TDMS Study 05080-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ALLYL GLYCIDYL ETHER DATE: 09/10/94
EXPERIMENT: 05080 TEST: 02 TIME: 20:42:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01ES38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56666
PATHOLOGIST: R. BUSCH CAS: 106-92-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ALLYL GLYCIDYL ETHER DATE: 09/10/94
EXPERIMENT: 05080 TEST: 02 TIME: 20:42:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56666
PATHOLOGIST: R. BUSCH CAS: 106-92-3
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest ALLYL GLYCIDYL ETHER DATE: 09/10/94
EXPERIMENT: 05080 TEST: 02 TIME: 20:42:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01ES38061 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 56666
PATHOLOGIST: R. BUSCH CAS: 106-92-3
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF ALLYL GLYCIDYL ETHER
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Nose Adenoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Liver Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
All Organs Histiocytic Sarcoma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 5/50 (10%) |
|ADJUSTED (b) | 10.5% 5.1% 0.0% | 0.0% 0.0% 11.9% |
|TERMINAL (d) | 4/38 (11%) 2/39 (5%) 0/46 (0%) | 0/33 (0%) 0/42 (0%) 4/41 (10%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) --- | --- --- 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.025N* P=0.324N P=0.042N* | P=0.009 ** (e) P=0.058 |
|INCIDENTAL TUMOR | P=0.025N* P=0.324N P=0.042N* | P=0.007 ** (e) P=0.039 * |
|LOGISTIC REGRESSION | P=0.025N* P=0.324N P=0.042N* | P=0.009 ** (e) P=0.052 |
|COCHRAN-ARMITAGE | P=0.037N* | P=0.006 ** |
|FISHER EXACT | P=0.339N P=0.059N | (e) P=0.028 * |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/49 (31%) 7/19 (37%) 5/49 (10%) | 1/50 (2%) 2/15 (13%) 2/50 (4%) |
|ADJUSTED (b) | 35.2% 64.3% 10.6% | 3.0% 28.6% 4.7% |
|TERMINAL (d) | 11/38 (29%) 5/8 (63%) 4/46 (9%) | 1/33 (3%) 2/7 (29%) 1/41 (2%) |
|FIRST INCIDENCE (DAYS) | 474 677 690 | 730 (T) 730 (T) 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004N** P=0.348 P=0.005N** | P=0.496 P=0.064 P=0.580 |
|INCIDENTAL TUMOR | P=0.021N* P=0.242 P=0.039N* | P=0.438 P=0.064 P=0.487 |
|LOGISTIC REGRESSION | P=0.010N** P=0.317 P=0.012N* | P=0.493 P=0.064 P=0.567 |
|COCHRAN-ARMITAGE | P=0.011N* | P=0.403 |
|FISHER EXACT | P=0.414 P=0.011N* | P=0.131 P=0.500 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/49 (20%) 4/19 (21%) 1/49 (2%) | 5/50 (10%) 3/15 (20%) 0/50 (0%) |
|ADJUSTED (b) | 22.8% 28.1% 2.2% | 14.2% 30.1% 0.0% |
|TERMINAL (d) | 5/38 (13%) 2/8 (25%) 1/46 (2%) | 4/33 (12%) 2/7 (29%) 0/41 (0%) |
|FIRST INCIDENCE (DAYS) | 608 579 729 (T) | 642 548 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003N** P=0.445N P=0.003N** | P=0.021N* P=0.355 P=0.021N* |
|INCIDENTAL TUMOR | P=0.011N* P=0.306N P=0.037N* | P=0.030N* P=0.258 P=0.027N* |
|LOGISTIC REGRESSION | P=0.005N** P=0.604 P=0.005N** | P=0.035N* P=0.241 P=0.028N* |
|COCHRAN-ARMITAGE | P=0.005N** | P=0.038N* |
|FISHER EXACT | P=0.597 P=0.004N** | P=0.266 P=0.028N* |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/49 (47%) 11/19 (58%) 6/49 (12%) | 6/50 (12%) 5/15 (33%) 2/50 (4%) |
|ADJUSTED (b) | 48.8% 88.6% 12.7% | 17.2% 58.0% 4.7% |
|TERMINAL (d) | 14/38 (37%) 7/8 (88%) 5/46 (11%) | 5/33 (15%) 4/7 (57%) 1/41 (2%) |
