TDMS Study 05080-02 Pathology Tables
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
Facility: Battelle Northwest
Chemical CAS #: 106-92-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| 3|
| 2| 2| 7| 6| 2| 2| 8| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic, Focal | |
Inflammation, Chronic, Multifocal | 1 |
Leukocytosis | |
Hepatocyte, Cytomegaly | |
__________________________________________________________________________|
Mesentery | + + + |
Hyperplasia, Lymphoid | 4 |
Inflammation, Suppurative | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 |
Hyperplasia, Lymphoid | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic, Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 2 |
Hyperkeratosis | |
Hyperplasia | 3 |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic | |
Peridontal Tissue, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| 3|
| 2| 2| 7| 6| 2| 2| 8| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Inflammation, Chronic | |
Atrium, Inflammation, Focal, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 3 2 2 2 2 2 2 2 2 2 2 1 2 2 3 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cyst | X|
Degeneration | 2 1 1 1 2 2 1 2 1 1 1 2 1 2 2 1 1 1|
Fibrosis | 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1|
Hematopoietic Cell Proliferation | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + M M M + M + + M + + M + + M M M M + + M|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 1 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Degeneration | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abscess | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X|
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 3 2 3 2 2 2 2 2 1 3 2 2 2 3 2 2 2 2 2 2 2|
Endometrium, Inflammation, Acute | 3 |
Endometrium, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| 3|
| 2| 2| 7| 6| 2| 2| 8| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Suppurative | 2 |
Endometrium, Necrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Myelofibrosis | 2 2 2 3 2 2 2 2 2 3 2 3 2 2 1 2 2 2 3 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + + + + + +|
Mesenteric, Hyperplasia, Lymphoid | 4 |
Renal, Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + M + M + M + + M + + + M + + + M + + M +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + M + + + M + + + M + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 4 2 4 |
Inflammation, Suppurative | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 3 4 3 2 4 |
__________________________________________________________________________|
Thymus | + M + M + + + + M M M + + + + M M + M + + + + + +|
Atrophy | |
Hyperplasia, Lymphoid | 4 |
Inflammation, Necrotizing | |
Mediastinum, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + M + + + + + + + + + + M + + + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Hair Follicle, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Atrophy | 4 3 2 2|
Lateral Ventricle, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| 3|
| 2| 2| 7| 6| 2| 2| 8| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Multifocal | 2 2 2 1 2 2 1 2 |
Leukocytosis | |
Bronchiole, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 2|
Mucosa, Inflammation, Acute | 2 |
Mucosa, Inflammation | 1 |
Mucosa, Inflammation, Suppurative | 1 1 1 |
Olfactory Epithelium, Metaplasia | 1 1 1 |
Respiratory Epithelium, Regeneration | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Suppurative | |
Mediastinum, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | M + |
Inflammation, Necrotizing | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 4 |
Inflammation, Chronic | 1 2 1 |
Inflammation, Suppurative | |
Cortex, Infarct | |
Renal Tubule, Regeneration, Focal | |
Renal Tubule, Regeneration | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + I + +|
Hyperplasia, Lymphoid | 4 4 |
Inflammation, Chronic | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 8| 2| 3| 9| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 4| 3| 8| 3| |
| 1| 3| 2| 3| 2| 8| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2| 2| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M + + + + M + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | A A + A + A I + + + + + + + + + + + + + + + + + +| 45 |
Fibrosis | | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + A + + + + + + + + + + + + M + M + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small | A + + A + A + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + I + A + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + A + A + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + A + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 | 2 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Inflammation, Chronic, Multifocal | 1 2 1 | 4 1.3|
Leukocytosis | X | 1 |
Hepatocyte, Cytomegaly | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + +| 13 |
Hyperplasia, Lymphoid | 4 | 2 4.0|
Inflammation, Suppurative | 3 3 | 2 3.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 3 2.7|
Hyperplasia, Lymphoid | 4 4 | 2 4.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Chronic, Multifocal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma | | 1 2.0|
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
Hyperplasia, Squamous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 8| 2| 3| 9| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 4| 3| 8| 3| |
| 1| 3| 2| 3| 2| 8| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2| 2| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + | 3 |
Peridontal Tissue, Inflammation, | | |
Chronic | 4 | 1 4.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Atrium, Inflammation, Focal, | | |
Suppurative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | A + + A + + + + + + + + + + + + + + M + + + + + +| 47 |
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1| 42 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | A + + A + + + + + + + + + + + + + + M + + + + + +| 47 |
Accessory Adrenal Cortical Nodule | X | 2 |
Cyst | | 1 |
Degeneration | 1 1 2 2 1 2 2 1 1 2 2 1 1 3 2 2 1 2 1| 37 1.5|
Fibrosis | 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 2 1| 36 1.1|
