TDMS Study 05084-02 Pathology Tables
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
Facility: TSI Mason Research
Chemical CAS #: 8024-37-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 5| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 3| 2| 5| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 5| 2| 3| 3| 3| 5|
| 1| 3| 1| 2| 0| 1| 0| 1| 6| 1| 0| 1| 1| 1| 1| 1| 3| 1| 1| 0| 8| 1| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + M + + + + + + + + + + + + + + + + + M +|
Autolysis | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 |
Hyperplasia, Lymphoid | |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | |
Clear Cell Focus | 1 2 2 2|
Eosinophilic Focus | 1 |
Fatty Change | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 1 1 3 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | 1 |
Necrosis, Coagulative | |
Necrosis | |
Oval Cell, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 2 1 2 |
Necrosis | 2 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | 4 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 4 1 |
Acinus, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 5| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 3| 2| 5| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 5| 2| 3| 3| 3| 5|
| 1| 3| 1| 2| 0| 1| 0| 1| 6| 1| 0| 1| 1| 1| 1| 1| 3| 1| 1| 0| 8| 1| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Inflammation, Chronic | 1 1 |
Sublingual Gland, Inflammation, | |
Chronic | 1 1 1 1 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 |
Necrosis | 1 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M M M + M M + + + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 1 1 1 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 5| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 3| 2| 5| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 5| 2| 3| 3| 3| 5|
| 1| 3| 1| 2| 0| 1| 0| 1| 6| 1| 0| 1| 1| 1| 1| 1| 3| 1| 1| 0| 8| 1| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Pigmentation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | 2 2 3 3 1 2 1 2 2 |
Cyst, Multiple | |
Hemorrhage | 3 1 2 2 |
Periovarian Tissue, Necrosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 2 3 |
Thrombosis | |
Cervix, Inflammation, Acute | |
Endometrium, Hyperplasia | 2 3 2 3 2 2 2 1 2 2 2 1 3 2 2 3 4 2 3 3 3 2 3 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | 1 2 3 1 3 1 1 1 2 1 1 2 2 1 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + M + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | 2 |
Mandibular, Inflammation, Chronic | |
Active | 1 |
Mediastinal, Fibrosis | 1 |
Mediastinal, Hyperplasia, Lymphoid | 2 3 |
Mediastinal, Inflammation, Chronic | |
Active | 1 |
Pancreatic, Fibrosis | 2 |
Pancreatic, Inflammation, Chronic | |
Active | 2 |
Renal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | 2 |
Depletion Lymphoid | 3 |
Fibrosis | 2 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 1 1 1|
Inflammation, Chronic Active | 2 |
Pigmentation | 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 2 3 2 |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Thymus | + + + M + + + + M + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 5| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 3| 2| 5| 3| 3| 3| 8| 3| 3| 3| 0| 3| 3| 3| 0| 3| 3| 5| 2| 3| 3| 3| 5|
| 1| 3| 1| 2| 0| 1| 0| 1| 6| 1| 0| 1| 1| 1| 1| 1| 3| 1| 1| 0| 8| 1| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Autolysis | |
Depletion Lymphoid | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + M + + + M + + + + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
Glands, Inflammation, Acute | 1 1 1 1|
Nasolacrimal Duct, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Autolysis | 3 3 |
Inflammation, Chronic | 1 1 1 |
Polyarteritis | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 7| 5| 7|
DAY ON TEST | 3| 5| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| 5| 3| 3| 1| 3|
| 1| 3| 2| 1| 3| 1| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 0| 0| 2| 2| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + M + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + M + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 |
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Autolysis | |
Clear Cell Focus | |
Eosinophilic Focus | 1 |
Fatty Change | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 2 1|
Mixed Cell Focus | 2 |
Necrosis, Coagulative | 1 1 |
Necrosis | 1 |
Oval Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosis | 2 1 1 |
Necrosis | 3 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 7| 5| 7|
DAY ON TEST | 3| 5| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| 5| 3| 3| 1| 3|
| 1| 3| 2| 1| 3| 1| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 0| 0| 2| 2| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Inflammation, Chronic | |
Sublingual Gland, Inflammation, | |
Chronic | 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Necrosis | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M M M + + M + + M + + + + + + M + + M + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + I + + + + + + + +|
Pars Distalis, Angiectasis | 2 1 |
Pars Distalis, Hyperplasia | 2 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 7| 5| 7|
DAY ON TEST | 3| 5| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| 5| 3| 3| 1| 3|
| 1| 3| 2| 1| 3| 1| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 0| 0| 2| 2| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Pigmentation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | 2 2 3 1 1 3 2 1 1 1|
Cyst, Multiple | 2 |
Hemorrhage | 1 1 2 1 1 |
Periovarian Tissue, Necrosis | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 3 |
Hydrometra | 4 2 2 2 4 2 |
Thrombosis | 4 |
Cervix, Inflammation, Acute | |
Endometrium, Hyperplasia | 3 2 2 3 2 3 2 2 2 2 2 1 2 2 2 2 1 2 4 4 2 3 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | 2 2 1 2 1 1 2 1 2 1 1 1 2 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Inflammation, Chronic | |
Active | |
Mediastinal, Fibrosis | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Inflammation, Chronic | |
Active | |
Pancreatic, Fibrosis | |
Pancreatic, Inflammation, Chronic | |
Active | |
Renal, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | |
Depletion Lymphoid | |
Fibrosis | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation, Chronic Active | |
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + M + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | |
Hematopoietic Cell Proliferation | 1 1 2 |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Thymus | + + + + I I + + + + + + + + + + + M + I + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 7| 5| 7|
DAY ON TEST | 3| 5| 3| 3| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| 5| 3| 3| 1| 3|
| 1| 3| 2| 1| 3| 1| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 0| 0| 2| 2| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Autolysis | |
Depletion Lymphoid | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 1 1|
Glands, Inflammation, Acute | 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | |
Inflammation, Chronic | 1 1 1 |
Polyarteritis | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 0| 5| 4| 7| | |
DAY ON TEST | 3| 3| 3| 5| 7| 3| 8| 3| 5| 3| | |
| 1| 1| 2| 0| 3| 1| 4| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 55 |
Autolysis | 4 | 2 3.5|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Autolysis | 3 2 | 4 3.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | 4 | 3 3.7|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Autolysis | 4 | 3 2.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | 3 | 3 3.7|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | 3 | 3 3.7|
Hyperplasia, Lymphoid | | 1 2.0|
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | 3 4 | 4 3.8|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Autolysis | 2 | 1 2.0|
Clear Cell Focus | 1 | 5 1.6|
Eosinophilic Focus | | 2 1.0|
Fatty Change | 1 | 1 1.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 | 26 1.1|
Mixed Cell Focus | 1 | 3 1.3|
Necrosis, Coagulative | | 2 1.0|
Necrosis | 1 | 2 1.0|
Oval Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Fibrosis | | 6 1.5|
Necrosis | | 5 1.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 0| 5| 4| 7| | |
DAY ON TEST | 3| 3| 3| 5| 7| 3| 8| 3| 5| 3| | |
| 1| 1| 2| 0| 3| 1| 4| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Autolysis | 2 | 1 2.0|
Fibrosis | | 1 4.0|
Inflammation, Chronic | | 5 1.0|
Inflammation, Chronic Active | | 2 2.5|
Acinus, Atrophy | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Parotid Gland, Inflammation, Chronic | 2 | 3 1.3|
Sublingual Gland, Inflammation, | | |
Chronic | 1 | 7 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 1 | 51 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + M + + + | 59 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic Active | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Autolysis | 3 | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Necrosis | | 1 1.0|
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 7 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Autolysis | 2 | 1 2.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M M + M + | 39 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M M + + | 56 |
Pars Distalis, Angiectasis | | 3 1.3|
Pars Distalis, Hyperplasia | 2 | 10 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 0| 5| 4| 7| | |
DAY ON TEST | 3| 3| 3| 5| 7| 3| 8| 3| 5| 3| | |
| 1| 1| 2| 0| 3| 1| 4| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 1 | 4 1.0|
C-Cell, Hyperplasia | 1 | 1 1.0|
Follicular Cell, Hyperplasia | | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Cyst | 1 1 2 3 3 1 | 25 1.8|
Cyst, Multiple | | 1 2.0|
Hemorrhage | 1 1 1 | 12 1.4|
Periovarian Tissue, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | | 3 2.0|
Hydrometra | 3 3 3 4 | 12 2.8|
Thrombosis | | 1 4.0|
Cervix, Inflammation, Acute | 2 | 1 2.0|
Endometrium, Hyperplasia | 2 2 2 1 3 2 2 | 55 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Sternal, Myelofibrosis | 1 2 1 2 2 3 | 36 1.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + M + + + | 57 |
