TDMS Study 05079-01 Pathology Tables
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 14807966
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|
DAY ON TEST | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|
| 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M M + + + + + + + + + + + + + + + + M + + + + M +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + I + + + + + + + M + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Carcinoma | X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Carcinoma | |
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|
DAY ON TEST | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|
| 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + M + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + + + + + M + + + +|
Adenocarcinoma, Metastatic, Thyroid | |
Gland | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + M + + + + + + + + +|
Adenocarcinoma, Metastatic, Thyroid | |
Gland | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X |
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenoma | |
Fibroadenoma | X X X X |
Fibroma | X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandible, Sarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|
DAY ON TEST | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|
| 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Benign | X |
Carcinoma, Metastatic, Pituitary | |
Gland | X X|
Ependymoma Malignant | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Thyroid | |
Gland | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Multiple, Metastatic,| |
Mammary Gland | |
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5| |
DAY ON TEST | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8| |
| 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
CONTROL | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + M + + M + + + + + M M + + + M + + + A A| 38 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + A + + + + A + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + A A +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 11 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X | 2 |
Pheochromocytoma Benign | X X X X X | 13 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + M + M + + + + + + M + M + + + + + + M +| 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X X X X X X X X X| 19 |
Pars Distalis, Carcinoma | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5| |
DAY ON TEST | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8| |
| 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
CONTROL | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Bilateral, C-Cell, Carcinoma | X | 1 |
C-Cell, Adenoma | X X | 5 |
C-Cell, Carcinoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
Carcinoma | X X | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa Cell Tumor Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp Stromal | X | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lumbar, Leukemia Mononuclear | X | 1 |
Pancreatic, Leukemia Mononuclear | X | 1 |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + + + + + M + + + + + + + + + + + +| 46 |
Adenocarcinoma, Metastatic, Thyroid | | |
Gland | X | 1 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + M + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Adenocarcinoma, Metastatic, Thyroid | | |
Gland | X | 1 |
Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 13 |
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + M +| 47 |
Leukemia Mononuclear | | 1 |
Thymoma Benign | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5| |
DAY ON TEST | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8| |
| 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
CONTROL | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X| 2 |
Adenoma | X | 1 |
Fibroadenoma | X X X X X X X | 11 |
Fibroma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mandible, Sarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Benign | | 1 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 2 |
Ependymoma Malignant | | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma, Metastatic, Thyroid | | |
Gland | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma, Multiple, Metastatic,| | |
Mammary Gland | X| 1 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X X X X X | 7 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5| |
DAY ON TEST | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8| |
| 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
CONTROL | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|
DAY ON TEST | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|
| 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|
6 MG/M3 | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + A + + + + A + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + A + + A A + + + + A + A + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + A + + A A + + + + A + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + M + + + M + M M + A + + + + M + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + A + + + + A + + A A + + + + A + + + + A A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + A + + A A + + + + A + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hepatocellular Carcinoma | |
Leukemia Mononuclear | X X X X X X |
Lymphoma Malignant Lymphocytic | X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + M + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + A + + + + + + + +|
Lymphoma Malignant Lymphocytic, | |
Metastatic | X |
Sarcoma | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + M + + + + + + + + + + A M + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + |
Sarcoma, Metastatic | X |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Tooth | |
Adamantinoma Benign | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|
DAY ON TEST | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|
| 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|
6 MG/M3 | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X X X X X X|
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + A + M + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + A + + + + I + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X|
Pars Distalis, Carcinoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + M + + + + + A + M + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + A + + + + + + + +|
Granulosa Cell Tumor Benign | |
