TDMS Study 05079-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: LITRI TALC DATE: 09/10/94
EXPERIMENT: 05079 TEST: 02 TIME: 17:34:05
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 06008
PATHOLOGIST: B. JONES F. HAHN CAS: 14807966
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: LITRI TALC DATE: 09/10/94
EXPERIMENT: 05079 TEST: 02 TIME: 17:34:05
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 06008
PATHOLOGIST: B. JONES F. HAHN CAS: 14807966
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: LITRI TALC DATE: 09/10/94
EXPERIMENT: 05079 TEST: 02 TIME: 17:34:05
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 06008
PATHOLOGIST: B. JONES F. HAHN CAS: 14807966
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF TALC
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Carcinoma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Malignant Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/58 (2%) 0/59 (0%) 4/61 (7%) | 2/57 (4%) 1/61 (2%) 0/62 (0%) |
|ADJUSTED (b) | 3.3% 0.0% 12.0% | 6.7% 4.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 1/30 (3%) 0/28 (0%) 3/32 (9%) | 2/30 (7%) 1/23 (4%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- 725 | 729 (T) 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073 P=0.514N P=0.204 | P=0.207N P=0.593N P=0.279N |
|INCIDENTAL TUMOR | P=0.080 P=0.514N P=0.239 | P=0.207N P=0.593N P=0.279N |
|LOGISTIC REGRESSION | P=0.075 P=0.514N P=0.216 | P=0.207N P=0.593N P=0.279N |
|COCHRAN-ARMITAGE | P=0.064 | P=0.162N |
|FISHER EXACT | P=0.496N P=0.198 | P=0.474N P=0.227N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/58 (2%) 0/59 (0%) 4/61 (7%) | 2/57 (4%) 1/61 (2%) 1/62 (2%) |
|ADJUSTED (b) | 3.3% 0.0% 12.0% | 6.7% 4.3% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 1/30 (3%) 0/28 (0%) 3/32 (9%) | 2/30 (7%) 1/23 (4%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- 725 | 729 (T) 729 (T) 706 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073 P=0.514N P=0.204 | P=0.490N P=0.593N P=0.554N |
|INCIDENTAL TUMOR | P=0.080 P=0.514N P=0.239 | P=0.453N P=0.593N P=0.476N |
|LOGISTIC REGRESSION | P=0.075 P=0.514N P=0.216 | P=0.479N P=0.593N P=0.536N |
|COCHRAN-ARMITAGE | P=0.064 | P=0.421N |
|FISHER EXACT | P=0.496N P=0.198 | P=0.474N P=0.468N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/57 (7%) 10/59 (17%) 6/60 (10%) | 5/57 (9%) 1/59 (2%) 5/62 (8%) |
|ADJUSTED (b) | 11.7% 30.8% 15.2% | 16.7% 4.3% 16.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/4 (25%) 1/4 (25%) 2/4 (50%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 1/4 (25%) |
|TERMINAL (d) | 3/30 (10%) 7/28 (25%) 3/32 (9%) | 5/30 (17%) 1/23 (4%) 2/25 (8%) |
|FIRST INCIDENCE (DAYS) | 369 (I) 369 (I) 369 (I) | 729 (T) 729 (T) 549 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.535 P=0.063 P=0.399 | P=0.399 P=0.169N P=0.535 |
|INCIDENTAL TUMOR | P=0.514 P=0.080 P=0.436 | P=0.446 P=0.169N P=0.629 |
|LOGISTIC REGRESSION | P=0.499 P=0.082 P=0.398 | P=0.440 P=0.169N P=0.602 |
|COCHRAN-ARMITAGE | P=0.512 | P=0.514 |
|FISHER EXACT | P=0.087 P=0.404 | P=0.095N P=0.574N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/57 (14%) 5/59 (8%) 11/60 (18%) | 7/57 (12%) 5/59 (8%) 4/62 (6%) |
