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https://ntp.niehs.nih.gov/go/3544

TDMS Study 05084-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         TURMERIC OLEORESIN


NTP Experiment-Test: 05084-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: DOSED FEED                                                                                                 Time: 21:38:50




       Facility:  TSI Mason Research

       Chemical CAS #:  458-37-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10            9                                     
  Early Deaths                                                                                                                      
    Dead                                               3            1            3            2                                     
    Moribund                                          14           22           19           15                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           26           28           34                                     
    Dead                                               1            1                                                               
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (60)         (60)         (60)         (60)                                   
      Autolysis                                        2 (3%)       2 (3%)       2 (3%)       3 (5%)                                
      Hyperplasia, Glandular                                                     1 (2%)      56 (93%)                               
      Parasite Metazoan                               22 (37%)     11 (18%)     11 (18%)      4 (7%)                                
      Ulcer                                                                                  26 (43%)                               
      Submucosa, Lamina Propria, Inflammation,                                                                                      
           Chronic Active                                                                    45 (75%)                               
   Intestine Large, Colon                             (60)         (60)         (60)         (59)                                   
      Autolysis                                        2 (3%)       2 (3%)       2 (3%)                                             
      Edema                                                                                   1 (2%)                                
      Hyperplasia, Glandular                                                                  1 (2%)                                
      Parasite Metazoan                               10 (17%)      9 (15%)     11 (18%)      1 (2%)                                
      Epithelium, Pigmentation                                                                8 (14%)                               
   Intestine Large, Rectum                            (60)         (59)         (59)         (60)                                   
      Autolysis                                        2 (3%)       2 (3%)       2 (3%)       1 (2%)                                
      Edema                                                                                   1 (2%)                                
      Parasite Metazoan                                8 (13%)      8 (14%)      3 (5%)       4 (7%)                                
      Epithelium, Pigmentation                                                                2 (3%)                                
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)                                   
      Autolysis                                        2 (3%)       2 (3%)       2 (3%)       2 (3%)                                
   Intestine Small, Ileum                             (60)         (60)         (59)         (60)                                   
      Autolysis                                        2 (3%)       2 (3%)       2 (3%)       3 (5%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Epithelium, Pigmentation                                                                9 (15%)                               
   Intestine Small, Jejunum                           (60)         (59)         (60)         (60)                                   
      Autolysis                                        2 (3%)       3 (5%)       2 (3%)       3 (5%)                                
   Liver                                              (60)         (52)         (54)         (60)                                   
      Angiectasis                                      1 (2%)       1 (2%)                    3 (5%)                                
      Autolysis                                        1 (2%)                                                                       
      Basophilic Focus                                32 (53%)     33 (63%)     30 (56%)     35 (58%)                               
      Clear Cell Focus                                 8 (13%)      7 (13%)      5 (9%)       6 (10%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Congestion                                                                 1 (2%)                                             
      Cytoplasmic Alteration                                        2 (4%)                    2 (3%)                                
      Degeneration                                                  1 (2%)       1 (2%)       2 (3%)                                
      Eosinophilic Focus                               2 (3%)       1 (2%)       3 (6%)       1 (2%)                                
      Fatty Change                                     9 (15%)     12 (23%)      6 (11%)      4 (7%)                                
      Fibrosis                                                      1 (2%)                                                          
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hepatodiaphragmatic Nodule                      10 (17%)      6 (12%)     10 (19%)      9 (15%)                               
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation                                                               1 (2%)                                             
      Inflammation, Chronic                            4 (7%)       1 (2%)       1 (2%)       4 (7%)                                
      Inflammation, Chronic Active                    23 (38%)     26 (50%)     19 (35%)     26 (43%)                               
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Mixed Cell Focus                                 5 (8%)       7 (13%)      1 (2%)                                             
      Necrosis, Coagulative                            7 (12%)      2 (4%)       4 (7%)       1 (2%)                                
      Pigmentation                                                  1 (2%)                                                          
      Bile Duct, Hyperplasia                          16 (27%)     19 (37%)     11 (20%)     14 (23%)                               
   Mesentery                                          (5)          (4)          (4)          (2)                                    
      Fibrosis                                         4 (80%)      2 (50%)      2 (50%)      1 (50%)                               
      Inflammation, Chronic                            1 (20%)                                                                      
      Inflammation, Chronic Active                     3 (60%)      2 (50%)      1 (25%)      2 (100%)                              
      Mineralization                                                             2 (50%)                                            
      Necrosis, Liquifactive                           1 (20%)      1 (25%)      3 (75%)      1 (50%)                               
   Pancreas                                           (60)         (50)         (50)         (59)                                   
      Atrophy                                                                                 1 (2%)                                
      Cytoplasmic Alteration                                        2 (4%)                                                          
      Ectopic Liver                                                 1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            3 (5%)                                 3 (5%)                                
      Inflammation, Chronic Active                    24 (40%)     22 (44%)     23 (46%)     17 (29%)                               
      Pigmentation                                                  1 (2%)                                                          
      Vacuolization Cytoplasmic                        4 (7%)       6 (12%)      4 (8%)       2 (3%)                                
      Acinus, Atrophy                                 24 (40%)     18 (36%)     25 (50%)     18 (31%)                               
      Acinus, Hyperplasia                              1 (2%)                                                                       
   Salivary Glands                                    (60)         (50)         (50)         (60)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Duct, Sublingual Gland, Hyperplasia                           1 (2%)                                                          
      Duct, Sublingual Gland, Metaplasia, Squamous                  2 (4%)                                                          
      Duct, Submandibular Gland, Hyperplasia           6 (10%)      5 (10%)      5 (10%)      6 (10%)                               
