TDMS Study 05080-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
ALLYL GLYCIDYL ETHER
NTP Experiment-Test: 05080-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
Facility: Battelle Northwest
Chemical CAS #: 106-92-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05080-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 10 3 6
Moribund 7 5 3
Survivors
Terminal Sacrifice 33 41 41
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (6) (42)
Fibrosis 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Intestine Large, Colon (49) (9) (49)
Hyperplasia, Lymphoid 2 (4%)
Intestine Small, Ileum (47) (7) (47)
Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Liver (50) (15) (50)
Basophilic Focus 1 (7%)
Cyst 2 (13%)
Focal Cellular Change 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (7%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Chronic, Multifocal 4 (8%) 1 (2%)
Leukocytosis 1 (2%)
Hepatocyte, Cytomegaly 1 (2%)
Mesentery (13) (4) (8)
Hyperplasia, Lymphoid 2 (15%) 2 (25%)
Inflammation, Chronic 1 (25%)
Inflammation, Suppurative 2 (15%)
Fat, Necrosis 1 (8%) 1 (25%) 1 (13%)
Pancreas (49) (10) (50)
Atrophy 3 (6%) 1 (10%) 1 (2%)
Cyst 1 (10%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 1 (10%)
Inflammation, Chronic 1 (10%)
Duct, Ectasia 1 (2%)
Salivary Glands (50) (9) (50)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Inflammation, Chronic, Multifocal 2 (4%) 1 (11%) 1 (2%)
Stomach, Forestomach (50) (12) (49)
Granuloma 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05080-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperkeratosis 1 (2%) 1 (8%) 2 (4%)
Hyperplasia 1 (2%) 1 (8%) 2 (4%)
Hyperplasia, Squamous 1 (2%)
Ulcer 2 (4%)
Stomach, Glandular (49) (10) (48)
Atrophy 1 (2%) 2 (4%)
Atrophy, Focal 1 (10%)
Cyst 1 (2%)
Tooth (3) (1)
Peridontal Tissue, Inflammation, Chronic 1 (33%) 1 (100%)
Peridontal Tissue, Inflammation, Suppurative 2 (67%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (9) (50)
Inflammation, Acute 1 (2%)
Heart (50) (9) (50)
Fibrosis, Focal 1 (2%)
Inflammation, Chronic 1 (2%)
Atrium, Inflammation, Focal, Suppurative 1 (2%)
Myocardium, Inflammation, Chronic 1 (11%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (47) (9) (48)
Subcapsular, Hyperplasia 42 (89%) 8 (89%) 46 (96%)
Adrenal Gland, Cortex (47) (8) (48)
Accessory Adrenal Cortical Nodule 2 (4%) 1 (2%)
Cyst 1 (2%)
Degeneration 37 (79%) 5 (63%) 40 (83%)
Fibrosis 36 (77%) 5 (63%) 40 (83%)
Hematopoietic Cell Proliferation 1 (2%)
Adrenal Gland, Medulla (47) (7) (47)
Cyst 1 (2%)
Pituitary Gland (44) (17) (45)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 15 (34%) 6 (35%) 9 (20%)
Thyroid Gland (50) (10) (50)
C-Cell, Hyperplasia 1 (2%) 1 (2%)
Follicle, Degeneration 1 (2%)
Follicular Cell, Hyperplasia 3 (6%) 1 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05080-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (5) (1)
Abscess 1 (20%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (19) (50)
Atrophy 1 (2%)
Cyst 14 (29%) 10 (53%) 18 (36%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 4 (8%) 3 (16%) 2 (4%)
Capsule, Fibrosis 1 (2%)
Capsule, Inflammation, Chronic 1 (2%)
Capsule, Mineralization 1 (2%)
Uterus (50) (24) (50)
Endometrium, Hyperplasia, Cystic 36 (72%) 22 (92%) 29 (58%)
Endometrium, Inflammation, Acute 1 (2%)
