TDMS Study 05079-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TALC
NTP Experiment-Test: 05079-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 14807966
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 22 50 22 50 22
Scheduled Sacrifice 14 18 12
Early Deaths
Moribund Sacrifice 28 5 17 3 27 8
Natural Death 11 2 19 1 14 2
Survivors
Terminal Sacrifice 11 1 13 9
Missing 1
Animals Examined Microscopically 50 15 49 18 50 12
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (46) (15) (34) (18) (43) (12)
Hemorrhage, Focal 1 (3%)
Inflammation 11 (24%) 1 (3%) 6 (14%)
Parasite Metazoan 7 (15%) 2 (13%) 3 (9%) 6 (33%) 6 (14%) 4 (33%)
Ulcer 1 (2%) 1 (3%) 1 (2%)
Intestine Large, Colon (48) (15) (41) (18) (45) (12)
Inflammation 1 (2%) 2 (4%)
Parasite Metazoan 2 (4%) 2 (13%) 3 (7%) 3 (7%) 1 (8%)
Intestine Large, Rectum (38) (15) (37) (18) (41) (12)
Inflammation 4 (11%)
Parasite Metazoan 2 (5%) 1 (3%) 1 (2%)
Intestine Small, Duodenum (48) (15) (44) (18) (47) (12)
Necrosis, Focal 1 (2%)
Intestine Small, Ileum (44) (15) (32) (18) (38) (12)
Hyperplasia, Lymphoid 2 (5%)
Liver (50) (15) (48) (18) (50) (12)
Atrophy 1 (2%) 1 (2%)
Basophilic Focus 27 (54%) 2 (13%) 17 (35%) 4 (22%) 21 (42%) 2 (17%)
Clear Cell Focus 1 (2%) 2 (4%) 1 (2%)
Cyst Multilocular 1 (2%)
Degeneration, Cystic 2 (4%) 1 (2%)
Eosinophilic Focus 2 (4%) 2 (13%) 5 (10%) 4 (8%)
Fatty Change 18 (36%) 1 (7%) 18 (38%) 1 (6%) 14 (28%)
Fibrosis, Focal 1 (8%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (7%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic 1 (7%) 1 (6%) 1 (8%)
Inflammation, Focal, Granulomatous 13 (26%) 3 (6%) 4 (8%)
Inflammation, Focal, Necrotizing 1 (2%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis, Focal 5 (10%) 1 (2%) 2 (4%)
Pigmentation, Hemosiderin 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 36 (72%) 7 (47%) 38 (79%) 8 (44%) 36 (72%) 4 (33%)
Centrilobular, Atrophy 2 (4%) 6 (12%)
Centrilobular, Degeneration 10 (20%) 14 (29%) 10 (20%)
Centrilobular, Necrosis 2 (4%) 2 (4%) 2 (4%)
Hepatocyte, Atrophy, Focal 1 (2%)
Serosa, Thrombosis 3 (6%)
Mesentery (1) (2)
Granuloma 1 (100%) 1 (50%)
Inflammation, Chronic Active 1 (50%)
Pancreas (50) (15) (46) (18) (49) (12)
Hyperplasia, Nodular 1 (2%)
Inflammation 1 (2%) 1 (6%)
Lobules, Atrophy 7 (14%) 1 (7%) 7 (15%) 9 (18%)
Salivary Glands (50) (15) (48) (18) (50) (12)
Inflammation 2 (4%)
Stomach, Forestomach (50) (15) (45) (17) (49) (12)
Hyperkeratosis 1 (2%) 1 (2%)
Hyperplasia, Squamous 1 (6%)
Inflammation 1 (2%) 2 (4%)
Mineralization 1 (2%)
Ulcer 9 (18%) 4 (9%) 3 (6%)
Stomach, Glandular (50) (15) (47) (17) (50) (12)
Erosion 1 (2%)
Inflammation 1 (2%) 1 (2%)
Mineralization 2 (4%) 2 (4%) 2 (4%)
Ulcer 3 (6%) 2 (4%) 3 (6%)
