TDMS Study 05084-01 Pathology Tables
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
Facility: TSI Mason Research
Chemical CAS #: 8024-37-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3| 3| 6| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5|
| 4| 4| 5| 0| 3| 4| 4| 4| 7| 7| 5| 5| 4| 5| 1| 4| 4| 5| 7| 7| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Parasite Metazoan | 1 1 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 2 1 1 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 2 2 2 1 1 |
Clear Cell Focus | 1 1 1 2 1 1 3 |
Eosinophilic Focus | 2 |
Fatty Change | 3 3 1 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 2 1 2 1 1 1 1 1 1|
Mixed Cell Focus | 2 2 |
Necrosis, Coagulative | 2 1 |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 3 |
Necrosis, Liquifactive | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1|
Vacuolization Cytoplasmic | 1 3 2 |
Acinus, Atrophy | 1 1 1 1 1 1 2 2 1 1 1 1 1|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3| 3| 6| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5|
| 4| 4| 5| 0| 3| 4| 4| 4| 7| 7| 5| 5| 4| 5| 1| 4| 4| 5| 7| 7| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Submandibular Gland, | |
Hyperplasia | 1 1 1 1 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 1 1 1 |
Parotid Gland, Atrophy | |
Parotid Gland, Submandibular Gland, | |
Inflammation, Chronic Active | |
Sublingual Gland, Inflammation, | |
Chronic | 1 |
Sublingual Gland, Inflammation, | |
Chronic Active | |
Sublingual Gland, Metaplasia, | |
Squamous | 1 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 1 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Metaplasia, Squamous | |
Mucosa, Dilatation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 1 2 2 1 1 2 2 2 2 1 1 2 2 1 2 2 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 2 1 2 1 1 2 1 1 1 1 2 1|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 2 2 1 2 2 3 |
Vacuolization Cytoplasmic | 1 2 2 1 2 1 3 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3| 3| 6| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5|
| 4| 4| 5| 0| 3| 4| 4| 4| 7| 7| 5| 5| 4| 5| 1| 4| 4| 5| 7| 7| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 2 |
Pars Distalis, Cyst | 2 2 2 2 2 2 1 2 2 1 1 1 1 2 2|
Pars Distalis, Hyperplasia | 1 1 2 1 2 2 2 2 2 1 4 |
Pars Distalis, Pigmentation | |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
C-Cell, Hyperplasia | 2 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
Inflammation, Chronic | 1|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 |
Hemorrhage | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 2 |
Inflammation, Acute | |
Pigmentation | 1 |
Cervix, Cyst | 4 |
Endometrium, Cyst | |
Endometrium, Hyperplasia | 1 1 2 3 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 1|
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3| 3| 6| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5|
| 4| 4| 5| 0| 3| 4| 4| 4| 7| 7| 5| 5| 4| 5| 1| 4| 4| 5| 7| 7| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Hemorrhage | |
Sinus, Ectasia | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | |
Depletion Lymphoid | 4 3 3 |
Fibrosis | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + + + M M + M + + + + + + M + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 3 2 |
Hyperplasia | 2 3 4 3 3 3 3 2 2 3 3 4 2 3 3 3 3 1 4 1 3 3 |
__________________________________________________________________________|
Skin | + + + + I + + + + + I + + + + + + + + + + + + + +|
Abscess | |
Foot, Acanthosis | 2 |
Foot, Hyperkeratosis | 3 |
Foot, Inflammation, Chronic Active | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | |
Cranium, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 5| 3| 3| 3| 5| 5| 3| 3| 3| 3| 6| 3| 3| 3| 5| 5| 3| 3| 3| 3| 5|
| 4| 4| 5| 0| 3| 4| 4| 4| 7| 7| 5| 5| 4| 5| 1| 4| 4| 5| 7| 7| 4| 4| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Artery, Muscularis, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 2 1 1 1 1 |
Metaplasia, Squamous | 2 |
Lumen, Inflammation, Acute | 2 |
Mucosa, Ulcer | |
Mucosa, Submucosa, Inflammation, | |
Chronic Active | 2 |
Nasopharyngeal Duct, Inflammation, | |
Acute | 1 |
Submucosa, Glands, Inflammation, | |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Cataract | |
Phthisis Bulbi | |
Cornea, Inflammation, Chronic Active | 2 |
Cornea, Neovascularization | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Hydronephrosis | |
Nephropathy | 1 2 2 2 1 2 2 2 1 2 3 1 2 2 1 1 1 1 2 1 1 2 1|
Renal Tubule, Mineralization | 1 1 |
Transitional Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Subserosa, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 5| 5| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 7| 4| 5| 5| 3| 3| 8| 5| 5| 3| 0| 5| 1| 5| 3| 3| 8| 4| 7| 3| 3| 3| 3| 9|
| 5| 6| 3| 7| 5| 4| 4| 0| 7| 5| 4| 3| 0| 7| 5| 4| 5| 1| 6| 4| 5| 5| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Autolysis | 3 |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 |
Clear Cell Focus | |
Eosinophilic Focus | 1 |
Fatty Change | 2 2 2 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 1 1 2 1 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1|
Mixed Cell Focus | 1 1 |
Necrosis, Coagulative | 1 1 1 |
Bile Duct, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Mesentery | + + +|
Fibrosis | 2 2|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2|
Necrosis, Liquifactive | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | |
Acinus, Atrophy | 1 1 4 1 2 2 2 1 1 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 5| 5| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 7| 4| 5| 5| 3| 3| 8| 5| 5| 3| 0| 5| 1| 5| 3| 3| 8| 4| 7| 3| 3| 3| 3| 9|
| 5| 6| 3| 7| 5| 4| 4| 0| 7| 5| 4| 3| 0| 7| 5| 4| 5| 1| 6| 4| 5| 5| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Submandibular Gland, | |
Hyperplasia | 1 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 1 |
Parotid Gland, Atrophy | |
Parotid Gland, Submandibular Gland, | |
Inflammation, Chronic Active | |
Sublingual Gland, Inflammation, | |
Chronic | |
Sublingual Gland, Inflammation, | |
Chronic Active | 1 |
Sublingual Gland, Metaplasia, | |
Squamous | |
Submandibular Gland, Inflammation, | |
Chronic | 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 |
Hyperplasia, Squamous | 3 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Metaplasia, Squamous | |
Mucosa, Dilatation | 1 2 2 1 1 2 1 1 1 1 1 1 1 2 2 1 1 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 2 1 1 2 2 2 2 1 1 2 3 1 1 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 1 2 1 1 2 1 1 1 1 1 1 1 2 1 2|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 1 |
Vacuolization Cytoplasmic | 2 1 1 3 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 5| 5| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 7| 4| 5| 5| 3| 3| 8| 5| 5| 3| 0| 5| 1| 5| 3| 3| 8| 4| 7| 3| 3| 3| 3| 9|
| 5| 6| 3| 7| 5| 4| 4| 0| 7| 5| 4| 3| 0| 7| 5| 4| 5| 1| 6| 4| 5| 5| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + + M + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | 1 1 2 3 2 1 2 2 2 1 2 2 2 |
Pars Distalis, Hyperplasia | 2 1 2 1 1 |
Pars Distalis, Pigmentation | 1 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 2 1 |
Duct, Dilatation | 2 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 2 2 1|
Inflammation, Acute | 2 |
Pigmentation | |
Cervix, Cyst | |
Endometrium, Cyst | 1 |
Endometrium, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 2 1 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 |
Mediastinal, Pigmentation | 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 5| 5| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 7| 4| 5| 5| 3| 3| 8| 5| 5| 3| 0| 5| 1| 5| 3| 3| 8| 4| 7| 3| 3| 3| 3| 9|
| 5| 6| 3| 7| 5| 4| 4| 0| 7| 5| 4| 3| 0| 7| 5| 4| 5| 1| 6| 4| 5| 5| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Hemorrhage | 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Autolysis | 3 |
Depletion Lymphoid | 2 2 4 1 1 |
Fibrosis | |
Hyperplasia, Lymphoid | 3 2 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + M + + + M|
Cyst | 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia | 3 2 3 1 2 3 3 3 2 2 3 2 2 2 2 2 3 2 3 1 2 2 2 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Foot, Acanthosis | 2 |
Foot, Hyperkeratosis | 2 |
Foot, Inflammation, Chronic Active | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 2 |
Cranium, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2|
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 3 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 5| 5| 4| 7| 7| 6| 6| 5| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 7| 4| 5| 5| 3| 3| 8| 5| 5| 3| 0| 5| 1| 5| 3| 3| 8| 4| 7| 3| 3| 3| 3| 9|
| 5| 6| 3| 7| 5| 4| 4| 0| 7| 5| 4| 3| 0| 7| 5| 4| 5| 1| 6| 4| 5| 5| 5| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1|
Artery, Muscularis, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 2 4 1 1 1 1 1 1 1|
Metaplasia, Squamous | 4 |
Lumen, Inflammation, Acute | |
Mucosa, Ulcer | 1 |
Mucosa, Submucosa, Inflammation, | |
Chronic Active | |
Nasopharyngeal Duct, Inflammation, | |
Acute | |
Submucosa, Glands, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | M + + + + |
Cataract | |
Phthisis Bulbi | 3 |
Cornea, Inflammation, Chronic Active | |
Cornea, Neovascularization | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hydronephrosis | 3 |
Nephropathy | 2 2 4 1 1 2 1 2 1 1 2 2 2 1 1 2 2 2 2 2 2 2 1 2 2|
Renal Tubule, Mineralization | 1 1 |
Transitional Epithelium, Hyperplasia | 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 |
Subserosa, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1| | |
| 4| 4| 5| 4| 8| 5| 7| 7| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.0|
Parasite Metazoan | 1 1 | 22 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 2 2.5|
Parasite Metazoan | 1 | 10 1.1|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.0|
Parasite Metazoan | | 8 1.1|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Autolysis | | 1 3.0|
Basophilic Focus | 1 1 2 1 1 1 | 32 1.1|
Clear Cell Focus | 1 | 8 1.4|
Eosinophilic Focus | | 2 1.5|
Fatty Change | 1 2 2 | 9 2.0|
Hepatodiaphragmatic Nodule | X X | 10 |
Inflammation, Chronic | | 4 1.3|
Inflammation, Chronic Active | 1 1 1 1 | 23 1.1|
Mixed Cell Focus | X | 5 1.5|
Necrosis, Coagulative | 1 1 | 7 1.1|
Bile Duct, Hyperplasia | 1 1 2 1 | 16 1.2|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fibrosis | 2 | 4 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 2 | 3 2.3|
Necrosis, Liquifactive | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 3 1.0|
Inflammation, Chronic Active | 1 1 1 2 2 | 24 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1| | |
| 4| 4| 5| 4| 8| 5| 7| 7| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Vacuolization Cytoplasmic | 1 | 4 1.8|
Acinus, Atrophy | 1 2 | 24 1.4|
Acinus, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Submandibular Gland, | | |
Hyperplasia | 2 | 6 1.2|
Duct, Submandibular Gland, | | |
Inflammation, Chronic Active | 1 | 1 1.0|
Duct, Submandibular Gland, | | |
Metaplasia, Squamous | 1 1 1 1 | 12 1.0|
Parotid Gland, Atrophy | 1 | 1 1.0|
Parotid Gland, Submandibular Gland, | | |
Inflammation, Chronic Active | 1 | 1 1.0|
Sublingual Gland, Inflammation, | | |
Chronic | | 1 1.0|
Sublingual Gland, Inflammation, | | |
Chronic Active | 1 | 2 1.0|
Sublingual Gland, Metaplasia, | | |
Squamous | | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | | 3 1.0|
Submandibular Gland, Inflammation, | | |
Chronic Active | 1 1 1 1 1 1 | 16 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 2 2.0|
Hyperplasia, Squamous | | 3 2.0|
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Metaplasia, Squamous | 2 | 1 2.0|
Mucosa, Dilatation | 2 2 2 1 1 2 2 1 1 | 44 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 1 2 2 1 1 1 | 58 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1| | |
| 4| 4| 5| 4| 8| 5| 7| 7| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | 2 2 1 2 1 1 1 2 | 44 1.3|
Hematopoietic Cell Proliferation | | 2 2.0|
Hyperplasia | 2 2 1 | 12 1.8|
Vacuolization Cytoplasmic | 1 | 22 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 3 3 | 6 2.3|
Pars Distalis, Cyst | 2 1 | 30 1.7|
Pars Distalis, Hyperplasia | 2 2 3 | 19 1.8|
Pars Distalis, Pigmentation | | 1 1.0|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 1.0|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 | 33 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 7 1.6|
Inflammation, Chronic | | 4 1.0|
Inflammation, Chronic Active | 1 2 1 1 1 1 1 | 32 1.2|
Duct, Dilatation | 2 | 4 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | | 2 3.5|
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | 3 | 8 2.1|
Inflammation, Acute | | 1 2.0|
Pigmentation | | 1 1.0|
Cervix, Cyst | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1| | |
| 4| 4| 5| 4| 8| 5| 7| 7| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Cyst | | 1 1.0|
Endometrium, Hyperplasia | | 7 1.4|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Hemorrhage | | 5 1.6|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Mediastinal, Pigmentation | | 1 1.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Pancreatic, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 4 |
Hemorrhage | | 1 3.0|
Sinus, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 | 60 1.0|
Pigmentation | | 7 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Autolysis | | 1 3.0|
Depletion Lymphoid | 1 1 3 | 11 2.3|
Fibrosis | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 2 2.5|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + I + + + | 51 |
Cyst | | 3 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Galactocele | | 3 2.7|
Hyperplasia | 2 3 2 3 2 4 2 2 2 3 | 57 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Abscess | | 1 4.0|
Foot, Acanthosis | | 2 2.0|
Foot, Hyperkeratosis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1| | |
| 4| 4| 5| 4| 8| 5| 7| 7| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Foot, Inflammation, Chronic Active | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Cranium, Hyperostosis | | 1 2.0|
Cranium, Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Gliosis | | 1 2.0|
Hydrocephalus | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Abscess | 4 | 1 4.0|
Infiltration Cellular, Histiocyte | 1 1 | 19 1.1|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 2.0|
Artery, Mineralization | 1 1 1 1 | 28 1.0|
Artery, Muscularis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | 1 2 1 | 28 1.2|
Metaplasia, Squamous | | 2 3.0|
Lumen, Inflammation, Acute | | 1 2.0|
Mucosa, Ulcer | | 1 1.0|
Mucosa, Submucosa, Inflammation, | | |
Chronic Active | | 1 2.0|
Nasopharyngeal Duct, Inflammation, | | |
Acute | | 1 1.0|
Submucosa, Glands, Inflammation, | | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 9 |
Cataract | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 3| 6| 3| 1| 0| 4| 1| | |
| 4| 4| 5| 4| 8| 5| 7| 7| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Phthisis Bulbi | 4 | 2 3.5|
Cornea, Inflammation, Chronic Active | | 1 2.0|
Cornea, Neovascularization | 1 | 2 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Autolysis | | 2 2.5|
Hydronephrosis | | 1 3.0|
Nephropathy | 2 2 2 2 2 2 2 3 1 2 | 58 1.7|
Renal Tubule, Mineralization | 1 | 5 1.0|
Transitional Epithelium, Hyperplasia | 1 | 7 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 3 1.0|
Subserosa, Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 5| 4| 3| 0| 5| 5| 5| 3| 3| 9| 5| 5| 3| 6| 2| 9| 6|
| 1| 1| 1| 1| 0| 3| 3| 2| 5| 4| 1| 0| 4| 7| 7| 1| 1| 4| 7| 5| 3| 7| 2| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Parasite Metazoan | 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Parasite Metazoan | 1 2 1 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + M + + + + + + + + + + + + +|
Autolysis | 2 2|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Clear Cell Focus | 1 2 |
Cytoplasmic Alteration | 2 |
Degeneration | |
Eosinophilic Focus | |
Fatty Change | 1 3 1 1 1 2 3|
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 |
Inflammation, Granulomatous | |
Mixed Cell Focus | 2 1 |
Necrosis, Coagulative | 2 |
Pigmentation | |
Bile Duct, Hyperplasia | 1 2 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 2 |
Inflammation, Chronic Active | 2 |
Necrosis, Liquifactive | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Ectopic Liver | X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 5| 4| 3| 0| 5| 5| 5| 3| 3| 9| 5| 5| 3| 6| 2| 9| 6|
| 1| 1| 1| 1| 0| 3| 3| 2| 5| 4| 1| 0| 4| 7| 7| 1| 1| 4| 7| 5| 3| 7| 2| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 |
Pigmentation | 1 |
Vacuolization Cytoplasmic | 2 2 2 |
Acinus, Atrophy | 2 1 1 1 1 1 1 1 4 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Duct, Sublingual Gland, Hyperplasia | |
Duct, Sublingual Gland, Metaplasia, | |
Squamous | |
Duct, Submandibular Gland, | |
Hyperplasia | |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | 1 |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 1 1 2 2 2 1 |
Parotid Gland, Atrophy | |
Sublingual Gland, Inflammation, | |
Chronic | |
Sublingual Gland, Inflammation, | |
Chronic Active | 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 1|
Inflammation, Chronic Active | |
Ulcer | 1|
Muscularis, Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Fibrosis | 1 |
Hyperplasia | |
Necrosis, Coagulative | 1 |
Mucosa, Dilatation | 1 2 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Muscularis, Mineralization | |
__________________________________________________________________________|
Tongue | + |
Hyperplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 2 1 1 1 2 1 1 1 1 2 1 2 1 1 1|
Atrium, Thrombosis | 1 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 5| 4| 3| 0| 5| 5| 5| 3| 3| 9| 5| 5| 3| 6| 2| 9| 6|
| 1| 1| 1| 1| 0| 3| 3| 2| 5| 4| 1| 0| 4| 7| 7| 1| 1| 4| 7| 5| 3| 7| 2| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Fibrosis | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 1 2 2 1 1 1 1 1 1 1 1|
Autolysis | |
Congestion | 2 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 1 1 1 2 |
Vacuolization Cytoplasmic | 1 2 1 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Cyst | 1 1 1 1 1 1 1 2 2 2 |
Pars Distalis, Hyperplasia | 1 3 1 2 2 1 2 2 2 2 1 |