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Mandibular, Inflammation, Chronic | | |
Active | 1 | 2 1.0|
Mediastinal, Fibrosis | | 1 1.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.5|
Mediastinal, Inflammation, Chronic | | |
Active | | 1 1.0|
Pancreatic, Fibrosis | | 1 2.0|
Pancreatic, Inflammation, Chronic | | |
Active | | 1 2.0|
Renal, Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 0| 5| 4| 7| | |
DAY ON TEST | 3| 3| 3| 5| 7| 3| 8| 3| 5| 3| | |
| 1| 1| 2| 0| 3| 1| 4| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + | 58 |
Angiectasis | 2 | 1 2.0|
Autolysis | | 1 2.0|
Depletion Lymphoid | | 1 3.0|
Fibrosis | | 1 2.0|
Hyperplasia, Lymphoid | | 2 3.0|
Infiltration Cellular, Histiocyte | 1 1 | 8 1.0|
Inflammation, Chronic Active | | 1 2.0|
Pigmentation | 1 1 | 8 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Depletion Lymphoid | 4 | 1 4.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 7 2.0|
Hyperplasia, Lymphoid | 1 | 3 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 53 |
Autolysis | 2 | 1 2.0|
Depletion Lymphoid | 4 | 1 4.0|
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + | 54 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Autolysis | 1 | 1 1.0|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 | 50 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Acute | 1 | 9 1.0|
Glands, Inflammation, Acute | | 5 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 0| 5| 4| 7| | |
DAY ON TEST | 3| 3| 3| 5| 7| 3| 8| 3| 5| 3| | |
| 1| 1| 2| 0| 3| 1| 4| 6| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasolacrimal Duct, Inflammation, | | |
Acute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 | 56 1.0|
Renal Tubule, Regeneration | 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Autolysis | 4 | 3 3.3|
Inflammation, Chronic | 1 | 7 1.0|
Polyarteritis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 5| 8| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 0|
| 7| 3| 1| 7| 7| 7| 7| 7| 7| 7| 3| 9| 6| 6| 7| 3| 7| 7| 6| 0| 6| 6| 3| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 |
Eosinophilic Focus | 1 1 |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 2 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis | 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 2 1 1 |
Inflammation, Chronic | 2 1 1 |
Necrosis, Coagulative | |
Necrosis | 1 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cytoplasmic Alteration | 1 1 |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Submandibular Gland, Atrophy | 2 2 |
Submandibular Gland, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 5| 8| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 0|
| 7| 3| 1| 7| 7| 7| 7| 7| 7| 7| 3| 9| 6| 6| 7| 3| 7| 7| 6| 0| 6| 6| 3| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic | 2 1 1 1 1 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + M M + M M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + I + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 2 1 2 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 1 |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + |
Cyst | 1 |
Cyst, Multiple | 3 |
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 5| 8| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 0|
| 7| 3| 1| 7| 7| 7| 7| 7| 7| 7| 3| 9| 6| 6| 7| 3| 7| 7| 6| 0| 6| 6| 3| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Pigmentation | 1 |
Duct, Dilatation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + M + + + + + + +|
Cyst | 3 3 2 2 2 1 1 1 3|
Hemorrhage | |
Periovarian Tissue, Cyst | |
Periovarian Tissue, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 |
Infarct | |
Metaplasia, Osseous | 1 |
Endometrium, Hyperplasia | 3 3 2 2 2 2 2 3 2 2 2 2 3 3 2 3 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Sternal, Hyperplasia | 2 |
Sternal, Myelofibrosis | 1 1 2 1 1 2 2 2 3 1 1 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M|
Mandibular, Hyperplasia, Lymphoid | 3 |
Mandibular, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + M|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | 2 1 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + M + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + M + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 2| 7| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 5| 8| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 0|
| 7| 3| 1| 7| 7| 7| 7| 7| 7| 7| 3| 9| 6| 6| 7| 3| 7| 7| 6| 0| 6| 6| 3| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Glomerulosclerosis | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1 1 1 1|
Metaplasia, Osseous | 1 |
Renal Tubule, Degeneration, Hyaline | 2 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 2| 6| 7| 6| 7| 7| 4|
DAY ON TEST | 3| 1| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 3| 6| 0| 8| 3| 6| 3| 3| 5|
| 6| 8| 0| 7| 6| 0| 6| 6| 6| 6| 2| 6| 0| 6| 6| 6| 7| 7| 6| 1| 6| 6| 6| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + M + + I + + + + + + + + + + + + |
Autolysis | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Clear Cell Focus | 1 |
Eosinophilic Focus | |
Fatty Change | 1 |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis | 1 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 1 1 1 |
Inflammation, Chronic | 1 1 |
Necrosis, Coagulative | 3 |
Necrosis | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Cyst | 4 |
Cytoplasmic Alteration | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Submandibular Gland, Atrophy | |
Submandibular Gland, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 2| 6| 7| 6| 7| 7| 4|
DAY ON TEST | 3| 1| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 3| 6| 0| 8| 3| 6| 3| 3| 5|
| 6| 8| 0| 7| 6| 0| 6| 6| 6| 6| 2| 6| 0| 6| 6| 6| 7| 7| 6| 1| 6| 6| 6| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 |
Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | |
Pigmentation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + I + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + M M + M + + + + + + + + |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 1 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 1 |
Inflammation, Chronic Active | 1 1 |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + +|
Cyst | |
Cyst, Multiple | 2 2|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 2| 6| 7| 6| 7| 7| 4|
DAY ON TEST | 3| 1| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 3| 6| 0| 8| 3| 6| 3| 3| 5|
| 6| 8| 0| 7| 6| 0| 6| 6| 6| 6| 2| 6| 0| 6| 6| 6| 7| 7| 6| 1| 6| 6| 6| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1|
Pigmentation | 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + M + + + + + + + + + + + + + + +|
Cyst | 2 3 4 2 3 3 4 2 |
Hemorrhage | 2 2 |
Periovarian Tissue, Cyst | 4|
Periovarian Tissue, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 4 3 3 3 3 3 2 4|
Infarct | 3 |
Metaplasia, Osseous | |
Endometrium, Hyperplasia | 2 2 2 3 2 3 2 1 2 2 1 3 2 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Myeloid Cell, Sternal, Hyperplasia | |
Sternal, Myelofibrosis | 2 2 2 2 2 2 2 1 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + M + + I + + |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + I + + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 1 |
Hematopoietic Cell Proliferation | 4 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + M M + + M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 2| 6| 7| 6| 7| 7| 4|
DAY ON TEST | 3| 1| 5| 3| 3| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 3| 6| 0| 8| 3| 6| 3| 3| 5|
| 6| 8| 0| 7| 6| 0| 6| 6| 6| 6| 2| 6| 0| 6| 6| 6| 7| 7| 6| 1| 6| 6| 6| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Glomerulosclerosis | 4 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 |
Metaplasia, Osseous | 1 |
Renal Tubule, Degeneration, Hyaline | 2 1 |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 3 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + | 48 |
Autolysis | | 1 4.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Hyperplasia, Lymphoid | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 52 |
Clear Cell Focus | | 2 1.5|
Eosinophilic Focus | | 2 1.0|
Fatty Change | | 2 1.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Chronic | | 2 1.0|
Inflammation, Chronic Active | 1 1 1 | 29 1.0|
Mixed Cell Focus | 3 | 1 3.0|
Necrosis | | 12 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Fibrosis | 1 2 | 8 1.3|
Inflammation, Chronic | | 5 1.2|
Necrosis, Coagulative | | 1 3.0|
Necrosis | 1 2 | 6 1.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Cyst | 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cytoplasmic Alteration | | 3 1.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Submandibular Gland, Atrophy | | 2 2.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 2 1 1 | 34 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 2 1.0|
Mineralization | | 3 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Inflammation, Chronic Active | 1 | 4 1.0|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 51 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | | 1 1.0|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 45 |
Hyperplasia | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + M M | 39 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 49 |
Pars Distalis, Angiectasis | 2 | 4 1.8|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | 2 2 | 11 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
Cyst | | 2 1.5|
Inflammation, Chronic Active | | 3 1.0|
C-Cell, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 1 | 8 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + | 7 |
Cyst | | 1 1.0|
Cyst, Multiple | 2 | 4 2.3|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | | 2 1.0|
Pigmentation | 1 | 3 1.0|
Duct, Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 51 |
Cyst | 2 4 1 | 20 2.4|
Hemorrhage | | 2 2.0|
Periovarian Tissue, Cyst | | 1 4.0|
Periovarian Tissue, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 54 |
Hydrometra | 4 4 | 13 3.1|
Infarct | | 1 3.0|
Metaplasia, Osseous | | 1 1.0|
