Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3556

TDMS Study 05085-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         MANGANESE SULFATE


NTP Experiment-Test: 05085-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 04:58:25




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7785-87-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 19           20           19           19                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2                         6            5                                     
    Moribund Sacrifice                                 6            4            6            4                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           46           38           42                                     
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    70           61           62           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (70)         (60)         (59)         (69)                                   
      Basophilic Focus                                 1 (1%)       7 (12%)      3 (5%)       5 (7%)                                
      Clear Cell Focus                                              5 (8%)       2 (3%)                                             
      Congestion                                                                              1 (1%)                                
      Cytomegaly, Multifocal                           1 (1%)                                                                       
      Eosinophilic Focus                               8 (11%)      8 (13%)      3 (5%)       4 (6%)                                
      Hepatodiaphragmatic Nodule                                                 2 (3%)                                             
      Infarct                                                       1 (2%)       1 (2%)                                             
      Inflammation, Acute, Focal                                    2 (3%)                                                          
      Inflammation, Chronic                            1 (1%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)       1 (1%)                                
      Mixed Cell Focus                                                                        3 (4%)                                
      Vacuolization Cytoplasmic                        6 (9%)       3 (5%)       7 (12%)      4 (6%)                                
      Hepatocyte, Atrophy                              1 (1%)                                                                       
      Kupffer Cell, Hyperplasia                        1 (1%)                                                                       
   Mesentery                                          (8)          (3)          (1)                                                 
      Fat, Inflammation, Chronic Active                6 (75%)      2 (67%)      1 (100%)                                           
   Pancreas                                           (70)         (50)         (50)         (69)                                   
      Inflammation, Chronic Active                                                            1 (1%)                                
      Acinus, Atrophy                                  1 (1%)       4 (8%)       2 (4%)                                             
      Duct, Cyst                                                    2 (4%)       1 (2%)       1 (1%)                                
   Salivary Glands                                    (70)         (50)         (50)         (68)                                   
      Infiltration Cellular, Lymphocyte                1 (1%)                                                                       
   Stomach, Forestomach                               (70)         (50)         (50)         (68)                                   
      Erosion, Focal                                                                          2 (3%)                                
      Hyperplasia, Focal, Squamous                     1 (1%)       3 (6%)       4 (8%)      11 (16%)                               
      Inflammation, Chronic Active                                  1 (2%)                    4 (6%)                                
      Ulcer                                            2 (3%)                    1 (2%)       3 (4%)                                
   Stomach, Glandular                                 (70)         (50)         (51)         (67)                                   
      Degeneration                                     1 (1%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                            1 (1%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Ulcer                                                                      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (50)         (50)         (69)                                   
      Inflammation, Chronic Active                     1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (70)         (50)         (50)         (69)                                   
      Corticomedullary Junction, Vacuolization                                                                                      
          Cytoplasmic                                                            1 (2%)                                             
   Adrenal Gland, Cortex                              (70)         (50)         (48)         (69)                                   
      Hyperplasia                                      4 (6%)       7 (14%)      6 (13%)      5 (7%)                                
      Hypertrophy                                      2 (3%)       4 (8%)       6 (13%)      5 (7%)                                
      Mineralization                                                             1 (2%)                                             
      Vacuolization Cytoplasmic                        2 (3%)                    1 (2%)                                             
   Adrenal Gland, Medulla                             (70)         (50)         (48)         (69)                                   
      Cyst                                             1 (1%)                                                                       
      Hyperplasia                                      1 (1%)       2 (4%)                                                          
   Islets, Pancreatic                                 (70)         (50)         (50)         (69)                                   
      Hyperplasia                                                                             1 (1%)                                
   Pituitary Gland                                    (67)         (46)         (50)         (67)                                   
      Pars Distalis, Cyst                              3 (4%)       3 (7%)       1 (2%)       1 (1%)                                
      Pars Distalis, Hyperplasia                       6 (9%)       7 (15%)      4 (8%)      10 (15%)                               
   Thyroid Gland                                      (69)         (50)         (52)         (70)                                   
