TDMS Study 05079-01 Pathology Tables
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 14807966
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|
DAY ON TEST | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|
| 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + A + + + + + + + + + + + + + + A|
Inflammation | 2 2 3 1 1 |
Parasite Metazoan | X X X X X |
Ulcer | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | M M + + + + + + + + + + + + + + + + M + + + + M +|
Inflammation | 2 1 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 3 3 1 1 2 2 2 2 2 3 1|
Clear Cell Focus | 2 |
Cyst Multilocular | X |
Eosinophilic Focus | 1|
Fatty Change | 1 2 3 3 2 4 2|
Hematopoietic Cell Proliferation | 1 |
Inflammation, Focal, Granulomatous | 1 1 1 2 1 2 1 3 |
Inflammation, Suppurative | |
Necrosis, Focal | 1 |
Pigmentation, Hemosiderin | 3 |
Bile Duct, Hyperplasia | 1 4 1 1 4 1 1 2 1 2 1 1 2 1 2 1 2 2 2 |
Centrilobular, Degeneration | 4 4 4 4 3 4 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | |
Granuloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 3 |
Lobules, Atrophy | 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation | |
Ulcer | 4 3 2 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|
DAY ON TEST | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|
| 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation | 3 |
Mineralization | 2 3 |
Ulcer | 3 3 |
Ulcer, Multiple | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Mesenteric Artery, Aneurysm | |
Mesenteric Artery, Inflammation | 3 3 |
Mesenteric Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 1 2 1 2 2 2 1 1 2 2 2 2 2 2 2 |
Inflammation, Focal | 2 |
Atrium, Thrombosis | X X X X |
Myocardium, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Degeneration, Fatty | 3 |
Degeneration, Focal | |
Hyperplasia, Focal | 3 1 2 2 3 |
Necrosis, Focal | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + I + + + + + + + M + + +|
Cyst | |
Hyperplasia | 2 2 3 2 2 2 4 3 1 2 3 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Pars Distalis, Hyperplasia | 2 3 2 3 2 2 3 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 4 3 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|
DAY ON TEST | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|
| 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 |
Inflammation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation | 2 |
Endometrium, Hyperplasia | 4 3 |
Lamina Propria, Fibrosis | 2 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia, Histiocytic | 4 |
Inflammation, Focal, Granulomatous | |
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + + + + + M + + + +|
Cyst | 4 |
Inflammation, Suppurative | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + M + + + + + + + + +|
Hemorrhage, Chronic | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 |
Inflammation, Chronic Active | 2 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Fibrosis, Focal | 3 4 4 |
Hematopoietic Cell Proliferation | 3 3 3 |
Inflammation, Focal, Granulomatous | 2 |
Pigmentation, Hemosiderin | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|
DAY ON TEST | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|
| 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X |
Hyperostosis | X X X |
Pelvis, Fracture | |
Vertebra, Cyst | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Crystals, Focal | |
Edema | |
Inflammation, Granulomatous | 2 1 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 1 |
Bronchus, Epithelium, Degeneration, | |
Focal | |
Interstitium, Fibrosis, Focal | 1 |
__________________________________________________________________________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Nerve, Developmental Malformation | |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 3 |
Retina, Degeneration | 4 3 |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation | 2 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|
DAY ON TEST | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|
| 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Abscess | 2 |
Cyst, Multiple | |
Infarct | 3 |
Inflammation | 2 |
Nephropathy | 4 3 1 1 2 4 2 1 3 3 4 3 4 4 1 2 2 3 2 1 2 2|
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5| |
DAY ON TEST | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8| |
| 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
CONTROL | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +| 46 |
Inflammation | 2 2 2 1 3 2 | 11 1.9|
Parasite Metazoan | X X | 7 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + M + + M + + + + + M M + + + M + + + A A| 38 |
Inflammation | 1 3 | 4 1.8|
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + A + + + + A + + + + + + + + A +| 44 |
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + A A +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 3 1 3 1 4 1 4 3 1 1 2 2 2| 27 2.1|
Clear Cell Focus | | 1 2.0|
Cyst Multilocular | | 1 |
Eosinophilic Focus | 1 | 2 1.0|
Fatty Change | 1 4 3 3 3 1 3 2 2 4 2| 18 2.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Focal, Granulomatous | 2 2 1 3 1 | 13 1.6|
Inflammation, Suppurative | 3 | 1 3.0|
Necrosis, Focal | 1 2 2 1 | 5 1.4|
Pigmentation, Hemosiderin | | 1 3.0|
Bile Duct, Hyperplasia | 2 2 2 2 1 1 1 1 1 1 3 2 1 2 3 1 1| 36 1.6|
Centrilobular, Degeneration | 2 4 3 2 | 10 3.4|
Centrilobular, Necrosis | 1 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Granuloma | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Nodular | | 1 3.0|
Lobules, Atrophy | 1 1 1 2 | 7 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 2 2.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5| |
DAY ON TEST | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8| |
| 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
CONTROL | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | | 1 3.0|
Inflammation | 1 | 1 1.0|
Ulcer | 3 3 3 3 | 9 3.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 3.0|
Mineralization | | 2 2.5|
Ulcer | 3 | 3 3.0|
Ulcer, Multiple | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
Mesenteric Artery, Aneurysm | X | 1 |
Mesenteric Artery, Inflammation | 3 | 3 3.0|
Mesenteric Artery, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 1 1 1 2 2 1 1 1 2 2 1 1 4 1 2 1 | 35 1.6|
Inflammation, Focal | | 1 2.0|
Atrium, Thrombosis | X | 5 |
Myocardium, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 2.0|
Degeneration, Fatty | 4 2| 3 3.0|
Degeneration, Focal | 1 | 1 1.0|
Hyperplasia, Focal | 3 2 2 2 | 9 2.2|
Necrosis, Focal | 2 | 1 2.0|
Pigmentation, Hemosiderin | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | 2 | 1 2.0|
Hyperplasia | 1 4 1 3 4 3 2 1 2| 20 2.4|
Bilateral, Hyperplasia | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + M + M + + + + + + M + M + + + + + + M +| 43 |
Hyperplasia | 2 | 3 2.3|
Bilateral, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5| |
DAY ON TEST | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8| |
| 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
CONTROL | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | | 2 |
Pars Distalis, Hyperplasia | 1 2 | 10 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 2 2 | 10 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
Hyperplasia | 4 | 2 3.0|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X 3 X | 5 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Inflammation | | 1 2.0|
Endometrium, Hyperplasia | 1 | 3 2.7|
Lamina Propria, Fibrosis | 1 1 2 1 1 1 2 2 2 1 1 2 1| 20 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Hyperplasia, Histiocytic | | 1 4.0|
Inflammation, Focal, Granulomatous | 2 | 1 2.0|
Myelofibrosis | | 1 2.0|
Myeloid Cell, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + + + + + + M + + + + + + + + + + + +| 46 |
Cyst | | 1 4.0|
Inflammation, Suppurative | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + M + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Plasma Cell | 3 | 2 2.5|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Hemorrhage, Chronic | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5| |
DAY ON TEST | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8| |
| 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
CONTROL | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
Inflammation, Chronic Active | 2 | 4 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 2 3.0|
Fibrosis, Focal | | 3 3.7|
Hematopoietic Cell Proliferation | 3| 4 3.0|
Inflammation, Focal, Granulomatous | | 1 2.0|
Pigmentation, Hemosiderin | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + M +| 47 |
Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | X X | 4 |
Hyperostosis | X | 4 |
Pelvis, Fracture | X | 1 |
Vertebra, Cyst | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Crystals, Focal | 3 | 1 3.0|
Edema | 3 | 1 3.0|
Inflammation, Granulomatous | | 2 1.5|
Inflammation, Suppurative | 4 3 | 2 3.5|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5| |
DAY ON TEST | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8| |
| 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
CONTROL | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Bronchus, Epithelium, Degeneration, | | |
Focal | 3 | 1 3.0|
Interstitium, Fibrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Nerve, Developmental Malformation | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 3.0|
Retina, Degeneration | | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 5 |
Inflammation | 4 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | | 1 2.0|
Cyst, Multiple | X | 1 |
Infarct | | 1 3.0|
Inflammation | | 1 2.0|
Nephropathy | 1 3 1 4 2 1 3 1 2 4 4 4 1 3 2 3 3 3 2 3 3 1| 44 2.5|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|
DAY ON TEST | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|
| 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|
6 MG/M3 | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + A + + + + + + + + A + + + + A + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + A + + A A + + + + A + A + + A + + +|
Hemorrhage, Focal | |
Inflammation | |
Parasite Metazoan | X X |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + A + + A A + + + + A + + + + A + + +|
