TDMS Study 05080-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) ALLYL GLYCIDYL ETHER NTP Experiment-Test: 05080-01 Report: PEIRPT05 Study Type: CHRONIC Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 Facility: Battelle Northwest Chemical CAS #: 106-92-3 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 ____________________________________________________________________________________________________________________________________ OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Dead 9 8 5 Moribund 17 12 20 Survivors Terminal Sacrifice 24 30 25 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Ileum (40) (43) (45) Liver (50) (48) (49) Adenocarcinoma, Metastatic, Uterus 1 (2%) Adenoma 2 (4%) 3 (6%) 1 (2%) Neoplastic Nodule 1 (2%) Mesentery (1) (3) Adenocarcinoma, Metastatic, Uterus 2 (67%) Pancreas (50) (48) (49) Adenocarcinoma, Metastatic, Uterus 2 (4%) Salivary Glands (48) (47) (48) Stomach, Forestomach (50) (47) (46) Squamous Cell Carcinoma 1 (2%) Squamous Cell Papilloma 1 (2%) Glandular, Adenocarcinoma, Metastatic, Uterus 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (49) (50) Adenocarcinoma, Metastatic, Uterus 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (50) (49) (49) Adenocarcinoma, Metastatic, Uterus 1 (2%) Adenoma 3 (6%) 5 (10%) 2 (4%) Adenoma, Multiple 1 (2%) Adrenal Gland, Medulla (49) (48) (47) Pheochromocytoma Benign 6 (12%) 2 (4%) 3 (6%) Pheochromocytoma Benign, Multiple 3 (6%) Islets, Pancreatic (50) (48) (48) Adenoma 4 (8%) Page 2 NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 ____________________________________________________________________________________________________________________________________ OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Carcinoma 1 (2%) Pituitary Gland (50) (45) (48) Pars Distalis, Adenoma 26 (52%) 26 (58%) 20 (42%) Pars Distalis, Carcinoma 1 (2%) 1 (2%) Thyroid Gland (49) (47) (47) C-Cell, Adenoma 10 (20%) 14 (30%) 10 (21%) C-Cell, Adenoma, Multiple 1 (2%) 5 (11%) 2 (4%) C-Cell, Carcinoma 4 (8%) 2 (4%) 4 (9%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (43) (45) (43) Ovary (49) (48) (49) Adenocarcinoma, Metastatic, Uterus 2 (4%) Embryonal Carcinoma 1 (2%) Granulosa Cell Tumor Malignant 1 (2%) Granulosa Cell Tumor Benign 1 (2%) Granulosa-Theca Tumor Benign 1 (2%) Hamartoma 1 (2%) Sarcoma Stromal, Metastatic, Uterus 1 (2%) Squamous Cell Carcinoma, Metastatic, Uterus 1 (2%) Uterus (50) (50) (50) Adenocarcinoma 2 (4%) 3 (6%) Polyp Stromal 10 (20%) 11 (22%) 9 (18%) Sarcoma 1 (2%) Sarcoma Stromal 1 (2%) 2 (4%) 1 (2%) Squamous Cell Carcinoma 1 (2%) Endometrium, Adenoma, Papillary 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (49) (45) (48) Lymph Node (48) (50) (49) Lymph Node, Bronchial (34) (39) (43) Adenocarcinoma, Metastatic, Uterus 2 (5%) Basosquamous Tumor Malignant, Metastatic, Thymus 1 (3%) Lymph Node, Mandibular (43) (45) (44) Spleen (50) (48) (49) Adenocarcinoma, Metastatic, Uterus 2 (4%) Page 3 NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 ____________________________________________________________________________________________________________________________________ OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Thymus (41) (47) (43) Adenocarcinoma, Metastatic, Uterus 1 (2%) Basosquamous Tumor Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) Adenocarcinoma 2 (4%) 5 (10%) 4 (8%) Adenocarcinoma, Multiple 1 (2%) Fibroadenoma 23 (46%) 17 (34%) 20 (40%) Fibroadenoma, Multiple 2 (4%) 2 (4%) Fibrosarcoma 1 (2%) Skin (48) (49) (49) Fibroma 1 (2%) Sarcoma 2 (4%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (2) Diaphragm, Adenocarcinoma, Metastatic, Uterus 2 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (49) (50) (50) Carcinoma, Metastatic, Pituitary Gland 1 (2%) Granular Cell Tumor Benign 2 (4%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (50) (49) Adenocarcinoma, Metastatic, Mammary Gland 1 (2%) Adenocarcinoma, Metastatic, Uterus 2 (4%) Basosquamous Tumor Malignant, Metastatic, Thymus 1 (2%) Carcinoma Adenosquamous 1 (2%) Sarcoma, Metastatic, Uterus 1 (2%) Nose (49) (48) (47) Respiratory Epithelium, Adenoma, Papillary 1 (2%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 ____________________________________________________________________________________________________________________________________ OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (48) (49) Adenocarcinoma, Metastatic, Uterus 1 (2%) Liposarcoma 1 (2%) Nephroblastoma 1 (2%) Urinary Bladder (49) (47) (47) Adenocarcinoma, Metastatic, Uterus 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Lymphoma Malignant 1 (2%) 1 (2%) Lymphoma Malignant Histiocytic 1 (2%) Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 ____________________________________________________________________________________________________________________________________ OSBORNE MENDEL RATS FEMALE CONTROL 5 PPM 10 PPM FEMALE FEMALE FEMALE ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 43 47 44 Total Primary Neoplasms 103 107 94 Total Animals with Benign Neoplasms 40 44 37 Total Benign Neoplasms 91 88 74 Total Animals with Malignant Neoplasms 12 19 17 Total Malignant Neoplasms 12 19 20 Total Animals with Metastatic Neoplasms 2 3 3 Total Metastatic Neoplasm 3 3 22 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 ____________________________________________________________________________________________________________________________________ OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM MALE MALE MALE ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Dead 27 27 29 Moribund 11 12 13 Survivors Moribund 1 Terminal Sacrifice 12 10 8 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (23) (21) (15) Intestine Large, Colon (39) (38) (34) Intestine Large, Rectum (40) (42) (38) Intestine Small, Duodenum (33) (37) (33) Intestine Small, Ileum (24) (27) (23) Intestine Small, Jejunum (24) (27) (25) Adenocarcinoma, Mucinous 1 (4%) Liver (49) (49) (47) Adenoma 1 (2%) Hepatocellular Carcinoma 1 (2%) Pancreas (48) (48) (44) Salivary Glands (50) (46) (47) Carcinoma, Metastatic, Harderian Gland 1 (2%) Stomach, Forestomach (45) (43) (44) Squamous Cell Carcinoma 1 (2%) 2 (5%) 1 (2%) Squamous Cell Papilloma 1 (2%) Stomach, Glandular (48) (48) (46) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland, Cortex (48) (48) (48) Adenoma 1 (2%) 1 (2%) 2 (4%) Carcinoma 1 (2%) Adrenal Gland, Medulla (47) (47) (47) Pheochromocytoma Malignant 5 (11%) 3 (6%) Pheochromocytoma Malignant, Multiple 2 (4%) 1 (2%) Page 7 NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 ____________________________________________________________________________________________________________________________________ OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM MALE MALE MALE ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont Pheochromocytoma Benign 9 (19%) 7 (15%) 12 (26%) Pheochromocytoma Benign, Multiple 1 (2%) 7 (15%) 2 (4%) Bilateral, Pheochromocytoma Benign 1 (2%) Islets, Pancreatic (48) (48) (45) Adenoma 2 (4%) 1 (2%) Parathyroid Gland (36) (30) (38) Adenoma 1 (3%) 2 (5%) Pituitary Gland (47) (46) (44) Pars Distalis, Adenoma 11 (23%) 12 (26%) 13 (30%) Pars Distalis, Carcinoma 2 (4%) Pars Intermedia, Adenoma 2 (4%) 2 (5%) Thyroid Gland (43) (46) (46) C-Cell, Adenoma 8 (19%) 9 (20%) 10 (22%) C-Cell, Adenoma, Multiple 1 (2%) 2 (4%) C-Cell, Carcinoma 5 (12%) 1 (2%) 3 (7%) Follicular Cell, Adenoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (49) (48) (46) Prostate (49) (49) (46) Sarcoma, Metastatic, Seminal