TDMS Study 05085-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) MANGANESE SULFATE NTP Experiment-Test: 05085-02 Report: PEIRPT05 Study Type: CHRONIC Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 Facility: Battelle Columbus Laboratory Chemical CAS #: 7785-87-7 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 70 70 70 70 Scheduled Sacrifice 19 20 19 19 Early Deaths Natural Death 2 6 5 Moribund Sacrifice 6 4 6 4 Accidently Killed 1 Survivors Terminal Sacrifice 42 46 38 42 Missing 1 Animals Examined Microscopically 70 61 62 70 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (70) (50) (49) (69) Intestine Small, Duodenum (70) (49) (50) (68) Adenocarcinoma 1 (1%) Intestine Small, Jejunum (70) (50) (50) (69) Liver (70) (60) (59) (69) Hemangiosarcoma 1 (1%) Hepatocellular Carcinoma 3 (4%) 1 (2%) 1 (2%) 2 (3%) Hepatocellular Adenoma 11 (16%) 11 (18%) 8 (14%) 9 (13%) Hepatocellular Adenoma, Multiple 1 (1%) 3 (5%) 3 (4%) Osteosarcoma, Metastatic, Bone 1 (2%) 1 (1%) Mesentery (8) (3) (1) Fibrosarcoma, Metastatic 1 (13%) Pancreas (70) (50) (50) (69) Fibrosarcoma, Metastatic, Skin 1 (1%) Salivary Glands (70) (50) (50) (68) Neurofibrosarcoma, Metastatic, Skin 1 (2%) Stomach, Forestomach (70) (50) (50) (68) Squamous Cell Papilloma 1 (1%) Stomach, Glandular (70) (50) (51) (67) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (70) (50) (50) (69) Spindle Cell, Adenoma 2 (4%) 3 (6%) Adrenal Gland, Cortex (70) (50) (48) (69) Adrenal Gland, Medulla (70) (50) (48) (69) Pheochromocytoma Benign 1 (1%) 1 (2%) 1 (1%) Pituitary Gland (67) (46) (50) (67) Pars Distalis, Adenoma 2 (3%) 3 (7%) 6 (12%) 5 (7%) Pars Intermedia, Adenoma 2 (4%) 1 (1%) Thyroid Gland (69) (50) (52) (70) C-Cell, Carcinoma 1 (1%) Follicular Cell, Adenoma 2 (3%) 1 (2%) 5 (7%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (69) (51) (53) (69) Adenoma 2 (4%) Cystadenoma 1 (1%) 1 (2%) 2 (3%) Cystadenoma, Papillary 1 (1%) Granulosa Cell Tumor Benign 1 (2%) Teratoma Malignant 1 (1%) Bilateral, Adenocarcinoma, Metastatic 1 (2%) Uterus (70) (52) (54) (69) Adenocarcinoma 2 (4%) Hemangioma 1 (1%) Hemangiosarcoma 1 (1%) 1 (1%) Polyp Stromal 1 (1%) 1 (2%) 2 (3%) Sarcoma Stromal 1 (2%) Cervix, Leiomyoma 1 (1%) Cervix, Osteosarcoma, Metastatic, Bone 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (70) (50) (50) (69) Femoral, Hemangiosarcoma 3 (6%) Lymph Node (70) (50) (49) (68) Lymph Node, Mandibular (67) (50) (47) (62) Lymph Node, Mesenteric (64) (48) (44) (59) Hemangiosarcoma 1 (2%) Spleen (70) (50) (50) (69) Page 3 NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Fibrosarcoma 1 (1%) Hemangiosarcoma 2 (4%) 2 (3%) Thymus (66) (49) (47) (63) Thymoma Benign 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (70) (50) (50) (69) Subcutaneous Tissue, Fibrosarcoma 2 (3%) Subcutaneous Tissue, Hemangiosarcoma 1 (2%) Subcutaneous Tissue, Neurofibrosarcoma 1 (1%) 3 (6%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (70) (50) (50) (69) Femur, Osteosarcoma 2 (3%) Pelvis, Osteosarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (70) (50) (50) (69) Alveolar/Bronchiolar Adenoma 2 (3%) 4 (8%) 3 (6%) 4 (6%) Alveolar/Bronchiolar Carcinoma 4 (6%) 3 (6%) Fibrosarcoma, Metastatic, Skin 1 (1%) Hepatocellular Carcinoma, Metastatic, Liver 1 (1%) Osteosarcoma, Metastatic, Bone 1 (2%) 1 (1%) Teratoma Malignant, Metastatic, Ovary 1 (1%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (6) (3) (2) Adenocarcinoma 1 (17%) Adenoma 2 (33%) 3 (100%) 2 (100%) ____________________________________________________________________________________________________________________________________ Page 4 NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (70) (50) (50) (69) Urinary Bladder (70) (50) (49) (68) Osteosarcoma, Metastatic, Bone 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(70) *(61) *(62) *(70) Lymphoma Malignant Histiocytic 4 (6%) 3 (5%) 5 (8%) 2 (3%) Lymphoma Malignant Lymphocytic 4 (6%) 4 (7%) 4 (6%) 2 (3%) Lymphoma Malignant Mixed 7 (10%) 10 (16%) 12 (19%) 9 (13%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 5 NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 37 37 39 36 Total Primary Neoplasms 57 59 54 56 Total Animals with Benign Neoplasms 21 24 18 25 Total Benign Neoplasms 28 32 25 32 Total Animals with Malignant Neoplasms 23 23 26 21 Total Malignant Neoplasms 29 27 29 24 Total Animals with Metastatic Neoplasms 1 1 2 3 Total Metastatic Neoplasm 