Inflammation | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + M + + + M + M M + A + + + + M + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + A + + + + A + + A A + + + + A + + + + A A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + A + + A A + + + + A + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +|
Atrophy | |
Basophilic Focus | 3 1 2 1 2 4 2 |
Clear Cell Focus | 1 |
Degeneration, Cystic | 3 1 |
Eosinophilic Focus | 2 |
Fatty Change | 4 4 1 4 4 3 4 |
Inflammation, Focal, Granulomatous | 2 2 |
Inflammation, Focal, Necrotizing | 3 |
Necrosis, Focal | 3 |
Bile Duct, Hyperplasia | 2 1 1 1 1 2 1 2 1 3 3 2 1 2 4 3 1|
Centrilobular, Atrophy | 2 |
Centrilobular, Degeneration | 4 3 4 3 4 4|
Centrilobular, Necrosis | 3 4 |
Serosa, Thrombosis | X X X |
__________________________________________________________________________|
Mesentery | + + |
Granuloma | 3 |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + M + + + + + + + + A + + + + + + + +|
Inflammation | |
Lobules, Atrophy | 1 4 4 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + M + + + + + + + + + + A M + + + + + + +|
Mineralization | |
Ulcer | 2 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|
DAY ON TEST | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|
| 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|
6 MG/M3 | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 4 |
Ulcer | 3 |
Arteriole, Muscularis, Lamina | |
Propria, Mineralization | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 4 |
Mesenteric Artery, Mineralization | 4 |
Mesenteric Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + A + + + + + + + +|
Cardiomyopathy | 2 3 1 2 1 1 2 2 2 2 1 1 2 1 1 1 1 1 1 1|
Atrium, Thrombosis | X X X X X X |
Myocardium, Embolus | 2 |
Myocardium, Inflammation, Focal | 3 |
Myocardium, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +|
Degeneration, Focal | |
Hyperplasia, Diffuse | 1 |
Hyperplasia, Focal | 3 2 2 2 3 |
Necrosis, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 1 1 1 1 2 2 2 4 1 2|
Bilateral, Hyperplasia | 4 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M + + + + + + + + A + M + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + A + + + + I + + +|
Hyperplasia | 4 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
Pars Distalis, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + A + + + + + A + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + M + + + + + A + M + + + + + +|
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|
DAY ON TEST | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|
| 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|
6 MG/M3 | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation | 4 |
Lamina Propria, Fibrosis | 1 2 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + A + + +|
Atrophy | 3 3 |
Myelofibrosis | 2 |
Necrosis, Focal | |
Myeloid Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + A + + + + + + + +|
Fibrosis | |
Hemorrhage, Chronic | 2 |
Hyperplasia, Histiocytic | 2 1 1 2 2 2 2 2 2 4 2 2 3 2 2 2 2 2 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + M + + A M + + + + + + +|
Hyperplasia, Histiocytic | 3 2 2 3 2 2 2 3 2 2 3 2 3 2 1 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Atrophy | 3 2|
Fibrosis, Focal | 4 |
Hematopoietic Cell Proliferation | 4 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Hyperplasia, Cystic | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + A + + + + + + + +|
Fibrous Osteodystrophy | X |
Hyperostosis | X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|
DAY ON TEST | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|
| 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|
6 MG/M3 | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + A + + + + + + + +|
Compression | 3 X 4 4 X |
Hemorrhage | |
Inflammation, Focal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + A + + + + + + + +|
Cyst | X |
Hemorrhage | |
Inflammation, Granulomatous | 2 2 2 1 2 2 1 2 1 2 1 1 2 1 1 2 2 2 2 1 1 2 1|
Inflammation, Suppurative | |
Mineralization | 3 |
Alveolar Epithelium, Hyperplasia | 1 2 1 2 1 1 1 1 1 2 1 2 1 1 1 1|
Interstitium, Fibrosis, Focal | 1 1 2 4 1 4 1 1 1|
Interstitium, Mineralization | |
Peribronchial, Hyperplasia, | |
Histiocytic | 1 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Suppurative | 4 |
Mucosa, Inflammation, Suppurative | 3 3 |
Olfactory Epithelium, Metaplasia | 4 |
Respiratory Epithelium, Hyperplasia | 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + A + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +|
Cyst | |
Embolus, Multiple | |
Inflammation | 3 |
Nephropathy | 3 3 1 3 3 2 2 3 2 4 3 1 1 3 2 4 4 3 2 1 1 4|
Capsule, Inflammation | 3 |
Medulla, Inflammation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8| |
| 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| A |
6 MG/M3 | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + A + + + A + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + A + A + A + A + + + + + A + + A A| 34 |
Hemorrhage, Focal | 3 | 1 3.0|
Inflammation | 3 | 1 3.0|
Parasite Metazoan | X | 3 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + A + + + + + + + + + +| 41 |
Inflammation | | 1 2.0|
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + M + M + A + + + A + M + + + + + + + +| 37 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + A + A + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + A + + + A M + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + A A A + + + A + A + + + A + + A A| 32 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + A + + + A + + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 | 1 2.0|
Basophilic Focus | 3 2 1 3 2 1 1 1 1 2| 17 1.9|
Clear Cell Focus | 1 | 2 1.0|
Degeneration, Cystic | | 2 2.0|
Eosinophilic Focus | 2 3 1 1 | 5 1.8|
Fatty Change | 4 4 4 1 4 1 3 1 2 3 3 | 18 3.0|
Inflammation, Focal, Granulomatous | 2 | 3 2.0|
Inflammation, Focal, Necrotizing | | 1 3.0|
Necrosis, Focal | | 1 3.0|
Bile Duct, Hyperplasia | 1 1 1 1 2 1 3 3 1 1 1 2 3 2 1 1 2 2 3 4 2| 38 1.8|
Centrilobular, Atrophy | 3 | 2 2.5|
Centrilobular, Degeneration | 4 4 4 4 3 4 4 4 | 14 3.8|
Centrilobular, Necrosis | | 2 3.5|
Serosa, Thrombosis | | 3 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Granuloma | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + +| 46 |
Inflammation | 3 | 1 3.0|
Lobules, Atrophy | 3 1 1 | 7 2.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8| |
| 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| A |
6 MG/M3 | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + +| 45 |
Mineralization | 3 | 1 3.0|
Ulcer | 1 4| 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Inflammation | 2 | 1 2.0|
Mineralization | 3 | 2 3.5|
Ulcer | 1 | 2 2.0|
Arteriole, Muscularis, Lamina | | |
Propria, Mineralization | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tongue | + | 2 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 3 |
Aorta, Mineralization | 3 4 | 3 3.7|
Mesenteric Artery, Mineralization | | 1 4.0|
Mesenteric Artery, Thrombosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cardiomyopathy | 1 1 1 1 1 2 4 2 2 2 1 1 2 1 1 1 1 1 1 1| 40 1.4|
Atrium, Thrombosis | 4 X | 8 4.0|
Myocardium, Embolus | 3 | 2 2.5|
Myocardium, Inflammation, Focal | | 1 3.0|
Myocardium, Mineralization | 4 4 1 | 4 3.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Degeneration, Focal | 4 | 1 4.0|
Hyperplasia, Diffuse | | 1 1.0|
Hyperplasia, Focal | 4 2 2 2 2 3 1 | 12 2.3|
Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Hyperplasia | 4 2 3 1 4 3 1 1 | 18 2.0|
Bilateral, Hyperplasia | | 2 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + M + + + I + + M +| 42 |
Hyperplasia | 4 2 | 4 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + I + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 1 2 1 | 6 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8| |
| 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| A |
6 MG/M3 | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
C-Cell, Hyperplasia | 2 3 1 | 8 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + +| 44 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + M + + + + + +| 47 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Cyst | | 1 |
Inflammation | | 1 4.0|
Lamina Propria, Fibrosis | 1 1 1 1 2 1 1 1 2 1 2 1 1 1 2 2 2 1 1| 39 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A A + + A + + + + + + + + + + + + A +| 43 |
Atrophy | | 2 3.0|
Myelofibrosis | 3 1 | 3 2.0|
Necrosis, Focal | 4 | 1 4.0|
Myeloid Cell, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Fibrosis | 4 | 1 4.0|
Hemorrhage, Chronic | | 1 2.0|
Hyperplasia, Histiocytic | 3 2 2 2 2 2 1 2 3 3 2 1 2 3 2 2 2 2 2 2 1| 40 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + A + + + + + + + + M + + + + +| 46 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + M + + + + + + + + +| 44 |
Hyperplasia, Histiocytic | 3 2 2 2 2 1 2 2 3 3 4 2 2 3 2 3 2 2| 33 2.3|
Inflammation, Suppurative | 3| 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 2 2.5|
Fibrosis, Focal | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8| |
| 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| A |
6 MG/M3 | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 2 3 2 | 6 2.8|
__________________________________________________________________________|____________|
Thymus | + + + I M M + + + + + + + + + + + + + + + + + +| 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Galactocele | | 1 |
Hyperplasia, Cystic | 3 | 2 3.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Fibrous Osteodystrophy | X 3 | 3 3.0|
Hyperostosis | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Compression | X X | 7 3.7|
Hemorrhage | 3 | 1 3.0|
Inflammation, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Granulomatous | 2 1 2 1 2 1 1 1 2 2 2 2 2 1 2 1 2 1 1 1 1 1 2 2| 47 1.5|
Inflammation, Suppurative | 2 | 1 2.0|
Mineralization | 4 | 2 3.5|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 2 | 27 1.2|
Interstitium, Fibrosis, Focal | 1 1 1 1 1 1 1 1 2 1 1 1 1 4 1| 24 1.5|
Interstitium, Mineralization | 3 | 1 3.0|
Peribronchial, Hyperplasia, | | |