Ulcer, Multiple 1 (2%) 1 (2%)
Arteriole, Muscularis, Lamina Propria,
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (3) (1)
Aorta, Mineralization 3 (100%) 1 (100%)
Mesenteric Artery, Aneurysm 1 (33%)
Mesenteric Artery, Inflammation 3 (100%)
Mesenteric Artery, Mineralization 1 (33%) 1 (100%)
Mesenteric Artery, Thrombosis 1 (33%) 1 (33%)
Heart (50) (15) (48) (18) (50) (12)
Cardiomyopathy 35 (70%) 6 (40%) 40 (83%) 8 (44%) 36 (72%) 3 (25%)
Inflammation, Focal 1 (2%) 1 (2%)
Atrium, Thrombosis 5 (10%) 8 (17%) 5 (10%)
Myocardium, Embolus 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Myocardium, Inflammation, Focal 1 (2%)
Myocardium, Mineralization 1 (2%) 4 (8%) 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (14) (47) (16) (49) (12)
Congestion 1 (7%) 1 (6%)
Degeneration, Cystic 1 (2%) 1 (7%)
Degeneration, Fatty 3 (6%) 1 (6%)
Degeneration, Focal 1 (2%) 1 (2%)
Hyperplasia, Diffuse 1 (2%) 1 (2%)
Hyperplasia, Focal 9 (18%) 12 (26%) 13 (27%)
Necrosis 2 (4%)
Necrosis, Focal 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Vacuolization Cytoplasmic 1 (7%)
Adrenal Gland, Medulla (48) (14) (47) (18) (49) (11)
Cyst 1 (2%)
Hyperplasia 20 (42%) 3 (21%) 18 (38%) 1 (6%) 14 (29%) 1 (9%)
Bilateral, Hyperplasia 2 (4%) 2 (4%) 2 (4%)
Parathyroid Gland (43) (12) (42) (15) (47) (8)
Cyst 1 (7%)
Hyperplasia 3 (7%) 4 (10%) 2 (4%)
Bilateral, Hyperplasia 1 (2%)
Pituitary Gland (50) (15) (47) (18) (50) (12)
Cyst 2 (4%) 1 (6%) 1 (2%)
Pars Distalis, Hyperplasia 10 (20%) 6 (13%) 4 (8%) 1 (8%)
Pars Distalis, Necrosis 1 (2%)
Thyroid Gland (50) (13) (47) (18) (49) (11)
C-Cell, Hyperplasia 10 (20%) 4 (31%) 8 (17%) 2 (11%) 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (15) (44) (16) (46) (12)
Fibrosis 1 (6%)
Hyperplasia 2 (4%) 1 (2%)
Inflammation 1 (2%) 1 (2%) 1 (2%)
Ovary (50) (15) (47) (18) (50) (12)
Cyst 5 (10%) 1 (7%) 1 (2%)
Uterus (50) (15) (48) (18) (50) (12)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Cystic 1 (6%)
Inflammation 1 (2%) 1 (2%)
Endometrium, Hyperplasia 3 (6%)
Lamina Propria, Fibrosis 20 (40%) 39 (81%) 19 (38%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (15) (43) (18) (49) (12)
Atrophy 1 (2%) 2 (5%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%) 1 (7%) 2 (11%) 1 (2%) 2 (17%)
Inflammation, Focal, Granulomatous 1 (2%)
Myelofibrosis 1 (2%) 3 (7%) 3 (6%)
Necrosis, Focal 1 (2%)
Femoral, Hyperplasia, Histiocytic 1 (6%)
Myeloid Cell, Hyperplasia 2 (4%) 2 (5%) 1 (6%) 3 (6%) 1 (8%)
Lymph Node (50) (15) (48) (18) (50) (12)
Axillary, Hemorrhage, Chronic 1 (2%)
Renal, Hyperplasia, Histiocytic 1 (6%)
Lymph Node, Bronchial (46) (10) (47) (18) (47) (9)
Cyst 1 (2%)
Fibrosis 1 (2%)
Hemorrhage, Chronic 1 (2%)
Hyperplasia, Histiocytic 40 (85%) 18 (100%) 45 (96%) 8 (89%)
