| 2| 6| 9| 7| 8| 2| 7| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 4| 4| 4| 5| 5| 5| 7| 7| 8| 8| 8| 8| 8| 1| 1| 1| 1|
6 MG/M3 | 7| 8| 1| 3| 5| 6| 7| 8| 6| 8| 9| 1| 7| 9| 7| 9| 0| 2| 4| 6| 8| 0| 2| 3| 4|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + |
__________________________________________________________________________|
Gallbladder | + + + M + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M |
__________________________________________________________________________|
Intestine Small | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + |
__________________________________________________________________________|
Pancreas | + + + + + M + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + |
__________________________________________________________________________|
Parathyroid Gland | M + + M M M M M |
__________________________________________________________________________|
Pituitary Gland | + + + M M + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + M + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + |
Endometrium, Polyp | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + + + M |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + M + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 3| 5| 5| 3| 3| 7| 1| 7| 6| 3| 1| 1| 6| 5| 7| 7| 1| 5| 0| 6| 7| 1| 3| 0| 5|
DAY ON TEST | 6| 4| 4| 6| 6| 1| 8| 3| 5| 6| 8| 8| 5| 4| 3| 3| 8| 4| 1| 7| 3| 8| 6| 0| 2|
| 9| 9| 9| 8| 9| 7| 5| 2| 9| 8| 5| 6| 5| 9| 2| 2| 6| 9| 7| 8| 2| 7| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 4| 4| 4| 5| 5| 5| 7| 7| 8| 8| 8| 8| 8| 1| 1| 1| 1|
6 MG/M3 | 7| 8| 1| 3| 5| 6| 7| 8| 6| 8| 9| 1| 7| 9| 7| 9| 0| 2| 4| 6| 8| 0| 2| 3| 4|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + |
__________________________________________________________________________|
Nose | + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1| | |
DAY ON TEST | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8| | |
| 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| | A |
6 MG/M3 | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 11 |
__________________________________________________________________________|____________|
Gallbladder | + + + M | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + | 12 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 11 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | M + + + | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | I + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | M M + + | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | M M + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + | 11 |
__________________________________________________________________________|____________|
Uterus | + + + + | 12 |
Endometrium, Polyp | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1| | |
DAY ON TEST | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8| | |
| 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| | A |
6 MG/M3 | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + | 12 |
__________________________________________________________________________|____________|
Thymus | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 12 |
__________________________________________________________________________|____________|
Skin | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 12 |
__________________________________________________________________________|____________|
Lung | + + + + | 12 |
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | M + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 12 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 12 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 0| 0| 1| 7| 0| 0| 4| 3| 1| 7| 3| 5| 3| 7| 5| 1| 2| 3| 5| 1| 5| 1| 5| 7| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 9| 6| 8| 3| 6| 4| 6| 3| 0| 8| 8| 6| 4| 8| 4| 8| 4| 3| 3|
| 8| 8| 4| 2| 8| 8| 5| 9| 6| 2| 8| 6| 9| 2| 8| 5| 6| 8| 9| 7| 9| 5| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 5| 5| 6| 6| 6| 6| 6| 6| 8| 9| 9| 9|
18 MG/M3 | 7| 8| 9| 0| 5| 8| 9| 6| 0| 1| 3| 5| 7| 7| 8| 2| 3| 4| 5| 8| 9| 7| 1| 3| 5|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + |
__________________________________________________________________________|
Gallbladder | M M + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + |
__________________________________________________________________________|
Liver | + + + + |
Hepatocellular Adenoma | |
__________________________________________________________________________|
Pancreas | + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + I + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + |
__________________________________________________________________________|
Thyroid Gland | M + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + |
__________________________________________________________________________|
Uterus | + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | I M M M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 0| 0| 1| 7| 0| 0| 4| 3| 1| 7| 3| 5| 3| 7| 5| 1| 2| 3| 5| 1| 5| 1| 5| 7| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 9| 6| 8| 3| 6| 4| 6| 3| 0| 8| 8| 6| 4| 8| 4| 8| 4| 3| 3|
| 8| 8| 4| 2| 8| 8| 5| 9| 6| 2| 8| 6| 9| 2| 8| 5| 6| 8| 9| 7| 9| 5| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 5| 5| 6| 6| 6| 6| 6| 6| 8| 9| 9| 9|
18 MG/M3 | 7| 8| 9| 0| 5| 8| 9| 6| 0| 1| 3| 5| 7| 7| 8| 2| 3| 4| 5| 8| 9| 7| 1| 3| 5|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + |
__________________________________________________________________________|
Thymus | + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + |
__________________________________________________________________________|
Skin | + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + |
__________________________________________________________________________|
Lung | + + + + |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + |
Transitional Epithelium, Papilloma | |
__________________________________________________________________________|
Urinary Bladder | + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3| | |
DAY ON TEST | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6| | |
| 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5| | A |
18 MG/M3 | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M | 10 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 12 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M + + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3| | |
DAY ON TEST | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6| | |
| 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5| | A |
18 MG/M3 | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | I + + + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M M | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 12 |
Transitional Epithelium, Papilloma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|
| 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|
