TDMS Study 05084-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TURMERIC OLEORESIN
NTP Experiment-Test: 05084-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
Facility: TSI Mason Research
Chemical CAS #: 458-37-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 9
Early Deaths
Dead 3 1 3 2
Moribund 14 22 19 15
Survivors
Terminal Sacrifice 32 26 28 34
Dead 1 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (60) (60) (60) (60)
Autolysis 2 (3%) 2 (3%) 2 (3%) 3 (5%)
Hyperplasia, Glandular 1 (2%) 56 (93%)
Parasite Metazoan 22 (37%) 11 (18%) 11 (18%) 4 (7%)
Ulcer 26 (43%)
Submucosa, Lamina Propria, Inflammation,
Chronic Active 45 (75%)
Intestine Large, Colon (60) (60) (60) (59)
Autolysis 2 (3%) 2 (3%) 2 (3%)
Edema 1 (2%)
Hyperplasia, Glandular 1 (2%)
Parasite Metazoan 10 (17%) 9 (15%) 11 (18%) 1 (2%)
Epithelium, Pigmentation 8 (14%)
Intestine Large, Rectum (60) (59) (59) (60)
Autolysis 2 (3%) 2 (3%) 2 (3%) 1 (2%)
Edema 1 (2%)
Parasite Metazoan 8 (13%) 8 (14%) 3 (5%) 4 (7%)
Epithelium, Pigmentation 2 (3%)
Intestine Small, Duodenum (60) (60) (60) (60)
Autolysis 2 (3%) 2 (3%) 2 (3%) 2 (3%)
Intestine Small, Ileum (60) (60) (59) (60)
Autolysis 2 (3%) 2 (3%) 2 (3%) 3 (5%)
Hyperplasia, Lymphoid 1 (2%)
Epithelium, Pigmentation 9 (15%)
Intestine Small, Jejunum (60) (59) (60) (60)
Autolysis 2 (3%) 3 (5%) 2 (3%) 3 (5%)
Liver (60) (52) (54) (60)
Angiectasis 1 (2%) 1 (2%) 3 (5%)
Autolysis 1 (2%)
Basophilic Focus 32 (53%) 33 (63%) 30 (56%) 35 (58%)
Clear Cell Focus 8 (13%) 7 (13%) 5 (9%) 6 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Congestion 1 (2%)
Cytoplasmic Alteration 2 (4%) 2 (3%)
Degeneration 1 (2%) 1 (2%) 2 (3%)
Eosinophilic Focus 2 (3%) 1 (2%) 3 (6%) 1 (2%)
Fatty Change 9 (15%) 12 (23%) 6 (11%) 4 (7%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 10 (17%) 6 (12%) 10 (19%) 9 (15%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation 1 (2%)
Inflammation, Chronic 4 (7%) 1 (2%) 1 (2%) 4 (7%)
Inflammation, Chronic Active 23 (38%) 26 (50%) 19 (35%) 26 (43%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 5 (8%) 7 (13%) 1 (2%)
Necrosis, Coagulative 7 (12%) 2 (4%) 4 (7%) 1 (2%)
Pigmentation 1 (2%)
Bile Duct, Hyperplasia 16 (27%) 19 (37%) 11 (20%) 14 (23%)
Mesentery (5) (4) (4) (2)
Fibrosis 4 (80%) 2 (50%) 2 (50%) 1 (50%)
Inflammation, Chronic 1 (20%)
Inflammation, Chronic Active 3 (60%) 2 (50%) 1 (25%) 2 (100%)
Mineralization 2 (50%)
Necrosis, Liquifactive 1 (20%) 1 (25%) 3 (75%) 1 (50%)
Pancreas (60) (50) (50) (59)
Atrophy 1 (2%)
Cytoplasmic Alteration 2 (4%)
Ectopic Liver 1 (2%) 1 (2%)
Inflammation, Chronic 3 (5%) 3 (5%)
Inflammation, Chronic Active 24 (40%) 22 (44%) 23 (46%) 17 (29%)
Pigmentation 1 (2%)
Vacuolization Cytoplasmic 4 (7%) 6 (12%) 4 (8%) 2 (3%)
Acinus, Atrophy 24 (40%) 18 (36%) 25 (50%) 18 (31%)
Acinus, Hyperplasia 1 (2%)
Salivary Glands (60) (50) (50) (60)
Inflammation, Chronic Active 1 (2%)
Duct, Sublingual Gland, Hyperplasia 1 (2%)
Duct, Sublingual Gland, Metaplasia, Squamous 2 (4%)
Duct, Submandibular Gland, Hyperplasia 6 (10%) 5 (10%) 5 (10%) 6 (10%)