Hematopoietic Cell Proliferation | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | A + + A + + + + + + + + + + + + + + M + + + + + +| 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M M M M + M + + M M + M + + + + + M| 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + M + M I + + +| 44 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 2 3 2 2 2 2 2 2 2 2| 15 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | | 1 2.0|
Follicle, Degeneration | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + + | 5 |
Abscess | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 8| 2| 3| 9| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 4| 3| 8| 3| |
| 1| 3| 2| 3| 2| 8| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2| 2| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X X X X X X X| 14 |
Inflammation, Suppurative | 4 4 4 4 | 4 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | 1 2 2 3 2 1 1 2 1 2 2 2 2 3 | 36 2.0|
Endometrium, Inflammation, Acute | | 1 3.0|
Endometrium, Inflammation, | | |
Suppurative | 3 3 | 3 2.7|
Endometrium, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Leukocytosis | X | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
Myelofibrosis | 2 2 2 2 2 3 3 1 2 2 2 1 2 2 2 2| 36 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Mesenteric, Hyperplasia, Lymphoid | | 1 4.0|
Renal, Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + M + M + M + + + +| 38 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + M + + + + + M + + M + + + + + +| 42 |
Cyst | X | 1 |
Hyperplasia, Lymphoid | 4 4 2 4 4 | 8 3.5|
Inflammation, Suppurative | 3 | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 4 3 3 | 6 3.2|
Hyperplasia, Lymphoid | 4 4 4 | 8 3.5|
__________________________________________________________________________|____________|
Thymus | + M + M + + + + M + M + M + + + M + + M + + + M +| 34 |
Atrophy | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Necrotizing | 3 | 1 3.0|
Mediastinum, Inflammation, | | |
Suppurative | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 8| 2| 3| 9| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 4| 3| 8| 3| |
| 1| 3| 2| 3| 2| 8| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2| 2| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + M + + M + + M M + + + M M + + M M + M + M| 35 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 4 | 1 4.0|
Hair Follicle, Atrophy | 3 3 3 3 | 5 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypothalamus, Atrophy | 2 | 5 2.6|
Lateral Ventricle, Dilatation | | 1 3.0|
Thalamus, Mineralization | 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + I + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 4 4 | 3 4.0|
Inflammation, Acute, Focal | 2 | 1 2.0|
Inflammation, Chronic, Multifocal | 2 1 2 3 2 2 2 2 2 | 17 1.9|
Leukocytosis | 3 3 | 2 3.0|
Bronchiole, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Glands, Hyperplasia | 2 1 2 1 1 1 2 1 1 1 1| 32 1.2|
Mucosa, Inflammation, Acute | | 1 2.0|
Mucosa, Inflammation | | 1 1.0|
Mucosa, Inflammation, Suppurative | 2 2 1 2 3 | 8 1.6|
Olfactory Epithelium, Metaplasia | 2 2 2 1 | 7 1.4|
Respiratory Epithelium, Regeneration | 3 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Inflammation, Suppurative | 1 | 1 1.0|
Mediastinum, Inflammation, | | |
Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 8| 2| 3| 9| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 4| 3| 8| 3| |
| 1| 3| 2| 3| 2| 8| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2| 2| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Inflammation, Necrotizing | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 4 4 | 4 4.0|
Inflammation, Chronic | 2 2 2 2 2 2 1| 10 1.7|
Inflammation, Suppurative | 2 2 | 2 2.0|
Cortex, Infarct | 2 | 1 2.0|
Renal Tubule, Regeneration, Focal | 2 | 1 2.0|
Renal Tubule, Regeneration | 1 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + + + + + I + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 4 | 3 4.0|
Inflammation, Chronic | 2 2 2 2 2 2 1 | 10 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 3| 3| 5| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
__________________________________________________________________________|
Gallbladder | A + + + A |
__________________________________________________________________________|
Intestine Large | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + M M + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + |
__________________________________________________________________________|
Intestine Small | A + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | A M + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + +|
Basophilic Focus | |
Cyst | X |
Hematopoietic Cell Proliferation | 1 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + M + + + |
Atrophy | |
Cyst | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + |
Inflammation, Chronic, Multifocal | 2 |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Hyperkeratosis | |
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
Atrophy, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + |
__________________________________________________________________________|
Heart | + + + + + |
Myocardium, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | M + + + + + |
Subcapsular, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | M + + + + + |
Degeneration | 2 2 2 |
Fibrosis | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M I + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 3| 3| 5| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M M M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M + + + + + + + +|
Cyst | X X X X X X|
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Endometrium, Hyperplasia, Cystic | 3 3 2 2 2 2 2 2 2 4 2 2 2 2 2 |
Endometrium, Inflammation, | |
Suppurative | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Myelofibrosis | 2 2 2 2 1 3 2 2 3 3 3 2 3 3 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + +|
Hair Follicle, Atrophy | 2 3 3 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Back, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
Thalamus, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|
| 3| 3| 5| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + |
__________________________________________________________________________|
Lung | + + + + + |
Inflammation, Chronic, Multifocal | 2 |
Leukocytosis | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia | 3 3 1 2 3 3 3 3 2 3 2 2 3 1 3 3 3 3 2 3 3 3 3|