Endometrium, Hyperplasia | 2 3 2 2 2 2 3 2 | 46 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Myeloid Cell, Sternal, Hyperplasia | | 1 2.0|
Sternal, Myelofibrosis | 1 1 4 2 2 1 2 | 32 1.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 47 |
Mandibular, Hyperplasia, Lymphoid | | 1 3.0|
Mandibular, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 46 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia, Lymphoid | | 3 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 51 |
Depletion Lymphoid | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| | |
| 7| 7| 7| 7| 7| 7| 7| 3| 7| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T |
ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | A |
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 3 4.0|
Hyperplasia, Lymphoid | 2 | 4 1.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + M M + | 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 52 |
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Thalamus, Mineralization | 1 1 1 1 1 1 | 25 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Inflammation, Chronic Active | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Inflammation, Acute | 1 1 | 15 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Glomerulosclerosis | | 1 4.0|
Inflammation, Chronic | 1 1 1 1 1 1 | 40 1.1|
Metaplasia, Osseous | | 2 1.0|
Renal Tubule, Degeneration, Hyaline | | 3 1.7|
Renal Tubule, Regeneration | 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Autolysis | | 1 3.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 6| 0| 7| 7| 7| 4| 7| 4| 0| 7| 7| 7| 6| 4| 7| 0| 7| 7| 4| 6| 7| 4| 5| 7|
DAY ON TEST | 3| 6| 0| 3| 3| 3| 3| 3| 0| 1| 3| 3| 3| 0| 5| 3| 0| 0| 3| 5| 7| 3| 5| 2| 3|
| 3| 7| 6| 6| 6| 3| 7| 3| 0| 3| 3| 3| 3| 9| 3| 3| 9| 5| 3| 3| 7| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + + + + + + A M + + + + + + + M + + +|
Autolysis | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + A + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + A + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | 2 |
Fatty Change | |
Infarct | 4 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | 1 |
Necrosis, Coagulative | |
Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 2 |
Hemorrhage | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | |
Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cytoplasmic Alteration | 1 |
Fibrosis | |
Inflammation, Chronic Active | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 6| 0| 7| 7| 7| 4| 7| 4| 0| 7| 7| 7| 6| 4| 7| 0| 7| 7| 4| 6| 7| 4| 5| 7|
DAY ON TEST | 3| 6| 0| 3| 3| 3| 3| 3| 0| 1| 3| 3| 3| 0| 5| 3| 0| 0| 3| 5| 7| 3| 5| 2| 3|
| 3| 7| 6| 6| 6| 3| 7| 3| 0| 3| 3| 3| 3| 9| 3| 3| 9| 5| 3| 3| 7| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic | 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 2 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1|
Hyperkeratosis | 1 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation | 1 |
Necrosis | |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
Fibrosis | 1 |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M M + M + + M + M|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + M + + + + M + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + +|
Cyst Multilocular | |
Inflammation, Chronic Active | 2 |
Polyarteritis | 2 |
Ultimobranchial Cyst | X |
Follicular Cell, Hyperplasia | 3 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + |
Cyst | |
Inflammation, Chronic | |
Pigmentation | 1 1 1 1 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 6| 0| 7| 7| 7| 4| 7| 4| 0| 7| 7| 7| 6| 4| 7| 0| 7| 7| 4| 6| 7| 4| 5| 7|
DAY ON TEST | 3| 6| 0| 3| 3| 3| 3| 3| 0| 1| 3| 3| 3| 0| 5| 3| 0| 0| 3| 5| 7| 3| 5| 2| 3|
| 3| 7| 6| 6| 6| 3| 7| 3| 0| 3| 3| 3| 3| 9| 3| 3| 9| 5| 3| 3| 7| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | |
Cyst | 1 2 2 2 2 1 2 4 1 |
Hemorrhage | 2 2 |
__________________________________________________________________________|
Uterus | + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hydrometra | 3 2 3 4 4|
Endometrium, Hyperplasia | 2 2 2 3 2 2 2 3 2 3 1 2 3 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | 2 2 2 1 1 1 1 1 2 1 3 2 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + M + + + + +|
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + A + + + + + + M + + + + +|
Angiectasis | |
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | |
Thrombosis | 2 |
__________________________________________________________________________|
Spleen | + + M + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + M +|
Depletion Lymphoid | 3 |
Hyperplasia, Lymphoid | 2 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + M + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Epidermis, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 6| 0| 7| 7| 7| 4| 7| 4| 0| 7| 7| 7| 6| 4| 7| 0| 7| 7| 4| 6| 7| 4| 5| 7|
DAY ON TEST | 3| 6| 0| 3| 3| 3| 3| 3| 0| 1| 3| 3| 3| 0| 5| 3| 0| 0| 3| 5| 7| 3| 5| 2| 3|
| 3| 7| 6| 6| 6| 3| 7| 3| 0| 3| 3| 3| 3| 9| 3| 3| 9| 5| 3| 3| 7| 3| 3| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 1 1 1 1 1 1|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 2 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 1 |
__________________________________________________________________________|
Nose | + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 1 1 1 |
Vomeronasal Organ, Inflammation, | |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 |
Papilla, Necrosis | |
Renal Tubule, Atrophy | |
Renal Tubule, Regeneration | 1 2 1 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 5| 6| 3| 3| 0| 2| 3| 5| 3| 6| 1| 5| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 3| 0| 0| 3| 0| 7| 3| 3| 3| 1| 3| 0| 3| 2| 4| 0| 3| 3| 3| 3| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + M + + + + + + + + +|
Autolysis | 4 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Autolysis | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Autolysis | 2 |
Hyperplasia, Lymphoid | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 |
Clear Cell Focus | 1 |
Eosinophilic Focus | 1 1 1 1 1 1 |
Fatty Change | 1 1 |
Infarct | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | |
Necrosis, Coagulative | 1 1 |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosis | 2 2 1 1 |
Hemorrhage | 2 |
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active | 2 |
Necrosis, Coagulative | 2 2 |
Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + M M + + + + + + + + + + +|
Cyst | 4 |
Cytoplasmic Alteration | |
Fibrosis | |
Inflammation, Chronic Active | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 5| 6| 3| 3| 0| 2| 3| 5| 3| 6| 1| 5| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 3| 0| 0| 3| 0| 7| 3| 3| 3| 1| 3| 0| 3| 2| 4| 0| 3| 3| 3| 3| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | 1 2 1 1 1 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Inflammation | |
Necrosis | 1 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Fibrosis | |
Inflammation, Chronic Active | 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M M M + M M + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + M M + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M + M + M + + + M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Cyst Multilocular | 2 |
Inflammation, Chronic Active | |
Polyarteritis | |
Ultimobranchial Cyst | |
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + |
Cyst | |
Inflammation, Chronic | |
Pigmentation | 1 1 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 5| 6| 3| 3| 0| 2| 3| 5| 3| 6| 1| 5| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 3| 0| 0| 3| 0| 7| 3| 3| 3| 1| 3| 0| 3| 2| 4| 0| 3| 3| 3| 3| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Angiectasis | 2 |
Cyst | 2 3 1 1 2 2|
Hemorrhage | 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hydrometra | 3 3 2 2 2 3 2 4 |
Endometrium, Hyperplasia | 2 2 2 1 3 2 2 2 3 2 2 1 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | 1 1 1 2 1 2 2 1 3 2 1 2 3 1 1 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + + + + + + + +|
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 2 |
Depletion Lymphoid | |
Hyperplasia, Lymphoid | 2 |
Thrombosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + + + I M + + + + + + I + + + +|
Depletion Lymphoid | |
Hyperplasia, Lymphoid | |
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Epidermis, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Joint, Tarsal, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 4| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 5| 6| 3| 3| 0| 2| 3| 5| 3| 6| 1| 5| 3| 3| 3| 3| 3| 3| 3|
| 3| 4| 3| 0| 0| 3| 0| 7| 3| 3| 3| 1| 3| 0| 3| 2| 4| 0| 3| 3| 3| 3| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | |
Metaplasia, Osseous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 |
Vomeronasal Organ, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Papilla, Necrosis | 3 |
Renal Tubule, Atrophy | 1 |
Renal Tubule, Regeneration | 3 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 6| 4| 6| 3| 3| 6| 6| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + | 46 |
Autolysis | | 3 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
Autolysis | | 2 3.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Autolysis | | 2 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 56 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | 2 | 2 1.5|
Clear Cell Focus | 1 | 3 1.0|
Eosinophilic Focus | 2 | 8 1.3|
Fatty Change | | 2 1.0|
Infarct | | 1 4.0|
Inflammation, Chronic Active | 1 2 1 1 2 1 1 1 | 27 1.1|
Mixed Cell Focus | 2 | 2 1.5|
Necrosis, Coagulative | | 2 1.0|
Necrosis | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fibrosis | | 5 1.6|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 2 1.5|
Inflammation, Chronic Active | | 2 2.0|
Necrosis, Coagulative | | 2 2.0|
Necrosis | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 49 |
Cyst | | 1 4.0|
Cytoplasmic Alteration | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 6| 4| 6| 3| 3| 6| 6| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fibrosis | 4 | 1 4.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Acinus, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 51 |