|FIRST INCIDENCE (DAYS) | 474 579 690 | 642 548 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.446 P<0.001N** | P=0.072N P=0.063 P=0.082N |
|INCIDENTAL TUMOR | P=0.001N** P=0.447 P=0.005N** | P=0.108N P=0.035 * P=0.125N |
|LOGISTIC REGRESSION | P<0.001N** P=0.231 P=0.003N** | P=0.113N P=0.036 * P=0.107N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.135N |
|FISHER EXACT | P=0.295 P<0.001N** | P=0.067 P=0.134N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/49 (47%) 11/19 (58%) 6/49 (12%) | 6/50 (12%) 5/15 (33%) 2/50 (4%) |
|ADJUSTED (b) | 48.8% 88.6% 12.7% | 17.2% 58.0% 4.7% |
|TERMINAL (d) | 14/38 (37%) 7/8 (88%) 5/46 (11%) | 5/33 (15%) 4/7 (57%) 1/41 (2%) |
|FIRST INCIDENCE (DAYS) | 474 579 690 | 642 548 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.446 P<0.001N** | P=0.072N P=0.063 P=0.082N |
|INCIDENTAL TUMOR | P=0.001N** P=0.447 P=0.005N** | P=0.108N P=0.035 * P=0.125N |
|LOGISTIC REGRESSION | P<0.001N** P=0.231 P=0.003N** | P=0.113N P=0.036 * P=0.107N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.135N |
|FISHER EXACT | P=0.295 P<0.001N** | P=0.067 P=0.134N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 2/19 (11%) 6/50 (12%) | 0/50 (0%) 1/9 (11%) 3/50 (6%) |
|ADJUSTED (b) | 17.8% 14.6% 13.0% | 0.0% 2.1% 7.3% |
|TERMINAL (d) | 6/38 (16%) 1/8 (13%) 6/46 (13%) | 0/33 (0%) 0/1 (0%) 3/41 (7%) |
|FIRST INCIDENCE (DAYS) | 667 722 729 (T) | --- 604 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.304N P=0.585N P=0.360N | P=0.124 P=0.518 P=0.162 |
|INCIDENTAL TUMOR | P=0.381N P=0.628N P=0.423N | P=0.105 P=0.398 P=0.162 |
|LOGISTIC REGRESSION | P=0.359N P=0.670N P=0.439N | P=0.098 P=0.195 P=0.162 |
|COCHRAN-ARMITAGE | P=0.440N | P=0.092 |
|FISHER EXACT | P=0.526N P=0.500N | P=0.153 P=0.121 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 7/19 (37%) 3/50 (6%) | 0/50 (0%) 0/9 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 75.6% 6.5% | 0.0% 0.0% 2.4% |
|TERMINAL (d) | 0/38 (0%) 6/8 (75%) 3/46 (7%) | 0/33 (0%) 0/1 (0%) 1/41 (2%) |
|FIRST INCIDENCE (DAYS) | --- 667 729 (T) | --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.278 P<0.001 ** P=0.157 | P=0.345 (e) P=0.543 |
|INCIDENTAL TUMOR | P=0.236 P<0.001 ** P=0.157 | P=0.345 (e) P=0.543 |
|LOGISTIC REGRESSION | P=0.226 P<0.001 ** P=0.157 | P=0.345 (e) P=0.543 |
|COCHRAN-ARMITAGE | P=0.184 | P=0.300 |
|FISHER EXACT | P<0.001 ** P=0.121 | (e) P=0.500 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 9/19 (47%) 9/50 (18%) | 0/50 (0%) 1/9 (11%) 4/50 (8%) |
|ADJUSTED (b) | 17.8% 88.1% 19.6% | 0.0% 2.1% 9.8% |
|TERMINAL (d) | 6/38 (16%) 7/8 (88%) 9/46 (20%) | 0/33 (0%) 0/1 (0%) 4/41 (10%) |
|FIRST INCIDENCE (DAYS) | 667 667 729 (T) | --- 604 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.541N P<0.001 ** P=0.554 | P=0.073 P=0.518 P=0.094 |
|INCIDENTAL TUMOR | P=0.450 P<0.001 ** P=0.492 | P=0.061 P=0.398 P=0.094 |
|LOGISTIC REGRESSION | P=0.460 P<0.001 ** P=0.469 | P=0.053 P=0.195 P=0.094 |
|COCHRAN-ARMITAGE | P=0.356 | P=0.047 * |
|FISHER EXACT | P=0.006 ** P=0.393 | P=0.153 P=0.059 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 4/50 (8%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 10.4% 2.4% 4.9% |