      Duct, Submandibular Gland, Inflammation,                                                                                      
           Chronic Active                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Duct, Submandibular Gland, Metaplasia,                                                                                        
          Squamous                                    12 (20%)     19 (38%)      8 (16%)     10 (17%)                               
      Parotid Gland, Atrophy                           1 (2%)       1 (2%)                    2 (3%)                                
      Parotid Gland, Inflammation, Chronic Active                                             1 (2%)                                
      Parotid Gland, Submandibular Gland,                                                                                           
          Inflammation, Chronic Active                 1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Sublingual Gland, Inflammation, Chronic          1 (2%)       1 (2%)                                                          
      Sublingual Gland, Inflammation, Chronic                                                                                       
          Active                                       2 (3%)       1 (2%)       3 (6%)                                             
      Sublingual Gland, Metaplasia, Squamous           1 (2%)                                                                       
      Submandibular Gland, Inflammation, Chronic       3 (5%)                                 1 (2%)                                
      Submandibular Gland, Inflammation, Chronic                                                                                    
          Active                                      16 (27%)     15 (30%)     11 (22%)     12 (20%)                               
   Stomach, Forestomach                               (60)         (60)         (59)         (60)                                   
      Acanthosis                                                                 1 (2%)                                             
      Foreign Body                                                                            1 (2%)                                
      Hyperkeratosis                                   2 (3%)       5 (8%)       6 (10%)      3 (5%)                                
      Hyperplasia, Squamous                            3 (5%)       6 (10%)      7 (12%)      4 (7%)                                
      Inflammation, Chronic Active                                  2 (3%)       1 (2%)       1 (2%)                                
      Ulcer                                            2 (3%)       5 (8%)       2 (3%)       1 (2%)                                
      Muscularis, Mineralization                                    1 (2%)                                                          
   Stomach, Glandular                                 (60)         (60)         (59)         (60)                                   
      Autolysis                                        1 (2%)       1 (2%)       1 (2%)                                             
      Fibrosis                                                      1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic Active                                               2 (3%)                                             
      Metaplasia, Squamous                             1 (2%)                                                                       
      Necrosis, Coagulative                                         1 (2%)       3 (5%)                                             
      Mucosa, Dilatation                              44 (73%)     48 (80%)     45 (76%)     44 (73%)                               
      Muscularis, Mineralization                                    1 (2%)                                                          
   Tongue                                                          (1)                       (1)                                    
      Hyperplasia, Squamous                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (50)         (60)                                   
      Cardiomyopathy                                  58 (97%)     48 (96%)     47 (94%)     58 (97%)                               
      Atrium, Thrombosis                                            2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (50)         (51)         (60)                                   
      Capsule, Fibrosis                                             1 (2%)                                                          
   Adrenal Gland, Cortex                              (60)         (50)         (51)         (59)                                   
      Angiectasis                                     44 (73%)     36 (72%)     37 (73%)     38 (64%)                               
      Autolysis                                                     1 (2%)                                                          
      Congestion                                                    2 (4%)                                                          
      Degeneration                                                               1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (3%)       1 (2%)                                                          
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                     12 (20%)     10 (20%)     11 (22%)      9 (15%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Necrosis, Coagulative                                                      1 (2%)                                             
      Vacuolization Cytoplasmic                       22 (37%)     14 (28%)     15 (29%)     11 (19%)                               
   Adrenal Gland, Medulla                             (60)         (49)         (50)         (59)                                   
      Autolysis                                                     1 (2%)                                                          
      Hyperplasia                                      3 (5%)       3 (6%)       2 (4%)       3 (5%)                                
      Necrosis, Coagulative                                                                   1 (2%)                                
   Islets, Pancreatic                                 (59)         (50)         (50)         (59)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (55)         (47)         (49)         (55)                                   
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (60)         (49)         (52)         (60)                                   
      Pars Distalis, Angiectasis                       6 (10%)      5 (10%)      6 (12%)      5 (8%)                                
      Pars Distalis, Cyst                             30 (50%)     19 (39%)     21 (40%)     41 (68%)                               
      Pars Distalis, Hyperplasia                      19 (32%)     21 (43%)     14 (27%)     19 (32%)                               
      Pars Distalis, Pigmentation                      1 (2%)                                                                       
      Pars Intermedia, Angiectasis                     1 (2%)       1 (2%)                    1 (2%)                                
      Pars Intermedia, Cyst                            1 (2%)                    1 (2%)       1 (2%)                                
      Pars Intermedia, Pigmentation                                              1 (2%)                                             
      Rathke's Cleft, Crystals                                                   1 (2%)                                             
   Thyroid Gland                                      (60)         (51)         (52)         (60)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Ultimobranchial Cyst                                                                    1 (2%)                                
      C-Cell, Hyperplasia                             33 (55%)     29 (57%)     24 (46%)     29 (48%)                               
      Follicular Cell, Cyst                                         1 (2%)       3 (6%)       1 (2%)                                
      Follicular Cell, Hyperplasia                                  2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (1)          (2)                                    
      Necrosis                                                                                1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (51)         (49)         (58)                                   
      Hyperplasia                                      7 (12%)      5 (10%)      5 (10%)      7 (12%)                               
      Inflammation, Chronic                            4 (7%)       3 (6%)                    6 (10%)                               
      Inflammation, Chronic Active                    32 (53%)     23 (45%)     26 (53%)     26 (45%)                               
      Duct, Dilatation                                 4 (7%)       4 (8%)       2 (4%)       3 (5%)                                
   Ovary                                              (60)         (51)         (51)         (60)                                   
      Cyst                                             2 (3%)       1 (2%)       6 (12%)      2 (3%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                                                                   1 (2%)                                
      Periovarian Tissue, Cyst                                      1 (2%)                                                          