Pars Intermedia, Angiectasis | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 |
Follicular Cell, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Periovarian Tissue, Cyst | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hydrometra | 1 |
Inflammation, Acute | 2 4 3 |
Cervix, Cyst | 4 4 |
Endometrium, Hyperplasia | 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 5| 4| 3| 0| 5| 5| 5| 3| 3| 9| 5| 5| 3| 6| 2| 9| 6|
| 1| 1| 1| 1| 0| 3| 3| 2| 5| 4| 1| 0| 4| 7| 7| 1| 1| 4| 7| 5| 3| 7| 2| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Exudate | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Fibrosis | |
Bronchial, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + +|
Hyperplasia, Lymphoid | 1 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 3 3 4 3 2 4 3 3|
Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + M + + + + M + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
Hyperplasia | 3 2 3 3 4 3 3 2 2 3 3 2 1 3 3 2 4 1 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 1 |
Hyperplasia, Basal Cell | 1 |
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 1 |
Cranium, Osteopetrosis | 2 |
Sternum, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 4| 4| 7| 6| 6| 5| 5|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 5| 4| 3| 0| 5| 5| 5| 3| 3| 9| 5| 5| 3| 6| 2| 9| 6|
| 1| 1| 1| 1| 0| 3| 3| 2| 5| 4| 1| 0| 4| 7| 7| 1| 1| 4| 7| 5| 3| 7| 2| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Infarct | 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 2 |
Artery, Mineralization | 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + M + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Chronic Active | 1 3 1 1 3 1 1 1 1|
Metaplasia, Squamous | 3 2 |
Lumen, Foreign Body | |
Mucosa, Ulcer | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + +|
Cataract | |
Cornea, Inflammation, Chronic Active | 3 |
Cornea, Neovascularization | 2 |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | + |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hydronephrosis | |
Nephropathy | 3 2 1 2 1 1 2 2 1 2 2 1 1 1 1 1 1 1 2 1 1|
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | |
Transitional Epithelium, Hyperplasia | 1 1 1 |
Transitional Epithelium, | |
Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 5| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 9| 5| 0| 0| 5| 1| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 0| 4| 5|
| 2| 2| 1| 1| 7| 2| 2| 2| 5| 5| 2| 2| 2| 0| 2| 2| 2| 2| 7| 5| 3| 2| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2,000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 2 2 1 1 |
Clear Cell Focus | 1 2 1 |
Cytoplasmic Alteration | |
Degeneration | 2 |
Eosinophilic Focus | X |
Fatty Change | 2 3 2 |
Fibrosis | |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Lymphoid | 4 |
Hyperplasia | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 1 1 1 1 2 1 1 1 1 1 1 2 |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | 2 1 2 2 |
Necrosis, Coagulative | |
Pigmentation | |
Bile Duct, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 2 |
Inflammation, Chronic Active | 2 |
Necrosis, Liquifactive | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Cytoplasmic Alteration | 1 |
Ectopic Liver | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 5| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 9| 5| 0| 0| 5| 1| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 0| 4| 5|
| 2| 2| 1| 1| 7| 2| 2| 2| 5| 5| 2| 2| 2| 0| 2| 2| 2| 2| 7| 5| 3| 2| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2,000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 1 1 2 1 2 1 1 1 1 1 1 |
Pigmentation | |
Vacuolization Cytoplasmic | 1 1 1 |
Acinus, Atrophy | 1 3 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
Duct, Sublingual Gland, Hyperplasia | 1 |
Duct, Sublingual Gland, Metaplasia, | |
Squamous | 1 |
Duct, Submandibular Gland, | |
Hyperplasia | 1 1 1 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 1 1 2 1 |
Parotid Gland, Atrophy | 1 |
Sublingual Gland, Inflammation, | |
Chronic | 1 |
Sublingual Gland, Inflammation, | |
Chronic Active | |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 1 1 1 |
Hyperplasia, Squamous | 2 2 2 1 |
Inflammation, Chronic Active | 1 |
Ulcer | 2 4 2 |
Muscularis, Mineralization | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | |
Hyperplasia | 2 |
Necrosis, Coagulative | |
Mucosa, Dilatation | 1 1 1 1 1 1 1 1 1 1 2 1 1 2 2 1 1 2 1 |
Muscularis, Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 1 1 2 1 1 2 1 2 2 2 2 2 2 2 1 1 1 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 5| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 9| 5| 0| 0| 5| 1| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 0| 4| 5|
| 2| 2| 1| 1| 7| 2| 2| 2| 5| 5| 2| 2| 2| 0| 2| 2| 2| 2| 7| 5| 3| 2| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2,000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
Capsule, Fibrosis | 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 2 1 1 2 2 1 1 1 2 1 1 1 1 |
Autolysis | 3 |
Congestion | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 2 2 |
Vacuolization Cytoplasmic | 1 1 2 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Autolysis | 3 |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + I + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + |
Pars Distalis, Angiectasis | 2 2 3 |
Pars Distalis, Cyst | 2 1 1 1 2 |
Pars Distalis, Hyperplasia | 2 2 2 1 1 1 2 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + |
Hyperplasia | 4 4 4 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 2 2 1 2 1 1 1 1 |
Duct, Dilatation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Hydrometra | 1 2 2 |
Inflammation, Acute | |
Cervix, Cyst | |
Endometrium, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 5| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 9| 5| 0| 0| 5| 1| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 0| 4| 5|
| 2| 2| 1| 1| 7| 2| 2| 2| 5| 5| 2| 2| 2| 0| 2| 2| 2| 2| 7| 5| 3| 2| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2,000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Exudate | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Fibrosis | 2 |
Bronchial, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hemorrhage | 2 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 2 |
Mediastinal, Hyperplasia, Plasma Cell| |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Hyperplasia, Lymphoid | |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 4 4 2 |
Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + |
Cyst | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + |
Galactocele | |
Hyperplasia | 3 3 2 2 2 2 2 2 2 3 2 3 2 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | X X |
Subcutaneous Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | |
Cranium, Osteopetrosis | 1 |
Sternum, Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 5| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 4| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 9| 5| 0| 0| 5| 1| 5| 3| 3| 3| 0| 5| 3| 3| 3| 5| 5| 3| 3| 0| 4| 5|
| 2| 2| 1| 1| 7| 2| 2| 2| 5| 5| 2| 2| 2| 0| 2| 2| 2| 2| 7| 5| 3| 2| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2,000 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Hydrocephalus | 1 1 1 |
Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation, Chronic Active | 3 |
Alveolar Epithelium, Hyperplasia | 3 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + M + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 |
Metaplasia, Squamous | |
Lumen, Foreign Body | |
Mucosa, Ulcer | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
Cataract | 3 |
Cornea, Inflammation, Chronic Active | |
Cornea, Neovascularization | |
Retina, Degeneration | 3 3 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Hydronephrosis | 4 |
Nephropathy | 2 3 2 1 1 4 3 1 1 2 2 2 1 2 3 1 1 2 2 |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | |
Transitional Epithelium, Hyperplasia | 1 1 |
Transitional Epithelium, | |
Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + |
Autolysis | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0| | |
| 4| 4| 3| 0| 8| 3| 2| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.0|
Parasite Metazoan | 1 1 | 11 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 2 2.5|
Parasite Metazoan | 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Autolysis | | 2 2.5|
Parasite Metazoan | 1 | 8 1.1|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | | 2 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Autolysis | | 3 2.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 52 |
Angiectasis | | 1 2.0|
Basophilic Focus | 1 1 1 1 1 1 | 33 1.1|
Clear Cell Focus | 1 2 | 7 1.4|
Cytoplasmic Alteration | 1 | 2 1.5|
Degeneration | | 1 2.0|
Eosinophilic Focus | | 1 |
Fatty Change | 2 3 | 12 2.0|
Fibrosis | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 6 |
Hyperplasia, Lymphoid | | 1 4.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 1 2 1 1 | 26 1.2|
Inflammation, Granulomatous | | 1 1.0|
Mixed Cell Focus | 1 | 7 1.6|
Necrosis, Coagulative | 2 | 2 2.0|
Pigmentation | 1 | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 | 19 1.1|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fibrosis | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0| | |
| 4| 4| 3| 0| 8| 3| 2| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 2 2.0|
Necrosis, Liquifactive | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Cytoplasmic Alteration | 1 | 2 1.0|
Ectopic Liver | | 1 |
Inflammation, Chronic Active | 1 1 1 | 22 1.1|
Pigmentation | | 1 1.0|
Vacuolization Cytoplasmic | | 6 1.5|
Acinus, Atrophy | 1 1 | 18 1.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
Duct, Sublingual Gland, Hyperplasia | | 1 1.0|
Duct, Sublingual Gland, Metaplasia, | | |
Squamous | 1 | 2 1.0|
Duct, Submandibular Gland, | | |
Hyperplasia | 1 1 | 5 1.0|
Duct, Submandibular Gland, | | |
Inflammation, Chronic Active | | 1 1.0|
Duct, Submandibular Gland, | | |
Metaplasia, Squamous | 1 2 1 1 1 | 19 1.3|
Parotid Gland, Atrophy | | 1 1.0|
Sublingual Gland, Inflammation, | | |
Chronic | | 1 1.0|
Sublingual Gland, Inflammation, | | |
Chronic Active | | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic Active | 1 1 1 1 | 15 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | 2 | 5 1.2|
Hyperplasia, Squamous | 2 | 6 1.7|
Inflammation, Chronic Active | 2 | 2 1.5|
Ulcer | 3 | 5 2.4|
Muscularis, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
Fibrosis | | 1 1.0|
Hyperplasia | | 1 2.0|
Necrosis, Coagulative | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0| | |
| 4| 4| 3| 0| 8| 3| 2| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Dilatation | 1 1 1 1 1 2 1 1 1 1 | 48 1.2|
Muscularis, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hyperplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Cardiomyopathy | 2 1 1 1 1 2 1 1 2 | 48 1.4|
Atrium, Thrombosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
Capsule, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Angiectasis | 1 1 1 2 1 1 1 1 | 36 1.3|
Autolysis | | 1 3.0|
Congestion | | 2 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 1 2 | 10 1.4|
Vacuolization Cytoplasmic | 1 2 | 14 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 49 |
Autolysis | | 1 3.0|
Hyperplasia | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 49 |
Pars Distalis, Angiectasis | 1 | 5 1.8|
Pars Distalis, Cyst | 1 2 1 2 | 19 1.4|
Pars Distalis, Hyperplasia | 2 2 1 | 21 1.7|
Pars Intermedia, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 51 |
C-Cell, Hyperplasia | 1 1 1 1 2 1 1 | 29 1.0|
Follicular Cell, Cyst | | 1 2.0|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0| | |
| 4| 4| 3| 0| 8| 3| 2| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 51 |
Hyperplasia | | 5 3.4|
Inflammation, Chronic | | 3 1.3|
Inflammation, Chronic Active | 1 1 1 1 1 3 1 | 23 1.2|
Duct, Dilatation | 2 2 3 | 4 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 51 |
Cyst | 4 | 1 4.0|
Periovarian Tissue, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Angiectasis | 2 | 1 2.0|
Hydrometra | 2 | 5 1.6|
Inflammation, Acute | | 3 3.0|
Cervix, Cyst | | 2 4.0|
Endometrium, Hyperplasia | 1 | 5 1.6|
__________________________________________________________________________|____________|
Vagina | | 2 |
Exudate | | 2 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Sternal, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Bronchial, Fibrosis | | 1 2.0|
Bronchial, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hemorrhage | 2 | 4 2.3|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 9 |
Hyperplasia, Lymphoid | 2 | 2 1.5|
Sinus, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 | 57 1.0|
Pigmentation | | 10 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Depletion Lymphoid | 3 4 | 14 3.1|
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 48 |
Cyst | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0| | |
| 4| 4| 3| 0| 8| 3| 2| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 49 |
Galactocele | | 1 |
Hyperplasia | 3 2 2 3 2 3 2 2 2 4 | 47 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 1.0|
Hyperplasia, Basal Cell | | 1 1.0|
Subcutaneous Tissue, Cyst Epithelial | | |
Inclusion | | 2 |
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Cranium, Hyperostosis | | 1 1.0|
Cranium, Osteopetrosis | | 2 1.5|
Sternum, Osteopetrosis | | 2 3.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Hydrocephalus | | 3 1.0|
Infarct | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 52 |
Infiltration Cellular, Histiocyte | 1 1 | 10 1.0|
Inflammation, Chronic Active | 1 1 | 3 1.7|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
Artery, Mineralization | 1 1 1 1 1 | 19 1.0|
__________________________________________________________________________|____________|
Nose | + + M + + + + + + + | 56 |
Inflammation, Chronic Active | 2 4 1 1 | 23 1.3|
Metaplasia, Squamous | 1 | 3 2.0|
Lumen, Foreign Body | 3 | 1 3.0|
Mucosa, Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| | |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 0| 8| 0| | |
| 4| 4| 3| 0| 8| 3| 2| 2| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
2,000 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 10 |
Cataract | 2 | 2 2.5|
Cornea, Inflammation, Chronic Active | | 1 3.0|
Cornea, Neovascularization | | 1 2.0|
Retina, Degeneration | 3 | 3 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 51 |
Autolysis | | 1 3.0|
Hydronephrosis | | 1 4.0|
Nephropathy | 1 2 1 2 1 2 1 4 1 | 49 1.7|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | 1 1 1 | 8 1.0|
Transitional Epithelium, | | |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 48 |
Autolysis | | 1 3.0|
Inflammation, Chronic Active | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 5| 1| 2| 2| 2| 2| 1| 2| 0| 8| 8| 7| 2| 2| 7| 5| 5| 3| 3| 2| 2| 4|
| 0| 0| 7| 5| 9| 9| 9| 9| 9| 4| 9| 0| 8| 0| 7| 9| 9| 6| 7| 5| 0| 0| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Glandular | |
Parasite Metazoan | 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Parasite Metazoan | 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 1 |
Clear Cell Focus | 1 1 1 |
Congestion | 2 |
Degeneration | |
Eosinophilic Focus | 1 |
Fatty Change | 1 3 3|
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 |
Inflammation | 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + |
Fibrosis | |
Inflammation, Chronic Active | |
Mineralization | |
Necrosis, Liquifactive | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Liver | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1|
Vacuolization Cytoplasmic | 1 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 5| 1| 2| 2| 2| 2| 1| 2| 0| 8| 8| 7| 2| 2| 7| 5| 5| 3| 3| 2| 2| 4|
| 0| 0| 7| 5| 9| 9| 9| 9| 9| 4| 9| 0| 8| 0| 7| 9| 9| 6| 7| 5| 0| 0| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Atrophy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Hyperplasia | 1 1 1 1 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 2 |
Sublingual Gland, Inflammation, | |
Chronic Active | 1 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2|
Hyperkeratosis | 1 1 2 2 |
Hyperplasia, Squamous | 1 2 3 3 2|
Inflammation, Chronic Active | 2 |
Ulcer | 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | 3|
Necrosis, Coagulative | |
Mucosa, Dilatation | 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 1 1 1 2 1 2 1 2 3 2 2 2 2 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 2 2 1 1 2 2 1 1 2 1 1 1 2 |
Degeneration | 2 |
Hyperplasia | 1 2 |
Necrosis, Coagulative | 2 |
Vacuolization Cytoplasmic | 1 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 5| 1| 2| 2| 2| 2| 1| 2| 0| 8| 8| 7| 2| 2| 7| 5| 5| 3| 3| 2| 2| 4|
| 0| 0| 7| 5| 9| 9| 9| 9| 9| 4| 9| 0| 8| 0| 7| 9| 9| 6| 7| 5| 0| 0| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | 1 2 1 1 1 2 1 1 2 1 2|
Pars Distalis, Hyperplasia | 1 2 2 2 1 2 |
Pars Intermedia, Cyst | |
Pars Intermedia, Pigmentation | |
Rathke's Cleft, Crystals | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 2 1 1 2 1 1 |
Follicular Cell, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation, Chronic Active | 1 2 2 1 1 1 4 1 1 1 1 2 1 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 |
Inflammation, Acute | 2 2 4 |
Necrosis, Coagulative | 3 |
Cervix, Cyst | 3 2 3 2 |
Endometrium, Hyperplasia | 2 1 4 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Autolysis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Hemorrhage | |
Hyperplasia, Plasma Cell | 2 |
Sinus, Ectasia | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Pigmentation | 1 1 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 3|
Fibrosis | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 5| 1| 2| 2| 2| 2| 1| 2| 0| 8| 8| 7| 2| 2| 7| 5| 5| 3| 3| 2| 2| 4|
| 0| 0| 7| 5| 9| 9| 9| 9| 9| 4| 9| 0| 8| 0| 7| 9| 9| 6| 7| 5| 0| 0| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | 2 1 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
Hyperplasia | 2 2 2 2 1 2 2 2 3 2 2 3 3 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Sternum, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 1 |
Infarct | |
Necrosis, Coagulative | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 |
Mineralization | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Metaplasia, Squamous | |
