TDMS Study 05079-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TALC
NTP Experiment-Test: 05079-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 14807966
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 39 50 40 50 40
Scheduled Sacrifice 30 30 29
Early Deaths
Natural Death 17 7 21 5 21 10
Moribund Sacrifice 2 2 4 5 4 1
Survivors
Terminal Sacrifice 30 23 25
Missing 1 1
Culled 1
Animals Examined Microscopically 46 11 49 12 50 12
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (43) (11) (48) (11) (48) (10)
Gallbladder (31) (10) (29) (10) (29) (9)
Intestine Large, Cecum (35) (11) (30) (12) (34) (12)
Leiomyoma 1 (3%)
Intestine Large, Colon (38) (11) (34) (12) (32) (12)
Leiomyosarcoma 1 (3%)
Intestine Small, Ileum (33) (11) (28) (12) (31) (12)
Liver (46) (11) (47) (12) (50) (12)
Hemangioma 1 (2%)
Hepatocellular Carcinoma 7 (15%) 5 (11%) 4 (8%)
Hepatocellular Adenoma 5 (11%) 1 (2%) 4 (8%) 1 (8%)
Mesentery (2)
Pancreas (42) (11) (40) (11) (44) (12)
Salivary Glands (46) (11) (49) (12) (50) (12)
Hemangioma 1 (2%)
Stomach, Glandular (45) (10) (40) (12) (46) (12)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (46) (11) (49) (11) (50) (12)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (46) (11) (46) (12) (50) (12)
Spindle Cell, Adenoma 1 (2%)
Adrenal Gland, Cortex (46) (11) (45) (11) (50) (12)
Adenoma 1 (2%)
Adrenal Gland, Medulla (41) (10) (44) (10) (45) (11)
Pheochromocytoma Malignant 1 (2%)
Pituitary Gland (42) (10) (43) (8) (48) (12)
Adenoma 5 (12%) 4 (9%) 2 (4%)
Carcinoma 2 (5%)
Thyroid Gland (43) (9) (48) (9) (49) (11)
Follicular Cell, Adenoma 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4) (3) (1) (4) (2) (4)
Fibrosarcoma 1 (25%)
Hemangioma 1 (25%) 1 (50%)
Hemangiosarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (38) (11) (43) (11) (46) (12)
Adenocarcinoma, Metastatic, Uterus 1 (3%)
Adenoma 1 (3%) 1 (2%)
Cystadenoma 1 (2%)
Luteoma 2 (5%)
Uterus (44) (11) (46) (12) (49) (12)
Adenocarcinoma 1 (2%)
Carcinoma Adenosquamous 1 (2%)
Endometrium, Polyp 1 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (41) (11) (44) (12) (45) (11)
Lymph Node (46) (11) (47) (12) (49) (12)
Lymph Node, Bronchial (38) (9) (37) (6) (43) (11)
Adenocarcinoma, Metastatic, Kidney 1 (3%)
Adenocarcinoma, Metastatic, Uterus 1 (3%)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 3 (8%)
Lymph Node, Mandibular (35) (7) (38) (11) (36) (11)
Lymph Node, Mediastinal (13) (5) (17) (5) (14)
Adenocarcinoma, Metastatic, Kidney 1 (6%)
Page 3
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (6%)
Lymph Node, Mesenteric (35) (11) (32) (11) (37) (10)
Spleen (45) (11) (45) (12) (50) (12)
Hemangiosarcoma 1 (2%)
Thymus (40) (11) (41) (12) (41) (12)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (41) (10) (45) (12) (48) (12)
Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (46) (11) (49) (12) (50) (12)
Vertebra, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Spinal Cord (1)
Thoracic, Ganglioneuroma 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (46) (11) (49) (12) (50) (12)
Adenocarcinoma, Metastatic, Kidney 1 (2%)
Alveolar/Bronchiolar Adenoma 3 (7%) 1 (9%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 2 (4%) 4 (8%) 1 (2%)
Hemangiosarcoma, Metastatic, Tissue NOS 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 2 (4%)
Trachea (40) (11) (37) (11) (45) (12)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (2) (1)
Adenocarcinoma 1 (100%)
Adenoma 2 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (46) (11) (47) (12) (50) (12)
Adenocarcinoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Transitional Epithelium, Papilloma 1 (8%)
Urinary Bladder (44) (11) (41) (12) (41) (12)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(46) *(11) *(49) *(12) *(50) *(12)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 2 (4%) 3 (6%) 3 (6%)
Lymphoma Malignant Mixed 3 (7%) 4 (8%) 2 (4%)
Lymphoma Malignant Undifferentiated Cell 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTOL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 31 1 26 1 21 1
Total Primary Neoplasms 42 1 33 1 31 2
Total Animals with Benign Neoplasms 18 1 9 1 10 1
Total Benign Neoplasms 23 1 13 1 13 2
Total Animals with Malignant Neoplasms 19 19 15
Total Malignant Neoplasms 19 20 18
Total Animals with Metastatic Neoplasms 3 5 1
Total Metastatic Neoplasm 5 13 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 49 39 49 40 50 40