Granulosa-Theca Tumor Benign | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic, | |
Metastatic | X |
Polyp Stromal | X X X X |
Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + A + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + A + + + + + + + +|
Pancreatic, Leukemia Mononuclear | |
Pancreatic, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + A + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|
DAY ON TEST | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|
| 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|
6 MG/M3 | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sarcoma, Metastatic | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + M + + A M + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + A + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | X |
Mixed Tumor Malignant | |
Myxoma | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Fibroadenoma | X X X X X X X |
Fibroma | X |
Lymphoma Malignant Lymphocytic, | |
Metastatic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + A + + + + + + + +|
Mandible, Sarcoma, Metastatic | X |
__________________________________________________________________________|
Skeletal Muscle | |
Liposarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + A + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|
DAY ON TEST | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|
| 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|
6 MG/M3 | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
Lipoma | |
Lymphoma Malignant Lymphocytic, | |
Metastatic | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8| |
| 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| A |
6 MG/M3 | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + A + + + A + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + A + A + A + A + + + + + A + + A A| 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + A + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + M + A + + + A + M + + + + + + + +| 37 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + A + + + A M + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + A A A + + + A + A + + + A + + A A| 32 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + A + + + A + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hepatocellular Carcinoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X | 15 |
Lymphoma Malignant Lymphocytic | | 1 |
Neoplastic Nodule | X X X | 3 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + +| 46 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Lymphocytic, | | |
Metastatic | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + +| 45 |
Leukemia Mononuclear | X X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Tongue | + | 2 |
Sarcoma, Metastatic | | 1 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Adamantinoma Benign | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 3 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8| |
| 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| A |
6 MG/M3 | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X | 5 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X X | 10 |
Bilateral, Pheochromocytoma Benign | X X X| 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + +| 45 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + M + + + I + + M +| 42 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + I + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 2 |
Pars Distalis, Adenoma | X X X X X X X X X X X| 18 |
Pars Distalis, Carcinoma | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 1 |
C-Cell, Carcinoma | | 2 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
Granulosa Cell Tumor Benign | X X | 2 |
Granulosa-Theca Tumor Benign | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Lymphoma Malignant Lymphocytic, | | |
Metastatic | | 1 |
Polyp Stromal | X X X | 7 |
Sarcoma Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A A + + A + + + + + + + + + + + + A +| 43 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pancreatic, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8| |
| 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| A |
6 MG/M3 | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X | 5 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + A + + + + + + + + M + + + + +| 46 |
Leukemia Mononuclear | X X X X | 5 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + + + + + + + + +| 44 |
Leukemia Mononuclear | X X X X | 6 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X X X X | 8 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X X X X X X X | 19 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + I M M + + + + + + + + + + + + + + + + + +| 44 |
Leukemia Mononuclear | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
Mixed Tumor Malignant | X | 1 |
Myxoma | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Adenoma | X X | 2 |
Fibroadenoma | X X X | 10 |
Fibroma | | 1 |
Lymphoma Malignant Lymphocytic, | | |
Metastatic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Keratoacanthoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8| |
| 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| A |
6 MG/M3 | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mandible, Sarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Liposarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X | 9 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + A + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 2 |
Lipoma | X | 1 |
Lymphoma Malignant Lymphocytic, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + M M + + + + +| 45 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X X X | 20 |
Lymphoma Malignant Lymphocytic | X | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|
DAY ON TEST | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|
| 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|
18 MG/M3 | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + A + + M + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + M + M M A|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + A + + + A + A A + + + A + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Malignant, | |
Metastatic, Ovary | X |
Leukemia Mononuclear | X X X X X X X |
Neoplastic Nodule | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pharynx | + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Malignant, | |
Metastatic, Ovary | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + A|
Granulosa-Theca Tumor Malignant, | |