   Uterus                                             (60)         (50)         (50)         (60)                                   
      Angiectasis                                                   1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Hydrometra                                       8 (13%)      5 (10%)      6 (12%)      7 (12%)                               
      Inflammation, Acute                              1 (2%)       3 (6%)       4 (8%)                                             
      Necrosis, Coagulative                                                      1 (2%)                                             
      Pigmentation                                     1 (2%)                                                                       
      Cervix, Cyst                                     1 (2%)       2 (4%)       6 (12%)                                            
      Endometrium, Cyst                                1 (2%)                                                                       
      Endometrium, Hyperplasia                         7 (12%)      5 (10%)      7 (14%)      9 (15%)                               
   Vagina                                             (1)          (2)                       (1)                                    
      Exudate                                                       2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (52)         (60)                                   
      Sternal, Autolysis                                                         1 (2%)       1 (2%)                                
      Sternal, Myelofibrosis                                        1 (2%)                                                          
   Lymph Node                                         (60)         (60)         (56)         (60)                                   
      Bronchial, Fibrosis                                           1 (2%)                                                          
      Bronchial, Hyperplasia, Lymphoid                              1 (2%)                                                          
      Mediastinal, Hemorrhage                          5 (8%)       4 (7%)                    1 (2%)                                
      Mediastinal, Hyperplasia, Lymphoid                            2 (3%)                                                          
      Mediastinal, Hyperplasia, Plasma Cell                         1 (2%)                                                          
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                   1 (2%)                                                                       
      Mediastinal, Pigmentation                        1 (2%)                                                                       
      Pancreatic, Infiltration Cellular, Histiocyte    1 (2%)       1 (2%)                    2 (3%)                                
      Pancreatic, Pigmentation                         1 (2%)                                 1 (2%)                                
   Lymph Node, Mandibular                             (4)          (9)          (6)          (7)                                    
      Hemorrhage                                       1 (25%)                   1 (17%)                                            
      Hyperplasia, Lymphoid                                         2 (22%)                                                         
      Hyperplasia, Plasma Cell                                                   2 (33%)                                            
      Sinus, Ectasia                                   1 (25%)      1 (11%)      1 (17%)      1 (14%)                               
   Lymph Node, Mesenteric                             (60)         (60)         (56)         (60)                                   
      Infiltration Cellular, Histiocyte               60 (100%)    57 (95%)     55 (98%)     55 (92%)                               
      Pigmentation                                     7 (12%)     10 (17%)      6 (11%)      8 (13%)                               
      Sinus, Ectasia                                                             1 (2%)      59 (98%)                               
   Spleen                                             (60)         (50)         (51)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Autolysis                                        1 (2%)                                                                       
      Cyst                                                                                    1 (2%)                                
      Depletion Lymphoid                              11 (18%)     14 (28%)      8 (16%)     11 (18%)                               
      Fibrosis                                         1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            2 (3%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                    1 (2%)       1 (2%)                                
   Thymus                                             (51)         (48)         (45)         (50)                                   
      Cyst                                             3 (6%)       1 (2%)       4 (9%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (49)         (49)         (59)                                   
      Galactocele                                      3 (5%)       1 (2%)       1 (2%)                                             
      Hyperplasia                                     57 (95%)     47 (96%)     47 (96%)     54 (92%)                               
   Skin                                               (58)         (50)         (51)         (59)                                   
      Abscess                                          1 (2%)                                                                       
      Acanthosis                                                    1 (2%)                                                          
      Hyperkeratosis                                                1 (2%)                                                          
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
      Foot, Acanthosis                                 2 (3%)                                                                       
      Foot, Hyperkeratosis                             2 (3%)                                                                       
      Foot, Inflammation, Chronic Active               1 (2%)                                                                       
      Subcutaneous Tissue, Cyst Epithelial                                                                                          
          Inclusion                                                 2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Chronic       2 (3%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (52)         (60)                                   
      Cranium, Hyperostosis                            1 (2%)       1 (2%)                    1 (2%)                                
      Cranium, Osteopetrosis                           1 (2%)       2 (3%)                    1 (2%)                                
      Sternum, Osteopetrosis                                        2 (3%)       1 (2%)       4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (50)         (60)                                   
      Gliosis                                          1 (2%)                                                                       
      Hydrocephalus                                    3 (5%)       3 (6%)       2 (4%)                                             
      Infarct                                                       1 (2%)       1 (2%)                                             
      Necrosis, Coagulative                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (52)         (52)         (60)                                   
      Abscess                                          1 (2%)                                                                       
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Infiltration Cellular, Histiocyte               19 (32%)     10 (19%)     12 (23%)     20 (33%)                               
      Inflammation, Chronic Active                                  3 (6%)                                                          
      Metaplasia, Osseous                              1 (2%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 4 (7%)       2 (4%)       1 (2%)       4 (7%)                                
      Alveolus, Mineralization                                                                1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Artery, Mineralization                          28 (47%)     19 (37%)     32 (62%)     32 (53%)                               
      Artery, Muscularis, Hyperplasia                  1 (2%)                                                                       
   Nose                                               (59)         (56)         (52)         (60)                                   
      Inflammation, Chronic Active                    28 (47%)     23 (41%)     23 (44%)     35 (58%)                               
      Metaplasia, Squamous                             2 (3%)       3 (5%)       3 (6%)       1 (2%)                                
      Lumen, Foreign Body                                           1 (2%)       2 (4%)                                             
      Lumen, Inflammation, Acute                       1 (2%)                                                                       
