TDMS Study 05080-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
ALLYL GLYCIDYL ETHER
NTP Experiment-Test: 05080-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
Facility: Battelle Northwest
Chemical CAS #: 106-92-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 9 8 5
Moribund 17 12 20
Survivors
Terminal Sacrifice 24 30 25
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (47) (50) (49)
Acanthosis 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (34) (35) (38)
Granuloma 1 (3%)
Hemorrhage 1 (3%)
Inflammation 1 (3%)
Parasite Metazoan 3 (9%) 2 (6%) 3 (8%)
Intestine Large, Colon (45) (45) (46)
Inflammation, Suppurative 1 (2%) 1 (2%)
Necrosis 1 (2%)
Parasite Metazoan 4 (9%) 2 (4%) 5 (11%)
Ulcer 1 (2%)
Intestine Large, Rectum (46) (45) (43)
Hyperplasia, Lymphoid 1 (2%)
Parasite Metazoan 2 (4%) 3 (7%)
Intestine Small, Jejunum (41) (43) (44)
Inflammation, Suppurative 1 (2%)
Muscularis, Hyperplasia 1 (2%)
Liver (50) (48) (49)
Angiectasis 1 (2%) 3 (6%) 3 (6%)
Basophilic Focus 2 (4%)
Basophilic Focus, Multiple 1 (2%)
Clear Cell Focus 1 (2%) 1 (2%) 2 (4%)
Developmental Malformation 1 (2%) 1 (2%)
Eosinophilic Focus 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 7 (14%) 4 (8%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Leukocytosis 1 (2%) 1 (2%)
Necrosis 2 (4%) 3 (6%) 3 (6%)
Vacuolization Cytoplasmic 2 (4%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 3 (6%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hepatocyte, Cytomegaly 1 (2%)
Mesentery (1) (3)
Artery, Inflammation 1 (100%) 1 (33%)
Pancreas (50) (48) (49)
Atrophy 1 (2%) 3 (6%) 2 (4%)
Inflammation, Chronic 1 (2%)
Acinus, Hyperplasia 2 (4%)
Artery, Inflammation 1 (2%) 5 (10%)
Pharynx (2)
Necrosis 1 (50%)
Ulcer 1 (50%)
Epithelium, Hyperplasia 1 (50%)
Palate, Ulcer 1 (50%)
Salivary Glands (48) (47) (48)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Karyomegaly 4 (8%) 1 (2%) 2 (4%)
Stomach, Forestomach (50) (47) (46)
Acanthosis 1 (2%) 3 (6%) 2 (4%)
Hyperkeratosis 1 (2%)
Perforation 1 (2%)
Stomach, Glandular (50) (48) (44)
Erosion 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%) 2 (4%) 2 (5%)
Tooth (1) (1)
Inflammation, Suppurative 1 (100%)
Incisor, Developmental Malformation 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50)
Cardiomyopathy 7 (14%) 4 (8%) 5 (10%)
Embolus Bacterial 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Artery, Mineralization 1 (2%) 1 (2%)
Atrium, Thrombosis 2 (4%)
Myocardium, Mineralization 1 (2%)
Myocardium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (49)
Angiectasis 30 (60%) 36 (73%) 22 (45%)
Angiectasis, Multiple 1 (2%)
Atrophy 1 (2%)
Cyst 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 16 (32%) 11 (22%) 12 (24%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 13 (26%) 11 (22%) 9 (18%)
Adrenal Gland, Medulla (49) (48) (47)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 8 (16%) 10 (21%) 4 (9%)
Hyperplasia, Multiple 2 (4%)
Parathyroid Gland (26) (32) (33)
Hyperplasia 1 (4%)
Pituitary Gland (50) (45) (48)
Hemorrhage 1 (2%)
Pars Distalis, Cyst 1 (2%) 2 (4%)
Pars Distalis, Hyperplasia 4 (8%) 5 (10%)
Thyroid Gland (49) (47) (47)
Ultimobranchial Cyst 4 (8%) 9 (19%) 4 (9%)
C-Cell, Hyperplasia 10 (20%) 12 (26%) 10 (21%)
Follicular Cell, Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (43) (45) (43)
Cyst 6 (14%) 12 (27%) 14 (33%)
Cyst, Multiple 1 (2%)
Inflammation, Suppurative 15 (35%) 13 (29%) 15 (35%)
Ovary (49) (48) (49)
Cyst 4 (8%) 10 (21%) 8 (16%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Capsule, Hyperplasia 1 (2%)
Uterus (50) (50) (50)
Inflammation, Suppurative 7 (14%) 1 (2%) 3 (6%)
Thrombosis 1 (2%)
Artery, Inflammation 1 (2%)
Endometrium, Hyperplasia 14 (28%) 22 (44%) 12 (24%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Endometrium, Metaplasia, Squamous 2 (4%) 5 (10%) 6 (12%)