Endometrium, Inflammation, Suppurative 3 (6%) 2 (8%) 1 (2%)
Endometrium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (49) (9) (50)
Leukocytosis 1 (2%)
Bone Marrow (50) (35) (48)
Hyperplasia 1 (2%)
Myelofibrosis 36 (72%) 32 (91%) 45 (94%)
Lymph Node (48) (11) (48)
Mesenteric, Hyperplasia, Lymphoid 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (2%)
Renal, Inflammation, Suppurative 1 (2%)
Lymph Node, Bronchial (38) (7) (37)
Hyperplasia, Lymphoid 1 (3%) 5 (14%)
Lymph Node, Mandibular (42) (6) (40)
Cyst 1 (2%)
Hyperplasia, Lymphoid 8 (19%) 8 (20%)
Infiltration Cellular, Histiocyte 1 (17%)
Inflammation, Suppurative 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Spleen (50) (18) (50)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 6 (12%) 3 (17%) 4 (8%)
Hyperplasia, Lymphoid 8 (16%) 1 (6%) 10 (20%)
Thymus (34) (8) (42)
Atrophy 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05080-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (3%) 1 (2%)
Inflammation, Necrotizing 1 (3%)
Inflammation, Suppurative 1 (2%)
Mediastinum, Inflammation, Suppurative 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (18) (50)
Inflammation, Suppurative 1 (2%)
Hair Follicle, Atrophy 5 (10%) 8 (44%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (9) (50)
Cranium, Fibrous Osteodystrophy 1 (2%)
Skeletal Muscle (1) (1) (2)
Back, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (9) (50)
Hypothalamus, Atrophy 5 (10%) 1 (2%)
Lateral Ventricle, Dilatation 1 (2%)
Thalamus, Mineralization 5 (10%) 1 (11%) 4 (8%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (9) (50)
Epithelium, Hyperplasia, Focal 1 (2%)
Lung (50) (9) (50)
Hyperplasia, Lymphoid 3 (6%) 5 (10%)
Infiltration Cellular, Diffuse, Histiocyte 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Multifocal 17 (34%) 2 (22%) 24 (48%)
Leukocytosis 2 (4%) 1 (11%) 1 (2%)
Alveolus, Granuloma 1 (2%)
Bronchiole, Hyperplasia 1 (2%)
Nose (49) (49) (50)
Hemorrhage 1 (2%)
Thrombosis 1 (2%)
Glands, Hyperplasia 32 (65%) 46 (94%) 49 (98%)
Glands, Inflammation 1 (2%)
Glands, Regeneration 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05080-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Mucosa, Inflammation 1 (2%)
Mucosa, Inflammation, Acute 1 (2%)
Mucosa, Inflammation, Suppurative 8 (16%) 48 (98%) 49 (98%)
Olfactory Epithelium, Metaplasia 7 (14%) 48 (98%) 49 (98%)
Respiratory Epithelium, Dysplasia 3 (6%)
Respiratory Epithelium, Hyperplasia 39 (80%) 48 (96%)
Respiratory Epithelium, Hyperplasia, Basal
Cell 2 (4%) 7 (14%)
Respiratory Epithelium, Metaplasia, Squamous 9 (18%) 12 (24%)
Respiratory Epithelium, Regeneration 5 (10%) 47 (96%) 46 (92%)
Submucosa, Angiectasis, Focal 2 (4%)
Trachea (50) (9) (49)
Metaplasia, Focal, Squamous 1 (2%)
Glands, Inflammation, Suppurative 1 (2%)
Mediastinum, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2)
Inflammation, Necrotizing 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (10) (49)
Hyperplasia, Lymphoid 4 (8%) 1 (2%)
Inflammation, Chronic 10 (20%) 3 (30%) 18 (37%)
Inflammation, Suppurative 2 (4%) 1 (10%)
Metaplasia, Focal, Osseous 2 (4%)
Regeneration 1 (2%)
Cortex, Cyst 1 (10%)
Cortex, Infarct 1 (2%)
Renal Tubule, Necrosis 1 (10%)
Renal Tubule, Regeneration 5 (10%) 5 (10%)
Renal Tubule, Regeneration, Focal 1 (2%)
Urinary Bladder (47) (9) (47)