      Mucosa, Ulcer                                    1 (2%)       1 (2%)                                                          
      Mucosa, Submucosa, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)                                 1 (2%)                                
      Nasolacrimal Duct, Inflammation, Acute                                                  1 (2%)                                
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                                              2 (3%)                                
      Nasopharyngeal Duct, Inflammation, Acute         1 (2%)                                 1 (2%)                                
      Submucosa, Glands, Inflammation, Acute           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (9)          (10)         (7)          (13)                                   
      Cataract                                         1 (11%)      2 (20%)      3 (43%)      2 (15%)                               
      Phthisis Bulbi                                   2 (22%)                   1 (14%)      1 (8%)                                
      Cornea, Inflammation, Chronic Active             1 (11%)      1 (10%)                                                         
      Cornea, Neovascularization                       2 (22%)      1 (10%)                                                         
      Lens, Cataract                                                                          1 (8%)                                
      Retina, Degeneration                                          3 (30%)      4 (57%)      3 (23%)                               
   Lacrimal Gland                                                  (1)                                                              
      Inflammation, Chronic                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (51)         (49)         (60)                                   
      Autolysis                                        2 (3%)       1 (2%)       2 (4%)       1 (2%)                                
      Cyst                                                                       1 (2%)       1 (2%)                                
      Hydronephrosis                                   1 (2%)       1 (2%)                                                          
      Nephropathy                                     58 (97%)     49 (96%)     47 (96%)     55 (92%)                               
      Pelvis, Inflammation, Acute                                                1 (2%)                                             
      Proximal Convoluted Renal Tubule,                                                                                             
          Inflammation, Acute                                       1 (2%)                    1 (2%)                                
      Renal Tubule, Mineralization                     5 (8%)                    6 (12%)     14 (23%)                               
      Transitional Epithelium, Hyperplasia             7 (12%)      8 (16%)      6 (12%)     10 (17%)                               
      Transitional Epithelium, Mineralization                       1 (2%)       2 (4%)       2 (3%)                                
   Urinary Bladder                                    (60)         (48)         (49)         (60)                                   
      Autolysis                                                     1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     3 (5%)       1 (2%)       2 (4%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        2,000PPM     10,000       50,000                                    
                                                   FEMALE        FEMALE      PPM FEM      PPM FEM                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Subserosa, Mineralization                        1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10            9                                     
  Early Deaths                                                                                                                      
    Moribund                                          26           29           32           28                                     
    Dead                                               6            4            3            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                18           17           15           17                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (49)         (49)         (58)                                   
      Autolysis                                        1 (2%)                                                                       
      Hyperkeratosis                                                                          3 (5%)                                
      Ulcer                                            1 (2%)                                                                       
   Intestine Large, Cecum                             (60)         (59)         (60)         (60)                                   
      Autolysis                                        3 (5%)       3 (5%)       2 (3%)       3 (5%)                                
      Erosion                                                                                 1 (2%)                                
      Hyperplasia, Glandular                                        1 (2%)                   49 (82%)                               
      Inflammation, Chronic Active                                                            1 (2%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
      Parasite Metazoan                               17 (28%)     11 (19%)     16 (27%)      2 (3%)                                
      Polyarteritis                                                              1 (2%)                                             
      Ulcer                                                                      1 (2%)      32 (53%)                               
      Ulcer, Multiple                                                                         1 (2%)                                
      Epithelium, Pigmentation                                      1 (2%)       1 (2%)       1 (2%)                                
      Lamina Propria, Inflammation, Chronic                                                   1 (2%)                                
      Mucosa, Ulcer                                                                           1 (2%)                                
      Perivascular, Inflammation, Chronic Active       1 (2%)                                                                       
      Submucosa, Fatty Change                                                                 1 (2%)                                
      Submucosa, Inflammation, Chronic Active                       1 (2%)                                                          
      Submucosa, Lamina Propria, Inflammation,                                                                                      
           Chronic Active                                                                    36 (60%)                               
   Intestine Large, Colon                             (59)         (60)         (59)         (58)                                   
      Autolysis                                        3 (5%)       3 (5%)       2 (3%)       3 (5%)                                
      Hyperplasia, Glandular                                                                  4 (7%)                                
      Inflammation, Chronic Active                                                            2 (3%)                                
      Parasite Metazoan                               13 (22%)     14 (23%)     14 (24%)      2 (3%)                                
      Polyarteritis                                    1 (2%)                                                                       
      Ulcer                                                                                   6 (10%)                               
      Submucosa, Epithelium, Proliferation                                                    1 (2%)                                
   Intestine Large, Rectum                            (58)         (59)         (58)         (58)                                   
      Autolysis                                        2 (3%)       2 (3%)       2 (3%)       4 (7%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Parasite Metazoan                               14 (24%)      5 (8%)       7 (12%)                                            
      Epithelium, Pigmentation                                                                4 (7%)                                
   Intestine Small, Duodenum                          (60)         (60)         (59)         (60)                                   
      Autolysis                                        3 (5%)       3 (5%)       2 (3%)       4 (7%)                                
   Intestine Small, Ileum                             (59)         (60)         (59)         (60)                                   
      Autolysis                                        4 (7%)       4 (7%)       2 (3%)       3 (5%)                                
      Fibrosis                                                                   2 (3%)                                             
      Hyperplasia, Glandular                                                     1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       5 (8%)                    1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