Lumen, Dilatation 2 (4%) 4 (8%) 3 (6%)
Lumen, Hemorrhage 2 (4%) 1 (2%)
Wall, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (45) (48)
Atrophy 4 (8%)
Lymph Node (48) (50) (49)
Mesenteric, Hemorrhage 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Bronchial (34) (39) (43)
Fibrosis 1 (2%)
Hemorrhage 1 (3%) 1 (3%) 1 (2%)
Lymph Node, Mandibular (43) (45) (44)
Hemorrhage 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Spleen (50) (48) (49)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 6 (12%) 5 (10%) 8 (16%)
Artery, Inflammation 1 (2%)
Thymus (41) (47) (43)
Cyst 4 (9%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50)
Cyst 1 (2%)
Galactocele 2 (4%) 1 (2%) 1 (2%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Skin (48) (49) (49)
Acanthosis 2 (4%)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (49) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%)
Osteopetrosis 1 (2%)
Cranium, Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50)
Compression 3 (6%) 5 (10%) 2 (4%)
Gliosis 1 (2%)
Hemorrhage 2 (4%) 2 (4%)
Ventricle, Dilatation 1 (2%)
Spinal Cord (1)
White Matter, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (48) (48)
Foreign Body 1 (2%)
Inflammation, Suppurative 3 (6%) 5 (10%)
Epithelium, Hyperplasia 1 (2%)
Lung (49) (50) (49)
Foreign Body 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 2 (4%)
Inflammation, Granulomatous 3 (6%) 7 (14%) 3 (6%)
Leukocytosis 1 (2%)
Thrombosis 2 (4%)
Alveolar Epithelium, Hyperplasia 4 (8%) 14 (28%) 14 (29%)
Alveolus, Fibrosis 1 (2%) 2 (4%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 21 (43%) 41 (82%) 31 (63%)
Alveolus, Inflammation, Suppurative 13 (27%) 5 (10%) 4 (8%)
Artery, Inflammation 1 (2%)
Artery, Mineralization 20 (41%) 16 (32%) 15 (31%)
Bronchiole, Hyperplasia 1 (2%)
Pleura, Inflammation, Chronic 1 (2%)
Nose (49) (48) (47)
Inflammation, Suppurative 5 (10%) 7 (15%) 11 (23%)
Glands, Dilatation 9 (18%) 29 (60%) 39 (83%)
Nasolacrimal Duct, Inflammation, Suppurative 4 (8%) 1 (2%)
Olfactory Epithelium, Degeneration 46 (96%) 47 (100%)
Olfactory Epithelium, Metaplasia 4 (8%) 6 (13%)
Olfactory Epithelium, Metaplasia, Squamous 9 (19%) 31 (66%)
Respiratory Epithelium, Dysplasia 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%) 18 (38%) 22 (47%)
Respiratory Epithelium, Metaplasia, Squamous 37 (77%) 38 (81%)
Trachea (49) (49) (48)
Inflammation, Suppurative 2 (4%) 1 (2%)
Mineralization 1 (2%)
Glands, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3)
Cataract, Multiple 1 (33%)
Lacrimal Gland (5) (1) (2)
Hyperplasia 1 (100%)
Inflammation, Chronic 3 (60%) 1 (100%) 2 (100%)
Inflammation, Suppurative 1 (20%)
Karyomegaly 4 (80%) 1 (100%) 2 (100%)
Necrosis 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (48) (49)
Cyst 1 (2%) 3 (6%)
Nephropathy, Chronic 48 (96%) 42 (88%) 46 (94%)
Pelvis, Dilatation 1 (2%)
Pelvis, Hyperplasia 3 (6%) 3 (6%) 2 (4%)
Pelvis, Mineralization 15 (30%) 15 (31%) 15 (31%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Mineralization 14 (28%) 18 (38%) 11 (22%)
Urinary Bladder (49) (47) (47)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 27 27 29
Moribund 11 12 13
Survivors
Moribund 1
Terminal Sacrifice 12 10 8
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (23) (21) (15)
Parasite Metazoan 2 (9%) 1 (5%) 2 (13%)
Artery, Inflammation 1 (7%)
Intestine Large, Colon (39) (38) (34)
Parasite Metazoan 4 (10%) 3 (8%) 4 (12%)
Intestine Large, Rectum (40) (42) (38)
Parasite Metazoan 4 (10%) 2 (5%)
Artery, Inflammation 2 (5%)
Intestine Small, Ileum (24) (27) (23)
Artery, Inflammation 1 (4%)
Liver (49) (49) (47)
Angiectasis 1 (2%) 1 (2%) 2 (4%)
Basophilic Focus 1 (2%) 1 (2%)
Clear Cell Focus 1 (2%) 4 (8%) 3 (6%)
Developmental Malformation 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 1 (2%)