|ADJUSTED (b) | 20.6% 13.5% 26.7% | 18.7% 18.4% 15.4% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 2/4 (50%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 2/30 (7%) 1/28 (4%) 5/32 (16%) | 3/30 (10%) 3/23 (13%) 3/25 (12%) |
|FIRST INCIDENCE (DAYS) | 549 (I) 546 438 | 426 645 718 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.236 P=0.280N P=0.354 | P=0.308N P=0.487N P=0.344N |
|INCIDENTAL TUMOR | P=0.073 P=0.193N P=0.118 | P=0.271N P=0.392N P=0.306N |
|LOGISTIC REGRESSION | P=0.079 P=0.211N P=0.153 | P=0.255N P=0.387N P=0.273N |
|COCHRAN-ARMITAGE | P=0.219 | P=0.200N |
|FISHER EXACT | P=0.257N P=0.353 | P=0.357N P=0.218N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/57 (21%) 14/59 (24%) 16/60 (27%) | 11/57 (19%) 6/59 (10%) 8/62 (13%) |
|ADJUSTED (b) | 30.4% 39.2% 36.5% | 30.8% 22.5% 27.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/4 (25%) 1/4 (25%) 2/4 (50%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 2/4 (50%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 1/4 (25%) |
|TERMINAL (d) | 5/30 (17%) 8/28 (29%) 7/32 (22%) | 7/30 (23%) 4/23 (17%) 5/25 (20%) |
|FIRST INCIDENCE (DAYS) | 369 (I) 369 (I) 369 (I) | 426 645 549 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.315 P=0.395 P=0.316 | P=0.440N P=0.262N P=0.428N |
|INCIDENTAL TUMOR | P=0.170 P=0.479 P=0.136 | P=0.395N P=0.190N P=0.365N |
|LOGISTIC REGRESSION | P=0.164 P=0.440 P=0.155 | P=0.368N P=0.156N P=0.329N |
|COCHRAN-ARMITAGE | P=0.287 | P=0.279N |
|FISHER EXACT | P=0.451 P=0.311 | P=0.130N P=0.242N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/57 (21%) 14/59 (24%) 16/60 (27%) | 11/57 (19%) 6/59 (10%) 8/62 (13%) |
|ADJUSTED (b) | 30.4% 39.2% 36.5% | 30.8% 22.5% 27.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/4 (25%) 1/4 (25%) 2/4 (50%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 2/4 (50%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 1/4 (25%) |
|TERMINAL (d) | 5/30 (17%) 8/28 (29%) 7/32 (22%) | 7/30 (23%) 4/23 (17%) 5/25 (20%) |
|FIRST INCIDENCE (DAYS) | 369 (I) 369 (I) 369 (I) | 426 645 549 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.315 P=0.395 P=0.316 | P=0.440N P=0.262N P=0.428N |
|INCIDENTAL TUMOR | P=0.170 P=0.479 P=0.136 | P=0.395N P=0.190N P=0.365N |
|LOGISTIC REGRESSION | P=0.164 P=0.440 P=0.155 | P=0.368N P=0.156N P=0.329N |
|COCHRAN-ARMITAGE | P=0.287 | P=0.279N |
|FISHER EXACT | P=0.451 P=0.311 | P=0.130N P=0.242N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/57 (11%) 5/59 (8%) 9/60 (15%) | 4/57 (7%) 2/61 (3%) 2/62 (3%) |
|ADJUSTED (b) | 20.0% 16.1% 27.0% | 12.1% 6.7% 6.2% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 1/4 (25%) 0/4 (0%) | 1/4 (25%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 6/30 (20%) 4/28 (14%) 8/32 (25%) | 3/30 (10%) 1/23 (4%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 549 (I) 672 | 549 (I) 559 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.250 P=0.545N P=0.333 | P=0.356N P=0.415N P=0.392N |
|INCIDENTAL TUMOR | P=0.263 P=0.545N P=0.362 | P=0.311N P=0.346N P=0.341N |
|LOGISTIC REGRESSION | P=0.259 P=0.485N P=0.373 | P=0.322N P=0.331N P=0.347N |
|COCHRAN-ARMITAGE | P=0.233 | P=0.283N |
|FISHER EXACT | P=0.476N P=0.329 | P=0.308N P=0.301N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/57 (14%) 2/59 (3%) 2/60 (3%) | 2/57 (4%) 4/61 (7%) 1/62 (2%) |