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Chronic Active                     1 (1%)       2 (4%)       3 (6%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
      Follicle, Cyst                                  18 (26%)     12 (24%)      9 (17%)      7 (10%)                               
      Follicle, Dilatation                             1 (1%)       5 (10%)     12 (23%)     36 (51%)                               
      Follicular Cell, Hyperplasia, Diffuse            1 (1%)       1 (2%)                                                          
      Follicular Cell, Hyperplasia, Focal              3 (4%)      15 (30%)     27 (52%)     43 (61%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (69)         (51)         (53)         (69)                                   
      Atrophy                                          2 (3%)                                                                       
      Fibrosis                                                                                1 (1%)                                
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Thrombosis                                                                 1 (2%)                                             
      Bilateral, Atrophy                               1 (1%)                                                                       
      Bilateral, Follicle, Cyst                        1 (1%)                                 1 (1%)                                
      Follicle, Cyst                                  19 (28%)     19 (37%)     18 (34%)     14 (20%)                               
      Periovarian Tissue, Cyst                         3 (4%)       2 (4%)       3 (6%)       9 (13%)                               
      Periovarian Tissue, Inflammation, Chronic                                                                                     
          Active                                                                              1 (1%)                                
      Rete Ovarii, Cyst                                                                       1 (1%)                                
   Uterus                                             (70)         (52)         (54)         (69)                                   
      Hemorrhage                                       1 (1%)                                                                       
      Cervix, Inflammation, Chronic Active                                                    1 (1%)                                
      Endometrium, Angiectasis                                                                1 (1%)                                
      Endometrium, Hyperplasia, Cystic, Glandular     66 (94%)     49 (94%)     50 (93%)     66 (96%)                               
      Endometrium, Thrombosis                                                    1 (2%)                                             
      Lymphatic, Cyst                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (50)         (69)                                   
      Femoral, Atrophy                                 1 (1%)                                 1 (1%)                                
   Lymph Node                                         (70)         (50)         (49)         (68)                                   
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                             1 (2%)                                             
   Lymph Node, Mandibular                             (67)         (50)         (47)         (62)                                   
      Depletion Lymphoid                                                         1 (2%)                                             
      Infiltration Cellular, Histiocyte                             2 (4%)                                                          
   Lymph Node, Mesenteric                             (64)         (48)         (44)         (59)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
   Spleen                                             (70)         (50)         (50)         (69)                                   
      Depletion Lymphoid                               1 (1%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (3%)       3 (6%)       4 (8%)       2 (3%)                                
      Inflammation, Chronic Active                                                            1 (1%)                                
      Necrosis                                                                   1 (2%)                                             
      Thrombosis                                                                              1 (1%)                                
   Thymus                                             (66)         (49)         (47)         (63)                                   
      Depletion Lymphoid                               3 (5%)       3 (6%)       3 (6%)       3 (5%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (62)         (45)         (39)         (53)                                   
      Hyperplasia, Cystic                                           1 (2%)       1 (3%)                                             
   Skin                                               (70)         (50)         (50)         (69)                                   
      Abscess                                                       1 (2%)                                                          
      Acanthosis                                                    1 (2%)                                                          
      Alopecia                                         4 (6%)       2 (4%)       3 (6%)       3 (4%)                                
      Ulcer                                                         4 (8%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                    4 (8%)                    1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Back, Inflammation, Chronic Active               1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (50)         (60)                                   
      Compression                                                                             1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hydrocephalus                                                 1 (2%)                    1 (2%)                                
      Cerebellum, Cyst Epithelial Inclusion                                      1 (2%)                                             
   Spinal Cord                                        (2)                                                                           
      Lumbar, Degeneration                             1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (50)         (50)         (69)                                   
      Inflammation, Chronic Active                     2 (3%)                                 2 (3%)                                
      Alveolar Epithelium, Hyperplasia                              1 (2%)       2 (4%)       1 (1%)                                
      Perivascular, Inflammation, Chronic Active       1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                       (1)                                    
      Cornea, Inflammation, Chronic Active                                                    1 (100%)                              
