Skip to Main Navigation
Skip to Page Content

COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/2511

TDMS Study 05080-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        ALLYL GLYCIDYL ETHER


NTP Experiment-Test: 05080-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17




       Facility:  Battelle Northwest

       Chemical CAS #:  106-92-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              10            3            6                                                  
    Moribund                                           7            5            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           41           41                                                  
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)         (6)          (42)                                                
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
   Intestine Large, Colon                             (49)         (9)          (49)                                                
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
   Intestine Small, Ileum                             (47)         (7)          (47)                                                
      Hyperplasia, Lymphoid                            1 (2%)                    3 (6%)                                             
   Liver                                              (50)         (15)         (50)                                                
      Basophilic Focus                                              1 (7%)                                                          
      Cyst                                                          2 (13%)                                                         
      Focal Cellular Change                                                      1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (4%)       1 (7%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Inflammation, Chronic, Multifocal                4 (8%)                    1 (2%)                                             
      Leukocytosis                                     1 (2%)                                                                       
      Hepatocyte, Cytomegaly                           1 (2%)                                                                       
   Mesentery                                          (13)         (4)          (8)                                                 
      Hyperplasia, Lymphoid                            2 (15%)                   2 (25%)                                            
      Inflammation, Chronic                                         1 (25%)                                                         
      Inflammation, Suppurative                        2 (15%)                                                                      
      Fat, Necrosis                                    1 (8%)       1 (25%)      1 (13%)                                            
   Pancreas                                           (49)         (10)         (50)                                                
      Atrophy                                          3 (6%)       1 (10%)      1 (2%)                                             
      Cyst                                                          1 (10%)      1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)       1 (10%)                                                         
      Inflammation, Chronic                                         1 (10%)                                                         
      Duct, Ectasia                                    1 (2%)                                                                       
   Salivary Glands                                    (50)         (9)          (50)                                                
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
      Inflammation, Chronic, Multifocal                2 (4%)       1 (11%)      1 (2%)                                             
   Stomach, Forestomach                               (50)         (12)         (49)                                                
      Granuloma                                        1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperkeratosis                                   1 (2%)       1 (8%)       2 (4%)                                             
      Hyperplasia                                      1 (2%)       1 (8%)       2 (4%)                                             
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Ulcer                                                                      2 (4%)                                             
   Stomach, Glandular                                 (49)         (10)         (48)                                                
      Atrophy                                          1 (2%)                    2 (4%)                                             
      Atrophy, Focal                                                1 (10%)                                                         
      Cyst                                             1 (2%)                                                                       
   Tooth                                              (3)                       (1)                                                 
      Peridontal Tissue, Inflammation, Chronic         1 (33%)                   1 (100%)                                           
      Peridontal Tissue, Inflammation, Suppurative     2 (67%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (9)          (50)                                                
      Inflammation, Acute                              1 (2%)                                                                       
   Heart                                              (50)         (9)          (50)                                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Atrium, Inflammation, Focal, Suppurative         1 (2%)                                                                       
      Myocardium, Inflammation, Chronic                             1 (11%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (47)         (9)          (48)                                                
      Subcapsular, Hyperplasia                        42 (89%)      8 (89%)     46 (96%)                                            
   Adrenal Gland, Cortex                              (47)         (8)          (48)                                                
      Accessory Adrenal Cortical Nodule                2 (4%)                    1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Degeneration                                    37 (79%)      5 (63%)     40 (83%)                                            
      Fibrosis                                        36 (77%)      5 (63%)     40 (83%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
   Adrenal Gland, Medulla                             (47)         (7)          (47)                                                
      Cyst                                                                       1 (2%)                                             
   Pituitary Gland                                    (44)         (17)         (45)                                                
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      15 (34%)      6 (35%)      9 (20%)                                            
   Thyroid Gland                                      (50)         (10)         (50)                                                
      C-Cell, Hyperplasia                              1 (2%)                    1 (2%)                                             
      Follicle, Degeneration                           1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     3 (6%)       1 (10%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)                       (1)                                                 
