TDMS Study 05084-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TURMERIC OLEORESIN
NTP Experiment-Test: 05084-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
Facility: TSI Mason Research
Chemical CAS #: 458-37-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 9 10
Early Deaths
Dead 3 2 7 1
Moribund 7 7 10 7
Accident 1
Survivors
Terminal Sacrifice 37 40 34 41
Dead 1 1
Moribund 1 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (55) (48) (46) (57)
Autolysis 2 (4%) 1 (2%) 3 (7%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 3 (5%)
Intestine Large, Cecum (59) (60) (59) (60)
Autolysis 4 (7%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic Active 1 (2%)
Epithelium, Pigmentation 10 (17%)
Intestine Large, Colon (60) (60) (58) (60)
Autolysis 3 (5%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Epithelium, Pigmentation 6 (10%)
Intestine Large, Rectum (60) (60) (58) (60)
Autolysis 3 (5%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (60) (60) (57) (60)
Autolysis 3 (5%) 1 (2%) 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Small, Ileum (60) (60) (58) (59)
Autolysis 3 (5%) 1 (2%) 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (5%) 1 (2%) 3 (5%)
Epithelium, Hyperplasia 1 (2%)
Epithelium, Pigmentation 9 (15%)
Peyer's Patch, Hyperplasia 1 (2%)
Intestine Small, Jejunum (60) (60) (57) (60)
Autolysis 4 (7%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (3%)
Epithelium, Pigmentation 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Liver (60) (52) (56) (60)
Angiectasis 1 (2%) 1 (2%)
Autolysis 1 (2%)
Basophilic Focus 2 (4%)
Clear Cell Focus 5 (8%) 2 (4%) 3 (5%) 2 (3%)
Eosinophilic Focus 2 (3%) 2 (4%) 8 (14%) 8 (13%)
Fatty Change 1 (2%) 2 (4%) 2 (4%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Infarct 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%) 3 (5%)
Inflammation, Chronic Active 26 (43%) 29 (56%) 27 (48%) 37 (62%)
Mixed Cell Focus 3 (5%) 1 (2%) 2 (4%) 1 (2%)
Necrosis 2 (3%) 12 (23%) 3 (5%)
Necrosis, Coagulative 2 (3%) 2 (4%) 2 (3%)
Oval Cell, Hyperplasia 1 (2%)
Mesentery (7) (8) (5) (4)
Fibrosis 6 (86%) 8 (100%) 5 (100%) 3 (75%)
Hemorrhage 1 (20%) 1 (25%)
Inflammation, Chronic 5 (63%) 2 (40%)
Inflammation, Chronic Active 2 (40%) 3 (75%)
Necrosis 5 (71%) 6 (75%) 3 (60%) 3 (75%)
Necrosis, Coagulative 1 (13%) 2 (40%)
Pancreas (60) (50) (49) (60)
Autolysis 1 (2%)
Cyst 2 (4%) 1 (2%)
Cytoplasmic Alteration 3 (6%) 2 (4%)
Fibrosis 1 (2%) 1 (2%)
Inflammation, Chronic 5 (8%) 4 (7%)
Inflammation, Chronic Active 2 (3%) 1 (2%) 1 (2%)
Acinus, Atrophy 2 (3%) 1 (2%)
Salivary Glands (60) (50) (51) (60)
Parotid Gland, Atrophy 1 (2%)
Parotid Gland, Inflammation, Chronic 3 (5%) 3 (5%)
Sublingual Gland, Inflammation, Chronic 7 (12%) 2 (4%) 4 (7%)
Submandibular Gland, Atrophy 2 (4%)
Submandibular Gland, Inflammation, Chronic 51 (85%) 34 (68%) 31 (61%) 50 (83%)
Stomach, Forestomach (59) (60) (59) (59)
Acanthosis 1 (2%) 2 (3%) 4 (7%)
Hyperkeratosis 1 (2%) 1 (2%) 2 (3%) 4 (7%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Chronic Active 2 (3%) 3 (5%)
Ulcer, Acute 1 (2%)
Stomach, Glandular (60) (60) (59) (59)
Autolysis 1 (2%) 1 (2%)
Inflammation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 1 (2%) 1 (2%) 3 (5%)
Inflammation, Chronic Active 2 (3%) 2 (3%) 1 (2%)
Mineralization 3 (5%) 2 (3%)
Necrosis 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (3%)
Epithelium, Pigmentation 9 (15%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (51) (60)
Cardiomyopathy 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Inflammation, Chronic Active 7 (12%) 4 (8%) 3 (6%) 1 (2%)
Mineralization 1 (2%)
Endothelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (51) (51) (59)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Pigmentation 1 (2%)
Adrenal Gland, Medulla (60) (45) (40) (55)
Hyperplasia 3 (7%)
Islets, Pancreatic (60) (50) (49) (57)
Autolysis 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (39) (39) (32) (30)
