TDMS Study 05085-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
MANGANESE SULFATE
NTP Experiment-Test: 05085-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/11/94
Route: DOSED FEED Time: 04:58:25
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7785-87-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 19 20 19 19
Early Deaths
Natural Death 2 6 5
Moribund Sacrifice 6 4 6 4
Accidently Killed 1
Survivors
Terminal Sacrifice 42 46 38 42
Missing 1
Animals Examined Microscopically 70 61 62 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (70) (60) (59) (69)
Basophilic Focus 1 (1%) 7 (12%) 3 (5%) 5 (7%)
Clear Cell Focus 5 (8%) 2 (3%)
Congestion 1 (1%)
Cytomegaly, Multifocal 1 (1%)
Eosinophilic Focus 8 (11%) 8 (13%) 3 (5%) 4 (6%)
Hepatodiaphragmatic Nodule 2 (3%)
Infarct 1 (2%) 1 (2%)
Inflammation, Acute, Focal 2 (3%)
Inflammation, Chronic 1 (1%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (1%)
Mixed Cell Focus 3 (4%)
Vacuolization Cytoplasmic 6 (9%) 3 (5%) 7 (12%) 4 (6%)
Hepatocyte, Atrophy 1 (1%)
Kupffer Cell, Hyperplasia 1 (1%)
Mesentery (8) (3) (1)
Fat, Inflammation, Chronic Active 6 (75%) 2 (67%) 1 (100%)
Pancreas (70) (50) (50) (69)
Inflammation, Chronic Active 1 (1%)
Acinus, Atrophy 1 (1%) 4 (8%) 2 (4%)
Duct, Cyst 2 (4%) 1 (2%) 1 (1%)
Salivary Glands (70) (50) (50) (68)
Infiltration Cellular, Lymphocyte 1 (1%)
Stomach, Forestomach (70) (50) (50) (68)
Erosion, Focal 2 (3%)
Hyperplasia, Focal, Squamous 1 (1%) 3 (6%) 4 (8%) 11 (16%)
Inflammation, Chronic Active 1 (2%) 4 (6%)
Ulcer 2 (3%) 1 (2%) 3 (4%)
Stomach, Glandular (70) (50) (51) (67)
Degeneration 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 1 (1%)
Mineralization 1 (2%)
Ulcer 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (50) (50) (69)
Inflammation, Chronic Active 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (70) (50) (50) (69)
Corticomedullary Junction, Vacuolization
Cytoplasmic 1 (2%)
Adrenal Gland, Cortex (70) (50) (48) (69)
Hyperplasia 4 (6%) 7 (14%) 6 (13%) 5 (7%)
Hypertrophy 2 (3%) 4 (8%) 6 (13%) 5 (7%)
Mineralization 1 (2%)
Vacuolization Cytoplasmic 2 (3%) 1 (2%)
Adrenal Gland, Medulla (70) (50) (48) (69)
Cyst 1 (1%)
Hyperplasia 1 (1%) 2 (4%)
Islets, Pancreatic (70) (50) (50) (69)
Hyperplasia 1 (1%)
Pituitary Gland (67) (46) (50) (67)
Pars Distalis, Cyst 3 (4%) 3 (7%) 1 (2%) 1 (1%)
Pars Distalis, Hyperplasia 6 (9%) 7 (15%) 4 (8%) 10 (15%)
Thyroid Gland (69) (50) (52) (70)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic Active 1 (1%) 2 (4%) 3 (6%)
Inflammation, Granulomatous 1 (2%)
Follicle, Cyst 18 (26%) 12 (24%) 9 (17%) 7 (10%)
Follicle, Dilatation 1 (1%) 5 (10%) 12 (23%) 36 (51%)
Follicular Cell, Hyperplasia, Diffuse 1 (1%) 1 (2%)
Follicular Cell, Hyperplasia, Focal 3 (4%) 15 (30%) 27 (52%) 43 (61%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (69) (51) (53) (69)
Atrophy 2 (3%)
Fibrosis 1 (1%)
Inflammation, Chronic Active 1 (1%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Bilateral, Atrophy 1 (1%)
Bilateral, Follicle, Cyst 1 (1%) 1 (1%)
Follicle, Cyst 19 (28%) 19 (37%) 18 (34%) 14 (20%)
Periovarian Tissue, Cyst 3 (4%) 2 (4%) 3 (6%) 9 (13%)
Periovarian Tissue, Inflammation, Chronic
Active 1 (1%)
Rete Ovarii, Cyst 1 (1%)
Uterus (70) (52) (54) (69)