      Abscess                                          1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (19)         (50)                                                
      Atrophy                                                                    1 (2%)                                             
      Cyst                                            14 (29%)     10 (53%)     18 (36%)                                            
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                        4 (8%)       3 (16%)      2 (4%)                                             
      Capsule, Fibrosis                                                          1 (2%)                                             
      Capsule, Inflammation, Chronic                                             1 (2%)                                             
      Capsule, Mineralization                                                    1 (2%)                                             
   Uterus                                             (50)         (24)         (50)                                                
      Endometrium, Hyperplasia, Cystic                36 (72%)     22 (92%)     29 (58%)                                            
      Endometrium, Inflammation, Acute                 1 (2%)                                                                       
      Endometrium, Inflammation, Suppurative           3 (6%)       2 (8%)       1 (2%)                                             
      Endometrium, Necrosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (49)         (9)          (50)                                                
      Leukocytosis                                     1 (2%)                                                                       
   Bone Marrow                                        (50)         (35)         (48)                                                
      Hyperplasia                                      1 (2%)                                                                       
      Myelofibrosis                                   36 (72%)     32 (91%)     45 (94%)                                            
   Lymph Node                                         (48)         (11)         (48)                                                
      Mesenteric, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Renal, Hyperplasia, Lymphoid                                               1 (2%)                                             
      Renal, Inflammation, Suppurative                 1 (2%)                                                                       
   Lymph Node, Bronchial                              (38)         (7)          (37)                                                
      Hyperplasia, Lymphoid                            1 (3%)                    5 (14%)                                            
   Lymph Node, Mandibular                             (42)         (6)          (40)                                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Lymphoid                            8 (19%)                   8 (20%)                                            
      Infiltration Cellular, Histiocyte                             1 (17%)                                                         
      Inflammation, Suppurative                        1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Spleen                                             (50)         (18)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 6 (12%)      3 (17%)      4 (8%)                                             
      Hyperplasia, Lymphoid                            8 (16%)      1 (6%)      10 (20%)                                            
   Thymus                                             (34)         (8)          (42)                                                
      Atrophy                                          1 (3%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (3%)                    1 (2%)                                             
      Inflammation, Necrotizing                        1 (3%)                                                                       
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mediastinum, Inflammation, Suppurative           1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (18)         (50)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Hair Follicle, Atrophy                           5 (10%)      8 (44%)      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (9)          (50)                                                
      Cranium, Fibrous Osteodystrophy                                            1 (2%)                                             
   Skeletal Muscle                                    (1)          (1)          (2)                                                 
      Back, Inflammation, Chronic                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (9)          (50)                                                
      Hypothalamus, Atrophy                            5 (10%)                   1 (2%)                                             
      Lateral Ventricle, Dilatation                    1 (2%)                                                                       
      Thalamus, Mineralization                         5 (10%)      1 (11%)      4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (9)          (50)                                                
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
   Lung                                               (50)         (9)          (50)                                                
      Hyperplasia, Lymphoid                            3 (6%)                    5 (10%)                                            
      Infiltration Cellular, Diffuse, Histiocyte                                 1 (2%)                                             
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Chronic, Multifocal               17 (34%)      2 (22%)     24 (48%)                                            
      Leukocytosis                                     2 (4%)       1 (11%)      1 (2%)                                             
      Alveolus, Granuloma                                                        1 (2%)                                             
      Bronchiole, Hyperplasia                          1 (2%)                                                                       
   Nose                                               (49)         (49)         (50)                                                
      Hemorrhage                                                                 1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Glands, Hyperplasia                             32 (65%)     46 (94%)     49 (98%)                                            
      Glands, Inflammation                                          1 (2%)                                                          
      Glands, Regeneration                                          1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      5 PPM        10 PPM                                                 
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mucosa, Inflammation                             1 (2%)                                                                       
      Mucosa, Inflammation, Acute                      1 (2%)                                                                       
      Mucosa, Inflammation, Suppurative                8 (16%)     48 (98%)     49 (98%)                                            
      Olfactory Epithelium, Metaplasia                 7 (14%)     48 (98%)     49 (98%)                                            