CONTROL | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + M + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | M + M + + A A + M + + + + + M A + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + A A + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A A + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A A + + + + + + + + A + + + + + + + A|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A A + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + A A + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A A + A + + + + + + A + + + + + + + A|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + + + + + + + + A + + + + + + + A|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A A + + + + + + + + A + + M + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + A|
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, Spleen | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | |
Hepatocellular Adenoma, Multiple | X |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + A + + + + + + + M|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + I + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Glandular | + + + + + M A + + + + + + + + A + + + + + + + A|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | I + + + + + M + + + + + + + + + + + + + + + + A|
Spindle Cell, Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Cortex | I + + + + + M + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + M M M + + + + + + + + + + + + + + + A|
Pheochromocytoma Malignant | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + M + + I M + + + A + M I + + I + M|
__________________________________________________________________________|
Parathyroid Gland | + M M M + M M M M + M + + M + + + + M M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + M|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|
| 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|
CONTROL | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + M + + M + + I + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + I + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Seminal Vesicle | + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + A + + + + + + + A|
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + A + + + A + + + + + + + A|
Hemangiosarcoma, Metastatic, Spleen | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + M|
Iliac, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Pancreatic, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Renal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M I + + + M + + + + + + M M + M|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M M + M + + M M M M + M M M + + + + M + + M|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M I + M M + + M M M M + M M M M M M M|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + I M + M + + + + + + + M + + + + + + + M|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A|
Hemangiosarcoma | X X |
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | M + + + + M + + I I + M + + + A + + + + + + + M|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M + + M M M + M M M M + M M M|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|
| 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|
CONTROL | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + I + + + + + I + + + + + A + + + + + + + A|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + A|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Carcinoma | X X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hemangiosarcoma, Metastatic, Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + M + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A|
Carcinoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + A|
Sarcoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | |
| 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + M + + + M + + + | 41 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + + A M + M A A + + A | 31 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + + + + A A + A A A + + + | 36 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + A + + A A + A A A + + A | 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + A A + A A A + + + | 36 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | I + A + + + + + + + A + M A A + A A A + + M | 32 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + A + + A A + A A A + + A | 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + M + A + + A A + A A A + + A | 32 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + A + A A A + A A A + + A | 33 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + A + A A A + A A A + + A | 32 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Hepatocellular Carcinoma | X X X | 6 |
Hepatocellular Adenoma | X | 1 |
Hepatocellular Adenoma, Multiple | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + | 42 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + M | 43 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + A + I + | 39 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + | 43 |
Spindle Cell, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + | 43 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + I | 39 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | |
| 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + I M + M I + I I + M I + + + + I A M + + | 26 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M + + + + + + M M M + M + + + + M + | 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + | 44 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + M + + M + + + + M + + M + + + + + + + | 39 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 8 |
__________________________________________________________________________|____________|
Prostate | M + M I + + + + + + + + + + M + + + + + + + | 40 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + A + + A A + + A | 41 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + M + + + + + + + | 43 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + + + + + + + + + + + + + + A + + + | 40 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Iliac, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Pancreatic, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
Renal, Lymphoma Malignant | | |
Undifferentiated Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + M + + + M I M + + I M M I | 32 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M M + + M + + + M + + + M M M M M + + M | 23 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M M M M M M + M M M + M M M M M + M M | 9 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + + + + I + M + + + M + + + A + + + | 36 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | |
| 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + | 44 |
Hemangiosarcoma | | 2 |
Lymphoma Malignant Mixed | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | I + M + + + + + + + + + I M M + + + + + + + | 34 |
Lymphoma Malignant Mixed | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M I M M M M M M M M M M I M M M | 5 |
__________________________________________________________________________|____________|
Skin | + I + + + + + + + + + + M + + + + + + + + + | 44 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + | 42 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Alveolar/Bronchiolar Adenoma | X X | 6 |