Inflammation, Granulomatous 3 (6%)
Inflammation, Suppurative 1 (2%)
Necrosis 3 (6%) 2 (4%)
Bile Duct, Cyst 1 (2%)
Bile Duct, Fibrosis 1 (2%) 2 (4%) 6 (13%)
Bile Duct, Hyperplasia 1 (2%) 2 (4%)
Mesentery (1) (1)
Inflammation 1 (100%)
Artery, Inflammation 1 (100%)
Pancreas (48) (48) (44)
Atrophy 2 (4%) 6 (13%) 2 (5%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Acinus, Hyperplasia 1 (2%) 1 (2%) 2 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation 6 (13%) 7 (15%) 9 (20%)
Artery, Thrombosis 1 (2%)
Salivary Glands (50) (46) (47)
Cyst 1 (2%)
Inflammation, Chronic 12 (24%) 6 (13%) 5 (11%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 2 (4%)
Karyomegaly 21 (42%) 23 (50%) 20 (43%)
Stomach (48) (49) (46)
Artery, Inflammation 1 (2%) 1 (2%)
Stomach, Forestomach (45) (43) (44)
Acanthosis 2 (5%)
Hyperkeratosis 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Stomach, Glandular (48) (48) (46)
Cyst 1 (2%)
Developmental Malformation 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Necrotizing 1 (2%)
Mineralization 4 (8%) 1 (2%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Artery, Inflammation 2 (4%) 1 (2%)
Tongue (2)
Hyperplasia, Squamous 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50)
Cardiomyopathy 12 (24%) 12 (24%) 19 (38%)
Inflammation, Suppurative 2 (4%)
Aortic Valve, Mineralization 2 (4%)
Artery, Inflammation 2 (4%) 1 (2%) 1 (2%)
Artery, Mineralization 7 (14%) 2 (4%) 2 (4%)
Atrium, Mineralization 1 (2%)
Atrium, Thrombosis 8 (16%) 3 (6%) 8 (16%)
Endocardium, Fibrosis 1 (2%) 1 (2%)
Myocardium, Hemorrhage 1 (2%)
Ventricle, Mineralization 1 (2%)
Ventricle, Thrombosis 1 (2%)
Ventricle Right, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (48) (48)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 8 (17%) 15 (31%) 13 (27%)
Hypertrophy 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 10 (21%) 14 (29%) 17 (35%)
Adrenal Gland, Medulla (47) (47) (47)
Hemorrhage 1 (2%)
Hyperplasia 10 (21%) 11 (23%) 10 (21%)
Hyperplasia, Multiple 1 (2%)
Mineralization 1 (2%)
Islets, Pancreatic (48) (48) (45)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (36) (30) (38)
Hyperplasia 2 (6%) 1 (3%) 1 (3%)
Hyperplasia, Multiple 1 (3%)
Pituitary Gland (47) (46) (44)
Pars Distalis, Cyst 2 (4%) 3 (7%) 3 (7%)
Pars Distalis, Hyperplasia 2 (4%) 2 (4%) 4 (9%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (43) (46) (46)
Inflammation, Chronic 1 (2%)
Ultimobranchial Cyst 4 (9%) 2 (4%) 3 (7%)
C-Cell, Hyperplasia 10 (23%) 7 (15%) 7 (15%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (43) (42) (42)
Artery, Inflammation 1 (2%)
Preputial Gland (49) (48) (46)
Cyst 7 (14%) 2 (4%) 2 (4%)
Hyperplasia 1 (2%)
Inflammation, Suppurative 22 (45%) 23 (48%) 15 (33%)
Prostate (49) (49) (46)
Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Suppurative 3 (6%) 4 (8%) 4 (9%)
Mineralization 1 (2%)
Artery, Inflammation 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Seminal Vesicle (49) (49) (45)
Inflammation, Suppurative 3 (6%) 2 (4%) 4 (9%)
Artery, Inflammation 1 (2%) 1 (2%)
Testes (49) (49) (49)
Infarct 1 (2%)
Mineralization 1 (2%) 6 (12%) 7 (14%)
Artery, Inflammation 10 (20%) 10 (20%) 11 (22%)
Seminiferous Tubule, Atrophy 7 (14%) 6 (12%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (46) (48) (44)
Fibrosis 1 (2%)
Lymph Node (48) (44) (45)
Fibrosis 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Renal, Hemorrhage 3 (6%)
Lymph Node, Bronchial (40) (29) (38)
Hemorrhage 5 (13%) 6 (16%)
Inflammation, Granulomatous 1 (3%)
Lymph Node, Mandibular (44) (40) (42)
Hemorrhage 2 (5%) 3 (7%)
Hyperplasia, Lymphoid 1 (2%) 1 (3%) 2 (5%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (5%)
Spleen (50) (49) (46)
Hematopoietic Cell Proliferation 4 (8%) 1 (2%)
Hemorrhage 2 (4%)