Duct, Submandibular Gland, Inflammation,
Chronic Active 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Duct, Submandibular Gland, Metaplasia,
Squamous 12 (20%) 19 (38%) 8 (16%) 10 (17%)
Parotid Gland, Atrophy 1 (2%) 1 (2%) 2 (3%)
Parotid Gland, Inflammation, Chronic Active 1 (2%)
Parotid Gland, Submandibular Gland,
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Sublingual Gland, Inflammation, Chronic 1 (2%) 1 (2%)
Sublingual Gland, Inflammation, Chronic
Active 2 (3%) 1 (2%) 3 (6%)
Sublingual Gland, Metaplasia, Squamous 1 (2%)
Submandibular Gland, Inflammation, Chronic 3 (5%) 1 (2%)
Submandibular Gland, Inflammation, Chronic
Active 16 (27%) 15 (30%) 11 (22%) 12 (20%)
Stomach, Forestomach (60) (60) (59) (60)
Acanthosis 1 (2%)
Foreign Body 1 (2%)
Hyperkeratosis 2 (3%) 5 (8%) 6 (10%) 3 (5%)
Hyperplasia, Squamous 3 (5%) 6 (10%) 7 (12%) 4 (7%)
Inflammation, Chronic Active 2 (3%) 1 (2%) 1 (2%)
Ulcer 2 (3%) 5 (8%) 2 (3%) 1 (2%)
Muscularis, Mineralization 1 (2%)
Stomach, Glandular (60) (60) (59) (60)
Autolysis 1 (2%) 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 2 (3%)
Metaplasia, Squamous 1 (2%)
Necrosis, Coagulative 1 (2%) 3 (5%)
Mucosa, Dilatation 44 (73%) 48 (80%) 45 (76%) 44 (73%)
Muscularis, Mineralization 1 (2%)
Tongue (1) (1)
Hyperplasia, Squamous 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (50) (60)
Cardiomyopathy 58 (97%) 48 (96%) 47 (94%) 58 (97%)
Atrium, Thrombosis 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (50) (51) (60)
Capsule, Fibrosis 1 (2%)
Adrenal Gland, Cortex (60) (50) (51) (59)
Angiectasis 44 (73%) 36 (72%) 37 (73%) 38 (64%)
Autolysis 1 (2%)
Congestion 2 (4%)
Degeneration 1 (2%)
Hematopoietic Cell Proliferation 2 (3%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 12 (20%) 10 (20%) 11 (22%) 9 (15%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Necrosis, Coagulative 1 (2%)
Vacuolization Cytoplasmic 22 (37%) 14 (28%) 15 (29%) 11 (19%)
Adrenal Gland, Medulla (60) (49) (50) (59)
Autolysis 1 (2%)
Hyperplasia 3 (5%) 3 (6%) 2 (4%) 3 (5%)
Necrosis, Coagulative 1 (2%)
Islets, Pancreatic (59) (50) (50) (59)
Hyperplasia 1 (2%)
Parathyroid Gland (55) (47) (49) (55)
Hyperplasia 1 (2%)
Pituitary Gland (60) (49) (52) (60)
Pars Distalis, Angiectasis 6 (10%) 5 (10%) 6 (12%) 5 (8%)
Pars Distalis, Cyst 30 (50%) 19 (39%) 21 (40%) 41 (68%)
Pars Distalis, Hyperplasia 19 (32%) 21 (43%) 14 (27%) 19 (32%)
Pars Distalis, Pigmentation 1 (2%)
Pars Intermedia, Angiectasis 1 (2%) 1 (2%) 1 (2%)
Pars Intermedia, Cyst 1 (2%) 1 (2%) 1 (2%)
Pars Intermedia, Pigmentation 1 (2%)
Rathke's Cleft, Crystals 1 (2%)
Thyroid Gland (60) (51) (52) (60)
Inflammation, Chronic Active 1 (2%)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 33 (55%) 29 (57%) 24 (46%) 29 (48%)
Follicular Cell, Cyst 1 (2%) 3 (6%) 1 (2%)
Follicular Cell, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (2)
Necrosis 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (51) (49) (58)
Hyperplasia 7 (12%) 5 (10%) 5 (10%) 7 (12%)
Inflammation, Chronic 4 (7%) 3 (6%) 6 (10%)
Inflammation, Chronic Active 32 (53%) 23 (45%) 26 (53%) 26 (45%)