Glands, Inflammation | 3 |
Glands, Regeneration | |
Mucosa, Inflammation, Suppurative | 2 2 1 1 1 1 2 1 1 1 2 2 2 1 1 2 2 2 2 1 2 1 2 1|
Olfactory Epithelium, Metaplasia | 3 3 1 1 2 2 3 1 2 2 3 3 2 2 3 2 3 3 3 2 3 3 2 2|
Respiratory Epithelium, Hyperplasia, | |
Basal Cell | 2 1 |
Respiratory Epithelium, Hyperplasia | 1 1 2 1 2 2 1 1 2 2 2 2 1 2 1 1 1 1 1 2 1 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 |
Respiratory Epithelium, Regeneration | 2 3 3 3 2 2 2 2 2 3 3 2 3 3 3 2 1 2 3 1 2 2 3|
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 2 |
Cortex, Cyst | |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 9 |
__________________________________________________________________________|____________|
Gallbladder | + + + A | 6 |
__________________________________________________________________________|____________|
Intestine Large | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + M | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + + + A | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A | 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A | 7 |
__________________________________________________________________________|____________|
Liver | + + + + + | 15 |
Basophilic Focus | 3 | 1 3.0|
Cyst | X | 2 |
Hematopoietic Cell Proliferation | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 4 |
Inflammation, Chronic | 3 | 1 3.0|
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 10 |
Atrophy | 3 | 1 3.0|
Cyst | X | 1 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 9 |
Inflammation, Chronic, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + | 12 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 12 |
Hyperkeratosis | 3 | 1 3.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A | 10 |
Atrophy, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 9 |
__________________________________________________________________________|____________|
Heart | + + + + | 9 |
Myocardium, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + | 9 |
Subcapsular, Hyperplasia | 2 2 2 1 | 8 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + A | 8 |
Degeneration | 2 2 | 5 2.0|
Fibrosis | 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + A | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 17 |
Pars Distalis, Hyperplasia | 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 10 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 19 |
Cyst | X X X X | 10 |
Inflammation, Suppurative | 2 2 | 3 2.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 24 |
Endometrium, Hyperplasia, Cystic | 3 2 2 2 1 3 1 | 22 2.2|
Endometrium, Inflammation, | | |
Suppurative | | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 9 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + | 35 |
Myelofibrosis | 1 1 3 3 2 3 2 2 3 2 2 3 3 3 2 | 32 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + +| 11 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + +| 7 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M +| 6 |
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + +| 18 |
Hematopoietic Cell Proliferation | | 3 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + +| 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hair Follicle, Atrophy | 3 2 3 3| 8 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 9 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Back, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 9 |
Thalamus, Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 9 |
__________________________________________________________________________|____________|
Lung | + + + + | 9 |
Inflammation, Chronic, Multifocal | 2 | 2 2.0|
Leukocytosis | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Glands, Hyperplasia | 2 2 3 3 2 3 2 3 3 2 3 2 3 3 3 3 3 3 3 3 3 1 3| 46 2.6|
Glands, Inflammation | | 1 3.0|
Glands, Regeneration | 3 | 1 3.0|
Mucosa, Inflammation, Suppurative | 2 1 2 1 1 2 2 2 2 2 2 2 1 1 1 2 2 3 1 2 1 2 2 2| 48 1.6|
Olfactory Epithelium, Metaplasia | 3 1 3 1 1 3 3 2 3 2 2 3 1 2 2 3 3 3 2 3 2 3 2 3| 48 2.3|
Respiratory Epithelium, Hyperplasia, | | |
Basal Cell | | 2 1.5|
Respiratory Epithelium, Hyperplasia | 2 1 2 2 2 1 2 1 1 1 1 1 1 2 1 2 2| 39 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 1 1 2 2 2 2 | 9 1.8|
Respiratory Epithelium, Regeneration | 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 3 1 2| 47 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + | 9 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A +| 10 |
Inflammation, Chronic | 2 1 | 3 1.3|
Inflammation, Suppurative | | 1 2.0|
Cortex, Cyst | X | 1 |
Renal Tubule, Necrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 9 |
Inflammation, Chronic | 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 7| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + + + M M + + A + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Inflammation, Chronic, Multifocal | |
__________________________________________________________________________|
Mesentery | + + +|
Hyperplasia, Lymphoid | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic, Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 3 |
Hyperplasia | 1 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Tooth | +|
Peridontal Tissue, Inflammation, | |
Chronic | 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 7| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | |
Degeneration | 2 1 1 2 1 2 3 1 1 2 1 1 1 2 2 2 2 2 2 2 2 2 |
Fibrosis | 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + M M M M M M + M M M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 3 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | X X X X X X X X X |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
Capsule, Fibrosis | 3 |
Capsule, Inflammation, Chronic | 2 |
Capsule, Mineralization | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 2 3 2 3 2 2 3 2 2 2 2 2 2 |
Endometrium, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 3 2 3 3 2 4 2 2 1 3 3 2 1 2 2 2 3 2 2 2 2 1 1 2|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + M + + + + + + M + + + M + + + M + M + + +|
Hyperplasia, Lymphoid | 4 4 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M M + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 7| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + M + + + + M + M + + + + + + M + M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Atrophy | 2 |