      Ulcer, Multiple                                                            1 (2%)                                             
      Epithelium, Pigmentation                                      1 (2%)       4 (7%)       7 (12%)                               
      Peyer's Patch, Hyperplasia                                                 1 (2%)                                             
      Submucosa, Inflammation, Acute                                             1 (2%)                                             
   Intestine Small, Jejunum                           (60)         (60)         (59)         (58)                                   
      Autolysis                                        5 (8%)       3 (5%)       2 (3%)       6 (10%)                               
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Epithelium, Pigmentation                                                                1 (2%)                                
      Muscularis, Hyperplasia                                       1 (2%)       1 (2%)                                             
   Liver                                              (60)         (57)         (56)         (60)                                   
      Angiectasis                                      5 (8%)       3 (5%)       5 (9%)                                             
      Autolysis                                        1 (2%)                    1 (2%)                                             
      Basophilic Focus                                 9 (15%)      7 (12%)     10 (18%)     22 (37%)                               
      Clear Cell Focus                                 3 (5%)       3 (5%)       3 (5%)       2 (3%)                                
      Degeneration                                     7 (12%)      6 (11%)     17 (30%)      3 (5%)                                
      Eosinophilic Focus                               4 (7%)       6 (11%)      7 (13%)      3 (5%)                                
      Fatty Change                                     9 (15%)      8 (14%)      6 (11%)      7 (12%)                               
      Hepatodiaphragmatic Nodule                       7 (12%)      6 (11%)      5 (9%)      11 (18%)                               
      Hyperplasia                                      1 (2%)       4 (7%)       3 (5%)       3 (5%)                                
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic Active                    16 (27%)     13 (23%)      9 (16%)     19 (32%)                               
      Mixed Cell Focus                                 1 (2%)       1 (2%)       5 (9%)       1 (2%)                                
      Necrosis, Coagulative                                                      1 (2%)       2 (3%)                                
      Pigmentation                                     2 (3%)       2 (4%)       2 (4%)                                             
      Bile Duct, Hyperplasia                          52 (87%)     48 (84%)     45 (80%)     43 (72%)                               
   Mesentery                                          (9)          (3)          (8)          (7)                                    
      Fibrosis                                         7 (78%)      1 (33%)      6 (75%)      3 (43%)                               
      Hemorrhage                                       1 (11%)                                                                      
      Inflammation, Chronic Active                     3 (33%)      1 (33%)      5 (63%)      4 (57%)                               
      Necrosis                                                                                1 (14%)                               
      Necrosis, Liquifactive                           5 (56%)      1 (33%)      6 (75%)      2 (29%)                               
      Artery, Hyperplasia                                                                     1 (14%)                               
      Artery, Inflammation, Chronic                    2 (22%)                                                                      
      Perivascular, Inflammation, Chronic                                                     1 (14%)                               
   Pancreas                                           (58)         (50)         (50)         (59)                                   
      Atrophy                                          3 (5%)                                 3 (5%)                                
      Autolysis                                                     2 (4%)       2 (4%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cytoplasmic Alteration                           2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic                            5 (9%)                                 5 (8%)                                
      Inflammation, Chronic Active                    16 (28%)     19 (38%)     10 (20%)     16 (27%)                               
      Pigmentation                                                                            1 (2%)                                
      Polyarteritis                                                 2 (4%)       4 (8%)                                             
      Vacuolization Cytoplasmic                       10 (17%)      7 (14%)      6 (12%)      6 (10%)                               
      Acinus, Atrophy                                 22 (38%)     22 (44%)     24 (48%)     20 (34%)                               
      Acinus, Hyperplasia                              5 (9%)                                 2 (3%)                                
   Salivary Glands                                    (59)         (49)         (50)         (59)                                   
      Duct, Submandibular Gland, Dilatation                                                   1 (2%)                                
      Duct, Submandibular Gland, Hyperplasia           7 (12%)      8 (16%)      3 (6%)       3 (5%)                                
      Duct, Submandibular Gland, Inflammation,                                                                                      
           Chronic Active                              3 (5%)       1 (2%)       1 (2%)                                             
      Duct, Submandibular Gland, Metaplasia,                                                                                        
          Squamous                                    11 (19%)     13 (27%)      5 (10%)      6 (10%)                               
      Sublingual Gland, Inflammation, Chronic                                                                                       
          Active                                       4 (7%)                                 1 (2%)                                
      Submandibular Gland, Atrophy                     1 (2%)                                 2 (3%)                                
      Submandibular Gland, Fibrosis                                 1 (2%)                                                          
      Submandibular Gland, Inflammation, Chronic       6 (10%)                                3 (5%)                                
      Submandibular Gland, Inflammation, Chronic                                                                                    
          Active                                      18 (31%)     12 (24%)     11 (22%)     11 (19%)                               
      Submandibular Gland, Necrosis, Coagulative                                 1 (2%)                                             
   Stomach                                            (60)         (60)         (60)         (60)                                   
      Lamina Propria, Inflammation, Chronic Active                               1 (2%)                                             
   Stomach, Forestomach                               (59)         (60)         (53)         (60)                                   
      Acanthosis                                       1 (2%)                                                                       
      Autolysis                                        1 (2%)                    1 (2%)                                             
      Erosion                                                                                 1 (2%)                                
      Hyperkeratosis                                   4 (7%)       5 (8%)       2 (4%)      16 (27%)                               
      Hyperplasia, Squamous                            7 (12%)      5 (8%)       4 (8%)      18 (30%)                               
      Inflammation, Chronic Active                     4 (7%)                    1 (2%)       6 (10%)                               
      Ulcer                                            2 (3%)       3 (5%)       2 (4%)       5 (8%)                                
      Ulcer, Multiple                                                                         1 (2%)                                
      Muscularis, Mineralization                       1 (2%)                                                                       
      Submucosa, Inflammation, Chronic Active                                                 1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (58)                                   
      Autolysis                                        2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      Fibrosis                                         1 (2%)       1 (2%)       1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic Active                     4 (7%)                    1 (2%)                                             