Duct, Dilatation 4 (7%) 4 (8%) 2 (4%) 3 (5%)
Ovary (60) (51) (51) (60)
Cyst 2 (3%) 1 (2%) 6 (12%) 2 (3%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Periovarian Tissue, Cyst 1 (2%)
Uterus (60) (50) (50) (60)
Angiectasis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hydrometra 8 (13%) 5 (10%) 6 (12%) 7 (12%)
Inflammation, Acute 1 (2%) 3 (6%) 4 (8%)
Necrosis, Coagulative 1 (2%)
Pigmentation 1 (2%)
Cervix, Cyst 1 (2%) 2 (4%) 6 (12%)
Endometrium, Cyst 1 (2%)
Endometrium, Hyperplasia 7 (12%) 5 (10%) 7 (14%) 9 (15%)
Vagina (1) (2) (1)
Exudate 2 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (52) (60)
Sternal, Autolysis 1 (2%) 1 (2%)
Sternal, Myelofibrosis 1 (2%)
Lymph Node (60) (60) (56) (60)
Bronchial, Fibrosis 1 (2%)
Bronchial, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hemorrhage 5 (8%) 4 (7%) 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 2 (3%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Mediastinal, Pigmentation 1 (2%)
Pancreatic, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 2 (3%)
Pancreatic, Pigmentation 1 (2%) 1 (2%)
Lymph Node, Mandibular (4) (9) (6) (7)
Hemorrhage 1 (25%) 1 (17%)
Hyperplasia, Lymphoid 2 (22%)
Hyperplasia, Plasma Cell 2 (33%)
Sinus, Ectasia 1 (25%) 1 (11%) 1 (17%) 1 (14%)
Lymph Node, Mesenteric (60) (60) (56) (60)
Infiltration Cellular, Histiocyte 60 (100%) 57 (95%) 55 (98%) 55 (92%)
Pigmentation 7 (12%) 10 (17%) 6 (11%) 8 (13%)
Sinus, Ectasia 1 (2%) 59 (98%)
Spleen (60) (50) (51) (60)
Angiectasis 1 (2%)
Autolysis 1 (2%)
Cyst 1 (2%)
Depletion Lymphoid 11 (18%) 14 (28%) 8 (16%) 11 (18%)
Fibrosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (3%) 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 1 (2%)
Thymus (51) (48) (45) (50)
Cyst 3 (6%) 1 (2%) 4 (9%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (49) (49) (59)
Galactocele 3 (5%) 1 (2%) 1 (2%)
Hyperplasia 57 (95%) 47 (96%) 47 (96%) 54 (92%)
Skin (58) (50) (51) (59)
Abscess 1 (2%)
Acanthosis 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Foot, Acanthosis 2 (3%)
Foot, Hyperkeratosis 2 (3%)
Foot, Inflammation, Chronic Active 1 (2%)
Subcutaneous Tissue, Cyst Epithelial
Inclusion 2 (4%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (52) (60)
Cranium, Hyperostosis 1 (2%) 1 (2%) 1 (2%)
Cranium, Osteopetrosis 1 (2%) 2 (3%) 1 (2%)
Sternum, Osteopetrosis 2 (3%) 1 (2%) 4 (7%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (50) (60)
Gliosis 1 (2%)
Hydrocephalus 3 (5%) 3 (6%) 2 (4%)
Infarct 1 (2%) 1 (2%)
Necrosis, Coagulative 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (52) (52) (60)
Abscess 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 19 (32%) 10 (19%) 12 (23%) 20 (33%)
Inflammation, Chronic Active 3 (6%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (7%) 2 (4%) 1 (2%) 4 (7%)
Alveolus, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Artery, Mineralization 28 (47%) 19 (37%) 32 (62%) 32 (53%)
Artery, Muscularis, Hyperplasia 1 (2%)
Nose (59) (56) (52) (60)
Inflammation, Chronic Active 28 (47%) 23 (41%) 23 (44%) 35 (58%)
Metaplasia, Squamous 2 (3%) 3 (5%) 3 (6%) 1 (2%)