Histiocytic | 1 1 2 1| 8 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + A + A + + + + + + + + + +| 45 |
Inflammation, Suppurative | | 1 4.0|
Mucosa, Inflammation, Suppurative | 4 | 3 3.3|
Olfactory Epithelium, Metaplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7| |
DAY ON TEST | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8| |
| 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4| A |
6 MG/M3 | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Hyperplasia | | 1 1.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + + + | 7 |
Inflammation | 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + +| 47 |
Cyst | 3 | 1 3.0|
Embolus, Multiple | 3 | 1 3.0|
Inflammation | | 1 3.0|
Nephropathy | 3 4 4 3 4 2 1 1 3 2 2 1 1 3 4 1 3 2 3 3 4| 43 2.5|
Capsule, Inflammation | | 1 3.0|
Medulla, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + + + M M + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|
DAY ON TEST | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|
| 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|
18 MG/M3 | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + A + + M + + + + A|
Inflammation | |
Parasite Metazoan | X X X X |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + A|
Inflammation | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + M + M M A|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + A + + + A + A A + + + A + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + A + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Basophilic Focus | 1 4 1 3 1 1 2 1 2 2 3 |
Clear Cell Focus | |
Degeneration, Cystic | 2 |
Eosinophilic Focus | 1 1 1 |
Fatty Change | 1 2 3 2 2 1 3 1 3 3 3|
Infiltration Cellular, Mononuclear | |
Cell | |
Inflammation, Focal, Granulomatous | 2 1 |
Necrosis, Focal | 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 1 1 1 1 2 2 1 1 3 1 3 1 2 4 1 2 2 |
Centrilobular, Atrophy | 3 2 2 1 3 |
Centrilobular, Degeneration | 4 4 3 4 4|
Centrilobular, Necrosis | 3 1 |
Hepatocyte, Atrophy, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Lobules, Atrophy | 1 2 1 3 1 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
Hyperkeratosis | |
Inflammation | |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|
DAY ON TEST | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|
| 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|
18 MG/M3 | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
Ulcer, Multiple | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
Mesenteric Artery, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 1 2 1 2 1 1 1 1 3 1 1|
Inflammation, Focal | 4 |
Atrium, Thrombosis | X |
Myocardium, Mineralization | 1 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 2 2 2 3 |
Necrosis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia | 4 2 3 1 4 2 2 |
Bilateral, Hyperplasia | 2 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 2 3 3 |
Pars Distalis, Necrosis | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
C-Cell, Hyperplasia | 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Lamina Propria, Fibrosis | 1 2 2 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|
DAY ON TEST | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|
| 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|
18 MG/M3 | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A|
Atrophy | |
Hyperplasia, Histiocytic | |
Myelofibrosis | 3 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hemorrhage, Chronic | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 4 2 4 3 4 4 4 2 2 3 4 2 2 2 3 2 3 4 3 2 3 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 4 2 3 4 4 3 2 4 3 1 2 1 2 2 2 2 3 2 2 2 2|
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + A|
Hyperplasia, Lymphoid | 3 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 3 3 3 2 3 |
Hyperplasia, Lymphoid | |
Capsule, Hemorrhage | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lobules, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X |
Hyperostosis | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X X |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|
DAY ON TEST | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|
| 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|
18 MG/M3 | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Hemorrhage | |
Hydrocephalus | |
White Matter, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Cyst, Multiple | X X |
Hemorrhage | |
Hyperplasia, Diffuse, Adenomatous | 1 |
Inflammation, Granulomatous | 4 3 4 4 3 3 3 3 3 2 4 2 3 2 4 3 2 2 3 2 1 3 3 3 3|
Alveolar Epithelium, Hyperplasia | 3 1 2 1 3 2 3 2 2 3 1 1 1 2 3 2 2 2 2 3 3 4 1|
Alveolus, Metaplasia, Squamous | 1 1 1 1 1 |
Interstitium, Fibrosis, Focal | 3 1 1 4 1 3 2 3 2 2 3 2 1 2 2 2 3 2 2 3 4 2 1 1|
Interstitium, Fibrosis | |
Interstitium, Mineralization | 3 |
Peribronchial, Hyperplasia, | |
Histiocytic | 2 2 1 |
__________________________________________________________________________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | |
Mucosa, Inflammation, Suppurative | 3 3 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + |
Inflammation | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cyst | |
Infarct, Multiple | 4 |
Nephropathy | 1 4 1 4 3 1 2 3 2 2 3 2 2 4 3 1 4 3 1 2 1 2 |
Medulla, Inflammation | |
Renal Tubule, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|
DAY ON TEST | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|
| 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|
18 MG/M3 | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6| |
DAY ON TEST | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7| |
| 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| A |
18 MG/M3 | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + + + + + + + + + + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + A + + + + + + + + A + + +| 43 |
Inflammation | 2 1 3 2 1 2| 6 1.8|
Parasite Metazoan | X X | 6 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + A + + + + + A + + +| 45 |
Inflammation | 2 2 | 2 2.0|
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + M + + + + + + M + + A + + +| 41 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + A + + + + + + + A + + + + + + + + A + + +| 38 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Basophilic Focus | 1 1 1 1 3 2 2 2 1 1 | 21 1.7|
Clear Cell Focus | 1 | 1 1.0|
Degeneration, Cystic | | 1 2.0|
Eosinophilic Focus | 2 | 4 1.3|
Fatty Change | 1 3 2 | 14 2.1|
Infiltration Cellular, Mononuclear | | |
Cell | 4 | 1 4.0|
Inflammation, Focal, Granulomatous | 1 2 | 4 1.5|
Necrosis, Focal | 3 | 2 2.5|
Thrombosis | X | 1 |
Bile Duct, Hyperplasia | 2 1 2 2 1 1 3 3 1 1 1 1 1 2 2 1 3 3 4| 36 1.8|
Centrilobular, Atrophy | 2 | 6 2.2|
Centrilobular, Degeneration | 2 1 4 4 3| 10 3.3|
Centrilobular, Necrosis | | 2 2.0|
Hepatocyte, Atrophy, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lobules, Atrophy | 3 1 1 | 9 1.7|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6| |
DAY ON TEST | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7| |
| 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| A |
18 MG/M3 | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation | 3 3 | 2 3.0|
Ulcer | 3 | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 4.0|
Mineralization | 3 | 2 2.5|
Ulcer | 3 3 | 3 3.0|
Ulcer, Multiple | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 3.0|
Mesenteric Artery, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 1 1 1 1 1 1 2 1 2 1 2 2 2 1 1| 36 1.4|
Inflammation, Focal | | 1 4.0|
Atrium, Thrombosis | X X X X | 5 |
Myocardium, Mineralization | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Diffuse | 3 | 1 3.0|
Hyperplasia, Focal | 2 2 3 3 2 3 4 2 1 | 13 2.4|
Necrosis | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 3 2 4 1 2 2 | 14 2.5|
Bilateral, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 1 3.0|
Pars Distalis, Hyperplasia | 2 | 4 2.5|
Pars Distalis, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 1 | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6| |
DAY ON TEST | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7| |
| 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| A |
18 MG/M3 | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + + + M + + + + + + + + M + + + + + + + + +| 46 |
Hyperplasia | 4 | 1 4.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Lamina Propria, Fibrosis | 1 1 2 2 1 1 1 2 1 1 2 | 19 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Hyperplasia, Histiocytic | 4 | 1 4.0|
Myelofibrosis | 3 | 3 2.7|
Myeloid Cell, Hyperplasia | 3 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hemorrhage, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + M M + + + + + + + + + + + + +| 47 |
Hyperplasia, Histiocytic | 3 3 3 3 3 4 3 3 3 3 3 3 3 4 3 1 3 3 3 3 2 2| 45 2.9|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + + + + + + + + + + + + + + + + + + + M + +| 47 |
Hyperplasia, Histiocytic | 2 2 2 2 3 2 3 3 4 3 2 4 2 2 3 3 3 2 | 40 2.5|
Hyperplasia, Lymphoid | 3| 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 | 2 3.0|
Fibrosis, Focal | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 | 7 2.9|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Capsule, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6| |
DAY ON TEST | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7| |
| 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| A |
18 MG/M3 | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lobules, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | X X X | 4 |
Hyperostosis | X | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X X X X X X | 9 |
Hemorrhage | 3 | 1 3.0|
Hydrocephalus | 3 | 1 3.0|
White Matter, Necrosis, Focal | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + I + I + + +| 48 |
Inflammation, Necrotizing | | 1 3.0|
Inflammation, Suppurative | 3| 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 5 |
Cyst, Multiple | | 2 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Diffuse, Adenomatous | 2 | 2 1.5|
Inflammation, Granulomatous | 2 2 4 3 2 3 3 3 2 2 3 3 2 4 4 3 4 3 2 2 2 3 2 3 3| 50 2.8|
Alveolar Epithelium, Hyperplasia | 2 2 3 2 1 2 2 2 1 2 2 3 1 3 3 3 2 3 2 2 1 3 3 2| 47 2.1|
