TDMS Study 05080-01 Pathology Tables
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
Facility: Battelle Northwest
Chemical CAS #: 106-92-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|
| 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + M + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + M + + + + + A M + + M M M + + + M + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + A + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small | + A + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + M + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + A + + A + + + M + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + A + + A + + + M + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant Histiocytic | |
Neoplastic Nodule | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Histiocytic | |
Pheochromocytoma Benign | X X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M M M + + M M M + M M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
C-Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|
| 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma, Multiple | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + M + M M + M + + + + + + + + + M + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
Granulosa-Theca Tumor Benign | X |
Hamartoma | X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Lymphoma Malignant Histiocytic | |
Polyp Stromal | X X X|
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + M + + + + + + + + M + +|
Pancreatic, Lymphoma Malignant | |
Histiocytic | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + M + M M + M + M + + + M + M M + M M +|
Basosquamous Tumor Malignant, | |
Metastatic, Thymus | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + M M + + + + + + + + M + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + + M M + + + + + + + + + M + + M A +|
Basosquamous Tumor Malignant | |
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|
DAY ON TEST | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|
| 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + M + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
Granular Cell Tumor Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant, | |
Metastatic, Thymus | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Lacrimal Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7| |
DAY ON TEST | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2| |
| 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + + M + + + M + + + + M + + + + A M + M M +| 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + A + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M + + + + A + M + + + + + + A + + + + A + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + A + + + + A + + + + A| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X X | 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Neoplastic Nodule | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Pharynx | + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 3 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
Pheochromocytoma Benign | X X | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M M M + + I M M M + M + M M + M M + M +| 26 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7| |
DAY ON TEST | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2| |
| 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X X X X X X X X X X| 26 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
C-Cell, Adenoma | X X X X X X| 10 |
C-Cell, Adenoma, Multiple | X | 1 |
C-Cell, Carcinoma | X X X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| 43 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Granulosa Cell Tumor Benign | | 1 |
Granulosa-Theca Tumor Benign | | 1 |
Hamartoma | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X X| 2 |
Lymphoma Malignant Histiocytic | X | 1 |
Polyp Stromal | X X X X X X X| 10 |
Sarcoma Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + M + + + + + + M + + + + M M + + + + + +| 34 |
Basosquamous Tumor Malignant, | | |
Metastatic, Thymus | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M + + M + + + + + + + + + M + +| 43 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + M + + + + M + + + M + + +| 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7| |
DAY ON TEST | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2| |
| 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Basosquamous Tumor Malignant | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X | 2 |
Fibroadenoma | X X X X X X X X X X X X X| 23 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + M + + + + + + + + + + + + M + +| 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
Granular Cell Tumor Benign | X X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lung | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Basosquamous Tumor Malignant, | | |
Metastatic, Thymus | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|
| 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + A + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A M M + M M + M M + + + + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + M A M + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A A + + + + + A + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +|
Adenoma | X X|
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + A + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + A + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + A + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + A + + + + + +|
Adenoma | X X X X |
Adenoma, Multiple | |
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + A + + + + + +|
Lymphoma Malignant | X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | M + M + + M M + + M + + M + + M + + M + + + + + M|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|
| 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + I + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + + +|
C-Cell, Adenoma | X X X X X X X|
C-Cell, Adenoma, Multiple | X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + M M + + M + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + A + + + + + +|
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma Stromal, Metastatic, Uterus | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X X X |
Sarcoma | X |
Sarcoma Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + M + + + + + M + + + + A + + + + A +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + M M + M + + M + + + M + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + M A + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +|
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + M + + A + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|
| 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | X X X |
