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TDMS Study 05080-01 Pathology Tables

NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11




       Facility:  Battelle Northwest

       Chemical CAS #:  106-92-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|             
                                           | 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  M  +  +  +  +  +  A  M  +  +  M  M  M  +  +  +  M  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  A  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  A  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                              +                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                X                                                        X|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Pheochromocytoma Benign              |             X                                X                    X     X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X  X                       X                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  M  M  +  +  M  M  M  +  M  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Pars Distalis, Adenoma               |       X     X     X     X  X           X     X  X     X  X     X  X  X  X|             
      Pars Distalis, Carcinoma             |                                  X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      C-Cell, Adenoma                      |       X           X                                   X        X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|             
                                           | 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      C-Cell, Carcinoma                    |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |          X                                                               |             
      Granulosa-Theca Tumor Benign         |                   X                                                      |             
      Hamartoma                            |                   X                                                      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Polyp Stromal                        |                               X                 X                       X|             
      Sarcoma Stromal                      |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +|             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  +  M  M  +  M  +  M  +  +  +  M  +  M  M  +  M  M  +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Thymus               |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  M  A  +|             
      Basosquamous Tumor Malignant         |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                        X                                 |             
      Fibroadenoma                         | X     X        X  X        X     X  X                    X     X     X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 2| 3| 2| 7| 0| 0| 3| 8| 3| 6| 3| 3| 3| 4| 3| 3| 4| 0| 3| 3| 3|             
                                           | 7| 9| 7| 7| 2| 7| 3| 8| 0| 5| 7| 3| 7| 9| 7| 7| 7| 1| 7| 7| 7| 5| 6| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                  X                                       |             
      Granular Cell Tumor Benign           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Malignant,        |                                                                          |             
          Metastatic, Thymus               |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          | +                 +           +                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7|            |
                             DAY ON TEST   | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2|            |
                                           | 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  M  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  A  M  +  M  M  +|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M  +  +  +  +  A  +  M  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  A|  41        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                      X                             X                     |          2 |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Neoplastic Nodule                    |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                   +      |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                   +      |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |       X                                                                  |          3 |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Pheochromocytoma Benign              |                   X                                            X         |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |          X                                                               |          4 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  M  M  +  +  I  M  M  M  +  M  +  M  M  +  M  M  +  M  +|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7|            |
                             DAY ON TEST   | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2|            |
                                           | 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               | X  X     X  X     X  X           X     X        X           X  X        X|         26 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      C-Cell, Adenoma                      |    X        X                    X     X           X                    X|         10 |
      C-Cell, Adenoma, Multiple            |                                              X                           |          1 |
      C-Cell, Carcinoma                    |                         X                          X  X                  |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Granulosa-Theca Tumor Benign         |                                                                          |          1 |
      Hamartoma                            |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                          X              X|          2 |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Polyp Stromal                        |    X                                X  X        X        X     X        X|         10 |
      Sarcoma Stromal                      |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +|  34        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Thymus               |                            X                                             |          1 |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|  43        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +|  41        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 5| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 2| 4| 7|            |
                             DAY ON TEST   | 7| 0| 2| 3| 3| 1| 6| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 7| 3| 0| 7| 2|            |
                                           | 9| 5| 1| 7| 7| 1| 7| 7| 7| 9| 7| 7| 7| 0| 7| 7| 7| 7| 7| 4| 8| 7| 7| 4| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Basosquamous Tumor Malignant         |                            X                                             |          1 |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |    X                                                                     |          2 |
      Fibroadenoma                         | X        X  X  X  X                 X        X  X  X     X  X        X  X|         23 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Granular Cell Tumor Benign           | X                                                     X                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basosquamous Tumor Malignant,        |                                                                          |            |
          Metastatic, Thymus               |                            X                                             |          1 |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                      +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  M  M  +  M  M  +  M  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  A  M  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                    X|             