      Metaplasia, Squamous                             1 (2%)                                 1 (2%)                                
      Necrosis, Coagulative                                         3 (5%)       2 (3%)       2 (3%)                                
      Ulcer, Acute                                     1 (2%)                                                                       
      Epithelium, Pigmentation                                      1 (2%)       3 (5%)       5 (9%)                                
      Mucosa, Dilatation                              40 (67%)     45 (75%)     38 (63%)     36 (62%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Muscularis, Developmental Malformation                                                  1 (2%)                                
      Muscularis, Submucosa, Inflammation, Chronic                                                                                  
          Active                                                                              1 (2%)                                
      Submucosa, Inflammation, Chronic Active                                                 1 (2%)                                
   Tongue                                                          (1)          (1)          (3)                                    
      Hemorrhage                                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (50)         (50)         (60)                                   
      Abscess                                          1 (2%)                                 1 (2%)                                
      Autolysis                                        1 (2%)                                                                       
      Cardiomyopathy                                  58 (97%)     48 (96%)     48 (96%)     57 (95%)                               
      Congestion                                                                              1 (2%)                                
      Mineralization                                   1 (2%)                                                                       
      Atrium, Thrombosis                               2 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (50)         (51)         (60)                                   
      Capsule, Thrombosis                                                        1 (2%)                                             
   Adrenal Gland, Cortex                              (60)         (50)         (50)         (60)                                   
      Angiectasis                                      8 (13%)      6 (12%)      4 (8%)       9 (15%)                               
      Autolysis                                        1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia                                      8 (13%)      3 (6%)       3 (6%)       3 (5%)                                
      Necrosis, Coagulative                                                                   1 (2%)                                
      Necrosis, Coagulative, Focal                                                            1 (2%)                                
      Vacuolization Cytoplasmic                       22 (37%)     16 (32%)     16 (32%)     22 (37%)                               
   Adrenal Gland, Medulla                             (57)         (50)         (51)         (59)                                   
      Angiectasis                                                                             1 (2%)                                
      Autolysis                                        1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia                                     13 (23%)      8 (16%)     13 (25%)     15 (25%)                               
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)                    1 (2%)                                
   Islets, Pancreatic                                 (57)         (50)         (48)         (58)                                   
      Hyperplasia                                      2 (4%)       2 (4%)       2 (4%)                                             
   Parathyroid Gland                                  (56)         (47)         (49)         (55)                                   
      Hyperplasia                                      2 (4%)       5 (11%)      4 (8%)                                             
   Pituitary Gland                                    (60)         (51)         (50)         (58)                                   
      Autolysis                                                                  1 (2%)                                             
      Pars Distalis, Angiectasis                                                 2 (4%)       1 (2%)                                
      Pars Distalis, Autolysis                         1 (2%)       1 (2%)                    1 (2%)                                
      Pars Distalis, Cyst                              4 (7%)       4 (8%)       2 (4%)       8 (14%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia                      25 (42%)     18 (35%)     17 (34%)     26 (45%)                               
      Pars Intermedia, Angiectasis                     1 (2%)       1 (2%)       1 (2%)                                             
      Pars Intermedia, Cyst                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (59)         (50)         (51)         (60)                                   
      Autolysis                                        1 (2%)                    1 (2%)       2 (3%)                                
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Pigmentation                                     3 (5%)       2 (4%)       1 (2%)       2 (3%)                                
      C-Cell, Hyperplasia                             18 (31%)     20 (40%)     18 (35%)     13 (22%)                               
      Follicle, Pigmentation                                                                  1 (2%)                                
      Follicular Cell, Cyst                                         1 (2%)       2 (4%)                                             
      Follicular Cell, Hyperplasia                                  1 (2%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (10)         (2)          (2)          (9)                                    
      Atrophy                                          5 (50%)                                8 (89%)                               
   Epididymis                                         (59)         (50)         (50)         (59)                                   
      Autolysis                                        1 (2%)                                                                       
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Chronic Active                     3 (5%)       3 (6%)                                                          
   Penis                                              (1)                                                                           
      Inflammation, Acute                              1 (100%)                                                                     
   Preputial Gland                                    (57)         (51)         (50)         (60)                                   
      Autolysis                                        1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                            3 (5%)       1 (2%)       1 (2%)       4 (7%)                                
      Inflammation, Chronic Active                    46 (81%)     46 (90%)     45 (90%)     44 (73%)                               
      Duct, Dilatation                                              4 (8%)       2 (4%)       1 (2%)                                
   Prostate                                           (60)         (50)         (50)         (60)                                   
      Autolysis                                        1 (2%)                    1 (2%)       1 (2%)                                
      Dilatation                                       1 (2%)                                                                       
      Fibrosis                                                                                1 (2%)                                
      Inflammation, Acute                              1 (2%)                                 3 (5%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Chronic Active                    39 (65%)     26 (52%)     24 (48%)     41 (68%)                               
      Epithelium, Hyperplasia                          1 (2%)       3 (6%)       2 (4%)                                             
   Seminal Vesicle                                    (60)         (50)         (51)         (59)                                   
      Atrophy                                         33 (55%)     34 (68%)     32 (63%)     30 (51%)                               
      Autolysis                                        1 (2%)                                 1 (2%)                                
      Cyst                                                                                    1 (2%)                                
      Inflammation, Chronic Active                     2 (3%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Epithelium, Hyperplasia                          1 (2%)                                 1 (2%)                                