Inflammation, Chronic 1 (3%) 1 (3%)
Pituitary Gland (56) (49) (50) (59)
Pars Distalis, Angiectasis 3 (5%) 4 (8%) 3 (5%)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 10 (18%) 11 (22%) 7 (14%) 2 (3%)
Thyroid Gland (60) (50) (50) (59)
Cyst 2 (4%)
Cyst Multilocular 1 (2%)
Inflammation, Chronic Active 4 (7%) 3 (6%) 2 (4%) 9 (15%)
Polyarteritis 1 (2%)
Ultimobranchial Cyst 1 (2%) 2 (3%)
C-Cell, Hyperplasia 1 (2%) 1 (2%) 2 (3%)
Follicular Cell, Hyperplasia 5 (8%) 8 (16%) 7 (14%) 16 (27%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1) (7) (9) (7)
Cyst 1 (14%) 1 (11%)
Cyst, Multiple 4 (57%) 2 (29%)
Inflammation, Acute 1 (14%)
Inflammation, Chronic 1 (14%) 1 (11%)
Inflammation, Chronic Active 2 (29%)
Pigmentation 1 (100%) 3 (43%) 7 (78%) 4 (57%)
Duct, Dilatation 1 (14%) 2 (22%) 4 (57%)
Ovary (60) (51) (50) (58)
Abscess 1 (2%)
Angiectasis 1 (2%)
Cyst 25 (42%) 20 (39%) 18 (36%) 22 (38%)
Cyst, Multiple 1 (2%)
Hemorrhage 12 (20%) 2 (4%) 4 (8%) 3 (5%)
Periovarian Tissue, Cyst 1 (2%)
Periovarian Tissue, Inflammation, Chronic 1 (2%)
Periovarian Tissue, Necrosis 1 (2%)
Uterus (60) (54) (53) (60)
Angiectasis 3 (5%) 2 (4%) 1 (2%)
Hydrometra 12 (20%) 13 (24%) 14 (26%) 24 (40%)
Infarct 1 (2%)
Metaplasia, Osseous 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Cervix, Inflammation, Acute 1 (2%)
Endometrium, Hyperplasia 55 (92%) 46 (85%) 40 (75%) 50 (83%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (50) (50) (60)
Myeloid Cell, Sternal, Hyperplasia 1 (2%)
Sternal, Myelofibrosis 36 (60%) 32 (64%) 36 (72%) 37 (62%)
Lymph Node (57) (47) (48) (60)
Mandibular, Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (3%)
Mandibular, Inflammation, Chronic Active 2 (4%)
Mandibular, Pigmentation 1 (2%)
Mediastinal, Fibrosis 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 2 (4%)
Mediastinal, Inflammation, Chronic Active 1 (2%)
Pancreatic, Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Inflammation, Chronic Active 1 (2%)
Renal, Angiectasis 1 (2%)
Lymph Node, Mesenteric (58) (46) (47) (59)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Autolysis 1 (2%)
Depletion Lymphoid 1 (2%) 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 2 (3%) 3 (7%) 2 (4%)
Infiltration Cellular, Histiocyte 8 (14%) 5 (8%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 8 (14%) 5 (8%)
Thrombosis 1 (2%)
Spleen (59) (51) (50) (60)
Depletion Lymphoid 1 (2%) 2 (4%) 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 7 (12%) 3 (6%) 2 (4%) 2 (3%)
Hyperplasia, Lymphoid 3 (5%) 4 (8%) 1 (2%) 5 (8%)
Inflammation, Granulomatous 1 (2%)
Endothelium, Hyperplasia 1 (2%)
Thymus (53) (43) (45) (56)
Autolysis 1 (2%)
Depletion Lymphoid 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (54) (48) (49) (57)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Skin (60) (52) (55) (59)
Cyst Epithelial Inclusion 1 (2%)
Epidermis, Inflammation, Acute 1 (2%)
Sebaceous Gland, Hyperplasia 1 (2%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (50) (51) (59)
Joint, Tarsal, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (51) (60)
Autolysis 1 (2%)
Thalamus, Mineralization 50 (83%) 25 (50%) 29 (57%) 50 (83%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (50) (52) (60)
Infiltration Cellular, Histiocyte 1 (2%) 3 (6%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%)
Nose (60) (50) (50) (60)
Inflammation, Acute 9 (15%) 15 (30%) 16 (32%) 11 (18%)
Glands, Inflammation, Acute 5 (8%) 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%)
Vomeronasal Organ, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2) (1) (1)
Cornea, Inflammation, Chronic Active 1 (50%)
Lens, Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (50) (51) (60)
Autolysis 1 (2%)
Glomerulosclerosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 56 (93%) 40 (80%) 45 (88%) 57 (95%)
Metaplasia, Osseous 2 (4%) 1 (2%)
Papilla, Necrosis 1 (2%)
Renal Tubule, Atrophy 1 (2%)