|TERMINAL (d) | 0/38 (0%) 0/39 (0%) 0/46 (0%) | 1/33 (3%) 1/42 (2%) 2/41 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 534 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.181N P=0.136N P=0.263N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.383N P=0.323N P=0.541N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.234N P=0.180N P=0.332N |
|COCHRAN-ARMITAGE | (e) | P=0.238N |
|FISHER EXACT | (e) (e) | P=0.181N P=0.339N |
|=================================================================================================================================|
| |
|Nose |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 3/50 (6%) | 0/49 (0%) 0/49 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 6.3% | 0.0% 0.0% 2.4% |
|TERMINAL (d) | 0/38 (0%) 0/39 (0%) 2/46 (4%) | 0/33 (0%) 0/42 (0%) 1/41 (2%) |
|FIRST INCIDENCE (DAYS) | --- --- 690 | --- --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.052 (e) P=0.157 | P=0.294 (e) P=0.543 |
|INCIDENTAL TUMOR | P=0.025 * (e) P=0.080 | P=0.294 (e) P=0.543 |
|LOGISTIC REGRESSION | P=0.038 * (e) P=0.124 | P=0.294 (e) P=0.543 |
|COCHRAN-ARMITAGE | P=0.037 * | P=0.273 |
|FISHER EXACT | (e) P=0.121 | (e) P=0.505 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/44 (0%) 0/9 (0%) 0/49 (0%) | 12/44 (27%) 8/17 (47%) 2/45 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 36.1% 68.1% 5.4% |
|TERMINAL (d) | 0/34 (0%) 0/0 0/45 (0%) | 11/32 (34%) 6/9 (67%) 2/37 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 696 659 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.002N** P=0.085 P=0.002N** |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.004N** P=0.032 * P=0.002N** |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.003N** P=0.033 * P=0.002N** |
|COCHRAN-ARMITAGE | (e) | P=0.006N** |
|FISHER EXACT | (e) (e) | P=0.121 P=0.003N** |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/44 (0%) 0/9 (0%) 0/49 (0%) | 13/44 (30%) 8/17 (47%) 2/45 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 39.2% 68.1% 5.4% |
|TERMINAL (d) | 0/34 (0%) 0/0 0/45 (0%) | 12/32 (38%) 6/9 (67%) 2/37 (5%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 696 659 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.001N** P=0.110 P<0.001N** |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.002N** P=0.045 * P<0.001N** |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.002N** P=0.047 * P<0.001N** |
|COCHRAN-ARMITAGE | (e) | P=0.003N** |
|FISHER EXACT | (e) (e) | P=0.161 P=0.001N** |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/44 (2%) 0/9 (0%) 1/49 (2%) | 1/44 (2%) 0/17 (0%) 2/45 (4%) |
|ADJUSTED (b) | 2.9% 0.0% 2.2% | 3.1% 0.0% 4.4% |
|TERMINAL (d) | 1/34 (3%) 0/0 1/45 (2%) | 1/32 (3%) 0/9 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 729 (T) | 730 (T) --- 620 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.563N (e) P=0.698N | P=0.405 P=0.751N P=0.544 |
|INCIDENTAL TUMOR | P=0.563N (e) P=0.698N | P=0.348 P=0.751N P=0.470 |
|LOGISTIC REGRESSION | P=0.563N (e) P=0.698N | P=0.372 P=0.751N P=0.491 |
|COCHRAN-ARMITAGE | P=0.618N | P=0.382 |
|FISHER EXACT | P=0.830N P=0.725N | P=0.721N P=0.509 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/10 (0%) 3/49 (6%) | 2/50 (4%) 0/10 (0%) 3/50 (6%) |
|ADJUSTED (b) | 2.6% 0.0% 6.5% | 5.3% 0.0% 7.3% |
|TERMINAL (d) | 1/38 (3%) 0/0 2/45 (4%) | 1/33 (3%) 0/2 (0%) 3/41 (7%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 701 | 638 --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.263 (e) P=0.366 | P=0.488 P=0.447N P=0.582 |