      Lymphoma Malignant                   |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Adenoma                              |                      X     X                                X  X         |             
      Adenoma, Multiple                    |                                                                          |             
      Lymphoma Malignant                   |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                      X   |             
      Pheochromocytoma Benign              |    X        X                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  M  M  +  +  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X  X  X  X     X     X  X  X              X  X        X  X  X  X  X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |             X  X              X              X              X  X        X|             
      C-Cell, Adenoma, Multiple            | X                                                                 X      |             
      C-Cell, Carcinoma                    |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
      Sarcoma Stromal, Metastatic, Uterus  |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Polyp Stromal                        |       X     X                 X           X                 X  X     X   |             
      Sarcoma                              |                                                       X                  |             
      Sarcoma Stromal                      |          X                                         X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  M  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 1| 5| 5| 3| 7| 6| 4| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 7| 3| 6| 3| 6| 5| 7| 1| 3| 4| 0| 3| 3| 3| 3| 3| 2| 3|             
                                           | 8| 8| 8| 8| 8| 8| 8| 4| 8| 9| 5| 4| 0| 9| 8| 8| 2| 8| 1| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |       X                       X                          X               |             
      Adenocarcinoma, Multiple             |                                           X                              |             
      Fibroadenoma                         |    X  X  X  X  X           X           X        X     X                 X|             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                          |             
      Sarcoma                              |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                           X                              |             
      Carcinoma Adenosquamous              |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
      Sarcoma, Metastatic, Uterus          |                                                       X                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Respiratory Epithelium, Adenoma,     |                                                                          |             
           Papillary                       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                    +      |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Liposarcoma                          |                                                                X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                      X   |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3|            |
                                           | 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  M  +  M  +  M  +  +  +  M  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                 X                        |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Squamous Cell Carcinoma              |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                       X                  |          5 |
      Adenoma, Multiple                    |                                                          X               |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3|            |
                                           | 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Carcinoma                            |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  M  M  M|  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  +  +  +  +  A  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Pars Distalis, Adenoma               |    X  X     X  X     X                    X  X              X        X  X|         26 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  I  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      C-Cell, Adenoma                      |       X        X     X              X           X                 X  X   |         14 |
      C-Cell, Adenoma, Multiple            |                               X  X                          X            |          5 |
      C-Cell, Carcinoma                    | X                                                                        |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma Stromal, Metastatic, Uterus  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Polyp Stromal                        |                X  X                    X  X                              |         11 |
      Sarcoma                              |                                                                          |          1 |
      Sarcoma Stromal                      |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +|  39        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  45        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3|            |
                                           | 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |    X                                                                 X   |          5 |
      Adenocarcinoma, Multiple             |                                                                          |          1 |
      Fibroadenoma                         |          X     X                             X  X  X     X     X         |         17 |
      Fibroadenoma, Multiple               |       X                                               X                  |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibroma                              |                                                                X         |          1 |
      Sarcoma                              |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Carcinoma Adenosquamous              |                      X                                                   |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma, Metastatic, Uterus          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Respiratory Epithelium, Adenoma,     |                                                                          |            |
           Papillary                       |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 3| 7| 3| 7| 5| 7| 7| 7| 7| 5| 7| 4| 7| 5| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 2| 4| 3| 3| 3| 3| 3| 9| 3| 4| 3| 3| 3| 3| 6| 3| 7| 3| 7| 3| 3| 3| 5| 3|            |
                                           | 8| 3| 2| 8| 8| 8| 9| 8| 6| 8| 7| 8| 8| 8| 8| 9| 8| 1| 8| 9| 8| 8| 8| 9| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   3        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Liposarcoma                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|             
                                           | 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  +  +  +  M  +  +  +  M  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  I  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                            X                                             |             
      Adenoma                              |                                                                   X      |             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +                                         +   |             
      Adenocarcinoma, Metastatic, Uterus   |                      X     X                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                      X     X                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                      X                                                   |             