Infarct 1 (2%) 1 (2%)
Thymus (46) (46) (44)
Hemorrhage 2 (5%)
Thrombosis 1 (2%)
Artery, Inflammation 1 (2%) 2 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (49) (49)
Giant Cell 1 (2%)
Granuloma 1 (2%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49)
Osteoporosis 1 (2%)
Skeletal Muscle (1) (1)
Laryngeal, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Compression 1 (2%) 1 (2%)
Demyelination 1 (2%)
Gliosis 1 (2%)
Hemorrhage 4 (8%) 2 (4%) 3 (6%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Ventricle, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (39) (45) (43)
Inflammation, Chronic 2 (5%) 2 (5%)
Inflammation, Suppurative 1 (2%) 2 (5%)
Artery, Inflammation 1 (2%)
Epithelium, Hyperplasia 2 (5%)
Lung (42) (48) (45)
Foreign Body 1 (2%) 1 (2%)
Hemorrhage 7 (17%) 7 (15%) 8 (18%)
Inflammation, Granulomatous 5 (12%) 3 (6%) 2 (4%)
Leukocytosis 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (5%) 6 (13%) 5 (11%)
Alveolus, Edema 1 (2%) 2 (4%) 2 (4%)
Alveolus, Fibrosis 2 (5%) 4 (8%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 7 (17%) 17 (35%) 19 (42%)
Alveolus, Inflammation, Suppurative 6 (14%) 5 (10%) 7 (16%)
Alveolus, Mineralization 1 (2%)
Artery, Inflammation 7 (17%) 12 (25%) 6 (13%)
Artery, Mineralization 18 (43%) 22 (46%) 16 (36%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
____________________________________________________________________________________________________________________________________
OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Bronchiole, Infiltration Cellular, Histiocyte 1 (2%)
Bronchiole, Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Nose (44) (46) (43)
Foreign Body 1 (2%) 3 (7%) 1 (2%)
Inflammation, Suppurative 9 (20%) 27 (59%) 18 (42%)
Inflammation, Membranous 3 (7%) 4 (9%) 7 (16%)
Glands, Dilatation 8 (18%) 20 (43%) 21 (49%)
Nasolacrimal Duct, Inflammation, Suppurative 7 (16%) 3 (7%) 9 (21%)
Olfactory Epithelium, Degeneration 45 (98%) 43 (100%)
Olfactory Epithelium, Metaplasia 6 (13%) 9 (21%)
Olfactory Epithelium, Metaplasia, Squamous 19 (41%) 35 (81%)
Respiratory Epithelium, Hyperplasia 4 (9%) 33 (72%) 30 (70%)
Respiratory Epithelium, Metaplasia, Squamous 4 (9%) 40 (87%) 38 (88%)
Trachea (40) (45) (42)
Inflammation, Chronic 2 (5%)
Inflammation, Suppurative 1 (3%)
Artery, Inflammation 1 (2%)
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SPECIAL SENSES SYSTEM
Eye (2) (1) (2)
Cataract 1 (50%)
Harderian Gland (3) (2) (8)
Hyperplasia 2 (67%)
Inflammation, Chronic 1 (33%) 8 (100%)
Karyomegaly 7 (88%)
Lacrimal Gland (19) (21) (7)
Hyperplasia 1 (14%)
Inflammation, Chronic 19 (100%) 21 (100%) 7 (100%)
Inflammation, Suppurative 1 (5%)
Karyomegaly 19 (100%) 21 (100%) 7 (100%)
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URINARY SYSTEM
Kidney (50) (49) (48)
Cyst 1 (2%) 1 (2%) 2 (4%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%)
Nephropathy, Chronic 49 (98%) 49 (100%) 47 (98%)
Artery, Mineralization 1 (2%)
Glomerulus, Mineralization 1 (2%)
Pelvis, Hemorrhage 1 (2%)
Pelvis, Hyperplasia 2 (4%) 2 (4%) 2 (4%)
Pelvis, Inflammation, Suppurative 2 (4%) 3 (6%)
Pelvis, Mineralization 3 (6%) 3 (6%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:04
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OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM
MALE MALE MALE
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URINARY SYSTEM - CONT
Renal Tubule, Mineralization 2 (4%) 1 (2%)
Urinary Bladder (46) (49) (44)
Calculus Gross Observation 2 (4%)
Calculus Micro Observation Only 3 (7%)
Hemorrhage 1 (2%)
Hyperplasia 2 (4%) 1 (2%) 3 (7%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%) 4 (9%)
Artery, Inflammation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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