TDMS Study 05079-02 Pathology Tables
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 14807966
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|
| 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|
CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + A + + + + + + + A + M + + + I + A + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + + + A A + A + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | A + M + + + + + + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + M + + + + M + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + A + + + + + + + A + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + + M + M M A A M A + + + + + + + +|
Ulcer, Focal | |
Mucosa, Atrophy | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + + + A A + A + + + + + + + +|
Hyperplasia, Lymphoid | |
Mucosa, Atrophy | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + + + + + + A + A + + + + + A + +|
Mucosa, Atrophy | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | |
Inflammation, Focal | 2 |
Necrosis, Focal | |
Serosa, Inflammation, Suppurative | 2 |
Sinusoid, Inflammation | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + A + + + + + + + +|
Acinus, Hyperplasia, Focal | 1 |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + A + + + + + + + +|
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia, Focal, Squamous | 2 |
Ulcer, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + +|
Ulcer, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration, Focal | |
Myocardium, Mineralization, Focal | |
Pericardium, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|
| 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|
CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Inflammation, Suppurative | 3 |
Corticomedullary Junction, Hemorrhage| 2 |
Spindle Cell, Hyperplasia | 3 4 4 3 2 2 3 4 3 3 2 3 2 2 3 3 2 4 4 2 3 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Vacuolization Cytoplasmic, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + M + + + + + + + + + +|
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + A M A + I + I + + I I|
__________________________________________________________________________|
Parathyroid Gland | M M M M I M + + + + + + + + M + + M + + I +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + M + + + + + + + +|
Cyst | X |
Hemorrhage, Focal | 2 2 |
Hyperplasia, Focal | 2 2 |
Pigmentation, Lipofuscin | |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + +|
Cyst | X |
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | 2 3 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Thrombosis, Chronic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + I + I + + + M + + + M + + +|
Abscess | 4 |
Cyst | X X |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 2 3 1 3 4 4 2 3 1 1 2 3 3 3 2 3 4 3|
Mucosa, Inflammation, Suppurative | |
Serosa, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + A A + A + + + + + + + +|
Hyperplasia | 3 |
Myelofibrosis | 2 1 2 3 1 2 2 2 2 2 1 3|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Inflammation | 4 |
Pancreatic, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|
| 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|
CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Inflammation | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M I + M + + M + + + + + + + I|
Infiltration Cellular, Mixed Cell | |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M M + + M + + + + + + M M + + + + +|
Depletion Lymphoid | 3 |
Hyperplasia, Histiocytic | |
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + + M + M + M M M M M M M + M M + M M|
Hyperplasia, Histiocytic | |
Infiltration Cellular, Mixed Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + M + + + + M + + M M + M + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 |
Follicular, Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 2 3 3 2 |
Inflammation, Suppurative | |
Capsule, Inflammation, Suppurative | 2 |
Lymphoid Follicle, Depletion Lymphoid| |
Lymphoid Follicle, Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + +|
Cyst | X |
Necrosis | 2 |
Cortex, Depletion Lymphoid | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + I + + A + + I + + + + +|
Edema | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Periosteum, Femur, Proliferation | |
Connective Tissue | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 1 2 2 1 2 2 1 1 1 2 2 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + I + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|
DAY ON TEST | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|
| 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|
CONTOL | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | 3 |
Metaplasia, Focal, Osseous | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 2 1 1 1 1 2 1 1 2 1 2 1 1|
Developmental Malformation | X |
Erosion, Focal | 1 1 |
Inflammation, Acute | 1 1 1 |
Ulcer, Focal | |
__________________________________________________________________________|
Trachea | + + + A + + + + + + + M + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Inflammation, Focal | 2 |
Metaplasia, Focal, Osseous | |
Nephropathy, Chronic | |
Capsule, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + +|
Submucosa, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| |
DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| |
| 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A |
CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + +| 43 |
__________________________________________________________________________|____________|
Gallbladder | + A + A + + + A A M + + + A + + A + + + A A + +| 31 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + + + + A + + + + + + A + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + A + + + + A + + + + + + A A + +| 35 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + A + + + + + + A A + +| 38 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A M M + + M + + M + + + A + + M + + + A + + +| 34 |
__________________________________________________________________________|____________|
Intestine Small | + A + A + + + + A + + + + A + + A + + + A A + +| 35 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A + + + A A + M M + A + + A + + + A A + +| 27 |
Ulcer, Focal | 4 | 1 4.0|
Mucosa, Atrophy | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + + A + + + A A + + A + + + A A + +| 33 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Mucosa, Atrophy | 2 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A M A + + + + A + + + + A + + A + + + A A + +| 33 |
Mucosa, Atrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Focal Cellular Change | X | 2 |
Hematopoietic Cell Proliferation | 3| 1 3.0|
Inflammation, Focal | | 1 2.0|
Necrosis, Focal | 1 | 1 1.0|
Serosa, Inflammation, Suppurative | 3 2 3 | 4 2.5|
Sinusoid, Inflammation | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + I + + + + A + +| 42 |
Acinus, Hyperplasia, Focal | | 1 1.0|
Serosa, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Serosa, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Hyperplasia, Focal, Squamous | 3 | 2 2.5|
Ulcer, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Ulcer, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Myocardium, Degeneration, Focal | 1| 1 1.0|
Myocardium, Mineralization, Focal | 1| 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| |
DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| |
| 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A |
CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Pericardium, Inflammation, | | |
Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Capsule, Inflammation, Suppurative | 3 2 3 | 4 2.8|
Corticomedullary Junction, Hemorrhage| 4 | 2 3.0|
Spindle Cell, Hyperplasia | 3 3 2 3 3 3 3 1 3 3 4 2 3 3 2 3 3 4 2 3 1 3 4 2| 46 2.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Cyst | X | 2 |
Vacuolization Cytoplasmic, Focal | 2 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + I + + I + + + + + + M| 41 |
Hyperplasia, Focal | 2 | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + M I I I + I + I + + + + I M M M I + + + M M +| 25 |
__________________________________________________________________________|____________|
Parathyroid Gland | M I + M M M + M + M + + I + + M M + M M M + M +| 23 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + M + + +| 42 |
Cyst | X | 2 |
Hemorrhage, Focal | | 2 2.0|
Hyperplasia, Focal | | 2 2.0|
Pigmentation, Lipofuscin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + A + + +| 43 |
Cyst | X | 2 |
C-Cell, Hyperplasia | | 1 1.0|
Follicular Cell, Hyperplasia | 1 2 2 | 9 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + | 4 |
Thrombosis, Chronic | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + M + + + + + + + M + + I + + M + + + + + + +| 38 |
Abscess | 4 4 4 | 4 4.0|
Cyst | X X X X | 6 |
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + I + + + + + + + + + + M + + +| 44 |
Thrombosis | X | 1 |
Endometrium, Hyperplasia, Cystic | 4 2 2 2 4 3 3 3 2 1 4 2 3 3 4 3 | 34 2.7|
Mucosa, Inflammation, Suppurative | 4 4 1 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| |
DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| |
| 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A |
CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Serosa, Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + A + +| 41 |
Hyperplasia | | 1 3.0|
Myelofibrosis | 2 2 2 1 1 1 3 2 2 1 3 1 2 2 2 4 | 28 1.9|
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Iliac, Inflammation | | 1 4.0|
Pancreatic, Hyperplasia, Lymphoid | 4 | 1 4.0|
Renal, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + M + + + + + + + + + + + M + + +| 38 |
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + M M + + M + + + M + + M + +| 35 |
Depletion Lymphoid | | 1 3.0|
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + M M M + + M M M M M M M M M M M M + M +| 13 |
Hyperplasia, Histiocytic | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + I + + + + M M + M +| 35 |
Infiltration Cellular, Mixed Cell | 3 2 3 2 | 5 2.4|
Follicular, Necrosis | 2 2 3 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Congestion | 3 3 | 2 3.0|
Hematopoietic Cell Proliferation | 2 4 4 3 3 3 2 | 8 3.0|
Hyperplasia, Lymphoid | 2 | 5 2.4|
Inflammation, Suppurative | 2 4 | 2 3.0|
Capsule, Inflammation, Suppurative | 1 | 2 1.5|
Lymphoid Follicle, Depletion Lymphoid| 2 3 | 2 2.5|
Lymphoid Follicle, Necrosis | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + M + + + + M + + + + + M + I +| 40 |
Cyst | X | 2 |
Necrosis | 2 1 | 3 1.7|
Cortex, Depletion Lymphoid | 3 3 2 1 | 8 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + A + + +| 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| |
DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| |
| 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A |
CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Edema | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Alopecia | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Periosteum, Femur, Proliferation | | |
Connective Tissue | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Mineralization, Focal | 1 2 2 2 1 2 2 2 1 2 2 1 2 1 1 2 1 1 2 | 36 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + M + + + + + I + + + + + + + + + + + +| 42 |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Congestion | 3 | 1 3.0|
Hyperplasia, Macrophage | 2 | 2 2.5|
Metaplasia, Focal, Osseous | 1 | 1 1.0|
Pleura, Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Cytoplasmic Alteration, Focal | 2 1 2 1 1 1 2 2 2 1 2 1 1 2 1 | 29 1.4|
Developmental Malformation | | 1 |
Erosion, Focal | 1 | 3 1.0|
Inflammation, Acute | 1 1 1| 6 1.0|
Ulcer, Focal | 1| 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + M + + + + A A + +| 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | +| 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Infarct | | 1 3.0|
Inflammation, Focal | | 1 2.0|
Metaplasia, Focal, Osseous | 2 | 1 2.0|
Nephropathy, Chronic | 1 | 1 1.0|
Capsule, Inflammation, Suppurative | 1 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7| |
DAY ON TEST | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3| |
| 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| A |
CONTOL | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + +| 44 |
Submucosa, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|
DAY ON TEST | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|
| 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|
6 MG/M3 | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + A + + + + A + + M A A A + + A A A + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + A + + + A A A + + A + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + A + + A A A A + + A A A + + + +|
Serosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + A + + A A A A + + A + A + + + +|
Serosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | A M + + + + M + A + + + M A A + + A A A M I M +|
__________________________________________________________________________|
Intestine Small | A + + A + + + + A + + A A A A + + A A A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + + + + A + + A A A A + + A A A + + + +|
Mucosa, Atrophy | 3 2 2|
Serosa, Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + A + + A A A A + + A A A A + + +|
Hyperplasia, Lymphoid | 4 |
Mucosa, Atrophy | 3 2 |
Serosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + + + A + + A A A A + + A A A + + + +|
Mucosa, Atrophy | 3 2 2|
Serosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + A + + + + + + + + + +|
Eosinophilic Focus | |
Fibrosis, Focal | |
Focal Cellular Change | X X |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Focal | 1 |
Necrosis, Focal | |
Pigmentation, Focal, Hemosiderin | |
Centrilobular, Degeneration | |
Centrilobular, Necrosis, Coagulative | 2 |
Serosa, Inflammation, Suppurative | 3 2 3 3 2 |
__________________________________________________________________________|
Pancreas | + + I + + + + + A + + + I A A + + M + A + + + +|
Serosa, Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + A + + + + + A + + + +|
Serosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + A + + + +|
Hyperplasia, Focal, Squamous | 3 2 |
Ulcer, Focal | 2 2 |
Glandular, Inflammation, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + A + + + + A + + + A + A + + + +|
Ulcer, Focal | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|
DAY ON TEST | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|
| 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|
6 MG/M3 | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Focal | 1 |
Pericardium, Inflammation, | |
Suppurative | 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + A + + + + + A + + + +|
Capsule, Inflammation, Suppurative | 2 3 2 2 3 |
Corticomedullary Junction, Hemorrhage| 2 |
Spindle Cell, Hyperplasia | 3 3 3 3 4 2 2 3 2 3 3 1 3 3 3 3 3 3 2 3 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + M A + + + + + A + + + +|
Cyst | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + A + + + + + A + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + I I I + M + A + I I M A M + M M I A + + + I|
__________________________________________________________________________|
Parathyroid Gland | + M M M M I I + M M + + + M M + M M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + I M I + + + M + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 2 3 1 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + M M + + + + M A + + + + + + + + M +|
Abscess | 4 4 4 4 4 4 |
Cyst | X X X X X X |
Thrombosis | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + A + + + + + + + + + +|
Metaplasia, Squamous | |
Endometrium, Hyperplasia, Cystic | 2 1 3 2 3 4 2 2 2 1 1 1 2 1 |
Mucosa, Inflammation, Suppurative | 1 1 2 1 |
Serosa, Inflammation, Suppurative | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + A + + + +|
Hyperplasia | 3 2 2|
Myelofibrosis | 3 1 1 4 4 3 1 1 3 1 1 1|
Myeloid Cell, Hyperplasia | 3 4 3 3 |
__________________________________________________________________________|
Lymph Node | A + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia, Lymphoid | 4 |
Renal, Inflammation | 4 |
Renal, Follicular, Necrosis | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + I M + I + + + + + M + + + + M M + + + + I +|
Hyperplasia, Histiocytic | 1 2 2 2 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|
DAY ON TEST | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|
| 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|
6 MG/M3 | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 3 3 1 2 3 2|
Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + + + M + + + + + M + M M + M + + M +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation | |
Follicular, Necrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + M M M + M M + M M + + + I M + + M M|
Hyperplasia, Histiocytic | 1 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + A + I M + A + M + A + A + M + +|
Depletion Lymphoid | |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 3 2 |
Inflammation | 4 |
Follicular, Necrosis | 3 1 2 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + A + + + +|
Hematopoietic Cell Proliferation | 3 2 2 3 3 3 |
Hyperplasia, Lymphoid | 2 3 2 2|
Capsule, Inflammation, Suppurative | 4 2 |
Lymphoid Follicle, Depletion Lymphoid| 3 |
Lymphoid Follicle, Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + I + + + + + + + M + M I + + + + + + + + +|
Cyst | |
Hyperplasia, Plasma Cell | 3 |
Inflammation, Suppurative | |
Necrosis | 2 3 |
Cortex, Depletion Lymphoid | 2 2 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + I + + + + + + I +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + M + + + + + + + + + +|
Alopecia | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Mineralization, Focal | 1 1 2 2 2 2 2 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|
DAY ON TEST | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|
| 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|
6 MG/M3 | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + A + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Hyperplasia, Macrophage | 1 1 2 2 1 1 2 2 2 2 2 1 2 2 1 1 2 2 2 1 2|
Inflammation, Chronic Active | 1 1 2 2 2 1 2 1 1 1 1|
Perivascular, Inflammation, | |
Suppurative | 1 1 |
Pleura, Inflammation, Suppurative | 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + A + + + + + + + + + + A + + + +|
Cytoplasmic Alteration, Focal | 1 2 2 3 4 1 4 4 3 2 2 2 3 2 3 2 3|
Inflammation, Acute | 1 2 |
__________________________________________________________________________|
Trachea | + + + A + + + + A + + + A M + + + A + A + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + A + + + + + + + + + +|
Casts Protein | |
Infarct | |
Inflammation, Focal | |
Nephropathy, Chronic | |
Capsule, Inflammation, Suppurative | 2 3 2 1 1 |
Renal Tubule, Hyperplasia, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + A + + + A + A + + + +|
Serosa, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| |
| 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A |
6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + A + + M A + A A + M A + + A + + + + A + A + + +| 29 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A A + + A + A A + + + + + + + + + A A + +| 35 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A A + + A + A A + + A + + + + A + A A + +| 30 |
Serosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A A + + A + A A + + + + + + + + + A A + +| 34 |
Serosa, Inflammation, Suppurative | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + A A + M A + A A + + M I + + M + + A M + M| 23 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A A + + A + A A + + A + + + + A + A A + +| 30 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + A A + + A + A A + I A + + + + A + A A M M| 26 |
Mucosa, Atrophy | 2 2 3 | 6 2.3|
Serosa, Inflammation, Suppurative | 3 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + A A + + A + A A + + A + + + + A + A A + +| 28 |
Hyperplasia, Lymphoid | | 1 4.0|
Mucosa, Atrophy | 2 2 3 3 | 6 2.5|
Serosa, Inflammation, Suppurative | 3 | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A A + + A + A A + + A + + M + A + A A + +| 29 |
Mucosa, Atrophy | 2 2 2 3 | 7 2.3|
Serosa, Inflammation, Suppurative | 3 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Eosinophilic Focus | X | 1 |
Fibrosis, Focal | 1 | 1 1.0|
Focal Cellular Change | X | 3 |
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Inflammation, Focal | 1 | 2 1.0|
Necrosis, Focal | 1 1 | 2 1.0|
Pigmentation, Focal, Hemosiderin | 3 | 1 3.0|
Centrilobular, Degeneration | 2 | 1 2.0|
Centrilobular, Necrosis, Coagulative | | 1 2.0|
Serosa, Inflammation, Suppurative | 2 4 | 7 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + A + + + + + + + + + + + + + +| 40 |
Serosa, Inflammation, Suppurative | 4 2 4 | 5 3.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 |
Serosa, Inflammation, Suppurative | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Focal, Squamous | 2 2 | 4 2.3|
Ulcer, Focal | 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| |
| 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A |
6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Glandular, Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A A + + + + + A + + + + + + + + + A + + +| 40 |
Ulcer, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myocardium, Inflammation, Focal | | 1 1.0|
Pericardium, Inflammation, | | |
Suppurative | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 46 |
Capsule, Inflammation, Suppurative | 2 2 | 7 2.3|
Corticomedullary Junction, Hemorrhage| 2 2 | 3 2.0|
Spindle Cell, Hyperplasia | 3 3 3 2 1 3 3 2 3 2 3 3 3 3 2 4 3 3 3 3 3 3 4 2| 46 2.8|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| 45 |
Cyst | X | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + I A + + + + + + + + + + + I + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Islets, Pancreatic | I + I + A M M M + I M I I + I + + + + + + M I + +| 21 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + A I I + + M I + M I M + M M + M I M + M +| 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + M + + + + + + +| 43 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 1 1 1 2 2| 12 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + A + + + + + + + + + + + + + + + + + + + +| 43 |
Abscess | 4 4 4 4 | 10 4.0|
Cyst | X X X X X | 11 |
Thrombosis | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + A + + + A + + + + + + + + + + + + + + + +| 46 |
Metaplasia, Squamous | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 1 3 2 3 4 1 1 4 1 2 1 4 2 2 2 3| 30 2.1|
Mucosa, Inflammation, Suppurative | 1 1 1 | 7 1.1|
Serosa, Inflammation, Suppurative | 1 3 | 4 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| |
| 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A |
6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + A + + + + + + + + + + + + + + + + A A + +| 44 |
Hyperplasia | 3| 4 2.5|
Myelofibrosis | 4 2 3 2 2 1 1 2 2 2 2 | 23 2.0|
Myeloid Cell, Hyperplasia | 2 4 | 6 3.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Renal, Hyperplasia, Lymphoid | 4 | 2 4.0|
Renal, Inflammation | | 1 4.0|
Renal, Follicular, Necrosis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + M + + + + I + + + + + + M + +| 37 |
Hyperplasia, Histiocytic | 1 2 1 2 1 1 2 1 2 1 2 2 1 2 1 1 2| 25 1.6|
Hyperplasia, Lymphoid | 1 3 2 1 2 3 1 2 2| 16 2.1|
Inflammation, Acute | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + + + + + + + M + + + + + + + + + + +| 38 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation | 3 | 1 3.0|
Follicular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + M + M + M + + M M M M M M + M M M M M M| 17 |
Hyperplasia, Histiocytic | 1 3 | 3 1.7|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + I A M + + + + M + + M + + + + M M + + M + +| 32 |
Depletion Lymphoid | 2 | 1 2.0|
Hyperplasia, Histiocytic | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Infiltration Cellular, Mixed Cell | 1 4 2 | 5 2.4|
Inflammation | 3 | 2 3.5|
Follicular, Necrosis | 1 2 2 1 1 1 | 12 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + A A + + + + + + + + + + + + + + + + + + +| 45 |
Hematopoietic Cell Proliferation | 3 3 2 3 4 2| 12 2.8|
Hyperplasia, Lymphoid | 2 2 2 2 | 8 2.1|
Capsule, Inflammation, Suppurative | 4 | 3 3.3|
Lymphoid Follicle, Depletion Lymphoid| 2 3 | 3 2.7|
Lymphoid Follicle, Necrosis | 2 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + M + + + I + + + + M + + + + +| 41 |
Cyst | X X| 2 |
Hyperplasia, Plasma Cell | | 1 3.0|
Inflammation, Suppurative | 4 | 1 4.0|
Necrosis | 2 2 2 | 5 2.2|
Cortex, Depletion Lymphoid | 2 2 2 2 2 | 12 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| |
| 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A |
6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Skin | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Alopecia | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydrocephalus | 3 3 | 2 3.0|
Mineralization, Focal | 2 1 1 1 2 2 2 2 2 2 1 2 1 2 2 2 1 2 2| 33 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + A + + + + + + + + + I + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 | 3 2.7|
Hyperplasia, Macrophage | 2 3 2 1 1 2 2 1 2 2 2 1 1 1 2 1 2 2 1 1 1 1 2 2| 45 1.6|
Inflammation, Chronic Active | 2 2 1 1 2 1 1 1 1 1 2 2 1 1| 25 1.4|
Perivascular, Inflammation, | | |
Suppurative | 3 | 3 1.7|
Pleura, Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cytoplasmic Alteration, Focal | 4 2 3 2 1 4 2 1 4 2 3 1 2 3 2 3 2 3 2 2| 37 2.5|
Inflammation, Acute | 2 1 | 4 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + A + + + + + M + + + + + + + + + + A M M M| 37 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Casts Protein | 2 2| 2 2.0|
