TDMS Study 05080-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/10/94
EXP: 05080 ALLYL GLYCIDYL ETHER TIME: 20:42:49
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 56666
CONT: N01ES38061 CAS: 106-92-3
PATHOLOGIST: R. BUSCH
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/10/94
EXP: 05080 ALLYL GLYCIDYL ETHER TIME: 20:42:49
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 56666
CONT: N01ES38061 CAS: 106-92-3
PATHOLOGIST: R. BUSCH
ALLYL GLYCIDYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 111 474 514 608 625 635 651 661 667 703 |
| 715 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 54 570 579 607 607 633 667 673 677 722 |
| 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 4 CENSORED DEATHS 0 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 89 283 690 701 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ALLYL GLYCIDYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.0 98.0 98.0 98.0 96.0 94.0 94.0 84.0 76.0 |
| | |
| | |
|5 PPM | 98.0 98.0 98.0 98.0 98.0 98.0 98.0 94.0 88.0 78.0 |
| | |
| | |
|10 PPM | 98.0 98.0 98.0 96.0 96.0 96.0 96.0 96.0 96.0 92.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 5 PPM 10 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 78.0% 92.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.054N P=0.968N P=0.058N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 590.4 591.9 440.8 |
|NATURAL DEATHS (C) | (48.7) (56.0) ( 152) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 695.7 698.8 705.9 |
|(STANDARD ERROR) | (14.1) (14.4) (15.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ALLYL GLYCIDYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 68 227 367 487 534 579 581 638 642 642 |
| 658 688 693 696 708 723 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 334 367 548 604 641 659 665 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 9 CENSORED DEATHS 0 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 3 327 589 602 620 688 694 727 727 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ALLYL GLYCIDYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.0 98.0 96.0 96.0 94.0 94.0 90.0 86.0 78.0 66.0 |
| | |
| | |
|5 PPM | 100.0 100.0 100.0 98.0 96.0 96.0 96.0 92.0 86.0 84.0 |
| | |
| | |
|10 PPM | 98.0 98.0 98.0 96.0 96.0 96.0 96.0 92.0 90.0 82.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 5 PPM 10 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.0% 84.0% 82.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.068N P=0.068N P=0.101N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 567.9 567.0 553.0 |
|NATURAL DEATHS (C) | (45.1) (50.4) (80.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 674.9 703.9 698.1 |
|(STANDARD ERROR) | (18.6) (11.4) (16.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ALLYL GLYCIDYL ETHER
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
5 PPM = 2
10 PPM = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
|
| 2 3 1 3 1 2
|
P 96 + 3 1 1 22 3
E |
R | 1 2 1 3 3
C |
E 92 + 1 1 3 3
N |
T | 2 11
|
S 88 + 1 1 2
U |
R | 1 122
V |
I 84 + 11
V |
A | 12 1 2
L |
80 + 1 1
|
| 2 2
|
76 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 5 obs hidden.
ALLYL GLYCIDYL ETHER
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
5 PPM = 2
10 PPM = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 13 1 2
|
| 3 1 1 32 2
| 1 3 1 2 3
95 +
| 1 1 2 332
P | 1 1 32 3 2
E |
R 90 + 1 1 3 2 2 3
C |
E | 33
N | 1 1 2 3 23
T 85 +
| 2 2
S | 3 3
U |
R 80 + 1 1
V |
I | 1 1
V |
A 75 +
L | 11
| 1 1
|
70 + 1 1
|
|
| 1 1
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
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