Sublingual Gland, Inflammation, | | |
Chronic | 1 | 2 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 2 1 1 | 31 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Acanthosis | | 2 1.0|
Hyperkeratosis | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Inflammation, Chronic | 1 | 3 1.0|
Inflammation | | 1 1.0|
Necrosis | | 1 1.0|
Epithelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 51 |
Cardiomyopathy | | 1 1.0|
Fibrosis | | 1 1.0|
Inflammation, Chronic Active | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M | 40 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M + M M M | 32 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 50 |
Pars Distalis, Hyperplasia | 1 | 7 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Cyst Multilocular | | 1 2.0|
Inflammation, Chronic Active | 1 | 2 1.5|
Polyarteritis | | 1 2.0|
Ultimobranchial Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 1 | 7 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 6| 4| 6| 3| 3| 6| 6| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 9 |
Cyst | 2 | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
Pigmentation | 1 | 7 1.0|
Duct, Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 50 |
Angiectasis | | 1 2.0|
Cyst | 2 2 4 | 18 2.0|
Hemorrhage | | 4 2.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 53 |
Angiectasis | | 2 2.0|
Hydrometra | 3 | 14 2.9|
Endometrium, Hyperplasia | 2 1 2 2 2 2 3 2 | 40 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Sternal, Myelofibrosis | 1 2 2 1 1 1 2 | 36 1.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 48 |
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 47 |
Angiectasis | | 1 2.0|
Depletion Lymphoid | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Depletion Lymphoid | | 1 2.0|
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + | 45 |
Depletion Lymphoid | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 0| 3| 3| 3| 3| 3| 3| 5| 3| | |
| 6| 4| 6| 3| 3| 6| 6| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 55 |
Cyst Epithelial Inclusion | | 1 |
Epidermis, Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 51 |
Joint, Tarsal, Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 51 |
Thalamus, Mineralization | 1 1 1 1 1 1 | 29 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 52 |
Infiltration Cellular, Histiocyte | | 3 1.3|
Inflammation, Chronic Active | 3 | 1 3.0|
Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Inflammation, Acute | 1 1 1 1 1 | 16 1.0|
Vomeronasal Organ, Inflammation, | | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 51 |
Inflammation, Chronic | 1 1 1 1 1 2 1 1 1 | 45 1.1|
Papilla, Necrosis | | 1 3.0|
Renal Tubule, Atrophy | | 1 1.0|
Renal Tubule, Regeneration | | 4 1.8|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Autolysis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 2|
DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 0| 2| 6| 2| 3| 3| 2| 2| 5| 2| 2| 4| 3| 3| 3| 0| 5| 3|
| 9| 9| 9| 9| 3| 9| 9| 3| 9| 2| 9| 0| 0| 9| 9| 3| 9| 9| 9| 0| 2| 0| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Pigmentation | 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Pigmentation | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Lymphoid | 2 4 |
Epithelium, Pigmentation | 2 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus | 2 2 1 1 |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 1 1 |
Hemorrhage | 1 |
Inflammation, Chronic Active | 1 1 |
Necrosis | 1 4 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Atrophy | 1 |
Parotid Gland, Inflammation, Chronic | 2 1 |
Sublingual Gland, Inflammation, | |
Chronic | 1 1 |
Submandibular Gland, Inflammation, | |
Chronic | 2 1 1 1 1 2 2 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 2|
DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 0| 2| 6| 2| 3| 3| 2| 2| 5| 2| 2| 4| 3| 3| 3| 0| 5| 3|
| 9| 9| 9| 9| 3| 9| 9| 3| 9| 2| 9| 0| 0| 9| 9| 3| 9| 9| 9| 0| 2| 0| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Hyperkeratosis | 1 1 |
Hyperplasia, Basal Cell | 2 |
Inflammation, Chronic Active | 1 |
Ulcer, Acute | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 1 1 |
Epithelium, Hyperplasia | |
Epithelium, Pigmentation | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic Active | 1 |
Endothelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + M + + + + + M M + M M M + M M M + + M M|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 2 |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Hyperplasia | 1 2 1 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Cyst, Multiple | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 2|
DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 0| 2| 6| 2| 3| 3| 2| 2| 5| 2| 2| 4| 3| 3| 3| 0| 5| 3|
| 9| 9| 9| 9| 3| 9| 9| 3| 9| 2| 9| 0| 0| 9| 9| 3| 9| 9| 9| 0| 2| 0| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | 2 2 3 4 2 2 4 1 |
Hemorrhage | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 4 3 2 2 1 3 2 3 3 4 3 |
Thrombosis | |
Endometrium, Hyperplasia | 2 2 3 2 2 2 2 1 2 3 1 1 2 1 2 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | 2 2 2 2 1 4 1 1 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 |
Pigmentation | 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 |
Endothelium, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + I + + M + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + M + + + + + + + + + + + + + + +|
Sebaceous Gland, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 2|
DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 0| 2| 6| 2| 3| 3| 2| 2| 5| 2| 2| 4| 3| 3| 3| 0| 5| 3|
| 9| 9| 9| 9| 3| 9| 9| 3| 9| 2| 9| 0| 0| 9| 9| 3| 9| 9| 9| 0| 2| 0| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
Glands, Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Metaplasia, Osseous | 1 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 3| 5| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 5| 3| 5| 3| 3| 3| 5|
| 2| 3| 0| 3| 0| 7| 0| 2| 2| 0| 0| 2| 0| 0| 0| 0| 1| 2| 3| 2| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M M + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Pigmentation | 1 1 1 1 1|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Pigmentation | 1 1 1|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | |
Epithelium, Pigmentation | 1 1 1 1 2|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus | 2 1 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | 2 |
Necrosis, Coagulative | 1 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 2 |
Hemorrhage | |
Inflammation, Chronic Active | 1 |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Atrophy | |
Parotid Gland, Inflammation, Chronic | 2 |
Sublingual Gland, Inflammation, | |
Chronic | 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 3| 5| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 5| 3| 5| 3| 3| 3| 5|
| 2| 3| 0| 3| 0| 7| 0| 2| 2| 0| 0| 2| 0| 0| 0| 0| 1| 2| 3| 2| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + M + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | |
Inflammation, Chronic Active | 1 |
Ulcer, Acute | |
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Mineralization | |
Epithelium, Hyperplasia | 2 2 |
Epithelium, Pigmentation | 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic Active | |
Endothelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + + + + + M + M + + M M M M + + M + M|
Inflammation, Chronic | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 1 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 1 1 |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 2 1 1 3 1 1 4 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + |
Cyst, Multiple | 2 |
Pigmentation | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 3| 5| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 5| 3| 5| 3| 3| 3| 5|
| 2| 3| 0| 3| 0| 7| 0| 2| 2| 0| 0| 2| 0| 0| 0| 0| 1| 2| 3| 2| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 1 2 |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 3 2 1 2 1 |
Hemorrhage | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 3 2 2 4 3 2 4 3 2 |
Thrombosis | |
Endometrium, Hyperplasia | 2 2 2 4 2 2 2 2 2 2 2 3 2 2 2 2 3 2 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | 1 1 2 1 1 1 2 2 1 2 1 1 1 1 1 2 2 1 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mandibular, Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Depletion Lymphoid | |
Infiltration Cellular, Histiocyte | 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
Endothelium, Hyperplasia | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 0| 3| 5| 3| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 5| 3| 5| 3| 3| 3| 5|
| 2| 3| 0| 3| 0| 7| 0| 2| 2| 0| 0| 2| 0| 0| 0| 0| 1| 2| 3| 2| 0| 0| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 1 1 1 |
Glands, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Metaplasia, Osseous | |
Renal Tubule, Regeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 5| 3| 3| 5| 3| 3| 3| 3| | |
| 0| 9| 3| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A |
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 57 |
Autolysis | | 1 3.0|
Inflammation, Chronic | 1 | 3 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Epithelium, Pigmentation | 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Epithelium, Pigmentation | 1 | 6 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 3 2.7|
Epithelium, Pigmentation | 1 1 | 9 1.2|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Epithelium, Pigmentation | | 2 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | 1 1 | 2 1.0|
Eosinophilic Focus | 1 1 | 8 1.4|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 1 | 3 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 37 1.0|
Mixed Cell Focus | | 1 2.0|
Necrosis, Coagulative | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fibrosis | | 3 1.3|
Hemorrhage | | 1 1.0|
Inflammation, Chronic Active | | 3 1.0|
Necrosis | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 | 4 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Parotid Gland, Atrophy | | 1 1.0|