Infarct | 1 | 1 1.0|
Inflammation, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7| |
DAY ON TEST | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3| |
| 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8| A |
6 MG/M3 | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 2| 1 2.0|
Capsule, Inflammation, Suppurative | 2 | 6 1.8|
Renal Tubule, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A A + + A + + + + + + + + + + + + A + + +| 41 |
Serosa, Inflammation, Suppurative | 1 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|
| 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|
18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M M M A A A M + A A + A + A + A + M + M + + A + +|
__________________________________________________________________________|
Intestine Large | A A A + + A A + A A + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A A + A A A + A A + + + + + + + + + + + + A + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | A A A + A A A + A A + A + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | A A M + + A A + A M + + + + + M M + + + M + A + +|
__________________________________________________________________________|
Intestine Small | A A A + A A A + A A + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A A + A A A M A A + A M A + M + + + + M + A + +|
Mucosa, Atrophy | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | A A A A A A A + A A + + + A + + + + + + + + A + +|
Mucosa, Atrophy | 2 |
Peyer's Patch, Necrosis | 2 |
Serosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | A A A + A A A + A A + A + A + A + + + + + + A + +|
Mucosa, Atrophy | |
Serosa, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Focal | |
Necrosis, Focal | |
Serosa, Inflammation, Suppurative | 3 3 3 |
__________________________________________________________________________|
Pancreas | + + A + M A + + + + + + + + + + + + + + + + A + +|
Inflammation, Focal | 1 |
Serosa, Inflammation, Suppurative | 3 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Granulomatous | 1 |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Mast Cell | |
Hyperplasia, Focal, Squamous | 3 |
Glandular, Inflammation, Focal | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + A + + + + + A + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pericardium, Inflammation, | |
Suppurative | 1 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|
| 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|
18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Inflammation, Suppurative | 2 3 1 |
Corticomedullary Junction, Hemorrhage| |
Spindle Cell, Hyperplasia | 1 2 1 1 1 3 3 3 3 3 2 3 3 2 2 3 2 3 2 3 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal, Suppurative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | I I + M + + I + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + M I M A M + + M I + M I I M + I + I + I A I I|
__________________________________________________________________________|
Parathyroid Gland | M M M + + M M M I + I + + M + + + + + I M M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + M I + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 2 |
C-Cell, Hyperplasia | 1|
Follicular Cell, Hyperplasia | 1 3 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + + + + + + + +|
Abscess | 4 4 4 4 |
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + M + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Focal, Histiocytic | 2 |
Endometrium, Hyperplasia, Cystic | 1 1 1 4 2 3 1 3 1 2 1 2 1 1 2 3|
Mucosa, Inflammation, Suppurative | 1 2 1 |
Serosa, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + + + + + + A + + + + + + + A +|
Hyperplasia | 2 3 |
Myelofibrosis | 1 3 1 2 1 2 1 1 3 3 2 3 2|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Iliac, Inflammation | |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Pancreatic, Infiltration Cellular, | |
Mixed Cell | |
Pancreatic, Follicular, Necrosis | 2 |
Renal, Hyperplasia, Lymphoid | 4 |
Renal, Infiltration Cellular, Mixed | |
Cell | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|
| 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|
18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Inflammation | |
Renal, Follicular, Necrosis | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | M M I + M M M + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 3 3 3 4 3 3 4 1 2 2 2 3 2 3 3 3 4|
Hyperplasia, Lymphoid | 2 2 3 2 2 3|
Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M + + + M + + + + + + M + I + + M + + + + +|
Cyst | |
Hyperplasia, Lymphoid | |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M M M + + M M M M M + M M + M M + + M M|
Hyperplasia, Histiocytic | 2 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M A A + M M M M + + + + + M + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematocyst | X|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation | |
Follicular, Necrosis | 3 1 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 4 3 3 4 |
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Suppurative | |
Capsule, Inflammation, Suppurative | 2 |
Lymphoid Follicle, Depletion Lymphoid| 2 3 3 3 2 |
Lymphoid Follicle, Necrosis | 2 |
__________________________________________________________________________|
Thymus | M + + M + + M + + + + + + M + + + + I + + + M + +|
Inflammation, Suppurative | 3 |
Cortex, Depletion Lymphoid | 3 1 3 3 3 3 2 3 1 1 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 1 1 1 2 2 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|
| 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|
18 MG/M3 | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Macrophage | 2 3 3 3 3 3 3 3 3 2 3 3 3 3 3 2 2 2 3|
Inflammation, Chronic Active | 1 2 2 2 2 2 2 2 3 3 3 3 3 3 1 1 3|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Perivascular, Inflammation, | |
Suppurative | 3 |
Pleura, Inflammation, Suppurative | 1 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 1 4 3 4 2 4 4 4 4 3 4 4 4 4 3 2 3|
Erosion, Focal | 1 |
Inflammation, Acute | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
Metaplasia, Focal, Osseous | 1 |
Capsule, Inflammation, Suppurative | 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + A + + + + + + A + + + + + + + + A + +|
Serosa, Inflammation, Suppurative | 4 2 |
Submucosa, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| |
| 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A |
18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + A + + + + + A + + M + A + + + + A| 29 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + A + + A + + + + + A + + + A + + + + + A| 36 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + A + + A + + + + + A + + + A A + + + + A| 34 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + A + + A + + + + + A + + I A A + + + + A| 32 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + M M + A + M + M + A + I M M + I + + + A| 27 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + A + + A + + + + + A + + + A + + + + + A| 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M A + A + + A + + + + + A + + + A A + + + + A| 27 |
Mucosa, Atrophy | 2 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + A + + + + + A + A + A A + + + + A| 31 |
Mucosa, Atrophy | 2 2 3 2 3 | 6 2.3|
Peyer's Patch, Necrosis | | 1 2.0|
Serosa, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + A + + + + + A + A + A + + + + + A| 31 |
Mucosa, Atrophy | 3 2 3 | 3 2.7|
Serosa, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | X | 1 |
Hematopoietic Cell Proliferation | 4 | 2 3.0|
Inflammation, Focal | 3 | 1 3.0|
Necrosis, Focal | 1 1 | 2 1.0|
Serosa, Inflammation, Suppurative | 2 1| 5 2.4|
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + A| 44 |
Inflammation, Focal | 3 | 2 2.0|
Serosa, Inflammation, Suppurative | 3 | 4 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Serosa, Inflammation, Granulomatous | | 1 1.0|
Serosa, Inflammation, Suppurative | 1| 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Mast Cell | 2 | 1 2.0|
Hyperplasia, Focal, Squamous | 2 | 2 2.5|
Glandular, Inflammation, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + I| 46 |
Inflammation, Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| |
| 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A |
18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pericardium, Inflammation, | | |
Suppurative | 1| 4 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Inflammation, Suppurative | 3 2| 5 2.2|
Corticomedullary Junction, Hemorrhage| 2| 1 2.0|
Spindle Cell, Hyperplasia | 4 3 2 3 3 2 2 3 3 2 2 3 3 3 3 3 3 2 3 3 3 3 3 3| 47 2.6|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + M + I + M I + M + + + + + I I + I I| 23 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + I + + + M M M + M + M M + + M I M + +| 25 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute, Focal | | 2 1.5|
C-Cell, Hyperplasia | | 1 1.0|
Follicular Cell, Hyperplasia | 2 2 1 1 1 1 | 10 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + I M + + M + + + + + +| 46 |
Abscess | 4 4 4| 7 4.0|
Cyst | X X X X X | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
Hyperplasia, Focal, Histiocytic | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 3 2 2 1 2 2 1 3 3 2 3 2 1 1 2 3 2 2 | 35 1.9|
Mucosa, Inflammation, Suppurative | 1 | 4 1.3|
Serosa, Inflammation, Suppurative | 2| 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + A| 45 |
Hyperplasia | 3 3 2 | 5 2.6|
Myelofibrosis | 2 1 2 2 1 2 3 2 1 1 3 1 1 2 | 27 1.8|
Myeloid Cell, Hyperplasia | 4 3 3 | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| |
| 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A |
18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Iliac, Hyperplasia, Lymphoid | 2 | 1 2.0|
Iliac, Inflammation | 3 | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Pancreatic, Infiltration Cellular, | | |
Mixed Cell | 2 | 1 2.0|
Pancreatic, Follicular, Necrosis | | 1 2.0|
Renal, Hyperplasia, Lymphoid | 3 | 2 3.5|
Renal, Infiltration Cellular, Mixed | | |
Cell | 2 | 1 2.0|
Renal, Inflammation | 3 | 1 3.0|
Renal, Follicular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + + + + + + +| 43 |
Hyperplasia, Histiocytic | 3 2 3 3 3 4 2 2 3 3 3 2 2 3 1 2 1 3 3 2 2 2| 39 2.6|
Hyperplasia, Lymphoid | 4 3 3 1 3 3 2 2 3 2 3 3 2 4 | 20 2.6|
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M + + + + + + + + + M M M + + + + + M + + + + M| 36 |
Cyst | X | 1 |
Hyperplasia, Lymphoid | 2 4 3 | 3 3.0|
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M M M + + M M + M M M M M M M + M M M + M M| 14 |
Hyperplasia, Histiocytic | | 2 3.0|
Hyperplasia, Lymphoid | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + M + + A + + + + + M + + + + + + + + M +| 37 |
Depletion Lymphoid | 2 | 2 2.0|
Hematocyst | | 1 |
Hyperplasia, Histiocytic | 1 | 1 1.0|
Hyperplasia, Lymphoid | 2 | 2 2.5|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | 2 3 3 1 | 5 2.4|
Inflammation | 4 | 1 4.0|
Follicular, Necrosis | 3 2 2 | 7 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 4 2| 10 3.2|
Hyperplasia, Lymphoid | 3 2 3 2 | 6 2.3|
Inflammation, Suppurative | 3 | 1 3.0|
Capsule, Inflammation, Suppurative | 4 2| 3 2.7|
Lymphoid Follicle, Depletion Lymphoid| | 5 2.6|
Lymphoid Follicle, Necrosis | 1| 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| |
| 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A |
18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + M + + + + + I +| 41 |
Inflammation, Suppurative | | 1 3.0|
Cortex, Depletion Lymphoid | 4 2 2 3| 15 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + I + + + + + + + + + + + + + + + +| 48 |
Abscess | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization, Focal | 1 1 2 2 1 2 1 2 2 2 2 2 2 1 1 2 2 2 2 | 29 1.6|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Macrophage | 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 2 4 3 3 3 2 3 3| 43 2.8|
Inflammation, Chronic Active | 3 2 2 3 3 3 2 2 2 2 3 2 3 3 2 2 1 2 3 3 2| 38 2.3|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
Perivascular, Inflammation, | | |
Suppurative | | 1 3.0|
Pleura, Inflammation, Suppurative | 2 1| 5 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration, Focal | 4 4 4 4 3 4 4 4 3 3 3 3 3 3 4 2 2 1 3 4 4 4 2| 40 3.3|
Erosion, Focal | | 1 1.0|
Inflammation, Acute | 1 2 1 | 5 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + M + I + A + + + M + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6| |
| 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6| A |
18 MG/M3 | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Focal | 2 | 1 2.0|
Metaplasia, Focal, Osseous | 1 | 2 1.0|
Capsule, Inflammation, Suppurative | 1 1| 5 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + A + + A + + + + + A + + + A + + + + + +| 41 |