Vesicle 1 (2%) Seminal Vesicle (49) (49) (45) Sarcoma 1 (2%) Testes (49) (49) (49) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (46) (48) (44) Lymph Node (48) (44) (45) Lymph Node, Bronchial (40) (29) (38) Carcinoma, Metastatic, Thyroid Gland 1 (3%) Lymph Node, Mandibular (44) (40) (42) Carcinoma, Metastatic, Harderian Gland 1 (3%) Spleen (50) (49) (46) Thymus (46) (46) (44) Carcinoma, Metastatic, Uncertain Primary Site 1 (2%) Thymoma Malignant 1 (2%) ____________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 ____________________________________________________________________________________________________________________________________ OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM MALE MALE MALE ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (27) (40) (32) Fibroadenoma 2 (6%) Skin (49) (49) (49) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Fibroma 2 (4%) 1 (2%) Hemangioma 1 (2%) Keratoacanthoma 1 (2%) Sarcoma 2 (4%) Lip, Squamous Cell Carcinoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (49) Cranium, Schwannoma Malignant, Metastatic, Brain 1 (2%) Cranium, Squamous Cell Carcinoma, Metastatic, Nose 1 (2%) Skeletal Muscle (1) (1) Sarcoma, Metastatic, Skin 1 (100%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) Oligodendroglioma Malignant 1 (2%) Schwannoma Malignant 1 (2%) Meninges, Granular Cell Tumor Benign 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (39) (45) (43) Carcinoma, Metastatic, Thyroid Gland 1 (3%) Lung (42) (48) (45) Carcinoma, Metastatic, Harderian Gland 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Pheochromocytoma Malignant, Metastatic 1 (2%) Sarcoma, Metastatic, Skin 1 (2%) Schwannoma Malignant, Metastatic, Brain 1 (2%) Nose (44) (46) (43) Carcinoma, Metastatic, Harderian Gland 1 (2%) Olfactory Epithelium, Adenocarcinoma, Poorly Differentiated 1 (2%) Respiratory Epithelium, Adenoma, Papillary 1 (2%) Respiratory Epithelium, Squamous Cell Page 9 NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 ____________________________________________________________________________________________________________________________________ OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM MALE MALE MALE ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont Carcinoma 1 (2%) Trachea (40) (45) (42) Carcinoma, Metastatic, Thyroid Gland 1 (3%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (2) (1) (2) Harderian Gland (3) (2) (8) Carcinoma 1 (50%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (48) Adenoma 1 (2%) Adenoma, Multiple 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Urinary Bladder (46) (49) (44) Sarcoma, Metastatic, Seminal Vesicle 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Lymphoma Malignant 1 (2%) 1 (2%) 1 (2%) Lymphoma Malignant Histiocytic 1 (2%) 1 (2%) 1 (2%) Lymphoma Malignant Undifferentiated Cell 1 (2%) 1 (2%) 2 (4%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 10 NTP Experiment-Test: 05080-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC ALLYL GLYCIDYL ETHER Date: 09/10/94 Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 18:51:06 ____________________________________________________________________________________________________________________________________ OSBORNE MENDEL RATS MALE CONTROL 5 PPM 10 PPM MALE MALE MALE ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 30 37 38 Total Primary Neoplasms 59 57 67 Total Animals with Benign Neoplasms 25 31 32 Total Benign Neoplasms 38 45 51 Total Animals with Malignant Neoplasms 18 12 14 Total Malignant Neoplasms 21 12 16 Total Animals with Metastatic Neoplasms 2 4 2 Total Metastatic Neoplasm 7 10 2 Total Animals with Malignant Neoplasms 1 Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 65918-65918/65918 --multipart-boundary--