Thalamus, Mineralization | 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Diffuse, | |
Histiocyte | 2 |
Inflammation, Chronic, Multifocal | 2 2 2 2 1 2 2 2 1 2 2 2 1 2 |
Leukocytosis | |
Alveolus, Granuloma | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Thrombosis | 2 |
Glands, Hyperplasia | 3 4 3 4 4 3 4 4 3 3 3 4 4 4 4 4 4 4 4 4 3 3 3 4 3|
Mucosa, Inflammation, Suppurative | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 1 2 1 1 1 1 1|
Olfactory Epithelium, Metaplasia | 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 2 3 3 3 2 3 3 3 3|
Respiratory Epithelium, Dysplasia | 1 |
Respiratory Epithelium, Hyperplasia, | |
Basal Cell | 3 1 2 |
Respiratory Epithelium, Hyperplasia | 1 2 2 2 2 2 2 2 2 2 1 2 2 3 2 2 3 2 2 2 1 1 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 2 2 3 |
Respiratory Epithelium, Regeneration | 1 2 2 1 1 2 2 2 2 2 1 2 3 3 3 2 3 2 2 2 2 3 2 2|
Submucosa, Angiectasis, Focal | 3 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Squamous | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 3|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 7| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic | 1 2 1 1 2 2 2 2 1 1 2 |
Metaplasia, Focal, Osseous | 2 2 |
Regeneration | |
Renal Tubule, Regeneration | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 4 4 |
Inflammation, Chronic | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| |
| 0| 0| 2| 0| 0| 0| 0| 3| 0| 0| 9| 0| 0| 0| 7| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + + + A M + + + + + A + + + + + + + + + +| 42 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + + + + M + + M + + + + + + + + M + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 4 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + A + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + A + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + M + + + + + + A + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 4 2 | 3 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + M + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Focal Cellular Change | 1 | 1 1.0|
Inflammation, Chronic, Multifocal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + +| 8 |
Hyperplasia, Lymphoid | 4 4 | 2 4.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Cyst | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 4 | 2 4.0|
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | | 2 3.0|
Hyperplasia | | 2 2.0|
Ulcer | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + + + A + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 | 2 2.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| |
| 0| 0| 2| 0| 0| 0| 0| 3| 0| 0| 9| 0| 0| 0| 7| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + I + + + I + + + + + + +| 48 |
Subcapsular, Hyperplasia | 2 2 2 2 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2| 46 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + I + + + I + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | X | 1 |
Degeneration | 2 1 1 2 2 2 2 2 2 2 2 2 2 2 1 1 1 2 | 40 1.7|
Fibrosis | 2 1 1 1 1 1 2 2 1 2 1 2 1 2 1 1 1 1 | 40 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + I + + + I + + + + + + +| 47 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + I + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M + + + + + + + M + + M M + M M M + + M +| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + A I + + I + + + M + + I + + + + + +| 45 |
Pars Distalis, Hyperplasia | 2 2 | 9 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Cyst | X X X X X X X X X| 18 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 4 2 | 2 3.0|
Capsule, Fibrosis | | 1 3.0|
Capsule, Inflammation, Chronic | | 1 2.0|
Capsule, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 3 1 2 2 2 2 1 2 2 2| 29 2.0|
Endometrium, Inflammation, | | |
Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + I + + + + I + +| 48 |
Myelofibrosis | 1 2 1 3 2 1 2 1 1 1 2 3 3 2 3 3 2 2 3 1 1| 45 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| |
| 0| 0| 2| 0| 0| 0| 0| 3| 0| 0| 9| 0| 0| 0| 7| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + M + + + A + + + + + + + + + + + + + + + + +| 48 |
Renal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M + + + M M + M + M M + + M + + + M + M + M| 37 |
Hyperplasia, Lymphoid | 4 4 2 4 | 5 3.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + A + + + + + + + M + + M + + + + + +| 40 |
Hyperplasia, Lymphoid | 4 4 4 4 2 | 8 3.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 | 4 2.8|
Hyperplasia, Lymphoid | 4 4 2 4 4 2 2 4 | 10 3.4|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + M + + + M + + + M + M + +| 42 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + M M + + + M + + + + + M M + + M M + + M| 30 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hair Follicle, Atrophy | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Fibrous Osteodystrophy | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypothalamus, Atrophy | | 1 2.0|
Thalamus, Mineralization | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 4 4 4 4 | 5 4.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | | 1 2.0|
Inflammation, Chronic, Multifocal | 1 1 2 1 1 1 2 2 2 1 | 24 1.6|
Leukocytosis | 2 | 1 2.0|
Alveolus, Granuloma | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| |
| 0| 0| 2| 0| 0| 0| 0| 3| 0| 0| 9| 0| 0| 0| 7| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Thrombosis | | 1 2.0|
Glands, Hyperplasia | 4 3 4 3 4 3 3 3 4 1 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 49 3.3|
Mucosa, Inflammation, Suppurative | 2 2 2 1 1 1 3 2 1 2 1 2 2 2 2 2 1 1 2 2 1 2 2 1 1| 49 1.7|
Olfactory Epithelium, Metaplasia | 3 3 3 2 3 3 3 3 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 49 2.9|
Respiratory Epithelium, Dysplasia | 2 1 | 3 1.3|
Respiratory Epithelium, Hyperplasia, | | |
Basal Cell | 1 2 1 2 | 7 1.7|
Respiratory Epithelium, Hyperplasia | 2 2 2 2 1 2 2 2 3 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2| 48 1.9|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 3 2 2 3 3 2 2 | 12 2.3|
Respiratory Epithelium, Regeneration | 2 2 3 1 2 2 2 3 3 1 3 3 2 3 2 2 2 1 2 2 2 2| 46 2.1|
Submucosa, Angiectasis, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Focal, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Chronic | 1 1 2 2 2 2 1 | 18 1.6|