   Harderian Gland                                    (6)          (3)          (2)                                                 
      Hyperplasia                                      3 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (50)         (50)         (69)                                   
      Nephropathy                                     41 (59%)     36 (72%)     33 (66%)     31 (45%)                               
      Pelvis, Inflammation, Chronic Active                                                    1 (1%)                                
      Renal Tubule, Cytomegaly                                                                1 (1%)                                
      Renal Tubule, Regeneration                                                              1 (1%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           19           19                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            3            2            1                                     
    Natural Death                                      2            3            3            3                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           43           46           46                                     
    Moribund Sacrifice                                 1            1                                                               
  Animals Examined Microscopically                    70           60           61           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (62)         (47)         (50)         (68)                                   
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
   Intestine Small, Jejunum                           (69)         (49)         (50)         (69)                                   
      Diverticulum                                                                            1 (1%)                                
   Liver                                              (70)         (59)         (60)         (69)                                   
      Basophilic Focus                                 1 (1%)                    4 (7%)                                             
      Clear Cell Focus                                 2 (3%)      11 (19%)      6 (10%)      1 (1%)                                
      Eosinophilic Focus                               1 (1%)       6 (10%)      3 (5%)       1 (1%)                                
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Hypertrophy                                      1 (1%)                                                                       
      Infarct                                          3 (4%)       2 (3%)       2 (3%)       2 (3%)                                
      Inflammation, Chronic Active                                  1 (2%)                    1 (1%)                                
      Mineralization, Focal                                                                   1 (1%)                                
      Mixed Cell Focus                                                                        1 (1%)                                
      Necrosis                                         2 (3%)                                                                       
      Vacuolization Cytoplasmic                       27 (39%)     21 (36%)     23 (38%)     24 (35%)                               
      Bile Duct, Hyperplasia                           1 (1%)                                                                       
      Centrilobular, Vacuolization Cytoplasmic         7 (10%)                                3 (4%)                                
   Mesentery                                          (2)                       (1)                                                 
      Fat, Inflammation, Chronic Active                2 (100%)                                                                     
   Pancreas                                           (70)         (49)         (50)         (69)                                   
      Acinus, Atrophy                                  2 (3%)       2 (4%)                    3 (4%)                                
      Duct, Cyst                                       2 (3%)                                                                       
   Stomach, Forestomach                               (70)         (49)         (51)         (69)                                   
      Erosion, Focal                                                                          2 (3%)                                
      Hyperplasia, Focal, Squamous                     2 (3%)       1 (2%)       5 (10%)     14 (20%)                               
      Inflammation, Chronic Active                                                            5 (7%)                                
      Ulcer                                                                                   6 (9%)                                
   Stomach, Glandular                                 (69)         (49)         (51)         (68)                                   
      Dysplasia                                                                  1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia                                                   1 (2%)                                                          
   Tooth                                                                        (1)                                                 
      Incisor, Abscess                                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (70)         (49)         (51)         (68)                                   
      Spindle Cell, Accessory Adrenal Cortical                                                                                      
          Nodule                                                                 1 (2%)                                             
      Spindle Cell, Vacuolization Cytoplasmic          1 (1%)                                                                       
   Adrenal Gland, Cortex                              (69)         (49)         (51)         (68)                                   
      Accessory Adrenal Cortical Nodule                1 (1%)                                                                       
      Atrophy                                          1 (1%)                                                                       
      Hyperplasia                                      3 (4%)       3 (6%)       5 (10%)      1 (1%)                                
      Hypertrophy                                     27 (39%)     37 (76%)     35 (69%)     26 (38%)                               
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
   Adrenal Gland, Medulla                             (69)         (47)         (48)         (67)                                   
      Cyst                                                                                    1 (1%)                                
      Hyperplasia                                      1 (1%)                                                                       
   Islets, Pancreatic                                 (70)         (49)         (50)         (69)                                   