Lumen, Foreign Body 1 (2%) 2 (4%)
Lumen, Inflammation, Acute 1 (2%)
Mucosa, Ulcer 1 (2%) 1 (2%)
Mucosa, Submucosa, Inflammation, Chronic
Active 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 2 (3%)
Nasopharyngeal Duct, Inflammation, Acute 1 (2%) 1 (2%)
Submucosa, Glands, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (9) (10) (7) (13)
Cataract 1 (11%) 2 (20%) 3 (43%) 2 (15%)
Phthisis Bulbi 2 (22%) 1 (14%) 1 (8%)
Cornea, Inflammation, Chronic Active 1 (11%) 1 (10%)
Cornea, Neovascularization 2 (22%) 1 (10%)
Lens, Cataract 1 (8%)
Retina, Degeneration 3 (30%) 4 (57%) 3 (23%)
Lacrimal Gland (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (51) (49) (60)
Autolysis 2 (3%) 1 (2%) 2 (4%) 1 (2%)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Nephropathy 58 (97%) 49 (96%) 47 (96%) 55 (92%)
Pelvis, Inflammation, Acute 1 (2%)
Proximal Convoluted Renal Tubule,
Inflammation, Acute 1 (2%) 1 (2%)
Renal Tubule, Mineralization 5 (8%) 6 (12%) 14 (23%)
Transitional Epithelium, Hyperplasia 7 (12%) 8 (16%) 6 (12%) 10 (17%)
Transitional Epithelium, Mineralization 1 (2%) 2 (4%) 2 (3%)
Urinary Bladder (60) (48) (49) (60)
Autolysis 1 (2%) 1 (2%)
Inflammation, Chronic Active 3 (5%) 1 (2%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 2,000PPM 10,000 50,000
FEMALE FEMALE PPM FEM PPM FEM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Subserosa, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 9
Early Deaths
Moribund 26 29 32 28
Dead 6 4 3 6
Survivors
Terminal Sacrifice 18 17 15 17
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (59) (49) (49) (58)
Autolysis 1 (2%)
Hyperkeratosis 3 (5%)
Ulcer 1 (2%)
Intestine Large, Cecum (60) (59) (60) (60)
Autolysis 3 (5%) 3 (5%) 2 (3%) 3 (5%)
Erosion 1 (2%)
Hyperplasia, Glandular 1 (2%) 49 (82%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Osseous 1 (2%)
Parasite Metazoan 17 (28%) 11 (19%) 16 (27%) 2 (3%)
Polyarteritis 1 (2%)
Ulcer 1 (2%) 32 (53%)
Ulcer, Multiple 1 (2%)
Epithelium, Pigmentation 1 (2%) 1 (2%) 1 (2%)
Lamina Propria, Inflammation, Chronic 1 (2%)
Mucosa, Ulcer 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Submucosa, Fatty Change 1 (2%)
Submucosa, Inflammation, Chronic Active 1 (2%)
Submucosa, Lamina Propria, Inflammation,
Chronic Active 36 (60%)
Intestine Large, Colon (59) (60) (59) (58)
Autolysis 3 (5%) 3 (5%) 2 (3%) 3 (5%)
Hyperplasia, Glandular 4 (7%)
Inflammation, Chronic Active 2 (3%)
Parasite Metazoan 13 (22%) 14 (23%) 14 (24%) 2 (3%)
Polyarteritis 1 (2%)
Ulcer 6 (10%)
Submucosa, Epithelium, Proliferation 1 (2%)
Intestine Large, Rectum (58) (59) (58) (58)
Autolysis 2 (3%) 2 (3%) 2 (3%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Parasite Metazoan 14 (24%) 5 (8%) 7 (12%)
Epithelium, Pigmentation 4 (7%)
Intestine Small, Duodenum (60) (60) (59) (60)
Autolysis 3 (5%) 3 (5%) 2 (3%) 4 (7%)
Intestine Small, Ileum (59) (60) (59) (60)
Autolysis 4 (7%) 4 (7%) 2 (3%) 3 (5%)
Fibrosis 2 (3%)
Hyperplasia, Glandular 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 5 (8%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Ulcer, Multiple 1 (2%)
