https://ntp.niehs.nih.gov/go/3560

TDMS Study 05085-02 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         MANGANESE SULFATE
NTP Experiment-Test: 05085-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 04:58:27
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  7785-87-7
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                             Page   1
NTP Experiment-Test: 05085-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 19           20           19           19                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2                         6            5                                     
    Moribund Sacrifice                                 6            4            6            4                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                42           46           38           42                                     
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    70           61           62           70                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Cecum                             (70)         (50)         (49)         (69)                                   
   Intestine Small, Duodenum                          (70)         (49)         (50)         (68)                                   
      Adenocarcinoma                                                                          1 (1%)                                
   Intestine Small, Jejunum                           (70)         (50)         (50)         (69)                                   
   Liver                                              (70)         (60)         (59)         (69)                                   
      Hemangiosarcoma                                  1 (1%)                                                                       
      Hepatocellular Carcinoma                         3 (4%)       1 (2%)       1 (2%)       2 (3%)                                
      Hepatocellular Adenoma                          11 (16%)     11 (18%)      8 (14%)      9 (13%)                               
      Hepatocellular Adenoma, Multiple                 1 (1%)       3 (5%)                    3 (4%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)       1 (1%)                                
   Mesentery                                          (8)          (3)          (1)                                                 
      Fibrosarcoma, Metastatic                         1 (13%)                                                                      
   Pancreas                                           (70)         (50)         (50)         (69)                                   
      Fibrosarcoma, Metastatic, Skin                   1 (1%)                                                                       
   Salivary Glands                                    (70)         (50)         (50)         (68)                                   
      Neurofibrosarcoma, Metastatic, Skin                                        1 (2%)                                             
   Stomach, Forestomach                               (70)         (50)         (50)         (68)                                   
      Squamous Cell Papilloma                          1 (1%)                                                                       
   Stomach, Glandular                                 (70)         (50)         (51)         (67)                                   
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                             Page   2                                                               
NTP Experiment-Test: 05085-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Gland                                      (70)         (50)         (50)         (69)                                   
      Spindle Cell, Adenoma                                         2 (4%)       3 (6%)                                             
   Adrenal Gland, Cortex                              (70)         (50)         (48)         (69)                                   
   Adrenal Gland, Medulla                             (70)         (50)         (48)         (69)                                   
      Pheochromocytoma Benign                          1 (1%)       1 (2%)                    1 (1%)                                
   Pituitary Gland                                    (67)         (46)         (50)         (67)                                   
      Pars Distalis, Adenoma                           2 (3%)       3 (7%)       6 (12%)      5 (7%)                                
      Pars Intermedia, Adenoma                                                   2 (4%)       1 (1%)                                
   Thyroid Gland                                      (69)         (50)         (52)         (70)                                   
      C-Cell, Carcinoma                                                                       1 (1%)                                
      Follicular Cell, Adenoma                         2 (3%)       1 (2%)                    5 (7%)                                
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (69)         (51)         (53)         (69)                                   
      Adenoma                                                       2 (4%)                                                          
      Cystadenoma                                      1 (1%)                    1 (2%)       2 (3%)                                
      Cystadenoma, Papillary                           1 (1%)                                                                       
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
      Teratoma Malignant                                                                      1 (1%)                                
      Bilateral, Adenocarcinoma, Metastatic                         1 (2%)                                                          
   Uterus                                             (70)         (52)         (54)         (69)                                   
      Adenocarcinoma                                                2 (4%)                                                          
      Hemangioma                                       1 (1%)                                                                       
      Hemangiosarcoma                                  1 (1%)                                 1 (1%)                                
      Polyp Stromal                                    1 (1%)       1 (2%)                    2 (3%)                                
      Sarcoma Stromal                                               1 (2%)                                                          
      Cervix, Leiomyoma                                1 (1%)                                                                       
      Cervix, Osteosarcoma, Metastatic, Bone                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (70)         (50)         (50)         (69)                                   
      Femoral, Hemangiosarcoma                                      3 (6%)                                                          
   Lymph Node                                         (70)         (50)         (49)         (68)                                   
   Lymph Node, Mandibular                             (67)         (50)         (47)         (62)                                   
   Lymph Node, Mesenteric                             (64)         (48)         (44)         (59)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