Adenocarcinoma, Multiple | X |
Fibroadenoma | X X X X X X X X X X|
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + A + + + + + + A + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Carcinoma Adenosquamous | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Uterus | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + A + + + + + +|
Respiratory Epithelium, Adenoma, | |
Papillary | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + A + + + + + +|
Liposarcoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3| |
| 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + A + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + M + M + M + + + + M + M + M + + + M +| 35 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + A + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + A + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + A + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + A + A + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X | 3 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 5 |
Adenoma, Multiple | X | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3| |
| 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 1 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + + M + + M + + M + M + + + + + + + M M M| 32 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + + + + A + + + M + + M + + + + + + + + + + +| 45 |
Pars Distalis, Adenoma | X X X X X X X X X X| 26 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + I + A + + + + + + + + + + + + + + + +| 47 |
C-Cell, Adenoma | X X X X X X X | 14 |
C-Cell, Adenoma, Multiple | X X X | 5 |
C-Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 45 |
__________________________________________________________________________|____________|
Ovary | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Sarcoma Stromal, Metastatic, Uterus | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Polyp Stromal | X X X X | 11 |
Sarcoma | | 1 |
Sarcoma Stromal | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesenteric, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + M M + + + + M + + + + + M + + + + M + +| 39 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + M +| 45 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3| |
| 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X X | 5 |
Adenocarcinoma, Multiple | | 1 |
Fibroadenoma | X X X X X X X | 17 |
Fibroadenoma, Multiple | X X | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibroma | X | 1 |
Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Carcinoma Adenosquamous | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Sarcoma, Metastatic, Uterus | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Respiratory Epithelium, Adenoma, | | |
Papillary | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7| |
DAY ON TEST | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3| |
| 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + A + + + + + + + + + + + + + + + + + +| 48 |
Liposarcoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|
| 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + A + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + M + + + M M + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + A + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + A A + + + + + + + + A + + + + M +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + A A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + A A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + A A + + + + + + + + A + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + I + A A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
Adenoma | X |
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + + + |
Adenocarcinoma, Metastatic, Uterus | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + I + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Glandular, Adenocarcinoma, | |
Metastatic, Uterus | X |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + A + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
Adenoma | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Pheochromocytoma Benign | X X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|
| 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign, Multiple | X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + M M M + + + + + M + + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + A + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X X X |
C-Cell, Adenoma, Multiple | |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X X |
Embryonal Carcinoma | |
Granulosa Cell Tumor Malignant | X |
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Squamous Cell Carcinoma, Metastatic, | |
Uterus | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Polyp Stromal | X X |
Sarcoma Stromal | |
Squamous Cell Carcinoma | X |
Endometrium, Adenoma, Papillary | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + M + + + + + M + + + + +|
Adenocarcinoma, Metastatic, Uterus | X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + M + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|
| 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Adenocarcinoma, Metastatic, Uterus | X X |
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + M + + M + + + + + + + + + + + + + + + + + + M|
Adenocarcinoma, Metastatic, Uterus | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X |
Fibrosarcoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Diaphragm, Adenocarcinoma, | |
Metastatic, Uterus | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X X |
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Nose | + + + + + + + + A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|
| 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cell Type | |
Nephroblastoma | X |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + A + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Uterus | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3| |
| 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + M + + + M + + + + M + + + + + M + + + M M +| 38 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + A + +| 43 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 45 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Adenoma | | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Adenocarcinoma, Metastatic, Uterus | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Adenocarcinoma, Metastatic, Uterus | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + I| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + I + + + + + + + M + + + + + + M| 46 |
Squamous Cell Papilloma | | 1 |
Glandular, Adenocarcinoma, | | |
Metastatic, Uterus | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + I| 44 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Adenoma | | 2 |