Lumen, Foreign Body | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Cataract | 4 4 |
Phthisis Bulbi | 3 |
Retina, Degeneration | 4 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + M + + + +|
Autolysis | 3 |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 7| 7| 7| 7| 4| 7| 7| 6| 6| 5| 7| 7| 5| 4| 4| 7| 7| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 5| 1| 2| 2| 2| 2| 1| 2| 0| 8| 8| 7| 2| 2| 7| 5| 5| 3| 3| 2| 2| 4|
| 0| 0| 7| 5| 9| 9| 9| 9| 9| 4| 9| 0| 8| 0| 7| 9| 9| 6| 7| 5| 0| 0| 9| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 2 2 2 1 2 2 1 2 2 2 2 1 2 2 4 1 1 1 2 1 1|
Pelvis, Inflammation, Acute | 2 |
Renal Tubule, Mineralization | 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 1 3 1 1 |
Transitional Epithelium, | |
Mineralization | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4|
DAY ON TEST | 3| 4| 5| 5| 5| 3| 3| 0| 8| 5| 3| 3| 3| 3| 5| 3| 3| 3| 0| 5| 3| 9| 2| 6| 5|
| 1| 7| 6| 5| 5| 0| 0| 8| 9| 5| 0| 0| 0| 0| 5| 1| 1| 0| 0| 5| 0| 1| 8| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Glandular | |
Parasite Metazoan | 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Parasite Metazoan | 1 2 2 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + M + + + + + + + + + +|
Autolysis | 2 |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Autolysis | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Clear Cell Focus | 1 |
Congestion | |
Degeneration | |
Eosinophilic Focus | X |
Fatty Change | 1 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 2 1 1 1 |
Inflammation | |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 |
Bile Duct, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 4 2 |
Inflammation, Chronic Active | 2 |
Mineralization | 1 1 |
Necrosis, Liquifactive | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Ectopic Liver | X |
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4|
DAY ON TEST | 3| 4| 5| 5| 5| 3| 3| 0| 8| 5| 3| 3| 3| 3| 5| 3| 3| 3| 0| 5| 3| 9| 2| 6| 5|
| 1| 7| 6| 5| 5| 0| 0| 8| 9| 5| 0| 0| 0| 0| 5| 1| 1| 0| 0| 5| 0| 1| 8| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Atrophy | 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Duct, Submandibular Gland, | |
Hyperplasia | 1 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 |
Sublingual Gland, Inflammation, | |
Chronic Active | 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 1 |
Hyperplasia, Squamous | 3 |
Inflammation, Chronic Active | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 4 |
Necrosis, Coagulative | 1 |
Mucosa, Dilatation | 2 1 1 2 1 2 1 1 2 2 1 1 1 2 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 1 1 2 2 2 1 1 2 1 2 2 1 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 1 2 2 1 1 2 1 1 1 1 2 1 1 |
Degeneration | |
Hyperplasia | 2 1 1 1 1 2 2 |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4|
DAY ON TEST | 3| 4| 5| 5| 5| 3| 3| 0| 8| 5| 3| 3| 3| 3| 5| 3| 3| 3| 0| 5| 3| 9| 2| 6| 5|
| 1| 7| 6| 5| 5| 0| 0| 8| 9| 5| 0| 0| 0| 0| 5| 1| 1| 0| 0| 5| 0| 1| 8| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cyst | 2 2 2 2 1 2 1 1 |
Pars Distalis, Hyperplasia | 2 1 1 2 2 2 |
Pars Intermedia, Cyst | 1 |
Pars Intermedia, Pigmentation | |
Rathke's Cleft, Crystals | 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 2 1 1 1 1 |
Follicular Cell, Cyst | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 1 1 |
Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 |
Duct, Dilatation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 2 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Hydrometra | 2 2 |
Inflammation, Acute | |
Necrosis, Coagulative | |
Cervix, Cyst | |
Endometrium, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Sternal, Autolysis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Hemorrhage | 1 |
Hyperplasia, Plasma Cell | 2 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Pigmentation | 1 1 1 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Depletion Lymphoid | 2 4 4 2 3 4 |
Fibrosis | 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4|
DAY ON TEST | 3| 4| 5| 5| 5| 3| 3| 0| 8| 5| 3| 3| 3| 3| 5| 3| 3| 3| 0| 5| 3| 9| 2| 6| 5|
| 1| 7| 6| 5| 5| 0| 0| 8| 9| 5| 0| 0| 0| 0| 5| 1| 1| 0| 0| 5| 0| 1| 8| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M |
Galactocele | |
Hyperplasia | 2 3 2 2 2 3 2 2 2 2 2 3 3 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + M |
Subcutaneous Tissue, Cyst Epithelial | |
Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
Sternum, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Hydrocephalus | 1 |
Infarct | 3 |
Necrosis, Coagulative | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 |
Mineralization | |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 4 4 |
Metaplasia, Squamous | 1 2 |
Lumen, Foreign Body | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + I + + + |
Cataract | 4 |
Phthisis Bulbi | |
Retina, Degeneration | 3 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 5| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 5| 5| 4| 4|
DAY ON TEST | 3| 4| 5| 5| 5| 3| 3| 0| 8| 5| 3| 3| 3| 3| 5| 3| 3| 3| 0| 5| 3| 9| 2| 6| 5|
| 1| 7| 6| 5| 5| 0| 0| 8| 9| 5| 0| 0| 0| 0| 5| 1| 1| 0| 0| 5| 0| 1| 8| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 1 1 1 1 1 3 2 1 2 1 1 2 1 2 1 2 1 1 2 |
Pelvis, Inflammation, Acute | |
Renal Tubule, Mineralization | 1 |
Transitional Epithelium, Hyperplasia | 1 |
Transitional Epithelium, | |
Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + + + + |
Autolysis | |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 4| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 5| 5| 5| 2| 2| 2| 0| 5| | |
| 0| 6| 6| 5| 5| 9| 9| 9| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
10,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
Hyperplasia, Glandular | 2 | 1 2.0|
Parasite Metazoan | 1 1 | 11 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 2 3.0|
Parasite Metazoan | 1 1 1 | 11 1.2|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Autolysis | | 2 3.0|
Parasite Metazoan | 1 | 3 1.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Autolysis | | 2 3.5|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 54 |
Basophilic Focus | 1 1 1 1 1 | 30 1.0|
Clear Cell Focus | 1 | 5 1.0|
Congestion | | 1 2.0|
Degeneration | 1 | 1 1.0|
Eosinophilic Focus | X | 3 1.0|
Fatty Change | 3 | 6 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 10 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 | 19 1.1|
Inflammation | | 1 1.0|
Mixed Cell Focus | 2 | 1 2.0|
Necrosis, Coagulative | 1 | 4 1.3|
Bile Duct, Hyperplasia | | 11 1.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fibrosis | | 2 3.0|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 4| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 5| 5| 5| 2| 2| 2| 0| 5| | |
| 0| 6| 6| 5| 5| 9| 9| 9| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
10,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Necrosis, Liquifactive | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Ectopic Liver | | 1 |
Inflammation, Chronic Active | 2 1 1 1 1 | 23 1.0|
Vacuolization Cytoplasmic | | 4 1.3|
Acinus, Atrophy | 2 2 1 1 | 25 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Duct, Submandibular Gland, | | |
Hyperplasia | | 5 1.0|
Duct, Submandibular Gland, | | |
Inflammation, Chronic Active | 1 | 1 1.0|
Duct, Submandibular Gland, | | |
Metaplasia, Squamous | 1 1 1 | 8 1.1|
Sublingual Gland, Inflammation, | | |
Chronic Active | | 3 1.0|
Submandibular Gland, Inflammation, | | |
Chronic Active | 1 | 11 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Acanthosis | | 1 2.0|
Hyperkeratosis | 2 | 6 1.5|
Hyperplasia, Squamous | 2 | 7 2.3|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Inflammation, Chronic Active | | 2 3.5|
Necrosis, Coagulative | 2 1 | 3 1.3|
Mucosa, Dilatation | 2 1 1 2 1 1 | 45 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy | 2 2 1 1 2 2 2 1 | 47 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 51 |
Angiectasis | 1 2 1 1 1 1 1 | 37 1.3|
Degeneration | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 4| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 5| 5| 5| 2| 2| 2| 0| 5| | |
| 0| 6| 6| 5| 5| 9| 9| 9| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
10,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 2 | 11 1.5|
Necrosis, Coagulative | | 1 2.0|
Vacuolization Cytoplasmic | 2 3 1 1 | 15 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 50 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 52 |
Pars Distalis, Angiectasis | 2 | 6 2.2|
Pars Distalis, Cyst | 1 2 | 21 1.5|
Pars Distalis, Hyperplasia | 1 2 | 14 1.6|
Pars Intermedia, Cyst | | 1 1.0|
Pars Intermedia, Pigmentation | 2 | 1 2.0|
Rathke's Cleft, Crystals | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 52 |
C-Cell, Hyperplasia | 2 1 1 1 | 24 1.2|
Follicular Cell, Cyst | | 3 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 49 |
Hyperplasia | | 5 1.8|
Inflammation, Chronic Active | 3 1 1 1 1 | 26 1.3|
Duct, Dilatation | | 2 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 51 |
Cyst | | 6 1.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 50 |
Hydrometra | 2 2 | 6 2.0|
Inflammation, Acute | 2 | 4 2.5|
Necrosis, Coagulative | | 1 3.0|
Cervix, Cyst | 2 2 | 6 2.3|
Endometrium, Hyperplasia | 2 | 7 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 52 |
Sternal, Autolysis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 4| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 5| 5| 5| 2| 2| 2| 0| 5| | |
| 0| 6| 6| 5| 5| 9| 9| 9| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
10,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 6 |
Hemorrhage | | 1 1.0|
Hyperplasia, Plasma Cell | | 2 2.0|
Sinus, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 56 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 | 55 1.0|
Pigmentation | 1 | 6 1.0|
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 51 |
Depletion Lymphoid | | 8 3.1|
Fibrosis | | 1 1.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M M + + + + I + | 45 |
Cyst | | 4 2.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 49 |
Galactocele | | 1 4.0|
Hyperplasia | 2 3 3 2 2 2 2 1 | 47 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 51 |
Subcutaneous Tissue, Cyst Epithelial | | |
Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 52 |
Sternum, Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Hydrocephalus | | 2 1.0|
Infarct | | 1 3.0|
Necrosis, Coagulative | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 52 |
Infiltration Cellular, Histiocyte | 1 1 | 12 1.0|
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 5| 4| 4| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 2| 5| 5| 5| 2| 2| 2| 0| 5| | |
| 0| 6| 6| 5| 5| 9| 9| 9| 8| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
10,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 1 | 32 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 52 |
Inflammation, Chronic Active | 1 1 1 4 | 23 1.4|
Metaplasia, Squamous | 2 | 3 1.7|
Lumen, Foreign Body | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 7 |
Cataract | | 3 4.0|
Phthisis Bulbi | | 1 3.0|
Retina, Degeneration | | 4 3.8|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 49 |
Autolysis | | 2 2.5|
Cyst | | 1 2.0|
Nephropathy | 2 2 1 2 2 2 1 | 47 1.6|
Pelvis, Inflammation, Acute | | 1 2.0|
Renal Tubule, Mineralization | | 6 1.0|
Transitional Epithelium, Hyperplasia | 1 | 6 1.3|
Transitional Epithelium, | | |
Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 49 |
Autolysis | | 1 3.0|
Inflammation, Chronic Active | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 1| 2| 2| 2| 9| 5|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 4| 7| 7| 7| 7| 7| 8| 7| 7| 8| 0| 9| 9| 9| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Hyperplasia, Glandular | 2 2 2 2 2 3 3 1 2 2 3 3 3 2 3 2 2 2 2 2 3 3 1|
Parasite Metazoan | 1 |
Ulcer | 1 3 2 1 2 1 1 1 3 1 2 3 2|
Submucosa, Lamina Propria, | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 3 1 2 2 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Glandular | |
Parasite Metazoan | |
Epithelium, Pigmentation | 1|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Edema | |
Parasite Metazoan | 1 1 |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Epithelium, Pigmentation | 1|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 |
Clear Cell Focus | 1 1 |
Cytoplasmic Alteration | |
Degeneration | 1 2 |
Eosinophilic Focus | 1 |
Fatty Change | 1 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic | 1|
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 1 1 1 2 |
Necrosis, Coagulative | 1 |
Bile Duct, Hyperplasia | 1 1 1 2 1|
__________________________________________________________________________|
Mesentery | + |
Fibrosis | 2 |
Inflammation, Chronic Active | 2 |
Necrosis, Liquifactive | 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 1| 2| 2| 2| 9| 5|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 4| 7| 7| 7| 7| 7| 8| 7| 7| 8| 0| 9| 9| 9| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 2 |
Acinus, Atrophy | 1 1 1 2 4 1 1 1 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Hyperplasia | 2 1 1 1 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | 1 |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 1 1 1 1 |
Parotid Gland, Atrophy | 2 |
Parotid Gland, Inflammation, Chronic | |
Active | 1 |
Submandibular Gland, Inflammation, | |
Chronic | |
Submandibular Gland, Inflammation, | |
Chronic Active | 2 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hyperkeratosis | |
Hyperplasia, Squamous | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Dilatation | 1 2 2 2 1 1 1 1 1 1 2 2 1 1 1 2 1 1 1 1 2 1 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 2 1 1 1 1 1 2 2 2 2 1 1 2 1 |
Hemorrhage | |
Hyperplasia | 1 1 1 1 |
Vacuolization Cytoplasmic | 1 2 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 1| 2| 2| 2| 9| 5|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 4| 7| 7| 7| 7| 7| 8| 7| 7| 8| 0| 9| 9| 9| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Cyst | 2 2 2 2 2 1 3 2 1 1 2 3 1 1 2 1 2 1 |
Pars Distalis, Hyperplasia | 2 1 2 2 1 2 3 3 2 2 2 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 1 1 2 2 1 2 |
Follicular Cell, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 1 1 1 1 3 1 1 1 1 1 1 2 1 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3|
Endometrium, Hyperplasia | 2 1 1 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Autolysis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 4 |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 1| 2| 2| 2| 9| 5|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 4| 7| 7| 7| 7| 7| 8| 7| 7| 8| 0| 9| 9| 9| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1|
Sinus, Ectasia | 3 3 4 3 3 2 4 3 2 3 2 3 3 4 3 3 4 3 4 2 2 3 3 3 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Depletion Lymphoid | 2 1 1 4 3 4 3 3 |
Fibrosis | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2 2 3 2 3 2 2 3 2 2 2 3 2 2 1 2 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | 2 |
Cranium, Osteopetrosis | 3 |
Sternum, Osteopetrosis | 4 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Mineralization | |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Metaplasia, Squamous | |
Mucosa, Submucosa, Inflammation, | |
Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 3 |
Nasopharyngeal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 7| 5| 5| 7| 7| 7| 5| 4|
DAY ON TEST | 2| 2| 2| 0| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 1| 2| 2| 2| 9| 5|
| 9| 9| 9| 8| 3| 9| 9| 9| 9| 4| 7| 7| 7| 7| 7| 8| 7| 7| 8| 0| 9| 9| 9| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 |
Phthisis Bulbi | 4 |
Lens, Cataract | |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cyst | |
Nephropathy | 2 2 1 2 2 1 2 2 2 2 2 2 2 1 1 2 2 1 1 1 2 2 1|
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 |
Renal Tubule, Mineralization | 1 1 |
Transitional Epithelium, Hyperplasia | 1 1 1 1 1 |
Transitional Epithelium, | |
Mineralization | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 2| 0| 1| 2| 2| 7| 5| 5| 2| 2| 2| 2| 5| 2| 2| 5| 5| 5|
| 9| 9| 9| 9| 7| 8| 8| 8| 0| 8| 7| 7| 3| 7| 5| 7| 7| 7| 1| 7| 7| 7| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Glandular | 3 3 3 3 3 1 1 2 2 2 2 2 2 2 1 2 3 1 3 3 1 1 2 2|
Parasite Metazoan | 1 1 |
Ulcer | 3 1 2 3 4 3 3 1 3 2|
Submucosa, Lamina Propria, | |
Inflammation, Chronic Active | 2 3 2 2 1 1 1 2 3 3 3 2 3 2 2 2 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Glandular | |
Parasite Metazoan | 1 |
Epithelium, Pigmentation | 1 1 1 1 2 1|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Edema | |
Parasite Metazoan | 1 1 |
Epithelium, Pigmentation | 1|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Epithelium, Pigmentation | 1 1 1 1 1 1|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 |
Clear Cell Focus | 1 1 1 |
Cytoplasmic Alteration | 2 2 |
Degeneration | |
Eosinophilic Focus | |
Fatty Change | 2 |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | |
Fibrosis | |
Inflammation, Chronic Active | |
Necrosis, Liquifactive | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 2| 0| 1| 2| 2| 7| 5| 5| 2| 2| 2| 2| 5| 2| 2| 5| 5| 5|
| 9| 9| 9| 9| 7| 8| 8| 8| 0| 8| 7| 7| 3| 7| 5| 7| 7| 7| 1| 7| 7| 7| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Inflammation, Chronic | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 |
Acinus, Atrophy | 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Hyperplasia | 1 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 2 |
Parotid Gland, Atrophy | 1 |
Parotid Gland, Inflammation, Chronic | |
Active | |
Submandibular Gland, Inflammation, | |
Chronic | 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Hyperkeratosis | 1 1 |
Hyperplasia, Squamous | 2 1 1 |
Inflammation, Chronic Active | 1 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Dilatation | 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 2 2 2 2 1 2 3 2 1 2 1 2 2 2 1 3 2 1 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 2 1 1 1 1 2 1 1 2 2 1 1 2 2 1 1|
Hemorrhage | |
Hyperplasia | 1 1 1 2 1 |
Vacuolization Cytoplasmic | 1 2 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 2| 0| 1| 2| 2| 7| 5| 5| 2| 2| 2| 2| 5| 2| 2| 5| 5| 5|
| 9| 9| 9| 9| 7| 8| 8| 8| 0| 8| 7| 7| 3| 7| 5| 7| 7| 7| 1| 7| 7| 7| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 2 |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 4 3 |