|INCIDENTAL TUMOR | P=0.198 (e) P=0.257 | P=0.450 P=0.550N P=0.533 |
|LOGISTIC REGRESSION | P=0.234 (e) P=0.316 | P=0.436 P=0.658N P=0.525 |
|COCHRAN-ARMITAGE | P=0.206 | P=0.405 |
|FISHER EXACT | P=0.833N P=0.301 | P=0.692N P=0.500 |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/10 (0%) 3/49 (6%) | 2/50 (4%) 1/10 (10%) 3/50 (6%) |
|ADJUSTED (b) | 2.6% 0.0% 6.5% | 5.3% 50.0% 7.3% |
|TERMINAL (d) | 1/38 (3%) 0/0 2/45 (4%) | 1/33 (3%) 1/2 (50%) 3/41 (7%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 701 | 638 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.263 (e) P=0.366 | P=0.507 P=0.587 P=0.582 |
|INCIDENTAL TUMOR | P=0.198 (e) P=0.257 | P=0.473 P=0.493 P=0.533 |
|LOGISTIC REGRESSION | P=0.234 (e) P=0.316 | P=0.453 P=0.435 P=0.525 |
|COCHRAN-ARMITAGE | P=0.206 | P=0.413 |
|FISHER EXACT | P=0.833N P=0.301 | P=0.427 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.6% 0.0% 2.1% | 5.5% 0.0% 0.0% |
|TERMINAL (d) | 1/38 (3%) 0/39 (0%) 0/46 (0%) | 1/33 (3%) 0/42 (0%) 0/41 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 690 | 688 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.628N P=0.495N P=0.721N | P=0.078N P=0.203N P=0.201N |
|INCIDENTAL TUMOR | P=0.593 P=0.495N P=0.674 | P=0.124N P=0.297N P=0.273N |
|LOGISTIC REGRESSION | P=0.666N P=0.495N P=0.761N | P=0.090N P=0.225N P=0.226N |
|COCHRAN-ARMITAGE | P=0.669N | P=0.095N |
|FISHER EXACT | P=0.500N P=0.753N | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/50 (4%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 2.6% 2.6% 4.2% | 5.5% 0.0% 2.3% |
|TERMINAL (d) | 1/38 (3%) 1/39 (3%) 1/46 (2%) | 1/33 (3%) 0/42 (0%) 0/41 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 690 | 688 --- 727 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.439 P=0.756N P=0.562 | P=0.307N P=0.203N P=0.428N |
|INCIDENTAL TUMOR | P=0.350 P=0.756N P=0.425 | P=0.460N P=0.297N P=0.606N |
|LOGISTIC REGRESSION | P=0.392 P=0.756N P=0.509 | P=0.343N P=0.225N P=0.476N |
|COCHRAN-ARMITAGE | P=0.378 | P=0.360N |
|FISHER EXACT | P=0.753N P=0.500 | P=0.247N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 8.0% 0.0% 0.0% |
|TERMINAL (d) | 0/38 (0%) 0/39 (0%) 0/46 (0%) | 1/33 (3%) 0/42 (0%) 0/41 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 638 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.028N* P=0.097N P=0.098N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.065N P=0.188N P=0.174N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.036N* P=0.116N P=0.116N |
|COCHRAN-ARMITAGE | (e) | P=0.037N* |
|FISHER EXACT | (e) (e) | P=0.121N P=0.121N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 8/50 (16%) 4/50 (8%) | 25/50 (50%) 9/50 (18%) 16/50 (32%) |
|ADJUSTED (b) | 7.9% 19.0% 8.7% | 60.8% 20.3% 37.1% |
|TERMINAL (d) | 3/38 (8%) 6/39 (15%) 4/46 (9%) | 17/33 (52%) 7/42 (17%) 14/41 (34%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 570 729 (T) | 638 604 688 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.549 P=0.112 P=0.604 | P=0.009N** P<0.001N** P=0.011N* |
|INCIDENTAL TUMOR | P=0.444 P=0.138 P=0.604 | P=0.029N* P<0.001N** P=0.034N* |
|LOGISTIC REGRESSION | P=0.445 P=0.102 P=0.604 | P=0.017N* P<0.001N** P=0.021N* |
|COCHRAN-ARMITAGE | P=0.434 | P=0.036N* |