      Glandular, Adenocarcinoma,           |                                                                          |             
          Metastatic, Uterus               |                            X                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                            X                                             |             
      Adenoma                              |                   X                                            X         |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Pheochromocytoma Benign              |                                  X     X                       X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|             
                                           | 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign, Multiple    |          X                                                           X  X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  M  +  M  M  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X     X        X           X  X     X                 X               |             
      Pars Distalis, Carcinoma             |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |    X                          X  X                       X  X     X      |             
      C-Cell, Adenoma, Multiple            |                                                                          |             
      C-Cell, Carcinoma                    |                                                    X        X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                      X     X                                             |             
      Embryonal Carcinoma                  |                                                                          |             
      Granulosa Cell Tumor Malignant       |                                     X                                    |             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Uterus                          |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                      X     X                                             |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Polyp Stromal                        |                                                          X     X         |             
      Sarcoma Stromal                      |                                                                          |             
      Squamous Cell Carcinoma              |          X                                                               |             
      Endometrium, Adenoma, Papillary      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                      X     X                                             |             
      Lymphoma Malignant                   | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|             
      Lymphoma Malignant                   | X                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|             
                                           | 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma, Metastatic, Uterus   |                      X     X                                             |             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenocarcinoma, Metastatic, Uterus   |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |          X  X                                                            |             
      Fibroadenoma                         |    X  X                                   X                 X     X      |             
      Fibroadenoma, Multiple               |                                                    X                     |             
      Fibrosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +     +                                             |             
      Diaphragm, Adenocarcinoma,           |                                                                          |             
          Metastatic, Uterus               |                      X     X                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                      X     X                                             |             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                            X                                             |             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 7| 7| 7| 5| 7| 7| 6| 0| 5| 7| 7| 7| 7| 4| 6| 7| 7| 2| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 3| 3| 7| 0| 3| 5| 3| 7| 3| 3| 3| 3| 0| 6| 3| 1| 2| 3| 2| 2| 3| 3| 3|             
                                           | 1| 9| 9| 9| 0| 5| 9| 2| 1| 8| 9| 9| 9| 9| 9| 8| 9| 5| 0| 9| 4| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Cell Type                        |                                                                          |             
      Nephroblastoma                       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  M  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  45        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Adenoma                              |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|  46        |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Glandular, Adenocarcinoma,           |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I|  44        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Adenoma                              |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  A  +  +|  47        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
      Pheochromocytoma Benign              |                                                                          |          3 |
      Pheochromocytoma Benign, Multiple    |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  +  +  M  +  M  M  M  +  +  M  +  +  M  M  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Pars Distalis, Adenoma               | X  X  X     X     X        X  X  X           X  X        X  X           X|         20 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      C-Cell, Adenoma                      | X  X  X     X                                                            |         10 |
      C-Cell, Adenoma, Multiple            |                                  X        X                              |          2 |
      C-Cell, Carcinoma                    |             X                                X                           |          4 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  A  M  +|  43        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          2 |
      Embryonal Carcinoma                  |                                     X                                    |          1 |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Uterus                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                              X                           |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
      Polyp Stromal                        | X     X           X        X  X              X              X            |          9 |
      Sarcoma Stromal                      |                X                                                         |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Endometrium, Adenoma, Papillary      |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  M  +|  43        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +|  44        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +|  43        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |          X                 X                                             |          4 |
      Fibroadenoma                         | X  X  X     X  X  X  X  X     X           X              X  X  X     X  X|         20 |
      Fibroadenoma, Multiple               |                                                       X                  |          2 |
      Fibrosarcoma                         |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Diaphragm, Adenocarcinoma,           |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 2| 7| 7| 7| 3| 7| 7| 7| 6| 5| 7| 6| 7| 7| 6| 5| 6| 7| 7| 3| 3| 7|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 2| 3| 6| 3| 3| 3| 5| 7| 3| 9| 3| 3| 4| 7| 9| 3| 2| 3| 3| 3|            |