Epithelium, Pigmentation 1 (2%) 4 (7%) 7 (12%)
Peyer's Patch, Hyperplasia 1 (2%)
Submucosa, Inflammation, Acute 1 (2%)
Intestine Small, Jejunum (60) (60) (59) (58)
Autolysis 5 (8%) 3 (5%) 2 (3%) 6 (10%)
Inflammation, Chronic 1 (2%) 1 (2%)
Epithelium, Pigmentation 1 (2%)
Muscularis, Hyperplasia 1 (2%) 1 (2%)
Liver (60) (57) (56) (60)
Angiectasis 5 (8%) 3 (5%) 5 (9%)
Autolysis 1 (2%) 1 (2%)
Basophilic Focus 9 (15%) 7 (12%) 10 (18%) 22 (37%)
Clear Cell Focus 3 (5%) 3 (5%) 3 (5%) 2 (3%)
Degeneration 7 (12%) 6 (11%) 17 (30%) 3 (5%)
Eosinophilic Focus 4 (7%) 6 (11%) 7 (13%) 3 (5%)
Fatty Change 9 (15%) 8 (14%) 6 (11%) 7 (12%)
Hepatodiaphragmatic Nodule 7 (12%) 6 (11%) 5 (9%) 11 (18%)
Hyperplasia 1 (2%) 4 (7%) 3 (5%) 3 (5%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 16 (27%) 13 (23%) 9 (16%) 19 (32%)
Mixed Cell Focus 1 (2%) 1 (2%) 5 (9%) 1 (2%)
Necrosis, Coagulative 1 (2%) 2 (3%)
Pigmentation 2 (3%) 2 (4%) 2 (4%)
Bile Duct, Hyperplasia 52 (87%) 48 (84%) 45 (80%) 43 (72%)
Mesentery (9) (3) (8) (7)
Fibrosis 7 (78%) 1 (33%) 6 (75%) 3 (43%)
Hemorrhage 1 (11%)
Inflammation, Chronic Active 3 (33%) 1 (33%) 5 (63%) 4 (57%)
Necrosis 1 (14%)
Necrosis, Liquifactive 5 (56%) 1 (33%) 6 (75%) 2 (29%)
Artery, Hyperplasia 1 (14%)
Artery, Inflammation, Chronic 2 (22%)
Perivascular, Inflammation, Chronic 1 (14%)
Pancreas (58) (50) (50) (59)
Atrophy 3 (5%) 3 (5%)
Autolysis 2 (4%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cytoplasmic Alteration 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 5 (9%) 5 (8%)
Inflammation, Chronic Active 16 (28%) 19 (38%) 10 (20%) 16 (27%)
Pigmentation 1 (2%)
Polyarteritis 2 (4%) 4 (8%)
Vacuolization Cytoplasmic 10 (17%) 7 (14%) 6 (12%) 6 (10%)
Acinus, Atrophy 22 (38%) 22 (44%) 24 (48%) 20 (34%)
Acinus, Hyperplasia 5 (9%) 2 (3%)
Salivary Glands (59) (49) (50) (59)
Duct, Submandibular Gland, Dilatation 1 (2%)
Duct, Submandibular Gland, Hyperplasia 7 (12%) 8 (16%) 3 (6%) 3 (5%)
Duct, Submandibular Gland, Inflammation,
Chronic Active 3 (5%) 1 (2%) 1 (2%)
Duct, Submandibular Gland, Metaplasia,
Squamous 11 (19%) 13 (27%) 5 (10%) 6 (10%)
Sublingual Gland, Inflammation, Chronic
Active 4 (7%) 1 (2%)
Submandibular Gland, Atrophy 1 (2%) 2 (3%)
Submandibular Gland, Fibrosis 1 (2%)
Submandibular Gland, Inflammation, Chronic 6 (10%) 3 (5%)
Submandibular Gland, Inflammation, Chronic
Active 18 (31%) 12 (24%) 11 (22%) 11 (19%)
Submandibular Gland, Necrosis, Coagulative 1 (2%)
Stomach (60) (60) (60) (60)
Lamina Propria, Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (59) (60) (53) (60)
Acanthosis 1 (2%)
Autolysis 1 (2%) 1 (2%)
Erosion 1 (2%)
Hyperkeratosis 4 (7%) 5 (8%) 2 (4%) 16 (27%)
Hyperplasia, Squamous 7 (12%) 5 (8%) 4 (8%) 18 (30%)
Inflammation, Chronic Active 4 (7%) 1 (2%) 6 (10%)
Ulcer 2 (3%) 3 (5%) 2 (4%) 5 (8%)
Ulcer, Multiple 1 (2%)
Muscularis, Mineralization 1 (2%)
Submucosa, Inflammation, Chronic Active 1 (2%)
Stomach, Glandular (60) (60) (60) (58)
Autolysis 2 (3%) 1 (2%) 2 (3%) 1 (2%)
Fibrosis 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 4 (7%) 1 (2%)