Renal Tubule, Degeneration, Hyaline 3 (6%)
Renal Tubule, Regeneration 2 (3%) 3 (6%) 4 (8%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (60) (50) (50) (60)
Angiectasis 1 (2%)
Autolysis 3 (5%) 1 (2%) 2 (4%) 1 (2%)
Inflammation, Chronic 7 (12%) 7 (12%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Polyarteritis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 5 6 8 6
Dead 2 1 5 2
Survivors
Terminal Sacrifice 43 42 37 42
Dead 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (53) (47) (48) (55)
Autolysis 1 (2%) 2 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Intestine Large, Cecum (60) (60) (60) (60)
Autolysis 1 (2%) 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Epithelium, Pigmentation 8 (13%)
Submucosa, Epithelium, Proliferation 1 (2%)
Intestine Large, Colon (60) (60) (59) (60)
Autolysis 1 (2%) 1 (2%) 1 (2%)
Epithelium, Pigmentation 5 (8%)
Intestine Large, Rectum (60) (60) (59) (60)
Autolysis 1 (2%) 1 (2%)
Intestine Small, Duodenum (60) (59) (60) (60)
Autolysis 1 (2%) 1 (2%) 2 (3%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Intestine Small, Ileum (60) (60) (60) (60)
Autolysis 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (5%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (3%)
Epithelium, Pigmentation 7 (12%)
Intestine Small, Jejunum (60) (60) (60) (60)
Autolysis 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Epithelium, Pigmentation 5 (8%)
Liver (60) (59) (60) (60)
Angiectasis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Autolysis 1 (2%) 2 (3%)
Basophilic Focus 1 (2%) 2 (3%) 1 (2%)
Clear Cell Focus 10 (17%) 5 (8%) 5 (8%) 2 (3%)
Cyst Multilocular 1 (2%)
Eosinophilic Focus 6 (10%) 8 (14%) 5 (8%) 7 (12%)
Fatty Change 33 (55%) 23 (39%) 32 (53%) 34 (57%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Inflammation, Acute 2 (3%)
Inflammation, Chronic Active 2 (3%) 5 (8%) 3 (5%)
Mixed Cell Focus 1 (2%) 2 (3%) 1 (2%) 6 (10%)
Necrosis 3 (5%) 6 (10%) 3 (5%) 2 (3%)
Necrosis, Coagulative 2 (3%) 2 (3%) 1 (2%)
Mesentery (5) (10) (4) (8)
Angiectasis 1 (10%)
Fibrosis 2 (40%) 1 (10%) 3 (75%) 8 (100%)
Hemorrhage 3 (60%) 8 (80%) 2 (50%) 1 (13%)
Inflammation, Chronic 2 (40%) 1 (13%)
Inflammation, Chronic Active 1 (10%) 3 (75%) 4 (50%)
Necrosis 1 (20%) 1 (10%) 3 (38%)
Necrosis, Coagulative 1 (13%)
Pancreas (60) (50) (50) (59)
Autolysis 1 (2%)
Cytoplasmic Alteration 1 (2%) 1 (2%) 1 (2%) 3 (5%)
Inflammation, Chronic 2 (3%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Acinus, Atrophy 2 (4%)
Duct, Concretion 1 (2%)
Duct, Dilatation 1 (2%)
Salivary Glands (60) (49) (50) (60)
Parotid Gland, Inflammation, Chronic 1 (2%) 4 (8%)
Sublingual Gland, Inflammation, Chronic 2 (3%) 1 (2%)
Submandibular Gland, Inflammation 1 (2%)
Submandibular Gland, Inflammation, Chronic 43 (72%) 34 (69%) 32 (64%) 42 (70%)
Stomach, Forestomach (60) (59) (60) (60)
Acanthosis 1 (2%) 2 (3%) 2 (3%)
Autolysis 1 (2%)
Hyperkeratosis 1 (2%) 2 (3%) 2 (3%)
Hyperplasia 2 (3%)
Hyperplasia, Basal Cell 2 (3%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 4 (7%) 2 (3%)
Mineralization 2 (3%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Stomach, Glandular (60) (60) (60) (60)
Autolysis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Erosion 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 4 (7%) 1 (2%)
Mineralization 1 (2%) 1 (2%) 2 (3%)
Epithelium, Pigmentation 6 (10%)
Mucosa, Mineralization 1 (2%)
Tongue (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (51) (60)
Inflammation, Chronic Active 3 (5%) 3 (6%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (50) (50) (59)
Hyperplasia 6 (10%) 5 (10%) 5 (10%) 5 (8%)
Adrenal Gland, Medulla (60) (42) (43) (59)
Hyperplasia 2 (5%)
Islets, Pancreatic (60) (50) (50) (59)
Hyperplasia 2 (3%) 2 (4%)
Parathyroid Gland (43) (27) (36) (40)
Cyst 1 (2%)
Pituitary Gland (60) (49) (50) (60)
Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (2%) 2 (3%)
Thyroid Gland (60) (49) (49) (60)
Autolysis 1 (2%)
