TDMS Study 05084-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TURMERIC OLEORESIN
NTP Experiment-Test: 05084-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
Facility: TSI Mason Research
Chemical CAS #: 458-37-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 9 10
Early Deaths
Dead 3 2 7 1
Moribund 7 7 10 7
Accident 1
Survivors
Terminal Sacrifice 37 40 34 41
Dead 1 1
Moribund 1 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (55) (48) (46) (57)
Histiocytic Sarcoma, Metastatic 1 (2%)
Intestine Large, Cecum (59) (60) (59) (60)
Leiomyoma 1 (2%)
Intestine Small, Duodenum (60) (60) (57) (60)
Adenocarcinoma 1 (2%)
Polyp Adenomatous 1 (2%)
Intestine Small, Ileum (60) (60) (58) (59)
Intestine Small, Jejunum (60) (60) (57) (60)
Liver (60) (52) (56) (60)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatocellular Carcinoma 7 (12%) 5 (10%) 8 (14%) 5 (8%)
Hepatocellular Carcinoma, Multiple 2 (4%) 2 (3%)
Hepatocellular Adenoma 7 (12%) 5 (10%) 11 (20%) 8 (13%)
Hepatocellular Adenoma, Multiple 3 (6%) 9 (16%) 6 (10%)
Histiocytic Sarcoma, Metastatic 2 (4%) 1 (2%)
Pancreas (60) (50) (49) (60)
Salivary Glands (60) (50) (51) (60)
Stomach, Forestomach (59) (60) (59) (59)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 3 (5%)
Stomach, Glandular (60) (60) (59) (59)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (51) (60)
Histiocytic Sarcoma, Metastatic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (51) (51) (59)
Adenoma 1 (2%)
Adrenal Gland, Medulla (60) (45) (40) (55)
Pheochromocytoma Malignant 1 (2%)
Islets, Pancreatic (60) (50) (49) (57)
Adenoma 1 (2%)
Parathyroid Gland (39) (39) (32) (30)
Pituitary Gland (56) (49) (50) (59)
Pars Distalis, Adenoma 2 (4%) 4 (8%) 5 (8%)
Thyroid Gland (60) (50) (50) (59)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (60) (51) (50) (58)
Cystadenoma 1 (2%) 2 (4%) 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Hemangioma 1 (2%)
Histiocytic Sarcoma, Metastatic 1 (2%)
Luteoma 1 (2%)
Uterus (60) (54) (53) (60)
Histiocytic Sarcoma 2 (4%) 2 (4%) 3 (5%)
Polyp Stromal 1 (2%) 1 (2%)
Sarcoma Stromal 1 (2%)
Cervix, Basosquamous Tumor Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (50) (50) (60)
Sternal, Histiocytic Sarcoma, Metastatic 2 (4%)
Lymph Node (57) (47) (48) (60)
Lumbar, Histiocytic Sarcoma, Metastatic 1 (2%)
Mediastinal, Histiocytic Sarcoma, Metastatic 1 (2%)
Page 3
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Renal, Histiocytic Sarcoma, Metastatic 1 (2%)
Lymph Node, Mesenteric (58) (46) (47) (59)
Histiocytic Sarcoma, Metastatic 1 (2%)
Spleen (59) (51) (50) (60)
Hemangiosarcoma 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Thymus (53) (43) (45) (56)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (54) (48) (49) (57)
Adenocarcinoma 1 (2%)
Hemangiosarcoma 1 (2%)
Skin (60) (52) (55) (59)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (50) (51) (59)
Chordoma 1 (2%)
Skeletal Muscle (1) (1) (2)
Sarcoma 1 (100%)
Back, Adenocarcinoma, Metastatic, Uncertain
Primary Site 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (51) (60)
Meninges, Sarcoma 1 (2%) 1 (2%)
Meninges, Schwannoma Malignant, Metastatic 1 (2%)
Peripheral Nerve (1)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (50) (52) (60)
Alveolar/Bronchiolar Adenoma 4 (7%) 3 (6%) 4 (8%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (3%) 1 (2%) 3 (6%) 2 (3%)
Histiocytic Sarcoma, Metastatic 2 (4%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Nose (60) (50) (50) (60)
Histiocytic Sarcoma, Metastatic 1 (2%)
Page 4
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Trachea (60) (50) (51) (59)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (2) (1)
Adenoma 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (50) (51) (60)
Histiocytic Sarcoma, Metastatic 1 (2%)
Urinary Bladder (60) (50) (50) (60)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 2 (3%) 2 (3%) 3 (5%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