Parotid Gland, Inflammation, Chronic | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 5| 3| 3| 5| 3| 3| 3| 3| | |
| 0| 9| 3| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A |
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Sublingual Gland, Inflammation, | | |
Chronic | 1 | 4 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 2 1 1 1 1 | 50 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Acanthosis | 1 | 4 1.5|
Hyperkeratosis | 1 | 4 1.3|
Hyperplasia, Basal Cell | | 1 2.0|
Inflammation, Chronic Active | 1 | 3 1.0|
Ulcer, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 2 1.0|
Epithelium, Hyperplasia | | 2 2.0|
Epithelium, Pigmentation | 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Endothelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + M + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + M + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + I + | 55 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 57 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M I M M M + M + M M | 30 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + | 59 |
Pars Distalis, Angiectasis | 1 | 3 1.3|
Pars Distalis, Cyst | | 1 1.0|
Pars Distalis, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | 1 | 9 1.2|
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 5| 3| 3| 5| 3| 3| 3| 3| | |
| 0| 9| 3| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A |
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 2 1 | 16 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 7 |
Cyst, Multiple | 2 | 2 2.0|
Pigmentation | 1 | 4 1.0|
Duct, Dilatation | 2 1 | 4 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Cyst | 1 2 3 2 1 2 | 22 2.1|
Hemorrhage | 1 | 3 1.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Angiectasis | 3 | 1 3.0|
Hydrometra | 1 3 2 | 24 2.7|
Thrombosis | 3 | 1 3.0|
Endometrium, Hyperplasia | 1 1 2 2 1 3 2 2 1 1 | 50 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Sternal, Myelofibrosis | 2 2 1 2 1 1 1 | 37 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mandibular, Hyperplasia, Lymphoid | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Angiectasis | 1 | 1 1.0|
Depletion Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 | 5 1.0|
Pigmentation | 1 | 5 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia, Lymphoid | | 5 2.0|
Endothelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 57 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 5| 3| 3| 5| 3| 3| 3| 3| | |
| 0| 9| 3| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T |
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | A |
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | L |
PPM FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Sebaceous Gland, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 | 50 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Acute | 1 1 1 | 11 1.0|
Glands, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Chronic | 1 2 2 1 2 2 1 1 1 | 57 1.1|
Metaplasia, Osseous | | 1 1.0|
Renal Tubule, Regeneration | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Inflammation, Chronic | 1 | 7 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 6| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 2| 2| 5| 2| 5| 5| 2| 2| 0| 2| 2| 2| 2| 5| 5| 6| 2| 2| 2| 1| 2|
| 8| 9| 9| 9| 9| 9| 7| 9| 5| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 4| 9| 9| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Gallbladder | + M M + + M + + + + + + + M + + + + + M M + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Clear Cell Focus | |
Cyst Multilocular | |
Eosinophilic Focus | 1 1 2 |
Fatty Change | 2 1 1 1 2 2 2 1 2 2 1 2 1 1 2 1 2 1|
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 2 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 |
Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | 1 |
Hemorrhage | 2 |
Inflammation, Chronic | 1 |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 6| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 2| 2| 5| 2| 5| 5| 2| 2| 0| 2| 2| 2| 2| 5| 5| 6| 2| 2| 2| 1| 2|
| 8| 9| 9| 9| 9| 9| 7| 9| 5| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 4| 9| 9| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Submandibular Gland, Inflammation | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Mineralization | |
__________________________________________________________________________|
Tongue | + |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + M + + + M + M + M + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Follicle, Cyst | 1 |
Follicle, Cyst, Multiple | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + |
Cyst | 3 |
Cyst, Multiple | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 3 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 6| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 2| 2| 5| 2| 5| 5| 2| 2| 0| 2| 2| 2| 2| 5| 5| 6| 2| 2| 2| 1| 2|
| 8| 9| 9| 9| 9| 9| 7| 9| 5| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 4| 9| 9| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 3 3 3 3 2 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Pigmentation | 1 1 1 1 |
Polyarteritis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
__________________________________________________________________________|
Thymus | M + + + + M + + + + + + M + M + + + + M + + + + +|
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + I + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 1 |
Glands, Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 6| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 2| 2| 2| 2| 2| 5| 2| 5| 5| 2| 2| 0| 2| 2| 2| 2| 5| 5| 6| 2| 2| 2| 1| 2|
| 8| 9| 9| 9| 9| 9| 7| 9| 5| 5| 9| 9| 9| 9| 9| 9| 9| 7| 5| 4| 9| 9| 9| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Metaplasia, Osseous | |
Renal Tubule, Mineralization | 1 |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Calculus Gross Observation | X |
Fibrosis | 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 4 |
Ulcer | 3 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 1| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 3| 5| 2| 2| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 2| 3| 2|
| 4| 9| 9| 9| 0| 0| 5| 9| 9| 0| 0| 9| 5| 0| 0| 0| 0| 0| 0| 7| 7| 0| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 1 1 1 1 1 |
Cyst Multilocular | 2 |
Eosinophilic Focus | 1 2 |
Fatty Change | 1 2 1 1 1 1 2 2 2 1 1|
Inflammation, Acute | 1 |
Inflammation, Chronic Active | 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 2 |
Hemorrhage | 2 3 |
Inflammation, Chronic | 1 |
Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Inflammation, | |
Chronic | 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 1| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 3| 5| 2| 2| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 2| 3| 2|
| 4| 9| 9| 9| 0| 0| 5| 9| 9| 0| 0| 9| 5| 0| 0| 0| 0| 0| 0| 7| 7| 0| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Submandibular Gland, Inflammation | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + M + + M M + + + M + M M M M + M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Follicle, Cyst | |
Follicle, Cyst, Multiple | 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + |
Cyst | |
Cyst, Multiple | 3 4 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 1| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 3| 5| 2| 2| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 2| 3| 2|
| 4| 9| 9| 9| 0| 0| 5| 9| 9| 0| 0| 9| 5| 0| 0| 0| 0| 0| 0| 7| 7| 0| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + + + M + + + + + + +|
Mediastinal, Angiectasis | 2 1 |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + M + + + + + + +|
Angiectasis | 1 1 |
Hyperplasia, Lymphoid | 4 |
Infiltration Cellular, Histiocyte | 1 1 1 |
Pigmentation | 1 1 1 |
Polyarteritis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 2 2 |
__________________________________________________________________________|
Thymus | M + + I + + + + + + + M + + + + + + + + M M + + +|
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Glands, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 1| 4| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 2| 2| 3| 3| 5| 2| 2| 3| 3| 5| 5| 3| 3| 3| 3| 3| 3| 5| 5| 3| 2| 3| 2|
| 4| 9| 9| 9| 0| 0| 5| 9| 9| 0| 0| 9| 5| 0| 0| 0| 0| 0| 0| 7| 7| 0| 9| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
0 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Metaplasia, Osseous | |
Renal Tubule, Mineralization | 1 1 1 1 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Calculus Gross Observation | |
Fibrosis | |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | |
Ulcer | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 7| 2| 2| 2| 2| 2| 2| 2| 5| 2| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + | 53 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 1 3.0|
Clear Cell Focus | 2 1 1 1 1 | 10 1.1|
Cyst Multilocular | | 1 2.0|
Eosinophilic Focus | 3 | 6 1.7|
Fatty Change | 2 1 1 2 | 33 1.5|
Inflammation, Acute | | 2 1.0|
Inflammation, Chronic Active | | 2 1.5|
Mixed Cell Focus | 2 | 1 2.0|
Necrosis, Coagulative | | 2 1.0|
Necrosis | 1 | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fibrosis | | 2 1.5|
Hemorrhage | | 3 2.3|
Inflammation, Chronic | | 2 1.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Cytoplasmic Alteration | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 7| 2| 2| 2| 2| 2| 2| 2| 5| 2| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Sublingual Gland, Inflammation, | | |
Chronic | 1 | 2 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 1 1 | 43 1.0|
Submandibular Gland, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.5|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 3 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 6 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + | 43 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 1.0|
Follicle, Cyst | | 1 1.0|
Follicle, Cyst, Multiple | | 1 2.0|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 7| 2| 2| 2| 2| 2| 2| 2| 5| 2| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 3 1.0|