|ADJUSTED (b) | 25.1% 5.9% 5.1% | 6.7% 11.4% 2.6% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/4 (25%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 7/30 (23%) 1/28 (4%) 0/32 (0%) | 2/30 (7%) 0/23 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 549 (I) 558 438 | 729 (T) 491 558 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.041N* P=0.057N P=0.042N* | P=0.383N P=0.286 P=0.539N |
|INCIDENTAL TUMOR | P=0.047N* P=0.052N P=0.036N* | P=0.311N P=0.428 P=0.464N |
|LOGISTIC REGRESSION | P=0.040N* P=0.043N* P=0.041N* | P=0.343N P=0.344 P=0.509N |
|COCHRAN-ARMITAGE | P=0.040N* | P=0.310N |
|FISHER EXACT | P=0.042N* P=0.039N* | P=0.373 P=0.468N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/57 (23%) 6/59 (10%) 11/60 (18%) | 6/57 (11%) 6/61 (10%) 3/62 (5%) |
|ADJUSTED (b) | 41.4% 18.2% 30.7% | 18.7% 17.4% 8.7% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 1/4 (25%) 1/4 (25%) 0/4 (0%) | 1/4 (25%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 12/30 (40%) 4/28 (14%) 8/32 (25%) | 5/30 (17%) 1/23 (4%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 549 (I) 549 (I) 438 | 549 (I) 491 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.424N P=0.075N P=0.338N | P=0.246N P=0.516 P=0.303N |
|INCIDENTAL TUMOR | P=0.436N P=0.071N P=0.297N | P=0.176N P=0.560N P=0.226N |
|LOGISTIC REGRESSION | P=0.439N P=0.052N P=0.329N | P=0.199N P=0.611N P=0.253N |
|COCHRAN-ARMITAGE | P=0.453N | P=0.161N |
|FISHER EXACT | P=0.056N P=0.356N | P=0.570N P=0.205N |
|=================================================================================================================================|
| |
|Ovary |
| Luteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/49 (4%) 0/55 (0%) 0/58 (0%) |
|ADJUSTED (b) | | 8.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | | 2/25 (8%) 0/21 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | | 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.177N P=0.277N P=0.246N |
|INCIDENTAL TUMOR | | P=0.177N P=0.277N P=0.246N |
|LOGISTIC REGRESSION | | P=0.177N P=0.277N P=0.246N |
|COCHRAN-ARMITAGE | | P=0.149N |
|FISHER EXACT | | P=0.220N P=0.207N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/56 (2%) 0/56 (0%) 0/58 (0%) | 5/53 (9%) 4/55 (7%) 2/60 (3%) |
|ADJUSTED (b) | 2.8% 0.0% 0.0% | 15.1% 18.2% 7.1% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 0/29 (0%) 0/27 (0%) 0/32 (0%) | 2/30 (7%) 4/22 (18%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 587 --- --- | 683 729 (T) 665 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.388N P=0.484N P=0.489N | P=0.239N P=0.610 P=0.290N |
|INCIDENTAL TUMOR | P=0.807N P=0.443N (e) | P=0.145N P=0.533N P=0.114N |
|LOGISTIC REGRESSION | P=0.387N P=0.500N P=0.491N | P=0.193N P=0.611N P=0.229N |
|COCHRAN-ARMITAGE | P=0.389N | P=0.139N |
|FISHER EXACT | P=0.500N P=0.491N | P=0.476N P=0.171N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/56 (0%) 0/56 (0%) 0/58 (0%) | 0/53 (0%) 2/55 (4%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 5.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 0/29 (0%) 0/27 (0%) 0/32 (0%) | 0/30 (0%) 0/22 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 534 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.591N P=0.236 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.576N P=0.263 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.551N P=0.244 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.546N |