Alveolus, Metaplasia, Squamous | 2 1 1 | 8 1.1|
Interstitium, Fibrosis, Focal | 3 3 3 1 2 1 1 2 1 2 4 1 2 3 1 3 2 2 3 1| 45 2.1|
Interstitium, Fibrosis | 3 | 1 3.0|
Interstitium, Mineralization | | 1 3.0|
Peribronchial, Hyperplasia, | | |
Histiocytic | 1 2 1 1 1 1 | 9 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
Lumen, Foreign Body | 1 | 1 1.0|
Mucosa, Inflammation, Suppurative | 2 4 2 | 5 2.8|
Respiratory Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6| |
DAY ON TEST | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7| |
| 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| A |
18 MG/M3 | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Necrotizing | | 1 3.0|
Inflammation, Suppurative | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 4 | 2 3.5|
Retina, Degeneration | 4 | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + +| 15 |
Inflammation | 2 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Infarct, Multiple | | 1 4.0|
Nephropathy | 1 2 3 4 3 4 1 2 1 1 2 4 3 4 3 1 1 2 2 1 | 42 2.3|
Medulla, Inflammation | 4 | 1 4.0|
Renal Tubule, Necrosis | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3| 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1| | |
DAY ON TEST | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9| | |
| 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3| | A |
CONTROL | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + M + + + + + | 13 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
Parasite Metazoan | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Basophilic Focus | 1 1 | 2 1.0|
Eosinophilic Focus | 2 1 | 2 1.5|
Fatty Change | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 | 7 1.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
Lobules, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
Cardiomyopathy | 1 2 1 2 2 1 | 6 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 14 |
Congestion | 4 | 1 4.0|
Degeneration, Cystic | 3 | 1 3.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + | 14 |
Hyperplasia | 3 2 1 | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + M + + + + + + + | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1| | |
DAY ON TEST | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9| | |
| 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3| | A |
CONTROL | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + M + M + + + | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + + M + + + | 13 |
C-Cell, Hyperplasia | 1 2 1 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 15 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
Hyperplasia, Histiocytic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + + M M + + + + + M + | 10 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M + + M + + + + M + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + M M + M + + M + | 11 |
Congestion | 2 1 | 2 1.5|
Pigmentation, Hemosiderin | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 14 |
Hyperplasia, Histiocytic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 15 |
Hyperplasia, Cystic | 2 3 | 2 2.5|
Lobules, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
Femur, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1| | |
DAY ON TEST | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9| | |
| 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3| | A |
CONTROL | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
Compression | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Inflammation, Chronic Active | 2 | 1 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Zymbal's Gland | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 3 2 2 2 1 2 1 1 2 | 9 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7| | |
DAY ON TEST | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3| | |
| 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4| | A |
6 MG/M3 | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + M + + + + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 18 |
Parasite Metazoan | 2 2 1 1 X 1 | 6 1.4|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 18 |
Basophilic Focus | 1 1 1 1 | 4 1.0|
Fatty Change | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + | 18 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 17 |
Hyperplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 17 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + | 18 |
Cardiomyopathy | 2 2 2 3 1 1 2 2 | 8 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + | 16 |
Congestion | 2 | 1 2.0|
Degeneration, Fatty | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + | 18 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + I | 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + + M + + + + M + | 15 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7| | |
DAY ON TEST | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3| | |
| 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4| | A |
6 MG/M3 | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + | 18 |
C-Cell, Hyperplasia | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + M I | 16 |
Fibrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + | 18 |
Hyperplasia, Cystic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 18 |
Hyperplasia, Histiocytic | 2 2 | 2 2.0|
Femoral, Hyperplasia, Histiocytic | 2 | 1 2.0|
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 18 |
Renal, Hyperplasia, Histiocytic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + | 18 |
Hyperplasia, Histiocytic | 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 | 18 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + M + M + + + M + + | 14 |
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + | 17 |
Congestion | 2 | 1 2.0|
Hyperplasia, Histiocytic | 1 2 2 2 2 2 1 2 2 2 2 2 2 2 | 14 1.9|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + | 18 |
Edema | 3 | 1 3.0|
Hyperplasia, Histiocytic | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 18 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + M + + + + M + + | 15 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7| | |
DAY ON TEST | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3| | |
| 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4| | A |
6 MG/M3 | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 18 |
Inflammation, Granulomatous | 1 1 1 1 2 1 2 1 2 1 2 2 1 2 1 2 2 2 | 18 1.5|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 2 2 1 1 2 1 1 1 1 1 2 | 16 1.3|
Interstitium, Fibrosis, Focal | 1 1 1 1 2 1 1 2 2 1 1 1 2 | 13 1.3|
Peribronchial, Hyperplasia, | | |
Histiocytic | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + | 18 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + | 18 |
Nephropathy | 1 2 2 2 3 1 2 3 2 1 3 3 | 12 2.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1| | |
DAY ON TEST | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9| | |
| 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8| | A |
18 MG/M3 | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M M + + + M + + + M + | 8 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + | 12 |
Parasite Metazoan | 3 1 1 2 | 4 1.8|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 12 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 12 |
Basophilic Focus | 2 2 | 2 2.0|
Fibrosis, Focal | 2 | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Bile Duct, Hyperplasia | 1 1 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 12 |
Cardiomyopathy | 2 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + + + + + | 11 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + M M + + + M | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 12 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + I + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1| | |
DAY ON TEST | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9| | |
| 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8| | A |
18 MG/M3 | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 12 |
Hyperplasia, Histiocytic | 2 2 | 2 2.0|
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + + + | 9 |
Hyperplasia, Histiocytic | 3 3 3 2 3 3 4 2 | 8 2.9|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + | 11 |
Congestion | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + | 12 |
Congestion | 2 | 1 2.0|
Hyperplasia, Histiocytic | 2 3 3 2 3 2 3 3 4 | 9 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 12 |
Inflammation, Granulomatous | 3 2 2 3 3 1 2 3 2 2 2 3 | 12 2.3|
Alveolar Epithelium, Hyperplasia | 1 1 1 2 2 2 2 2 3 3 | 10 1.9|
Interstitium, Fibrosis, Focal | 2 2 1 2 1 1 4 1 3 | 9 1.9|
Peribronchial, Hyperplasia, | | |
Histiocytic | 1 1 1 1 2 1 | 6 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1| | |
DAY ON TEST | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9| | |
| 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8| | A |
18 MG/M3 | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 12 |
Nephropathy | 2 1 2 1 2 2 | 6 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|
DAY ON TEST | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|
| 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Inflammation | 2 3 2 1 2 3 2 |
Parasite Metazoan | X |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + M + + + + +|
Hyperplasia, Lymphoid | |
Inflammation | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + M + + + + + + + + + M +|
Inflammation | 2 2 1|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis, Focal | 2|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Atrophy | 2|
Basophilic Focus | 2 1 1 2 1 2 3 1 1 1 |
Clear Cell Focus | 1 |
Degeneration, Cystic | 3 3 2 2|
Eosinophilic Focus | |
Fatty Change | 3 3 2 2 3 3 3 |
Fibrosis | 2 |
Inflammation, Focal, Granulomatous | 1 |
Necrosis, Focal | |
Thrombosis | |
Bile Duct, Hyperplasia | 4 1 1 4 2 2 4 3 3 4 3 3 1 3 4 3 1 1 2|
Centrilobular, Atrophy | 2 2 2 2 2 |
Centrilobular, Degeneration | 3 4 4 4 4 |
Centrilobular, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lobules, Atrophy | 2 1 1 1 1 1 3 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|
DAY ON TEST | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|