Metaplasia, Squamous 1 (2%) 1 (2%)
Necrosis, Coagulative 3 (5%) 2 (3%) 2 (3%)
Ulcer, Acute 1 (2%)
Epithelium, Pigmentation 1 (2%) 3 (5%) 5 (9%)
Mucosa, Dilatation 40 (67%) 45 (75%) 38 (63%) 36 (62%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Muscularis, Developmental Malformation 1 (2%)
Muscularis, Submucosa, Inflammation, Chronic
Active 1 (2%)
Submucosa, Inflammation, Chronic Active 1 (2%)
Tongue (1) (1) (3)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (50) (50) (60)
Abscess 1 (2%) 1 (2%)
Autolysis 1 (2%)
Cardiomyopathy 58 (97%) 48 (96%) 48 (96%) 57 (95%)
Congestion 1 (2%)
Mineralization 1 (2%)
Atrium, Thrombosis 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (50) (51) (60)
Capsule, Thrombosis 1 (2%)
Adrenal Gland, Cortex (60) (50) (50) (60)
Angiectasis 8 (13%) 6 (12%) 4 (8%) 9 (15%)
Autolysis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 8 (13%) 3 (6%) 3 (6%) 3 (5%)
Necrosis, Coagulative 1 (2%)
Necrosis, Coagulative, Focal 1 (2%)
Vacuolization Cytoplasmic 22 (37%) 16 (32%) 16 (32%) 22 (37%)
Adrenal Gland, Medulla (57) (50) (51) (59)
Angiectasis 1 (2%)
Autolysis 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 13 (23%) 8 (16%) 13 (25%) 15 (25%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Islets, Pancreatic (57) (50) (48) (58)
Hyperplasia 2 (4%) 2 (4%) 2 (4%)
Parathyroid Gland (56) (47) (49) (55)
Hyperplasia 2 (4%) 5 (11%) 4 (8%)
Pituitary Gland (60) (51) (50) (58)
Autolysis 1 (2%)
Pars Distalis, Angiectasis 2 (4%) 1 (2%)
Pars Distalis, Autolysis 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Cyst 4 (7%) 4 (8%) 2 (4%) 8 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia 25 (42%) 18 (35%) 17 (34%) 26 (45%)
Pars Intermedia, Angiectasis 1 (2%) 1 (2%) 1 (2%)
Pars Intermedia, Cyst 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (59) (50) (51) (60)
Autolysis 1 (2%) 1 (2%) 2 (3%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Pigmentation 3 (5%) 2 (4%) 1 (2%) 2 (3%)
C-Cell, Hyperplasia 18 (31%) 20 (40%) 18 (35%) 13 (22%)
Follicle, Pigmentation 1 (2%)
Follicular Cell, Cyst 1 (2%) 2 (4%)
Follicular Cell, Hyperplasia 1 (2%) 4 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (10) (2) (2) (9)
Atrophy 5 (50%) 8 (89%)
Epididymis (59) (50) (50) (59)
Autolysis 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 3 (5%) 3 (6%)
Penis (1)
Inflammation, Acute 1 (100%)
Preputial Gland (57) (51) (50) (60)
Autolysis 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic 3 (5%) 1 (2%) 1 (2%) 4 (7%)
Inflammation, Chronic Active 46 (81%) 46 (90%) 45 (90%) 44 (73%)
Duct, Dilatation 4 (8%) 2 (4%) 1 (2%)
Prostate (60) (50) (50) (60)
Autolysis 1 (2%) 1 (2%) 1 (2%)
Dilatation 1 (2%)
Fibrosis 1 (2%)
Inflammation, Acute 1 (2%) 3 (5%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 39 (65%) 26 (52%) 24 (48%) 41 (68%)
Epithelium, Hyperplasia 1 (2%) 3 (6%) 2 (4%)
Seminal Vesicle (60) (50) (51) (59)
Atrophy 33 (55%) 34 (68%) 32 (63%) 30 (51%)
Autolysis 1 (2%) 1 (2%)
Cyst 1 (2%)
Inflammation, Chronic Active 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Epithelium, Hyperplasia 1 (2%) 1 (2%)