|FISHER EXACT | (e) (e) | P=0.257 (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/56 (2%) 0/56 (0%) 0/58 (0%) | 5/53 (9%) 6/55 (11%) 2/60 (3%) |
|ADJUSTED (b) | 2.8% 0.0% 0.0% | 15.1% 22.5% 7.1% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 0/29 (0%) 0/27 (0%) 0/32 (0%) | 2/30 (7%) 4/22 (18%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 587 --- --- | 683 534 665 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.388N P=0.484N P=0.489N | P=0.216N P=0.352 P=0.290N |
|INCIDENTAL TUMOR | P=0.807N P=0.443N (e) | P=0.126N P=0.485 P=0.114N |
|LOGISTIC REGRESSION | P=0.387N P=0.500N P=0.491N | P=0.159N P=0.429 P=0.229N |
|COCHRAN-ARMITAGE | P=0.389N | P=0.117N |
|FISHER EXACT | P=0.500N P=0.491N | P=0.526 P=0.171N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/56 (0%) 2/56 (4%) 0/58 (0%) | 0/53 (0%) 0/55 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 6.5% 0.0% | 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 0/29 (0%) 1/27 (4%) 0/32 (0%) | 0/30 (0%) 0/22 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | --- 681 --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.547N P=0.238 (e) | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.523N P=0.305 (e) | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.560N P=0.240 (e) | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.566N | (e) |
|FISHER EXACT | P=0.248 (e) | (e) (e) |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/56 (4%) 0/56 (0%) 2/59 (3%) | 0/56 (0%) 0/57 (0%) 1/62 (2%) |
|ADJUSTED (b) | 6.9% 0.0% 5.5% | 0.0% 0.0% 4.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 2/29 (7%) 0/28 (0%) 0/32 (0%) | 0/30 (0%) 0/23 (0%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- 672 | --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.595 P=0.246N P=0.650N | P=0.278 (e) P=0.464 |
|INCIDENTAL TUMOR | P=0.658 P=0.246N P=0.550N | P=0.278 (e) P=0.464 |
|LOGISTIC REGRESSION | P=0.588 P=0.246N P=0.659N | P=0.278 (e) P=0.464 |
|COCHRAN-ARMITAGE | P=0.572 | P=0.313 |
|FISHER EXACT | P=0.248N P=0.671N | (e) P=0.525 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/57 (0%) 0/58 (0%) 2/57 (4%) | 1/54 (2%) 2/60 (3%) 2/61 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 6.5% | 3.4% 8.7% 8.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 0/30 (0%) 0/28 (0%) 2/31 (6%) | 1/29 (3%) 2/23 (9%) 2/25 (8%) |
|FIRST INCIDENCE (DAYS) | --- --- 736 (T) | 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.100 (e) P=0.245 | P=0.409 P=0.419 P=0.448 |
|INCIDENTAL TUMOR | P=0.100 (e) P=0.245 | P=0.409 P=0.419 P=0.448 |
|LOGISTIC REGRESSION | P=0.100 (e) P=0.245 | P=0.409 P=0.419 P=0.448 |
|COCHRAN-ARMITAGE | P=0.091 | P=0.492 |
|FISHER EXACT | (e) P=0.248 | P=0.540 P=0.546 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/58 (0%) 0/59 (0%) 1/61 (2%) | 2/57 (4%) 1/61 (2%) 1/62 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 3.1% | 6.7% 4.3% 4.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 0/30 (0%) 0/28 (0%) 1/32 (3%) | 2/30 (7%) 1/23 (4%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- 736 (T) | 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.312 (e) P=0.513 | P=0.496N P=0.593N P=0.564N |