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 25 |
Cyst | | 1 3.0|
Cyst, Multiple | 3 | 3 3.3|
Inflammation, Chronic | | 2 1.0|
Inflammation, Chronic Active | 2 3 1 | 13 1.5|
Duct, Dilatation | 2 2 2 2 3 | 19 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 | 6 1.0|
Inflammation, Chronic Active | 3 | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 50 |
Fibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 57 |
Mediastinal, Angiectasis | | 2 1.5|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Angiectasis | 1 1 | 6 1.0|
Hyperplasia, Lymphoid | | 1 4.0|
Infiltration Cellular, Histiocyte | | 7 1.0|
Pigmentation | | 7 1.0|
Polyarteritis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Depletion Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + M | 48 |
Cyst | | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 7| 2| 2| 2| 2| 2| 2| 2| 5| 2| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A |
0 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 | 48 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | | 2 1.5|
Alveolar Epithelium, Hyperplasia | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Inflammation, Acute | | 4 1.0|
Glands, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + | 4 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 56 1.0|
Metaplasia, Osseous | 1 | 1 1.0|
Renal Tubule, Mineralization | 1 | 6 1.0|
Renal Tubule, Regeneration | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Calculus Gross Observation | X | 2 |
Fibrosis | | 1 3.0|
Inflammation, Chronic | | 3 1.0|
Inflammation, Chronic Active | | 1 4.0|
Ulcer | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 4| 4| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 9| 3| 3| 5| 5| 3| 9| 3| 3| 5| 3|
| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 5| 7| 7| 5| 3| 7| 6| 7| 7| 7| 1| 7| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + M + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + M + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Hyperplasia, Lymphoid | 1|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | 2 |
Basophilic Focus | 2 |
Clear Cell Focus | 1 1 |
Eosinophilic Focus | 1 1 1 1 1 |
Fatty Change | 1 1 1 1 1 2 2 3 1 3 1|
Hematopoietic Cell Proliferation | 1 |
Inflammation, Chronic Active | 1 1 1|
Mixed Cell Focus | |
Necrosis, Coagulative | 1 |
Necrosis | 1 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Angiectasis | |
Fibrosis | 1 |
Hemorrhage | 2 |
Inflammation, Chronic Active | 1 |
Necrosis | 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 |
Inflammation, Chronic Active | 2 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + +|
Parotid Gland, Inflammation, Chronic | 1 |
Submandibular Gland, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 4| 4| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 9| 3| 3| 5| 5| 3| 9| 3| 3| 5| 3|
| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 5| 7| 7| 5| 3| 7| 6| 7| 7| 7| 1| 7| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + + + +|
Acanthosis | 1 |
Hyperkeratosis | 1 |
Mineralization | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic Active | 1 2 2 |
Mineralization | |
Mucosa, Mineralization | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + M I M + + M + + + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M M + M M M M + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + |
Cyst, Multiple | |
Inflammation, Chronic Active | 1 2 1 1 2 1 1 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 4| 4| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 9| 3| 3| 5| 5| 3| 9| 3| 3| 5| 3|
| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 5| 7| 7| 5| 3| 7| 6| 7| 7| 7| 1| 7| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 2 3 2 3 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Hyperplasia, Lymphoid | 2 |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hyperplasia, Lymphoid | 2 2|
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 |
Hyperplasia, Lymphoid | 2|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + I I + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 2 |
Inflammation, Chronic Active | 2|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 4| 4| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 9| 3| 3| 5| 5| 3| 9| 3| 3| 5| 3|
| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 5| 7| 7| 5| 3| 7| 6| 7| 7| 7| 1| 7| 7| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Cornea, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 2|
Medulla, Foreign Body | 1 |
Renal Tubule, Atrophy | 3 3 |
Renal Tubule, Degeneration, Hyaline | 2 |
Renal Tubule, Regeneration | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Chronic Active | 1|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 5|
| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Autolysis | |
Basophilic Focus | |
Clear Cell Focus | 1 2 |
Eosinophilic Focus | 1 2 |
Fatty Change | 1 1 1 3 2 2 1 3 1 1 2|
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active | 1 1 |
Mixed Cell Focus | 1 1 |
Necrosis, Coagulative | 1 |
Necrosis | 2 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Angiectasis | 2 |
Fibrosis | |
Hemorrhage | 2 2 2 2 2 |
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Cytoplasmic Alteration | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + + + + +|
Parotid Gland, Inflammation, Chronic | |
Submandibular Gland, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 5|
| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Chronic | 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Mineralization | 1 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic Active | 1 |
Mineralization | |
Mucosa, Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M M + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + M + M + + M + + + + M M + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | M + M + + + + + + + + + + + + +|
Cyst, Multiple | 3 3 3 4|
Inflammation, Chronic Active | 1 2 1 1 2 1 |
Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 5|
| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 3 2 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Lumbar, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + I |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M |
__________________________________________________________________________|
Skin | + I + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + M + + + |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 4| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 5|
| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
2,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Medulla, Foreign Body | |
Renal Tubule, Atrophy | 1 |
Renal Tubule, Degeneration, Hyaline | |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Calculus Micro Observation Only | X |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 0| 3| 3| 7| 1| 3| 3| 6| | |
| 7| 7| 7| 7| 7| 9| 5| 7| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + M M + I + + + + + | 44 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + I + + + + | 47 |
Autolysis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | 4 | 2 3.0|
Hyperplasia, Lymphoid | | 3 1.7|
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Autolysis | | 1 2.0|
Basophilic Focus | 1 | 2 1.5|
Clear Cell Focus | 2 | 5 1.4|
Eosinophilic Focus | 2 | 8 1.3|
Fatty Change | 1 | 23 1.6|
Hematopoietic Cell Proliferation | | 1 1.0|
Inflammation, Chronic Active | | 5 1.0|
Mixed Cell Focus | | 2 1.0|
Necrosis, Coagulative | | 2 1.0|
Necrosis | | 6 1.2|
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Angiectasis | | 1 2.0|
Fibrosis | | 1 1.0|
Hemorrhage | 2 2 | 8 2.0|
Inflammation, Chronic Active | | 1 1.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 0| 3| 3| 7| 1| 3| 3| 6| | |
| 7| 7| 7| 7| 7| 9| 5| 7| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Cytoplasmic Alteration | | 1 1.0|
Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + M + + + + + + + + | 49 |
Parotid Gland, Inflammation, Chronic | | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 2 | 34 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Acanthosis | | 1 1.0|
Hyperkeratosis | | 1 1.0|
Mineralization | | 2 1.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | 1 | 1 1.0|
Inflammation, Chronic Active | | 4 1.5|
Mineralization | 1 | 1 1.0|
Mucosa, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Inflammation, Chronic Active | 1 | 3 1.3|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Hyperplasia | 1 | 5 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 42 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M M M M + + M | 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 49 |
Pars Distalis, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + + + + + | 49 |
Cyst | 1 | 1 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 0| 3| 3| 7| 1| 3| 3| 6| | |
| 7| 7| 7| 7| 7| 9| 5| 7| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + | 24 |
Cyst, Multiple | | 4 3.3|
Inflammation, Chronic Active | | 13 1.3|
Pigmentation | | 1 1.0|
Duct, Dilatation | 2 2 2 | 18 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 51 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + M + + + + + + + + | 51 |
Lumbar, Hyperplasia, Lymphoid | | 1 2.0|
Mandibular, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mandibular, Hyperplasia, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + I + + + | 50 |
Angiectasis | 2 | 3 1.7|
Hyperplasia, Lymphoid | | 3 2.0|
Hyperplasia, Plasma Cell | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 | 3 2.7|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + | 47 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 0| 3| 3| 7| 1| 3| 3| 6| | |
| 7| 7| 7| 7| 7| 9| 5| 7| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 2.0|
Thalamus, Mineralization | 1 1 1 1 1 1 | 30 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Infiltration Cellular, Histiocyte | | 3 1.3|
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 49 |
Inflammation, Acute | 1 | 7 1.0|
__________________________________________________________________________|____________|
Trachea | + M + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | M + | 4 |