Testes (60) (53) (54) (60)
Autolysis 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Polyarteritis 1 (2%)
Interstitial Cell, Hyperplasia 37 (62%) 27 (51%) 29 (54%) 39 (65%)
Seminiferous Tubule, Atrophy 33 (55%) 41 (77%) 38 (70%) 35 (58%)
Seminiferous Tubule, Mineralization 22 (37%) 20 (38%) 23 (43%) 18 (30%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (50) (49) (60)
Calvarium, Myelofibrosis 1 (2%)
Sternal, Autolysis 1 (2%) 1 (2%)
Sternal, Hypocellularity 1 (2%) 2 (3%)
Sternal, Myelofibrosis 1 (2%) 5 (10%) 1 (2%)
Lymph Node (59) (60) (60) (60)
Bronchial, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hemorrhage 1 (2%) 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Mediastinal, Pigmentation 1 (2%)
Pancreatic, Hemorrhage 2 (3%) 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Infiltration Cellular, Histiocyte 5 (8%) 2 (3%) 2 (3%) 1 (2%)
Pancreatic, Pigmentation 4 (7%)
Pancreatic, Sinus, Ectasia 1 (2%) 1 (2%)
Sinus, Ectasia 1 (2%)
Lymph Node, Mandibular (22) (15) (22) (17)
Autolysis 1 (5%)
Hemorrhage 3 (20%) 2 (9%) 2 (12%)
Hyperplasia, Lymphoid 2 (9%) 3 (20%) 1 (5%) 4 (24%)
Hyperplasia, Plasma Cell 4 (18%) 2 (13%) 2 (9%) 2 (12%)
Infiltration Cellular, Histiocyte 1 (5%)
Sinus, Ectasia 6 (27%) 4 (27%) 2 (9%)
Lymph Node, Mesenteric (59) (60) (60) (60)
Abscess 1 (2%)
Autolysis 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 2 (3%) 1 (2%)
Infiltration Cellular, Histiocyte 56 (95%) 58 (97%) 56 (93%) 43 (72%)
Inflammation, Chronic Active 10 (17%)
Pigmentation 9 (15%) 10 (17%) 9 (15%) 5 (8%)
Sinus, Ectasia 1 (2%) 9 (15%) 56 (93%)
Sinus, Ectasia, Multiple 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (60) (52) (50) (59)
Abscess 1 (2%)
Autolysis 1 (2%) 1 (2%) 1 (2%)
Bacterium 1 (2%)
Congestion 1 (2%)
Depletion Lymphoid 19 (32%) 17 (33%) 26 (52%) 13 (22%)
Fibrosis 8 (13%) 10 (19%) 12 (24%) 7 (12%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Necrosis, Coagulative 1 (2%)
Capsule, Inflammation, Chronic 1 (2%)
Thymus (50) (48) (45) (52)
Angiectasis 1 (2%)
Autolysis 1 (2%) 1 (2%)
Congestion 1 (2%)
Cyst 2 (4%) 1 (2%)
Depletion Lymphoid 1 (2%) 1 (2%) 6 (12%)
Ectopic Parathyroid Gland 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (39) (40) (50)
Galactocele 3 (6%) 3 (8%) 1 (3%) 1 (2%)
Hyperplasia 43 (91%) 36 (92%) 36 (90%) 46 (92%)
Inflammation, Chronic 1 (3%)
Pigmentation 1 (2%)
Skin (60) (51) (53) (60)
Abscess 1 (2%)
Acanthosis 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Acute, Necrotizing 1 (2%)
Foot, Acanthosis 1 (2%)
Foot, Hyperkeratosis 1 (2%)
Lip, Inflammation, Acute, Necrotizing 1 (2%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Necrosis, Liquifactive 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (50) (49) (60)
Cranium, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (50) (60)
Abscess 1 (2%)
Autolysis 1 (2%) 1 (2%) 1 (2%)
Gliosis 1 (2%)
Infarct 4 (8%) 2 (4%) 3 (5%)
Thrombosis 1 (2%)
Cerebellum, Infarct 2 (3%)
Cerebrum, Infarct 1 (2%) 1 (2%)
Pons, Infarct 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (57) (57) (60)