Metastatic, Ovary | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + A|
Granulosa-Theca Tumor Malignant, | |
Metastatic, Ovary | X |
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|
DAY ON TEST | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|
| 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|
18 MG/M3 | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X X X X X |
Bilateral, Pheochromocytoma Malignant| X |
Bilateral, Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, Granulosa-Theca Tumor | |
Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Lung | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|
DAY ON TEST | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|
| 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|
18 MG/M3 | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Primary Site | |
Fibrosarcoma, Metastatic, Skin | X |
Granulosa-Theca Tumor Malignant, | |
Metastatic, Ovary | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + M + +|
Leukemia Mononuclear | X X X |
Schwannoma Benign | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Adenoma | |
Fibroadenoma | X X X X X X |
Fibrosarcoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Granulosa-Theca Tumor Malignant, | |
Metastatic, Ovary | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|
DAY ON TEST | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|
| 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|
18 MG/M3 | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6| |
DAY ON TEST | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7| |
| 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| A |
18 MG/M3 | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + A + + + + + + + + A + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + A + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + M + + + + + + M + + A + + +| 41 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + A + + + + + + + A + + + + + + + + A + + +| 38 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa-Theca Tumor Malignant, | | |
Metastatic, Ovary | | 1 |
Leukemia Mononuclear | X X X X X X| 13 |
Neoplastic Nodule | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosarcoma | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa-Theca Tumor Malignant, | | |
Metastatic, Ovary | | 1 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granulosa-Theca Tumor Malignant, | | |
Metastatic, Ovary | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6| |
DAY ON TEST | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7| |
| 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| A |
18 MG/M3 | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granulosa-Theca Tumor Malignant, | | |
Metastatic, Ovary | | 1 |
Leukemia Mononuclear | X X| 6 |
Pheochromocytoma Malignant | X X X | 7 |
Pheochromocytoma Benign | X X X X X | 11 |
Bilateral, Pheochromocytoma Malignant| X X | 3 |
Bilateral, Pheochromocytoma Benign | X X X | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X | 3 |
Pars Distalis, Adenoma | X X X X X X X X X X X X| 21 |
Pars Distalis, Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Adenoma | X X X | 6 |
C-Cell, Carcinoma | X| 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + M + + + + + + + + M + + + + + + + + +| 46 |
Adenoma | | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Bilateral, Granulosa-Theca Tumor | | |
Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 2 |
Polyp Stromal | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6| |
DAY ON TEST | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7| |
| 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| A |
18 MG/M3 | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inguinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X X| 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + M M + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X | 6 |
Squamous Cell Carcinoma, Metastatic, | | |
Lung | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Leukemia Mononuclear | X X X X| 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + + + + + + + + + + + + + + + + + + + M + +| 47 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Granulosa-Theca Tumor Malignant, | | |
Metastatic, Ovary | | 1 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X X| 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X| 18 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X | 6 |
Schwannoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | | 2 |
Adenoma | X X | 2 |
Fibroadenoma | X X X X X X X | 13 |
Fibrosarcoma | | 1 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6| |
DAY ON TEST | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7| |
| 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| A |
18 MG/M3 | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + I + I + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X | 8 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | X X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Granulosa-Theca Tumor Malignant, | | |
Metastatic, Ovary | | 1 |
Leukemia Mononuclear | X X X X X | 10 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X| 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1| | |
DAY ON TEST | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9| | |
| 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3| | A |
CONTROL | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + M + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + | 14 |
Bilateral, Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + M + + + + + + + | 14 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + M + M + + + | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
Pars Distalis, Adenoma | X X X X | 4 |
Pars Distalis, Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + M + + + | 13 |
C-Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1| | |
DAY ON TEST | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9| | |
| 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3| | A |
CONTROL | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
Polyp | X | 1 |
Polyp Stromal | X | 1 |
Sarcoma Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + + M M + + + + + M + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M + + M + + + + M + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + M M + M + + M + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 15 |