Cornea, Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 53 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 47 1.1|
Medulla, Foreign Body | | 1 1.0|
Renal Tubule, Atrophy | | 3 2.3|
Renal Tubule, Degeneration, Hyaline | | 1 2.0|
Renal Tubule, Regeneration | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Calculus Micro Observation Only | | 1 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 4|
DAY ON TEST | 3| 3| 1| 4| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 4| 3| 4| 5|
| 4| 5| 3| 1| 7| 4| 4| 4| 5| 5| 5| 4| 4| 4| 3| 5| 4| 4| 4| 5| 5| 1| 4| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + M M + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Eosinophilic Focus | 2 2 |
Fatty Change | 1 3 1 1 2 2 3 3 1 2 1 1 1 3|
Hematopoietic Cell Proliferation | |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Necrosis, Coagulative | |
Necrosis | 1 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 1 |
Hemorrhage | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 1 |
Cytoplasmic Alteration | |
Inflammation, Chronic Active | 4 |
Acinus, Atrophy | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Parotid Gland, Inflammation, Chronic | |
Sublingual Gland, Inflammation, | |
Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 |
Hyperkeratosis | 1 1 |
Hyperplasia, Basal Cell | 1 1 |
Inflammation, Chronic Active | 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 4|
DAY ON TEST | 3| 3| 1| 4| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 4| 3| 4| 5|
| 4| 5| 3| 1| 7| 4| 4| 4| 5| 5| 5| 4| 4| 4| 3| 5| 4| 4| 4| 5| 5| 1| 4| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + M + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + M + + + + + + + + |
Hyperplasia | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + M + M + + + + M M + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + M M + + + M + + + + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Cyst Multilocular | 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + +|
Cyst, Multiple | 2 3 4 4|
Inflammation, Chronic | 2 1 2 |
Inflammation, Chronic Active | 1 1 1 2 1|
Duct, Dilatation | 2 2 2 3 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
Myeloid Cell, Sternal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 4|
DAY ON TEST | 3| 3| 1| 4| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 4| 3| 4| 5|
| 4| 5| 3| 1| 7| 4| 4| 4| 5| 5| 5| 4| 4| 4| 3| 5| 4| 4| 4| 5| 5| 1| 4| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mandibular, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Granulomatous | 4 |
Pigmentation | |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 3 3 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Thymus | + M M M + + + + + M + + + + + + + + M + + |
Cyst | 1 |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M A M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Parakeratosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + M + + + + + + + + + + + + + + + + |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 3 |
Leukocytosis | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 4|
DAY ON TEST | 3| 3| 1| 4| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 1| 5| 3| 3| 3| 3| 3| 4| 3| 4| 5|
| 4| 5| 3| 1| 7| 4| 4| 4| 5| 5| 5| 4| 4| 4| 3| 5| 4| 4| 4| 5| 5| 1| 4| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Glomerulosclerosis | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 |
Renal Tubule, Pigmentation | 1 |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Calculus Gross Observation | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 5| 4| 7| 7|
DAY ON TEST | 5| 3| 5| 1| 3| 3| 3| 4| 3| 3| 9| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 9| 5| 3| 3|
| 7| 5| 7| 6| 4| 4| 5| 0| 5| 5| 9| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 1 1 1 1 1 |
Eosinophilic Focus | 1 |
Fatty Change | 3 1 1 2 1 2 1 1 1 3 2 2|
Hematopoietic Cell Proliferation | 2 |
Inflammation, Chronic Active | |
Mixed Cell Focus | 2 |
Necrosis, Coagulative | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | 1 1 |
Hemorrhage | |
Inflammation, Chronic Active | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cytoplasmic Alteration | |
Inflammation, Chronic Active | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Parotid Gland, Inflammation, Chronic | 2 2 1 1 |
Sublingual Gland, Inflammation, | |
Chronic | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 5| 4| 7| 7|
DAY ON TEST | 5| 3| 5| 1| 3| 3| 3| 4| 3| 3| 9| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 9| 5| 3| 3|
| 7| 5| 7| 6| 4| 4| 5| 0| 5| 5| 9| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + M M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M + M + + + + + M + I + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + +|
Cyst Multilocular | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + |
Cyst, Multiple | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 2 |
Duct, Dilatation | 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + M + + + + + +|
Myeloid Cell, Sternal, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + M + + + + + M M +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 5| 4| 7| 7|
DAY ON TEST | 5| 3| 5| 1| 3| 3| 3| 4| 3| 3| 9| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 9| 5| 3| 3|
| 7| 5| 7| 6| 4| 4| 5| 0| 5| 5| 9| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mandibular, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M M + + + + M + +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
Inflammation, Granulomatous | |
Pigmentation | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Depletion Lymphoid | 2 3 2 |
Hematopoietic Cell Proliferation | 2 4 2 |
Hyperplasia, Lymphoid | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + M + +|
Cyst | 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Parakeratosis | 1 |
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Leukocytosis | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + M I + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 6| 5| 4| 7| 7|
DAY ON TEST | 5| 3| 5| 1| 3| 3| 3| 4| 3| 3| 9| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3| 9| 5| 3| 3|
| 7| 5| 7| 6| 4| 4| 5| 0| 5| 5| 9| 4| 5| 5| 5| 5| 5| 4| 5| 5| 9| 5| 7| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
10,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | 2 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 5| 3| 3| 3| 0| 3| | |
| 5| 5| 5| 6| 7| 5| 5| 5| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Clear Cell Focus | | 5 1.0|
Eosinophilic Focus | 2 1 | 5 1.6|
Fatty Change | 2 3 1 4 2 1 | 32 1.8|
Hematopoietic Cell Proliferation | | 1 2.0|
Inflammation, Chronic Active | 1 1 1 | 3 1.0|
Mixed Cell Focus | | 1 2.0|
Necrosis, Coagulative | 1 | 1 1.0|
Necrosis | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fibrosis | | 3 1.0|
Hemorrhage | 2 | 2 2.0|
Inflammation, Chronic Active | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 50 |
Autolysis | | 1 1.0|
Cytoplasmic Alteration | 1 | 1 1.0|
Inflammation, Chronic Active | | 1 4.0|
Acinus, Atrophy | 1 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 50 |
Parotid Gland, Inflammation, Chronic | | 4 1.5|
Sublingual Gland, Inflammation, | | |
Chronic | 2 | 1 2.0|
Submandibular Gland, Inflammation, | | |
Chronic | 1 2 1 1 | 32 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 5| 3| 3| 3| 0| 3| | |
| 5| 5| 5| 6| 7| 5| 5| 5| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | | 2 1.0|
Hyperkeratosis | | 2 1.0|
Hyperplasia, Basal Cell | | 2 1.0|
Inflammation, Chronic Active | 1 | 4 1.3|
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Mineralization | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 50 |
Hyperplasia | 2 | 5 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 43 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + M M | 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 50 |
Pars Distalis, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 49 |
Cyst Multilocular | | 1 2.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 29 |
Cyst, Multiple | 3 3 | 6 3.2|
Inflammation, Chronic | 1 1 | 5 1.4|
Inflammation, Chronic Active | 2 | 8 1.4|
Duct, Dilatation | 2 2 | 21 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 5| 3| 3| 3| 0| 3| | |
| 5| 5| 5| 6| 7| 5| 5| 5| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 50 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + | 50 |
Seminiferous Tubule, Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 49 |
Myeloid Cell, Sternal, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + I + + | 46 |
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + I + + | 46 |
Hyperplasia, Lymphoid | 1 1 | 3 1.3|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Inflammation, Granulomatous | | 1 4.0|
Pigmentation | 1 | 1 1.0|
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 52 |
Angiectasis | | 1 1.0|
Depletion Lymphoid | 2 | 4 2.3|
Hematopoietic Cell Proliferation | | 6 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + | 42 |
Cyst | 2 | 3 1.7|
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 51 |
Parakeratosis | | 1 1.0|
Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 4| 4| 7| 7| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 3| 3| 5| 3| 3| 3| 0| 3| | |
| 5| 5| 5| 6| 7| 5| 5| 5| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A |
10,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Thalamus, Mineralization | 1 1 1 1 1 | 31 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Inflammation, Chronic Active | | 1 3.0|
Leukocytosis | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 50 |
Inflammation, Acute | 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Cyst | 1 | 1 1.0|
Glomerulosclerosis | | 1 2.0|
Inflammation, Chronic | 1 1 2 1 1 1 1 | 48 1.1|
Renal Tubule, Pigmentation | | 1 1.0|
Renal Tubule, Regeneration | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 50 |
Calculus Gross Observation | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 4| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 5| 3|