Pars Distalis, Cyst | 1 1 1 1 1 1 2 2 2 2 2 3 1 2 2 1 |
Pars Distalis, Hyperplasia | 2 2 3 3 1 2 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 2 3 1 1 1 1 2 2 2 1 1 |
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Necrosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
Inflammation, Chronic | 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 3 1 2 1 2 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 1 2 1 3 1 |
Endometrium, Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Autolysis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 2| 0| 1| 2| 2| 7| 5| 5| 2| 2| 2| 2| 5| 2| 2| 5| 5| 5|
| 9| 9| 9| 9| 7| 8| 8| 8| 0| 8| 7| 7| 3| 7| 5| 7| 7| 7| 1| 7| 7| 7| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 |
Pigmentation | 1 1 1 1 1 |
Sinus, Ectasia | 3 3 3 2 3 3 3 2 4 3 2 3 3 3 4 2 4 4 4 3 2 4 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Depletion Lymphoid | 4 2 |
Fibrosis | 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M M + + + + M + + + + + + M + +|
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 3 2 2 2 2 2 2 2 1 2 2 3 2 2 1 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | |
Cranium, Osteopetrosis | |
Sternum, Osteopetrosis | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 3 1 1 |
Alveolus, Mineralization | |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 4 1 1 1 1 |
Metaplasia, Squamous | |
Mucosa, Submucosa, Inflammation, | |
Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Acute | 3|
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
Nasopharyngeal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 2| 2| 2| 5| 2| 2| 2| 0| 1| 2| 2| 7| 5| 5| 2| 2| 2| 2| 5| 2| 2| 5| 5| 5|
| 9| 9| 9| 9| 7| 8| 8| 8| 0| 8| 7| 7| 3| 7| 5| 7| 7| 7| 1| 7| 7| 7| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
50,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + +|
Cataract | |
Phthisis Bulbi | |
Lens, Cataract | 2 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cyst | 2 |
Nephropathy | 2 2 1 2 1 3 2 2 2 3 1 1 1 2 2 2 2 2 2 2 2 1 2|
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | |
Renal Tubule, Mineralization | 1 1 1 1 1 1 1|
Transitional Epithelium, Hyperplasia | 1 1 1 |
Transitional Epithelium, | |
Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 3| 3| 7| 6| 4| 4| 4| | |
DAY ON TEST | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5| | |
| 8| 8| 2| 9| 1| 7| 1| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | 4 | 3 3.0|
Hyperplasia, Glandular | 1 2 2 3 3 3 1 3 3 | 56 2.2|
Parasite Metazoan | 1 | 4 1.0|
Ulcer | 3 3 3 | 26 2.2|
Submucosa, Lamina Propria, | | |
Inflammation, Chronic Active | 4 2 4 2 2 3 2 | 45 2.1|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + + | 59 |
Edema | 1 | 1 1.0|
Hyperplasia, Glandular | 2 | 1 2.0|
Parasite Metazoan | | 1 1.0|
Epithelium, Pigmentation | 1 | 8 1.1|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Autolysis | 4 | 1 4.0|
Edema | 2 | 1 2.0|
Parasite Metazoan | | 4 1.0|
Epithelium, Pigmentation | 1 | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | 4 | 3 3.7|
Epithelium, Pigmentation | 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | 4 | 3 3.7|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 1 2 | 3 1.7|
Basophilic Focus | 1 1 1 2 1 | 35 1.1|
Clear Cell Focus | 1 | 6 1.0|
Cytoplasmic Alteration | | 2 2.0|
Degeneration | | 2 1.5|
Eosinophilic Focus | | 1 1.0|
Fatty Change | 2 | 4 1.8|
Hepatodiaphragmatic Nodule | X X | 9 |
Inflammation, Chronic | | 4 1.0|
Inflammation, Chronic Active | 1 1 2 1 1 | 26 1.2|
Necrosis, Coagulative | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 3| 3| 7| 6| 4| 4| 4| | |
DAY ON TEST | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5| | |
| 8| 8| 2| 9| 1| 7| 1| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Bile Duct, Hyperplasia | 1 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Necrosis, Liquifactive | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + | 59 |
Atrophy | | 1 1.0|
Inflammation, Chronic | | 3 1.0|
Inflammation, Chronic Active | 1 1 | 17 1.0|
Vacuolization Cytoplasmic | | 2 1.5|
Acinus, Atrophy | 2 | 18 1.3|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Submandibular Gland, | | |
Hyperplasia | 1 | 6 1.2|
Duct, Submandibular Gland, | | |
Inflammation, Chronic Active | | 1 1.0|
Duct, Submandibular Gland, | | |
Metaplasia, Squamous | 1 | 10 1.1|
Parotid Gland, Atrophy | | 2 1.5|
Parotid Gland, Inflammation, Chronic | | |
Active | | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic | | 1 1.0|
Submandibular Gland, Inflammation, | | |
Chronic Active | | 12 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Foreign Body | | 1 1.0|
Hyperkeratosis | 2 | 3 1.3|
Hyperplasia, Squamous | 2 | 4 1.5|
Inflammation, Chronic Active | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Mucosa, Dilatation | 2 1 1 1 1 | 44 1.3|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 3| 3| 7| 6| 4| 4| 4| | |
DAY ON TEST | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5| | |
| 8| 8| 2| 9| 1| 7| 1| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 2 2 2 2 2 1 2 1 | 58 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + M + | 59 |
Angiectasis | 1 2 1 | 38 1.4|
Hemorrhage | 2 | 1 2.0|
Hyperplasia | | 9 1.1|
Vacuolization Cytoplasmic | 1 | 11 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + | 59 |
Hyperplasia | | 3 1.3|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | | 5 3.0|
Pars Distalis, Cyst | 2 3 1 2 3 2 1 | 41 1.7|
Pars Distalis, Hyperplasia | 2 2 | 19 2.1|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | 1 1 1 1 1 | 29 1.3|
Follicular Cell, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + | 58 |
Hyperplasia | 4 2 | 7 2.3|
Inflammation, Chronic | 1 1 | 6 1.0|
Inflammation, Chronic Active | 2 1 1 | 26 1.4|
Duct, Dilatation | 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | | 2 3.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 3| 3| 7| 6| 4| 4| 4| | |
DAY ON TEST | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5| | |
| 8| 8| 2| 9| 1| 7| 1| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hydrometra | 2 | 7 1.9|
Endometrium, Hyperplasia | 1 1 | 9 1.3|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Sternal, Autolysis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Hemorrhage | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 2 3.0|
Pancreatic, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 7 |
Sinus, Ectasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 | 55 1.0|
Pigmentation | 1 1 | 8 1.0|
Sinus, Ectasia | 3 3 2 2 2 2 2 4 2 2 | 59 2.9|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Depletion Lymphoid | 2 | 11 2.6|
Fibrosis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + I M M + + + M + + | 50 |
Cyst | | 3 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M | 59 |
Hyperplasia | 2 2 2 1 1 3 3 2 | 54 2.1|
__________________________________________________________________________|____________|
Skin | + + + + I + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Cranium, Hyperostosis | | 1 2.0|
Cranium, Osteopetrosis | | 1 3.0|
Sternum, Osteopetrosis | | 4 3.3|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 3| 3| 7| 6| 4| 4| 4| | |
DAY ON TEST | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5| | |
| 8| 8| 2| 9| 1| 7| 1| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Fibrosis | | 1 3.0|
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | 1 | 20 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 1.8|
Alveolus, Mineralization | 1 | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 1 | 32 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 4 1 | 35 1.2|
Metaplasia, Squamous | 2 | 1 2.0|
Mucosa, Submucosa, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 2 2.5|
Nasopharyngeal Duct, Inflammation, | | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 13 |
Cataract | 4 | 2 3.5|
Phthisis Bulbi | | 1 4.0|
Lens, Cataract | | 1 2.0|
Retina, Degeneration | 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Autolysis | 2 | 1 2.0|
Cyst | | 1 2.0|
Nephropathy | 2 2 2 2 2 2 1 1 1 | 55 1.7|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | | 1 1.0|
Renal Tubule, Mineralization | 1 1 1 1 1 | 14 1.0|
Transitional Epithelium, Hyperplasia | 1 1 | 10 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 3| 3| 7| 6| 4| 4| 4| | |
DAY ON TEST | 2| 2| 3| 5| 1| 2| 6| 9| 5| 5| | |
| 8| 8| 2| 9| 1| 7| 1| 3| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
PPM FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Transitional Epithelium, | | |
Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|
| 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + + + +|
Autolysis | |
Ulcer | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3|
Parasite Metazoan | 1 1 1 1 |
Perivascular, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3|
Parasite Metazoan | 1 3 3 1 2 2 |
Polyarteritis | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2|
Parasite Metazoan | 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + M|
Autolysis | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 2 4|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Autolysis | |
Basophilic Focus | X 1 X |
Clear Cell Focus | X 1 X |
Degeneration | 1 |
Eosinophilic Focus | X X |
Fatty Change | 2 1 2 3 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 3 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1 |
Mixed Cell Focus | |
Pigmentation | 1 |
Bile Duct, Hyperplasia | 1 2 2 1 2 1 1 2 1 1 2 2 1 2 1 1 1 2 1 1 1|
__________________________________________________________________________|
Mesentery | + + + |
Fibrosis | 1 3 |
Hemorrhage | 2 |
Inflammation, Chronic Active | |
Necrosis, Liquifactive | |
Artery, Inflammation, Chronic | 1 2 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|
| 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | |
Cytoplasmic Alteration | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 |
Vacuolization Cytoplasmic | 2 1 1 1 2 |
Acinus, Atrophy | 1 1 1 1 2 2 1 |
Acinus, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Hyperplasia | 2 1 1 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | 1 |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 2 1 2 1 2 |
Sublingual Gland, Inflammation, | |
Chronic Active | 1 1 1 |
Submandibular Gland, Atrophy | 2 |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 2 1 2 1 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Autolysis | |
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 1 3 |
Inflammation, Chronic Active | 1 1 4 |
Ulcer | 4 |
Muscularis, Mineralization | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2|
Fibrosis | 1 |
Inflammation, Chronic Active | 1 1 1 2 |
Metaplasia, Squamous | 2 |
Ulcer, Acute | 2 |
Mucosa, Dilatation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Autolysis | |
Cardiomyopathy | 2 2 2 2 2 3 2 2 2 2 2 2 2 3 2 3 2 2 2 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|
| 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 1 |
Atrium, Thrombosis | 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 1 |
Autolysis | |
Hyperplasia | 1 2 |
Vacuolization Cytoplasmic | 1 1 2 1 2 1 1 1 1 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Hyperplasia | 2 1 1 1 3 2 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Autolysis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 1 1 1 1 1 1 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 |
Pigmentation | 1 1 |
C-Cell, Hyperplasia | 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + + |
Atrophy | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|
| 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 2 1 2 2 1 2 2 1 2 2 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Dilatation | |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 1 4 1 3 3 2 1 1 1 2 1 2 1|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 2 2 3 2 2 2 3 2 2 3 2 |
Autolysis | |
Inflammation, Chronic Active | 2 1 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hemorrhage | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 2 4 4 4 4 4 4 1 4 4 4 4 4 |
Seminiferous Tubule, Mineralization | 1 1 1 1 1 4 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | 4 |
Sternal, Autolysis | |
Sternal, Hypocellularity | |
Sternal, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Hemorrhage | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 1 |
Pancreatic, Pigmentation | 1 |
Pancreatic, Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 2 |
Infiltration Cellular, Histiocyte | 1 |
Sinus, Ectasia | 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Depletion Lymphoid | 3 2 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|
| 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 2 1 |
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Histiocyte | 2 |
Necrosis, Coagulative | |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + I + + + M + M + + + M + M + +|
Angiectasis | |
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M M + + M + M|
Galactocele | |
Hyperplasia | 1 1 1 1 1 2 1 2 2 2 2 2 1 2 2 1 2 1 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lip, Inflammation, Acute, Necrotizing| |
Subcutaneous Tissue, Inflammation, | |
Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 1 |
Autolysis | |
Cerebellum, Infarct | 3 |
Cerebrum, Infarct | |
Pons, Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | |
Foreign Body | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Chronic Active | 2 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 2 2 2 4 2 4 2 3 1 1 2 1 3 |
Metaplasia, Squamous | 2 2 3 2 2 2 2 2 |
Lumen, Foreign Body | |
Lumen, Inflammation, Acute | 2 2 2 |
Mucosa, Submucosa, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 6| 5| 4| 4|
DAY ON TEST | 1| 7| 6| 5| 5| 3| 3| 3| 4| 5| 3| 3| 2| 1| 6| 3| 3| 3| 5| 3| 3| 9| 2| 5| 0|
| 8| 1| 5| 9| 9| 5| 2| 2| 3| 6| 5| 5| 2| 1| 2| 5| 5| 2| 3| 5| 5| 5| 1| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Chronic Active | 2 2 |
Mucosa, Submucosa, Lumen, | |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
Cataract | 3 |
Phthisis Bulbi | |
Anterior Chamber, Hemorrhage | 4 |
Retina, Degeneration | 4 |
Sclera, Metaplasia, Osseous | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Autolysis | 2|
Congestion | 1 |
Cyst | 2 2 |
Glomerulosclerosis | 4 |
Nephropathy | 3 4 1 2 2 3 3 3 2 2 2 3 3 2 2 3 2 2 1 2 3 3 2 2|
Artery, Mineralization | 1 |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 1 1 1 |
Renal Tubule, Inflammation, Acute | |
Renal Tubule, Mineralization | 2 |
Transitional Epithelium, Hyperplasia | 2 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2|
Calculus Micro Observation Only | 3 |
Inflammation, Chronic Active | 1 1 |
Polyarteritis | |
Artery, Necrosis, Fibrinoid | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|
| 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Ulcer | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 4 |
Parasite Metazoan | 1 1 1 1 1 1 1 1 1|
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 4 |
Parasite Metazoan | 1 1 2 1|
Polyarteritis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + I + + + + + + + + + + + + + +|
Autolysis | 4 |
Parasite Metazoan | 1 1 2 1|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 2 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 |
Autolysis | 2 |
Basophilic Focus | X X X X X |
Clear Cell Focus | |
Degeneration | 2 1 1 |
Eosinophilic Focus | X |
Fatty Change | 2 1 2 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1|
Mixed Cell Focus | |
Pigmentation | 1 |
Bile Duct, Hyperplasia | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fibrosis | 3 1 3 2 |
Hemorrhage | |
Inflammation, Chronic Active | 2 3 2 |
Necrosis, Liquifactive | 2 2 2 2 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|
| 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +|
Atrophy | 1 1 |
Cytoplasmic Alteration | |
Inflammation, Chronic | 1 1 1|
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 |
Vacuolization Cytoplasmic | 1 2 2 2 |
Acinus, Atrophy | 2 1 1 1 1 2 1 1 1 1 1 |
Acinus, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Hyperplasia | 1 1 1 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | 1 |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 1 |
Sublingual Gland, Inflammation, | |
Chronic Active | |
Submandibular Gland, Atrophy | |
Submandibular Gland, Inflammation, | |
Chronic | 1 1 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Autolysis | 4 |
Hyperkeratosis | 2 |
Hyperplasia, Squamous | 1 2 4 |
Inflammation, Chronic Active | 2 |
Ulcer | 2 |
Muscularis, Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Fibrosis | |
Inflammation, Chronic Active | |
Metaplasia, Squamous | |
Ulcer, Acute | |
Mucosa, Dilatation | 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Autolysis | 2 |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 1 2 2 1 2 1 2 2|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|
| 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 |
Autolysis | 4 |
Hyperplasia | 2 2 1 1|
Vacuolization Cytoplasmic | 1 1 2 1 1 1 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia | 1 2 1 1 1 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + A + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + M + M + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Autolysis | 3 |
Pars Distalis, Cyst | 2 2 1 |
Pars Distalis, Hyperplasia | 2 2 1 3 1 2 1 1 1 1 1|
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic Active | |
Pigmentation | 1 |
C-Cell, Hyperplasia | 1 2 2 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + |
Atrophy | 2 2 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|
| 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic | 1 1|
Inflammation, Chronic Active | 1 2 1 2 2 1 1 4 2 1 1 1 1 3 1 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Dilatation | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 3 3 2 2 3 1 1 1 1 2 1 4 4 1 2|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 2 2 2 2 2 2 3 2 2 |
Autolysis | 2 |
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hemorrhage | 1 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 4 4 1 2 2 3 4 4 2 4 4 4 |
Seminiferous Tubule, Mineralization | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calvarium, Myelofibrosis | |
