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https://ntp.niehs.nih.gov/go/3513

TDMS Study 05084-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         TURMERIC OLEORESIN


NTP Experiment-Test: 05084-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 00:23:03




       Facility:  TSI Mason Research

       Chemical CAS #:  458-37-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10            9           10                                     
  Early Deaths                                                                                                                      
    Dead                                               3            2            7            1                                     
    Moribund                                           7            7           10            7                                     
    Accident                                           1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           40           34           41                                     
    Dead                                               1                                      1                                     
    Moribund                                           1            1                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (55)         (48)         (46)         (57)                                   
      Autolysis                                        2 (4%)       1 (2%)       3 (7%)       1 (2%)                                
      Inflammation, Chronic                            1 (2%)       1 (2%)                    3 (5%)                                
   Intestine Large, Cecum                             (59)         (60)         (59)         (60)                                   
      Autolysis                                        4 (7%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Epithelium, Pigmentation                                                               10 (17%)                               
   Intestine Large, Colon                             (60)         (60)         (58)         (60)                                   
      Autolysis                                        3 (5%)       1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Epithelium, Pigmentation                                                                6 (10%)                               
   Intestine Large, Rectum                            (60)         (60)         (58)         (60)                                   
      Autolysis                                        3 (5%)       1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Intestine Small, Duodenum                          (60)         (60)         (57)         (60)                                   
      Autolysis                                        3 (5%)       1 (2%)       2 (4%)       1 (2%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
   Intestine Small, Ileum                             (60)         (60)         (58)         (59)                                   
      Autolysis                                        3 (5%)       1 (2%)       2 (3%)       1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)       3 (5%)       1 (2%)       3 (5%)                                
      Epithelium, Hyperplasia                                                    1 (2%)                                             
      Epithelium, Pigmentation                                                                9 (15%)                               
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
   Intestine Small, Jejunum                           (60)         (60)         (57)         (60)                                   
      Autolysis                                        4 (7%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            2 (3%)                                                                       
      Epithelium, Pigmentation                                                                2 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Liver                                              (60)         (52)         (56)         (60)                                   
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Autolysis                                        1 (2%)                                                                       
      Basophilic Focus                                                           2 (4%)                                             
      Clear Cell Focus                                 5 (8%)       2 (4%)       3 (5%)       2 (3%)                                
      Eosinophilic Focus                               2 (3%)       2 (4%)       8 (14%)      8 (13%)                               
      Fatty Change                                     1 (2%)       2 (4%)       2 (4%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Infarct                                                                    1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                                         2 (4%)                    3 (5%)                                
      Inflammation, Chronic Active                    26 (43%)     29 (56%)     27 (48%)     37 (62%)                               
      Mixed Cell Focus                                 3 (5%)       1 (2%)       2 (4%)       1 (2%)                                
      Necrosis                                         2 (3%)      12 (23%)      3 (5%)                                             
      Necrosis, Coagulative                            2 (3%)                    2 (4%)       2 (3%)                                
      Oval Cell, Hyperplasia                           1 (2%)                                                                       
   Mesentery                                          (7)          (8)          (5)          (4)                                    
      Fibrosis                                         6 (86%)      8 (100%)     5 (100%)     3 (75%)                               
      Hemorrhage                                                                 1 (20%)      1 (25%)                               
      Inflammation, Chronic                                         5 (63%)      2 (40%)                                            
      Inflammation, Chronic Active                                               2 (40%)      3 (75%)                               
      Necrosis                                         5 (71%)      6 (75%)      3 (60%)      3 (75%)                               
      Necrosis, Coagulative                                         1 (13%)      2 (40%)                                            
   Pancreas                                           (60)         (50)         (49)         (60)                                   
      Autolysis                                        1 (2%)                                                                       
      Cyst                                                          2 (4%)       1 (2%)                                             
      Cytoplasmic Alteration                                        3 (6%)       2 (4%)                                             
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                            5 (8%)                                 4 (7%)                                
      Inflammation, Chronic Active                     2 (3%)       1 (2%)       1 (2%)                                             
      Acinus, Atrophy                                  2 (3%)                    1 (2%)                                             
   Salivary Glands                                    (60)         (50)         (51)         (60)                                   
      Parotid Gland, Atrophy                                                                  1 (2%)                                