Alveolar/Bronchiolar Carcinoma | X X | 6 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Hemangiosarcoma, Metastatic, Liver | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Trachea | + + A + + + + + + + + + + + + + + A + + + + | 42 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + | 43 |
Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | |
| 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant Mixed | X X | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|
| 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|
6 MG/M3 | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + M + + + A + + A + A A + I + + + I + + I |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + A + A A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + A + + A + A A + + + + + + + + A |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + A + A A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + A I A M + + + + + + M + A |
__________________________________________________________________________|
Intestine Small | + + + A + + + A + + A + A A + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A M + + A + M A + A A + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + A + A A + A + + + + + + A |
Adenocarcinoma | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + A + + A + A A + + + + M + + + A |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + M + M M + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + A + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + A A + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + A A + + + + + + + + I |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + A A + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + M + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + A + + + + + + + + + + + + |
Spindle Cell, Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + A + + + + + + + + + + + + |
Adenoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | M M + + + + + + + + A + + + + + + + + + + + I |
__________________________________________________________________________|
Islets, Pancreatic | + M + A M I M + M + M I M M + M M + I + I + + |
__________________________________________________________________________|
Parathyroid Gland | M + M + M M M + + M M + M M + M + + I M I M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|
| 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|
6 MG/M3 | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + M + + I + A + + + + + + + + + M + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Preputial Gland | + + |
__________________________________________________________________________|
Prostate | + + + A + + + + + + + + + + + M + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Seminal Vesicle | + + + A + + + + + + A + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + A + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + I + + M M + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M M M + M + + + M + M + + + M M + M M M M |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M M M M + M M + M M M M M M M + M M M |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M M + + + M + + M + M + + M + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + A + + + + + + + + + |
__________________________________________________________________________|
Thymus | + + + M + + + + + + A + M + M M M I + + + M + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M M M M + M M M M M M M + M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + I + M + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + I + A + + + + + + A + A A + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|
| 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|
6 MG/M3 | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Liver | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A I + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + A + + A + A A + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5| | |
DAY ON TEST | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5| | |
| 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| | A |
6 MG/M3 | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + M A + + + A M M + A A + + A + + A | 29 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + A + + + A + + + A + + + + + + A | 38 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + A + + + A + A + A + + + + + + A | 35 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + A + + + A + + + A + + + + + + A | 38 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + A + + A + + + A + + + A M + + + + M A | 32 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + A + + + A A A + A + + + + + + A | 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + A + + + A A A + A + + A A + + A | 30 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + A + + + A A A + A + + + A + + A | 32 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + A + + + A A A + A A + + + M + A | 31 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Hepatocellular Carcinoma | X X | 5 |
Hepatocellular Adenoma | X X X | 8 |
Hepatocellular Adenoma, Multiple | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | I + + + + + + + M + + + + + A + + + + + + + + A | 39 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + A | 43 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + I + + + + + + + + + A | 41 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A | 43 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Spindle Cell, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Adenoma | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + I + + M M + + + + + + + + + + + + + + M + + | 39 |
__________________________________________________________________________|____________|
Islets, Pancreatic | I I I M I I I I M + I + + + A + M + + + + + + A | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5| | |
DAY ON TEST | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5| | |
| 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| | A |
6 MG/M3 | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + M M + + + + M M M + M + M M M + + I | 21 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + M + + + + + + + + | 44 |
Pars Intermedia, Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + I + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + I A + + + + + + + + + + + + I + + I + + | 39 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 6 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + I + + + + + + + + + + + + + + A | 43 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + A + + + + + + + + + + + + + + + + + A | 43 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + A + + + + + + + + + + + + + + + + + A | 44 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + A + + + A + + + A + + A + + + A | 42 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + M + + + + + + M + + + + + + M + | 39 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + M + + + M + + + M + M M + + M + M M M + | 23 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + M M M + M M M M + + M M M M M M M M + + | 10 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + M | 39 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A | 44 |