Hemorrhage 1 (1%)
Cervix, Inflammation, Chronic Active 1 (1%)
Endometrium, Angiectasis 1 (1%)
Endometrium, Hyperplasia, Cystic, Glandular 66 (94%) 49 (94%) 50 (93%) 66 (96%)
Endometrium, Thrombosis 1 (2%)
Lymphatic, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (50) (50) (69)
Femoral, Atrophy 1 (1%) 1 (1%)
Lymph Node (70) (50) (49) (68)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Lymph Node, Mandibular (67) (50) (47) (62)
Depletion Lymphoid 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%)
Lymph Node, Mesenteric (64) (48) (44) (59)
Inflammation, Chronic Active 1 (2%)
Spleen (70) (50) (50) (69)
Depletion Lymphoid 1 (1%) 1 (2%)
Hematopoietic Cell Proliferation 2 (3%) 3 (6%) 4 (8%) 2 (3%)
Inflammation, Chronic Active 1 (1%)
Necrosis 1 (2%)
Thrombosis 1 (1%)
Thymus (66) (49) (47) (63)
Depletion Lymphoid 3 (5%) 3 (6%) 3 (6%) 3 (5%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (62) (45) (39) (53)
Hyperplasia, Cystic 1 (2%) 1 (3%)
Skin (70) (50) (50) (69)
Abscess 1 (2%)
Acanthosis 1 (2%)
Alopecia 4 (6%) 2 (4%) 3 (6%) 3 (4%)
Ulcer 4 (8%)
Subcutaneous Tissue, Inflammation, Chronic
Active 4 (8%) 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Back, Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (50) (50) (60)
Compression 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%) 1 (2%)
Cerebellum, Cyst Epithelial Inclusion 1 (2%)
Spinal Cord (2)
Lumbar, Degeneration 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (50) (50) (69)
Inflammation, Chronic Active 2 (3%) 2 (3%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%) 1 (1%)
Perivascular, Inflammation, Chronic Active 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Inflammation, Chronic Active 1 (100%)
Harderian Gland (6) (3) (2)
Hyperplasia 3 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (50) (50) (69)
Nephropathy 41 (59%) 36 (72%) 33 (66%) 31 (45%)
Pelvis, Inflammation, Chronic Active 1 (1%)
Renal Tubule, Cytomegaly 1 (1%)
Renal Tubule, Regeneration 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 19 19
Early Deaths
Moribund Sacrifice 2 3 2 1
Natural Death 2 3 3 3
Accidently Killed 1
Survivors
Terminal Sacrifice 45 43 46 46
Moribund Sacrifice 1 1
Animals Examined Microscopically 70 60 61 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (62) (47) (50) (68)
Artery, Inflammation, Chronic Active 1 (2%)
Intestine Small, Jejunum (69) (49) (50) (69)
Diverticulum 1 (1%)
Liver (70) (59) (60) (69)
Basophilic Focus 1 (1%) 4 (7%)
Clear Cell Focus 2 (3%) 11 (19%) 6 (10%) 1 (1%)
Eosinophilic Focus 1 (1%) 6 (10%) 3 (5%) 1 (1%)
Hepatodiaphragmatic Nodule 1 (2%)
Hypertrophy 1 (1%)
Infarct 3 (4%) 2 (3%) 2 (3%) 2 (3%)
Inflammation, Chronic Active 1 (2%) 1 (1%)
Mineralization, Focal 1 (1%)
Mixed Cell Focus 1 (1%)
Necrosis 2 (3%)
Vacuolization Cytoplasmic 27 (39%) 21 (36%) 23 (38%) 24 (35%)
Bile Duct, Hyperplasia 1 (1%)
Centrilobular, Vacuolization Cytoplasmic 7 (10%) 3 (4%)
Mesentery (2) (1)
Fat, Inflammation, Chronic Active 2 (100%)
Pancreas (70) (49) (50) (69)
Acinus, Atrophy 2 (3%) 2 (4%) 3 (4%)
Duct, Cyst 2 (3%)
Stomach, Forestomach (70) (49) (51) (69)
Erosion, Focal 2 (3%)
Hyperplasia, Focal, Squamous 2 (3%) 1 (2%) 5 (10%) 14 (20%)
Inflammation, Chronic Active 5 (7%)
Ulcer 6 (9%)