      Parotid Gland, Inflammation, Chronic             3 (5%)                                 3 (5%)                                
      Sublingual Gland, Inflammation, Chronic          7 (12%)                   2 (4%)       4 (7%)                                
      Submandibular Gland, Atrophy                                  2 (4%)                                                          
      Submandibular Gland, Inflammation, Chronic      51 (85%)     34 (68%)     31 (61%)     50 (83%)                               
   Stomach, Forestomach                               (59)         (60)         (59)         (59)                                   
      Acanthosis                                       1 (2%)                    2 (3%)       4 (7%)                                
      Hyperkeratosis                                   1 (2%)       1 (2%)       2 (3%)       4 (7%)                                
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
      Inflammation, Chronic Active                     2 (3%)                                 3 (5%)                                
      Ulcer, Acute                                                                            1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (59)         (59)                                   
      Autolysis                                        1 (2%)       1 (2%)                                                          
      Inflammation                                                               1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                            1 (2%)       1 (2%)       3 (5%)                                             
      Inflammation, Chronic Active                     2 (3%)       2 (3%)                    1 (2%)                                
      Mineralization                                                3 (5%)                    2 (3%)                                
      Necrosis                                         1 (2%)                    1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)                    1 (2%)       2 (3%)                                
      Epithelium, Pigmentation                                                                9 (15%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (51)         (60)                                   
      Cardiomyopathy                                                             1 (2%)       1 (2%)                                
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic Active                     7 (12%)      4 (8%)       3 (6%)       1 (2%)                                
      Mineralization                                                1 (2%)                                                          
      Endothelium, Hyperplasia                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (51)         (51)         (59)                                   
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
   Adrenal Gland, Medulla                             (60)         (45)         (40)         (55)                                   
      Hyperplasia                                                   3 (7%)                                                          
   Islets, Pancreatic                                 (60)         (50)         (49)         (57)                                   
      Autolysis                                        1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (39)         (39)         (32)         (30)                                   
      Inflammation, Chronic                                         1 (3%)                    1 (3%)                                
   Pituitary Gland                                    (56)         (49)         (50)         (59)                                   
      Pars Distalis, Angiectasis                       3 (5%)       4 (8%)                    3 (5%)                                
      Pars Distalis, Cyst                                           1 (2%)                    1 (2%)                                
      Pars Distalis, Hyperplasia                      10 (18%)     11 (22%)      7 (14%)      2 (3%)                                
   Thyroid Gland                                      (60)         (50)         (50)         (59)                                   
      Cyst                                                          2 (4%)                                                          
      Cyst Multilocular                                                          1 (2%)                                             
      Inflammation, Chronic Active                     4 (7%)       3 (6%)       2 (4%)       9 (15%)                               
      Polyarteritis                                                              1 (2%)                                             
      Ultimobranchial Cyst                                                       1 (2%)       2 (3%)                                
      C-Cell, Hyperplasia                              1 (2%)       1 (2%)                    2 (3%)                                
      Follicular Cell, Hyperplasia                     5 (8%)       8 (16%)      7 (14%)     16 (27%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)                       (1)                                    
      Hemorrhage                                                                              1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (1)          (7)          (9)          (7)                                    
      Cyst                                                          1 (14%)      1 (11%)                                            
      Cyst, Multiple                                                4 (57%)                   2 (29%)                               
      Inflammation, Acute                                           1 (14%)                                                         
      Inflammation, Chronic                                         1 (14%)      1 (11%)                                            
      Inflammation, Chronic Active                                  2 (29%)                                                         
      Pigmentation                                     1 (100%)     3 (43%)      7 (78%)      4 (57%)                               
      Duct, Dilatation                                              1 (14%)      2 (22%)      4 (57%)                               
   Ovary                                              (60)         (51)         (50)         (58)                                   
      Abscess                                          1 (2%)                                                                       
      Angiectasis                                                                1 (2%)                                             
      Cyst                                            25 (42%)     20 (39%)     18 (36%)     22 (38%)                               
      Cyst, Multiple                                   1 (2%)                                                                       
      Hemorrhage                                      12 (20%)      2 (4%)       4 (8%)       3 (5%)                                
      Periovarian Tissue, Cyst                                      1 (2%)                                                          
      Periovarian Tissue, Inflammation, Chronic                     1 (2%)                                                          
      Periovarian Tissue, Necrosis                     1 (2%)                                                                       
   Uterus                                             (60)         (54)         (53)         (60)                                   
      Angiectasis                                      3 (5%)                    2 (4%)       1 (2%)                                