__________________________________________________________________________|____________|
Thymus | + + I + + I + + + + + M + + M + I + + + + + I + | 33 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M + M M M + M M M M M A | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 45 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5| | |
DAY ON TEST | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5| | |
| 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| | A |
6 MG/M3 | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + A | 41 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Alveolar/Bronchiolar Adenoma | X | 4 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A | 46 |
__________________________________________________________________________|____________|
Trachea | + + + + M + + + + + + + + + + + + + + + + + + A | 43 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A | 46 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + A + + + + + + + + + + A + + + + + + A | 38 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 50
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|
| 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|
18 MG/M3 | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M M + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + A M + + + A + + + A + A + + + A + + A + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + A + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + + + + + A + A + + + A + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + A + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + I M A M + + M + + + A + M + M I + + + A + + M|
__________________________________________________________________________|
Intestine Small | A + + A A + + + + + + + A + A + + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + M M A + + + + + + + A + A + + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A A + + + A + + + A + A + + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A A + + + + + + + A + A + + + A + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X X X X X |
Hepatocellular Adenoma | X X X |
__________________________________________________________________________|
Pancreas | + + M + + + + + + + I + + + + + + + + + + A + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Spindle Cell, Adenoma | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +|
Adenoma | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + I + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Islets, Pancreatic | I I M + I I I M + + I I + I + + + I + + + A + + M|
__________________________________________________________________________|
Parathyroid Gland | + + I M + + I M + M + M + + + M + + + + + A M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Thyroid Gland | + + + I + + + + + + + + + + + + + + + + + A + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemangioma | |
Hemangiosarcoma, Metastatic, Spleen | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + M + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|
| 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|
18 MG/M3 | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + |
__________________________________________________________________________|
Prostate | M + + + + + + + M + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Seminal Vesicle | M + + + + + + + M + + + + + + + + + M + + A + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A A + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + M + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
__________________________________________________________________________|
Lymph Node, Mandibular | I + + M M + + M I M M M + M M + + M M I M M + M +|
Hemangiosarcoma, Metastatic, Spleen | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M M M M M M M M M M + M M M + M + M M M M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + M + + + + + + A + + +|
Hemangiosarcoma, Metastatic, Spleen | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hemangiosarcoma | X X |
__________________________________________________________________________|
Thymus | M + + + + + + M + + + + + + + + + + M + + A + + M|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | I M + M I M M M M M M M M M + M + M M I M M + + I|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Spleen | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hemangiosarcoma, Metastatic, Spleen | X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|
| 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|
18 MG/M3 | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + + + A + I +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3| |
| 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| A |
18 MG/M3 | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Gallbladder | + I A + + M + M + + + + + A + + + + + + + + A +| 35 |
__________________________________________________________________________|____________|
Intestine Large | + + A + A A + A + + + + + + + + + + + + + + A +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + A A + A + + + + + A + + + + + + + + A +| 37 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + A A + A + + + + + A + + + + + + + + A +| 39 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A M A A + A + + + + M + + + + + + + + + A +| 31 |
__________________________________________________________________________|____________|
Intestine Small | + + A + A A + A + + + + + A + + + + + + + + A +| 36 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + A A + A + + + + + A + + + + + + M + A +| 34 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + A A + A + + + + + A + + + + + + + + A +| 35 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + A A + A + + + + + A + + + + + + + + A +| 36 |
__________________________________________________________________________|____________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X X X X | 11 |
Hepatocellular Adenoma | X | 4 |
__________________________________________________________________________|____________|
Pancreas | + + A + A A + A + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach | + + + + + A + A + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + A + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + A A + A + + + + + + + + + + + + + + A +| 43 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Spindle Cell, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + M A + + + + + + + I + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A M A A M A M + + I I + I + + + + + I M + +| 24 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M + + A M M M M M + M + + M + + + M + +| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + A + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A + + + I + + + + + + + + + + + +| 45 |