Lymphoma Malignant Undifferentiated | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3| |
| 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + M + + + + + + + A + +| 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Pheochromocytoma Benign | | 3 |
Pheochromocytoma Benign, Multiple | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M + + + + + M + M M M + + M + + M M + +| 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Pars Distalis, Adenoma | X X X X X X X X X X X X X| 20 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
C-Cell, Adenoma | X X X X | 10 |
C-Cell, Adenoma, Multiple | X X | 2 |
C-Cell, Carcinoma | X X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + M + + + A M +| 43 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Adenocarcinoma, Metastatic, Uterus | | 2 |
Embryonal Carcinoma | X | 1 |
Granulosa Cell Tumor Malignant | | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Uterus | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X | 3 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Polyp Stromal | X X X X X X X | 9 |
Sarcoma Stromal | X | 1 |
Squamous Cell Carcinoma | | 1 |
Endometrium, Adenoma, Papillary | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3| |
| 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M M + + + + M M +| 43 |
Adenocarcinoma, Metastatic, Uterus | | 2 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + M + + + + + + + + + M + + + A + +| 44 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Adenocarcinoma, Metastatic, Uterus | | 2 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Thymus | M M + + + + + + + + + + + + + + + + + M + + A + +| 43 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenocarcinoma | X X | 4 |
Fibroadenoma | X X X X X X X X X X X X X X X| 20 |
Fibroadenoma, Multiple | X | 2 |
Fibrosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Diaphragm, Adenocarcinoma, | | |
Metastatic, Uterus | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7| |
DAY ON TEST | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3| |
| 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Adenocarcinoma, Metastatic, Uterus | | 2 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Nephroblastoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
Adenocarcinoma, Metastatic, Uterus | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|
DAY ON TEST | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|
| 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + A A + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + M M M + + M M + A M M M M + + + + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + A A + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + A A A I A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + A + + A A A A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + A + + A A A A M + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + A A A + + A + + A A A A A + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + A A A + + A + + A A A A A + + + A + +|
Adenocarcinoma, Mucinous | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + A + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + A + + + + + +|
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + A + + + + + +|
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + A + + A + + + + + +|
Adenoma | X |
Carcinoma | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + A + + A + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Pheochromocytoma Malignant | X X X|
Pheochromocytoma Malignant, Multiple | X |
Pheochromocytoma Benign | X X X|
Pheochromocytoma Benign, Multiple | X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + A + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|
DAY ON TEST | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|
| 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + M + + + M + + M + + + + + + + M M|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + I + + + + + + + + + A + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X|
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A A + A + + + A + +|
C-Cell, Adenoma | X X X X X|
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | M + M M + + + M + + + + + + + M + + + M + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A A + + A + + + + + +|
__________________________________________________________________________|
Lymph Node | M + + + + + + + + + + + + + + + + + + + + + + M +|
Mesenteric, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + + M M + + + + + M M + A + + + + M +|
Carcinoma, Metastatic, Thyroid Gland | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + M + + + + M + + + + + + + + + + + M +|
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Thymoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|
DAY ON TEST | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|
| 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M + + + + M + + + + A + M M M M + M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + A + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Granular Cell Tumor Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | A A + + + + + A + + + A + + A A A + A + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
__________________________________________________________________________|
Lung | + A + + + + + + + + + + + + A A A + A + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Pheochromocytoma Malignant, | |
Metastatic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + A + + + A + + + + + +|
__________________________________________________________________________|
Trachea | A A + + + + + A + + + A + + A A A + A + + + A + +|
Carcinoma, Metastatic, Thyroid Gland | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Adenoma, Multiple | X |
Carcinoma, Metastatic, Thyroid Gland | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + A + A + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|
DAY ON TEST | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|
| 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Lymphoma Malignant | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5| |
DAY ON TEST | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4| |
| 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + A A A + A + + A + +| 41 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M A + + A + + + + M M M M A A M + A M + M M M| 23 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + A A A + A + + A A +| 39 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A A A + + + + A + +| 40 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + + A + + + + A + + + A + A + A + + A A +| 35 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + A + + + + A + + + A A A + A + + A A +| 33 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + A + + A + A A A + A A A + A A + A A A| 24 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + A + + A + A A A + A A A + A A + A A A| 24 |