Hyperplasia, Lymphoid 1 (10%)
Inflammation, Suppurative 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (10%)
Lymph Node, Mandibular (47) (9) (46) (14) (47) (11)
Congestion 1 (9%)
Hyperplasia, Lymphoid 1 (2%) 2 (14%) 1 (2%) 1 (9%)
Hyperplasia, Plasma Cell 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Lymph Node, Mediastinal (47) (11) (44) (17) (47) (12)
Congestion 2 (18%) 1 (6%) 1 (8%)
Hemorrhage, Chronic 1 (2%)
Hyperplasia, Histiocytic 33 (75%) 14 (82%) 40 (85%) 9 (75%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 2 (18%)
Lymph Node, Mesenteric (49) (14) (47) (18) (47) (12)
Edema 1 (6%)
Hemorrhage 1 (2%)
Hyperplasia, Histiocytic 1 (7%) 1 (6%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%) 1 (6%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Plasma Cell 1 (2%)
Inflammation, Chronic Active 4 (8%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Spleen (50) (15) (48) (18) (50) (12)
Atrophy 2 (4%) 2 (4%) 2 (4%)
Fibrosis, Focal 3 (6%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 6 (13%) 1 (6%) 7 (14%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
Pigmentation, Hemosiderin 2 (4%)
Capsule, Hemorrhage 1 (2%)
Thymus (47) (14) (44) (15) (47) (12)
Cyst 1 (7%)
Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (15) (48) (18) (50) (12)
Galactocele 1 (2%)
Hyperplasia, Cystic 2 (13%) 2 (4%) 1 (6%)
Lobules, Hyperplasia 2 (13%) 1 (2%)
Skin (50) (15) (49) (18) (50) (12)
Inflammation, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (15) (48) (18) (50) (12)
Fibrous Osteodystrophy 4 (8%) 3 (6%) 4 (8%)
Hyperostosis 4 (8%) 1 (2%) 3 (6%)
Femur, Hyperplasia 1 (7%)
Pelvis, Fracture 1 (2%)
Vertebra, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (15) (48) (18) (50) (12)
Compression 8 (16%) 1 (7%) 7 (15%) 9 (18%)
Hemorrhage 1 (2%) 1 (2%)
Hydrocephalus 1 (2%)
Inflammation, Focal 1 (2%)
White Matter, Necrosis, Focal 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (15) (48) (18) (48) (12)
Inflammation, Necrotizing 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%)
Lung (50) (15) (48) (18) (50) (12)
Crystals, Focal 1 (2%)
Cyst 1 (2%) 5 (10%)
Cyst, Multiple 2 (4%)
Edema 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Diffuse, Adenomatous 2 (4%)
Inflammation, Chronic Active 1 (7%)
Inflammation, Granulomatous 2 (4%) 1 (7%) 47 (98%) 18 (100%) 50 (100%) 12 (100%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Mineralization 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%) 2 (13%) 27 (56%) 16 (89%) 47 (94%) 10 (83%)
Alveolus, Metaplasia, Squamous 8 (16%)
Bronchus, Epithelium, Degeneration, Focal 1 (2%)
Interstitium, Fibrosis 1 (2%)
Interstitium, Fibrosis, Focal 1 (2%) 24 (50%) 13 (72%) 44 (88%) 9 (75%)