| 5| 1| 5| 1| 1| 8| 8| 1| 4| 1| 0| 0| 1| 0| 1| 4| 0| 0| 0| 7| 7| 2| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + M + + + M + + + + + +|
Autolysis | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Epithelium, Hyperplasia | 3 |
Epithelium, Pigmentation | 1 1 1 1 |
Submucosa, Epithelium, Proliferation | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | |
Epithelium, Pigmentation | 1 1 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | 2 1 |
Fatty Change | 2 4 2 2 1 1 1 1 2 3 4 |
Mixed Cell Focus | 1 1 2|
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosis | 1 2 2 2 |
Hemorrhage | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 2 |
Necrosis, Coagulative | 3 |
Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 4| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 5| 3|
| 5| 1| 5| 1| 1| 8| 8| 1| 4| 1| 0| 0| 1| 0| 1| 4| 0| 0| 0| 7| 7| 2| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cytoplasmic Alteration | |
Inflammation, Chronic | |
Duct, Concretion | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Autolysis | 4 |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic | 1 |
Epithelium, Pigmentation | 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + M + + + + + M M + + + M M + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic Active | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 4| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 5| 3|
| 5| 1| 5| 1| 1| 8| 8| 1| 4| 1| 0| 0| 1| 0| 1| 4| 0| 0| 0| 7| 7| 2| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + +|
Cyst, Multiple | 3 2 3 3 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 1 1 1 1 |
Duct, Dilatation | 2 2 2 2 2 2 3|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Sternal, Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + M + + + +|
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + M + + + +|
Angiectasis | 1 2 1 |
Infiltration Cellular, Histiocyte | 1 1 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | 4 |
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | M + + + + I + + + M + + + + M + M + + M I + + + +|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Epidermis, Inflammation, Acute | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 6| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 4| 4| 7|
DAY ON TEST | 5| 3| 5| 3| 3| 7| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 5| 5| 3|
| 5| 1| 5| 1| 1| 8| 8| 1| 4| 1| 0| 0| 1| 0| 1| 4| 0| 0| 0| 7| 7| 2| 7| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Infarct | |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + +|
__________________________________________________________________________|
Harderian Gland | + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Cyst | |
Glomerulosclerosis | 2 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Calculus Gross Observation | X X X |
Calculus Micro Observation Only | X |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3|
| 0| 1| 2| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 2| 5| 2| 2| 2| 5| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + M + +|
Autolysis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Epithelium, Hyperplasia | |
Epithelium, Pigmentation | 1 2 1 |
Submucosa, Epithelium, Proliferation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Epithelium, Pigmentation | 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 3 |
Epithelium, Pigmentation | 2 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 2 |
Epithelium, Pigmentation | 1 2 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Basophilic Focus | |
Clear Cell Focus | 2 1 |
Eosinophilic Focus | 2 1 1 |
Fatty Change | 3 2 1 1 1 1 1 1 1 3 2 2 3 2 1 3 |
Mixed Cell Focus | 2 1 1 |
Necrosis | 1 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosis | 1 1 2 2 |
Hemorrhage | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 1 |
Necrosis, Coagulative | |
Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3|
| 0| 1| 2| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 2| 5| 2| 2| 2| 5| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Cytoplasmic Alteration | 1 |
Inflammation, Chronic | |
Duct, Concretion | |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Autolysis | |
Hyperkeratosis | 1 |
Hyperplasia, Basal Cell | |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | |
Epithelium, Pigmentation | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M M + M M + + I + + I + + + + M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3|
| 0| 1| 2| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 2| 5| 2| 2| 2| 5| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + +|
Cyst, Multiple | 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 2 1 2 1 1 1|
Duct, Dilatation | 2 2 2 2 2 2 2 2 2 1 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Sternal, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + M + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Infiltration Cellular, Histiocyte | 1 1 |
Pigmentation | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Autolysis | |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + I + M M + + + + + + M M + + + + + + + + + + + M|
Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Epidermis, Inflammation, Acute | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 5| 3| 3|
| 0| 1| 2| 1| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 2| 5| 2| 2| 2| 5| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
50,000 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Infarct | 2 |
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cyst | |
Glomerulosclerosis | |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Mineralization | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Calculus Gross Observation | |
Calculus Micro Observation Only | X X |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 4| 7| | |
DAY ON TEST | 3| 2| 5| 3| 3| 3| 5| 3| 5| 3| | |
| 2| 7| 7| 2| 2| 2| 7| 2| 7| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 55 |
Autolysis | 4 | 2 4.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Epithelium, Hyperplasia | | 1 3.0|
Epithelium, Pigmentation | 1 | 8 1.1|
Submucosa, Epithelium, Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Epithelium, Pigmentation | 1 | 5 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Epithelium, Pigmentation | 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Epithelium, Pigmentation | 1 1 | 5 1.4|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Autolysis | 2 | 2 3.0|
Basophilic Focus | 1 | 1 1.0|
Clear Cell Focus | | 2 1.5|
Eosinophilic Focus | 1 1 | 7 1.3|
Fatty Change | 1 3 4 2 3 2 1 | 34 2.0|
Mixed Cell Focus | | 6 1.3|
Necrosis | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | | 8 |
Fibrosis | | 8 1.6|
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 4| 7| | |
DAY ON TEST | 3| 2| 5| 3| 3| 3| 5| 3| 5| 3| | |
| 2| 7| 7| 2| 2| 2| 7| 2| 7| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 4 1.5|
Necrosis, Coagulative | | 1 3.0|
Necrosis | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Cytoplasmic Alteration | 1 2 | 3 1.3|
Inflammation, Chronic | 1 1 | 2 1.0|
Duct, Concretion | 2 | 1 2.0|
Duct, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Submandibular Gland, Inflammation, | | |
Chronic | 1 1 1 1 1 | 42 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | 2 | 2 1.5|
Autolysis | | 1 4.0|
Hyperkeratosis | 1 | 2 1.0|
Hyperplasia, Basal Cell | 1 | 1 1.0|
Inflammation, Acute | 1 | 1 1.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
Epithelium, Pigmentation | 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
Hyperplasia | | 5 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Cyst | | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 4| 7| | |
DAY ON TEST | 3| 2| 5| 3| 3| 3| 5| 3| 5| 3| | |
| 2| 7| 7| 2| 2| 2| 7| 2| 7| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Autolysis | | 1 4.0|
Inflammation, Chronic Active | | 1 1.0|
Follicular Cell, Hyperplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Granuloma Sperm | | 1 2.0|
Inflammation, Chronic | 1 1 | 6 1.0|
Inflammation, Chronic Active | | 2 1.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 31 |
Cyst, Multiple | 2 3 | 7 2.7|
Inflammation, Chronic | 1 | 2 1.0|
Inflammation, Chronic Active | 1 1 2 | 15 1.3|
Duct, Dilatation | 2 | 19 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 | 4 1.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Sternal, Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 57 |
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + I + | 56 |
Angiectasis | | 4 1.3|
Infiltration Cellular, Histiocyte | 1 1 | 6 1.0|
Pigmentation | 1 | 5 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + M + + | 59 |
Angiectasis | | 1 1.0|
Autolysis | | 1 4.0|
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 4| 7| | |
DAY ON TEST | 3| 2| 5| 3| 3| 3| 5| 3| 5| 3| | |
| 2| 7| 7| 2| 2| 2| 7| 2| 7| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Epidermis, Inflammation, Acute | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Infarct | | 1 2.0|
Thalamus, Mineralization | 1 1 1 1 1 1 1 1 1 1 | 55 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Acute | 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 6 |
__________________________________________________________________________|____________|
Harderian Gland | | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Cyst | 1 | 1 1.0|
Glomerulosclerosis | | 1 2.0|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 | 45 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05084-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:50
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 4| 7| 4| 7| | |
DAY ON TEST | 3| 2| 5| 3| 3| 3| 5| 3| 5| 3| | |
| 2| 7| 7| 2| 2| 2| 7| 2| 7| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
50,000 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L |
PPM MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Mineralization | | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Calculus Gross Observation | | 3 |
Calculus Micro Observation Only | | 3 |
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------