   Spleen                                             (70)         (50)         (50)         (69)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05085-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Fibrosarcoma                                     1 (1%)                                                                       
      Hemangiosarcoma                                               2 (4%)                    2 (3%)                                
   Thymus                                             (66)         (49)         (47)         (63)                                   
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (70)         (50)         (50)         (69)                                   
      Subcutaneous Tissue, Fibrosarcoma                2 (3%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Neurofibrosarcoma           1 (1%)                    3 (6%)                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (70)         (50)         (50)         (69)                                   
      Femur, Osteosarcoma                                                                     2 (3%)                                
      Pelvis, Osteosarcoma                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (70)         (50)         (50)         (69)                                   
      Alveolar/Bronchiolar Adenoma                     2 (3%)       4 (8%)       3 (6%)       4 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   4 (6%)                    3 (6%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (1%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (1%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)       1 (1%)                                
      Teratoma Malignant, Metastatic, Ovary                                                   1 (1%)                                
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (6)          (3)          (2)                                                 
      Adenocarcinoma                                   1 (17%)                                                                      
      Adenoma                                          2 (33%)      3 (100%)     2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05085-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (70)         (50)         (50)         (69)                                   
   Urinary Bladder                                    (70)         (50)         (49)         (68)                                   
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(61)        *(62)        *(70)                                   
      Lymphoma Malignant Histiocytic                   4 (6%)       3 (5%)       5 (8%)       2 (3%)                                
      Lymphoma Malignant Lymphocytic                   4 (6%)       4 (7%)       4 (6%)       2 (3%)                                
      Lymphoma Malignant Mixed                         7 (10%)     10 (16%)     12 (19%)      9 (13%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05085-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            37          37          39          36                                       
     Total Primary Neoplasms                           57          59          54          56                                       
   Total Animals with Benign Neoplasms                 21          24          18          25                                       
     Total Benign Neoplasms                            28          32          25          32                                       
   Total Animals with Malignant Neoplasms              23          23          26          21                                       
     Total Malignant Neoplasms                         29          27          29          24                                       
   Total Animals with Metastatic Neoplasms              1           1           2           3                                       
     Total Metastatic Neoplasm                          3           1           5           4                                       
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05085-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           19           19                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            3            2            1                                     
    Natural Death                                      2            3            3            3                                     
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                45           43           46           46                                     
    Moribund Sacrifice                                 1            1                                                               
  Animals Examined Microscopically                    70           60           61           70                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Cecum                             (67)         (49)         (49)         (69)                                   
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small                                    (70)         (50)         (50)         (69)                                   
   Intestine Small, Duodenum                          (68)         (50)         (50)         (69)                                   
      Polyp Adenomatous                                1 (1%)       1 (2%)       1 (2%)                                             
   Intestine Small, Jejunum                           (69)         (49)         (50)         (69)                                   
      Adenocarcinoma                                                2 (4%)                                                          
   Liver                                              (70)         (59)         (60)         (69)                                   
      Hemangiosarcoma                                  1 (1%)                    1 (2%)       1 (1%)                                
      Hepatocellular Carcinoma                         5 (7%)      10 (17%)      6 (10%)      4 (6%)                                
      Hepatocellular Carcinoma, Multiple               4 (6%)       2 (3%)       2 (3%)       2 (3%)                                
      Hepatocellular Adenoma                          15 (21%)     12 (20%)      5 (8%)      12 (17%)                               
      Hepatocellular Adenoma, Multiple                16 (23%)     17 (29%)     14 (23%)      9 (13%)                               
      Sarcoma                                          1 (1%)                                                                       
   Mesentery                                          (2)                       (1)                                                 
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (100%)                                           
   Pancreas                                           (70)         (49)         (50)         (69)                                   
   Stomach, Forestomach                               (70)         (49)         (51)         (69)                                   
      Squamous Cell Papilloma                          1 (1%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (70)         (49)         (51)         (70)                                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05085-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Gland                                      (70)         (49)         (51)         (68)                                   