|INCIDENTAL TUMOR | P=0.312 (e) P=0.513 | P=0.496N P=0.593N P=0.564N |
|LOGISTIC REGRESSION | P=0.312 (e) P=0.513 | P=0.496N P=0.593N P=0.564N |
|COCHRAN-ARMITAGE | P=0.304 | P=0.421N |
|FISHER EXACT | (e) P=0.513 | P=0.474N P=0.468N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/58 (7%) 0/59 (0%) 3/61 (5%) | 0/57 (0%) 0/61 (0%) 2/62 (3%) |
|ADJUSTED (b) | 12.9% 0.0% 8.4% | 0.0% 0.0% 6.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 3/30 (10%) 0/28 (0%) 1/32 (3%) | 0/30 (0%) 0/23 (0%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 710 --- 672 | --- --- 473 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.529N P=0.071N P=0.448N | P=0.086 (e) P=0.220 |
|INCIDENTAL TUMOR | P=0.461N P=0.048N* P=0.320N | P=0.051 (e) P=0.135 |
|LOGISTIC REGRESSION | P=0.539N P=0.060N P=0.450N | P=0.095 (e) P=0.248 |
|COCHRAN-ARMITAGE | P=0.559N | P=0.099 |
|FISHER EXACT | P=0.057N P=0.472N | (e) P=0.269 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/58 (7%) 0/59 (0%) 4/61 (7%) | 2/57 (4%) 1/61 (2%) 3/62 (5%) |
|ADJUSTED (b) | 12.9% 0.0% 11.4% | 6.7% 4.3% 10.0% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 3/30 (10%) 0/28 (0%) 2/32 (6%) | 2/30 (7%) 1/23 (4%) 2/25 (8%) |
|FIRST INCIDENCE (DAYS) | 710 --- 672 | 729 (T) 729 (T) 473 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.515 P=0.071N P=0.590N | P=0.323 P=0.593N P=0.434 |
|INCIDENTAL TUMOR | P=0.581 P=0.048N* P=0.475N | P=0.275 P=0.593N P=0.361 |
|LOGISTIC REGRESSION | P=0.510 P=0.060N P=0.592N | P=0.352 P=0.593N P=0.486 |
|COCHRAN-ARMITAGE | P=0.486 | P=0.399 |
|FISHER EXACT | P=0.057N P=0.613N | P=0.474N P=0.540 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/58 (9%) 1/59 (2%) 0/61 (0%) | 7/57 (12%) 7/61 (11%) 8/62 (13%) |
|ADJUSTED (b) | 16.7% 3.6% 0.0% | 21.1% 26.7% 27.4% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 5/30 (17%) 1/28 (4%) 0/32 (0%) | 5/30 (17%) 5/23 (22%) 5/25 (20%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) --- | 509 628 642 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.019N* P=0.116N P=0.027N* | P=0.358 P=0.454 P=0.387 |
|INCIDENTAL TUMOR | P=0.019N* P=0.116N P=0.027N* | P=0.419 P=0.572 P=0.487 |
|LOGISTIC REGRESSION | P=0.019N* P=0.116N P=0.027N* | P=0.401 P=0.592 P=0.456 |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.514 |
|FISHER EXACT | P=0.099N P=0.025N* | P=0.558N P=0.570 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/58 (9%) 1/59 (2%) 0/61 (0%) | 7/57 (12%) 7/61 (11%) 8/62 (13%) |
|ADJUSTED (b) | 16.7% 3.6% 0.0% | 21.1% 26.7% 27.4% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 5/30 (17%) 1/28 (4%) 0/32 (0%) | 5/30 (17%) 5/23 (22%) 5/25 (20%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) --- | 509 628 642 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.019N* P=0.116N P=0.027N* | P=0.358 P=0.454 P=0.387 |
|INCIDENTAL TUMOR | P=0.019N* P=0.116N P=0.027N* | P=0.419 P=0.572 P=0.487 |
|LOGISTIC REGRESSION | P=0.019N* P=0.116N P=0.027N* | P=0.401 P=0.592 P=0.456 |
|COCHRAN-ARMITAGE | P=0.021N* | P=0.514 |