Adenoma | X X | 2 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Zymbal's Gland | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1| | |
DAY ON TEST | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9| | |
| 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3| | A |
CONTROL | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7| | |
DAY ON TEST | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3| | |
| 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4| | A |
6 MG/M3 | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 18 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + | 16 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + | 18 |
Pheochromocytoma Benign | X X X X | 4 |
Bilateral, Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + I | 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + M + + + + M + | 15 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 18 |
Pars Distalis, Adenoma | X X X X X X X | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + M I | 16 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7| | |
DAY ON TEST | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3| | |
| 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4| | A |
6 MG/M3 | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Granulosa-Theca Tumor Malignant | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + | 18 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 18 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + M + M + + + M + + | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + M + + + + M + + | 15 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + | 18 |
Fibroadenoma | X X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 18 |
Alveolar/Bronchiolar Adenoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7| | |
DAY ON TEST | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3| | |
| 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4| | A |
6 MG/M3 | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + | 18 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1| | |
DAY ON TEST | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9| | |
| 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8| | A |
18 MG/M3 | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M M + + + M + + + M + | 8 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + + + | 11 |
Bilateral, Pheochromocytoma Benign | X X X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M M + + + M | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 12 |
Pars Distalis, Adenoma | X X X X X | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + I + + + + + | 11 |
C-Cell, Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1| | |
DAY ON TEST | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9| | |
| 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8| | A |
18 MG/M3 | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Polyp Stromal | X X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 12 |
Deep Cervical, Carcinoma, Metastatic,| | |
Thyroid Gland | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 12 |
Adenoma | X | 1 |
Fibroadenoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + | 12 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1| | |
DAY ON TEST | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9| | |
| 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8| | A |
18 MG/M3 | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
Urinary Bladder | + + + + + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|
DAY ON TEST | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|
| 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + M + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + A + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
Neoplastic Nodule, Multiple | X X |
Osteosarcoma, Multiple, Metastatic, | |
Bone | |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X X X X X X|
Bilateral, Pheochromocytoma Malignant| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|
DAY ON TEST | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|
| 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, Pheochromocytoma Benign | X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + I + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Benign | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Leukemia Mononuclear | X |
Lumbar, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X X X X |
Renal, Leukemia Mononuclear | X |
Thoracic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|
DAY ON TEST | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|
| 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Lymphocytic | |
Thymoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + M +|
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Scapula, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | |
Hindlimb, Leukemia Mononuclear | |
Sternal, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
Lymphoma Malignant Lymphocytic | |
Osteosarcoma, Multiple, Metastatic, | |
Bone | |
Schwannoma Malignant, Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Chondroma | |
Mucosa, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|
DAY ON TEST | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|
| 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Lymphocytic | |
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X |
Lymphoma Malignant Lymphocytic | |
Mesothelioma Benign | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6| |
DAY ON TEST | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2| |
| 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2| A |
CONTROL | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + A + A + + + + + A A + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + A + A + M + + + A A + +| 42 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + A + + + + + A A + +| 43 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + M + + + + + + M A + A + + + + + A A + M| 38 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + + + + + + + + + A + A + + + + A A A + +| 39 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + + + + + + + A + + A + A + + + + A A A + +| 40 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X | 18 |
Neoplastic Nodule, Multiple | | 2 |
Osteosarcoma, Multiple, Metastatic, | | |
Bone | X| 1 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 4 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6| |
DAY ON TEST | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2| |