| 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 4 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 |
Ulcer | 2 4 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Mineralization | 3 |
Mesenteric Artery, Mineralization | 3 |
Mesenteric Artery, Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 1 2 3 1 3 3 1 2 1 2 2 1 2 2 2 3|
Atrium, Thrombosis | X X X X|
Epicardium, Hyperplasia | 3 |
Myocardium, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 2 3 3 3 2 2 |
Degeneration, Focal | |
Degeneration | 4 |
Hyperplasia, Focal | 2 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 1 4 1 2 2 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + I + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 3 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 4 |
Inflammation | 4 2 3 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|
DAY ON TEST | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|
| 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation | 2 3 2 3 2 1 2 1 3 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation | 1|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 3 3 3 |
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Atrophy | 3 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + + + + + + + + + M + +|
Atrophy | 3 3 |
Hemorrhage, Acute | 3 |
Hemorrhage, Chronic | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hemorrhage, Acute | 3 |
Hemorrhage, Chronic | 3 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hemorrhage, Acute | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Congestion, Chronic | 4|
Hematopoietic Cell Proliferation | |
Infarct | 3 3 3|
Inflammation, Focal, Granulomatous | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + M +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tail, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|
DAY ON TEST | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|
| 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X |
Coccygeal, Necrosis | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + I + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 1 1 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Crystals, Focal | 1 |
Hemorrhage, Chronic | 3 |
Infarct | 2 |
Inflammation, Granulomatous | 1 |
Alveolar Epithelium, Hyperplasia | 3 2 2 |
Alveolus, Hemorrhage, Focal | 2 |
Artery, Thrombosis | |
Interstitium, Fibrosis, Focal | |
Interstitium, Mineralization | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Lumen, Foreign Body | 1 |
Mucosa, Inflammation, Suppurative | 2 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Cornea, Necrosis | 4 |
Lens, Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Nephropathy | 2 3 1 2 4 3 1 3 2 2 3 3 2 3 3 4 1 1 3 2 4 4 3|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|
DAY ON TEST | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|
| 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6| |
DAY ON TEST | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2| |
| 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2| A |
CONTROL | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + A + A + + + + + A A + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + A + A + M + + + A A + +| 42 |
Inflammation | 2 2 | 9 2.1|
Parasite Metazoan | X X | 3 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + A + + + + + A A + +| 43 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation | 1 | 1 1.0|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + M + + + + + + M A + A + + + + + A A + M| 38 |
Inflammation | 1 4 4 | 6 2.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | 2 | 1 2.0|
Necrosis, Focal | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + + + + + + + + + A + A + + + + A A A + +| 39 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + + + + + + + A + + A + A + + + + A A A + +| 40 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis, Focal | | 1 2.0|
Atrophy | | 1 2.0|
Basophilic Focus | 1 1 2 3 2 2 1 1| 18 1.6|
Clear Cell Focus | 1 1 | 3 1.0|
Degeneration, Cystic | 2 1 1 2 3 | 9 2.1|
Eosinophilic Focus | 1 2 | 2 1.5|
Fatty Change | 2 2 2 3 2 1 2 2 2| 16 2.3|
Fibrosis | | 1 2.0|
Inflammation, Focal, Granulomatous | 2 2 | 3 1.7|
Necrosis, Focal | 2 2 1 | 3 1.7|
Thrombosis | X | 1 |
Bile Duct, Hyperplasia | 2 2 4 2 1 2 1 3 3 4 3 2 3 4 2 4 1 2 1 2| 39 2.5|
Centrilobular, Atrophy | 1 1 3 2| 9 1.9|
Centrilobular, Degeneration | 4 3 4 | 8 3.8|
Centrilobular, Necrosis | 3 3 4 4 | 5 3.6|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Lobules, Atrophy | 2 1 1 | 11 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6| |
DAY ON TEST | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2| |
| 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2| A |
CONTROL | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | | 1 2.0|
Mineralization | 4 | 1 4.0|
Ulcer | 3 4 | 5 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 3 1 4 2 | 6 2.5|
Ulcer | | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 4 |
Aorta, Mineralization | 2 4 | 3 3.0|
Mesenteric Artery, Mineralization | 2 3 | 3 2.7|
Mesenteric Artery, Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 2 2 3 2 2 2 3 1 2 3 2 3 3 2 2 3 2 1 2 2 2| 42 2.0|
Atrium, Thrombosis | X X X X X | 9 |
Epicardium, Hyperplasia | | 1 3.0|
Myocardium, Mineralization | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Fatty | 2 | 8 2.5|
Degeneration, Focal | 3 | 1 3.0|
Degeneration | | 1 4.0|
Hyperplasia, Focal | 2 2 2 2 3 3 1 3 1| 11 2.0|
Necrosis, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 4 1 3 3 4 4 4 2 4| 19 2.6|
Bilateral, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + M + + M + + + + + + + + + + + +| 45 |
Hyperplasia | 3 3 3 | 6 2.8|
Bilateral, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + I + +| 47 |
Pars Distalis, Hyperplasia | 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + A A + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6| |
DAY ON TEST | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2| |
| 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2| A |
CONTROL | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 1 3 | 5 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Hyperplasia | | 3 4.0|
Inflammation | 1 | 7 2.4|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 2.0|
Inflammation | 3 4 3 2 3 2 2 1 1 2 2 | 22 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 2.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 4 4 4 3 3 3 3 3 3 | 14 3.4|
Interstitial Cell, Hyperplasia | 1 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Myeloid Cell, Hyperplasia | 3| 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pancreatic, Atrophy | | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + + I M + + M + + M + + + M +| 41 |
Atrophy | | 2 3.0|
Hemorrhage, Acute | | 1 3.0|
Hemorrhage, Chronic | 2 2 2| 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M M M + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Atrophy | | 1 3.0|
Hemorrhage, Acute | | 1 3.0|
Hemorrhage, Chronic | 3 3 2 3 2| 6 2.7|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Hemorrhage, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6| |
DAY ON TEST | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2| |
| 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2| A |
CONTROL | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Congestion, Chronic | | 1 4.0|
Hematopoietic Cell Proliferation | 3| 1 3.0|
Infarct | | 3 3.0|
Inflammation, Focal, Granulomatous | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + M + + + + + + +| 45 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Tail, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | X X | 3 |
Coccygeal, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Compression | X X X X X | 5 |
Necrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 2 1 | 6 1.8|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 4 | 1 4.0|
Crystals, Focal | | 1 1.0|
Hemorrhage, Chronic | 2 | 2 2.5|
Infarct | | 1 2.0|
Inflammation, Granulomatous | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 5 2.0|
Alveolus, Hemorrhage, Focal | | 1 2.0|
Artery, Thrombosis | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6| |
DAY ON TEST | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2| |
| 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2| A |
CONTROL | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Interstitium, Fibrosis, Focal | 1 | 1 1.0|
Interstitium, Mineralization | 4 | 2 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 | 2 1.0|
Lumen, Foreign Body | | 1 1.0|
Mucosa, Inflammation, Suppurative | 1 | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cataract | 4 | 1 4.0|
Cornea, Necrosis | | 1 4.0|
Lens, Cataract | 4 | 1 4.0|
Retina, Degeneration | 4 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 3 |
Nephropathy | 2 3 3 2 4 3 3 4 1 3 4 2 4 4 3 2 3 2 4 1 2 3| 45 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|
| 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|
6 MG/M3 | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + A + + + + + + + + A A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A A + + + + + A A + + + + + + + + A A|
Hemorrhage | 4 |
Inflammation | 1 |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + A + + + + + + + + A A|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + A + + + + + M A + + + + + + + + A A|
Inflammation | 1 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + A + + + + + + + + A A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + + + + + + + A A|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A A + A + + + A A + + + + + + + A A A|
Hyperplasia, Lymphoid | |
Lymphatic, Ectasia | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A A + A + + + A A + + + + + + + + A A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 1 1 1 1 2 2 2 |
Clear Cell Focus | 2 2 1 2 1 |
Congestion | 3 |
Degeneration, Cystic | 2 1 2 1 2 1 2 3 2 2|
Eosinophilic Focus | 1 1 1 1 |
Fatty Change | 3 3 2 2 |
Hematocyst | |
Inflammation, Focal, Granulomatous | |
Bile Duct, Hyperplasia | 2 4 1 2 1 2 1 3 3 1 1 4 2 2 2 3 2 2 1 3 2 1 1|
Centrilobular, Atrophy | 3 4 |
Centrilobular, Degeneration | 4 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + A|