Adenocarcinoma, Mucinous | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + + + + + + + + + + I + + M + + + + + +| 45 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | | 1 |
Carcinoma | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Pheochromocytoma Malignant | X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5| |
DAY ON TEST | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4| |
| 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Malignant, Multiple | X | 2 |
Pheochromocytoma Benign | X X X X X X | 9 |
Pheochromocytoma Benign, Multiple | | 1 |
Bilateral, Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + + + + + + + M + + M + + + M M + M +| 36 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + I + + + + +| 47 |
Pars Distalis, Adenoma | X X X X X X X | 11 |
Pars Distalis, Carcinoma | X X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + A + + + + A + A + + + + +| 43 |
C-Cell, Adenoma | X X X | 8 |
C-Cell, Carcinoma | X X X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + M + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mesenteric, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + + M + + + +| 40 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + M +| 44 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5| |
DAY ON TEST | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4| |
| 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + M + +| 46 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Thymoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + + M + + + + M M + M M + + M M + M + + M| 27 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Fibroma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Meninges, Granular Cell Tumor Benign | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + I + A + + + + A + +| 39 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + A + + + + + + + + + + + A + A + + + + + + +| 42 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Pheochromocytoma Malignant, | | |
Metastatic | | 1 |
__________________________________________________________________________|____________|
Nose | + + + A + + + + + + + + + + + A + A + + + + A + +| 44 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + A + +| 40 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5| |
DAY ON TEST | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4| |
| 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + + A | 3 |
__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + | 19 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
Adenoma, Multiple | | 1 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|
DAY ON TEST | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|
| 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + + A + + + + + + A + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M M + + A + + + M M + M + M + + + M + A + + M M A|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + A + A + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + A + + + + + + A + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A A + + A + + + A + + A + A + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + + + + + + A + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A A + A + + + A M + A + A + + + + + A + + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + A + + + A M + A + A + + + + + A + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Hepatocellular Carcinoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + A + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | M + + M + + + + + + + + + + + + + + + + + + M + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Pheochromocytoma Benign | X X X X |
Pheochromocytoma Benign, Multiple | X X X X|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|
DAY ON TEST | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|
| 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + + M M M + + + + M + + M + + + + + + + M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Pars Distalis, Adenoma | X X X X X X|
Pars Intermedia, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X X|
C-Cell, Adenoma, Multiple | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + I + + + + + M + + + + + M + + M M + +|
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Sarcoma, Metastatic, Seminal Vesicle | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Sarcoma | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + M + + + + + + + + + + M +|
Renal, Lymphoma Malignant Histiocytic| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + M M M M M + M + + M M + M + M + + M +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + M M +|
Carcinoma, Metastatic, Harderian | |
Gland | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|
DAY ON TEST | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|
| 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + + + + + + + + + + + + M + + + + M + + + +|
__________________________________________________________________________|
Skin | + + M + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Keratoacanthoma | X|
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Schwannoma Malignant, | |
Metastatic, Brain | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Sarcoma, Metastatic, Skin | X |
Schwannoma Malignant, Metastatic, | |
Brain | X |
__________________________________________________________________________|
Nose | + + A + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + A + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|
DAY ON TEST | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|
| 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
5 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Carcinoma | X |
__________________________________________________________________________|
Lacrimal Gland | + + + + + + + + + + + + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Sarcoma, Metastatic, Seminal Vesicle | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4| |
DAY ON TEST | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1| |
| 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + A + + + + + + + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + A + A + + + + + + + + + + + + + + + + + A + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M M M + M M M M + + + A + M M A M + M + + M A M M| 21 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + M A + A + A + + A + A + + + + + + + + + A A + +| 38 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + A + + + + + + + + + + + I + + + + + A + +| 42 |