Hyperplasia, Lymphoid 3 (6%) 4 (9%)
Inflammation, Chronic 10 (21%) 3 (33%) 6 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05080-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 7 2 1
Moribund 5 9 3
Survivors
Terminal Sacrifice 37 39 46
Moribund 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (45) (5) (48)
Inflammation, Suppurative 1 (2%)
Intestine Large, Colon (47) (10) (49)
Inflammation, Suppurative 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Large, Rectum (47) (10) (47)
Inflammation, Suppurative 2 (4%)
Parasite Metazoan 1 (2%)
Intestine Small (45) (13) (49)
Lymphoid Tissue, Hyperplasia 1 (2%)
Intestine Small, Ileum (45) (11) (49)
Hyperplasia, Lymphoid 1 (2%)
Submucosa, Amyloid Deposition 1 (2%)
Liver (49) (19) (49)
Basophilic Focus 1 (5%)
Cyst, Multiple 1 (5%)
Developmental Malformation 1 (2%)
Focal Cellular Change 2 (4%) 2 (4%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Multifocal 1 (5%) 2 (4%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Proliferation Connective Tissue 1 (5%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Fatty Change, Multifocal 1 (2%)
Serosa, Fibrosis 1 (2%)
Mesentery (2) (1)
Inflammation, Chronic 1 (50%)
Pancreas (49) (12) (49)
Cyst 1 (8%)
Fibrosis, Diffuse 1 (2%)
Salivary Glands (49) (10) (49)
Inflammation, Chronic 2 (4%) 4 (8%)
Stomach, Forestomach (50) (15) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05080-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperkeratosis 3 (6%) 1 (7%) 1 (2%)
Hyperplasia, Squamous 1 (7%)
Mineralization, Focal 1 (2%)
Ulcer 2 (13%) 2 (4%)
Stomach, Glandular (50) (15) (49)
Atrophy 1 (2%)
Atrophy, Diffuse 1 (2%)
Cyst 1 (2%)
Dysplasia, Focal 1 (2%)
Necrosis, Multifocal 1 (2%)
Ulcer, Multiple 1 (7%)
Tooth (3) (3) (3)
Abscess 3 (100%)
Developmental Malformation 2 (67%)
Inflammation, Chronic, Focal 1 (33%)
Peridontal Tissue, Inflammation, Chronic 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (11) (50)
Atrium, Thrombosis 1 (2%)
Coronary Artery, Inflammation, Chronic, Focal 1 (2%)
Myocardium, Inflammation, Acute, Focal 1 (2%)
Myocardium, Inflammation, Chronic 2 (4%)
Valve, Inflammation, Chronic, Focal 1 (2%)
Valve, Pigmentation, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (11) (50)
Subcapsular, Hyperplasia 46 (94%) 10 (91%) 49 (98%)
Adrenal Gland, Cortex (49) (11) (49)
Accessory Adrenal Cortical Nodule 1 (2%)
Degeneration, Focal 2 (4%)
Hyperplasia, Focal 2 (4%)
Hypertrophy, Focal 1 (2%) 1 (2%)
Pituitary Gland (44) (9) (49)
Cyst 1 (2%)
Thyroid Gland (50) (10) (49)
Follicular Cell, Hyperplasia 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05080-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Penis (1) (2)
Inflammation, Necrotizing 1 (100%) 1 (50%)
Preputial Gland (8) (9) (8)
Cyst 2 (25%) 4 (44%) 5 (63%)
Cyst, Multiple 1 (13%)
Inflammation, Chronic 1 (13%) 1 (11%)
Inflammation, Suppurative 5 (63%) 3 (33%)
Prostate (45) (11) (44)
Inflammation, Suppurative 2 (4%)
Seminal Vesicle (47) (10) (44)
Dilatation 1 (2%) 1 (10%)
Hemorrhage, Diffuse 1 (2%)
Inflammation, Suppurative 2 (4%)
Testes (49) (11) (49)
Mineralization 2 (4%)
Bilateral, Atrophy 2 (4%)
Interstitial Cell, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (43) (15) (45)
Mesenteric, Hemorrhage, Acute 1 (7%)
Mesenteric, Hyperplasia 1 (2%)