Metaplasia, Focal, Osseous | | 2 2.0|
Regeneration | 2 | 1 2.0|
Renal Tubule, Regeneration | 1 | 5 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + A + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Lymphoid | 4 | 4 4.0|
Inflammation, Chronic | 3 2 1 | 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 1| 6| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 2| 2| 2| 2| 2| 2| 2| 3| 1| 7| 2| 2| 1| 1| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A A A + A + + + + + M + + + + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Suppurative | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + + + + + + A + + + + A|
Lymphoid Tissue, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + A + + + + A|
Hyperplasia, Lymphoid | |
Submucosa, Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A M + + + + + + + + + + A + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Focal Cellular Change | |
Necrosis, Coagulative | 3 |
Centrilobular, Fatty Change, | |
Multifocal | |
Serosa, Fibrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Diffuse | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 |
Mineralization, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 2 |
Atrophy | |
Cyst | |
Dysplasia, Focal | |
Necrosis, Multifocal | |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | X X |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 1| 6| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 2| 2| 2| 2| 2| 2| 2| 3| 1| 7| 2| 2| 1| 1| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic, Focal | |
Valve, Inflammation, Chronic, Focal | 1 |
Valve, Pigmentation, Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 1 3 1 1 1 1 1 2 2 1 1 2 2 2 1 2 1 1 1 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + M + M + M + I + + + + M + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Preputial Gland | + + + |
Cyst | |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hemorrhage, Diffuse | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Bilateral, Atrophy | |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 1| 6| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 2| 2| 2| 2| 2| 2| 2| 3| 1| 7| 2| 2| 1| 1| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | M + + + + I + + + + + + + + + + + + + + + M + + +|
Mesenteric, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M M + I + + + I + + M M M + + M + + + M + + M|
Edema | 4 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + M + + M + + + + + + M + M + + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 2 2 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Capsule, Fibrosis | 3 |
__________________________________________________________________________|
Thymus | + + M + M M I M + M + I M M + + + + + M + M + + I|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dermis, Abscess | |
Epidermis, Necrosis, Acute | 4 |
Hair Follicle, Atrophy | 3 3 2 |
Prepuce, Inflammation, Suppurative | 4 4 |
Subcutaneous Tissue, Hemorrhage, | |
Acute | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Atrophy | |
Thalamus, Hemorrhage, Acute, Focal | 2 |
Thalamus, Mineralization | 2 1 2 1 1 1 2 1 2 2 1 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 0| 1| 6| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 2| 2| 2| 2| 2| 2| 2| 3| 1| 7| 2| 2| 1| 1| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion, Diffuse | 2 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic, Multifocal | 2 2 1 1 1 1 1 1 |
Alveolus, Adenomatosis, Focal | 2 2 |
Alveolus, Hyperplasia, Focal | 2 1 |
Glands, Ectasia | 2 2 2 2 2 |
Glands, Inflammation, Suppurative | 2 |
Interstitium, Inflammation, Acute | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 3 |
Glands, Hyperplasia | 1 1 1 1 |
Mucosa, Inflammation, Suppurative | 2 |
Olfactory Epithelium, Metaplasia | 1 1 1 |
Submucosa, Angiectasis | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 1 2 2 1 1 2 1 1 2 2 2 1 2 2 2 2 2 2 2 2|
Mediastinum, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 |
Inflammation, Suppurative | 2 4 |
Cortex, Metaplasia, Osseous | 4 |
Renal Tubule, Dilatation, Diffuse | 2 |
Renal Tubule, Regeneration | 1 1 1 1 1 2 2 1 1 1 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 4 |
Inflammation, Suppurative | 3 |
Transitional Epithelium, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 0| 3| |
| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 5| 2| 2| 1| 2| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + + + + + + + + + + + + M + M +| 41 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + A + + A + + +| 45 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + A + + +| 47 |
Inflammation, Suppurative | 3 | 1 3.0|
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + A + + +| 47 |
Inflammation, Suppurative | 3 3 | 2 3.0|
Parasite Metazoan | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + A + + +| 45 |
Lymphoid Tissue, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + I + + + M + + + + + + + A + + A + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + A + + +| 45 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Submucosa, Amyloid Deposition | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + A + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Developmental Malformation | X | 1 |
Focal Cellular Change | X X | 2 |
Necrosis, Coagulative | | 1 3.0|
Centrilobular, Fatty Change, | | |
Multifocal | 2 | 1 2.0|
Serosa, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Fibrosis, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 | 2 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 3 2.0|
Mineralization, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Diffuse | | 1 2.0|
Atrophy | 3 | 1 3.0|
Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 0| 3| |
| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 5| 2| 2| 1| 2| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Dysplasia, Focal | 2 | 1 2.0|
Necrosis, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
Developmental Malformation | | 2 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | X | 1 |
Coronary Artery, Inflammation, | | |
Chronic, Focal | 2 | 1 2.0|
Valve, Inflammation, Chronic, Focal | | 1 1.0|
Valve, Pigmentation, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Subcapsular, Hyperplasia | 1 1 1 1 2 1 1 2 2 1 2 2 2 1 1 4 1 2 2 2 1 3 1 1| 46 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Degeneration, Focal | 2 | 2 2.0|