__________________________________________________________________________|____________|
Intestine Small | + A A + A A A A + + + + + + + A + + + + + A A + +| 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A A + A A A A + + + + + + + A + + + + + A A + +| 37 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + A A A A + M + A + + + A A + + + + A A + +| 27 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A A + A A A A + A + A + + + A A + + + + A A + A| 27 |
__________________________________________________________________________|____________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 1 |
Hepatocellular Carcinoma | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + A + A + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + A + A + + + + + + + + + + + + + + + + + + + M| 46 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + A + + + + I + + + + + + + + + M + + + + +| 43 |
Squamous Cell Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + A + + + + + + + +| 48 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + A + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + A + A + + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4| |
DAY ON TEST | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1| |
| 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + A + A + + M + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Histiocytic | X | 1 |
Pheochromocytoma Benign | X X X | 7 |
Pheochromocytoma Benign, Multiple | X X X | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + A + A + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M + M I + + + M M M + + M + + + + + M M +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M + A I + + M + + + + + + + + + + + + + + + +| 46 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Pars Distalis, Adenoma | X X X X X X | 12 |
Pars Intermedia, Adenoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + A A + A + A + + + + + + + + + + + + + + + + + +| 46 |
C-Cell, Adenoma | X X X X | 9 |
C-Cell, Adenoma, Multiple | | 1 |
C-Cell, Carcinoma | X | 1 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + A + + + + + + + + + + + + M + + + + + + +| 42 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X | 1 |
Sarcoma, Metastatic, Seminal Vesicle | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + A + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4| |
DAY ON TEST | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1| |
| 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + A + A + + + + + + + + + + M + + + + + + + + M| 44 |
Renal, Lymphoma Malignant Histiocytic| X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + A M + + + M + + M + + M + + + M + + M + M| 29 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M A + M + + + + + M + + + M M + + + + + + + + M| 40 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Thymus | + + A + A + + + + M + + + + + + + + + + + + + M +| 46 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M + + + + + M + + + + + + + + + M M + + +| 40 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangioma | | 1 |
Keratoacanthoma | | 1 |
Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cranium, Schwannoma Malignant, | | |
Metastatic, Brain | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + A A + A + + A + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4| |
DAY ON TEST | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1| |
| 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
5 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + + A + A + + + + + + + + + + + + + + + + + + + +| 48 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
Schwannoma Malignant, Metastatic, | | |
Brain | | 1 |
__________________________________________________________________________|____________|
Nose | + A + + A + + + + + + + + + + + + + + + + A + + +| 46 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + A A + A + + + + + + + + + + + A + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + + + + + + + + + | 21 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant Histiocytic | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X | 1 |
Sarcoma, Metastatic, Seminal Vesicle | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|
DAY ON TEST | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|
| 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | A + + A + + + + + + + + + A + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | A M M M M M + M M + + M + A + A + A M + A + M M M|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Large, Colon | A + + A + + + + + + + + + A + + + A + + + + A + A|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Large, Rectum | A + + A + + + + + + + + + A + + + A + + + + A + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small | A A + A A + + + + + + + + A + + + A + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + A A + + + A + + + + M + + + A + + + + A + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Ileum | A A + A A A + A + + A + + A + A + A M + A + A + A|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Small, Jejunum | A A + A A A + A + + A + + A + + + A + + A + A + A|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + A + + + + + + + + + + + + + + + + + + A + M|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + M A + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|
DAY ON TEST | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|
| 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + A + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + A + + + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Pheochromocytoma Malignant | X |
Pheochromocytoma Malignant, Multiple | |
Pheochromocytoma Benign | X X X X X X |
Pheochromocytoma Benign, Multiple | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + A + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + + + + M + + + + + + + M M + + M +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Pars Distalis, Adenoma | X X X X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + A + +|
C-Cell, Adenoma | X X X |
C-Cell, Adenoma, Multiple | X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + M + + + + + + + + + + + + + + + + + M I + M|
__________________________________________________________________________|
Preputial Gland | + + + M + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + A + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Seminal Vesicle | + + + A + + + + + + + + + + + + + + + + + M A + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|
DAY ON TEST | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|
| 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node | + + + A M + + + + + + + + + + + + + + + + M A + M|
Inguinal, Lymphoma Malignant | |
Histiocytic | X |
Pancreatic, Lymphoma Malignant | |