Cyst 1 (2%)
Cyst Multilocular 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Follicle, Cyst 1 (2%)
Follicle, Cyst, Multiple 1 (2%)
Follicular Cell, Hyperplasia 2 (3%) 1 (2%) 1 (2%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (50) (50) (60)
Granuloma Sperm 1 (2%)
Inflammation, Chronic 3 (5%) 6 (10%)
Inflammation, Chronic Active 2 (3%) 1 (2%) 1 (2%) 2 (3%)
Preputial Gland (25) (24) (29) (31)
Cyst 1 (4%)
Cyst, Multiple 3 (12%) 4 (17%) 6 (21%) 7 (23%)
Inflammation, Chronic 2 (8%) 5 (17%) 2 (6%)
Inflammation, Chronic Active 13 (52%) 13 (54%) 8 (28%) 15 (48%)
Pigmentation 1 (4%)
Duct, Dilatation 19 (76%) 18 (75%) 21 (72%) 19 (61%)
Prostate (60) (50) (50) (60)
Inflammation, Chronic 6 (10%) 4 (7%)
Inflammation, Chronic Active 3 (5%) 1 (2%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Seminal Vesicle (50) (51) (50) (49)
Fibrosis 2 (4%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Testes (60) (50) (50) (60)
Inflammation, Chronic Active 1 (2%)
Seminiferous Tubule, Atrophy 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (50) (49) (60)
Autolysis 1 (2%)
Myeloid Cell, Sternal, Hyperplasia 1 (2%)
Sternal, Myelofibrosis 1 (2%)
Lymph Node (57) (51) (46) (57)
Lumbar, Hyperplasia, Lymphoid 1 (2%)
Mandibular, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mandibular, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Angiectasis 2 (4%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (56) (50) (46) (56)
Angiectasis 6 (11%) 3 (6%) 4 (7%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%) 3 (7%)
Hyperplasia, Plasma Cell 2 (4%)
Infiltration Cellular, Histiocyte 7 (13%) 1 (2%) 6 (11%)
Inflammation, Granulomatous 1 (2%)
Pigmentation 7 (13%) 1 (2%) 5 (9%)
Polyarteritis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Sinus, Ectasia 1 (2%)
Spleen (60) (50) (52) (59)
Angiectasis 1 (2%) 1 (2%)
Autolysis 1 (2%)
Depletion Lymphoid 3 (5%) 4 (8%) 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 6 (12%) 3 (5%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Thymus (48) (47) (42) (46)
Cyst 2 (4%) 3 (7%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (58) (47) (51) (60)
Autolysis 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Parakeratosis 1 (2%)
Ulcer 1 (2%)
Epidermis, Inflammation, Acute 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (2%)
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (49) (60)
Infarct 1 (2%)
Inflammation, Chronic Active 1 (2%)
Thalamus, Mineralization 48 (80%) 30 (60%) 31 (63%) 55 (92%)
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RESPIRATORY SYSTEM
Lung (60) (50) (50) (60)
Infiltration Cellular, Histiocyte 2 (3%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Leukocytosis 1 (2%)
Metaplasia, Osseous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:03
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 4 (7%) 2 (4%) 3 (5%)
Nose (58) (49) (50) (60)
Inflammation, Acute 4 (7%) 7 (14%) 5 (10%) 4 (7%)
Glands, Inflammation, Acute 1 (2%)
Trachea (59) (49) (48) (60)
Autolysis 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (4) (1) (6)
Cornea, Inflammation, Chronic Active 1 (25%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (53) (50) (60)
Autolysis 1 (2%)
Cyst 1 (2%) 1 (2%)
Glomerulosclerosis 1 (2%) 1 (2%)
Inflammation, Chronic 56 (93%) 47 (89%) 48 (96%) 45 (75%)
Metaplasia, Osseous 1 (2%)
Medulla, Foreign Body 1 (2%)
Renal Tubule, Atrophy 3 (6%)
Renal Tubule, Degeneration, Hyaline 1 (2%)
Renal Tubule, Mineralization 6 (10%) 3 (5%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Regeneration 1 (2%) 4 (8%) 2 (4%)
Urinary Bladder (60) (50) (50) (60)
Autolysis 1 (2%) 1 (2%)
Calculus Gross Observation 2 (3%) 1 (2%) 3 (5%)
Calculus Micro Observation Only 1 (2%) 3 (5%)
Fibrosis 1 (2%)
Inflammation, Chronic 3 (5%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Ulcer 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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