Lymphoma Malignant Mixed 9 (15%) 13 (22%) 12 (20%) 7 (12%)
Lymphoma Malignant Undifferentiated Cell 2 (3%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 31 33 37 34
Total Primary Neoplasms 38 48 64 47
Total Animals with Benign Neoplasms 14 18 24 21
Total Benign Neoplasms 16 21 32 27
Total Animals with Malignant Neoplasms 21 25 23 17
Total Malignant Neoplasms 22 27 32 20
Total Animals with Metastatic Neoplasms 3 3 4 4
Total Metastatic Neoplasm 3 14 4 7
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 5 6 8 6
Dead 2 1 5 2
Survivors
Terminal Sacrifice 43 42 37 42
Dead 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (53) (47) (48) (55)
Intestine Large, Cecum (60) (60) (60) (60)
Intestine Small, Duodenum (60) (59) (60) (60)
Adenocarcinoma 1 (2%)
Intestine Small, Ileum (60) (60) (60) (60)
Adenocarcinoma 1 (2%)
Intestine Small, Jejunum (60) (60) (60) (60)
Adenocarcinoma 2 (3%) 2 (3%)
Liver (60) (59) (60) (60)
Hemangiosarcoma 1 (2%) 3 (5%) 1 (2%) 1 (2%)
Hepatoblastoma 3 (5%) 1 (2%)
Hepatocellular Carcinoma 12 (20%) 15 (25%) 14 (23%) 13 (22%)
Hepatocellular Carcinoma, Multiple 3 (5%) 4 (7%) 5 (8%)
Hepatocellular Adenoma 16 (27%) 12 (20%) 13 (22%) 12 (20%)
Hepatocellular Adenoma, Multiple 9 (15%) 17 (29%) 24 (40%) 19 (32%)
Pancreas (60) (50) (50) (59)
Stomach, Forestomach (60) (59) (60) (60)
Squamous Cell Papilloma 2 (3%)
Tongue (1) (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (51) (60)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (50) (50) (59)
Adenoma 1 (2%) 1 (2%)
Adrenal Gland, Medulla (60) (42) (43) (59)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (60) (50) (50) (59)
Adenoma 1 (2%) 1 (2%)
Pituitary Gland (60) (49) (50) (60)
Thyroid Gland (60) (49) (49) (60)
Adenocarcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (50) (50) (60)
Preputial Gland (25) (24) (29) (31)
Prostate (60) (50) (50) (60)
Seminal Vesicle (50) (51) (50) (49)
Testes (60) (50) (50) (60)
Sertoli Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (50) (49) (60)
Lymph Node (57) (51) (46) (57)
Lymph Node, Mesenteric (56) (50) (46) (56)
Spleen (60) (50) (52) (59)
Hemangiosarcoma 1 (2%) 1 (2%) 1 (2%)
Thymus (48) (47) (42) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (58) (47) (51) (60)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Hemangioma 2 (4%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (49) (60)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (50) (50) (60)
Adenocarcinoma, Metastatic, Harderian Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 7 (12%) 8 (16%) 6 (12%) 10 (17%)
Alveolar/Bronchiolar Adenoma, Multiple 4 (7%) 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 4 (7%) 6 (12%) 4 (7%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 2 (3%) 2 (4%) 5 (10%) 3 (5%)
Squamous Cell Carcinoma 1 (2%)
Mediastinum, Hemangioma 1 (2%)
Nose (58) (49) (50) (60)
Adenocarcinoma, Metastatic, Harderian Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (1) (1)
Fibrosarcoma 1 (50%)
Harderian Gland (4) (4) (1) (6)
Adenocarcinoma 1 (25%)
Adenoma 4 (100%) 3 (75%) 1 (100%) 5 (83%)
Bilateral, Adenoma 1 (17%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (53) (50) (60)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (60) (50) (50) (60)
Page 9
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Mixed 3 (5%) 2 (3%) 7 (12%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05084-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/11/94
Route: DOSED FEED Time: 00:23:05
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 40 43 51 45
Total Primary Neoplasms 67 82 81 86
Total Animals with Benign Neoplasms 34 33 42 37
Total Benign Neoplasms 46 44 49 52
Total Animals with Malignant Neoplasms 18 28 27 30
Total Malignant Neoplasms 21 38 32 34
Total Animals with Metastatic Neoplasms 2 4 5 3
Total Metastatic Neoplasm 2 5 5 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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