3 1 5 4 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 6 NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 70 70 70 70 Scheduled Sacrifice 20 20 19 19 Early Deaths Moribund Sacrifice 2 3 2 1 Natural Death 2 3 3 3 Accidently Killed 1 Survivors Terminal Sacrifice 45 43 46 46 Moribund Sacrifice 1 1 Animals Examined Microscopically 70 60 61 70 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Cecum (67) (49) (49) (69) Adenocarcinoma 1 (2%) Intestine Small (70) (50) (50) (69) Intestine Small, Duodenum (68) (50) (50) (69) Polyp Adenomatous 1 (1%) 1 (2%) 1 (2%) Intestine Small, Jejunum (69) (49) (50) (69) Adenocarcinoma 2 (4%) Liver (70) (59) (60) (69) Hemangiosarcoma 1 (1%) 1 (2%) 1 (1%) Hepatocellular Carcinoma 5 (7%) 10 (17%) 6 (10%) 4 (6%) Hepatocellular Carcinoma, Multiple 4 (6%) 2 (3%) 2 (3%) 2 (3%) Hepatocellular Adenoma 15 (21%) 12 (20%) 5 (8%) 12 (17%) Hepatocellular Adenoma, Multiple 16 (23%) 17 (29%) 14 (23%) 9 (13%) Sarcoma 1 (1%) Mesentery (2) (1) Hepatocellular Carcinoma, Metastatic, Liver 1 (100%) Pancreas (70) (49) (50) (69) Stomach, Forestomach (70) (49) (51) (69) Squamous Cell Papilloma 1 (1%) 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (70) (49) (51) (70) Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Gland (70) (49) (51) (68) Spindle Cell, Adenoma 10 (14%) 5 (10%) 7 (14%) 14 (21%) Adrenal Gland, Cortex (69) (49) (51) (68) Adenoma 3 (6%) 1 (2%) 1 (1%) Adrenal Gland, Medulla (69) (47) (48) (67) Pheochromocytoma Benign 1 (2%) Islets, Pancreatic (70) (49) (50) (69) Adenoma 2 (4%) Thyroid Gland (70) (51) (52) (69) Follicular Cell, Adenoma 4 (6%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (70) (49) (51) (69) Fibrosarcoma 1 (2%) Hemangiosarcoma 1 (2%) Prostate (70) (49) (51) (69) Hemangiosarcoma 1 (2%) Testes (70) (49) (52) (69) Interstitial Cell, Carcinoma 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (70) (49) (51) (69) Femoral, Hemangiosarcoma 1 (2%) Lymph Node (67) (49) (51) (69) Bronchial, Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) Mediastinal, Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) Thoracic, Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) Lymph Node, Mandibular (65) (43) (50) (65) Lymph Node, Mesenteric (56) (46) (45) (63) Spleen (69) (49) (50) (69) Fibrosarcoma 2 (4%) Hemangiosarcoma 1 (2%) 2 (4%) Thymus (55) (42) (47) (59) ____________________________________________________________________________________________________________________________________ Page 8 NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000 PPM ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (70) (49) (51) (68) Squamous Cell Papilloma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (70) (49) (51) (70) Hemangiosarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (70) (49) (51) (69) Alveolar/Bronchiolar Adenoma 7 (10%) 9 (18%) 5 (10%) 8 (12%) Alveolar/Bronchiolar Adenoma, Multiple 1 (1%) 1 (2%) 1 (1%) Alveolar/Bronchiolar Carcinoma 5 (7%) 4 (8%) 4 (8%) 4 (6%) Carcinoma, Metastatic, Testes 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 4 (8%) 3 (6%) 2 (3%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Ear (1) (2) Pinna, Fibroma 1 (100%) 1 (50%) Harderian Gland (6) (4) (3) (5) Adenocarcinoma 1 (17%) 4 (80%) Adenoma 5 (83%) 2 (50%) 2 (67%) 1 (20%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (70) (49) (51) (69) Carcinoma, Metastatic, Testes 1 (2%) Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%) Page 9 NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000 PPM ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(70) *(60) *(61) *(70) Lymphoma Malignant Histiocytic 1 (1%) Lymphoma Malignant Lymphocytic 1 (2%) 2 (3%) Lymphoma Malignant Mixed 4 (6%) 2 (3%) 3 (5%) 2 (3%) Lymphoma Malignant Undifferentiated Cell 1 (2%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 10 NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94 Route: DOSED FEED Time: 04:58:27 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000 PPM ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 49 45 40 41 Total Primary Neoplasms 78 81 62 68 Total Animals with Benign Neoplasms 41 40 31 34 Total Benign Neoplasms 56 52 39 51 Total Animals with Malignant Neoplasms 20 24 21 15 Total Malignant Neoplasms 22 29 23 17 Total Animals with Metastatic Neoplasms 1 4 4 2 Total Metastatic Neoplasm 5 5 6 2 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------