Serosa, Inflammation, Suppurative | 2 | 3 2.7|
Submucosa, Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 1| 5| 1| 7| 1| 5| 5| 4| 7| 5| 5| 0| 1| 7| 7| 7| 7| 3| 5| 7| 5|
DAY ON TEST | 3| 3| 4| 6| 8| 4| 8| 1| 8| 4| 4| 0| 1| 4| 3| 2| 8| 3| 0| 3| 3| 6| 0| 3| 5|
| 2| 2| 9| 9| 5| 9| 5| 1| 6| 9| 9| 4| 5| 9| 2| 8| 6| 2| 1| 2| 2| 8| 4| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7|
CONTROL | 8| 9| 0| 3| 5| 7| 8| 6| 7| 8| 0| 2| 3| 4| 9| 6| 7| 8| 9| 7| 8| 9| 6| 8| 2|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + I + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + |
Clear Cell Focus | |
Inflammation, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
Inflammation, Chronic | |
Duct, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
Spindle Cell, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + M + M M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + M + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + |
Endometrium, Hyperplasia, Cystic | 2 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 1| 5| 1| 7| 1| 5| 5| 4| 7| 5| 5| 0| 1| 7| 7| 7| 7| 3| 5| 7| 5|
DAY ON TEST | 3| 3| 4| 6| 8| 4| 8| 1| 8| 4| 4| 0| 1| 4| 3| 2| 8| 3| 0| 3| 3| 6| 0| 3| 5|
| 2| 2| 9| 9| 5| 9| 5| 1| 6| 9| 9| 4| 5| 9| 2| 8| 6| 2| 1| 2| 2| 8| 4| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7|
CONTROL | 8| 9| 0| 3| 5| 7| 8| 6| 7| 8| 0| 2| 3| 4| 9| 6| 7| 8| 9| 7| 8| 9| 6| 8| 2|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + M |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + |
Cortex, Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + |
__________________________________________________________________________|
Skin | + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Mineralization, Focal | 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + |
__________________________________________________________________________|
Nose | + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Inflammation, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 1| 7| 3| 1| 3| 5| 1| 3| 1| 5| 3| 6| 5| 3| | |
DAY ON TEST | 8| 3| 6| 8| 6| 4| 8| 6| 8| 5| 6| 9| 7| 6| | |
| 6| 2| 8| 6| 9| 9| 7| 9| 7| 0| 9| 4| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 7| 7| 9| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 4| | A |
CONTROL | 6| 7| 8| 9| 3| 6| 8| 0| 6| 2| 5| 6| 7| 0| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 11 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + | 11 |
Clear Cell Focus | X | 1 |
Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + | 11 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 11 |
Inflammation, Chronic | 1 | 1 1.0|
Duct, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + M + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + | 11 |
Spindle Cell, Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 1| 7| 3| 1| 3| 5| 1| 3| 1| 5| 3| 6| 5| 3| | |
DAY ON TEST | 8| 3| 6| 8| 6| 4| 8| 6| 8| 5| 6| 9| 7| 6| | |
| 6| 2| 8| 6| 9| 9| 7| 9| 7| 0| 9| 4| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 7| 7| 9| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 4| | A |
CONTROL | 6| 7| 8| 9| 3| 6| 8| 0| 6| 2| 5| 6| 7| 0| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + | 11 |
Endometrium, Hyperplasia, Cystic | 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 11 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 11 |
Cortex, Depletion Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 11 |
Mineralization, Focal | 1 2 | 5 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 11 |
__________________________________________________________________________|____________|
Lung | + + + + + | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + | 11 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 11 |
Inflammation, Focal | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 3| 5| 5| 3| 3| 7| 1| 7| 6| 3| 1| 1| 6| 5| 7| 7| 1| 5| 0| 6| 7| 1| 3| 0| 5|
DAY ON TEST | 6| 4| 4| 6| 6| 1| 8| 3| 5| 6| 8| 8| 5| 4| 3| 3| 8| 4| 1| 7| 3| 8| 6| 0| 2|
| 9| 9| 9| 8| 9| 7| 5| 2| 9| 8| 5| 6| 5| 9| 2| 2| 6| 9| 7| 8| 2| 7| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 4| 4| 4| 5| 5| 5| 7| 7| 8| 8| 8| 8| 8| 1| 1| 1| 1|
6 MG/M3 | 7| 8| 1| 3| 5| 6| 7| 8| 6| 8| 9| 1| 7| 9| 7| 9| 0| 2| 4| 6| 8| 0| 2| 3| 4|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + M + + + + + |
__________________________________________________________________________|
Gallbladder | + + + M + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M |
__________________________________________________________________________|
Intestine Small | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + |
Inflammation, Focal | 1 |
__________________________________________________________________________|
Pancreas | + + + + + M + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
Inflammation, Chronic | 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
Hyperplasia, Focal, Squamous | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + |
Spindle Cell, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + + |
__________________________________________________________________________|
Parathyroid Gland | M + + M M M M M |
__________________________________________________________________________|
Pituitary Gland | + + + M M + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + M + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + M + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + |
Endometrium, Hyperplasia, Cystic | 1 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
Myelofibrosis | 1 1 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 3| 5| 5| 3| 3| 7| 1| 7| 6| 3| 1| 1| 6| 5| 7| 7| 1| 5| 0| 6| 7| 1| 3| 0| 5|
DAY ON TEST | 6| 4| 4| 6| 6| 1| 8| 3| 5| 6| 8| 8| 5| 4| 3| 3| 8| 4| 1| 7| 3| 8| 6| 0| 2|
| 9| 9| 9| 8| 9| 7| 5| 2| 9| 8| 5| 6| 5| 9| 2| 2| 6| 9| 7| 8| 2| 7| 9| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 4| 4| 4| 5| 5| 5| 7| 7| 8| 8| 8| 8| 8| 1| 1| 1| 1|
6 MG/M3 | 7| 8| 1| 3| 5| 6| 7| 8| 6| 8| 9| 1| 7| 9| 7| 9| 0| 2| 4| 6| 8| 0| 2| 3| 4|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + + + M |
Hyperplasia, Histiocytic | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + M + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Mineralization, Focal | 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + |
Hyperplasia, Macrophage | 1 2 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + |
Cytoplasmic Alteration, Focal | 2 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + |
Inflammation, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1| | |
DAY ON TEST | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8| | |
| 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| | A |
6 MG/M3 | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 11 |
__________________________________________________________________________|____________|
Gallbladder | + + + M | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + | 12 |
Inflammation, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 11 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 12 |
Hyperplasia, Focal, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | M + + + | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 12 |
Spindle Cell, Hyperplasia | 2 | 4 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | I + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | M M + + | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | M M + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + | 11 |
__________________________________________________________________________|____________|
Uterus | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1| | |
DAY ON TEST | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8| | |
| 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| | A |
6 MG/M3 | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 12 |
Myelofibrosis | | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + M | 6 |
Hyperplasia, Histiocytic | 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + | 11 |
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + | 11 |
Hyperplasia, Histiocytic | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 12 |
__________________________________________________________________________|____________|
Thymus | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 12 |
__________________________________________________________________________|____________|
Skin | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 12 |
Mineralization, Focal | 1 | 6 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 12 |
__________________________________________________________________________|____________|
Lung | + + + + | 12 |
Hyperplasia, Macrophage | 1 1 | 8 1.1|
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
Cytoplasmic Alteration, Focal | 1 | 5 1.2|
__________________________________________________________________________|____________|
Trachea | M + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1| | |
DAY ON TEST | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8| | |
| 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7| | A |
6 MG/M3 | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 12 |
Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 0| 0| 1| 7| 0| 0| 4| 3| 1| 7| 3| 5| 3| 7| 5| 1| 2| 3| 5| 1| 5| 1| 5| 7| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 9| 6| 8| 3| 6| 4| 6| 3| 0| 8| 8| 6| 4| 8| 4| 8| 4| 3| 3|
| 8| 8| 4| 2| 8| 8| 5| 9| 6| 2| 8| 6| 9| 2| 8| 5| 6| 8| 9| 7| 9| 5| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 5| 5| 6| 6| 6| 6| 6| 6| 8| 9| 9| 9|
18 MG/M3 | 7| 8| 9| 0| 5| 8| 9| 6| 0| 1| 3| 5| 7| 7| 8| 2| 3| 4| 5| 8| 9| 7| 1| 3| 5|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + |
__________________________________________________________________________|
Gallbladder | M M + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + |
__________________________________________________________________________|
Liver | + + + + |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Pancreas | + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + |
Spindle Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + I + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + |
__________________________________________________________________________|
Thyroid Gland | M + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + |
__________________________________________________________________________|
Uterus | + + + + |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 4 |
Mucosa, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
Myelofibrosis | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 0| 0| 1| 7| 0| 0| 4| 3| 1| 7| 3| 5| 3| 7| 5| 1| 2| 3| 5| 1| 5| 1| 5| 7| 7|
DAY ON TEST | 2| 2| 1| 2| 2| 2| 9| 6| 8| 3| 6| 4| 6| 3| 0| 8| 8| 6| 4| 8| 4| 8| 4| 3| 3|
| 8| 8| 4| 2| 8| 8| 5| 9| 6| 2| 8| 6| 9| 2| 8| 5| 6| 8| 9| 7| 9| 5| 9| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 5| 5| 6| 6| 6| 6| 6| 6| 8| 9| 9| 9|
18 MG/M3 | 7| 8| 9| 0| 5| 8| 9| 6| 0| 1| 3| 5| 7| 7| 8| 2| 3| 4| 5| 8| 9| 7| 1| 3| 5|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + |
Hyperplasia, Histiocytic | 1 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | I M M M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Spleen | + + + + |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + |
__________________________________________________________________________|
Skin | + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Mineralization, Focal | 1 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + |
__________________________________________________________________________|
Lung | + + + + |
Hyperplasia, Macrophage | 2 2 1 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + |
Cytoplasmic Alteration, Focal | 2 2 2 |
Cytoplasmic Alteration | 2 |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3| | |
DAY ON TEST | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6| | |
| 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5| | A |
18 MG/M3 | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M | 10 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 12 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 12 |
Spindle Cell, Hyperplasia | 3 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M + + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 12 |
Endometrium, Cyst | X | 1 |
Endometrium, Hyperplasia, Cystic | 2 3 3 2 | 5 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3| | |
DAY ON TEST | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6| | |
| 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5| | A |
18 MG/M3 | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + | 11 |
Myelofibrosis | 2 | 1 2.0|
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | I + + + + + + + | 11 |
Hyperplasia, Histiocytic | 2 4 3 3 3 | 8 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + | 11 |