      Hydrometra                                      12 (20%)     13 (24%)     14 (26%)     24 (40%)                               
      Infarct                                                       1 (2%)                                                          
      Metaplasia, Osseous                                           1 (2%)                                                          
      Thrombosis                                       1 (2%)                                 1 (2%)                                
      Cervix, Inflammation, Acute                      1 (2%)                                                                       
      Endometrium, Hyperplasia                        55 (92%)     46 (85%)     40 (75%)     50 (83%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (50)         (50)         (60)                                   
      Myeloid Cell, Sternal, Hyperplasia                            1 (2%)                                                          
      Sternal, Myelofibrosis                          36 (60%)     32 (64%)     36 (72%)     37 (62%)                               
   Lymph Node                                         (57)         (47)         (48)         (60)                                   
      Mandibular, Hyperplasia, Lymphoid                1 (2%)       1 (2%)                    2 (3%)                                
      Mandibular, Inflammation, Chronic Active         2 (4%)                                                                       
      Mandibular, Pigmentation                                      1 (2%)                                                          
      Mediastinal, Fibrosis                            1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid               2 (4%)                                                                       
      Mediastinal, Inflammation, Chronic Active        1 (2%)                                                                       
      Pancreatic, Fibrosis                             1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pancreatic, Hyperplasia, Lymphoid                                          1 (2%)                                             
      Pancreatic, Inflammation, Chronic Active         1 (2%)                                                                       
      Renal, Angiectasis                               1 (2%)                                                                       
   Lymph Node, Mesenteric                             (58)         (46)         (47)         (59)                                   
      Angiectasis                                      1 (2%)                    1 (2%)       1 (2%)                                
      Autolysis                                        1 (2%)                                                                       
      Depletion Lymphoid                               1 (2%)                    1 (2%)       1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia, Lymphoid                            2 (3%)       3 (7%)       2 (4%)                                             
      Infiltration Cellular, Histiocyte                8 (14%)                                5 (8%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Pigmentation                                     8 (14%)                                5 (8%)                                
      Thrombosis                                                                 1 (2%)                                             
   Spleen                                             (59)         (51)         (50)         (60)                                   
      Depletion Lymphoid                               1 (2%)       2 (4%)       1 (2%)                                             
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                 7 (12%)      3 (6%)       2 (4%)       2 (3%)                                
      Hyperplasia, Lymphoid                            3 (5%)       4 (8%)       1 (2%)       5 (8%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
      Endothelium, Hyperplasia                                                                1 (2%)                                
   Thymus                                             (53)         (43)         (45)         (56)                                   
      Autolysis                                        1 (2%)                                                                       
      Depletion Lymphoid                               1 (2%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (48)         (49)         (57)                                   
      Hyperplasia                                      2 (4%)                    1 (2%)       1 (2%)                                
   Skin                                               (60)         (52)         (55)         (59)                                   
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Epidermis, Inflammation, Acute                                             1 (2%)                                             
      Sebaceous Gland, Hyperplasia                                                            1 (2%)                                
      Subcutaneous Tissue, Inflammation, Acute                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (50)         (51)         (59)                                   
      Joint, Tarsal, Hyperostosis                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (51)         (60)                                   
      Autolysis                                        1 (2%)                                                                       
      Thalamus, Mineralization                        50 (83%)     25 (50%)     29 (57%)     50 (83%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (50)         (52)         (60)                                   
      Infiltration Cellular, Histiocyte                1 (2%)                    3 (6%)                                             
      Inflammation, Chronic Active                                  2 (4%)       1 (2%)       1 (2%)                                
      Metaplasia, Osseous                                                        1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                                                        1 (2%)                                
   Nose                                               (60)         (50)         (50)         (60)                                   
      Inflammation, Acute                              9 (15%)     15 (30%)     16 (32%)     11 (18%)                               
      Glands, Inflammation, Acute                      5 (8%)                                 1 (2%)                                
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                                                                       
      Vomeronasal Organ, Inflammation, Acute                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)          (1)          (1)                                    
      Cornea, Inflammation, Chronic Active                          1 (50%)                                                         
      Lens, Cataract                                                             1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (50)         (51)         (60)                                   
      Autolysis                                        1 (2%)                                                                       
      Glomerulosclerosis                                            1 (2%)                                                          
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic                           56 (93%)     40 (80%)     45 (88%)     57 (95%)                               
      Metaplasia, Osseous                                           2 (4%)                    1 (2%)                                