Interstitium, Mineralization 1 (2%) 1 (2%)
Peribronchial, Hyperplasia, Histiocytic 8 (17%) 5 (28%) 9 (18%) 6 (50%)
Nose (48) (15) (45) (18) (48) (12)
Inflammation, Suppurative 1 (2%)
Lumen, Foreign Body 1 (2%)
Mucosa, Inflammation, Suppurative 3 (7%) 5 (10%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Nerve, Developmental Malformation 1 (2%)
Olfactory Epithelium, Metaplasia 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Trachea (50) (15) (48) (18) (50) (12)
Inflammation, Necrotizing 1 (2%)
Inflammation, Suppurative 3 (6%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2)
Cataract 2 (100%) 2 (100%)
Retina, Degeneration 2 (100%) 2 (100%)
Harderian Gland (5) (7) (1) (15)
Inflammation 4 (80%) 3 (43%) 3 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (15) (47) (18) (49) (12)
Abscess 1 (2%)
Cyst 1 (2%) 1 (2%)
Cyst, Multiple 1 (2%)
Embolus, Multiple 1 (2%)
Infarct 1 (2%)
Infarct, Multiple 1 (2%)
Inflammation 1 (2%) 1 (2%)
Nephropathy 44 (90%) 9 (60%) 43 (91%) 12 (67%) 42 (86%) 6 (50%)
Capsule, Inflammation 1 (2%)
Medulla, Inflammation 1 (2%) 1 (2%)
Renal Tubule, Necrosis 1 (2%) 2 (4%)
Urinary Bladder (50) (15) (45) (18) (50) (12)
Inflammation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 22 50 22 50 22
Scheduled Sacrifice 11 15 10
Early Deaths
Moribund Sacrifice 23 9 19 5 20 6
Natural Death 18 2 17 2 14 6
Survivors
Terminal Sacrifice 1
Terminal Sacrifice 8 11 13
Natural Death 1 2 3
Animals Examined Microscopically 49 11 50 15 50 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (10) (50) (10) (49) (9)
Inflammation 1 (2%)
Intestine Large, Cecum (42) (11) (38) (15) (37) (10)
Hemorrhage 1 (3%)
Inflammation 9 (21%) 2 (5%) 5 (14%)
Parasite Metazoan 3 (7%) 4 (36%) 4 (11%) 6 (40%) 4 (11%) 4 (40%)
Ulcer 1 (2%)
Intestine Large, Colon (43) (11) (43) (15) (46) (10)
Hyperplasia, Lymphoid 1 (2%)
Inflammation 1 (2%) 1 (2%)
Mineralization 1 (2%)
Parasite Metazoan 2 (5%) 1 (9%) 1 (2%) 1 (7%) 1 (2%)
Intestine Large, Rectum (38) (11) (41) (15) (34) (10)
Inflammation 6 (16%) 1 (2%) 1 (3%)
Metaplasia, Focal, Squamous 1 (3%)
Parasite Metazoan 1 (9%) 2 (5%)
Intestine Small, Duodenum (48) (11) (44) (15) (46) (10)
Inflammation 1 (2%)
Mineralization 1 (2%)
Necrosis, Focal 1 (2%)
Ulcer 1 (2%) 1 (2%)
Intestine Small, Ileum (39) (11) (34) (15) (35) (10)
Hyperplasia, Lymphoid 1 (3%) 2 (6%)
Lymphatic, Ectasia 1 (3%)
Peyer's Patch, Hyperplasia, Focal, Lymphoid 1 (7%)
Liver (49) (11) (50) (15) (48) (10)
Angiectasis, Focal 1 (2%)
Atrophy 1 (2%)
Basophilic Focus 18 (37%) 2 (18%) 18 (36%) 4 (27%) 19 (40%) 4 (40%)
Clear Cell Focus 3 (6%) 7 (14%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Congestion 1 (2%) 1 (10%)
Degeneration, Cystic 9 (18%) 17 (34%) 9 (19%)