Autolysis 1 (2%) 1 (2%) 1 (2%)
Bronchiectasis 1 (2%)
Congestion 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Foreign Body 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 9 (15%) 8 (14%) 8 (14%) 12 (20%)
Inflammation, Chronic Active 5 (8%) 2 (4%) 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 5 (9%) 3 (5%)
Artery, Mineralization 27 (46%) 24 (42%) 22 (39%) 27 (45%)
Bronchiole, Epithelium, Hyperplasia 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Nose (60) (50) (50) (59)
Inflammation, Chronic Active 36 (60%) 31 (62%) 39 (78%) 31 (53%)
Metaplasia, Squamous 13 (22%) 10 (20%) 9 (18%) 9 (15%)
Glands, Hyperplasia 1 (2%)
Lumen, Foreign Body 3 (5%) 4 (8%) 2 (4%) 2 (3%)
Lumen, Inflammation, Acute 3 (5%) 1 (2%)
Mucosa, Inflammation, Chronic Active 1 (2%)
Mucosa, Ulcer 4 (8%) 4 (8%) 3 (5%)
Mucosa, Submucosa, Inflammation, Chronic
Active 2 (3%) 1 (2%)
Mucosa, Submucosa, Lumen, Inflammation,
Chronic Active 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 2 (3%) 4 (7%)
Nasolacrimal Duct, Metaplasia, Squamous 4 (7%)
Nasopharyngeal Duct, Inflammation, Acute 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Trachea (60) (50) (50) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Autolysis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (15) (5) (7) (9)
Cataract 2 (13%) 1 (14%) 1 (11%)
Phthisis Bulbi 1 (7%)
Anterior Chamber, Hemorrhage 1 (7%)
Cornea, Neovascularization 1 (11%)
Retina, Degeneration 2 (13%) 1 (14%)
Sclera, Metaplasia, Osseous 1 (7%)
Lacrimal Gland (1) (2)
Inflammation, Chronic 1 (50%)
Zymbal's Gland (1) (1)
Cyst 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (52) (50) (60)
Abscess 1 (2%) 1 (2%) 1 (2%)
Autolysis 2 (3%) 1 (2%) 2 (4%) 5 (8%)
Congestion 1 (2%)
Cyst 3 (5%) 4 (8%) 2 (4%) 1 (2%)
Glomerulosclerosis 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Nephropathy 58 (97%) 52 (100%) 48 (96%) 57 (95%)
Adventitia, Inflammation, Chronic Active 1 (2%)
Artery, Mineralization 1 (2%)
Proximal Convoluted Renal Tubule,
Inflammation, Acute 10 (17%) 5 (10%) 8 (16%) 6 (10%)
Proximal Convoluted Renal Tubule,
Pigmentation 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Inflammation, Acute 1 (2%)
Renal Tubule, Mineralization 1 (2%)
Transitional Epithelium, Hyperplasia 19 (32%) 16 (31%) 14 (28%) 5 (8%)
Urinary Bladder (59) (50) (50) (59)
Autolysis 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Calculus Gross Observation 1 (2%) 1 (2%)
Calculus Micro Observation Only 3 (5%) 2 (4%) 3 (5%)
Cyst 1 (2%)
Inflammation, Chronic 2 (3%)
Inflammation, Chronic Active 3 (5%) 2 (4%) 1 (2%)
Polyarteritis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05084-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TURMERIC OLEORESIN Date: 09/10/94
Route: DOSED FEED Time: 21:38:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 2,000PPM 10,000 50,000
MALE MALE PPM MALE PPM MALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Artery, Necrosis, Fibrinoid 1 (2%)
Subserosa, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
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