      Spindle Cell, Adenoma                           10 (14%)      5 (10%)      7 (14%)     14 (21%)                               
   Adrenal Gland, Cortex                              (69)         (49)         (51)         (68)                                   
      Adenoma                                                       3 (6%)       1 (2%)       1 (1%)                                
   Adrenal Gland, Medulla                             (69)         (47)         (48)         (67)                                   
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (70)         (49)         (50)         (69)                                   
      Adenoma                                                                    2 (4%)                                             
   Thyroid Gland                                      (70)         (51)         (52)         (69)                                   
      Follicular Cell, Adenoma                                                                4 (6%)                                
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (70)         (49)         (51)         (69)                                   
      Fibrosarcoma                                                               1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)                                                          
   Prostate                                           (70)         (49)         (51)         (69)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Testes                                             (70)         (49)         (52)         (69)                                   
      Interstitial Cell, Carcinoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (70)         (49)         (51)         (69)                                   
      Femoral, Hemangiosarcoma                                      1 (2%)                                                          
   Lymph Node                                         (67)         (49)         (51)         (69)                                   
      Bronchial, Hepatocholangiocarcinoma,                                                                                          
          Metastatic, Liver                            1 (1%)                                                                       
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                         1 (2%)                                                          
      Thoracic, Hepatocholangiocarcinoma,                                                                                           
          Metastatic, Liver                            1 (1%)                                                                       
   Lymph Node, Mandibular                             (65)         (43)         (50)         (65)                                   
   Lymph Node, Mesenteric                             (56)         (46)         (45)         (63)                                   
   Spleen                                             (69)         (49)         (50)         (69)                                   
      Fibrosarcoma                                                  2 (4%)                                                          
      Hemangiosarcoma                                               1 (2%)       2 (4%)                                             
   Thymus                                             (55)         (42)         (47)         (59)                                   
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05085-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (70)         (49)         (51)         (68)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (70)         (49)         (51)         (70)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (70)         (49)         (51)         (69)                                   
      Alveolar/Bronchiolar Adenoma                     7 (10%)      9 (18%)      5 (10%)      8 (12%)                               
      Alveolar/Bronchiolar Adenoma, Multiple           1 (1%)       1 (2%)                    1 (1%)                                
      Alveolar/Bronchiolar Carcinoma                   5 (7%)       4 (8%)       4 (8%)       4 (6%)                                
      Carcinoma, Metastatic, Testes                                              1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                   4 (8%)       3 (6%)       2 (3%)                                
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Ear                                                             (1)                       (2)                                    
      Pinna, Fibroma                                                1 (100%)                  1 (50%)                               
   Harderian Gland                                    (6)          (4)          (3)          (5)                                    
      Adenocarcinoma                                   1 (17%)                                4 (80%)                               
      Adenoma                                          5 (83%)      2 (50%)      2 (67%)      1 (20%)                               
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (70)         (49)         (51)         (69)                                   
      Carcinoma, Metastatic, Testes                                              1 (2%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (1%)                                                                       
                                                             Page   9                                                               
NTP Experiment-Test: 05085-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(70)        *(60)        *(61)        *(70)                                   
      Lymphoma Malignant Histiocytic                   1 (1%)                                                                       
      Lymphoma Malignant Lymphocytic                                1 (2%)       2 (3%)                                             
      Lymphoma Malignant Mixed                         4 (6%)       2 (3%)       3 (5%)       2 (3%)                                
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05085-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 04:58:27  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            49          45          40          41                                       
     Total Primary Neoplasms                           78          81          62          68                                       
   Total Animals with Benign Neoplasms                 41          40          31          34                                       
     Total Benign Neoplasms                            56          52          39          51                                       
   Total Animals with Malignant Neoplasms              20          24          21          15                                       
     Total Malignant Neoplasms                         22          29          23          17                                       
   Total Animals with Metastatic Neoplasms              1           4           4           2                                       
     Total Metastatic Neoplasm                          5           5           6           2                                       
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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