Degeneration, Diffuse 1 (2%)
Eosinophilic Focus 2 (4%) 7 (14%) 7 (15%)
Fatty Change 16 (33%) 1 (9%) 14 (28%) 12 (25%)
Fibrosis 1 (2%)
Hematocyst 1 (2%)
Hyperplasia, Focal 1 (9%) 1 (2%)
Inflammation, Focal, Granulomatous 3 (6%) 1 (2%)
Inflammation, Focal, Necrotizing 1 (2%)
Inflammation, Focal, Subacute 1 (7%)
Necrosis, Coagulative, Multifocal 1 (9%)
Necrosis, Focal 3 (6%) 1 (2%)
Thrombosis 1 (2%) 1 (9%)
Bile Duct, Hyperplasia 39 (80%) 5 (45%) 46 (92%) 9 (60%) 44 (92%) 3 (30%)
Centrilobular, Atrophy 9 (18%) 4 (8%) 7 (15%)
Centrilobular, Degeneration 8 (16%) 12 (24%) 9 (19%)
Centrilobular, Degeneration, Fatty 1 (2%)
Centrilobular, Necrosis 5 (10%) 2 (4%)
Mesentery (2) (1)
Inflammation 1 (100%)
Pancreas (48) (11) (46) (15) (47) (10)
Lobules, Atrophy 11 (23%) 7 (15%) 8 (17%)
Salivary Glands (49) (11) (50) (15) (50) (10)
Inflammation 1 (2%)
Necrosis 1 (2%)
Stomach, Forestomach (49) (10) (47) (15) (47) (10)
Hyperkeratosis 1 (2%)
Inflammation 1 (2%)
Mineralization 1 (2%) 4 (9%) 1 (2%)
Ulcer 5 (10%) 5 (11%) 8 (17%)
Stomach, Glandular (49) (10) (47) (15) (47) (10)
Mineralization 6 (12%) 6 (13%) 6 (13%)
Ulcer 3 (6%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (4) (5) (5)
Aorta, Mineralization 3 (75%) 5 (100%) 4 (80%)
Mesenteric Artery, Aneurysm 2 (40%)
Mesenteric Artery, Inflammation 1 (20%)
Mesenteric Artery, Mineralization 3 (75%) 5 (100%) 3 (60%)
Mesenteric Artery, Thrombosis 1 (25%) 1 (20%) 1 (20%)
Heart (49) (11) (50) (15) (50) (10)
Cardiomyopathy 42 (86%) 6 (55%) 47 (94%) 8 (53%) 50 (100%) 3 (30%)
Atrium, Thrombosis 9 (18%) 5 (10%) 11 (22%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Epicardium, Hyperplasia 1 (2%)
Myocardium, Inflammation 1 (2%)
Myocardium, Mineralization 2 (4%) 6 (12%) 5 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (11) (49) (15) (48) (10)
Degeneration 1 (2%)
Degeneration, Fatty 8 (16%) 2 (4%)
Degeneration, Focal 1 (2%)
Hyperplasia, Diffuse 2 (4%)
Hyperplasia, Focal 11 (22%) 4 (8%) 1 (7%) 9 (19%)
Necrosis, Focal 1 (2%)
Adrenal Gland, Medulla (49) (10) (48) (15) (47) (10)
Hyperplasia 19 (39%) 1 (10%) 8 (17%) 3 (20%) 8 (17%)
Bilateral, Hyperplasia 1 (2%) 1 (10%) 1 (2%)
Islets, Pancreatic (47) (9) (41) (15) (43) (10)
Hyperplasia 1 (7%) 1 (2%)
Parathyroid Gland (45) (6) (45) (7) (46) (8)
Hyperplasia 6 (13%) 1 (17%) 11 (24%) 12 (26%)
Bilateral, Hyperplasia 1 (2%)
Pituitary Gland (47) (11) (50) (14) (49) (10)
Angiectasis, Focal 1 (2%)
Cyst 1 (2%) 1 (7%) 1 (2%) 1 (10%)
Pars Distalis, Hyperplasia 8 (17%) 1 (9%) 8 (16%) 7 (14%)
Pars Nervosa, Hyperplasia 1 (2%)
Thyroid Gland (45) (11) (46) (13) (46) (8)
C-Cell, Hyperplasia 5 (11%) 1 (9%) 7 (15%) 2 (15%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (9) (50) (15) (49) (10)
Spermatocele 1 (2%)
