TDMS Study 05080-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/10/94
EXP: 05080 ALLYL GLYCIDYL ETHER TIME: 19:04:03
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 56666
CONT: N01ES38061 CAS: 106-92-3
PATHOLOGIST: R. RENNE
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/10/94
EXP: 05080 ALLYL GLYCIDYL ETHER TIME: 19:04:03
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 56666
CONT: N01ES38061 CAS: 106-92-3
PATHOLOGIST: R. RENNE
ALLYL GLYCIDYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 327 372 402 445 449 477 479 485 506 548 |
| 548 564 578 579 586 590 593 599 604 607 |
| 609 635 642 657 658 661 666 683 684 690 |
| 698 710 719 719 723 731 733 735 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 39 CENSORED DEATHS 0 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 231 413 443 444 466 475 499 500 520 521 |
| 526 531 554 560 565 578 579 586 591 599 |
| 606 624 626 635 638 638 650 655 659 662 |
| 668 670 677 683 683 689 704 708 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 42 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 108 264 282 300 303 434 482 520 523 524 |
| 537 559 568 570 574 579 580 585 586 588 |
| 590 592 593 599 600 605 610 617 628 634 |
| 642 642 652 653 662 666 674 678 681 694 |
| 701 730 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ALLYL GLYCIDYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 94.0 84.0 82.0 62.0 48.0 24.0 |
| | |
| | |
|5 PPM | 100.0 100.0 98.0 98.0 96.0 88.0 76.0 60.0 40.0 22.0 |
| | |
| | |
|10 PPM | 100.0 98.0 96.0 90.0 90.0 86.0 78.0 48.0 30.0 16.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 5 PPM 10 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 24.0% 22.0% 16.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.124 P=0.592 P=0.138 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 597.1 584.1 562.1 |
|NATURAL DEATHS (C) | (17.5) (16.1) (20.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 630.7 617.7 590.1 |
|(STANDARD ERROR) | (15.8) (15.5) (19.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ALLYL GLYCIDYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 207 269 474 478 521 537 541 569 579 579 |
| 600 611 638 647 667 678 683 690 705 705 |
| 705 722 723 723 734 736 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 164 318 339 396 408 471 547 550 569 579 |
| 579 631 642 642 659 669 674 720 723 735 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 31 220 269 281 330 332 367 409 570 570 |
| 578 579 624 624 648 652 658 668 694 694 |
| 705 715 729 729 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ALLYL GLYCIDYL ETHER
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 96.0 96.0 96.0 92.0 86.0 78.0 72.0 48.0 |
| | |
| | |
|5 PPM | 100.0 98.0 98.0 94.0 90.0 88.0 88.0 78.0 70.0 60.0 |
| | |
| | |
|10 PPM | 98.0 98.0 94.0 88.0 84.0 84.0 84.0 76.0 66.0 50.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 5 PPM 10 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 48.0% 60.0% 50.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.428N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 604.7 550.8 536.4 |
|NATURAL DEATHS (C) | (26.4) (34.7) (39.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 668.2 662.5 636.7 |
|(STANDARD ERROR) | (16.6) (18.9) (24.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ALLYL GLYCIDYL ETHER
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
5 PPM = 2
10 PPM = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
112 +
|
|
| 1 3 2 3 1 1 2
P 96 + 3 3 3 1 12 1
E | 33 3 1 1 221
R | 3 211 2 3
C | 1 21 2 1
E 80 + 223 131
N | 2 2131
T | 22311 1
| 22 11
S 64 + 2 211
U | 3 321 21
R | 33 211 1
V | 33 22 1 1
I 48 + 333 222 11 1
V | 333 2 2 11
A | 33 22 11 1
L | 3 3 222 11
32 + 3 33 22 11 1
| 33 2 22
| 33 3 2 2 11
| 33 3
16 + 33
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 43 obs hidden.
ALLYL GLYCIDYL ETHER
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
5 PPM = 2
10 PPM = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1
| 3 2 1 3 1 2
| 3 1 3 2 2 2 11
| 3 3 2 2 1 1
P 90 + 2 2 1 1
E | 3 3 2 112
R | 3 3 12 11
C | 22
E 80 + 31 1
N | 2 1 1 2
T | 3 1 3211
| 3 21 21
S 70 + 33 211
U | 211
R | 3 321131 22
V | 2 2
I 60 + 33 22
V | 1 31
A | 3 3
L | 1 1
50 + 11
| 1
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 22 obs hidden.
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