Hypertrophy, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + I + + + I + + + + + + + + + + + + A + I +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + M M + M + M M + + M M M M + + M M + M M| 25 |
__________________________________________________________________________|____________|
Pituitary Gland | M M + + + + M + + + + + + M + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 1 | 4 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 8 |
Cyst | X X | 2 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 4 4 4 | 5 3.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 0| 3| |
| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 5| 2| 2| 1| 2| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + A + + +| 45 |
Inflammation, Suppurative | 3 | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Dilatation | | 1 4.0|
Hemorrhage, Diffuse | 3 | 1 3.0|
Inflammation, Suppurative | 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Mineralization | 2 1 | 2 1.5|
Bilateral, Atrophy | 2 3 | 2 2.5|
Interstitial Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + M + + + + + + M + + + + + + + + M + A + + +| 43 |
Mesenteric, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + + + + + M M M M + + + M + + M + M + M +| 29 |
Edema | | 1 4.0|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + M M + M + + + + + + + + M M A M + +| 34 |
Hyperplasia, Lymphoid | 4| 1 4.0|
Infiltration Cellular, Histiocyte | 2 2 | 7 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Capsule, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M M + + + + + M + + + + M + M + + + M + + M + + M| 30 |
Cyst | X X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M M M M M M M M + M M M M M M M M M M M M M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dermis, Abscess | 2 | 1 2.0|
Epidermis, Necrosis, Acute | | 1 4.0|
Hair Follicle, Atrophy | | 3 2.7|
Prepuce, Inflammation, Suppurative | 3 | 3 3.7|
Subcutaneous Tissue, Hemorrhage, | | |
Acute | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 0| 3| |
| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 5| 2| 2| 1| 2| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thalamus, Atrophy | 4 | 1 4.0|
Thalamus, Hemorrhage, Acute, Focal | | 1 2.0|
Thalamus, Mineralization | 2 2 2 2 2 2 2 2 2 1 1 2 1 1 2 2| 29 1.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion, Diffuse | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 2 1.0|
Inflammation, Chronic, Multifocal | 2 1 2 1 2 2 1 1 1 | 17 1.4|
Alveolus, Adenomatosis, Focal | | 2 2.0|
Alveolus, Hyperplasia, Focal | | 2 1.5|
Glands, Ectasia | 3 2 2 | 8 2.1|
Glands, Inflammation, Suppurative | | 1 2.0|
Interstitium, Inflammation, Acute | 3 1 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Dilatation | | 1 3.0|
Glands, Hyperplasia | 1 1 1 2 | 8 1.1|
Mucosa, Inflammation, Suppurative | 2 | 2 2.0|
Olfactory Epithelium, Metaplasia | 1 | 4 1.0|
Submucosa, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Dilatation | 2 2 1 2 1 1 1 2 2 2 2 2 2 1 1 2 2 2 2 2 2 | 41 1.7|
Mediastinum, Hyperplasia, Lymphoid | 4| 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| |
DAY ON TEST | 1| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 0| 3| |
| 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 5| 2| 2| 1| 2| 8| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 2 2 2 1 1 1 1 1 2 1 2 1 2 1 1 1 1 1 1 1 2 1| 39 1.2|
Inflammation, Suppurative | 3 2 | 4 2.8|
Cortex, Metaplasia, Osseous | | 1 4.0|
Renal Tubule, Dilatation, Diffuse | | 1 2.0|
Renal Tubule, Regeneration | 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1| 32 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 |
Inflammation, Chronic | | 2 3.0|
Inflammation, Suppurative | 4 4 4 | 4 3.8|
Transitional Epithelium, Necrosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 7| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7|
| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + +|
__________________________________________________________________________|
Gallbladder | A + + M A|
__________________________________________________________________________|
Intestine Large | + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A|
__________________________________________________________________________|
Intestine Small | + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + +|
Basophilic Focus | 3 |
Cyst, Multiple | |
Inflammation, Chronic, Multifocal | 1 |
Proliferation Connective Tissue | |
__________________________________________________________________________|
Pancreas | + + + + + +|
Cyst | X |
__________________________________________________________________________|
Salivary Glands | M + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + +|
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + +|
Ulcer, Multiple | 2 |
__________________________________________________________________________|
Tooth | + |
Abscess | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + +|
__________________________________________________________________________|
Heart | + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + +|
Subcapsular, Hyperplasia | 2 2 1 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + I +|
__________________________________________________________________________|
Parathyroid Gland | M + M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + M|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 7| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7|
| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + +|
__________________________________________________________________________|
Penis | +|
Inflammation, Necrotizing | 2|
__________________________________________________________________________|
Preputial Gland | + + + + + |
Cyst | X |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Prostate | + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + +|
__________________________________________________________________________|
Lymph Node | + + + M + + +|
Mesenteric, Hemorrhage, Acute | 4|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + I M +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + A|
Atrophy | |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | M M M + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + +|