Preputial Gland (48) (11) (49) (15) (48) (8)
Hyperplasia 3 (6%) 1 (2%)
Inflammation 7 (15%) 2 (4%) 5 (10%)
Prostate (49) (10) (45) (15) (48) (10)
Atrophy 1 (2%) 1 (2%)
Inflammation 22 (45%) 1 (10%) 14 (31%) 1 (7%) 19 (40%) 1 (10%)
Seminal Vesicle (49) (11) (48) (15) (47) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Atrophy 1 (2%)
Inflammation 1 (2%)
Testes (49) (11) (50) (15) (50) (10)
Atrophy 14 (29%) 11 (22%) 1 (7%) 16 (32%) 1 (10%)
Cyst 1 (9%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
Interstitial Cell, Hyperplasia 2 (4%) 1 (2%) 1 (7%) 3 (6%)
Serosa, Proliferation 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (11) (48) (15) (47) (10)
Atrophy 2 (4%)
Atrophy, Focal 1 (2%)
Hyperplasia, Histiocytic 2 (13%)
Inflammation 1 (2%)
Myelofibrosis 1 (2%) 1 (2%)
Myeloid Cell, Hyperplasia 2 (4%) 1 (9%) 3 (6%) 6 (13%)
Lymph Node (49) (11) (50) (15) (50) (10)
Hemorrhage, Chronic 1 (2%)
Pancreatic, Atrophy 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Bronchial (41) (9) (48) (15) (49) (10)
Atrophy 2 (5%)
Hemorrhage 1 (2%)
Hemorrhage, Acute 1 (2%)
Hemorrhage, Chronic 4 (10%)
Hyperplasia, Histiocytic 44 (92%) 12 (80%) 46 (94%) 10 (100%)
Lymph Node, Mandibular (46) (10) (48) (12) (47) (9)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (10%) 2 (4%) 1 (8%) 1 (11%)
Hyperplasia, Plasma Cell 2 (4%) 5 (11%)
Inflammation, Chronic Active 2 (4%)
Lymph Node, Mediastinal (48) (11) (49) (11) (47) (10)
Atrophy 1 (2%)
Congestion 1 (9%) 1 (10%)
Hemorrhage 3 (6%)
Hemorrhage, Acute 1 (2%)
Hemorrhage, Chronic 6 (13%)
Hyperplasia, Histiocytic 40 (82%) 8 (73%) 43 (91%) 7 (70%)
Pigmentation, Hemosiderin 1 (2%)
Lymph Node, Mesenteric (49) (10) (48) (15) (47) (10)
Atrophy 1 (2%)
Depletion Lymphoid 1 (10%)
Hemorrhage 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage, Acute 1 (2%)
Hyperplasia, Histiocytic 2 (13%)
Hyperplasia, Lymphoid 1 (2%) 2 (20%) 2 (4%) 3 (6%)
Hyperplasia, Plasma Cell 1 (2%)
Inflammation, Chronic Active 1 (2%)
Spleen (49) (11) (50) (15) (48) (10)
Atrophy 1 (2%) 2 (4%) 1 (10%)
Autolysis 1 (2%)
Congestion, Acute 1 (9%)
Congestion, Chronic 1 (2%)
Cyst 1 (2%)
Fibrosis 1 (2%)
Fibrosis, Focal 5 (10%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 3 (6%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Infarct 3 (6%) 1 (7%)
Inflammation, Focal, Granulomatous 1 (2%) 1 (2%)
Thymus (48) (11) (40) (13) (43) (9)
Atrophy 1 (9%) 2 (5%)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (10) (48) (11) (50) (9)
Galactocele 1 (2%)
Hyperplasia, Cystic 1 (9%)
Lobules, Hyperplasia 1 (11%)
Skin (48) (11) (50) (15) (50) (10)
Cyst Epithelial Inclusion 1 (2%)
Subcutaneous Tissue, Inflammation 1 (2%)
Tail, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (11) (50) (15) (50) (10)