      Hyperplasia                                      3 (4%)       5 (10%)      2 (4%)       3 (4%)                                
   Parathyroid Gland                                  (65)         (48)         (46)         (65)                                   
      Cyst                                                          2 (4%)                                                          
   Pituitary Gland                                    (62)         (44)         (49)         (64)                                   
      Pars Distalis, Cyst                              2 (3%)       1 (2%)                    2 (3%)                                
      Pars Distalis, Hyperplasia                                                              1 (2%)                                
      Pars Distalis, Karyomegaly                                                              1 (2%)                                
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
      Pars Intermedia, Hyperplasia, Focal                                        1 (2%)                                             
      Rathke's Cleft, Cyst                                                       1 (2%)                                             
   Thyroid Gland                                      (70)         (51)         (52)         (69)                                   
      Inflammation, Chronic Active                                               2 (4%)       1 (1%)                                
      Follicle, Cyst                                   1 (1%)       7 (14%)      7 (13%)      5 (7%)                                
      Follicle, Dilatation                             2 (3%)       2 (4%)       5 (10%)     38 (55%)                               
      Follicular Cell, Hyperplasia, Focal              5 (7%)       2 (4%)       8 (15%)     27 (39%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (33)         (26)         (20)         (31)                                   
      Inflammation, Chronic Active                     5 (15%)                   2 (10%)      1 (3%)                                
      Duct, Dilatation                                29 (88%)     25 (96%)     18 (90%)     30 (97%)                               
   Seminal Vesicle                                    (60)         (49)         (51)         (61)                                   
      Inflammation, Chronic Active                                  2 (4%)                                                          
   Testes                                             (70)         (49)         (52)         (69)                                   
      Granuloma Sperm                                                            1 (2%)                                             
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
      Seminiferous Tubule, Atrophy                     1 (1%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (65)         (43)         (50)         (65)                                   
      Depletion Lymphoid                               1 (2%)                                                                       
   Lymph Node, Mesenteric                             (56)         (46)         (45)         (63)                                   
      Hematopoietic Cell Proliferation                 1 (2%)       7 (15%)      2 (4%)                                             
      Infiltration Cellular, Plasma Cell               1 (2%)                                                                       
   Spleen                                             (69)         (49)         (50)         (69)                                   
      Depletion Lymphoid                               1 (1%)                                                                       
      Hematopoietic Cell Proliferation                              4 (8%)       1 (2%)       2 (3%)                                
      Necrosis                                         1 (1%)                                                                       
   Thymus                                             (55)         (42)         (47)         (59)                                   
      Depletion Lymphoid                               4 (7%)       5 (12%)      4 (9%)       5 (8%)                                
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (70)         (49)         (51)         (68)                                   
      Alopecia                                         1 (1%)       2 (4%)       1 (2%)       3 (4%)                                
      Ulcer                                            1 (1%)       3 (6%)       3 (6%)       1 (1%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       1 (1%)       1 (2%)       3 (6%)       1 (1%)                                
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05085-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                   (1)                                                                           
      Sciatic, Demyelination                           1 (100%)                                                                     
   Spinal Cord                                        (1)                                                                           
      Demyelination                                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (49)         (51)         (69)                                   
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Alveolar Epithelium, Hyperplasia                                           4 (8%)       1 (1%)                                
   Nose                                               (70)         (49)         (51)         (69)                                   
      Mucosa, Inflammation, Acute                      1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Cornea, Inflammation, Chronic Active                                       1 (100%)                                           
   Harderian Gland                                    (6)          (4)          (3)          (5)                                    
      Hyperplasia                                                   1 (25%)      1 (33%)                                            
      Acinus, Dilatation                                            1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (49)         (51)         (69)                                   
      Hydronephrosis                                   1 (1%)       1 (2%)                                                          
      Inflammation, Chronic Active                                                            1 (1%)                                
      Nephropathy                                     47 (67%)     48 (98%)     46 (90%)     47 (68%)                               
      Cortex, Cyst                                                  3 (6%)                                                          
      Renal Tubule, Regeneration                      10 (14%)                                6 (9%)                                
   Urinary Bladder                                    (68)         (49)         (51)         (68)                                   
      Lumen, Hemorrhage                                                                       1 (1%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------