|FISHER EXACT | P=0.100 P=0.500 | P<0.001N** P=0.052N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 8/50 (16%) 4/50 (8%) | 22/50 (44%) 9/50 (18%) 16/50 (32%) |
|ADJUSTED (b) | 7.9% 19.0% 8.7% | 56.0% 20.3% 37.1% |
|TERMINAL (d) | 3/38 (8%) 6/39 (15%) 4/46 (9%) | 16/33 (48%) 7/42 (17%) 14/41 (34%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 570 729 (T) | 642 604 688 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.549 P=0.112 P=0.604 | P=0.036N* P<0.001N** P=0.041N* |
|INCIDENTAL TUMOR | P=0.444 P=0.138 P=0.604 | P=0.093N P=0.004N** P=0.098N |
|LOGISTIC REGRESSION | P=0.445 P=0.102 P=0.604 | P=0.068N P=0.002N** P=0.074N |
|COCHRAN-ARMITAGE | P=0.434 | P=0.118N |
|FISHER EXACT | P=0.100 P=0.500 | P=0.004N** P=0.151N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 10/50 (20%) 18/50 (36%) | 14/50 (28%) 12/50 (24%) 15/50 (30%) |
|ADJUSTED (b) | 59.2% 24.3% 37.5% | 38.3% 26.5% 34.0% |
|TERMINAL (d) | 21/38 (55%) 8/39 (21%) 16/46 (35%) | 11/33 (33%) 9/42 (21%) 12/41 (29%) |
|FIRST INCIDENCE (DAYS) | 474 677 690 | 638 604 620 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.025N* P=0.002N** P=0.029N* | P=0.405N P=0.206N P=0.423N |
|INCIDENTAL TUMOR | P=0.091N P=0.002N** P=0.122N | P=0.489 P=0.381N P=0.579 |
|LOGISTIC REGRESSION | P=0.064N P=0.001N** P=0.089N | P=0.532 P=0.337N P=0.570N |
|COCHRAN-ARMITAGE | P=0.087N | P=0.455 |
|FISHER EXACT | P=0.002N** P=0.113N | P=0.410N P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 18/50 (36%) 10/50 (20%) | 30/50 (60%) 15/50 (30%) 21/50 (42%) |
|ADJUSTED (b) | 29.1% 40.2% 20.8% | 69.6% 33.1% 47.6% |
|TERMINAL (d) | 7/38 (18%) 13/39 (33%) 8/46 (17%) | 20/33 (61%) 12/42 (29%) 18/41 (44%) |
|FIRST INCIDENCE (DAYS) | 608 570 690 | 534 548 602 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.167N P=0.234 P=0.198N | P=0.009N** P<0.001N** P=0.010N* |
|INCIDENTAL TUMOR | P=0.515N P=0.293 P=0.492 | P=0.044N* P=0.003N** P=0.049N* |
|LOGISTIC REGRESSION | P=0.538N P=0.215 P=0.309N | P=0.025N* P=0.001N** P=0.025N* |
|COCHRAN-ARMITAGE | P=0.287N | P=0.043N* |
|FISHER EXACT | P=0.194 P=0.318N | P=0.002N** P=0.055N |
|=================================================================================================================================|
DATE: 09/10/94 EXPERIMENT: 05080 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ALLYL GLYCIDYL ETHER
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 5 PPM 10 PPM | CONTROL 5 PPM 10 PPM |
| | MALE MALE MALE | FEMALE FEMALE FEMALE |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 32/50 (64%) 26/50 (52%) 21/50 (42%) | 35/50 (70%) 21/50 (42%) 31/50 (62%) |
|ADJUSTED (b) | 68.0% 56.2% 43.7% | 81.3% 44.6% 67.3% |
|TERMINAL (d) | 23/38 (61%) 19/39 (49%) 19/46 (41%) | 25/33 (76%) 16/42 (38%) 26/41 (63%) |
|FIRST INCIDENCE (DAYS) | 474 570 690 | 534 548 602 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005N** P=0.170N P=0.005N** | P=0.054N P<0.001N** P=0.043N* |
|INCIDENTAL TUMOR | P=0.051N P=0.121N P=0.082N | P=0.224N P=0.004N** P=0.195N |
|LOGISTIC REGRESSION | P=0.015N* P=0.151N P=0.018N* | P=0.151N P=0.001N** P=0.132N |
|COCHRAN-ARMITAGE | P=0.018N* | P=0.239N |
|FISHER EXACT | P=0.156N P=0.022N* | P=0.004N** P=0.263N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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