Hair Follicle, Atrophy | 3 3 2 |
Prepuce, Ulcer | 2 |
Sebaceous Gland, Hyperplasia | |
Subcutaneous Tissue, Edema | 2 |
Subcutaneous Tissue, Inflammation, | |
Acute | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
Thalamus, Mineralization | 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 7| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7|
| 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic, Multifocal | 2 2|
Alveolus, Adenomatosis, Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Mucosa, Inflammation, Suppurative | 2 2 2 2 1 1 1 1 1 2 1 1 1 2 2 2 1 2 2 2 1 1 1 2|
Olfactory Epithelium, Metaplasia | 3 3 2 2 3 1 3 3 2 3 1 3 2 2 3 3 3 1 3 3 2 3 3 3 2|
Respiratory Epithelium, Dysplasia | |
Respiratory Epithelium, Hyperplasia, | |
Basal Cell | |
Respiratory Epithelium, Hyperplasia | 1 2 2 2 1 2 1 2 2 2 2 1 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 1 |
Respiratory Epithelium, Regeneration | 2 1 1 2 2 2 1 2 2 1 3 2 1 1 2 2 2 1 1 2 2 1 1|
Submucosa, Angiectasis | 3 |
__________________________________________________________________________|
Trachea | + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 4|
Capsule, Fibrosis | |
Cortex, Cyst | |
Medulla, Cyst | 2 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + +|
Calculus Micro Observation Only | X |
Inflammation, Suppurative | 3 |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 5| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 7| |
| 4| 9| 2| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + +| 11 |
__________________________________________________________________________|____________|
Gallbladder | M + M M + M| 4 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + M M M| 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + +| 13 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + +| 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + +| 11 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + +| 13 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + +| 19 |
Basophilic Focus | | 1 3.0|
Cyst, Multiple | X | 1 |
Inflammation, Chronic, Multifocal | | 1 1.0|
Proliferation Connective Tissue | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + +| 12 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + +| 10 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + +| 15 |
Hyperkeratosis | | 1 2.0|
Hyperplasia, Squamous | | 1 3.0|
Ulcer | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + +| 15 |
Ulcer, Multiple | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Abscess | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + +| 11 |
__________________________________________________________________________|____________|
Heart | + + + + + +| 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + +| 11 |
Subcapsular, Hyperplasia | 1 2 1 1 1 2| 10 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + +| 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + I +| 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + +| 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M M| 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 5| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 7| |
| 4| 9| 2| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | M + M + + +| 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + +| 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | M + + + + +| 10 |
__________________________________________________________________________|____________|
Penis | + | 2 |
Inflammation, Necrotizing | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 9 |
Cyst | X X X | 4 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 2 | 3 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + +| 11 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + +| 10 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + +| 11 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + +| 11 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + +| 11 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 15 |
Mesenteric, Hemorrhage, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + + M| 7 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + M +| 9 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + M + + + + + +| 16 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | M + M + + M| 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + +| 17 |
Hair Follicle, Atrophy | 2 2 | 5 2.4|
Prepuce, Ulcer | 2 2| 3 2.0|
Sebaceous Gland, Hyperplasia | 3 | 1 3.0|
Subcutaneous Tissue, Edema | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 5| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 7| |
| 4| 9| 2| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + +| 11 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + +| 11 |
Thalamus, Mineralization | 2 2| 3 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + +| 11 |
__________________________________________________________________________|____________|
Lung | + + + + + + + +| 19 |
Infiltration Cellular, Histiocyte | 4 | 1 4.0|
Inflammation, Chronic, Multifocal | 1 | 3 1.7|
Alveolus, Adenomatosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 47 2.0|
Mucosa, Inflammation, Suppurative | 1 2 1 2 2 1 1 1 2 1 1 1 3 2 2 1 1 2 3 1 1 2 2 1| 48 1.5|
Olfactory Epithelium, Metaplasia | 2 3 2 3 3 3 3 2 3 3 2 3 3 3 3 1 3 3 3 3 3 3 3 2| 49 2.6|
Respiratory Epithelium, Dysplasia | 3 | 1 3.0|
Respiratory Epithelium, Hyperplasia, | | |
Basal Cell | 4 | 1 4.0|
Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 1 1 1 2 1| 25 1.6|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 4 1.3|
Respiratory Epithelium, Regeneration | 1 2 3 3 2 1 2 2 2 2 2 2 2 2 1 1 2 2 2 2 1 3 2| 46 1.8|
Submucosa, Angiectasis | 3 | 2 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + +| 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + +| 15 |
Inflammation, Chronic | 1 1 1 | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| |
DAY ON TEST | 5| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 7| |
| 4| 9| 2| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 4.0|
Capsule, Fibrosis | 2 | 1 2.0|
Cortex, Cyst | X X | 2 |
Medulla, Cyst | | 1 2.0|
Renal Tubule, Regeneration | 1 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + +| 11 |
Calculus Micro Observation Only | | 1 |
Inflammation, Suppurative | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | X X |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Multifocal | 2 |