Follicular Cell, Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3| |
| 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| A |
18 MG/M3 | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
Hemangioma | X | 1 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + A + + A + + + + + + M + M + + + + + + M| 42 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 8 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + A + + + + + M + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Seminal Vesicle | + I A + A A + A + + + + + M + + + + + + + + + +| 39 |
__________________________________________________________________________|____________|
Testes | + + + + A M + A + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + A + A + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + A + + + + + M + + + + M + + + + +| 44 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + M M M A M M + M + + M + + M + M M + + M| 19 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + M M M M M M M M M M M M M M M + M M M M| 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | I + + + A + + A + + + + + M + + + + + + + + M M| 40 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Hemangiosarcoma | | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + M + + + + M + + I + +| 40 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + M M M M M M M M M M M M + M M M M M M M| 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + I + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Thoracic, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3| |
| 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| A |
18 MG/M3 | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + A + + A + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lung | + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Alveolar/Bronchiolar Adenoma | X X X X X| 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | X | 2 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Trachea | + + + + A M M A + + + + + + + + + + + + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Adenoma | X | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A A + A + + + + + + + + + + + + + + A +| 43 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 1| 1| 1| 7| 7| 5| 3| 3| 3| 7| 3| 7| 2| 1| 7| 7| 3| 6| 1| 5|
DAY ON TEST | 3| 4| 1| 3| 4| 8| 8| 8| 3| 3| 4| 6| 6| 6| 3| 6| 3| 9| 8| 3| 3| 6| 1| 8| 4|
| 9| 9| 5| 9| 9| 5| 5| 5| 9| 9| 9| 9| 8| 9| 9| 8| 9| 5| 5| 9| 9| 9| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 6| 6|
CONTROL | 2| 3| 5| 6| 8| 9| 3| 4| 7| 9| 0| 1| 4| 2| 8| 9| 0| 2| 3| 3| 6| 7| 9| 0| 1|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + I + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + +|
Hepatocellular Carcinoma | X X|
Hepatocellular Adenoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
Rhabdomyosarcoma, Metastatic, | |
Skeletal Muscle | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + M + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + M M + + + M +|
__________________________________________________________________________|
Testes | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 1| 1| 1| 7| 7| 5| 3| 3| 3| 7| 3| 7| 2| 1| 7| 7| 3| 6| 1| 5|
DAY ON TEST | 3| 4| 1| 3| 4| 8| 8| 8| 3| 3| 4| 6| 6| 6| 3| 6| 3| 9| 8| 3| 3| 6| 1| 8| 4|
| 9| 9| 5| 9| 9| 5| 5| 5| 9| 9| 9| 9| 8| 9| 9| 8| 9| 5| 5| 9| 9| 9| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 6| 6|
CONTROL | 2| 3| 5| 6| 8| 9| 3| 4| 7| 9| 0| 1| 4| 2| 8| 9| 0| 2| 3| 3| 6| 7| 9| 0| 1|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + M +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + M M + +|
Adenocarcinoma, Metastatic, Lung | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + M +|
__________________________________________________________________________|
Spleen | + + + + + + + +|
__________________________________________________________________________|
Thymus | + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Rhabdomyosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic | X |
Hepatocellular Carcinoma, Metastatic | X |
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7| | |
DAY ON TEST | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3| | |
| 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2| | A |
CONTROL | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 11 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + | 12 |
Hepatocellular Carcinoma | | 2 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 12 |
Rhabdomyosarcoma, Metastatic, | | |
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + I + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + I + | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 11 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 12 |
__________________________________________________________________________|____________|
Prostate | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7| | |
DAY ON TEST | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3| | |
| 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2| | A |
CONTROL | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + M + + | 8 |
__________________________________________________________________________|____________|
Testes | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 12 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M | 5 |
Adenocarcinoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + | 12 |
__________________________________________________________________________|____________|
Thymus | + + + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + | 3 |
__________________________________________________________________________|____________|
Skin | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 12 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Rhabdomyosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 12 |
__________________________________________________________________________|____________|
Lung | + + + + | 12 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic | | 1 |
Hepatocellular Carcinoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7| | |
DAY ON TEST | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3| | |
| 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2| | A |
CONTROL | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 12 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 12 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 1| 3| 1| 7| 7| 1| 5| 3| 7| 3| 5| 1| 7| 5| 3| 1| 5| 3| 7| 5| 5| 3| 5| 7| 1|
DAY ON TEST | 7| 6| 8| 3| 3| 8| 4| 6| 3| 6| 4| 8| 3| 4| 6| 8| 4| 6| 3| 4| 5| 6| 4| 3| 8|
| 6| 9| 5| 9| 9| 5| 9| 8| 9| 9| 9| 5| 9| 9| 8| 5| 9| 9| 9| 9| 0| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| 9| 0|
6 MG/M3 | 2| 3| 6| 9| 1| 2| 3| 1| 4| 7| 9| 3| 4| 5| 2| 3| 7| 9| 0| 3| 1| 4| 7| 8| 2|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M M + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + +|
Hepatocellular Adenoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + M M + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + M M + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + M M + + M + + + +|