                                           | 9| 9| 9| 9| 3| 9| 9| 7| 9| 9| 9| 8| 9| 9| 4| 9| 9| 8| 0| 4| 9| 9| 0| 2| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS FEMALE              | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          | +                                                                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
      Nephroblastoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  47        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                    X                     |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|             
                                           | 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  +  +  +  +  +  M  M  M  +  +  M  M  +  A  M  M  M  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  A  I  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  A  A  A  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  A  +  +  A  A  A  A  M  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  +  +  +  +  A  A  A  +  +  A  +  +  A  A  A  A  A  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  +  +  +  A  A  A  +  +  A  +  +  A  A  A  A  A  +  +  +  A  +  +|             
      Adenocarcinoma, Mucinous             |                               X                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |             X                                                            |             
      Squamous Cell Papilloma              |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +              +                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
      Carcinoma                            |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
      Pheochromocytoma Malignant           |       X                                                        X        X|             
      Pheochromocytoma Malignant, Multiple |                                                             X            |             
      Pheochromocytoma Benign              |    X                                X                                   X|             
      Pheochromocytoma Benign, Multiple    |                X                                                         |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|             
                                           | 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  M|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X                                   X              X                 X|             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  +  A  +  +|             
      C-Cell, Adenoma                      |       X     X  X                    X                                   X|             
      C-Cell, Carcinoma                    |                X                       X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +                       +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | M  +  M  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  M  +  +  +  M  M  +  +  +  +  +  M  M  +  A  +  +  +  +  M  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
      Thymoma Malignant                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|             
                                           | 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  +  +  +  +  M  +  +  +  +  A  +  M  M  M  M  +  M  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Fibroma                              |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Granular Cell Tumor Benign |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | A  A  +  +  +  +  +  A  +  +  +  A  +  +  A  A  A  +  A  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  A  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic                       |                                                                X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | A  A  +  +  +  +  +  A  +  +  +  A  +  +  A  A  A  +  A  +  +  +  A  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |    +  +  +  +  +              +        +  +        +        +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Adenoma, Multiple                    |                                                          X               |             
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 6| 7| 7| 7| 4| 6| 4| 6| 7| 5| 5| 7| 6| 5| 5| 5| 5| 7| 6| 6| 6| 4| 7|             
                             DAY ON TEST   | 7| 3| 9| 3| 3| 3| 7| 0| 4| 4| 3| 9| 8| 3| 5| 6| 7| 9| 7| 3| 8| 5| 6| 0| 3|             
                                           | 2| 1| 8| 7| 7| 7| 7| 7| 5| 2| 7| 0| 6| 3| 8| 4| 9| 9| 8| 7| 4| 7| 1| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5|            |
                             DAY ON TEST   | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4|            |
                                           | 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  A  +  +  A  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  M  A  +  +  A  +  +  +  +  M  M  M  M  A  A  M  +  A  M  +  M  M  M|  23        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  A  +  +  A  A  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +  +  A  +  +  +  +  A  +  +  +  A  +  A  +  A  +  +  A  A  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  A  +  +  +  +  A  +  +  +  A  A  A  +  A  +  +  A  A  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  A  +  +  A  +  A  A  A  +  A  A  A  +  A  A  +  A  A  A|  24        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  A  +  +  A  +  A  A  A  +  A  A  A  +  A  A  +  A  A  A|  24        |
      Adenocarcinoma, Mucinous             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant                   |                                     X                                    |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  I  +  +  M  +  +  +  +  +  +|  45        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Pheochromocytoma Malignant           |                X                                            X            |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5|            |
                             DAY ON TEST   | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4|            |
                                           | 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant, Multiple |    X                                                                     |          2 |
      Pheochromocytoma Benign              | X           X           X     X              X                    X      |          9 |
      Pheochromocytoma Benign, Multiple    |                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  M  +  M  +|  36        |
      Adenoma                              |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  47        |
      Pars Distalis, Adenoma               | X  X     X        X     X        X              X                        |         11 |
      Pars Distalis, Carcinoma             |                      X        X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  A  +  +  +  +  +|  43        |
      C-Cell, Adenoma                      |          X        X                                            X         |          8 |
      C-Cell, Carcinoma                    |                                                 X     X        X         |          5 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  40        |
      Carcinoma, Metastatic, Thyroid Gland |                                                       X                  |          1 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant                   |                                     X                                    |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|  44        |
      Lymphoma Malignant                   |                                     X                                    |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5|            |
                             DAY ON TEST   | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4|            |
                                           | 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant                   |                                     X                                    |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Thymoma Malignant                    |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  M  +  +  M  +  +  +  +  M  M  +  M  M  +  +  M  M  +  M  +  +  M|  27        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma, Metastatic, Thyroid Gland |                                                       X                  |          1 |