      Papilla, Necrosis                                                          1 (2%)                                             
      Renal Tubule, Atrophy                                                      1 (2%)                                             
      Renal Tubule, Degeneration, Hyaline                           3 (6%)                                                          
      Renal Tubule, Regeneration                       2 (3%)       3 (6%)       4 (8%)       1 (2%)                                
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
   Urinary Bladder                                    (60)         (50)         (50)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Autolysis                                        3 (5%)       1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic                            7 (12%)                                7 (12%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Polyarteritis                                    1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                           5            6            8            6                                     
    Dead                                               2            1            5            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           42           37           42                                     
    Dead                                                            1                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (53)         (47)         (48)         (55)                                   
      Autolysis                                                     1 (2%)                    2 (4%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                 1 (2%)                                
   Intestine Large, Cecum                             (60)         (60)         (60)         (60)                                   
      Autolysis                                        1 (2%)       2 (3%)                    1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Ulcer                                                                      1 (2%)                                             
      Epithelium, Hyperplasia                                                                 1 (2%)                                
      Epithelium, Pigmentation                                                                8 (13%)                               
      Submucosa, Epithelium, Proliferation                                                    1 (2%)                                
   Intestine Large, Colon                             (60)         (60)         (59)         (60)                                   
      Autolysis                                        1 (2%)       1 (2%)                    1 (2%)                                
      Epithelium, Pigmentation                                                                5 (8%)                                
   Intestine Large, Rectum                            (60)         (60)         (59)         (60)                                   
      Autolysis                                        1 (2%)                                 1 (2%)                                
   Intestine Small, Duodenum                          (60)         (59)         (60)         (60)                                   
      Autolysis                                        1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (2%)                                
   Intestine Small, Ileum                             (60)         (60)         (60)         (60)                                   
      Autolysis                                        1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)       3 (5%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                  2 (3%)                                                          
      Epithelium, Pigmentation                                                                7 (12%)                               
   Intestine Small, Jejunum                           (60)         (60)         (60)         (60)                                   
      Autolysis                                        1 (2%)       1 (2%)                    1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                    1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
      Epithelium, Pigmentation                                                                5 (8%)                                
   Liver                                              (60)         (59)         (60)         (60)                                   
      Angiectasis                                                   1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Autolysis                                                     1 (2%)                    2 (3%)                                
      Basophilic Focus                                 1 (2%)       2 (3%)                    1 (2%)                                
      Clear Cell Focus                                10 (17%)      5 (8%)       5 (8%)       2 (3%)                                
      Cyst Multilocular                                1 (2%)                                                                       
      Eosinophilic Focus                               6 (10%)      8 (14%)      5 (8%)       7 (12%)                               
      Fatty Change                                    33 (55%)     23 (39%)     32 (53%)     34 (57%)                               
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)                                             
      Inflammation, Acute                              2 (3%)                                                                       
      Inflammation, Chronic Active                     2 (3%)       5 (8%)       3 (5%)                                             
      Mixed Cell Focus                                 1 (2%)       2 (3%)       1 (2%)       6 (10%)                               
      Necrosis                                         3 (5%)       6 (10%)      3 (5%)       2 (3%)                                
      Necrosis, Coagulative                            2 (3%)       2 (3%)       1 (2%)                                             
   Mesentery                                          (5)          (10)         (4)          (8)                                    
      Angiectasis                                                   1 (10%)                                                         
      Fibrosis                                         2 (40%)      1 (10%)      3 (75%)      8 (100%)                              
      Hemorrhage                                       3 (60%)      8 (80%)      2 (50%)      1 (13%)                               
      Inflammation, Chronic                            2 (40%)                                1 (13%)                               
      Inflammation, Chronic Active                                  1 (10%)      3 (75%)      4 (50%)                               
      Necrosis                                         1 (20%)      1 (10%)                   3 (38%)                               
      Necrosis, Coagulative                                                                   1 (13%)                               
   Pancreas                                           (60)         (50)         (50)         (59)                                   
      Autolysis                                                                  1 (2%)                                             
      Cytoplasmic Alteration                           1 (2%)       1 (2%)       1 (2%)       3 (5%)                                
      Inflammation, Chronic                                                                   2 (3%)                                