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M M | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + | 10 |
Hyperplasia, Histiocytic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 12 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 12 |
Mineralization, Focal | 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 12 |
Hyperplasia, Macrophage | 1 2 1 1 3 3 2 2 | 12 1.8|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 12 |
Cytoplasmic Alteration, Focal | 2 2 2 2 2 | 8 2.0|
Cytoplasmic Alteration | 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3| | |
DAY ON TEST | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6| | |
| 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5| | A |
18 MG/M3 | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|
| 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|
CONTROL | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + M + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | M + M + + A A + M + + + + + M A + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + A A + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A A + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A A + + + + + + + + A + + + + + + + A|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A A + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + A A + + + + + + + + A + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A A + A + + + + + + A + + + + + + + A|
Mucosa, Atrophy | 4 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A A + + + + + + + + A + + + + + + + A|
Hyperplasia, Lymphoid | 2 2 2 |
Mucosa, Atrophy | 2 4 |
Peyer's Patch, Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A A + + + + + + + + A + + M + + + + A|
Mucosa, Atrophy | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + A|
Abscess | |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | 4 |
Infarct | 4 3 |
Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + A + + + + + + + M|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + I + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Glandular | + + + + + M A + + + + + + + + A + + + + + + + A|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + A|
Myocardium, Degeneration, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | I + + + + + M + + + + + + + + + + + + + + + + A|
Spindle Cell, Hyperplasia | 1 1 2 1 1 1 3 1 2 1 1 1 1 1 4 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | I + + + + + M + + + + + + + + + + + + + + + + A|
Atrophy | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + M M M + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + M + M + + I M + + + A + M I + + I + M|
__________________________________________________________________________|
Parathyroid Gland | + M M M + M M M M + M + + M + + + + M M M + + M|
Cyst | X X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + M|
Cyst | X |
Pigmentation, Lipofuscin | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|
| 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|
CONTROL | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A|
Cyst | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + M + + M + + I + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Preputial Gland | + |
Dilatation | 3 |
Inflammation | |
__________________________________________________________________________|
Prostate | + + + + + I + + + + + + + + + + + + + + + + + M|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + A + + + + + + + A|
Hypospermia | |
Seminiferous Tubule, Degeneration, | |
Focal | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + A + + + + + A + + + A + + + + + + + A|
Hyperplasia | 2 |
Myelofibrosis | 1 |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + M|
Iliac, Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia, Plasma Cell | 3 |
Lumbar, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M I + + + M + + + + + + M M + M|
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 2 4 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Acute | |
Follicular, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M M + M + + M M M M + M M M + + + + M + + M|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M I + M M + + M M M M + M M M M M M M|
Hyperplasia, Histiocytic | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + I M + M + + + + + + + M + + + + + + + M|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mixed Cell | 3 3 2 2 2 1 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|
| 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|
CONTROL | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | |
Lymphoid Follicle, Necrosis | 2 |
__________________________________________________________________________|
Thymus | M + + + + M + + I I + M + + + A + + + + + + + M|
Cyst | X X |
Necrosis | 3 |
Cortex, Depletion Lymphoid | 2 2 |
Epithelial Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M + + M M M + M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Rib, Cartilage, Fracture Healed | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 2 2 1 2 2 1 2 2 1 2 2 2 3 2 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + I + + + + + I + + + + + A + + + + + + + A|
Inflammation, Acute | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + A|
Congestion | 2 |
Hyperplasia, Macrophage | 4 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Perivascular, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + A + + + + + + + +|
Cytoplasmic Alteration, Focal | 1 1 1 1 |
Erosion, Focal | 1 |
Inflammation, Acute | 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + M + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|
| 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|
CONTROL | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A|
Casts Protein | 3 |
Cyst | X |
Hydronephrosis | 2 3 2 |
Inflammation, Focal, Suppurative | |
Nephropathy, Chronic | 4 |
Pelvis, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + A|
Dysplasia, Focal | 3 |
Inflammation, Chronic Active | 3 3 1 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | |
| 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + M + + + M + + + | 41 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + + A M + M A A + + A | 31 |
__________________________________________________________________________|____________|
Intestine Large | + + A + + + + + + + + + + A A + A A A + + + | 36 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + A + + A A + A A A + + A | 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + A A + A A A + + + | 36 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | I + A + + + + + + + A + M A A + A A A + + M | 32 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + A + + A A + A A A + + A | 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + M + A + + A A + A A A + + A | 32 |
Mucosa, Atrophy | 3 | 3 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + A + A A A + A A A + + A | 33 |
Hyperplasia, Lymphoid | 2 2 | 5 2.0|
Mucosa, Atrophy | 3 | 3 3.0|
Peyer's Patch, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + A + A A A + A A A + + A | 32 |
Mucosa, Atrophy | 3 3 | 3 3.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Abscess | 4 | 1 4.0|
Focal Cellular Change | X X X | 4 |
Hematopoietic Cell Proliferation | 2 | 2 3.0|
Infarct | | 2 3.5|
Necrosis, Focal | 1 4 1 | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + | 42 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + M | 43 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + + + + + + + + + + + + A + I + | 39 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Myocardium, Degeneration, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + | 43 |
Spindle Cell, Hyperplasia | 1 1 2 3 3 2 1 2 2 2 2 1 2 1 2 1 2 3 3 2 2 | 38 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + | 43 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + I | 39 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + I M + M I + I I + M I + + + + I A M + + | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | |
| 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M + + + + + + M M M + M + + + + M + | 25 |
Cyst | X | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + | 44 |
Cyst | | 1 |
Pigmentation, Lipofuscin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Cyst | X X | 2 |
Follicular Cell, Hyperplasia | 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + M + + M + + + + M + + M + + + + + + + | 39 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 8 |
Dilatation | 3 4 4 3 4 2 | 7 3.3|
Inflammation | 4 2 4 | 3 3.3|
__________________________________________________________________________|____________|
Prostate | M + M I + + + + + + + + + + M + + + + + + + | 40 |
Inflammation, Suppurative | 3 2 1 | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + A + + A A + + A | 41 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + M + + + + + + + | 43 |
Hypospermia | X | 1 |
Seminiferous Tubule, Degeneration, | | |
Focal | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + + + + + + + + + + + + + + A + + + | 40 |
Hyperplasia | 3 2 3 | 4 2.5|
Myelofibrosis | 1 | 2 1.0|
Myeloid Cell, Hyperplasia | 3 2 4 | 4 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Lumbar, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + M + + + M I M + + I M M I | 32 |
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 3 3.0|
Infiltration Cellular, Mixed Cell | 3 1 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | |
| 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Acute | 4 | 1 4.0|
Follicular, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M M + + M + + + M + + + M M M M M + + M | 23 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M M M M M M + M M M + M M M M M + M M | 9 |
Hyperplasia, Histiocytic | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + + + + I + M + + + M + + + A + + + | 36 |
Depletion Lymphoid | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 3 2 2 | 4 2.3|
Infiltration Cellular, Mixed Cell | 2 3 2 3 4 3 3 3 1 3 3 | 18 2.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + | 44 |
Hematopoietic Cell Proliferation | 3 3 2 2 2 | 6 2.5|
Hyperplasia, Lymphoid | 2 3 2 | 3 2.3|
Lymphoid Follicle, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | I + M + + + + + + + + + I M M + + + + + + + | 34 |
Cyst | X | 3 |
Necrosis | | 1 3.0|
Cortex, Depletion Lymphoid | 2 2 3 2 | 6 2.2|
Epithelial Cell, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M I M M M M M M M M M M I M M M | 5 |
__________________________________________________________________________|____________|
Skin | + I + + + + + + + + + + M + + + + + + + + + | 44 |
Alopecia | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + | 46 |
Rib, Cartilage, Fracture Healed | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + | 46 |
Mineralization, Focal | 1 2 2 2 2 2 2 2 1 1 2 2 2 2 1 2 2 2 2 | 37 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + | 42 |
Inflammation, Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Congestion | 3 4 | 3 3.0|
Hyperplasia, Macrophage | 1 | 3 2.3|
Alveolar Epithelium, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9| | |
| 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
CONTROL | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Focal | 1 | 1 1.0|
Perivascular, Inflammation, | | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Cytoplasmic Alteration, Focal | 1 | 5 1.0|
Erosion, Focal | | 1 1.0|
Inflammation, Acute | 1 | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + A + + + + + + + + + + + + + + A + + + + | 42 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + | 45 |
Casts Protein | | 1 3.0|
Cyst | X | 2 |
Hydronephrosis | | 3 2.3|
Inflammation, Focal, Suppurative | 4 4 4 | 3 4.0|
Nephropathy, Chronic | 3 4 | 3 3.7|
Pelvis, Inflammation, Suppurative | 4 | 2 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + | 43 |
Dysplasia, Focal | | 1 3.0|
Inflammation, Chronic Active | 3 3 2 | 6 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|
| 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|
6 MG/M3 | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + M + + + A + + A + A A + I + + + I + + I |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + A + A A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + A + + A + A A + + + + + + + + A |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + A + A A + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + A I A M + + + + + + M + A |
Serosa, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Intestine Small | + + + A + + + A + + A + A A + + + + + + + + A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A M + + A + M A + A A + + + + + + + + A |
Mucosa, Atrophy | 2 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + A + A A + A + + + + + + A |
Hyperplasia, Lymphoid | |
Mucosa, Atrophy | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + A + + A + A A + + + + M + + + A |