| 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2| A |
CONTROL | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 5 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X X X X | 13 |
Bilateral, Pheochromocytoma Malignant| X | 1 |
Bilateral, Pheochromocytoma Benign | X X X X X X X | 12 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
Adenoma | X | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M + + M + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + I + +| 47 |
Leukemia Mononuclear | X X X | 4 |
Pars Distalis, Adenoma | X X X X X X X X X X| 12 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + A A + +| 45 |
C-Cell, Adenoma | X X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Adenoma | X | 1 |
Carcinoma | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 3 |
Mesothelioma Benign | X | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X | 18 |
Interstitial Cell, Adenoma | X X X X X | 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 39
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6| |
DAY ON TEST | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2| |
| 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2| A |
CONTROL | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Iliac, Leukemia Mononuclear | | 1 |
Lumbar, Leukemia Mononuclear | X | 2 |
Pancreatic, Leukemia Mononuclear | X X X X | 10 |
Renal, Leukemia Mononuclear | | 1 |
Thoracic, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + + I M + + M + + M + + + M +| 41 |
Leukemia Mononuclear | X X X X X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M M M + + + + + + + +| 46 |
Leukemia Mononuclear | X X X X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X | 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrosarcoma | X | 1 |
Leukemia Mononuclear | X X X X X X X X X X | 24 |
Osteosarcoma, Metastatic, Bone | X| 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X | 9 |
Lymphoma Malignant Lymphocytic | X | 1 |
Thymoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + M + + + + + + +| 45 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Scapula, Osteosarcoma | X| 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Hindlimb, Leukemia Mononuclear | X | 1 |
Sternal, Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6| |
DAY ON TEST | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2| |
| 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2| A |
CONTROL | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Astrocytoma Malignant | X | 1 |
Leukemia Mononuclear | X X X X | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X | 16 |
Lymphoma Malignant Lymphocytic | X | 1 |
Osteosarcoma, Multiple, Metastatic, | | |
Bone | X| 1 |
Schwannoma Malignant, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Chondroma | X | 1 |
Mucosa, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X | 7 |
Renal Tubule, Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X X X X X X X X | 24 |
Lymphoma Malignant Lymphocytic | X | 1 |
Mesothelioma Benign | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|
| 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|
6 MG/M3 | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + A + + + + + + + + A A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A A + + + + + A A + + + + + + + + A A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + A + + + + + + + + A A|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + A + + + + + M A + + + + + + + + A A|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + A + + + + + + + + A A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + + + + + + + A A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A A + A + + + A A + + + + + + + A A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A A + A + + + A A + + + + + + + + A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
Neoplastic Nodule, Multiple | X |
Hepatocyte, Adenoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + I + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Malignant | X X X|
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + M + M + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A A|
C-Cell, Adenoma | X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|
| 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|
6 MG/M3 | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + M + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + M + M + + + + + + + + + + I + M + + + + + + + M|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|
| 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|
6 MG/M3 | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Keratoacanthoma | X |
Neurofibroma | X |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pelvis, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X |
Osteosarcoma, Metastatic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7| |
DAY ON TEST | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4| |
| 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
6 MG/M3 | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + A + + + A + + + + A + + + A + + A + + +| 38 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + A + + + + + + + + + + + + + + + A + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + A + + + M + + + + + + + + + + + + + + +| 41 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + + A + + A + A + + + A + + A + + A| 34 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + + + + + A + + + + + A + + A + + +| 38 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X | 15 |
Neoplastic Nodule, Multiple | | 1 |
Hepatocyte, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + A + + +| 46 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibroma | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + A + + +| 47 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X | 2 |
Pheochromocytoma Malignant | | 3 |
Pheochromocytoma Complex | X X | 2 |
Pheochromocytoma Benign | X X X X X X X | 9 |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + A + M + M + M + + M + + + + + + A + + +| 41 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + M + + +| 45 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7| |
DAY ON TEST | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4| |
| 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
6 MG/M3 | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X X X X X X| 11 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + A + + +| 46 |