      Inflammation, Chronic Active                                  2 (4%)       1 (2%)                                             
      Acinus, Atrophy                                                            2 (4%)                                             
      Duct, Concretion                                                                        1 (2%)                                
      Duct, Dilatation                                                                        1 (2%)                                
   Salivary Glands                                    (60)         (49)         (50)         (60)                                   
      Parotid Gland, Inflammation, Chronic                          1 (2%)       4 (8%)                                             
      Sublingual Gland, Inflammation, Chronic          2 (3%)                    1 (2%)                                             
      Submandibular Gland, Inflammation                1 (2%)                                                                       
      Submandibular Gland, Inflammation, Chronic      43 (72%)     34 (69%)     32 (64%)     42 (70%)                               
   Stomach, Forestomach                               (60)         (59)         (60)         (60)                                   
      Acanthosis                                                    1 (2%)       2 (3%)       2 (3%)                                
      Autolysis                                                                               1 (2%)                                
      Hyperkeratosis                                                1 (2%)       2 (3%)       2 (3%)                                
      Hyperplasia                                      2 (3%)                                                                       
      Hyperplasia, Basal Cell                                                    2 (3%)       1 (2%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                                               4 (7%)       2 (3%)                                
      Mineralization                                                2 (3%)                                                          
      Ulcer                                                                      1 (2%)                                             
      Epithelium, Hyperplasia                                       1 (2%)                    1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
      Autolysis                                                                               1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Erosion                                                       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                                  4 (7%)       1 (2%)                                             
      Mineralization                                   1 (2%)       1 (2%)       2 (3%)                                             
      Epithelium, Pigmentation                                                                6 (10%)                               
      Mucosa, Mineralization                                        1 (2%)                                                          
   Tongue                                             (1)          (1)                                                              
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (51)         (60)                                   
      Inflammation, Chronic Active                     3 (5%)       3 (6%)                                                          
      Mineralization                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (50)         (50)         (59)                                   
      Hyperplasia                                      6 (10%)      5 (10%)      5 (10%)      5 (8%)                                
   Adrenal Gland, Medulla                             (60)         (42)         (43)         (59)                                   
      Hyperplasia                                                   2 (5%)                                                          
   Islets, Pancreatic                                 (60)         (50)         (50)         (59)                                   
      Hyperplasia                                      2 (3%)       2 (4%)                                                          
   Parathyroid Gland                                  (43)         (27)         (36)         (40)                                   
      Cyst                                             1 (2%)                                                                       
   Pituitary Gland                                    (60)         (49)         (50)         (60)                                   
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
   Thyroid Gland                                      (60)         (49)         (49)         (60)                                   
      Autolysis                                                                               1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Cyst Multilocular                                                          1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicle, Cyst, Multiple                         1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (50)         (50)         (60)                                   
      Granuloma Sperm                                                                         1 (2%)                                
      Inflammation, Chronic                            3 (5%)                                 6 (10%)                               
      Inflammation, Chronic Active                     2 (3%)       1 (2%)       1 (2%)       2 (3%)                                
   Preputial Gland                                    (25)         (24)         (29)         (31)                                   
      Cyst                                             1 (4%)                                                                       
      Cyst, Multiple                                   3 (12%)      4 (17%)      6 (21%)      7 (23%)                               
      Inflammation, Chronic                            2 (8%)                    5 (17%)      2 (6%)                                
      Inflammation, Chronic Active                    13 (52%)     13 (54%)      8 (28%)     15 (48%)                               
      Pigmentation                                                  1 (4%)                                                          
      Duct, Dilatation                                19 (76%)     18 (75%)     21 (72%)     19 (61%)                               
   Prostate                                           (60)         (50)         (50)         (60)                                   
      Inflammation, Chronic                            6 (10%)                                4 (7%)                                
      Inflammation, Chronic Active                     3 (5%)       1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Seminal Vesicle                                    (50)         (51)         (50)         (49)                                   
      Fibrosis                                         2 (4%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
   Testes                                             (60)         (50)         (50)         (60)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Seminiferous Tubule, Atrophy                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (50)         (49)         (60)                                   
      Autolysis                                                                               1 (2%)                                
      Myeloid Cell, Sternal, Hyperplasia                                         1 (2%)                                             
      Sternal, Myelofibrosis                                                                  1 (2%)                                