Histiocytic | X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + A M + + + + + + M + + + + + + + + + M M + M|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + A M + + + M + + + + + + + + M + + + M A + M|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M M + + + + + + + + + + +|
Carcinoma, Metastatic, Uncertain | |
Primary Site | X|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + M + M + + + + + + + M + M M M M M M|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + M + + + + + + + + + + + + + + +|
Fibroma | X |
Lip, Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + A + + + + + + + + + + + + + + + + + + + + +|
Cranium, Squamous Cell Carcinoma, | |
Metastatic, Nose | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Oligodendroglioma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
_____________________________________________________________________________________________________________________
| 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|
DAY ON TEST | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|
| 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + A + A + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Lung | + + + A + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Nose | + + + A + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Olfactory Epithelium, Adenocarcinoma,| |
Poorly Differentiated | |
Respiratory Epithelium, Adenoma, | |
Papillary | X |
Respiratory Epithelium, Squamous | |
Cell Carcinoma | X |
__________________________________________________________________________|
Trachea | + A + A A + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Harderian Gland | + + + |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Lacrimal Gland | M + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Urinary Bladder | + A + A + + + + + + + + + + + + + + + + + + A + +|
Lymphoma Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
__________________________________________________________________________|____________|
Intestine Large | + A + + A A + + + + + + + + + A A + + A + A A + +| 37 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M M + M M A + M M M A A + M + M M + + M + M A M M| 15 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A A + + A A + A + + + + + + + A A + + A + A A + +| 34 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + A + + + + + + + + + M A + + A + A A + +| 38 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + A + + A A + + + + A + + + + A A + + A + A A + +| 34 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + A A + + + + A + + + + A A + + A + A A + +| 33 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + M A + A + A A A + + + A A + + A + A A + +| 23 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + + A A + A + A A + + + + A A A + A + A A + +| 25 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + + + + + + + A + + +| 47 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + A + + + + + + + + + + A + + A + A + + +| 44 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + A + + + + + + + + + + A + + + + + + + +| 44 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + A + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Adenoma | | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
Pheochromocytoma Malignant | X X | 3 |
Pheochromocytoma Malignant, Multiple | X | 1 |
Pheochromocytoma Benign | X X X X X X | 12 |
Pheochromocytoma Benign, Multiple | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + A + + + + A + + +| 45 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + M M M + + M + M + + + + + +| 38 |
Adenoma | X X | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + A + + + + + + + I + + + + + A M A + + +| 44 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Pars Distalis, Adenoma | X X X X X X X | 13 |
Pars Intermedia, Adenoma | X| 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A + + + + A + + + + + + + + + + + + + +| 46 |
C-Cell, Adenoma | X X X X X X X | 10 |
C-Cell, Adenoma, Multiple | X | 2 |
C-Cell, Carcinoma | X | 3 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + I M + + + + M + + + + + A + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + M + + + + M + + + + + + +| 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + A + + + + + + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + A + + + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + A + + + + + + + + + A A + + + + A + + +| 44 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
Inguinal, Lymphoma Malignant | | |
Histiocytic | | 1 |
Pancreatic, Lymphoma Malignant | | |
Histiocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + M + + + M + M + + + + + + M M +| 38 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M| 42 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + A + + + + A + + +| 46 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + M + + + + + A + + + + + M + +| 44 |
Carcinoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M M + M + M + M + + M M M +| 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Fibroadenoma | X X| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibroma | | 1 |
Lip, Squamous Cell Carcinoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cranium, Squamous Cell Carcinoma, | | |
Metastatic, Nose | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant Histiocytic | | 1 |
Oligodendroglioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + A + + + + + + + + + + A + + A + A + + +| 43 |
__________________________________________________________________________|____________|
Lung | + + + + + A + + + + + + + + + + A + + A + + + + +| 45 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + A + + + + + + + + + A A + + A + A + + +| 43 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
Olfactory Epithelium, Adenocarcinoma,| | |
Poorly Differentiated | X | 1 |
Respiratory Epithelium, Adenoma, | | |
Papillary | | 1 |
Respiratory Epithelium, Squamous | | |
Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + A + + + + + + + + + + A + + A + A + + +| 42 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 8 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05080-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:11
__________________________________________________________________________________________________________________________________
| 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5| |
DAY ON TEST | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2| |
| 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
OSBORNE MENDEL RATS MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
10 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | + + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + A + + + + A + + +| 44 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
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