   Testes                                             (60)         (53)         (54)         (60)                                   
      Autolysis                                        1 (2%)                    1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Polyarteritis                                                 1 (2%)                                                          
      Interstitial Cell, Hyperplasia                  37 (62%)     27 (51%)     29 (54%)     39 (65%)                               
      Seminiferous Tubule, Atrophy                    33 (55%)     41 (77%)     38 (70%)     35 (58%)                               
      Seminiferous Tubule, Mineralization             22 (37%)     20 (38%)     23 (43%)     18 (30%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (50)         (49)         (60)                                   
      Calvarium, Myelofibrosis                         1 (2%)                                                                       
      Sternal, Autolysis                               1 (2%)       1 (2%)                                                          
      Sternal, Hypocellularity                         1 (2%)                                 2 (3%)                                
      Sternal, Myelofibrosis                           1 (2%)       5 (10%)      1 (2%)                                             
   Lymph Node                                         (59)         (60)         (60)         (60)                                   
      Bronchial, Hyperplasia, Lymphoid                                           1 (2%)                                             
      Mediastinal, Hemorrhage                                                    1 (2%)       1 (2%)                                
      Mediastinal, Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                             1 (2%)                                             
      Mediastinal, Pigmentation                                                  1 (2%)                                             
      Pancreatic, Hemorrhage                           2 (3%)                                 1 (2%)                                
      Pancreatic, Hyperplasia, Lymphoid                             1 (2%)                                                          
      Pancreatic, Infiltration Cellular, Histiocyte    5 (8%)       2 (3%)       2 (3%)       1 (2%)                                
      Pancreatic, Pigmentation                         4 (7%)                                                                       
      Pancreatic, Sinus, Ectasia                       1 (2%)                    1 (2%)                                             
      Sinus, Ectasia                                                                          1 (2%)                                
   Lymph Node, Mandibular                             (22)         (15)         (22)         (17)                                   
      Autolysis                                                                  1 (5%)                                             
      Hemorrhage                                                    3 (20%)      2 (9%)       2 (12%)                               
      Hyperplasia, Lymphoid                            2 (9%)       3 (20%)      1 (5%)       4 (24%)                               
      Hyperplasia, Plasma Cell                         4 (18%)      2 (13%)      2 (9%)       2 (12%)                               
      Infiltration Cellular, Histiocyte                1 (5%)                                                                       
      Sinus, Ectasia                                   6 (27%)      4 (27%)      2 (9%)                                             
   Lymph Node, Mesenteric                             (59)         (60)         (60)         (60)                                   
      Abscess                                                                                 1 (2%)                                
      Autolysis                                                                  1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                                         3 (5%)       2 (3%)       1 (2%)                                
      Infiltration Cellular, Histiocyte               56 (95%)     58 (97%)     56 (93%)     43 (72%)                               
      Inflammation, Chronic Active                                                           10 (17%)                               
      Pigmentation                                     9 (15%)     10 (17%)      9 (15%)      5 (8%)                                
      Sinus, Ectasia                                                1 (2%)       9 (15%)     56 (93%)                               
      Sinus, Ectasia, Multiple                                                                1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (60)         (52)         (50)         (59)                                   
      Abscess                                                                                 1 (2%)                                
      Autolysis                                        1 (2%)       1 (2%)       1 (2%)                                             
      Bacterium                                                                               1 (2%)                                
      Congestion                                                    1 (2%)                                                          
      Depletion Lymphoid                              19 (32%)     17 (33%)     26 (52%)     13 (22%)                               
      Fibrosis                                         8 (13%)     10 (19%)     12 (24%)      7 (12%)                               
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)       1 (2%)                                
      Infiltration Cellular, Histiocyte                1 (2%)                    1 (2%)                                             
      Necrosis, Coagulative                            1 (2%)                                                                       
      Capsule, Inflammation, Chronic                   1 (2%)                                                                       
   Thymus                                             (50)         (48)         (45)         (52)                                   
      Angiectasis                                      1 (2%)                                                                       
      Autolysis                                                                  1 (2%)       1 (2%)                                
      Congestion                                                                              1 (2%)                                
      Cyst                                                                       2 (4%)       1 (2%)                                
      Depletion Lymphoid                               1 (2%)                    1 (2%)       6 (12%)                               
      Ectopic Parathyroid Gland                                     1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (39)         (40)         (50)                                   
      Galactocele                                      3 (6%)       3 (8%)       1 (3%)       1 (2%)                                
      Hyperplasia                                     43 (91%)     36 (92%)     36 (90%)     46 (92%)                               
      Inflammation, Chronic                                         1 (3%)                                                          
      Pigmentation                                                                            1 (2%)                                
   Skin                                               (60)         (51)         (53)         (60)                                   
      Abscess                                                                    1 (2%)                                             
      Acanthosis                                                    1 (2%)       1 (2%)                                             
      Hyperkeratosis                                                1 (2%)       1 (2%)                                             
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
      Inflammation, Acute, Necrotizing                              1 (2%)                                                          
      Foot, Acanthosis                                              1 (2%)                                                          
      Foot, Hyperkeratosis                                          1 (2%)                                                          
      Lip, Inflammation, Acute, Necrotizing            1 (2%)                                                                       
      Subcutaneous Tissue, Hemorrhage                                                         1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)                                                                       
      Subcutaneous Tissue, Necrosis, Liquifactive                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (50)         (49)         (60)                                   
      Cranium, Hyperostosis                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (50)         (60)                                   
      Abscess                                          1 (2%)                                                                       
      Autolysis                                        1 (2%)                    1 (2%)       1 (2%)                                