C-Cell, Adenoma | X | 4 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 1 |
Carcinoma | X X X | 6 |
__________________________________________________________________________|____________|
Prostate | M M + + + M + + + + + + + + + + + + A + + + + + +| 45 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X| 24 |
Interstitial Cell, Adenoma | X X X | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X X | 4 |
Renal, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + I + + + + + + + + + + + + I + + +| 48 |
Leukemia Mononuclear | X X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + I + + + + + + A + + +| 48 |
Leukemia Mononuclear | X X X X X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7| |
DAY ON TEST | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4| |
| 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
6 MG/M3 | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Histiocytoma | | 1 |
Leukemia Mononuclear | X X X X X X X X X X X | 21 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + I + + + + + + + + + M + + + M M + M| 40 |
Leukemia Mononuclear | X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibroma | X | 2 |
Keratoacanthoma | X | 2 |
Neurofibroma | | 1 |
Squamous Cell Carcinoma | X| 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pelvis, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X X X X | 9 |
Osteosarcoma, Metastatic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + A + + + + + + + + A + + + + + + + + + +| 48 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7| |
DAY ON TEST | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4| |
| 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
6 MG/M3 | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + M + + + +| 48 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X X X | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|
| 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|
18 MG/M3 | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + A A + + + + + + A + + + + + + + + A + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + M M M + + + + + + M A + + + + M + + + A + M|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + + A A + + + + + + + A + + + + + + + + A + A|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A + + + + + + + A + + + + + + + + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X X X X X X X X X |
Neoplastic Nodule | X |
Neoplastic Nodule, Multiple | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + A + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + A + +|
Fibrosarcoma | X|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + A + +|
Fibrosarcoma | X|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + M + + + + + + + + A + +|
Leukemia Mononuclear | X X X X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
Pheochromocytoma Malignant | X |
Pheochromocytoma Complex | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|
| 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|
18 MG/M3 | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X X X X X X X |
Bilateral, Pheochromocytoma Malignant| |
Bilateral, Pheochromocytoma Benign | X X X X X X X X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M M + + + + + A + + + + + + + + A I +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + I + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
C-Cell, Adenoma | X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + A + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A A +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + A + + + + I + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|
| 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|
18 MG/M3 | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + A + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant | X |
Fibrous Histiocytoma | X |
Keratoacanthoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Leukemia Mononuclear | X X X X X X X X X |
Osteosarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urethra | + |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|
| 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|
18 MG/M3 | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + A + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8| |
DAY ON TEST | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0| |
| 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| A |
18 MG/M3 | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + I + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + A + + + + + A A + + A + + + + + A + A +| 37 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + A + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + M + + M M + + + + M A + + + + + + M + +| 34 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + A M A + + + + + + + + + A + + + + + + A A A| 35 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + + + + + + + + A + + + + + + + A A| 40 |
__________________________________________________________________________|____________|
Liver | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X | 16 |
Neoplastic Nodule | | 1 |
Neoplastic Nodule, Multiple | X X | 3 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrosarcoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrosarcoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8| |
DAY ON TEST | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0| |
| 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| A |
18 MG/M3 | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 4 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
Pheochromocytoma Malignant | X X X X X | 6 |
Pheochromocytoma Complex | X | 1 |
Pheochromocytoma Benign | X X X X X X X X X X X X X | 20 |
Bilateral, Pheochromocytoma Malignant| X | 1 |
Bilateral, Pheochromocytoma Benign | X X X X X| 16 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + M + + + + + + + + + + + + + + + +| 43 |
Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + M + +| 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X | 1 |
Pars Distalis, Adenoma | X X X X | 10 |
Pars Intermedia, Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + A + A + + + + + + + + + + + + + + + + M + +| 46 |
C-Cell, Adenoma | X | 3 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Penis | + | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Adenoma | | 1 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + A + A + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | X | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X| 24 |