      Fibroma                              |                                           X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Meninges, Granular Cell Tumor Benign |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  A  +  +  +  +  A  +  +|  39        |
      Carcinoma, Metastatic, Thyroid Gland |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +|  42        |
      Carcinoma, Metastatic, Thyroid Gland |                                                       X                  |          1 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant                   |                                     X                                    |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  40        |
      Carcinoma, Metastatic, Thyroid Gland |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 4| 5| 3| 6| 7| 4| 7| 6| 6| 7| 6| 4| 5|            |
                             DAY ON TEST   | 3| 3| 0| 6| 2| 3| 1| 1| 3| 9| 3| 9| 4| 4| 2| 8| 3| 7| 3| 3| 0| 1| 0| 8| 4|            |
                                           | 7| 7| 6| 6| 3| 7| 0| 9| 7| 0| 7| 3| 9| 8| 7| 3| 5| 9| 7| 5| 4| 9| 9| 5| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +        +     A                     |   3        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          | +  +              +           +                       +  +               |  19        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                X         |          1 |
      Adenoma, Multiple                    |                                                                          |          1 |
      Carcinoma, Metastatic, Thyroid Gland |                                                       X                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                     X                                    |          1 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|             
                             DAY ON TEST   | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|             
                                           | 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  M  +  +  A  +  +  +  M  M  +  M  +  M  +  +  +  M  +  A  +  +  M  M  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  A  +  +  A  +  +  +  A  +  +  A  +  A  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  A  +  A  +  +  +  A  M  +  A  +  A  +  +  +  +  +  A  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  +  A  +  +  +  A  M  +  A  +  A  +  +  +  +  +  A  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Squamous Cell Carcinoma              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Pheochromocytoma Benign              |                X                             X           X  X            |             
      Pheochromocytoma Benign, Multiple    |                   X  X                             X                    X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|             
                             DAY ON TEST   | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|             
                                           | 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Pars Distalis, Adenoma               |                      X                          X  X  X  X              X|             
      Pars Intermedia, Adenoma             |                   X                             X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                X           X  X                                X        X|             
      C-Cell, Adenoma, Multiple            |                                           X                              |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Seminal Vesicle |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  M  +  M  M  M  M  M  +  M  +  +  M  M  +  M  +  M  +  +  M  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                             X            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|             
                             DAY ON TEST   | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|             
                                           | 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                        X                                 |             
      Keratoacanthoma                      |                                                                         X|             
      Sarcoma                              |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Schwannoma Malignant,       |                                                                          |             
          Metastatic, Brain                |                                                                X         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Sarcoma, Metastatic, Skin            |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                             X            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
      Sarcoma, Metastatic, Skin            |                                                                      X   |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Brain                           |                                                                X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Harderian     |                                                                          |             
          Gland                            |                                                             X            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 6| 7| 7| 7| 4| 6| 7| 5| 6| 5| 7| 6| 7| 5| 7| 7| 6| 6| 4| 4| 6|             
                             DAY ON TEST   | 2| 5| 8| 3| 5| 3| 3| 2| 9| 2| 3| 2| 8| 6| 3| 6| 3| 9| 3| 0| 7| 6| 6| 4| 8|             
                                           | 1| 4| 3| 8| 5| 8| 8| 2| 9| 4| 8| 6| 9| 5| 8| 8| 8| 1| 8| 8| 7| 2| 6| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +  +            |             
      Carcinoma                            |                                                             X            |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |          +  +  +     +        +     +     +     +  +  +  +     +         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Sarcoma, Metastatic, Seminal Vesicle |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4|            |
                             DAY ON TEST   | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1|            |
                                           | 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  M  M  +  M  M  M  M  +  +  +  A  +  M  M  A  M  +  M  +  +  M  A  M  M|  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  A  +  A  +  A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  A  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  A  +  A  A  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  A  +  A  A  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  A  +  A  A  A  A  +  M  +  A  +  +  +  A  A  +  +  +  +  A  A  +  +|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  A  +  A  A  A  A  +  A  +  A  +  +  +  A  A  +  +  +  +  A  A  +  A|  27        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                               X                                          |          1 |
      Hepatocellular Carcinoma             |                                                                   X      |          1 |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                       X                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  46        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  A  +  +  A  +  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  43        |
      Squamous Cell Carcinoma              |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                       X                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4|            |
                             DAY ON TEST   | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1|            |
                                           | 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  A  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Pheochromocytoma Benign              |                                  X                       X           X   |          7 |