Mucosa, Atrophy | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + |
Focal Cellular Change | X X X |
Hematocyst | X |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Focal | 1 |
Mineralization, Focal | 1 |
Necrosis, Focal | 2 1 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + M + M M + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + A A + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + A A + + + + + + + + I |
Hyperplasia, Focal, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + A A + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + M + + + + + + + + + + + + + + |
Thrombosis | |
Coronary Artery, Mineralization | |
Myocardium, Fibrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + A + + + + + + + + + + + + |
Spindle Cell, Hyperplasia | 2 1 2 2 3 2 2 2 2 1 1 1 2 2 3 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + A + + + + + + + + + + + + |
Hyperplasia, Focal | |
Vacuolization Cytoplasmic, Focal | 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|
| 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|
6 MG/M3 | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | M M + + + + + + + + A + + + + + + + + + + + I |
__________________________________________________________________________|
Islets, Pancreatic | + M + A M I M + M + M I M M + M M + I + I + + |
__________________________________________________________________________|
Parathyroid Gland | M + M + M M M + + M M + M M + M + + I M I M + |
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Follicular Cell, Hyperplasia | 2 2 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + M + + I + A + + + + + + + + + M + + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Preputial Gland | + + |
Dilatation | 3 2 |
__________________________________________________________________________|
Prostate | + + + A + + + + + + + + + + + M + + + + + + + |
Inflammation, Suppurative | 4 3 3 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + A + + + + + + A + + + + + + + + + + + + |
Inflammation, Suppurative | 4 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + A + + + + + + + + + + + + |
Hypospermia | |
Inflammation, Suppurative | 4 |
Seminiferous Tubule, Degeneration, | |
Focal | 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 |
Myelofibrosis | 1 1 |
Myeloid Cell, Hyperplasia | 3 2 4 2 |
__________________________________________________________________________|
Lymph Node | + + M + + + + + + + + + + + + + + + + + + + + |
Lumbar, Hyperplasia, Lymphoid | 3 |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Pancreatic, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + I + + M M + + + + + |
Hyperplasia, Histiocytic, Lymphoid | |
Hyperplasia, Histiocytic | 1 2 2 2 2 1 1 1 2 3 2 2 2 2 2 4 1 |
Hyperplasia, Lymphoid | 2 1 1 1 |
Infiltration Cellular, Mixed Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M M M + M + + + M + M + + + M M + M M M M |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|
| 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|
6 MG/M3 | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Histiocytic | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M M M M + M M + M M M M M M M + M M M |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M M + + + M + + M + M + + M + + + + + + + |
Hyperplasia, Lymphoid | 2 3 |
Infiltration Cellular, Mixed Cell | 3 2 2 2 3 3 |
Inflammation, Granulomatous | |
Follicular, Necrosis | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + A + + + + + + + + + |
Hematocyst | |
Hematopoietic Cell Proliferation | 2 2 2 |
Hyperplasia, Lymphoid | 3 2 |
Inflammation, Granulomatous | |
Lymphoid Follicle, Depletion Lymphoid| |
Lymphoid Follicle, Necrosis | 3 3 3 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + A + M + M M M I + + + M + |
Cyst | X |
Inflammation, Granulomatous | |
Cortex, Depletion Lymphoid | 1 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M M M M M M + M M M M M M M + M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + I + M + + + + + + + + + + + + + + |
Abscess | |
Inflammation, Acute | 4 |
Ulcer, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + |
Mineralization, Focal | 2 2 2 2 2 1 2 1 2 2 2 1 2 1 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + I + A + + + + + + A + A A + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 |
Hyperplasia, Macrophage | 1 1 2 2 2 1 1 1 1 2 1 2 1 1 1 2 1 1 1 2 2 1 |
Inflammation, Chronic Active | 1 1 3 1 1 1 1 1 1 1 |
Peribronchiolar, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|
| 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|
6 MG/M3 | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Cytoplasmic Alteration, Focal | 2 2 1 3 3 2 1 1 1 1 3 1 2 2 3 |
Erosion, Focal | |
Inflammation, Acute | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + A I + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + |
Hydronephrosis | 4 |
Inflammation, Focal, Suppurative | 4 4 |
Metaplasia, Focal, Osseous | |
Pelvis, Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + A + + A + A A + + + + + + + + + |
Inflammation, Chronic Active | 3 3 |
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5| | |
DAY ON TEST | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5| | |
| 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| | A |
6 MG/M3 | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + M A + + + A M M + A A + + A + + A | 29 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + A + + + A + + + A + + + + + + A | 38 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + A + + + A + A + A + + + + + + A | 35 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + A + + + A + + + A + + + + + + A | 38 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + A + + A + + + A + + + A M + + + + M A | 32 |
Serosa, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + A + + + A A A + A + + + + + + A | 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + A + + + A A A + A + + A A + + A | 30 |
Mucosa, Atrophy | 2 2 2 2 2 | 7 2.1|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + A + + + A A A + A + + + A + + A | 32 |
Hyperplasia, Lymphoid | 4 2 4 | 3 3.3|
Mucosa, Atrophy | 2 2 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + A + + + A A A + A A + + + M + A | 31 |
Mucosa, Atrophy | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Focal Cellular Change | | 3 |
Hematocyst | | 1 |
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Inflammation, Focal | 1 1 | 3 1.0|
Mineralization, Focal | | 1 1.0|
Necrosis, Focal | 3 2 1 | 5 1.8|
__________________________________________________________________________|____________|
Pancreas | I + + + + + + + M + + + + + A + + + + + + + + A | 39 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + A | 43 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + I + + + + + + + + + A | 41 |
Hyperplasia, Focal, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A | 43 |
__________________________________________________________________________|____________|
Tooth | + + + | 3 |
Dysplasia | 2 3 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Thrombosis | X | 1 |
Coronary Artery, Mineralization | 1 | 1 1.0|
Myocardium, Fibrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5| | |
DAY ON TEST | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5| | |
| 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| | A |
6 MG/M3 | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Spindle Cell, Hyperplasia | 1 1 1 2 3 2 2 2 2 1 2 1 2 2 2 1 3 3 3 | 37 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
Hyperplasia, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 3 | 3 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + I + + M M + + + + + + + + + + + + + + M + + | 39 |
__________________________________________________________________________|____________|
Islets, Pancreatic | I I I M I I I I M + I + + + A + M + + + + + + A | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + M M + + + + M M M + M + M M M + + I | 21 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + M + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + I + + + + + + + | 46 |
Cyst | X | 1 |
Follicular Cell, Hyperplasia | 2 | 8 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + I A + + + + + + + + + + + + I + + I + + | 39 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 6 |
Dilatation | 3 3 2 3 | 6 2.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + I + + + + + + + + + + + + + + A | 43 |
Inflammation, Suppurative | 4 3 3 4 | 7 3.4|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + A + + + + + + + + + + + + + + + + + A | 43 |
Inflammation, Suppurative | | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + A + + + + + + + + + + + + + + + + + A | 44 |
Hypospermia | X X | 2 |
Inflammation, Suppurative | | 1 4.0|
Seminiferous Tubule, Degeneration, | | |
Focal | 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + A + + + A + + + A + + A + + + A | 42 |
Hyperplasia | | 1 3.0|
Myelofibrosis | | 2 1.0|
Myeloid Cell, Hyperplasia | 3 2 3 | 7 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5| | |
DAY ON TEST | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5| | |
| 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| | A |
6 MG/M3 | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Hyperplasia, Lymphoid | | 1 3.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Pancreatic, Inflammation, | | |
Granulomatous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + M + + + + + + M + + + + + + M + | 39 |
Hyperplasia, Histiocytic, Lymphoid | 1 | 1 1.0|
Hyperplasia, Histiocytic | 3 3 1 2 2 1 1 2 1 3 1 1 3 1 2 | 32 1.8|
Hyperplasia, Lymphoid | 1 1 4 2 2 1 | 10 1.6|
Infiltration Cellular, Mixed Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + M + + + M + + + M + M M + + M + M M M + | 23 |
Hyperplasia, Histiocytic | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + M M M + M M M M + + M M M M M M M M + + | 10 |
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + M | 39 |
Hyperplasia, Lymphoid | 4 | 3 3.0|
Infiltration Cellular, Mixed Cell | 2 3 3 2 3 2 2 2 1 1 3 3 1 2 | 20 2.3|
Inflammation, Granulomatous | 4 | 1 4.0|
Follicular, Necrosis | 2 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + A | 44 |
Hematocyst | X | 1 |
Hematopoietic Cell Proliferation | 2 4 2 2 | 7 2.3|
Hyperplasia, Lymphoid | | 2 2.5|
Inflammation, Granulomatous | 3 | 1 3.0|
Lymphoid Follicle, Depletion Lymphoid| 3 1 | 2 2.0|
Lymphoid Follicle, Necrosis | 2 2 | 5 2.6|
__________________________________________________________________________|____________|
Thymus | + + I + + I + + + + + M + + M + I + + + + + I + | 33 |
Cyst | X | 2 |
Inflammation, Granulomatous | 3 | 1 3.0|
Cortex, Depletion Lymphoid | 3 3 2 2 2 2 2 | 10 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M + M M M + M M M M M A | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 45 |
Abscess | 4 | 1 4.0|
Inflammation, Acute | 3 | 2 3.5|
Ulcer, Focal | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5| | |
DAY ON TEST | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5| | |
| 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| | A |
6 MG/M3 | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4| | L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Mineralization, Focal | 1 1 2 2 2 2 2 2 1 1 1 1 1 2 1 2 1 2 1 2 | 39 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + A | 41 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Congestion | | 1 3.0|
Hyperplasia, Macrophage | 2 1 2 2 2 1 3 1 1 1 2 2 1 1 1 1 2 1 1 2 1 1 2 1 | 46 1.4|
Inflammation, Chronic Active | 1 1 1 1 1 1 | 16 1.1|
Peribronchiolar, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A | 46 |
Cytoplasmic Alteration, Focal | 3 1 2 2 2 1 1 1 | 23 1.8|
Erosion, Focal | 1 | 1 1.0|
Inflammation, Acute | 1 | 4 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + M + + + + + + + + + + + + + + + + + + A | 43 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + A | 46 |
Hydronephrosis | | 1 4.0|
Inflammation, Focal, Suppurative | 4 4 2 | 5 3.6|
Metaplasia, Focal, Osseous | 1 1 1 | 3 1.0|
Pelvis, Inflammation, Suppurative | 4 2 3 | 5 3.4|
__________________________________________________________________________|____________|
Urinary Bladder | M + + + + A + + + + + + + + + + A + + + + + + A | 38 |
Inflammation, Chronic Active | 3 3 4 | 5 3.2|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|
| 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|
18 MG/M3 | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M M + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + A M + + + A + + + A + A + + + A + + A + + +|
Dilatation | |
Epithelium, Hyperplasia, Papillary | |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + A + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A A + + + + + + + A + A + + + A + + A + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + A + A + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + I M A M + + M + + + A + M + M I + + + A + + M|