   Lymph Node                                         (57)         (51)         (46)         (57)                                   
      Lumbar, Hyperplasia, Lymphoid                                 1 (2%)                                                          
      Mandibular, Hyperplasia, Lymphoid                             1 (2%)       1 (2%)                                             
      Mandibular, Hyperplasia, Plasma Cell                          1 (2%)                                                          
      Mediastinal, Angiectasis                         2 (4%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                                                      1 (2%)                                
      Pancreatic, Hyperplasia, Lymphoid                1 (2%)                                                                       
      Pancreatic, Hyperplasia, Plasma Cell             1 (2%)                                                                       
   Lymph Node, Mesenteric                             (56)         (50)         (46)         (56)                                   
      Angiectasis                                      6 (11%)      3 (6%)                    4 (7%)                                
      Hyperplasia, Lymphoid                            1 (2%)       3 (6%)       3 (7%)                                             
      Hyperplasia, Plasma Cell                                      2 (4%)                                                          
      Infiltration Cellular, Histiocyte                7 (13%)                   1 (2%)       6 (11%)                               
      Inflammation, Granulomatous                                                1 (2%)                                             
      Pigmentation                                     7 (13%)                   1 (2%)       5 (9%)                                
      Polyarteritis                                    1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Sinus, Ectasia                                                             1 (2%)                                             
   Spleen                                             (60)         (50)         (52)         (59)                                   
      Angiectasis                                                                1 (2%)       1 (2%)                                
      Autolysis                                                                               1 (2%)                                
      Depletion Lymphoid                               3 (5%)                    4 (8%)       1 (2%)                                
      Hematopoietic Cell Proliferation                              3 (6%)       6 (12%)      3 (5%)                                
      Hyperplasia, Lymphoid                                         2 (4%)       1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
   Thymus                                             (48)         (47)         (42)         (46)                                   
      Cyst                                             2 (4%)                    3 (7%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (58)         (47)         (51)         (60)                                   
      Autolysis                                                                               1 (2%)                                
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Parakeratosis                                                              1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
      Epidermis, Inflammation, Acute                                                          1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (49)         (60)                                   
      Infarct                                                                                 1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Thalamus, Mineralization                        48 (80%)     30 (60%)     31 (63%)     55 (92%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (50)         (50)         (60)                                   
      Infiltration Cellular, Histiocyte                2 (3%)       3 (6%)                    1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Leukocytosis                                                               1 (2%)                                             
      Metaplasia, Osseous                                                                     1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05084-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 00:23:03  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 4 (7%)       2 (4%)                    3 (5%)                                
   Nose                                               (58)         (49)         (50)         (60)                                   
      Inflammation, Acute                              4 (7%)       7 (14%)      5 (10%)      4 (7%)                                
      Glands, Inflammation, Acute                      1 (2%)                                                                       
   Trachea                                            (59)         (49)         (48)         (60)                                   
      Autolysis                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (4)          (1)          (6)                                    
      Cornea, Inflammation, Chronic Active                          1 (25%)      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (53)         (50)         (60)                                   
      Autolysis                                                                               1 (2%)                                
      Cyst                                                                       1 (2%)       1 (2%)                                
      Glomerulosclerosis                                                         1 (2%)       1 (2%)                                
      Inflammation, Chronic                           56 (93%)     47 (89%)     48 (96%)     45 (75%)                               
      Metaplasia, Osseous                              1 (2%)                                                                       
      Medulla, Foreign Body                                         1 (2%)                                                          
      Renal Tubule, Atrophy                                         3 (6%)                                                          
      Renal Tubule, Degeneration, Hyaline                           1 (2%)                                                          
      Renal Tubule, Mineralization                     6 (10%)                                3 (5%)                                
      Renal Tubule, Pigmentation                                                 1 (2%)                                             
      Renal Tubule, Regeneration                       1 (2%)       4 (8%)       2 (4%)                                             
   Urinary Bladder                                    (60)         (50)         (50)         (60)                                   
      Autolysis                                        1 (2%)                                 1 (2%)                                
      Calculus Gross Observation                       2 (3%)                    1 (2%)       3 (5%)                                
      Calculus Micro Observation Only                               1 (2%)                    3 (5%)                                
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Chronic                            3 (5%)                                 1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Ulcer                                            1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------