      Pheochromocytoma Benign, Multiple    |                            X        X     X                              |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  M  +  M  I  +  +  +  M  M  M  +  +  M  +  +  +  +  +  M  M  +|  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  A  I  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                       X                  |          1 |
      Pars Distalis, Adenoma               |                      X     X                 X           X     X  X      |         12 |
      Pars Intermedia, Adenoma             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      C-Cell, Adenoma                      |                         X  X                    X     X                  |          9 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
      C-Cell, Carcinoma                    |                                     X                                    |          1 |
      Follicular Cell, Adenoma             |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant                   |                                                       X                  |          1 |
      Sarcoma, Metastatic, Seminal Vesicle |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                       X                  |          1 |
      Sarcoma                              |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant                   |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant                   |                                                       X                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4|            |
                             DAY ON TEST   | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1|            |
                                           | 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M|  44        |
      Renal, Lymphoma Malignant Histiocytic|                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  A  M  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  M  +  M|  29        |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  A  +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  M|  40        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                       X                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  A  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangioma                           |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          1 |
      Sarcoma                              |                                        X                                 |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Schwannoma Malignant,       |                                                                          |            |
          Metastatic, Brain                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  A  A  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 4| 5| 7| 4| 5| 5| 5| 7| 6| 7| 6| 7| 5| 5| 6| 5| 6| 7| 7| 6| 6| 6| 5| 4|            |
                             DAY ON TEST   | 3| 7| 6| 3| 4| 7| 7| 9| 3| 7| 3| 5| 3| 2| 8| 2| 3| 3| 0| 3| 3| 0| 5| 0| 1|            |
                                           | 1| 5| 0| 8| 3| 8| 9| 9| 8| 0| 8| 0| 8| 0| 6| 6| 1| 5| 4| 8| 8| 6| 9| 0| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant                   |                                                       X                  |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Brain                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Carcinoma, Metastatic, Harderian     |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |          +              +     +  +  +        +           +  +     +      |  21        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant                   |                                                       X                  |          1 |
      Sarcoma, Metastatic, Seminal Vesicle |                                                             X            |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                       X                  |          1 |
      Lymphoma Malignant Histiocytic       |                                                    X                     |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|             
                             DAY ON TEST   | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|             
                                           | 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  M  M  M  M  M  +  M  M  +  +  M  +  A  +  A  +  A  M  +  A  +  M  M  M|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  A|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  A  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  +  A  A  +  +  +  A  +  +  +  +  M  +  +  +  A  +  +  +  +  A  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  +  A  A  A  +  A  +  +  A  +  +  A  +  A  +  A  M  +  A  +  A  +  A|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  A  A  A  +  A  +  +  A  +  +  A  +  +  +  A  +  +  A  +  A  +  A|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  M|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +|             
      Squamous Cell Carcinoma              |                                           X                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|             
                             DAY ON TEST   | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|             
                                           | 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                        X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Pheochromocytoma Malignant           |                                           X                              |             
      Pheochromocytoma Malignant, Multiple |                                                                          |             
      Pheochromocytoma Benign              |                X                       X     X           X     X  X      |             
      Pheochromocytoma Benign, Multiple    |    X                                X                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  M  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Pars Distalis, Adenoma               |    X              X        X                 X              X     X      |             
      Pars Intermedia, Adenoma             |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      C-Cell, Adenoma                      | X                 X                                            X         |             
      C-Cell, Adenoma, Multiple            |                                           X                              |             
      C-Cell, Carcinoma                    |                                                          X  X            |             
      Follicular Cell, Adenoma             |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  +  M|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|             
                             DAY ON TEST   | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|             
                                           | 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  M|             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                       X                  |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  A  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  +  M|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  A  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  A  +  M|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Uncertain     |                                                                          |             
          Primary Site                     |                                                                         X|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  M  M  M  M  M  M|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                     X                                    |             
      Lip, Squamous Cell Carcinoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Squamous Cell Carcinoma,    |                                                                          |             
           Metastatic, Nose                |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Oligodendroglioma Malignant          |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 6| 1| 4| 5| 7| 5| 3| 6| 6| 5| 6| 6| 7| 6| 7| 5| 5| 7| 6| 6| 5| 2| 5|             