__________________________________________________________________________|
Intestine Small | A + + A A + + + + + + + A + A + + + A + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + M M A + + + + + + + A + A + + + A + + A + + +|
Hyperplasia, Lymphoid | 2|
Mucosa, Atrophy | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + A A + + + A + + + A + A + + + A + + A + + +|
Hyperplasia, Lymphoid | 4 4 |
Mucosa, Atrophy | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A A + + + + + + + A + A + + + A + + A + + +|
Hyperplasia, Lymphoid | 2 |
Mucosa, Atrophy | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Focal Cellular Change | X X X X |
Inflammation, Focal | 1 |
Necrosis, Focal | 2 2 |
Pigmentation, Focal, Hemosiderin | |
Bile Duct, Hyperplasia, Focal | 2 |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Pancreas | + + M + + + + + + + I + + + + + + + + + + A + + +|
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Focal, Squamous | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Spindle Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 3 1 1 1 1 1 3 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +|
Vacuolization Cytoplasmic, Focal | 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|
| 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|
18 MG/M3 | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + I + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Islets, Pancreatic | I I M + I I I M + + I I + I + + + I + + + A + + M|
__________________________________________________________________________|
Parathyroid Gland | + + I M + + I M + M + M + + + M + + + + + A M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + I + + + + + + + + + + + + + + + + + A + + +|
Cyst | X |
Follicular Cell, Hyperplasia | 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + M + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Preputial Gland | + + + + |
Dilatation | 3 2 3 3 |
Inflammation | 4 |
__________________________________________________________________________|
Prostate | M + + + + + + + M + + + + + + + + + + + + A + + +|
Inflammation, Suppurative | 3 4 4 |
__________________________________________________________________________|
Seminal Vesicle | M + + + + + + + M + + + + + + + + + M + + A + + +|
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + A + + +|
Aspermatogenesis, Diffuse | 4 |
Atrophy, Diffuse | 4 |
Seminiferous Tubule, Degeneration, | |
Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + A A + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia | 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + M + + +|
Renal, Depletion Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + M + + +|
Abscess | |
Hyperplasia, Histiocytic | 2 3 1 4 4 4 3 2 3 2 2 2 2 2 3 2 1 3 3 4 4|
Hyperplasia, Lymphoid | 2 3 3 2 3 3 4 1 |
Infiltration Cellular, Mixed Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | I + + M M + + M I M M M + M M + + M M I M M + M +|
Hyperplasia, Lymphoid | |
Follicular, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M M M M M M M M M M + M M M + M + M M M M M M|
Hyperplasia, Histiocytic | 3 2 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|
| 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|
18 MG/M3 | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + M + + + + + + A + + +|
Depletion Lymphoid | 2 3 |
Hyperplasia, Lymphoid | 2 4 2|
Infiltration Cellular, Mixed Cell | 2 4 2 2 3 2 2|
Thrombosis | |
Follicular, Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hematopoietic Cell Proliferation | 2 4 2 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Mast Cell | 3 |
Lymphoid Follicle, Depletion Lymphoid| 1 3 |
Lymphoid Follicle, Necrosis | |
__________________________________________________________________________|
Thymus | M + + + + + + M + + + + + + + + + + M + + A + + M|
Cyst | |
Hyperplasia, Lymphoid | 2 |
Necrosis | 1 |
Cortex, Depletion Lymphoid | 3 3 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | I M + M I M M M M M M M M M + M + M M I M M + + I|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 3 2 2 1 1 1 2 1 2 1 2 2 2 2 1 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | 1 3 3 3 1 3 3 3 1 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3|
Inflammation, Chronic Active | 3 2 2 2 2 2 2 3 2 2 3 2 2 2 2 3 3 2 1 2|
Thrombosis | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + A + + +|
Cytoplasmic Alteration, Focal | 3 1 1 4 4 4 3 4 4 1 4 1 2 3 1 1 1 1 3|
Erosion, Focal | 1 1 |
Inflammation, Acute | 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + + + A + I +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|
| 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|
18 MG/M3 | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation, Focal, Suppurative | 3 |
Nephropathy, Chronic | 2 4 |
Capsule, Inflammation, Suppurative | |
Pelvis, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + A + + +|
Inflammation, Chronic Active | 3 3 |
Ulcer, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3| |
| 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| A |
18 MG/M3 | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Gallbladder | + I A + + M + M + + + + + A + + + + + + + + A +| 35 |
Dilatation | 3 | 1 3.0|
Epithelium, Hyperplasia, Papillary | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + A + A A + A + + + + + + + + + + + + + + A +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + A A + A + + + + + A + + + + + + + + A +| 37 |
Hyperplasia, Lymphoid | 3 3 | 3 2.7|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + A A + A + + + + + A + + + + + + + + A +| 39 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A M A A + A + + + + M + + + + + + + + + A +| 31 |
__________________________________________________________________________|____________|
Intestine Small | + + A + A A + A + + + + + A + + + + + + + + A +| 36 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + A A + A + + + + + A + + + + + + M + A +| 34 |
Hyperplasia, Lymphoid | | 1 2.0|
Mucosa, Atrophy | 2 4 | 3 2.7|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + A A + A + + + + + A + + + + + + + + A +| 35 |
Hyperplasia, Lymphoid | 2 3 2 | 5 3.0|
Mucosa, Atrophy | 2 3 4 | 4 2.8|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + A A + A + + + + + A + + + + + + + + A +| 36 |
Hyperplasia, Lymphoid | | 1 2.0|
Mucosa, Atrophy | 4 | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Abscess | 4 | 1 4.0|
Focal Cellular Change | X | 5 |
Inflammation, Focal | | 1 1.0|
Necrosis, Focal | 3 2 | 4 2.3|
Pigmentation, Focal, Hemosiderin | 3 | 1 3.0|
Bile Duct, Hyperplasia, Focal | | 1 2.0|
Serosa, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + A + A A + A + + + + + + + + + + + + + + + +| 42 |
Serosa, Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach | + + + + + A + A + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + A + + + + + + + + + + + + + + + +| 46 |
Hyperplasia, Focal, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + A A + A + + + + + + + + + + + + + + A +| 43 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3| |
| 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| A |
18 MG/M3 | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Spindle Cell, Hyperplasia | 2 2 2 1 1 2 2 1 2 2 2 1 2 2 1 2 1 2| 35 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Vacuolization Cytoplasmic, Focal | 2 | 4 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + + M A + + + + + + + I + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A M A A M A M + + I I + I + + + + + I M + +| 24 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M + + A M M M M M + M + + M + + + M + +| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + A + + + + + + + + + + + + + + + +| 46 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A + + + I + + + + + + + + + + + +| 45 |
Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 3 1 | 8 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + A + + A + + + + + + M + M + + + + + + M| 42 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 8 |
Dilatation | 3 3 2 3 | 8 2.8|
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + A + + + + + M + + + + + + + + + +| 44 |
Inflammation, Suppurative | 3 | 4 3.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + I A + A A + A + + + + + M + + + + + + + + + +| 39 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + A M + A + + + + + + + + + + + + + + + +| 45 |
Aspermatogenesis, Diffuse | | 1 4.0|
Atrophy, Diffuse | | 1 4.0|
Seminiferous Tubule, Degeneration, | | |
Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + A + A + + + + + + + + + + + + + + + +| 43 |
Hyperplasia | | 1 2.0|
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Renal, Depletion Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3| |
| 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| A |
18 MG/M3 | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + A + + + + + M + + + + M + + + + +| 44 |
Abscess | 2 | 1 2.0|
Hyperplasia, Histiocytic | 4 2 3 3 4 3 1 2 2 2 1 3 2 3 1 2 2 3 4 2 2| 42 2.5|
Hyperplasia, Lymphoid | 3 3 3 3 3 4 3 2 2 3 4 4 3 1 3| 23 2.8|
Infiltration Cellular, Mixed Cell | 3 2 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + M M M A M M + M + + M + + M + M M + + M| 19 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Follicular, Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + M M M M M M M M M M M M M M M + M M M M| 7 |
Hyperplasia, Histiocytic | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | I + + + A + + A + + + + + M + + + + + + + + M M| 40 |
Depletion Lymphoid | | 2 2.5|
Hyperplasia, Lymphoid | 3 2 3 | 6 2.7|
Infiltration Cellular, Mixed Cell | 3 3 2 3 2 2 | 13 2.5|
Thrombosis | X | 1 |
Follicular, Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Hematopoietic Cell Proliferation | 3 3 2 2 3 2 | 10 2.5|
Hyperplasia, Lymphoid | 2 4 | 3 2.7|
Hyperplasia, Mast Cell | | 1 3.0|
Lymphoid Follicle, Depletion Lymphoid| 2 3 3 | 5 2.4|
Lymphoid Follicle, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + M + + + + M + + I + +| 40 |
Cyst | X | 1 |
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis | 2 | 2 1.5|
Cortex, Depletion Lymphoid | 1 2 2 3 | 8 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + M M M M M M M M M M M M + M M M M M M M| 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + I + + + + + + + + + + + + +| 48 |
Alopecia | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3| |
| 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4| A |
18 MG/M3 | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Mineralization, Focal | 2 2 2 2 2 2 1 2 2 1 1 2 1 2 2 2 2 2| 38 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + A + + A + + + + + + + + + + + + + + + +| 46 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Congestion | 2 | 1 2.0|
Hyperplasia, Macrophage | 3 3 3 3 3 3 2 3 3 3 3 3 1 3 3 3 3 3 3 3 3 3 3| 48 2.8|
Inflammation, Chronic Active | 3 2 3 3 1 1 2 2 2 3 3 2 2 2 3 2 3 2 2 2| 40 2.2|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
Cytoplasmic Alteration, Focal | 3 2 2 3 2 3 3 1 3 3 2 1 3 4 3 2 3 4 3 2 3| 40 2.5|
Erosion, Focal | | 2 1.0|
Inflammation, Acute | 1 | 7 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + A M M A + + + + + + + + + + + + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Focal, Suppurative | 1 4 | 3 2.7|
Nephropathy, Chronic | | 2 3.0|
Capsule, Inflammation, Suppurative | 2 | 1 2.0|
Pelvis, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A A + A + + + + + + + + + + + + + + A +| 43 |
Inflammation, Chronic Active | | 2 3.0|
Ulcer, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 1| 1| 1| 7| 7| 5| 3| 3| 3| 7| 3| 7| 2| 1| 7| 7| 3| 6| 1| 5|
DAY ON TEST | 3| 4| 1| 3| 4| 8| 8| 8| 3| 3| 4| 6| 6| 6| 3| 6| 3| 9| 8| 3| 3| 6| 1| 8| 4|
| 9| 9| 5| 9| 9| 5| 5| 5| 9| 9| 9| 9| 8| 9| 9| 8| 9| 5| 5| 9| 9| 9| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 6| 6|
CONTROL | 2| 3| 5| 6| 8| 9| 3| 4| 7| 9| 0| 1| 4| 2| 8| 9| 0| 2| 3| 3| 6| 7| 9| 0| 1|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + I + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + +|
__________________________________________________________________________|
Pancreas | + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + M + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + M M + + + M +|
__________________________________________________________________________|
Testes | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + M + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + M +|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 5| 1| 1| 1| 7| 7| 5| 3| 3| 3| 7| 3| 7| 2| 1| 7| 7| 3| 6| 1| 5|
DAY ON TEST | 3| 4| 1| 3| 4| 8| 8| 8| 3| 3| 4| 6| 6| 6| 3| 6| 3| 9| 8| 3| 3| 6| 1| 8| 4|
| 9| 9| 5| 9| 9| 5| 5| 5| 9| 9| 9| 9| 8| 9| 9| 8| 9| 5| 5| 9| 9| 9| 9| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 6| 6|