      Respiratory Epithelium, Dysplasia                                          3 (6%)                                             
      Respiratory Epithelium, Hyperplasia                          39 (80%)     48 (96%)                                            
      Respiratory Epithelium, Hyperplasia, Basal                                                                                    
          Cell                                                      2 (4%)       7 (14%)                                            
      Respiratory Epithelium, Metaplasia, Squamous                  9 (18%)     12 (24%)                                            
      Respiratory Epithelium, Regeneration             5 (10%)     47 (96%)     46 (92%)                                            
      Submucosa, Angiectasis, Focal                                              2 (4%)                                             
   Trachea                                            (50)         (9)          (49)                                                
      Metaplasia, Focal, Squamous                                                1 (2%)                                             
      Glands, Inflammation, Suppurative                1 (2%)                                                                       
      Mediastinum, Inflammation, Suppurative           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                       (2)                                                 
      Inflammation, Necrotizing                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (10)         (49)                                                
      Hyperplasia, Lymphoid                            4 (8%)                    1 (2%)                                             
      Inflammation, Chronic                           10 (20%)      3 (30%)     18 (37%)                                            
      Inflammation, Suppurative                        2 (4%)       1 (10%)                                                         
      Metaplasia, Focal, Osseous                                                 2 (4%)                                             
      Regeneration                                                               1 (2%)                                             
      Cortex, Cyst                                                  1 (10%)                                                         
      Cortex, Infarct                                  1 (2%)                                                                       
      Renal Tubule, Necrosis                                        1 (10%)                                                         
      Renal Tubule, Regeneration                       5 (10%)                   5 (10%)                                            
      Renal Tubule, Regeneration, Focal                1 (2%)                                                                       
   Urinary Bladder                                    (47)         (9)          (47)                                                
      Hyperplasia, Lymphoid                            3 (6%)                    4 (9%)                                             
      Inflammation, Chronic                           10 (21%)      3 (33%)      6 (13%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               7            2            1                                                  
    Moribund                                           5            9            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           39           46                                                  
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (45)         (5)          (48)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
   Intestine Large, Colon                             (47)         (10)         (49)                                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Rectum                            (47)         (10)         (47)                                                
      Inflammation, Suppurative                        2 (4%)                                                                       
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Small                                    (45)         (13)         (49)                                                
      Lymphoid Tissue, Hyperplasia                     1 (2%)                                                                       
   Intestine Small, Ileum                             (45)         (11)         (49)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Submucosa, Amyloid Deposition                    1 (2%)                                                                       
   Liver                                              (49)         (19)         (49)                                                
      Basophilic Focus                                              1 (5%)                                                          
      Cyst, Multiple                                                1 (5%)                                                          
      Developmental Malformation                       1 (2%)                                                                       
      Focal Cellular Change                            2 (4%)                    2 (4%)                                             
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Inflammation, Chronic, Multifocal                             1 (5%)       2 (4%)                                             
      Necrosis, Coagulative                            1 (2%)                    1 (2%)                                             
      Proliferation Connective Tissue                               1 (5%)                                                          
      Bile Duct, Cyst                                                            1 (2%)                                             
      Centrilobular, Fatty Change, Multifocal          1 (2%)                                                                       
      Serosa, Fibrosis                                 1 (2%)                                                                       
   Mesentery                                          (2)                       (1)                                                 
      Inflammation, Chronic                            1 (50%)                                                                      
   Pancreas                                           (49)         (12)         (49)                                                
      Cyst                                                          1 (8%)                                                          
      Fibrosis, Diffuse                                1 (2%)                                                                       
   Salivary Glands                                    (49)         (10)         (49)                                                
      Inflammation, Chronic                            2 (4%)                    4 (8%)                                             
   Stomach, Forestomach                               (50)         (15)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperkeratosis                                   3 (6%)       1 (7%)       1 (2%)                                             
      Hyperplasia, Squamous                                         1 (7%)                                                          
      Mineralization, Focal                            1 (2%)                                                                       
      Ulcer                                                         2 (13%)      2 (4%)                                             
   Stomach, Glandular                                 (50)         (15)         (49)                                                