                             DAY ON TEST   | 0| 7| 1| 0| 8| 9| 3| 3| 0| 9| 7| 9| 5| 7| 3| 6| 3| 2| 9| 3| 8| 3| 6| 6| 7|             
                                           | 0| 0| 7| 8| 2| 9| 9| 7| 0| 4| 4| 2| 2| 8| 9| 6| 9| 4| 0| 9| 1| 4| 8| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
      Olfactory Epithelium, Adenocarcinoma,|                                                                          |             
           Poorly Differentiated           |                                                                          |             
      Respiratory Epithelium, Adenoma,     |                                                                          |             
           Papillary                       |                   X                                                      |             
      Respiratory Epithelium, Squamous     |                                                                          |             
          Cell Carcinoma                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +  +  +            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |       M           +                 +  +  +                    +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                       X                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  A  A  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  M  +  M  M  A  +  M  M  M  A  A  +  M  +  M  M  +  +  M  +  M  A  M  M|  15        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  A  +  +  A  A  +  A  +  +  +  +  +  +  +  A  A  +  +  A  +  A  A  +  +|  34        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  M  A  +  +  A  +  A  A  +  +|  38        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  A  A  +  +  +  +  A  +  +  +  +  A  A  +  +  A  +  A  A  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  A  A  +  +  +  +  A  +  +  +  +  A  A  +  +  A  +  A  A  +  +|  33        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +  +  M  A  +  A  +  A  A  A  +  +  +  A  A  +  +  A  +  A  A  +  +|  23        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  +  +  A  A  +  A  +  A  A  +  +  +  +  A  A  A  +  A  +  A  A  +  +|  25        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                          X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +|  44        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  44        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                          X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                          X                                    |          2 |
      Pheochromocytoma Malignant           |    X                                               X                     |          3 |
      Pheochromocytoma Malignant, Multiple |                                                             X            |          1 |
      Pheochromocytoma Benign              |                      X        X     X           X        X           X   |         12 |
      Pheochromocytoma Benign, Multiple    |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  45        |
      Adenoma                              |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  M  M  M  +  +  M  +  M  +  +  +  +  +  +|  38        |
      Adenoma                              |                            X                             X               |          2 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  A  +  +  +  +  +  +  +  I  +  +  +  +  +  A  M  A  +  +  +|  44        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
      Pars Distalis, Adenoma               |    X                       X     X        X  X        X              X   |         13 |
      Pars Intermedia, Adenoma             |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      C-Cell, Adenoma                      |    X  X     X                                X     X  X        X         |         10 |
      C-Cell, Adenoma, Multiple            |                                     X                                    |          2 |
      C-Cell, Carcinoma                    |                                  X                                       |          3 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  I  M  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  A  +  +  +|  44        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  M  M  +|  38        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                          X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  42        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                          X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  46        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                          X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  A  +  +  +  +  +  M  +  +|  44        |
      Carcinoma, Metastatic, Uncertain     |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                            X                                             |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  M  +  M  +  +  M  M  M  +|  32        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroadenoma                         |                         X                                               X|          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibroma                              |                                                                          |          1 |
      Lip, Squamous Cell Carcinoma         |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cranium, Squamous Cell Carcinoma,    |                                                                          |            |
           Metastatic, Nose                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Oligodendroglioma Malignant          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +|  45        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                          X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  A  +  A  +  +  +|  43        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
      Olfactory Epithelium, Adenocarcinoma,|                                                                          |            |
           Poorly Differentiated           |                                        X                                 |          1 |
      Respiratory Epithelium, Adenoma,     |                                                                          |            |
           Papillary                       |                                                                          |          1 |
      Respiratory Epithelium, Squamous     |                                                                          |            |
          Cell Carcinoma                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +  +                                 |   2        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +     +     +     +     +                                    |   8        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                     X                                    |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05080-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 5| 7| 5| 6| 5| 7| 5| 6| 5| 6| 7| 6| 4| 7| 6| 5| 6| 6| 3| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 8| 9| 3| 8| 1| 2| 3| 8| 2| 8| 5| 3| 4| 3| 3| 0| 8| 6| 4| 0| 3| 0| 5| 7| 2|            |
                                           | 2| 3| 9| 6| 0| 3| 9| 8| 8| 0| 3| 0| 2| 4| 9| 5| 5| 2| 2| 3| 9| 1| 9| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   OSBORNE MENDEL RATS MALE                | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                    +           +         |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                          X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  44        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                            X                                             |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |          X                          X                                    |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
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