Necrosis, Coagulative | 4 |
Bile Duct, Cyst | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Acute, | |
Focal | |
Myocardium, Inflammation, Chronic | 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Hyperplasia | 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2 1 1 1 2 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia, Focal | 2|
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M + + M M + + + + + + + M M + M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + |
Cyst | X X X X |
Cyst, Multiple | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + M + + + + M + + + + + + + + M|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + M M +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + + + M + + + + M + M + + M + + + + M M M +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + M + + M + M + + M + + + + + + M M M|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 2 3 |
__________________________________________________________________________|
Thymus | M + + + + + M + + I + M M M + + + + + + + M M + +|
Mediastinum, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M M M M M M + M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 0| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Mineralization | |
Hypothalamus, Atrophy | 4 |
Thalamus, Mineralization | 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Infiltration Cellular, Histiocyte | 2 3 |
Inflammation, Chronic, Multifocal | 1 2 2 1 2 1 1 1 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia | 3 2 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Mucosa, Inflammation, Suppurative | 3 2 2 3 2 3 2 2 2 3 2 2 1 2 2 2 1 2 2 1 2 1 1|
Olfactory Epithelium, Metaplasia | 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Respiratory Epithelium, Dysplasia, | |
Focal | 2 |
Respiratory Epithelium, Dysplasia | 2 |
Respiratory Epithelium, Hyperplasia, | |
Basal Cell | 2 2 2 |
Respiratory Epithelium, Hyperplasia | 3 3 2 2 2 2 2 2 2 2 2 1 2 1 2 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 1 2 2 2 |
Respiratory Epithelium, Regeneration | 2 2 2 2 2 3 2 1 1 2 2 1 2 3 2 2 2 2 3 2 2 2 3|
Submucosa, Angiectasis | 2 2 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + M + + + +|
Epithelium, Metaplasia, Squamous | 2 |
Glands, Dilatation | 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 1 1 1 1 2 1 1 1 1 1 1 2 1|
Renal Tubule, Regeneration | 2 1 2 2 1 2 2 2 1 2 1 2|
Renal Tubule, Regeneration, | |
Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | 2 1 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + A + + + M + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + + A + + + I + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + M + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Focal Cellular Change | | 2 |
Inflammation, Acute, Focal | 1 | 1 1.0|
Inflammation, Chronic, Multifocal | 1 | 2 1.5|
Necrosis, Coagulative | | 1 4.0|
Bile Duct, Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 2 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 2 | 1 2.0|
Ulcer | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
Peridontal Tissue, Inflammation, | | |
Chronic | 3 3 | 3 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myocardium, Inflammation, Acute, | | |
Focal | 2 | 1 2.0|
Myocardium, Inflammation, Chronic | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Hyperplasia | 1 1 2 3 1 2 2 2 1 1 1 2 2 2 2 1 2 3 2 1 1 1 1 2 1| 49 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | X | 1 |
Hyperplasia, Focal | 2 | 2 2.0|
Hypertrophy, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | M + + + + + + + + + + A + + + + + + + + I + + + +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + M M M M + M M M + M M M M M + M M M + + M| 23 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 49 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 8 |
Cyst | 1 | 5 1.0|
Cyst, Multiple | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + A + M + + + + + + M + + + +| 44 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + A + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | M + + + + + + + + + M M + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + M M + + + M M M + + M M M + M M + + + + +| 29 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + + + M M + M M + M + + + M + + + + M + +| 33 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Atrophy | 2 2 | 2 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + M + + + M + + M M M + + M + M M + + M + M M +| 31 |
Mediastinum, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M + M M M M M M M M M M M M M M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebrum, Mineralization | 2 | 1 2.0|
Hypothalamus, Atrophy | | 1 4.0|
Thalamus, Mineralization | 1 2 1| 8 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | | 2 2.5|
Inflammation, Chronic, Multifocal | 1 2 2 1 1 1 1 1 1 2 1 1| 21 1.3|
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Glands, Hyperplasia | 3 3 3 3 3 3 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3| 48 3.0|
Mucosa, Inflammation, Suppurative | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2| 47 2.0|
Olfactory Epithelium, Metaplasia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 3 3| 50 3.0|
Respiratory Epithelium, Dysplasia, | | |
Focal | | 1 2.0|
Respiratory Epithelium, Dysplasia | 1 1 | 3 1.3|
Respiratory Epithelium, Hyperplasia, | | |
Basal Cell | 1 3 2 3 | 7 2.1|
Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 40 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 2 | 8 1.9|
Respiratory Epithelium, Regeneration | 2 2 2 2 2 2 2 2 2 3 3 2 2 3 2 2 2 2 2 2 2 3 2| 46 2.1|
Submucosa, Angiectasis | | 5 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + A + + + + + + + + + + + + +| 48 |
Epithelium, Metaplasia, Squamous | | 1 2.0|
Glands, Dilatation | 1 1 1 2 1 1 1 1 1 2 2 2 1 1| 27 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05080-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 1 2| 30 1.2|
Renal Tubule, Regeneration | 2 1 2 1 1 2 2 1 2 2 2 1 1 1 2 1 2 1 2 1| 32 1.6|
Renal Tubule, Regeneration, | | |
Multifocal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 |
Inflammation, Chronic, Multifocal | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
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