      Atrophy                                          1 (2%)                                                                       
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Dysplasia, Focal                                 1 (2%)                                                                       
      Necrosis, Multifocal                             1 (2%)                                                                       
      Ulcer, Multiple                                               1 (7%)                                                          
   Tooth                                              (3)          (3)          (3)                                                 
      Abscess                                                       3 (100%)                                                        
      Developmental Malformation                       2 (67%)                                                                      
      Inflammation, Chronic, Focal                     1 (33%)                                                                      
      Peridontal Tissue, Inflammation, Chronic                                   3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (11)         (50)                                                
      Atrium, Thrombosis                               1 (2%)                                                                       
      Coronary Artery, Inflammation, Chronic, Focal    1 (2%)                                                                       
      Myocardium, Inflammation, Acute, Focal                                     1 (2%)                                             
      Myocardium, Inflammation, Chronic                                          2 (4%)                                             
      Valve, Inflammation, Chronic, Focal              1 (2%)                                                                       
      Valve, Pigmentation, Focal                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (11)         (50)                                                
      Subcapsular, Hyperplasia                        46 (94%)     10 (91%)     49 (98%)                                            
   Adrenal Gland, Cortex                              (49)         (11)         (49)                                                
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Degeneration, Focal                              2 (4%)                                                                       
      Hyperplasia, Focal                                                         2 (4%)                                             
      Hypertrophy, Focal                               1 (2%)                    1 (2%)                                             
   Pituitary Gland                                    (44)         (9)          (49)                                                
      Cyst                                                                       1 (2%)                                             
   Thyroid Gland                                      (50)         (10)         (49)                                                
      Follicular Cell, Hyperplasia                     4 (8%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Penis                                              (1)          (2)                                                              
      Inflammation, Necrotizing                        1 (100%)     1 (50%)                                                         
   Preputial Gland                                    (8)          (9)          (8)                                                 
      Cyst                                             2 (25%)      4 (44%)      5 (63%)                                            
      Cyst, Multiple                                                             1 (13%)                                            
      Inflammation, Chronic                            1 (13%)      1 (11%)                                                         
      Inflammation, Suppurative                        5 (63%)      3 (33%)                                                         
   Prostate                                           (45)         (11)         (44)                                                
      Inflammation, Suppurative                        2 (4%)                                                                       
   Seminal Vesicle                                    (47)         (10)         (44)                                                
      Dilatation                                       1 (2%)       1 (10%)                                                         
      Hemorrhage, Diffuse                              1 (2%)                                                                       
      Inflammation, Suppurative                        2 (4%)                                                                       
   Testes                                             (49)         (11)         (49)                                                
      Mineralization                                   2 (4%)                                                                       
      Bilateral, Atrophy                               2 (4%)                                                                       
      Interstitial Cell, Hyperplasia                   2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (43)         (15)         (45)                                                
      Mesenteric, Hemorrhage, Acute                                 1 (7%)                                                          
      Mesenteric, Hyperplasia                          1 (2%)                                                                       
   Lymph Node, Bronchial                              (29)         (7)          (29)                                                
      Edema                                            1 (3%)                                                                       
      Hyperplasia, Lymphoid                            1 (3%)                    1 (3%)                                             
   Lymph Node, Mandibular                             (34)         (9)          (33)                                                
      Hyperplasia, Lymphoid                            1 (3%)       1 (11%)      1 (3%)                                             
      Infiltration Cellular, Histiocyte                7 (21%)                   1 (3%)                                             
   Spleen                                             (49)         (16)         (49)                                                
      Atrophy                                                       1 (6%)       2 (4%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       2 (13%)      2 (4%)                                             
      Hyperplasia, Lymphoid                                                      3 (6%)                                             
      Capsule, Fibrosis                                1 (2%)                                                                       
   Thymus                                             (30)         (4)          (31)                                                
      Cyst                                             3 (10%)                                                                      
      Mediastinum, Inflammation, Chronic                                         1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (17)         (50)                                                
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Dermis, Abscess                                  1 (2%)                                                                       