Lobules, Atrophy | 1 1 2 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Mineralization | 3 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Mineralization | 4 3 |
Ulcer | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Mineralization | 3 3 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|
| 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|
6 MG/M3 | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Mineralization | 3 3 |
Mesenteric Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 2 1 1 2 2 2 2 2 3 2 1 2 3 2 2 2 2 2 1 1|
Atrium, Thrombosis | X X X X |
Myocardium, Inflammation | |
Myocardium, Mineralization | 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + I + + + + + + + + + + + +|
Hyperplasia | 2 2 2 4|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + M + M + + + + +|
Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Cyst | 3 |
Pars Distalis, Hyperplasia | 3 2 1 1 1 1 |
Pars Nervosa, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + A A|
C-Cell, Hyperplasia | 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + M|
Inflammation | 3 2 3 2 3 3 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + M + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 |
Hyperplasia, Lymphoid | 1 2 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|
| 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|
6 MG/M3 | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation | 2 |
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Chronic | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Histiocytic | 2 3 2 3 2 3 2 2 2 3 2 3 3 2 4 1 2 2 2 3 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 4|
Hyperplasia, Histiocytic | 2 3 1 2 2 2 3 2 1 3 2 3 2 2 1 1 3 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3 3 4 |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + M + M + + + + + + + + + + I + M + + + + + + + M|
Atrophy | 4 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X |
Pelvis, Fracture | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hemorrhage | |
Necrosis, Focal | 4 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|
DAY ON TEST | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|
| 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|
6 MG/M3 | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 1 2 2 2 1 1 1 1 3 3 1 1 2 2 2 1 2 2 1 3 1 1 2 2 2|
Inflammation, Suppurative | 3 |
Mineralization | 3 |
Alveolar Epithelium, Hyperplasia | 1 1 1 2 1 1 1 2 1 2 1 1 1 2 |
Interstitium, Fibrosis, Focal | 1 1 1 1 1 1 1 |
Interstitium, Mineralization | 3 |
Peribronchial, Hyperplasia, | |
Histiocytic | 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mucosa, Inflammation, Suppurative | 3 4 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hydronephrosis | 3 |
Nephropathy | 3 2 1 4 3 2 1 2 4 2 3 1 3 3 4 3 1 4 4 3 2 2 1 |
Medulla, Inflammation | |
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7| |
DAY ON TEST | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4| |
| 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
6 MG/M3 | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + A + + + A + + + + A + + + A + + A + + +| 38 |
Hemorrhage | | 1 4.0|
Inflammation | 3| 2 2.0|
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + A + + + + + + + + + + + + + + + A + + +| 43 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + A + + + M + + + + + + + + + + + + + + +| 41 |
Inflammation | | 1 1.0|
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + A + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + A + + +| 44 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + + A + + A + A + + + A + + A + + A| 34 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Lymphatic, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + + + + + A + + + + + A + + A + + +| 38 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 1 1 2 1 2 1 2 1 | 18 1.4|
Clear Cell Focus | 1 2 | 7 1.6|
Congestion | | 1 3.0|
Degeneration, Cystic | 2 1 1 2 1 1 2 | 17 1.6|
Eosinophilic Focus | 2 3 3 | 7 1.7|
Fatty Change | 3 1 2 2 3 3 1 2 2 2 | 14 2.2|
Hematocyst | X | 1 |
Inflammation, Focal, Granulomatous | 1 | 1 1.0|
Bile Duct, Hyperplasia | 4 1 1 4 3 1 3 2 2 1 1 1 3 1 2 2 1 2 3 2 2 1 2| 46 2.0|
Centrilobular, Atrophy | 2 3 | 4 3.0|
Centrilobular, Degeneration | 4 2 3 2 4 3 3 3 | 12 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + A + + +| 46 |
Lobules, Atrophy | 2 1| 7 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + A + + +| 47 |
Mineralization | 3 4 1 | 4 2.8|
Ulcer | 3 4 4 1 | 5 3.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + A + + +| 47 |
Mineralization | 3 3 4 1 | 6 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7| |
DAY ON TEST | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4| |
| 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
6 MG/M3 | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 5 |
Aorta, Mineralization | 4 3 3 | 5 3.2|
Mesenteric Artery, Mineralization | 4 3 3 | 5 3.2|
Mesenteric Artery, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 3 2 2 3 3 2 1 3 3 3 2 2 3 2 1 2 2 2 1 2 1 2 2| 47 1.9|
Atrium, Thrombosis | X | 5 |
Myocardium, Inflammation | 2 | 1 2.0|
Myocardium, Mineralization | 4 2 4 2 | 6 2.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 4 2 2 | 4 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 3 1 2 2| 8 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + A + M + M + M + + M + + + + + + A + + +| 41 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + M + + +| 45 |
Hyperplasia | 4 1 2 3 3 2 3 | 11 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 4 | 1 4.0|
Cyst | | 1 3.0|
Pars Distalis, Hyperplasia | 1 1 | 8 1.4|
Pars Nervosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + A + + +| 46 |
C-Cell, Hyperplasia | 2 3 | 7 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spermatocele | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 2 | 2 1.5|
__________________________________________________________________________|____________|
Prostate | M M + + + M + + + + + + + + + + + + A + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7| |
DAY ON TEST | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4| |
| 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
6 MG/M3 | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation | 2 3 3 4 2 2 | 14 2.6|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 4 3 3 4 3 | 11 3.1|
Hyperplasia, Lymphoid | | 2 1.5|
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
Atrophy, Focal | | 1 3.0|
Inflammation | | 1 2.0|
Myelofibrosis | | 1 2.0|
Myeloid Cell, Hyperplasia | 3 | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | | 1 3.0|
Hyperplasia, Histiocytic | 2 4 1 2 3 2 1 3 3 2 2 3 2 3 4 3 2 3 3 3 3 3| 44 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + I + + + + + + + + + + + + I + + +| 48 |
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Hyperplasia, Plasma Cell | 3 3| 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Hemorrhage | 3 | 3 3.3|
Hyperplasia, Histiocytic | 1 3 1 2 3 3 1 3 2 2 2 3 4 3 3 3 3 3 3 2| 40 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + I + + + + + + A + + +| 48 |
Hemorrhage | 3 | 2 3.5|
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 4 | 5 3.4|
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 | 2 3.0|
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + I + + + + + + + + + M + + + M M + M| 40 |
Atrophy | | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7| |
DAY ON TEST | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4| |
| 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
6 MG/M3 | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 X | 4 2.0|
Pelvis, Fracture | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 2 |
Hemorrhage | 3 | 1 3.0|
Necrosis, Focal | | 2 3.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 2 1 1 2 2 1 2 2 1 1 2 2 2 1 1 1 1 1 2 3 1 2 1 1 1| 50 1.6|
Inflammation, Suppurative | 4 | 2 3.5|
Mineralization | 4 3 2 | 4 3.0|
Alveolar Epithelium, Hyperplasia | 1 2 2 1 1 1 1 1 2 1 2 1| 26 1.3|
Interstitium, Fibrosis, Focal | 1 1 1 1 1 1 1 1 4| 16 1.2|
Interstitium, Mineralization | | 1 3.0|
Peribronchial, Hyperplasia, | | |
Histiocytic | 2 2 1 1 2 1 | 12 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + A + + + + + + + + A + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 | 1 1.0|
Mucosa, Inflammation, Suppurative | 3 2 | 5 2.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 | 3 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 3 | 1 3.0|
Retina, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7| |
DAY ON TEST | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4| |
| 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3| A |
6 MG/M3 | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | | 1 3.0|
Nephropathy | 1 4 3 3 3 1 4 2 4 4 3 3 1 4 1 1 3 2 2 2 1 3 3 2| 47 2.5|
Medulla, Inflammation | 3 | 1 3.0|
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + M + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|
| 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|
18 MG/M3 | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + A A + + + + + + A + + + + + + + + A + +|
Inflammation | 3 3 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation | |
Mineralization | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | M + + M M M + + + + + + M A + + + + M + + + A + M|
Inflammation | |
Metaplasia, Focal, Squamous | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + A + +|
Inflammation | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | A A + + A A + + + + + + + A + + + + + + + + A + A|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A + + + + + + + A + + + + + + + + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + A + +|
Basophilic Focus | 2 2 1 1 2 2 2 1 2 3 |
Clear Cell Focus | 1 2 |
Degeneration, Cystic | 2 1 2 1 |
Degeneration, Diffuse | |
Eosinophilic Focus | 1 1 1 1 1 |
Fatty Change | 3 1 3 3 3 4 1 2 3 |
Hyperplasia, Focal | |
Inflammation, Focal, Necrotizing | |
Necrosis, Focal | 3 |
Bile Duct, Hyperplasia | 4 2 2 3 4 3 2 1 3 2 4 4 1 1 1 2 2 1 2 1 1 1 2 2|
Centrilobular, Atrophy | 3 3 3 1 |
Centrilobular, Degeneration, Fatty | 4 |