Interstitial Cell, Adenoma | X X X X X | 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8| |
DAY ON TEST | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0| |
| 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| A |
18 MG/M3 | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + I + + + + + + + + + + + + I + + + + + + + + + +| 47 |
Leukemia Mononuclear | X X X | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + A + + + + + A + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | X | 11 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | X X X X X X X X X | 22 |
__________________________________________________________________________|____________|
Thymus | M I + A + + + + + + + + M + + + + M + + M + + + M| 43 |
Leukemia Mononuclear | | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basosquamous Tumor Malignant | | 1 |
Fibrous Histiocytoma | | 1 |
Keratoacanthoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8| |
DAY ON TEST | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0| |
| 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| A |
18 MG/M3 | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Multiple | | 1 |
Leukemia Mononuclear | X X X X | 13 |
Osteosarcoma, Metastatic, Uncertain | | |
Primary Site | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + A + + + + + + + + + + + + + + + + + A A + +| 47 |
__________________________________________________________________________|____________|
Trachea | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Mononuclear | X X X X X X X X X | 23 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7| | |
DAY ON TEST | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3| | |
| 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1| | A |
CONTROL | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + + | 10 |
Pheochromocytoma NOS | X | 1 |
Bilateral, Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A M | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + M + M M | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + | 11 |
Pars Distalis, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 11 |
C-Cell, Adenoma | X | 1 |
Follicle, Adenocarcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + M + + + + M | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7| | |
DAY ON TEST | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3| | |
| 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1| | A |
CONTROL | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + M | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + | 11 |
Bilateral, Interstitial Cell, Adenoma| X X X | 3 |
Interstitial Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Zymbal's Gland | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7| | |
DAY ON TEST | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3| | |
| 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1| | A |
CONTROL | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
Urinary Bladder | + + + + + + + + + + + | 11 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7| | |
DAY ON TEST | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3| | |
| 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3| | A |
6 MG/M3 | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + M M M M + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 15 |
Pheochromocytoma Benign | X X | 2 |
Bilateral, Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M + + + + + + M M M + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + | 14 |
Pars Distalis, Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + M + | 13 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7| | |
DAY ON TEST | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3| | |
| 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3| | A |
6 MG/M3 | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Bilateral, Interstitial Cell, Adenoma| X X X | 3 |
Interstitial Cell, Adenoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + M + + M + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + M + + + + + + M M + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + M + + + + | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + M + + + + + + + + + M | 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Zymbal's Gland | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7| | |
DAY ON TEST | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3| | |
| 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3| | A |
6 MG/M3 | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Cortex, Hamartoma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 15 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 5| 3| 7| 1| 7| 3| 6| 5| 5| 6| 1| 6| 1| 7| 7| 7| 5| 6| 7| | |
DAY ON TEST | 5| 3| 3| 5| 3| 0| 9| 2| 3| 2| 6| 1| 2| 9| 5| 9| 3| 3| 3| 5| 5| 1| | |
| 7| 1| 3| 6| 3| 4| 2| 4| 3| 7| 8| 0| 9| 3| 1| 4| 0| 8| 8| 6| 1| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 4| 5| 5| 7| 7| 7| 7| 9| 0| 0| 1| 2| 2| 4| 4| 4| 5| 6| 6| 7| 7| | A |
18 MG/M3 | 7| 8| 3| 4| 0| 1| 3| 9| 9| 0| 4| 8| 1| 3| 1| 8| 9| 0| 5| 9| 2| 3| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
Pheochromocytoma Benign | X | 1 |
Bilateral, Pheochromocytoma Benign | X X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Pars Distalis, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M M + + | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + I + I + + + + + | 8 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 05079-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TALC Date: 04/07/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:47:25
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 5| 3| 7| 1| 7| 3| 6| 5| 5| 6| 1| 6| 1| 7| 7| 7| 5| 6| 7| | |
DAY ON TEST | 5| 3| 3| 5| 3| 0| 9| 2| 3| 2| 6| 1| 2| 9| 5| 9| 3| 3| 3| 5| 5| 1| | |
| 7| 1| 3| 6| 3| 4| 2| 4| 3| 7| 8| 0| 9| 3| 1| 4| 0| 8| 8| 6| 1| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 4| 5| 5| 7| 7| 7| 7| 9| 0| 0| 1| 2| 2| 4| 4| 4| 5| 6| 6| 7| 7| | A |
18 MG/M3 | 7| 8| 3| 4| 0| 1| 3| 9| 9| 0| 4| 8| 1| 3| 1| 8| 9| 0| 5| 9| 2| 3| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Bilateral, Interstitial Cell, Adenoma| X | 1 |
Interstitial Cell, Adenoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + | 9 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
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---------- END OF REPORT ----------
------------------------------------------------------------