Sternal, Autolysis | 4 |
Sternal, Hypocellularity | |
Sternal, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pancreatic, Hemorrhage | 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 1|
Pancreatic, Pigmentation | 1 1|
Pancreatic, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 3 |
Infiltration Cellular, Histiocyte | |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 2 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Depletion Lymphoid | 2 3 3 3 4 2 4 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|
| 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 1 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
Necrosis, Coagulative | 2 |
Capsule, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + I + + + + + + M + +|
Angiectasis | 2 |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + M + + + + M M + M + + + M + + M + +|
Galactocele | 3 |
Hyperplasia | 3 1 3 1 2 3 2 2 2 1 2 3 2 1 1 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lip, Inflammation, Acute, Necrotizing| 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Autolysis | 2 |
Cerebellum, Infarct | 2 |
Cerebrum, Infarct | 2 |
Pons, Infarct | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Congestion | 2 |
Foreign Body | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1|
Inflammation, Chronic Active | 4 2 |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 3 4 1 3 1 1 1 2 1 2 4 1 1 |
Metaplasia, Squamous | 1 2 1 |
Lumen, Foreign Body | 2 2 |
Lumen, Inflammation, Acute | |
Mucosa, Submucosa, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 6| 6| 6| 5| 5| 7| 7| 6| 5| 4| 4| 7| 5| 5| 4| 7| 7| 5| 4| 4|
DAY ON TEST | 1| 9| 3| 4| 5| 3| 7| 0| 6| 2| 3| 3| 5| 8| 5| 9| 3| 2| 0| 5| 3| 3| 3| 5| 5|
| 5| 6| 4| 3| 6| 3| 6| 9| 7| 9| 2| 2| 5| 9| 6| 4| 2| 1| 5| 9| 2| 2| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Chronic Active | |
Mucosa, Submucosa, Lumen, | |
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + |
Cataract | 4 |
Phthisis Bulbi | 3 |
Anterior Chamber, Hemorrhage | |
Retina, Degeneration | 4 |
Sclera, Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Autolysis | 4 |
Congestion | |
Cyst | 1 |
Glomerulosclerosis | |
Nephropathy | 2 4 2 2 2 2 3 2 3 2 3 4 3 3 1 3 2 2 2 3 3 2 2 2|
Artery, Mineralization | |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 1 |
Renal Tubule, Inflammation, Acute | 1 |
Renal Tubule, Mineralization | |
Transitional Epithelium, Hyperplasia | 2 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
Autolysis | 3 |
Calculus Micro Observation Only | 2 |
Inflammation, Chronic Active | 1 |
Polyarteritis | 2 |
Artery, Necrosis, Fibrinoid | 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 7| 7| 6| 4| | |
DAY ON TEST | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5| | |
| 2| 5| 7| 4| 3| 5| 5| 5| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 3 3.0|
Parasite Metazoan | 1 1 1 1 | 17 1.0|
Perivascular, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Autolysis | | 3 2.7|
Parasite Metazoan | 2 1 1 | 13 1.6|
Polyarteritis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Autolysis | | 2 3.0|
Parasite Metazoan | 1 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 3 3.3|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Autolysis | 4 | 4 3.3|
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 5 3.4|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 5 1.0|
Autolysis | | 1 2.0|
Basophilic Focus | X | 9 1.0|
Clear Cell Focus | | 3 1.0|
Degeneration | 1 1 1 | 7 1.1|
Eosinophilic Focus | X | 4 |
Fatty Change | 1 2 | 9 1.8|
Hepatodiaphragmatic Nodule | X X | 7 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic Active | 1 1 | 16 1.1|
Mixed Cell Focus | X | 1 |
Pigmentation | | 2 1.0|
Bile Duct, Hyperplasia | 1 3 1 1 1 1 1 1 1 1 | 52 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 7| 7| 6| 4| | |
DAY ON TEST | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5| | |
| 2| 5| 7| 4| 3| 5| 5| 5| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fibrosis | 2 | 7 2.1|
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | | 3 2.3|
Necrosis, Liquifactive | 3 | 5 2.2|
Artery, Inflammation, Chronic | | 2 1.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Atrophy | 2 | 3 1.3|
Cytoplasmic Alteration | 1 1 | 2 1.0|
Inflammation, Chronic | 1 | 5 1.0|
Inflammation, Chronic Active | 1 1 | 16 1.0|
Vacuolization Cytoplasmic | 2 | 10 1.6|
Acinus, Atrophy | 1 1 1 1 | 22 1.2|
Acinus, Hyperplasia | 3 | 5 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Duct, Submandibular Gland, | | |
Hyperplasia | 1 | 7 1.1|
Duct, Submandibular Gland, | | |
Inflammation, Chronic Active | 1 | 3 1.0|
Duct, Submandibular Gland, | | |
Metaplasia, Squamous | 1 1 | 11 1.3|
Sublingual Gland, Inflammation, | | |
Chronic Active | 1 | 4 1.0|
Submandibular Gland, Atrophy | | 1 2.0|
Submandibular Gland, Inflammation, | | |
Chronic | | 6 1.0|
Submandibular Gland, Inflammation, | | |
Chronic Active | 1 1 1 1 | 18 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Acanthosis | 1 | 1 1.0|
Autolysis | | 1 4.0|
Hyperkeratosis | 2 1 | 4 1.8|
Hyperplasia, Squamous | 3 1 | 7 2.1|
Inflammation, Chronic Active | | 4 2.0|
Ulcer | | 2 3.0|
Muscularis, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Autolysis | | 2 3.0|
Fibrosis | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 7| 7| 6| 4| | |
DAY ON TEST | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5| | |
| 2| 5| 7| 4| 3| 5| 5| 5| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 4 1.3|
Metaplasia, Squamous | | 1 2.0|
Ulcer, Acute | | 1 2.0|
Mucosa, Dilatation | 1 2 1 1 1 2 1 1 | 40 1.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Abscess | | 1 2.0|
Autolysis | | 1 2.0|
Cardiomyopathy | 2 2 1 2 2 2 2 2 2 2 | 58 2.0|
Mineralization | | 1 1.0|
Atrium, Thrombosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | 1 | 8 1.3|
Autolysis | | 1 4.0|
Hyperplasia | 2 1 | 8 1.5|
Vacuolization Cytoplasmic | 2 2 | 22 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 57 |
Autolysis | | 1 4.0|
Hyperplasia | 1 | 13 1.5|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 57 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + | 56 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Autolysis | | 1 3.0|
Pars Distalis, Cyst | 3 | 4 2.0|
Pars Distalis, Hyperplasia | 2 1 1 2 2 2 | 25 1.4|
Pars Intermedia, Angiectasis | 3 | 1 3.0|
Pars Intermedia, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Autolysis | | 1 4.0|
Inflammation, Chronic Active | | 1 1.0|
Pigmentation | | 3 1.0|
C-Cell, Hyperplasia | 1 2 3 1 | 18 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 7| 7| 6| 4| | |
DAY ON TEST | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5| | |
| 2| 5| 7| 4| 3| 5| 5| 5| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + | 10 |
Atrophy | 3 | 5 2.6|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
Autolysis | | 1 4.0|
Inflammation, Chronic Active | | 3 1.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 57 |
Autolysis | | 1 2.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 3 1.0|
Inflammation, Chronic Active | 1 2 2 4 1 1 2 2 2 | 46 1.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
Dilatation | | 1 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 4 3 1 2 3 4 2 | 39 2.1|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Atrophy | 2 2 2 2 2 2 2 | 33 2.1|
Autolysis | | 1 2.0|
Inflammation, Chronic Active | | 2 1.5|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Hemorrhage | | 1 1.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 | 37 1.1|
Seminiferous Tubule, Atrophy | 4 2 2 4 3 4 4 | 33 3.4|
Seminiferous Tubule, Mineralization | 1 1 1 1 1 | 22 1.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Calvarium, Myelofibrosis | | 1 4.0|
Sternal, Autolysis | | 1 4.0|
Sternal, Hypocellularity | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 7| 7| 6| 4| | |
DAY ON TEST | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5| | |
| 2| 5| 7| 4| 3| 5| 5| 5| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Sternal, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Pancreatic, Hemorrhage | 1 | 2 1.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 1 | 5 1.0|
Pancreatic, Pigmentation | 1 | 4 1.0|
Pancreatic, Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 22 |
Hyperplasia, Lymphoid | 1 | 2 1.5|
Hyperplasia, Plasma Cell | | 4 2.5|
Infiltration Cellular, Histiocyte | | 1 1.0|
Sinus, Ectasia | 2 | 6 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 | 56 1.1|
Pigmentation | 1 | 9 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Depletion Lymphoid | 2 2 3 2 2 3 | 19 2.7|
Fibrosis | 1 2 | 8 1.6|
Hyperplasia, Lymphoid | | 1 1.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Necrosis, Coagulative | | 1 2.0|
Capsule, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + | 50 |
Angiectasis | | 1 2.0|
Depletion Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + M + | 47 |
Galactocele | 4 3 | 3 3.3|
Hyperplasia | 1 2 3 2 3 4 1 | 43 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Lip, Inflammation, Acute, Necrotizing| | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 7| 7| 6| 4| | |
DAY ON TEST | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5| | |
| 2| 5| 7| 4| 3| 5| 5| 5| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Abscess | | 1 1.0|
Autolysis | | 1 2.0|
Cerebellum, Infarct | | 2 2.5|
Cerebrum, Infarct | | 1 2.0|
Pons, Infarct | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Autolysis | | 1 2.0|
Congestion | | 1 2.0|
Foreign Body | | 2 2.0|
Infiltration Cellular, Histiocyte | 1 | 9 1.0|
Inflammation, Chronic Active | 2 | 5 2.4|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 | 27 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 1 1 2 1 4 1 2 1 | 36 2.0|
Metaplasia, Squamous | 2 1 | 13 1.8|
Lumen, Foreign Body | 1 | 3 1.7|
Lumen, Inflammation, Acute | | 3 2.0|
Mucosa, Submucosa, Inflammation, | | |
Chronic Active | | 2 2.0|
Mucosa, Submucosa, Lumen, | | |
Inflammation, Chronic Active | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 3 | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + + | 15 |
Cataract | | 2 3.5|
Phthisis Bulbi | | 1 3.0|
Anterior Chamber, Hemorrhage | | 1 4.0|
Retina, Degeneration | | 2 4.0|
Sclera, Metaplasia, Osseous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 7| 7| 6| 4| | |
DAY ON TEST | 3| 9| 8| 4| 6| 3| 3| 3| 9| 5| | |
| 2| 5| 7| 4| 3| 5| 5| 5| 6| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Abscess | | 1 3.0|
Autolysis | | 2 3.0|
Congestion | | 1 1.0|
Cyst | | 3 1.7|
Glomerulosclerosis | | 1 4.0|
Nephropathy | 2 4 3 3 3 2 3 3 4 2 | 58 2.5|
Artery, Mineralization | | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | 1 1 1 1 | 10 1.0|
Renal Tubule, Inflammation, Acute | | 1 1.0|
Renal Tubule, Mineralization | | 1 2.0|
Transitional Epithelium, Hyperplasia | 2 2 1 2 1 1 1 | 19 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Autolysis | | 2 2.5|
Calculus Micro Observation Only | 2 | 4 2.3|
Inflammation, Chronic Active | | 3 1.0|
Polyarteritis | | 1 2.0|
Artery, Necrosis, Fibrinoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 6| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 1| 3| 3| 5| 5| 5| 3| 3| 9| 8| 4| 3| 3| 1| 9| 1| 1| 9| 4| 5| 5|
| 1| 1| 1| 3| 5| 1| 1| 9| 9| 6| 1| 1| 0| 2| 9| 1| 0| 8| 6| 2| 8| 6| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Glandular | |
Parasite Metazoan | 1 2 1 1 1 |
Epithelium, Pigmentation | 1 |
Submucosa, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | 1 1 2 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | 1 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 2 2 2 |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 4 |
Muscularis, Hyperplasia | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Basophilic Focus | X X X |
Clear Cell Focus | 1 1 1 |
Degeneration | 1 1 1 |
Eosinophilic Focus | X X X |
Fatty Change | 1 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Inflammation, Chronic Active | 1 1 1 2 2 1 |
Mixed Cell Focus | |
Pigmentation | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Mesentery | + |
Fibrosis | |
Inflammation, Chronic Active | |
Necrosis, Liquifactive | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 6| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 1| 3| 3| 5| 5| 5| 3| 3| 9| 8| 4| 3| 3| 1| 9| 1| 1| 9| 4| 5| 5|
| 1| 1| 1| 3| 5| 1| 1| 9| 9| 6| 1| 1| 0| 2| 9| 1| 0| 8| 6| 2| 8| 6| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Autolysis | |
Cytoplasmic Alteration | 1 |
Inflammation, Chronic Active | 1 1 1 2 1 2 1 1 1 |
Polyarteritis | 3 2 |
Vacuolization Cytoplasmic | 2 1 1 |
Acinus, Atrophy | 2 1 2 1 1 1 1 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
Duct, Submandibular Gland, | |
Hyperplasia | 1 1 3 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 2 2 2 1 |
Submandibular Gland, Fibrosis | 2 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 1 |
Hyperplasia, Squamous | 4 2 |
Ulcer | 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | |
Necrosis, Coagulative | 2 |
Epithelium, Pigmentation | 1 |
Mucosa, Dilatation | 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2 2 1 |
__________________________________________________________________________|
Tongue | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 1 2 1 2 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 1 2 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 1 2 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 6| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 1| 3| 3| 5| 5| 5| 3| 3| 9| 8| 4| 3| 3| 1| 9| 1| 1| 9| 4| 5| 5|
| 1| 1| 1| 3| 5| 1| 1| 9| 9| 6| 1| 1| 0| 2| 9| 1| 0| 8| 6| 2| 8| 6| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Necrosis, Coagulative | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + M + + + + + + + + + |
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Autolysis | |
Pars Distalis, Cyst | 1 2 |
Pars Distalis, Hyperplasia | 2 1 1 2 2 2 1 |
Pars Intermedia, Angiectasis | 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Pigmentation | 1 |
C-Cell, Hyperplasia | 1 2 1 2 1 4 1 |
Follicular Cell, Cyst | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 2 2 1 1 1 1 2 1 2 2 1 1 2 2 1 3 |
Duct, Dilatation | 2 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 1 3 1 1 4 1 1 2 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + |
Atrophy | 3 3 3 3 3 3 2 3 4 3 3 3 3 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + |
Polyarteritis | 4 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4 4 3 4 3 4 3 4 4 4 4 4 1 |
Seminiferous Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
Sternal, Autolysis | |
Sternal, Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 6| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 1| 3| 3| 5| 5| 5| 3| 3| 9| 8| 4| 3| 3| 1| 9| 1| 1| 9| 4| 5| 5|
| 1| 1| 1| 3| 5| 1| 1| 9| 9| 6| 1| 1| 0| 2| 9| 1| 0| 8| 6| 2| 8| 6| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 1 1 |
Hyperplasia, Plasma Cell | 2 2 |
Sinus, Ectasia | 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1|
Sinus, Ectasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Congestion | |
Depletion Lymphoid | 4 1 |
Fibrosis | 3 2 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + M |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + M M + + + + + + + + + |
Galactocele | 2 |
Hyperplasia | 1 2 1 1 2 2 2 3 1 1 2 2 1 1 2 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 |
Hyperkeratosis | 4 |
Hyperplasia, Basal Cell | 2 |
Inflammation, Acute, Necrotizing | 4 |
Foot, Acanthosis | 1 |
Foot, Hyperkeratosis | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Cranium, Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Gliosis | 1 |
Infarct | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 6| 6| 4| 4|
DAY ON TEST | 3| 3| 3| 2| 1| 3| 3| 5| 5| 5| 3| 3| 9| 8| 4| 3| 3| 1| 9| 1| 1| 9| 4| 5| 5|
| 1| 1| 1| 3| 5| 1| 1| 9| 9| 6| 1| 1| 0| 2| 9| 1| 0| 8| 6| 2| 8| 6| 8| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 2 1 |
Inflammation, Chronic Active | 4 2 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 4 1 1 4 3 1 1 1 1 1 3 4 1 |
Metaplasia, Squamous | 2 3 2 2 |
Lumen, Foreign Body | 2 |
Mucosa, Ulcer | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Cyst | 2 |
Nephropathy | 4 3 3 3 4 3 3 4 4 2 2 1 3 3 2 2 3 3 3 2 |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 1 1 |
Transitional Epithelium, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
Autolysis | |
Polyarteritis | 2 |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 0| 5| 1| 3| 3| 0| 5| 8| 3| 2| 5| 1| 5| 3| 2| 0| 3| 3| 3| 2| 0| 9| 5|
| 1| 1| 7| 2| 1| 2| 1| 4| 8| 8| 1| 1| 8| 9| 6| 1| 2| 3| 4| 7| 1| 2| 3| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia, Glandular | 4 |
Parasite Metazoan | 1 1 1 1|
Epithelium, Pigmentation | |
Submucosa, Inflammation, Chronic | |
Active | 1|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 1 1 1 1 1|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 4 |
Hyperplasia, Lymphoid | 2 |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Inflammation, Chronic | |
Muscularis, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Clear Cell Focus | |
Degeneration | 1 1 |
Eosinophilic Focus | X 2 |
Fatty Change | 1 2 1 1 2 1 |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia | 3 3 3 4 |
Inflammation, Chronic Active | 1 1 1 1 1 1|
Mixed Cell Focus | X |
Pigmentation | |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 1 2 1 1 2 2 1 1 3 1 1 2 1 1 1|
__________________________________________________________________________|
Mesentery | + + |
Fibrosis | 2 |
Inflammation, Chronic Active | 4 |
Necrosis, Liquifactive | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 0| 5| 1| 3| 3| 0| 5| 8| 3| 2| 5| 1| 5| 3| 2| 0| 3| 3| 3| 2| 0| 9| 5|
| 1| 1| 7| 2| 1| 2| 1| 4| 8| 8| 1| 1| 8| 9| 6| 1| 2| 3| 4| 7| 1| 2| 3| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Autolysis | 3 |
Cytoplasmic Alteration | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 |
Polyarteritis | |
Vacuolization Cytoplasmic | 1 2 2 |
Acinus, Atrophy | 2 3 1 1 1 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + M + + + + + + + + + + + + + + + + + + + + |
Duct, Submandibular Gland, | |
Hyperplasia | 3 2 1 1 2 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | 1 |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 2 1 1 1 2 1 |