      Gliosis                                                       1 (2%)                                                          
      Infarct                                                       4 (8%)       2 (4%)       3 (5%)                                
      Thrombosis                                                                 1 (2%)                                             
      Cerebellum, Infarct                              2 (3%)                                                                       
      Cerebrum, Infarct                                1 (2%)                    1 (2%)                                             
      Pons, Infarct                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (57)         (57)         (60)                                   
      Autolysis                                        1 (2%)                    1 (2%)       1 (2%)                                
      Bronchiectasis                                                                          1 (2%)                                
      Congestion                                       1 (2%)       1 (2%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Foreign Body                                     2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Infiltration Cellular, Histiocyte                9 (15%)      8 (14%)      8 (14%)     12 (20%)                               
      Inflammation, Chronic Active                     5 (8%)       2 (4%)       1 (2%)       1 (2%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    5 (9%)       3 (5%)                                
      Artery, Mineralization                          27 (46%)     24 (42%)     22 (39%)     27 (45%)                               
      Bronchiole, Epithelium, Hyperplasia                                        1 (2%)                                             
      Perivascular, Inflammation, Chronic Active                                              1 (2%)                                
   Nose                                               (60)         (50)         (50)         (59)                                   
      Inflammation, Chronic Active                    36 (60%)     31 (62%)     39 (78%)     31 (53%)                               
      Metaplasia, Squamous                            13 (22%)     10 (20%)      9 (18%)      9 (15%)                               
      Glands, Hyperplasia                                                        1 (2%)                                             
      Lumen, Foreign Body                              3 (5%)       4 (8%)       2 (4%)       2 (3%)                                
      Lumen, Inflammation, Acute                       3 (5%)                    1 (2%)                                             
      Mucosa, Inflammation, Chronic Active                                                    1 (2%)                                
      Mucosa, Ulcer                                                 4 (8%)       4 (8%)       3 (5%)                                
      Mucosa, Submucosa, Inflammation, Chronic                                                                                      
          Active                                       2 (3%)                                 1 (2%)                                
      Mucosa, Submucosa, Lumen, Inflammation,                                                                                       
          Chronic Active                               1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       2 (3%)                                 4 (7%)                                
      Nasolacrimal Duct, Metaplasia, Squamous                                                 4 (7%)                                
      Nasopharyngeal Duct, Inflammation, Acute                                                1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous                               1 (2%)                                             
   Trachea                                            (60)         (50)         (50)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Autolysis                                        1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (15)         (5)          (7)          (9)                                    
      Cataract                                         2 (13%)                   1 (14%)      1 (11%)                               
      Phthisis Bulbi                                   1 (7%)                                                                       
      Anterior Chamber, Hemorrhage                     1 (7%)                                                                       
      Cornea, Neovascularization                                                              1 (11%)                               
      Retina, Degeneration                             2 (13%)                   1 (14%)                                            
      Sclera, Metaplasia, Osseous                      1 (7%)                                                                       
   Lacrimal Gland                                                               (1)          (2)                                    
      Inflammation, Chronic                                                                   1 (50%)                               
   Zymbal's Gland                                                               (1)          (1)                                    
      Cyst                                                                       1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (52)         (50)         (60)                                   
      Abscess                                          1 (2%)                    1 (2%)       1 (2%)                                
      Autolysis                                        2 (3%)       1 (2%)       2 (4%)       5 (8%)                                
      Congestion                                       1 (2%)                                                                       
      Cyst                                             3 (5%)       4 (8%)       2 (4%)       1 (2%)                                
      Glomerulosclerosis                               1 (2%)                                                                       
      Inflammation, Chronic                                                                   1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Nephropathy                                     58 (97%)     52 (100%)    48 (96%)     57 (95%)                               
      Adventitia, Inflammation, Chronic Active                                                1 (2%)                                
      Artery, Mineralization                           1 (2%)                                                                       
      Proximal Convoluted Renal Tubule,                                                                                             
          Inflammation, Acute                         10 (17%)      5 (10%)      8 (16%)      6 (10%)                               
      Proximal Convoluted Renal Tubule,                                                                                             
          Pigmentation                                                                        1 (2%)                                
      Renal Tubule, Hyperplasia                                                  1 (2%)                                             
      Renal Tubule, Inflammation, Acute                1 (2%)                                                                       
      Renal Tubule, Mineralization                     1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia            19 (32%)     16 (31%)     14 (28%)      5 (8%)                                
   Urinary Bladder                                    (59)         (50)         (50)         (59)                                   
      Autolysis                                        2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
      Calculus Gross Observation                                                 1 (2%)       1 (2%)                                
      Calculus Micro Observation Only                  3 (5%)                    2 (4%)       3 (5%)                                
      Cyst                                                                       1 (2%)                                             
      Inflammation, Chronic                                                                   2 (3%)                                
      Inflammation, Chronic Active                     3 (5%)                    2 (4%)       1 (2%)                                
      Polyarteritis                                    1 (2%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05084-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         TURMERIC OLEORESIN                                    Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 21:38:50  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        2,000PPM     10,000       50,000                                    
                                                   MALE          MALE        PPM MALE     PPM MALE                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Subserosa, Mineralization                                                               1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
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                             ----------              END OF REPORT             ----------         
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