Scheduled Sacrifice 35 33 31
Early Deaths
Natural Death 16 4 18 5 14 7
Moribund Sacrifice 1 2 1 3 1
Survivors
Terminal Sacrifice 30 28 32
Missing 1
Animals Examined Microscopically 46 12 47 12 49 12
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (31) (12) (29) (11) (35) (11)
Intestine Large, Colon (36) (12) (38) (12) (39) (12)
Intestine Small, Duodenum (32) (12) (30) (12) (34) (12)
Intestine Small, Ileum (33) (12) (32) (11) (35) (12)
Adenocarcinoma 1 (3%)
Liver (45) (12) (47) (12) (48) (12)
Hemangiosarcoma 1 (2%) 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatocellular Carcinoma 6 (13%) 2 (17%) 5 (11%) 11 (23%)
Hepatocellular Adenoma 1 (2%) 1 (8%) 8 (17%) 1 (8%) 4 (8%) 2 (17%)
Hepatocellular Adenoma, Multiple 2 (4%) 1 (2%)
Pancreas (42) (12) (39) (12) (42) (12)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Salivary Glands (45) (12) (46) (12) (47) (12)
Stomach, Glandular (39) (12) (43) (12) (43) (12)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (45) (12) (46) (12) (49) (12)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Rhabdomyosarcoma, Metastatic, Skeletal Muscle 1 (8%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (43) (12) (46) (10) (47) (12)
Spindle Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
Adrenal Gland, Cortex (43) (11) (46) (10) (47) (11)
Adenoma 1 (2%) 1 (2%)
Adrenal Gland, Medulla (39) (11) (39) (9) (42) (9)
Pheochromocytoma Malignant 1 (3%)
Pituitary Gland (44) (11) (44) (9) (46) (11)
Adenoma 1 (2%)
Pars Intermedia, Adenoma 2 (5%)
Thyroid Gland (45) (11) (46) (12) (45) (11)
Follicular Cell, Adenoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4) (3) (4) (2) (5)
Hemangioma 1 (50%)
Hemangiosarcoma, Metastatic, Spleen 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (39) (12) (39) (12) (42) (12)
Prostate (40) (12) (43) (12) (44) (12)
Seminal Vesicle (41) (8) (43) (8) (39) (8)
Testes (43) (12) (44) (12) (45) (12)
Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (40) (12) (42) (12) (43) (12)
Hemangiosarcoma, Metastatic, Spleen 1 (3%)
Lymph Node (45) (12) (46) (12) (48) (12)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (8%)
Lymph Node, Bronchial (32) (9) (39) (9) (44) (10)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Lymph Node, Mandibular (23) (6) (23) (9) (19) (4)
Hemangiosarcoma, Metastatic, Spleen 1 (5%)
Lymph Node, Mediastinal (9) (5) (10) (4) (7) (3)
Adenocarcinoma, Metastatic, Lung 1 (20%)
Lymph Node, Mesenteric (36) (10) (39) (9) (40) (10)
Hemangiosarcoma, Metastatic, Spleen 1 (3%)
Spleen (44) (12) (44) (12) (47) (11)
Page 8
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Hemangiosarcoma 2 (5%) 2 (4%)
Thymus (34) (11) (33) (11) (40) (12)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (46) (12) (47) (12) (49) (12)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Skeletal Muscle (1) (1)
Rhabdomyosarcoma 1 (100%)
Thoracic, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (45) (12) (47) (12) (48) (12)
Alveolar/Bronchiolar Adenoma 6 (13%) 4 (9%) 1 (8%) 7 (15%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (4%)
Alveolar/Bronchiolar Carcinoma 6 (13%) 1 (8%) 2 (4%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Alveolar/Bronchiolar Carcinoma, Metastatic 1 (8%)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatocellular Carcinoma, Metastatic 1 (8%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (4)
Adenoma 1 (100%) 4 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (45) (12) (46) (12) (48) (12)
Carcinoma, Metastatic, Uncertain Primary Site 1 (2%)
Urinary Bladder (43) (12) (38) (12) (43) (12)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(46) *(12) *(47) *(12) *(49) *(12)
Lymphoma Malignant Lymphocytic 1 (2%)
Lymphoma Malignant Mixed 2 (4%)
Lymphoma Malignant Undifferentiated Cell 3 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05079-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:21:53
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 26 3 20 2 28 2
Total Primary Neoplasms 36 5 26 2 38 2
Total Animals with Benign Neoplasms 11 1 16 2 18 2
Total Benign Neoplasms 12 1 17 2 22 2
Total Animals with Malignant Neoplasms 20 2 8 15
Total Malignant Neoplasms 24 4 9 16
Total Animals with Metastatic Neoplasms 4 1 1 4
Total Metastatic Neoplasm 5 5 1 11
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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