Submandibular Gland, Fibrosis | |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 1 1 1 |
Hyperplasia, Squamous | 1 2 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Fibrosis | 2 |
Necrosis, Coagulative | 1 1 |
Epithelium, Pigmentation | |
Mucosa, Dilatation | 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Tongue | + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 2 3 1 3 2 2 1 1 2 2 1 1 1 3 2 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 2 |
Vacuolization Cytoplasmic | 1 1 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 1 1 |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 0| 5| 1| 3| 3| 0| 5| 8| 3| 2| 5| 1| 5| 3| 2| 0| 3| 3| 3| 2| 0| 9| 5|
| 1| 1| 7| 2| 1| 2| 1| 4| 8| 8| 1| 1| 8| 9| 6| 1| 2| 3| 4| 7| 1| 2| 3| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + I + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Autolysis | 3 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 1 2 2 2 1 2 2 1 1 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Pigmentation | 1 |
C-Cell, Hyperplasia | 1 1 1 1 1 2 1 1 2 1 |
Follicular Cell, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + M + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 1 2 2 1 2 1 1 2 1 2 1 2 2 1 2 1 2 2 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 2 4 2 2 2 1 3 1 2 1 2 2 2 1 |
Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 3 4 3 2 3 3 4 2 4 3 3 2 2 4 3 4 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Polyarteritis | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1|
Seminiferous Tubule, Atrophy | 4 4 3 3 4 4 3 4 3 4 4 4 3 2 4 4 3 4 4|
Seminiferous Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + |
Sternal, Autolysis | 2 |
Sternal, Myelofibrosis | 1 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 0| 5| 1| 3| 3| 0| 5| 8| 3| 2| 5| 1| 5| 3| 2| 0| 3| 3| 3| 2| 0| 9| 5|
| 1| 1| 7| 2| 1| 2| 1| 4| 8| 8| 1| 1| 8| 9| 6| 1| 2| 3| 4| 7| 1| 2| 3| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pigmentation | 1 2|
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Congestion | 2|
Depletion Lymphoid | 4 4 3 3 3 4 4 4 1 3 4 3 3 |
Fibrosis | 3 1 3 2 1 3 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + I + + + + + + |
Ectopic Parathyroid Gland | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + + + M + + + + + + + + + + + + + |
Galactocele | 2 2 |
Hyperplasia | 2 1 3 1 2 2 1 3 2 1 2 2 2 2 3 2 2 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Inflammation, Acute, Necrotizing | |
Foot, Acanthosis | |
Foot, Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + |
Cranium, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + |
Gliosis | |
Infarct | 1 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 6| 5| 4| 7| 7| 7| 5| 3| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 0| 5| 1| 3| 3| 0| 5| 8| 3| 2| 5| 1| 5| 3| 2| 0| 3| 3| 3| 2| 0| 9| 5|
| 1| 1| 7| 2| 1| 2| 1| 4| 8| 8| 1| 1| 8| 9| 6| 1| 2| 3| 4| 7| 1| 2| 3| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2,000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1|
Foreign Body | |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | |
Artery, Mineralization | 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 4 4 1 1 2 1 1 2 1 1 1 4 3 1 3 |
Metaplasia, Squamous | 2 3 2 1 2 2 |
Lumen, Foreign Body | 1 1 1 |
Mucosa, Ulcer | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Cyst | 2 1 |
Nephropathy | 2 2 4 2 1 3 4 4 2 2 2 3 2 2 3 3 4 2 2 1 3 3 3 2 |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 |
Transitional Epithelium, Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 3 |
Polyarteritis | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5| | |
| 0| 3| 6| 2| 9| 0| 0| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Autolysis | 3 3 | 3 3.0|
Hyperplasia, Glandular | | 1 4.0|
Parasite Metazoan | 1 1 | 11 1.1|
Epithelium, Pigmentation | | 1 1.0|
Submucosa, Inflammation, Chronic | | |
Active | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | 3 2 | 3 2.7|
Parasite Metazoan | 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Autolysis | 3 | 2 3.0|
Parasite Metazoan | 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | 3 2 | 3 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | 3 2 | 4 3.3|
Hyperplasia, Lymphoid | | 5 2.0|
Epithelium, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | 3 3 | 3 3.3|
Inflammation, Chronic | | 1 4.0|
Muscularis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 57 |
Angiectasis | 2 | 3 1.7|
Basophilic Focus | X X X | 7 |
Clear Cell Focus | | 3 1.0|
Degeneration | 1 | 6 1.0|
Eosinophilic Focus | X | 6 2.0|
Fatty Change | | 8 1.3|
Hepatodiaphragmatic Nodule | X | 6 |
Hyperplasia | | 4 3.3|
Inflammation, Chronic Active | 1 | 13 1.2|
Mixed Cell Focus | | 1 |
Pigmentation | 1 | 2 1.5|
Bile Duct, Hyperplasia | 1 2 1 1 1 2 1 | 48 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5| | |
| 0| 3| 6| 2| 9| 0| 0| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
Necrosis, Liquifactive | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 50 |
Autolysis | 2 | 2 2.5|
Cytoplasmic Alteration | | 1 1.0|
Inflammation, Chronic Active | 1 1 1 | 19 1.1|
Polyarteritis | | 2 2.5|
Vacuolization Cytoplasmic | 2 | 7 1.6|
Acinus, Atrophy | 1 1 1 1 | 22 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 49 |
Duct, Submandibular Gland, | | |
Hyperplasia | | 8 1.8|
Duct, Submandibular Gland, | | |
Inflammation, Chronic Active | | 1 1.0|
Duct, Submandibular Gland, | | |
Metaplasia, Squamous | 2 | 13 1.5|
Submandibular Gland, Fibrosis | | 1 2.0|
Submandibular Gland, Inflammation, | | |
Chronic Active | 1 1 | 12 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 5 1.0|
Hyperplasia, Squamous | | 5 2.2|
Ulcer | | 3 3.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Fibrosis | | 1 2.0|
Necrosis, Coagulative | | 3 1.3|
Epithelium, Pigmentation | | 1 1.0|
Mucosa, Dilatation | 1 1 1 2 1 1 | 45 1.2|
__________________________________________________________________________|____________|
Tongue | | 1 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Cardiomyopathy | 3 1 3 2 2 3 | 48 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5| | |
| 0| 3| 6| 2| 9| 0| 0| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 50 |
Angiectasis | | 6 1.5|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | | 3 1.3|
Vacuolization Cytoplasmic | 1 1 | 16 1.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 50 |
Hyperplasia | 1 | 8 1.5|
Inflammation, Chronic Active | | 1 1.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 50 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 47 |
Hyperplasia | | 5 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 51 |
Pars Distalis, Autolysis | | 1 3.0|
Pars Distalis, Cyst | 1 | 4 1.3|
Pars Distalis, Hyperplasia | 2 1 | 19 1.6|
Pars Intermedia, Angiectasis | | 1 2.0|
Pars Intermedia, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 50 |
Pigmentation | | 2 1.0|
C-Cell, Hyperplasia | 1 1 2 | 20 1.4|
Follicular Cell, Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 50 |
Inflammation, Chronic Active | 1 | 3 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 51 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 1 2 1 2 1 2 | 46 1.5|
Duct, Dilatation | | 4 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5| | |
| 0| 3| 6| 2| 9| 0| 0| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 | 26 1.7|
Epithelium, Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 50 |
Atrophy | 3 1 | 34 3.1|
__________________________________________________________________________|____________|
Testes | + + + + + + + | 53 |
Polyarteritis | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 | 27 1.0|
Seminiferous Tubule, Atrophy | 3 4 4 3 | 41 3.6|
Seminiferous Tubule, Mineralization | 1 | 20 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 50 |
Sternal, Autolysis | | 1 2.0|
Sternal, Myelofibrosis | | 5 1.6|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 15 |
Hemorrhage | 1 3 | 3 2.0|
Hyperplasia, Lymphoid | | 3 1.3|
Hyperplasia, Plasma Cell | | 2 2.0|
Sinus, Ectasia | | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 3 1.7|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 | 58 1.0|
Pigmentation | 1 1 1 | 10 1.1|
Sinus, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 52 |
Autolysis | | 1 3.0|
Congestion | | 1 2.0|
Depletion Lymphoid | 3 4 | 17 3.2|
Fibrosis | | 10 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 48 |
Ectopic Parathyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + + M M | 39 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5| | |
| 0| 3| 6| 2| 9| 0| 0| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Galactocele | | 3 2.0|
Hyperplasia | 1 2 | 36 1.8|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + | 51 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 4.0|
Hyperplasia, Basal Cell | | 1 2.0|
Inflammation, Acute, Necrotizing | | 1 4.0|
Foot, Acanthosis | | 1 1.0|
Foot, Hyperkeratosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 50 |
Cranium, Hyperostosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 50 |
Gliosis | | 1 1.0|
Infarct | 2 3 | 4 1.8|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 57 |
Congestion | | 1 1.0|
Foreign Body | | 1 1.0|
Infiltration Cellular, Histiocyte | | 8 1.1|
Inflammation, Chronic Active | | 2 3.0|
Artery, Mineralization | 1 1 1 1 1 | 24 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 50 |
Inflammation, Chronic Active | 1 1 | 31 1.9|
Metaplasia, Squamous | | 10 2.1|
Lumen, Foreign Body | | 4 1.3|
Mucosa, Ulcer | | 4 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 4| 7| 6| 5| 4| 4| | |
DAY ON TEST | 3| 8| 0| 0| 5| 1| 6| 8| 5| 5| | |
| 0| 3| 6| 2| 9| 0| 0| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
2,000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 52 |
Autolysis | | 1 2.0|
Cyst | 2 | 4 1.8|
Nephropathy | 2 2 2 2 4 3 2 2 | 52 2.6|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | 1 | 5 1.0|
Transitional Epithelium, Hyperplasia | 1 2 | 16 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 50 |
Autolysis | | 1 3.0|
Polyarteritis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|
DAY ON TEST | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|
| 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | 1 1 1 1 1 1 |
Polyarteritis | |
Ulcer | 1 |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | 4 |
Hyperplasia, Glandular | 2 |
Inflammation, Chronic Active | 4 |
Ulcer, Multiple | 4 |
Epithelium, Pigmentation | 1 1 |
Peyer's Patch, Hyperplasia | |
Submucosa, Inflammation, Acute | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic | 3 |
Muscularis, Hyperplasia | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 1 |
Autolysis | |
Basophilic Focus | X X X X |
Clear Cell Focus | X X |
Degeneration | 1 1 1 1 1 1 2 1 1 |
Eosinophilic Focus | X X X 1 |
Fatty Change | 2 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 3 2 |
Inflammation, Chronic Active | 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 1 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|
DAY ON TEST | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|
| 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Bile Duct, Hyperplasia | 1 1 1 2 2 1 1 2 1 1 1 1 1 1 1 3 2 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosis | 2 4 2 |
Inflammation, Chronic Active | 2 4 2 |
Necrosis, Liquifactive | 2 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cytoplasmic Alteration | 2 |
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Polyarteritis | 4 2 |
Vacuolization Cytoplasmic | 2 1 |
Acinus, Atrophy | 1 1 1 2 1 2 1 2 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Hyperplasia | |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 1 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 |
Submandibular Gland, Necrosis, | |
Coagulative | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Inflammation, | |
Chronic Active | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperkeratosis | |
Hyperplasia, Squamous | 2 2 |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | |
Hemorrhage | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Necrosis, Coagulative | 4 |
Epithelium, Pigmentation | |
Mucosa, Dilatation | 2 2 2 1 2 1 1 1 2 2 1 1 2 1 1 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|
DAY ON TEST | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|
| 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2|
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Thrombosis | 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Autolysis | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 1 |
Vacuolization Cytoplasmic | 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 1 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + +|
Autolysis | |
Pars Distalis, Angiectasis | 2 1 |
Pars Distalis, Cyst | 1 |
Pars Distalis, Hyperplasia | 1 2 2 1 2 1|
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Pigmentation | 1 |
C-Cell, Hyperplasia | 1 1 1 2 1 1 2 1 |
Follicular Cell, Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 1 1 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|
DAY ON TEST | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|
| 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | 1 2 1 1 1 2 1 3 1 |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 2 3 2 2 2 2 3 3 3 3 2 2 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hemorrhage | 2 |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 1 1 |
Seminiferous Tubule, Atrophy | 3 4 4 2 4 4 4 4 4 4 3 4 3 3 1 4 4 |
Seminiferous Tubule, Mineralization | 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + M + + + + + + +|
Sternal, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 1 |
Pancreatic, Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + |
Autolysis | |
Hemorrhage | 1 3 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 1 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 |
Sinus, Ectasia | 1 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Depletion Lymphoid | 2 2 4 2 2 1 2 4 |
Fibrosis | 2 2 2 2 1 1 3 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|
DAY ON TEST | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|
| 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + +|
Autolysis | |
Cyst | 1 |
Depletion Lymphoid | |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + + + + + + + + + + M + + +|
Galactocele | |
Hyperplasia | 1 2 2 2 1 3 1 1 2 2 2 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | 2 |
Hyperkeratosis | 4 |
Subcutaneous Tissue, Necrosis, | |
Liquifactive | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Infarct | |
Thrombosis | 2 |
Cerebrum, Infarct | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | |
Foreign Body | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Chronic Active | |
Thrombosis | 4 |
Alveolar Epithelium, Hyperplasia | 2 2 2 1 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 |
Bronchiole, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + M + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 1 3 3 2 1 3 1 1 3 1 2 1 1 2|
Metaplasia, Squamous | 2 2 1|
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 6| 4| 4| 7| 7| 6| 6| 4| 7| 6| 5| 4| 4| 6| 6| 5| 4| 3|
DAY ON TEST | 3| 3| 3| 2| 0| 0| 5| 4| 5| 5| 3| 3| 6| 6| 5| 3| 7| 6| 5| 5| 8| 7| 8| 5| 3|
| 0| 0| 0| 2| 3| 7| 4| 5| 9| 6| 0| 0| 7| 2| 9| 0| 4| 8| 9| 9| 2| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Glands, Hyperplasia | 2 |
Lumen, Foreign Body | 1|
Lumen, Inflammation, Acute | 4 |
Mucosa, Ulcer | 3 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
Autolysis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
Cyst | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Abscess | |
Autolysis | |
Cyst | 1 2 |
Nephropathy | 4 3 2 3 3 2 2 2 4 3 3 4 3 4 2 4 2 3 2|
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 1 1 |
Renal Tubule, Hyperplasia | 1 |
Transitional Epithelium, Hyperplasia | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Cyst | 4 |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|
| 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
Parasite Metazoan | 1 1 1 1 1 1 1 1|
Polyarteritis | 3 |
Ulcer | |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
Parasite Metazoan | 1 1 1 2 1 1 1|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
Parasite Metazoan | 1 1 1 1|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
Fibrosis | |
Hyperplasia, Glandular | |
Inflammation, Chronic Active | |
Ulcer, Multiple | |
Epithelium, Pigmentation | 1 |
Peyer's Patch, Hyperplasia | 2|
Submucosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
Inflammation, Chronic | |
Muscularis, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Autolysis | 3 |
Basophilic Focus | X X X X X |
Clear Cell Focus | X |
Degeneration | 1 2 1 1 1 2 1 |
Eosinophilic Focus | X X |
Fatty Change | 2 |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia | 3 |
Inflammation, Chronic Active | 1 1 1|
Mixed Cell Focus | 1 X X X |
Necrosis, Coagulative | |
Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|
| 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Bile Duct, Hyperplasia | 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 3 1 1 1 2 |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosis | 4 3 3 |
Inflammation, Chronic Active | 2 2 |
Necrosis, Liquifactive | 4 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 4 |
Cytoplasmic Alteration | |
Inflammation, Chronic Active | 1 1 1 1 |
Polyarteritis | 2 |
Vacuolization Cytoplasmic | 1 2 |
Acinus, Atrophy | 2 2 4 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + |
Duct, Submandibular Gland, | |
Hyperplasia | 2 1 |
Duct, Submandibular Gland, | |
Inflammation, Chronic Active | 1 |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 2 1 1 1 |
Submandibular Gland, Necrosis, | |
Coagulative | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lamina Propria, Inflammation, | |
Chronic Active | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + I + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperkeratosis | 1 1 |
Hyperplasia, Squamous | 2 2 |
Inflammation, Chronic Active | 2 |
Ulcer | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 3 |
Fibrosis | 2 |
Hemorrhage | 1 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Necrosis, Coagulative | 2 |
Epithelium, Pigmentation | 2 1|