CONTROL | 2| 3| 5| 6| 8| 9| 3| 4| 7| 9| 0| 1| 4| 2| 8| 9| 0| 2| 3| 3| 6| 7| 9| 0| 1|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + M M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + M +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + +|
__________________________________________________________________________|
Thymus | + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Mineralization, Focal | 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + +|
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
Inflammation, Chronic Active, Focal | 2 |
Cortex, Cyst | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7| | |
DAY ON TEST | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3| | |
| 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2| | A |
CONTROL | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 11 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + | 12 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + I + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + I + | 11 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 11 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 12 |
__________________________________________________________________________|____________|
Prostate | + + + + | 12 |
__________________________________________________________________________|____________|
Seminal Vesicle | + M + + | 8 |
__________________________________________________________________________|____________|
Testes | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7| | |
DAY ON TEST | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3| | |
| 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | T |
ANIMAL ID | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2| | A |
CONTROL | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M | 6 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 10 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 12 |
__________________________________________________________________________|____________|
Thymus | + + + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + | 3 |
__________________________________________________________________________|____________|
Skin | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 12 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 12 |
Mineralization, Focal | 2 2 2 | 5 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 12 |
__________________________________________________________________________|____________|
Lung | + + + + | 12 |
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 12 |
Inflammation, Chronic Active, Focal | | 1 2.0|
Cortex, Cyst | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 1| 3| 1| 7| 7| 1| 5| 3| 7| 3| 5| 1| 7| 5| 3| 1| 5| 3| 7| 5| 5| 3| 5| 7| 1|
DAY ON TEST | 7| 6| 8| 3| 3| 8| 4| 6| 3| 6| 4| 8| 3| 4| 6| 8| 4| 6| 3| 4| 5| 6| 4| 3| 8|
| 6| 9| 5| 9| 9| 5| 9| 8| 9| 9| 9| 5| 9| 9| 8| 5| 9| 9| 9| 9| 0| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| 9| 0|
6 MG/M3 | 2| 3| 6| 9| 1| 2| 3| 1| 4| 7| 9| 3| 4| 5| 2| 3| 7| 9| 0| 3| 1| 4| 7| 8| 2|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M M + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + M M + + + + + + +|
Spindle Cell, Hyperplasia | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + M M + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M M + + M + + + +|
__________________________________________________________________________|
Islets, Pancreatic | M + + + + M M + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + I + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + M + + M + + + + M|
__________________________________________________________________________|
Testes | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + +|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 1| 3| 1| 7| 7| 1| 5| 3| 7| 3| 5| 1| 7| 5| 3| 1| 5| 3| 7| 5| 5| 3| 5| 7| 1|
DAY ON TEST | 7| 6| 8| 3| 3| 8| 4| 6| 3| 6| 4| 8| 3| 4| 6| 8| 4| 6| 3| 4| 5| 6| 4| 3| 8|
| 6| 9| 5| 9| 9| 5| 9| 8| 9| 9| 9| 5| 9| 9| 8| 5| 9| 9| 9| 9| 0| 9| 9| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| 9| 0|
6 MG/M3 | 2| 3| 6| 9| 1| 2| 3| 1| 4| 7| 9| 3| 4| 5| 2| 3| 7| 9| 0| 3| 1| 4| 7| 8| 2|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + I I + + + + +|
Hyperplasia, Histiocytic | 1 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + + +|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M M + M M + M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M M + + + M|
Hyperplasia, Histiocytic | 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + +|
Mineralization, Focal | 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + +|
Hyperplasia, Macrophage | 1 1 1 1 1 1 1 1 2 |
Alveolus, Mineralization, Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | A |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + +|
Inflammation, Chronic Active, Focal | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1| | |
DAY ON TEST | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8| | |
| 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6| | A |
6 MG/M3 | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 12 |
__________________________________________________________________________|____________|
Liver | + + | 12 |
__________________________________________________________________________|____________|
Pancreas | + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + | 10 |
Spindle Cell, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + | 10 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 12 |
__________________________________________________________________________|____________|
Prostate | + + | 12 |
__________________________________________________________________________|____________|
Seminal Vesicle | + M | 8 |
__________________________________________________________________________|____________|
Testes | + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1| | |
DAY ON TEST | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8| | |
| 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6| | A |
6 MG/M3 | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 12 |
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 9 |
Hyperplasia, Histiocytic | | 4 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M | 9 |
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 9 |
Hyperplasia, Histiocytic | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + | 12 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M | 3 |
__________________________________________________________________________|____________|
Skin | + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 12 |
Mineralization, Focal | | 2 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 12 |
__________________________________________________________________________|____________|
Lung | + + | 12 |
Hyperplasia, Macrophage | 1 1 | 11 1.1|
Alveolus, Mineralization, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + | 12 |
Cytoplasmic Alteration, Focal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1| | |
DAY ON TEST | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8| | |
| 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6| | A |
6 MG/M3 | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 12 |
Inflammation, Chronic Active, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 1| 5| 5| 1| 1| 1| 7| 3| 5| 1| 3| 5| 1| 5| 5| 1| 7| 5| 7| 3| 1| 1| 1| 7| 5|
DAY ON TEST | 1| 4| 4| 1| 1| 8| 3| 6| 4| 8| 6| 4| 8| 6| 4| 8| 3| 5| 3| 6| 8| 4| 8| 3| 4|
| 3| 9| 9| 4| 4| 7| 9| 8| 9| 5| 8| 9| 5| 9| 9| 6| 9| 0| 9| 9| 6| 8| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 9| 9| 9| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 7| 7| 7|
18 MG/M3 | 1| 2| 8| 0| 1| 4| 2| 6| 8| 0| 2| 5| 3| 4| 5| 6| 7| 4| 1| 2| 3| 4| 5| 6| 8|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M|
__________________________________________________________________________|
Intestine Small | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + +|
Focal Cellular Change | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + +|
Spindle Cell, Hyperplasia | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + +|
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M M M M|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + M + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + M + M + M +|
__________________________________________________________________________|
Testes | + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
_____________________________________________________________________________________________________________________
| 1| 5| 5| 1| 1| 1| 7| 3| 5| 1| 3| 5| 1| 5| 5| 1| 7| 5| 7| 3| 1| 1| 1| 7| 5|
DAY ON TEST | 1| 4| 4| 1| 1| 8| 3| 6| 4| 8| 6| 4| 8| 6| 4| 8| 3| 5| 3| 6| 8| 4| 8| 3| 4|
| 3| 9| 9| 4| 4| 7| 9| 8| 9| 5| 8| 9| 5| 9| 9| 6| 9| 0| 9| 9| 6| 8| 6| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 9| 9| 9| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 7| 7| 7|
18 MG/M3 | 1| 2| 8| 0| 1| 4| 2| 6| 8| 0| 2| 5| 3| 4| 5| 6| 7| 4| 1| 2| 3| 4| 5| 6| 8|
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Histiocytic | 4 3 1 3 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M M M M |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + M + M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + M|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | M + + + + + + +|
__________________________________________________________________________|
Thymus | + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
Mineralization, Focal | 2 1 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + +|
Hyperplasia, Macrophage | 2 3 1 2 1 2 1 3|
Inflammation, Chronic Active | 1 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 1 1|
Cytoplasmic Alteration | |
__________________________________________________________________________|
Trachea | + + + + + M + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
Lumen, Calculus Micro Observation | |
Only | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3| | |
DAY ON TEST | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6| | |
| 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4| | A |
18 MG/M3 | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + M | 9 |
__________________________________________________________________________|____________|
Gallbladder | M + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + I | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + | 12 |
Focal Cellular Change | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 12 |
Spindle Cell, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 11 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 11 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 12 |
__________________________________________________________________________|____________|
Prostate | + + + + | 12 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 8 |
__________________________________________________________________________|____________|
Testes | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3| | |
DAY ON TEST | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6| | |
| 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4| | A |
18 MG/M3 | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + | 10 |
Hyperplasia, Histiocytic | 1 3 | 7 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + M | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 10 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 11 |
__________________________________________________________________________|____________|
Thymus | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 12 |
Mineralization, Focal | 1 | 5 1.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 12 |
__________________________________________________________________________|____________|
Lung | + + + + | 12 |
Hyperplasia, Macrophage | 1 1 2 2 | 12 1.8|
Inflammation, Chronic Active | 3 1 | 5 1.6|
__________________________________________________________________________|____________|
Nose | + + + + | 12 |
Cytoplasmic Alteration, Focal | 1 1 1 | 6 1.2|
Cytoplasmic Alteration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + M + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05079-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:10:35
__________________________________________________________________________________________________________________________________
| 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3| | |
DAY ON TEST | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6| | |
| 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4| | A |
18 MG/M3 | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 12 |
Lumen, Calculus Micro Observation | | |
Only | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
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