      Epidermis, Necrosis, Acute                       1 (2%)                                                                       
      Hair Follicle, Atrophy                           3 (6%)       5 (29%)                                                         
      Prepuce, Inflammation, Suppurative               3 (6%)                                                                       
      Prepuce, Ulcer                                                3 (18%)                                                         
      Sebaceous Gland, Hyperplasia                                  1 (6%)                                                          
      Subcutaneous Tissue, Edema                                    1 (6%)                                                          
      Subcutaneous Tissue, Hemorrhage, Acute           1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Acute                      1 (6%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)       1 (6%)                                                          
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                  3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (50)                                                
      Cerebrum, Mineralization                                                   1 (2%)                                             
      Hypothalamus, Atrophy                                                      1 (2%)                                             
      Thalamus, Atrophy                                1 (2%)                                                                       
      Thalamus, Hemorrhage, Acute, Focal               1 (2%)                                                                       
      Thalamus, Mineralization                        29 (58%)      3 (27%)      8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (19)         (50)                                                
      Congestion, Diffuse                              1 (2%)                                                                       
      Granuloma                                                                  1 (2%)                                             
      Infiltration Cellular, Histiocyte                2 (4%)       1 (5%)       2 (4%)                                             
      Inflammation, Chronic, Multifocal               17 (34%)      3 (16%)     21 (42%)                                            
      Inflammation, Suppurative                                                  1 (2%)                                             
      Alveolus, Adenomatosis, Focal                    2 (4%)       1 (5%)                                                          
      Alveolus, Hyperplasia, Focal                     2 (4%)                                                                       
      Glands, Ectasia                                  8 (16%)                                                                      
      Glands, Inflammation, Suppurative                1 (2%)                                                                       
      Interstitium, Inflammation, Acute                3 (6%)                                                                       
   Nose                                               (50)         (50)         (50)                                                
      Glands, Dilatation                               1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05080-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 20:33:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      5 PPM        10 PPM                                                 
                                                   MALE         MALE         MALE                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Glands, Hyperplasia                              8 (16%)     47 (94%)     48 (96%)                                            
      Mucosa, Inflammation, Suppurative                2 (4%)      48 (96%)     47 (94%)                                            
      Olfactory Epithelium, Metaplasia                 4 (8%)      49 (98%)     50 (100%)                                           
      Respiratory Epithelium, Dysplasia                             1 (2%)       3 (6%)                                             
      Respiratory Epithelium, Dysplasia, Focal                                   1 (2%)                                             
      Respiratory Epithelium, Hyperplasia                          25 (50%)     40 (80%)                                            
      Respiratory Epithelium, Hyperplasia, Basal                                                                                    
          Cell                                                      1 (2%)       7 (14%)                                            
      Respiratory Epithelium, Metaplasia, Squamous                  4 (8%)       8 (16%)                                            
      Respiratory Epithelium, Regeneration                         46 (92%)     46 (92%)                                            
      Submucosa, Angiectasis                           1 (2%)       2 (4%)       5 (10%)                                            
   Trachea                                            (50)         (10)         (48)                                                
      Epithelium, Metaplasia, Squamous                                           1 (2%)                                             
      Glands, Dilatation                              41 (82%)                  27 (56%)                                            
      Mediastinum, Hyperplasia, Lymphoid               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (15)         (49)                                                
      Inflammation, Chronic                           39 (80%)      4 (27%)     30 (61%)                                            
      Inflammation, Suppurative                        4 (8%)       1 (7%)                                                          
      Capsule, Fibrosis                                             1 (7%)                                                          
      Cortex, Cyst                                                  2 (13%)                                                         
      Cortex, Metaplasia, Osseous                      1 (2%)                                                                       
      Medulla, Cyst                                                 1 (7%)                                                          
      Renal Tubule, Dilatation, Diffuse                1 (2%)                                                                       
      Renal Tubule, Regeneration                      32 (65%)      3 (20%)     32 (65%)                                            
      Renal Tubule, Regeneration, Multifocal                                     2 (4%)                                             
   Urinary Bladder                                    (49)         (11)         (49)                                                
      Calculus Micro Observation Only                               1 (9%)                                                          
      Inflammation, Chronic                            2 (4%)                                                                       
      Inflammation, Chronic, Multifocal                                          2 (4%)                                             
      Inflammation, Suppurative                        4 (8%)       1 (9%)                                                          
      Transitional Epithelium, Hyperplasia                          1 (9%)                                                          
      Transitional Epithelium, Necrosis                1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 75352-75352/75352


--multipart-boundary--