|FISHER EXACT | P=0.099N P=0.025N* | P=0.558N P=0.570 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 12/58 (21%) 18/59 (31%) 20/61 (33%) | 19/57 (33%) 10/61 (16%) 11/62 (18%) |
|ADJUSTED (b) | 36.4% 53.1% 53.2% | 55.6% 37.6% 34.4% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/4 (25%) 1/4 (25%) 2/4 (50%) | 0/3 (0%) 1/4 (25%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/4 (0%) 1/4 (25%) 0/4 (0%) | 1/4 (25%) 0/4 (0%) 1/4 (25%) |
|TERMINAL (d) | 10/30 (33%) 13/28 (46%) 15/32 (47%) | 15/30 (50%) 8/23 (35%) 6/25 (24%) |
|FIRST INCIDENCE (DAYS) | 369 (I) 369 (I) 369 (I) | 549 (I) 369 (I) 548 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.130 P=0.106 P=0.097 | P=0.156N P=0.131N P=0.155N |
|INCIDENTAL TUMOR | P=0.110 P=0.141 P=0.092 | P=0.091N P=0.058N P=0.052N |
|LOGISTIC REGRESSION | P=0.100 P=0.151 P=0.088 | P=0.100N P=0.039N* P=0.077N |
|COCHRAN-ARMITAGE | P=0.115 | P=0.059N |
|FISHER EXACT | P=0.158 P=0.100 | P=0.027N* P=0.040N* |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 6 MG/M3 18 MG/M3 | CONTROL 6 MG/M3 18 MG/M3 |
| | LUNG TOX LUNG TOX LUNG TOX | LUNG TOX LUNG TOX LUNG TOX |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 22/58 (38%) 8/59 (14%) 15/61 (25%) | 19/57 (33%) 19/61 (31%) 15/62 (24%) |
|ADJUSTED (b) | 60.3% 23.1% 35.3% | 51.6% 55.2% 45.5% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/3 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 2/4 (50%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|TERMINAL (d) | 16/30 (53%) 4/28 (14%) 6/32 (19%) | 13/30 (43%) 9/23 (39%) 8/25 (32%) |
|FIRST INCIDENCE (DAYS) | 549 (I) 546 438 | 426 491 473 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.160N P=0.005N** P=0.095N | P=0.372N P=0.339 P=0.441N |
|INCIDENTAL TUMOR | P=0.207N P=0.002N** P=0.121N | P=0.275N P=0.586N P=0.314N |
|LOGISTIC REGRESSION | P=0.232N P=0.002N** P=0.082N | P=0.258N P=0.573N P=0.300N |
|COCHRAN-ARMITAGE | P=0.161N | P=0.156N |
|FISHER EXACT | P=0.002N** P=0.085N | P=0.477N P=0.184N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 29/58 (50%) 22/59 (37%) 30/61 (49%) | 32/57 (56%) 27/61 (44%) 22/62 (35%) |
|ADJUSTED (b) | 77.7% 59.6% 67.5% | 81.7% 75.5% 59.7% |
|INTERIM SACRIFICE 1 (c)| 0/4 (0%) 0/4 (0%) 0/4 (0%) | 0/4 (0%) 0/4 (0%) 0/4 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/4 (25%) 1/4 (25%) 2/4 (50%) | 0/3 (0%) 1/4 (25%) 0/4 (0%) |
|INTERIM SACRIFICE 3 (c)| 2/4 (50%) 1/4 (25%) 0/4 (0%) | 1/4 (25%) 0/4 (0%) 1/4 (25%) |
|TERMINAL (d) | 22/30 (73%) 14/28 (50%) 18/32 (56%) | 23/30 (77%) 15/23 (65%) 11/25 (44%) |
|FIRST INCIDENCE (DAYS) | 369 (I) 369 (I) 369 (I) | 426 369 (I) 473 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.507 P=0.173N P=0.520N | P=0.144N P=0.545 P=0.175N |
|INCIDENTAL TUMOR | P=0.431 P=0.099N P=0.535 | P=0.046N* P=0.237N P=0.036N* |
|LOGISTIC REGRESSION | P=0.421 P=0.087N P=0.577N | P=0.043N* P=0.179N P=0.043N* |
|COCHRAN-ARMITAGE | P=0.458 | P=0.020N* |
|FISHER EXACT | P=0.115N P=0.537N | P=0.134N P=0.019N* |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05079 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TALC
MALE TERMINAL SACRIFICE AT 106 WEEKS
FEMALE TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 185 369 549
Female interim sacrifices(days): 185 369 549
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).