Mucosa, Dilatation | 2 2 1 1 1 1 1 1 2 1 1 1 1 1 2 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|
| 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 3 1 2 1 2 2 2 2 2 2 2 2 1 1 2 2 3 2 2 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Capsule, Thrombosis | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Autolysis | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 2 1 2 1 2 1 1 3 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia | 1 1 2 1 2 1 2 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 4 |
Pigmentation | |
C-Cell, Hyperplasia | 2 1 1 1 1 2 1 1 1 |
Follicular Cell, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 1 1 4 2 2 1 2 2 2 1 1 1 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|
| 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Inflammation, Chronic Active | 3 3 1 1 1 3 2 2 1 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 2 3 1 3 3 3 3 2 2 3 2 3 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Hemorrhage | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 |
Seminiferous Tubule, Atrophy | 4 1 3 4 4 4 4 3 4 4 3 4 3 4 3 |
Seminiferous Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + |
Sternal, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 |
Mediastinal, Pigmentation | 1 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + |
Autolysis | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Pigmentation | 1|
Sinus, Ectasia | 3 3 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Depletion Lymphoid | 3 4 3 2 2 3 2 3 3 3 4 4 4 |
Fibrosis | 1 2 2 1 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|
| 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Thymus | + M + + + M + + + + + + + + + + + + + + + + + |
Autolysis | 3 |
Cyst | 1 |
Depletion Lymphoid | 2 |
Ectopic Parathyroid Gland | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + M M M + + M + + + M + |
Galactocele | 3 |
Hyperplasia | 2 1 2 2 2 3 1 2 2 3 2 1 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + |
Abscess | 4 |
Acanthosis | |
Hyperkeratosis | |
Subcutaneous Tissue, Necrosis, | |
Liquifactive | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Infarct | 3 2 |
Thrombosis | |
Cerebrum, Infarct | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 2 |
Fibrosis | 1 |
Foreign Body | |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Chronic Active | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
Artery, Mineralization | 1 1 1 1 |
Bronchiole, Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 1 3 3 1 1 1 2 2 1 1 1 1 1 4 2 4 3 |
Metaplasia, Squamous | 3 2 |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 1| 7| 6| 6| 5| 4| 4| 7| 7| 4| 1| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 6| 4| 7| 9| 3| 3| 3| 5| 4| 1| 9| 9| 9| 5| 6| 3| 3| 6| 9| 3| 3| 3| 8| 5|
| 0| 1| 8| 9| 9| 0| 0| 4| 6| 1| 5| 7| 5| 4| 6| 7| 0| 0| 4| 9| 0| 0| 0| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10,000 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Glands, Hyperplasia | |
Lumen, Foreign Body | |
Lumen, Inflammation, Acute | |
Mucosa, Ulcer | 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | I + |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
Cyst | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + |
Abscess | 2 |
Autolysis | 3 4 |
Cyst | |
Nephropathy | 2 2 3 2 2 3 3 3 2 4 4 4 2 1 3 3 2 2 2 3 3 |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 1 1 1 1 |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + |
Autolysis | 4 |
Calculus Gross Observation | X |
Calculus Micro Observation Only | 3 2 |
Cyst | |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5| | |
| 5| 7| 3| 2| 6| 0| 2| 2| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 2 3.5|
Parasite Metazoan | 1 1 | 16 1.0|
Polyarteritis | | 1 3.0|
Ulcer | | 1 1.0|
Epithelium, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Autolysis | | 2 3.5|
Parasite Metazoan | 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Autolysis | | 2 3.5|
Parasite Metazoan | 1 1 | 7 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 59 |
Autolysis | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 59 |
Autolysis | | 2 3.5|
Fibrosis | 2 | 2 3.0|
Hyperplasia, Glandular | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
Ulcer, Multiple | | 1 4.0|
Epithelium, Pigmentation | 1 | 4 1.0|
Peyer's Patch, Hyperplasia | | 1 2.0|
Submucosa, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 59 |
Autolysis | | 2 3.5|
Inflammation, Chronic | | 1 3.0|
Muscularis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 56 |
Angiectasis | | 5 1.2|
Autolysis | | 1 3.0|
Basophilic Focus | X | 10 |
Clear Cell Focus | | 3 |
Degeneration | 1 | 17 1.2|
Eosinophilic Focus | X | 7 1.0|
Fatty Change | 1 2 2 | 6 1.7|
Hepatodiaphragmatic Nodule | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5| | |
| 5| 7| 3| 2| 6| 0| 2| 2| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 3 2.7|
Inflammation, Chronic Active | 1 | 9 1.0|
Mixed Cell Focus | X | 5 1.0|
Necrosis, Coagulative | | 1 1.0|
Pigmentation | 1 | 2 1.0|
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 | 45 1.2|
__________________________________________________________________________|____________|
Mesentery | | 8 |
Fibrosis | | 6 3.0|
Inflammation, Chronic Active | | 5 2.4|
Necrosis, Liquifactive | | 6 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Autolysis | | 2 3.0|
Cytoplasmic Alteration | | 1 2.0|
Inflammation, Chronic Active | | 10 1.0|
Polyarteritis | 3 | 4 2.8|
Vacuolization Cytoplasmic | 1 1 | 6 1.3|
Acinus, Atrophy | 1 1 1 | 24 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Duct, Submandibular Gland, | | |
Hyperplasia | 1 | 3 1.3|
Duct, Submandibular Gland, | | |
Inflammation, Chronic Active | | 1 1.0|
Duct, Submandibular Gland, | | |
Metaplasia, Squamous | | 5 1.0|
Submandibular Gland, Inflammation, | | |
Chronic Active | 1 1 1 | 11 1.1|
Submandibular Gland, Necrosis, | | |
Coagulative | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
Lamina Propria, Inflammation, | | |
Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 53 |
Autolysis | | 1 3.0|
Hyperkeratosis | | 2 1.0|
Hyperplasia, Squamous | | 4 2.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Autolysis | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5| | |
| 5| 7| 3| 2| 6| 0| 2| 2| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
Hemorrhage | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
Necrosis, Coagulative | | 2 3.0|
Epithelium, Pigmentation | 1 | 3 1.3|
Mucosa, Dilatation | 2 1 1 1 2 1 1 | 38 1.4|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Cardiomyopathy | 2 2 2 1 3 3 1 1 | 48 2.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 51 |
Capsule, Thrombosis | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Angiectasis | 1 | 4 1.3|
Autolysis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | | 3 1.0|
Vacuolization Cytoplasmic | 2 | 16 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 51 |
Autolysis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 1 1 | 13 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 48 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 49 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 50 |
Autolysis | | 1 2.0|
Pars Distalis, Angiectasis | | 2 1.5|
Pars Distalis, Cyst | | 2 2.0|
Pars Distalis, Hyperplasia | 2 2 2 1 | 17 1.5|
Pars Intermedia, Angiectasis | | 1 3.0|
Pars Intermedia, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5| | |
| 5| 7| 3| 2| 6| 0| 2| 2| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Autolysis | | 1 4.0|
Pigmentation | | 1 1.0|
C-Cell, Hyperplasia | 1 | 18 1.2|
Follicular Cell, Cyst | | 2 2.0|
Follicular Cell, Hyperplasia | 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 50 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 2 2 2 | 45 1.6|
Duct, Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 50 |
Autolysis | | 1 2.0|
Inflammation, Chronic Active | 1 4 1 3 4 | 24 1.8|
Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 51 |
Atrophy | 3 3 2 | 32 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 54 |
Autolysis | | 1 2.0|
Hemorrhage | | 1 2.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 | 29 1.0|
Seminiferous Tubule, Atrophy | 4 4 3 3 2 2 | 38 3.4|
Seminiferous Tubule, Mineralization | 1 1 1 1 1 1 | 23 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 49 |
Sternal, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Bronchial, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hemorrhage | 3 | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Mediastinal, Pigmentation | | 1 1.0|
Pancreatic, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5| | |
| 5| 7| 3| 2| 6| 0| 2| 2| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocyte | 1 | 2 1.0|
Pancreatic, Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 22 |
Autolysis | | 1 2.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Hyperplasia, Plasma Cell | | 2 1.5|
Sinus, Ectasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 2 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 | 56 1.1|
Pigmentation | 1 1 | 9 1.0|
Sinus, Ectasia | 2 1 | 9 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Autolysis | | 1 2.0|
Depletion Lymphoid | 2 3 3 2 3 | 26 2.8|
Fibrosis | 1 | 12 1.7|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + I + I + + + + | 45 |
Autolysis | | 1 3.0|
Cyst | | 2 1.0|
Depletion Lymphoid | | 1 2.0|
Ectopic Parathyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + | 40 |
Galactocele | | 1 3.0|
Hyperplasia | 1 2 2 1 2 2 2 | 36 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 53 |
Abscess | | 1 4.0|
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 4.0|
Subcutaneous Tissue, Necrosis, | | |
Liquifactive | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5| | |
| 5| 7| 3| 2| 6| 0| 2| 2| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Autolysis | | 1 2.0|
Infarct | | 2 2.5|
Thrombosis | | 1 2.0|
Cerebrum, Infarct | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 57 |
Autolysis | | 1 2.0|
Fibrosis | | 1 1.0|
Foreign Body | 1 | 1 1.0|
Hemorrhage | | 1 1.0|
Infiltration Cellular, Histiocyte | | 8 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Thrombosis | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 4 | 5 2.2|
Artery, Mineralization | 1 1 1 1 1 1 | 22 1.0|
Bronchiole, Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Inflammation, Chronic Active | 4 1 2 2 3 1 1 | 39 1.9|
Metaplasia, Squamous | 2 2 2 2 | 9 2.0|
Glands, Hyperplasia | | 1 2.0|
Lumen, Foreign Body | 2 | 2 1.5|
Lumen, Inflammation, Acute | | 1 4.0|
Mucosa, Ulcer | | 4 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
Autolysis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 6| 5| 4| | |
DAY ON TEST | 1| 8| 5| 3| 5| 3| 2| 1| 3| 5| | |
| 5| 7| 3| 2| 6| 0| 2| 2| 9| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10,000 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Abscess | | 1 2.0|
Autolysis | | 2 3.5|
Cyst | | 2 1.5|
Nephropathy | 3 3 2 2 2 3 2 2 | 48 2.7|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | | 8 1.0|
Renal Tubule, Hyperplasia | | 1 1.0|
Transitional Epithelium, Hyperplasia | 2 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
Autolysis | | 1 4.0|
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 2 2.5|
Cyst | | 1 4.0|
Inflammation, Chronic Active | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|
| 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
Erosion | 1 |
Hyperplasia, Glandular | 1 1 2 1 3 2 1 2 2 3 2 3 1 2 2 1 2 2 2|
Inflammation, Chronic Active | |
Metaplasia, Osseous | |
Parasite Metazoan | 1 1 |
Ulcer | 4 2 3 1 3 1 1 2 2 2 2 1 4 2|
Ulcer, Multiple | 4 |
Epithelium, Pigmentation | 1 |
Lamina Propria, Inflammation, Chronic| 1 |
Mucosa, Ulcer | |
Submucosa, Fatty Change | 4 |
Submucosa, Lamina Propria, | |
Inflammation, Chronic Active | 2 4 1 3 3 2 1 3 2 3 3 2 3 3 3|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
Hyperplasia, Glandular | 2 |
Inflammation, Chronic Active | |
Parasite Metazoan | 1 |
Ulcer | 4 4 |
Submucosa, Epithelium, Proliferation | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4 |
Epithelium, Pigmentation | 1 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 4 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | |
Epithelium, Pigmentation | 1 1 1 1 1 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +|
Autolysis | 4 2 3 2 |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X 1 X X X X X X X X X |
Clear Cell Focus | X |
Degeneration | 2 1 |
Eosinophilic Focus | |
_____________________________________________________________________________________________________________________|
Page 119
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|
| 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fatty Change | 1 2 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 2 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1|
Mixed Cell Focus | |
Necrosis, Coagulative | 1 2 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Mesentery | + + +|
Fibrosis | 2 2|
Inflammation, Chronic Active | 4 2 2|
Necrosis, Liquifactive | 2 2 |
Necrosis | 3|
Artery, Hyperplasia | |
Perivascular, Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Autolysis | 2 |
Cytoplasmic Alteration | 2 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 1 2 1 1 1 |
Pigmentation | 1|
Vacuolization Cytoplasmic | 1 1 1 2 2 |
Acinus, Atrophy | 1 1 1 1 1 1 1 1 |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, Dilatation| 2 |
Duct, Submandibular Gland, | |
Hyperplasia | 2 1 1 |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 |
Sublingual Gland, Inflammation, | |
Chronic Active | |
Submandibular Gland, Atrophy | |
Submandibular Gland, Inflammation, | |
Chronic | 1 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperkeratosis | 1 2 2 4 1 2 2 |
Hyperplasia, Squamous | 2 3 2 4 1 3 3 |
Inflammation, Chronic Active | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 120
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|
| 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 2 |
Ulcer, Multiple | |
Submucosa, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Metaplasia, Squamous | |
Necrosis, Coagulative | 2 |
Epithelium, Pigmentation | 1 1 1 1|
Mucosa, Dilatation | 1 1 1 1 1 1 1 1 1 1 1 2 1 |
Muscularis, Developmental | |
Malformation | 2 |
Muscularis, Submucosa, Inflammation, | |
Chronic Active | |
Submucosa, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Cardiomyopathy | 2 2 2 2 1 2 3 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2|
Congestion | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative | 1 |
Vacuolization Cytoplasmic | 3 1 2 2 1 3 3 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 2 2 1 2 2 |
Necrosis, Coagulative | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Autolysis | 3 |
Pars Distalis, Cyst | 1 1 1 2 |
Pars Distalis, Hyperplasia | 1 2 1 2 2 1 4 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 121
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|
| 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation, Chronic Active | 1 |
Pigmentation | 1 |
C-Cell, Hyperplasia | 1 1 1 1 1|
Follicle, Pigmentation | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + + |
Atrophy | 1 3 3 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1|
Inflammation, Chronic Active | 1 2 1 1 2 1 2 2 1 1 1 1 2 1 1 1 2 2 1 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Fibrosis | |
Inflammation, Acute | 1 3 |
Inflammation, Chronic Active | 2 3 4 3 2 2 2 2 1 2 2 3 4 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 3 2 2 3 3 3 3 3 3 |
Autolysis | 2 |
Cyst | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 1 2 2 1 1 1 1 1 1 1 2|
Seminiferous Tubule, Atrophy | 4 4 4 4 4 3 4 4 4 3 3 4 4 1 |
Seminiferous Tubule, Mineralization | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Hypocellularity | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hemorrhage | 1 |
Pancreatic, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 122
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|
| 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocyte | |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 |
Inflammation, Chronic Active | 2 2 |
Pigmentation | 1 1 |
Sinus, Ectasia | 4 2 3 2 3 3 3 4 3 3 2 3 4 3 4 3 4 4 4 3 4 |
Sinus, Ectasia, Multiple | 4|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Bacterium | 4 |
Depletion Lymphoid | 3 2 3 2 2 |
Fibrosis | 2 1 2 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | M + + M + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Congestion | |
Cyst | 4 |
Depletion Lymphoid | 1 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + + + + + + + M + + + + + + + + + + + +|
Galactocele | |
Hyperplasia | 2 2 1 1 2 1 2 2 1 2 1 2 2 2 2 1 1 2 1 2 2|
Pigmentation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Infarct | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 123
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|
| 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Bronchiectasis | |
Foreign Body | |
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Chronic Active | |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 3|
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1|
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation, Chronic Active | 1 4 2 1 1 1 1 1 1 1 1 |
Metaplasia, Squamous | 2 2 2 |
Lumen, Foreign Body | |
Mucosa, Inflammation, Chronic Active | 2 |
Mucosa, Ulcer | 2 |
Mucosa, Submucosa, Inflammation, | |
Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Nasolacrimal Duct, Metaplasia, | |
Squamous | |
Nasopharyngeal Duct, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 |
Cornea, Neovascularization | |
__________________________________________________________________________|
Lacrimal Gland | + |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Autolysis | 3 3 2 |
Cyst | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 124
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 7| 4| 4| 4| 3| 7| 6| 5| 4| 4| 7| 6| 6| 4| 4| 7| 7| 6| 4| 4|
DAY ON TEST | 2| 7| 3| 1| 2| 2| 8| 5| 0| 6| 2| 6| 6| 5| 5| 2| 9| 8| 5| 5| 3| 1| 1| 9| 5|
| 9| 3| 3| 5| 1| 9| 7| 6| 0| 7| 9| 9| 9| 6| 6| 9| 5| 2| 9| 6| 0| 1| 0| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | |
Nephropathy | 2 2 2 2 1 2 2 1 2 2 2 1 2 1 2 2 2 1 1 2 3 2 1 2|
Adventitia, Inflammation, Chronic | |