Stomach, Glandular (69) (49) (51) (68)
Dysplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia 1 (2%)
Tooth (1)
Incisor, Abscess 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (70) (49) (51) (68)
Spindle Cell, Accessory Adrenal Cortical
Nodule 1 (2%)
Spindle Cell, Vacuolization Cytoplasmic 1 (1%)
Adrenal Gland, Cortex (69) (49) (51) (68)
Accessory Adrenal Cortical Nodule 1 (1%)
Atrophy 1 (1%)
Hyperplasia 3 (4%) 3 (6%) 5 (10%) 1 (1%)
Hypertrophy 27 (39%) 37 (76%) 35 (69%) 26 (38%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Gland, Medulla (69) (47) (48) (67)
Cyst 1 (1%)
Hyperplasia 1 (1%)
Islets, Pancreatic (70) (49) (50) (69)
Hyperplasia 3 (4%) 5 (10%) 2 (4%) 3 (4%)
Parathyroid Gland (65) (48) (46) (65)
Cyst 2 (4%)
Pituitary Gland (62) (44) (49) (64)
Pars Distalis, Cyst 2 (3%) 1 (2%) 2 (3%)
Pars Distalis, Hyperplasia 1 (2%)
Pars Distalis, Karyomegaly 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Pars Intermedia, Hyperplasia, Focal 1 (2%)
Rathke's Cleft, Cyst 1 (2%)
Thyroid Gland (70) (51) (52) (69)
Inflammation, Chronic Active 2 (4%) 1 (1%)
Follicle, Cyst 1 (1%) 7 (14%) 7 (13%) 5 (7%)
Follicle, Dilatation 2 (3%) 2 (4%) 5 (10%) 38 (55%)
Follicular Cell, Hyperplasia, Focal 5 (7%) 2 (4%) 8 (15%) 27 (39%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (33) (26) (20) (31)
Inflammation, Chronic Active 5 (15%) 2 (10%) 1 (3%)
Duct, Dilatation 29 (88%) 25 (96%) 18 (90%) 30 (97%)
Seminal Vesicle (60) (49) (51) (61)
Inflammation, Chronic Active 2 (4%)
Testes (70) (49) (52) (69)
Granuloma Sperm 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Seminiferous Tubule, Atrophy 1 (1%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (65) (43) (50) (65)
Depletion Lymphoid 1 (2%)
Lymph Node, Mesenteric (56) (46) (45) (63)
Hematopoietic Cell Proliferation 1 (2%) 7 (15%) 2 (4%)
Infiltration Cellular, Plasma Cell 1 (2%)
Spleen (69) (49) (50) (69)
Depletion Lymphoid 1 (1%)
Hematopoietic Cell Proliferation 4 (8%) 1 (2%) 2 (3%)
Necrosis 1 (1%)
Thymus (55) (42) (47) (59)
Depletion Lymphoid 4 (7%) 5 (12%) 4 (9%) 5 (8%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (70) (49) (51) (68)
Alopecia 1 (1%) 2 (4%) 1 (2%) 3 (4%)
Ulcer 1 (1%) 3 (6%) 3 (6%) 1 (1%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (1%) 1 (2%) 3 (6%) 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:25
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Peripheral Nerve (1)
Sciatic, Demyelination 1 (100%)
Spinal Cord (1)
Demyelination 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (49) (51) (69)
Inflammation, Chronic Active 1 (1%)
Alveolar Epithelium, Hyperplasia 4 (8%) 1 (1%)
Nose (70) (49) (51) (69)
Mucosa, Inflammation, Acute 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Inflammation, Chronic Active 1 (100%)
Harderian Gland (6) (4) (3) (5)
Hyperplasia 1 (25%) 1 (33%)
Acinus, Dilatation 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (49) (51) (69)
Hydronephrosis 1 (1%) 1 (2%)
Inflammation, Chronic Active 1 (1%)
Nephropathy 47 (67%) 48 (98%) 46 (90%) 47 (68%)
Cortex, Cyst 3 (6%)
Renal Tubule, Regeneration 10 (14%) 6 (9%)
Urinary Bladder (68) (49) (51) (68)
Lumen, Hemorrhage 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
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