Fibrous Osteodystrophy 3 (6%) 4 (8%) 5 (10%)
Coccygeal, Necrosis 1 (2%)
Pelvis, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (11) (50) (15) (50) (10)
Compression 5 (10%) 2 (4%) 2 (4%)
Hemorrhage 1 (2%)
Infarct 1 (2%)
Necrosis, Focal 1 (2%) 2 (4%)
Spinal Cord (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (48) (11) (49) (15) (49) (10)
Inflammation, Suppurative 6 (13%)
Lung (49) (11) (50) (15) (50) (10)
Congestion 1 (2%)
Crystals, Focal 1 (2%)
Cyst 3 (6%)
Hemorrhage, Chronic 2 (4%)
Infarct 1 (2%)
Inflammation, Granulomatous 2 (4%) 1 (9%) 50 (100%) 15 (100%) 49 (98%) 10 (100%)
Inflammation, Suppurative 2 (4%)
Mineralization 4 (8%)
Alveolar Epithelium, Hyperplasia 5 (10%) 1 (9%) 26 (52%) 12 (80%) 38 (76%) 7 (70%)
Alveolus, Hemorrhage, Focal 1 (2%)
Alveolus, Metaplasia, Squamous 2 (4%)
Artery, Thrombosis 1 (2%)
Interstitium, Fibrosis, Focal 1 (2%) 16 (32%) 10 (67%) 33 (66%) 7 (70%)
Interstitium, Mineralization 2 (4%) 1 (2%) 4 (8%)
Peribronchial, Hyperplasia, Histiocytic 12 (24%) 4 (27%) 8 (16%) 5 (50%)
Nose (49) (11) (48) (15) (47) (10)
Inflammation, Suppurative 2 (4%) 1 (9%) 1 (2%)
Lumen, Foreign Body 1 (2%)
Lumen, Hemorrhage 1 (2%)
Mucosa, Inflammation, Suppurative 4 (8%) 5 (10%) 2 (4%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Respiratory Epithelium, Hyperplasia 3 (6%) 14 (30%) 1 (10%)
Trachea (49) (11) (50) (15) (48) (10)
Inflammation, Suppurative 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2) (2)
Cataract 1 (33%) 1 (50%) 2 (100%)
Inflammation, Chronic 1 (50%)
Cornea, Inflammation, Necrotizing 1 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05079-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TALC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:10:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 6 MG/M3 6 MG/M3 18 MG/M3 18 MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Cornea, Necrosis 1 (33%)
Lens, Cataract 1 (33%)
Retina, Degeneration 2 (67%) 1 (50%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (11) (49) (15) (48) (10)
Calculus Micro Observation Only 1 (2%)
Cyst 3 (6%) 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Inflammation, Chronic 1 (9%)
Nephropathy 45 (92%) 4 (36%) 47 (96%) 9 (60%) 43 (90%) 3 (30%)
Medulla, Inflammation 1 (2%) 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Ureter (1)
Calculus Micro Observation Only 1 (100%)
Urethra (1)
Fibrosis 1 (100%)
Urinary Bladder (49) (11) (48) (15) (47) (9)
Calculus Gross Observation 1 (2%)
Calculus Gross Observation, Single 1 (9%)
Calculus Micro Observation Only 1 (7%)
Inflammation 1 (2%)
Mucosa, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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