Centrilobular, Degeneration | 2 3 4 1 3 4|
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | |
Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + A + +|
Lobules, Atrophy | 1 1 1 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + A + +|
Hyperkeratosis | 4|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|
| 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|
18 MG/M3 | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 4 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + A + +|
Mineralization | 3 3 |
Ulcer | 2 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Mineralization | 3 |
Mesenteric Artery, Aneurysm | X |
Mesenteric Artery, Inflammation | |
Mesenteric Artery, Mineralization | |
Mesenteric Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 2 1 2 2 1 3 1 1 1 1 2 2 2 2 1 2 1 3 2 2 2|
Atrium, Thrombosis | X X X X|
Myocardium, Mineralization | 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + A + +|
Degeneration, Fatty | 3 3|
Hyperplasia, Diffuse | 4 |
Hyperplasia, Focal | 2 1 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + M + + + + + + + + A + +|
Hyperplasia | 2 2 4 4 4 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M M + + + + + A + + + + + + + + A I +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + I + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 3 3 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Cyst | |
Pars Distalis, Hyperplasia | 3 3 2 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + A + +|
C-Cell, Hyperplasia | 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|
| 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|
18 MG/M3 | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation | 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | 3 |
Inflammation | 2 1 4 2 3 1 2 3 1 1 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 4 4 3 |
Hyperplasia, Focal, Lymphoid | 3 |
Interstitial Cell, Hyperplasia | 1 |
Serosa, Proliferation | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A A +|
Atrophy | 3 |
Myelofibrosis | 2 |
Myeloid Cell, Hyperplasia | 3 3 2 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 3 2 2 3 3 4 3 3 1 3 2 3 3 4 3 3 4 4 2 3 2 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + A + + + + I + + + + + +|
Hyperplasia, Plasma Cell | 3 |
Inflammation, Chronic Active | 3 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 3 2 3 3 3 3 3 4 2 3 3 3 4 4 3 2 3 4 4 3 3 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + A + +|
Atrophy | 4|
Autolysis | |
Cyst | |
Fibrosis, Focal | 3 4 |
Hematopoietic Cell Proliferation | 3 2 2|
Hyperplasia, Lymphoid | 3 |
Inflammation, Focal, Granulomatous | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|
| 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|
18 MG/M3 | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Infarct | 3 |
__________________________________________________________________________|
Spinal Cord | |
Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Granulomatous | 3 3 2 3 4 4 3 2 3 2 3 3 3 3 4 1 2 2 2 2 2 1 2 2|
Alveolar Epithelium, Hyperplasia | 1 2 2 2 1 2 1 1 2 1 1 2 2 1 2 1 2|
Alveolus, Metaplasia, Squamous | 1 |
Interstitium, Fibrosis, Focal | 2 3 2 1 3 1 1 1 1 2 2 2 1 2 2 1 1 |
Interstitium, Mineralization | 3 |
Peribronchial, Hyperplasia, | |
Histiocytic | 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | |
Mucosa, Inflammation, Suppurative | 2 |
Respiratory Epithelium, Hyperplasia | 2 2 1 3 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Inflammation, Chronic | 4 |
Cornea, Inflammation, Necrotizing | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +|
Calculus Micro Observation Only | |
Cyst | |
Hydronephrosis | |
Nephropathy | 1 4 2 2 2 3 4 4 3 2 1 2 3 3 4 3 2 1 4 4 4 1 |
Medulla, Inflammation | |
__________________________________________________________________________|
Ureter | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
_____________________________________________________________________________________________________________________
| 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|
| 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|
ANIMAL ID | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|
18 MG/M3 | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urethra | + |
Fibrosis | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + A + + + + + + + + A + +|
Calculus Gross Observation | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8| |
DAY ON TEST | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0| |
| 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| A |
18 MG/M3 | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + I + + + + + + + + + + +| 49 |
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + A + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + A + + + + + A A + + A + + + + + A + A +| 37 |
Inflammation | 2 2 | 5 2.6|
Parasite Metazoan | X X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + A + + + + + + + + A| 46 |
Inflammation | 3 | 1 3.0|
Mineralization | | 1 3.0|
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + M + + M M + + + + M A + + + + + + M + +| 34 |
Inflammation | 1 | 1 1.0|
Metaplasia, Focal, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + + + + + + A + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + A + + + + + + + + +| 46 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + A M A + + + + + + + + + A + + + + + + A A A| 35 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + A + + + + + + + + + A + + + + + + + A A| 40 |
__________________________________________________________________________|____________|
Liver | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Basophilic Focus | 2 1 1 1 2 2 1 1 1 | 19 1.6|
Clear Cell Focus | 1 2 | 4 1.5|
Degeneration, Cystic | 2 1 1 2 1 | 9 1.4|
Degeneration, Diffuse | 3 | 1 3.0|
Eosinophilic Focus | 2 2| 7 1.3|
Fatty Change | 3 2 3 | 12 2.6|
Hyperplasia, Focal | 3 | 1 3.0|
Inflammation, Focal, Necrotizing | 1 | 1 1.0|
Necrosis, Focal | | 1 3.0|
Bile Duct, Hyperplasia | 2 1 4 1 2 1 2 2 1 2 2 1 2 3 3 1 3 1 3 2| 44 2.0|
Centrilobular, Atrophy | 2 4 3 | 7 2.7|
Centrilobular, Degeneration, Fatty | | 1 4.0|
Centrilobular, Degeneration | 2 4 4 | 9 3.0|
Centrilobular, Necrosis | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Lobules, Atrophy | 1 1 2 | 8 1.6|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8| |
DAY ON TEST | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0| |
| 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| A |
18 MG/M3 | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperkeratosis | | 1 4.0|
Mineralization | 4 | 1 4.0|
Ulcer | 1 4 4 2 | 8 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Mineralization | 4 4 1 1 | 6 2.7|
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + | 5 |
Aorta, Mineralization | 4 3 3 | 4 3.3|
Mesenteric Artery, Aneurysm | X | 2 |
Mesenteric Artery, Inflammation | 4 | 1 4.0|
Mesenteric Artery, Mineralization | 4 3 3 | 3 3.3|
Mesenteric Artery, Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 3 2 2 2 1 1 2 3 3 1 2 1 2 3 2 1 2 2 1 2 3 2 2| 50 1.8|
Atrium, Thrombosis | X X X X X X X | 11 |
Myocardium, Mineralization | 4 3 2 | 5 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Degeneration, Fatty | | 2 3.0|
Hyperplasia, Diffuse | 4 | 2 4.0|
Hyperplasia, Focal | 1 1 2 1 | 9 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 4 2 4 | 8 3.3|
Bilateral, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + M + + + + + + + + + + + + + + + +| 43 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + M + +| 46 |
Hyperplasia | 4 2 3 3 3 2 | 12 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
Pars Distalis, Hyperplasia | 3 4 | 7 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8| |
DAY ON TEST | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0| |
| 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| A |
18 MG/M3 | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + A + A + + + + + + + + + + + + + + + + M + +| 46 |
C-Cell, Hyperplasia | | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Penis | + | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Hyperplasia | 2 | 1 2.0|
Inflammation | 3 3 2| 5 2.8|
__________________________________________________________________________|____________|
Prostate | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 1 3.0|
Inflammation | 3 3 2 1 4 4 3 4 | 19 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + A + A + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 4 4 4 3 2 3 4 3 | 16 3.3|
Hyperplasia, Focal, Lymphoid | | 1 3.0|
Interstitial Cell, Hyperplasia | 3 1 | 3 1.7|
Serosa, Proliferation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | 3 | 2 3.0|
Myelofibrosis | | 1 2.0|
Myeloid Cell, Hyperplasia | 3 | 6 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Histiocytic | 4 3 3 2 3 2 4 3 4 3 3 2 3 3 4 3 4 3 3 2 4 3 2 4| 47 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Plasma Cell | 3 2 2 3 | 5 2.6|
Inflammation, Chronic Active | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + I + + + + + + + + + + + + I + + + + + + + + + +| 47 |
Hyperplasia, Histiocytic | 1 4 2 1 4 3 4 3 3 2 3 2 3 2 4 3 2 4 4 3 3| 44 2.9|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + A + + + + + A + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 3 3 | 3 3.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8| |
DAY ON TEST | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0| |
| 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| A |
18 MG/M3 | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 | 2 3.5|
Autolysis | 3 | 1 3.0|
Cyst | X | 1 |
Fibrosis, Focal | | 2 3.5|
Hematopoietic Cell Proliferation | | 3 2.3|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Focal, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M I + A + + + + + + + + M + + + + M + + M + + + M| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | X X X | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | X | 2 |
Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 3 |
Inflammation, Granulomatous | 2 2 2 2 2 4 2 2 2 2 2 2 2 2 4 2 2 2 2 2 2 2 2 2 2| 49 2.3|