Lymph Node, Bronchial (29) (7) (29)
Edema 1 (3%)
Hyperplasia, Lymphoid 1 (3%) 1 (3%)
Lymph Node, Mandibular (34) (9) (33)
Hyperplasia, Lymphoid 1 (3%) 1 (11%) 1 (3%)
Infiltration Cellular, Histiocyte 7 (21%) 1 (3%)
Spleen (49) (16) (49)
Atrophy 1 (6%) 2 (4%)
Hematopoietic Cell Proliferation 3 (6%) 2 (13%) 2 (4%)
Hyperplasia, Lymphoid 3 (6%)
Capsule, Fibrosis 1 (2%)
Thymus (30) (4) (31)
Cyst 3 (10%)
Mediastinum, Inflammation, Chronic 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05080-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (17) (50)
Inflammation, Chronic, Focal 1 (2%)
Dermis, Abscess 1 (2%)
Epidermis, Necrosis, Acute 1 (2%)
Hair Follicle, Atrophy 3 (6%) 5 (29%)
Prepuce, Inflammation, Suppurative 3 (6%)
Prepuce, Ulcer 3 (18%)
Sebaceous Gland, Hyperplasia 1 (6%)
Subcutaneous Tissue, Edema 1 (6%)
Subcutaneous Tissue, Hemorrhage, Acute 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (6%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%) 1 (6%)
Subcutaneous Tissue, Inflammation,
Suppurative 3 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (11) (50)
Cerebrum, Mineralization 1 (2%)
Hypothalamus, Atrophy 1 (2%)
Thalamus, Atrophy 1 (2%)
Thalamus, Hemorrhage, Acute, Focal 1 (2%)
Thalamus, Mineralization 29 (58%) 3 (27%) 8 (16%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (19) (50)
Congestion, Diffuse 1 (2%)
Granuloma 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (5%) 2 (4%)
Inflammation, Chronic, Multifocal 17 (34%) 3 (16%) 21 (42%)
Inflammation, Suppurative 1 (2%)
Alveolus, Adenomatosis, Focal 2 (4%) 1 (5%)
Alveolus, Hyperplasia, Focal 2 (4%)
Glands, Ectasia 8 (16%)
Glands, Inflammation, Suppurative 1 (2%)
Interstitium, Inflammation, Acute 3 (6%)
Nose (50) (50) (50)
Glands, Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05080-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 20:33:17
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Glands, Hyperplasia 8 (16%) 47 (94%) 48 (96%)
Mucosa, Inflammation, Suppurative 2 (4%) 48 (96%) 47 (94%)
Olfactory Epithelium, Metaplasia 4 (8%) 49 (98%) 50 (100%)
Respiratory Epithelium, Dysplasia 1 (2%) 3 (6%)
Respiratory Epithelium, Dysplasia, Focal 1 (2%)
Respiratory Epithelium, Hyperplasia 25 (50%) 40 (80%)
Respiratory Epithelium, Hyperplasia, Basal
Cell 1 (2%) 7 (14%)
Respiratory Epithelium, Metaplasia, Squamous 4 (8%) 8 (16%)
Respiratory Epithelium, Regeneration 46 (92%) 46 (92%)
Submucosa, Angiectasis 1 (2%) 2 (4%) 5 (10%)
Trachea (50) (10) (48)
Epithelium, Metaplasia, Squamous 1 (2%)
Glands, Dilatation 41 (82%) 27 (56%)
Mediastinum, Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (15) (49)
Inflammation, Chronic 39 (80%) 4 (27%) 30 (61%)
Inflammation, Suppurative 4 (8%) 1 (7%)
Capsule, Fibrosis 1 (7%)
Cortex, Cyst 2 (13%)
Cortex, Metaplasia, Osseous 1 (2%)
Medulla, Cyst 1 (7%)
Renal Tubule, Dilatation, Diffuse 1 (2%)
Renal Tubule, Regeneration 32 (65%) 3 (20%) 32 (65%)
Renal Tubule, Regeneration, Multifocal 2 (4%)
Urinary Bladder (49) (11) (49)
Calculus Micro Observation Only 1 (9%)
Inflammation, Chronic 2 (4%)
Inflammation, Chronic, Multifocal 2 (4%)
Inflammation, Suppurative 4 (8%) 1 (9%)
Transitional Epithelium, Hyperplasia 1 (9%)
Transitional Epithelium, Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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