Active | |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | |
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Transitional Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Calculus Gross Observation | X |
Calculus Micro Observation Only | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Subserosa, Mineralization | |
_____________________________________________________________________________________________________________________|
Page 125
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|
| 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperkeratosis | 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Erosion | |
Hyperplasia, Glandular | 2 1 1 2 2 2 2 2 2 3 3 2 2 3 3 3 2 2 2 2 2 1|
Inflammation, Chronic Active | 4 |
Metaplasia, Osseous | |
Parasite Metazoan | |
Ulcer | 4 1 4 2 4 2 4 4 3 2 2 1|
Ulcer, Multiple | |
Epithelium, Pigmentation | |
Lamina Propria, Inflammation, Chronic| |
Mucosa, Ulcer | 4 |
Submucosa, Fatty Change | |
Submucosa, Lamina Propria, | |
Inflammation, Chronic Active | 2 4 1 2 1 2 4 1 4 1 2 3 2 2 2 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + M + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Glandular | 1 2 1 |
Inflammation, Chronic Active | 4 1 |
Parasite Metazoan | 1 |
Ulcer | 3 4 2 4 |
Submucosa, Epithelium, Proliferation | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Epithelium, Pigmentation | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic Active | 1 |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Autolysis | 2 2 |
Epithelium, Pigmentation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | |
Degeneration | 1 |
Eosinophilic Focus | X X X |
_____________________________________________________________________________________________________________________|
Page 126
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|
| 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Fatty Change | 2 2 |
Hepatodiaphragmatic Nodule | X X X X X X X X |
Hyperplasia | 2 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 1 1 2 1 1 1 2 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Mesentery | M + + |
Fibrosis | |
Inflammation, Chronic Active | 2 |
Necrosis, Liquifactive | |
Necrosis | |
Artery, Hyperplasia | 3 |
Perivascular, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Autolysis | |
Cytoplasmic Alteration | |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Pigmentation | |
Vacuolization Cytoplasmic | 2 |
Acinus, Atrophy | 1 1 2 1 1 2 1 2 |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, Dilatation| |
Duct, Submandibular Gland, | |
Hyperplasia | |
Duct, Submandibular Gland, | |
Metaplasia, Squamous | 1 1 1 1 |
Sublingual Gland, Inflammation, | |
Chronic Active | 1 |
Submandibular Gland, Atrophy | |
Submandibular Gland, Inflammation, | |
Chronic | 2 2 |
Submandibular Gland, Inflammation, | |
Chronic Active | 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hyperkeratosis | 2 2 2 2 2 2 2 |
Hyperplasia, Squamous | 2 4 4 4 3 3 2 1 |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
Page 127
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|
| 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 4 1 |
Ulcer, Multiple | 4 |
Submucosa, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Metaplasia, Squamous | |
Necrosis, Coagulative | |
Epithelium, Pigmentation | |
Mucosa, Dilatation | 1 1 1 2 1 1 1 1 1 1 1 1 2 1 2 2 1|
Muscularis, Developmental | |
Malformation | |
Muscularis, Submucosa, Inflammation, | |
Chronic Active | 1 |
Submucosa, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cardiomyopathy | 1 2 2 2 1 1 3 2 2 1 2 2 1 2 2 2 3 2 2 2 2 2 |
Congestion | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 |
Necrosis, Coagulative, Focal | |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 2 1 2 2 1 2 1 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 1 1 2 1 2 1 2 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + M + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Autolysis | |
Pars Distalis, Cyst | 1 1 1 |
Pars Distalis, Hyperplasia | 2 1 2 1 2 2 2 2 1 2 1 1|
_____________________________________________________________________________________________________________________|
Page 128
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|
| 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Inflammation, Chronic Active | |
Pigmentation | 1 |
C-Cell, Hyperplasia | 1 1 1 2 2 |
Follicle, Pigmentation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + |
Atrophy | 3 2 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 1 1 1 2 2 2 2 2 1 1 2 2 2 1 2 1|
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | 2|
Inflammation, Acute | 4 |
Inflammation, Chronic Active | 4 2 2 2 3 3 1 2 2 3 1 2 3 1 3 4 2 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 2 3 2 3 3 2 3 3 4 3 |
Autolysis | |
Cyst | 3 |
Epithelium, Hyperplasia | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1|
Seminiferous Tubule, Atrophy | 4 1 4 4 4 4 1 4 4 4 4 4 3 3 1|
Seminiferous Tubule, Mineralization | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sternal, Hypocellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hemorrhage | |
Pancreatic, Infiltration Cellular, | |
_____________________________________________________________________________________________________________________|
Page 129
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|
| 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocyte | 1 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 1 2 2|
Hyperplasia, Plasma Cell | 2 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Inflammation, Chronic Active | 2 4 4 2 4 3 4 4|
Pigmentation | 1 1 |
Sinus, Ectasia | 3 3 4 4 3 3 3 3 4 4 4 4 4 4 4 3 4 4 4 4 3 3 3 3 4|
Sinus, Ectasia, Multiple | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Bacterium | |
Depletion Lymphoid | 4 3 1 3 2 |
Fibrosis | 2 1 2 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Thymus | M + + + + + + + + M + + + + + + + + M + + M + + +|
Autolysis | |
Congestion | |
Cyst | |
Depletion Lymphoid | 3 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + M + M + + M + + + + + + + M + +|
Galactocele | 2 |
Hyperplasia | 3 2 2 2 3 2 2 1 1 2 2 1 2 2 2 2 2 2|
Pigmentation | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemorrhage | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Infarct | 2 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 130
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|
| 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Bronchiectasis | |
Foreign Body | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 2 |
Artery, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 1 4 1 1 1 1 3 4 1 4|
Metaplasia, Squamous | 2 2 2 2|
Lumen, Foreign Body | 1 |
Mucosa, Inflammation, Chronic Active | |
Mucosa, Ulcer | |
Mucosa, Submucosa, Inflammation, | |
Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 2 2 2 |
Nasolacrimal Duct, Metaplasia, | |
Squamous | 3 2 3 2 |
Nasopharyngeal Duct, Inflammation, | |
Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | M + + + + M + |
Cataract | |
Cornea, Neovascularization | 2 |
__________________________________________________________________________|
Lacrimal Gland | + |
Inflammation, Chronic | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Autolysis | |
Cyst | 1 |
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 131
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 2| 7| 7| 7| 4| 4| 6| 6| 5| 4| 3| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4|
DAY ON TEST | 0| 5| 0| 6| 7| 3| 2| 2| 5| 1| 7| 4| 8| 5| 7| 2| 2| 2| 2| 8| 2| 2| 1| 3| 7|
| 4| 6| 4| 8| 0| 0| 9| 9| 9| 4| 6| 0| 0| 6| 4| 9| 9| 9| 9| 2| 9| 9| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
50,000 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | |
Nephropathy | 1 1 1 1 2 4 2 2 2 2 2 2 1 1 3 2 2 3 3 3 4 2 2 2|
Adventitia, Inflammation, Chronic | |
Active | |
Proximal Convoluted Renal Tubule, | |
Inflammation, Acute | 1 1 1 1 1 1 |
Proximal Convoluted Renal Tubule, | |
Pigmentation | |
Transitional Epithelium, Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Calculus Gross Observation | |
Calculus Micro Observation Only | 3 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | 1 |
Subserosa, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 132
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 6| 5| 5| 5| | |
DAY ON TEST | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2| | |
| 9| 9| 8| 6| 1| 9| 5| 2| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + | 58 |
Hyperkeratosis | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Autolysis | | 3 3.3|
Erosion | | 1 1.0|
Hyperplasia, Glandular | 2 1 2 3 2 2 2 1 | 49 2.0|
Inflammation, Chronic Active | | 1 4.0|
Metaplasia, Osseous | 2 | 1 2.0|
Parasite Metazoan | | 2 1.0|
Ulcer | 2 1 2 4 2 2 | 32 2.4|
Ulcer, Multiple | | 1 4.0|
Epithelium, Pigmentation | | 1 1.0|
Lamina Propria, Inflammation, Chronic| | 1 1.0|
Mucosa, Ulcer | | 1 4.0|
Submucosa, Fatty Change | | 1 4.0|
Submucosa, Lamina Propria, | | |
Inflammation, Chronic Active | 2 1 3 3 2 | 36 2.3|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Autolysis | 2 | 3 3.0|
Hyperplasia, Glandular | | 4 1.5|
Inflammation, Chronic Active | | 2 2.5|
Parasite Metazoan | | 2 1.0|
Ulcer | | 6 3.5|
Submucosa, Epithelium, Proliferation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + | 58 |
Autolysis | 2 | 4 2.8|
Epithelium, Pigmentation | | 4 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Autolysis | | 4 2.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Autolysis | | 3 3.3|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic Active | | 1 1.0|
Epithelium, Pigmentation | 2 | 7 1.1|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
Autolysis | | 6 2.5|
Epithelium, Pigmentation | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 133
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 6| 5| 5| 5| | |
DAY ON TEST | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2| | |
| 9| 9| 8| 6| 1| 9| 5| 2| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X | 22 1.0|
Clear Cell Focus | X | 2 |
Degeneration | | 3 1.3|
Eosinophilic Focus | | 3 |
Fatty Change | 2 2 | 7 1.7|
Hepatodiaphragmatic Nodule | X X | 11 |
Hyperplasia | | 3 1.7|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 1 | 19 1.1|
Mixed Cell Focus | X | 1 |
Necrosis, Coagulative | | 2 1.5|
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 2 1 1 | 43 1.1|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Fibrosis | 2 | 3 2.0|
Inflammation, Chronic Active | | 4 2.5|
Necrosis, Liquifactive | | 2 2.0|
Necrosis | | 1 3.0|
Artery, Hyperplasia | | 1 3.0|
Perivascular, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + M + + + + + + + | 59 |
Atrophy | 1 | 3 1.3|
Autolysis | | 1 2.0|
Cytoplasmic Alteration | | 1 2.0|
Inflammation, Chronic | 1 | 5 1.0|
Inflammation, Chronic Active | 1 2 1 1 | 16 1.1|
Pigmentation | | 1 1.0|
Vacuolization Cytoplasmic | | 6 1.5|
Acinus, Atrophy | 2 2 2 1 | 20 1.3|
Acinus, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Duct, Submandibular Gland, Dilatation| | 1 2.0|
Duct, Submandibular Gland, | | |
Hyperplasia | | 3 1.3|
Duct, Submandibular Gland, | | |
Metaplasia, Squamous | 1 | 6 1.0|
Sublingual Gland, Inflammation, | | |
Chronic Active | | 1 1.0|
Submandibular Gland, Atrophy | 2 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 134
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 6| 5| 5| 5| | |
DAY ON TEST | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2| | |
| 9| 9| 8| 6| 1| 9| 5| 2| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Submandibular Gland, Inflammation, | | |
Chronic | | 3 1.7|
Submandibular Gland, Inflammation, | | |
Chronic Active | 2 1 | 11 1.1|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Erosion | | 1 1.0|
Hyperkeratosis | 3 2 | 16 2.1|
Hyperplasia, Squamous | 4 1 1 | 18 2.6|
Inflammation, Chronic Active | 2 | 6 1.3|
Ulcer | 3 1 | 5 2.2|
Ulcer, Multiple | | 1 4.0|
Submucosa, Inflammation, Chronic | | |
Active | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Autolysis | | 1 2.0|
Metaplasia, Squamous | 2 | 1 2.0|
Necrosis, Coagulative | 2 | 2 2.0|
Epithelium, Pigmentation | 1 | 5 1.0|
Mucosa, Dilatation | 1 1 2 1 2 2 | 36 1.2|
Muscularis, Developmental | | |
Malformation | | 1 2.0|
Muscularis, Submucosa, Inflammation, | | |
Chronic Active | | 1 1.0|
Submucosa, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Abscess | | 1 2.0|
Cardiomyopathy | 2 2 2 2 2 2 3 2 2 2 | 57 1.9|
Congestion | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | 2 1 | 9 1.2|
Hematopoietic Cell Proliferation | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 135
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 6| 5| 5| 5| | |
DAY ON TEST | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2| | |
| 9| 9| 8| 6| 1| 9| 5| 2| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 1 | 3 1.0|
Necrosis, Coagulative, Focal | 2 | 1 2.0|
Necrosis, Coagulative | | 1 1.0|
Vacuolization Cytoplasmic | 2 2 | 22 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Hyperplasia | 1 | 15 1.6|
Necrosis, Coagulative | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + M + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | | 1 1.0|
Pars Distalis, Autolysis | | 1 3.0|
Pars Distalis, Cyst | 1 | 8 1.1|
Pars Distalis, Hyperplasia | 1 1 1 | 26 1.6|
Pars Intermedia, Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Autolysis | 2 | 2 2.5|
Inflammation, Chronic Active | | 1 1.0|
Pigmentation | | 2 1.0|
C-Cell, Hyperplasia | 1 1 1 | 13 1.2|
Follicle, Pigmentation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + | 9 |
Atrophy | 3 | 8 2.6|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 4 1.0|
Inflammation, Chronic Active | 2 1 1 1 1 1 2 | 44 1.4|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
Fibrosis | | 1 2.0|
Inflammation, Acute | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 136
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 6| 5| 5| 5| | |
DAY ON TEST | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2| | |
| 9| 9| 8| 6| 1| 9| 5| 2| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 2 1 2 1 1 3 2 | 41 2.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
Atrophy | 3 2 2 3 3 | 30 2.7|
Autolysis | | 1 2.0|
Cyst | | 1 3.0|
Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Interstitial Cell, Hyperplasia | 1 1 1 1 1 2 | 39 1.2|
Seminiferous Tubule, Atrophy | 4 4 4 4 3 4 | 35 3.5|
Seminiferous Tubule, Mineralization | 1 1 1 1 | 18 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Sternal, Hypocellularity | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hemorrhage | | 1 1.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 17 |
Hemorrhage | 2 | 2 2.5|
Hyperplasia, Lymphoid | | 4 2.3|
Hyperplasia, Plasma Cell | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Abscess | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 43 1.1|
Inflammation, Chronic Active | | 10 3.1|
Pigmentation | 1 | 5 1.0|
Sinus, Ectasia | 3 4 3 3 4 2 4 3 3 3 | 56 3.4|
Sinus, Ectasia, Multiple | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Abscess | | 1 3.0|
Bacterium | | 1 4.0|
Depletion Lymphoid | 1 3 2 | 13 2.4|
Fibrosis | | 7 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 137
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 6| 5| 5| 5| | |
DAY ON TEST | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2| | |
| 9| 9| 8| 6| 1| 9| 5| 2| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + M + + + + + + + | 52 |
Autolysis | | 1 1.0|
Congestion | 4 | 1 4.0|
Cyst | | 1 4.0|
Depletion Lymphoid | 3 | 6 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + M + + + + + | 50 |
Galactocele | | 1 2.0|
Hyperplasia | 2 2 1 2 3 2 2 | 46 1.8|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
Infarct | 2 | 3 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
Bronchiectasis | 3 | 1 3.0|
Foreign Body | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 12 1.0|
Inflammation, Chronic Active | | 1 1.0|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Artery, Mineralization | 1 1 1 1 | 27 1.0|
Perivascular, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | 2 4 2 3 1 2 2 3 2 | 31 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 138
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 6| 5| 5| 5| | |
DAY ON TEST | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2| | |
| 9| 9| 8| 6| 1| 9| 5| 2| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Metaplasia, Squamous | 3 2 | 9 2.1|
Lumen, Foreign Body | 3 | 2 2.0|
Mucosa, Inflammation, Chronic Active | | 1 2.0|
Mucosa, Ulcer | 2 3 | 3 2.3|
Mucosa, Submucosa, Inflammation, | | |
Chronic Active | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 4 2.0|
Nasolacrimal Duct, Metaplasia, | | |
Squamous | | 4 2.5|
Nasopharyngeal Duct, Inflammation, | | |
Acute | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 3 |
__________________________________________________________________________|____________|
Eye | + | 9 |
Cataract | | 1 3.0|
Cornea, Neovascularization | | 1 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 2 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Abscess | | 1 3.0|
Autolysis | 2 2 | 5 2.4|
Cyst | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
Mineralization | 1 | 1 1.0|
Nephropathy | 2 2 2 2 2 2 2 2 2 | 57 1.9|
Adventitia, Inflammation, Chronic | | |
Active | 1 | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Inflammation, Acute | | 6 1.0|
Proximal Convoluted Renal Tubule, | | |
Pigmentation | 1 | 1 1.0|
Transitional Epithelium, Hyperplasia | | 5 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 139
NTP Experiment-Test: 05084-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TURMERIC, OLEORESIN (CURCUMIN) Date: 04/25/97
Route: DOSED FEED Time: 07:39:35
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 3| 7| 6| 5| 5| 5| | |
DAY ON TEST | 2| 2| 2| 5| 7| 2| 9| 2| 2| 2| | |
| 9| 9| 8| 6| 1| 9| 5| 2| 2| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
50,000 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
PPM MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 3 2.3|
Inflammation, Chronic | | 2 1.0|
Inflammation, Chronic Active | | 1 1.0|
Subserosa, Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 140
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