__________________________________________________________________________|
Islets, Pancreatic | M + + + + M M + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + I + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + M + + M + + + + M|
__________________________________________________________________________|
Testes | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + I I + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 1| 3| 1| 7| 7| 1| 5| 3| 7| 3| 5| 1| 7| 5| 3| 1| 5| 3| 7| 5| 5| 3| 5| 7| 1|
DAY ON TEST | 7| 6| 8| 3| 3| 8| 4| 6| 3| 6| 4| 8| 3| 4| 6| 8| 4| 6| 3| 4| 5| 6| 4| 3| 8|
| 6| 9| 5| 9| 9| 5| 9| 8| 9| 9| 9| 5| 9| 9| 8| 5| 9| 9| 9| 9| 0| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| 9| 0|
6 MG/M3 | 2| 3| 6| 9| 1| 2| 3| 1| 4| 7| 9| 3| 4| 5| 2| 3| 7| 9| 0| 3| 1| 4| 7| 8| 2|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M M + M M + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M M + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
__________________________________________________________________________|
Thymus | + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | A |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1| | |
DAY ON TEST | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8| | |
| 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6| | A |
6 MG/M3 | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 12 |
__________________________________________________________________________|____________|
Liver | + + | 12 |
Hepatocellular Adenoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 12 |
__________________________________________________________________________|____________|
Prostate | + + | 12 |
__________________________________________________________________________|____________|
Seminal Vesicle | + M | 8 |
__________________________________________________________________________|____________|
Testes | + + | 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1| | |
DAY ON TEST | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8| | |
| 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6| | A |
6 MG/M3 | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 9 |
__________________________________________________________________________|____________|
Spleen | + + | 12 |
__________________________________________________________________________|____________|
Thymus | + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M | 3 |
__________________________________________________________________________|____________|
Skin | + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 12 |
__________________________________________________________________________|____________|
Lung | + + | 12 |
Alveolar/Bronchiolar Adenoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 12 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 12 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 1| 5| 5| 1| 1| 1| 7| 3| 5| 1| 3| 5| 1| 5| 5| 1| 7| 5| 7| 3| 1| 1| 1| 7| 5|
DAY ON TEST | 1| 4| 4| 1| 1| 8| 3| 6| 4| 8| 6| 4| 8| 6| 4| 8| 3| 5| 3| 6| 8| 4| 8| 3| 4|
| 3| 9| 9| 4| 4| 7| 9| 8| 9| 5| 8| 9| 5| 9| 9| 6| 9| 0| 9| 9| 6| 8| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 9| 9| 9| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 7| 7| 7|
18 MG/M3 | 1| 2| 8| 0| 1| 4| 2| 6| 8| 0| 2| 5| 3| 4| 5| 6| 7| 4| 1| 2| 3| 4| 5| 6| 8|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M|
__________________________________________________________________________|
Intestine Small | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + +|
Hepatocellular Adenoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + +|
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M M M M|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + M + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + M + M + M +|
__________________________________________________________________________|
Testes | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M M M M |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
_____________________________________________________________________________________________________________________
| 1| 5| 5| 1| 1| 1| 7| 3| 5| 1| 3| 5| 1| 5| 5| 1| 7| 5| 7| 3| 1| 1| 1| 7| 5|
DAY ON TEST | 1| 4| 4| 1| 1| 8| 3| 6| 4| 8| 6| 4| 8| 6| 4| 8| 3| 5| 3| 6| 8| 4| 8| 3| 4|
| 3| 9| 9| 4| 4| 7| 9| 8| 9| 5| 8| 9| 5| 9| 9| 6| 9| 0| 9| 9| 6| 8| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 9| 9| 9| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 7| 7| 7|
18 MG/M3 | 1| 2| 8| 0| 1| 4| 2| 6| 8| 0| 2| 5| 3| 4| 5| 6| 7| 4| 1| 2| 3| 4| 5| 6| 8|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + M + M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + M|
__________________________________________________________________________|
Spleen | M + + + + + + +|
__________________________________________________________________________|
Thymus | + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + +|
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + M + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3| | |
DAY ON TEST | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6| | |
| 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4| | A |
18 MG/M3 | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + M | 9 |
__________________________________________________________________________|____________|
Gallbladder | M + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + I | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + | 12 |
Hepatocellular Adenoma | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 11 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 12 |
__________________________________________________________________________|____________|
Prostate | + + + + | 12 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 8 |
__________________________________________________________________________|____________|
Testes | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05079-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:42:04
__________________________________________________________________________________________________________________________________
| 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3| | |
DAY ON TEST | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6| | |
| 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4| | A |
18 MG/M3 | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + M | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + | 11 |
__________________________________________________________________________|____________|
Thymus | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 12 |
__________________________________________________________________________|____________|
Lung | + + + + | 12 |
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + M + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 12 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 12 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------