Alveolar Epithelium, Hyperplasia | 2 1 2 2 1 3 3 2 2 1 1 1 2 3 1 1 2 3 1 2 2| 38 1.7|
Alveolus, Metaplasia, Squamous | 1 | 2 1.0|
Interstitium, Fibrosis, Focal | 1 1 3 1 1 4 1 1 1 4 4 1 4 1 1 1| 33 1.8|
Interstitium, Mineralization | 3 3 1 | 4 2.5|
Peribronchial, Hyperplasia, | | |
Histiocytic | 2 2 2 2 1 2| 8 1.9|
__________________________________________________________________________|____________|
Nose | + + + A + + + + + + + + + + + + + + + + + A A + +| 47 |
Lumen, Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8| |
DAY ON TEST | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0| |
| 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| A |
18 MG/M3 | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Inflammation, Suppurative | 2 | 2 2.0|
Respiratory Epithelium, Hyperplasia | 1 2 1 1 1 1 1 1 | 14 1.4|
__________________________________________________________________________|____________|
Trachea | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | 2 | 2 2.5|
Inflammation, Chronic | | 1 4.0|
Cornea, Inflammation, Necrotizing | 4 | 1 4.0|
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Calculus Micro Observation Only | X | 1 |
Cyst | X | 1 |
Hydronephrosis | 3 | 1 3.0|
Nephropathy | 3 4 1 4 1 1 4 4 3 1 2 3 4 2 1 3 1 4 3 3 2| 43 2.6|
Medulla, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ureter | + | 1 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Calculus Gross Observation | X | 1 |
Mucosa, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7| | |
DAY ON TEST | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3| | |
| 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1| | A |
CONTROL | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + | 11 |
Parasite Metazoan | 2 X 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 11 |
Parasite Metazoan | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 11 |
Parasite Metazoan | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + | 11 |
Basophilic Focus | 1 1 | 2 1.0|
Fatty Change | 1 | 1 1.0|
Hyperplasia, Focal | 3 | 1 3.0|
Necrosis, Coagulative, Multifocal | 2 | 1 2.0|
Thrombosis | X | 1 |
Bile Duct, Hyperplasia | 1 1 1 2 1 | 5 1.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 11 |
Cardiomyopathy | 2 2 1 1 2 2 | 6 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | M + + + + + + + + + + | 10 |
Hyperplasia | 1 | 1 1.0|
Bilateral, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A M | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + M + M M | 6 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7| | |
DAY ON TEST | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3| | |
| 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1| | A |
CONTROL | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + | 11 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 11 |
C-Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + M + + + + M | 9 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + M | 10 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + | 11 |
Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 11 |
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + | 10 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + | 11 |
Congestion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + | 10 |
Depletion Lymphoid | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 11 |
Congestion, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + | 11 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7| | |
DAY ON TEST | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3| | |
| 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1| | A |
CONTROL | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + | 11 |
Inflammation, Granulomatous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 11 |
Inflammation, Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Zymbal's Gland | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 11 |
Inflammation, Chronic | 3 | 1 3.0|
Nephropathy | 2 2 3 3 | 4 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 11 |
Calculus Gross Observation, Single | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7| | |
DAY ON TEST | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3| | |
| 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3| | A |
6 MG/M3 | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + M M M M + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 |
Parasite Metazoan | 1 2 1 X 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 |
Peyer's Patch, Hyperplasia, Focal, | | |
Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 15 |
Basophilic Focus | 1 1 2 1 | 4 1.3|
Inflammation, Focal, Subacute | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 1 1 | 9 1.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 15 |
Cardiomyopathy | 2 2 2 1 2 1 2 1 | 8 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 15 |
Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 15 |
Hyperplasia | 2 1 2 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 15 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M + + + + + + M M M + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + M + | 14 |
Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7| | |
DAY ON TEST | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3| | |
| 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3| | A |
6 MG/M3 | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + M + | 13 |
C-Cell, Hyperplasia | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + | 15 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 15 |
Atrophy | 2 | 1 2.0|
Interstitial Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 15 |
Hyperplasia, Histiocytic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + | 15 |
Hyperplasia, Histiocytic | 2 2 3 2 2 2 1 2 1 2 2 3 | 12 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + M + + M + + | 12 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + M + + + + + + M M + + | 11 |
Hyperplasia, Histiocytic | 2 2 2 1 2 1 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 |
Hyperplasia, Histiocytic | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 15 |
Infarct | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + M + + + + | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + M + + + + + + + + + M | 11 |
Hyperplasia, Cystic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7| | |
DAY ON TEST | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3| | |
| 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3| | A |
6 MG/M3 | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 15 |
Inflammation, Granulomatous | 2 1 2 1 2 2 2 1 1 2 1 1 2 1 1 | 15 1.5|
Alveolar Epithelium, Hyperplasia | 1 1 1 2 1 1 1 1 1 2 2 1 | 12 1.3|
Interstitium, Fibrosis, Focal | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Peribronchial, Hyperplasia, | | |
Histiocytic | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 15 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 15 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Zymbal's Gland | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 15 |
Nephropathy | 2 2 2 1 3 1 3 2 1 | 9 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 15 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 5| 3| 7| 1| 7| 3| 6| 5| 5| 6| 1| 6| 1| 7| 7| 7| 5| 6| 7| | |
DAY ON TEST | 5| 3| 3| 5| 3| 0| 9| 2| 3| 2| 6| 1| 2| 9| 5| 9| 3| 3| 3| 5| 5| 1| | |
| 7| 1| 3| 6| 3| 4| 2| 4| 3| 7| 8| 0| 9| 3| 1| 4| 0| 8| 8| 6| 1| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 4| 5| 5| 7| 7| 7| 7| 9| 0| 0| 1| 2| 2| 4| 4| 4| 5| 6| 6| 7| 7| | A |
18 MG/M3 | 7| 8| 3| 4| 0| 1| 3| 9| 9| 0| 4| 8| 1| 3| 1| 8| 9| 0| 5| 9| 2| 3| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + | 9 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
Parasite Metazoan | 1 2 1 2 | 4 1.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | 1 1 1 1 | 4 1.0|
Congestion | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Tongue | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 2 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M M + + | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 5| 3| 7| 1| 7| 3| 6| 5| 5| 6| 1| 6| 1| 7| 7| 7| 5| 6| 7| | |
DAY ON TEST | 5| 3| 3| 5| 3| 0| 9| 2| 3| 2| 6| 1| 2| 9| 5| 9| 3| 3| 3| 5| 5| 1| | |
| 7| 1| 3| 6| 3| 4| 2| 4| 3| 7| 8| 0| 9| 3| 1| 4| 0| 8| 8| 6| 1| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 4| 5| 5| 7| 7| 7| 7| 9| 0| 0| 1| 2| 2| 4| 4| 4| 5| 6| 6| 7| 7| | A |
18 MG/M3 | 7| 8| 3| 4| 0| 1| 3| 9| 9| 0| 4| 8| 1| 3| 1| 8| 9| 0| 5| 9| 2| 3| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + I + I + + + + + | 8 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
Hyperplasia, Histiocytic | 3 2 2 3 2 3 3 4 4 2 | 10 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + | 9 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 10 |
Congestion | 2 | 1 2.0|
Hyperplasia, Histiocytic | 3 2 2 2 3 4 2 | 7 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + | 9 |
Lobules, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Inflammation, Granulomatous | 3 2 3 3 3 2 2 3 1 2 | 10 2.4|
Alveolar Epithelium, Hyperplasia | 1 1 2 2 2 1 1 | 7 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05079-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TALC Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:39:13
__________________________________________________________________________________________________________________________________
| 5| 7| 3| 5| 3| 7| 1| 7| 3| 6| 5| 5| 6| 1| 6| 1| 7| 7| 7| 5| 6| 7| | |
DAY ON TEST | 5| 3| 3| 5| 3| 0| 9| 2| 3| 2| 6| 1| 2| 9| 5| 9| 3| 3| 3| 5| 5| 1| | |
| 7| 1| 3| 6| 3| 4| 2| 4| 3| 7| 8| 0| 9| 3| 1| 4| 0| 8| 8| 6| 1| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 4| 4| 5| 5| 7| 7| 7| 7| 9| 0| 0| 1| 2| 2| 4| 4| 4| 5| 6| 6| 7| 7| | A |
18 MG/M3 | 7| 8| 3| 4| 0| 1| 3| 9| 9| 0| 4| 8| 1| 3| 1| 8| 9| 0| 5| 9| 2| 3| | L |
LUNG TOX | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Interstitium, Fibrosis, Focal | 1 1 1 1 2 1 2 | 7 1.3|
Peribronchial, Hyperplasia, | | |
Histiocytic | 1 2 2 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 1 2 4 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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