TDMS Study 05085-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
MANGANESE SULFATE
NTP Experiment-Test: 05085-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7785-87-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Scheduled Sacrifice 19 20 19 19
Early Deaths
Natural Death 2 6 5
Moribund Sacrifice 6 4 6 4
Accidently Killed 1
Survivors
Terminal Sacrifice 42 46 38 42
Missing 1
Animals Examined Microscopically 70 61 62 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (70) (50) (49) (69)
Intestine Small, Duodenum (70) (49) (50) (68)
Adenocarcinoma 1 (1%)
Intestine Small, Jejunum (70) (50) (50) (69)
Liver (70) (60) (59) (69)
Hemangiosarcoma 1 (1%)
Hepatocellular Carcinoma 3 (4%) 1 (2%) 1 (2%) 2 (3%)
Hepatocellular Adenoma 11 (16%) 11 (18%) 8 (14%) 9 (13%)
Hepatocellular Adenoma, Multiple 1 (1%) 3 (5%) 3 (4%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (1%)
Mesentery (8) (3) (1)
Fibrosarcoma, Metastatic 1 (13%)
Pancreas (70) (50) (50) (69)
Fibrosarcoma, Metastatic, Skin 1 (1%)
Salivary Glands (70) (50) (50) (68)
Neurofibrosarcoma, Metastatic, Skin 1 (2%)
Stomach, Forestomach (70) (50) (50) (68)
Squamous Cell Papilloma 1 (1%)
Stomach, Glandular (70) (50) (51) (67)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (70) (50) (50) (69)
Spindle Cell, Adenoma 2 (4%) 3 (6%)
Adrenal Gland, Cortex (70) (50) (48) (69)
Adrenal Gland, Medulla (70) (50) (48) (69)
Pheochromocytoma Benign 1 (1%) 1 (2%) 1 (1%)
Pituitary Gland (67) (46) (50) (67)
Pars Distalis, Adenoma 2 (3%) 3 (7%) 6 (12%) 5 (7%)
Pars Intermedia, Adenoma 2 (4%) 1 (1%)
Thyroid Gland (69) (50) (52) (70)
C-Cell, Carcinoma 1 (1%)
Follicular Cell, Adenoma 2 (3%) 1 (2%) 5 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (69) (51) (53) (69)
Adenoma 2 (4%)
Cystadenoma 1 (1%) 1 (2%) 2 (3%)
Cystadenoma, Papillary 1 (1%)
Granulosa Cell Tumor Benign 1 (2%)
Teratoma Malignant 1 (1%)
Bilateral, Adenocarcinoma, Metastatic 1 (2%)
Uterus (70) (52) (54) (69)
Adenocarcinoma 2 (4%)
Hemangioma 1 (1%)
Hemangiosarcoma 1 (1%) 1 (1%)
Polyp Stromal 1 (1%) 1 (2%) 2 (3%)
Sarcoma Stromal 1 (2%)
Cervix, Leiomyoma 1 (1%)
Cervix, Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (50) (50) (69)
Femoral, Hemangiosarcoma 3 (6%)
Lymph Node (70) (50) (49) (68)
Lymph Node, Mandibular (67) (50) (47) (62)
Lymph Node, Mesenteric (64) (48) (44) (59)
Hemangiosarcoma 1 (2%)
Spleen (70) (50) (50) (69)
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NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Fibrosarcoma 1 (1%)
Hemangiosarcoma 2 (4%) 2 (3%)
Thymus (66) (49) (47) (63)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (70) (50) (50) (69)
Subcutaneous Tissue, Fibrosarcoma 2 (3%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (1%) 3 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (50) (50) (69)
Femur, Osteosarcoma 2 (3%)
Pelvis, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (50) (50) (69)
Alveolar/Bronchiolar Adenoma 2 (3%) 4 (8%) 3 (6%) 4 (6%)
Alveolar/Bronchiolar Carcinoma 4 (6%) 3 (6%)
Fibrosarcoma, Metastatic, Skin 1 (1%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (1%)
Osteosarcoma, Metastatic, Bone 1 (2%) 1 (1%)
Teratoma Malignant, Metastatic, Ovary 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (6) (3) (2)
Adenocarcinoma 1 (17%)
Adenoma 2 (33%) 3 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (50) (50) (69)
Urinary Bladder (70) (50) (49) (68)
Osteosarcoma, Metastatic, Bone 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(61) *(62) *(70)
Lymphoma Malignant Histiocytic 4 (6%) 3 (5%) 5 (8%) 2 (3%)
Lymphoma Malignant Lymphocytic 4 (6%) 4 (7%) 4 (6%) 2 (3%)
Lymphoma Malignant Mixed 7 (10%) 10 (16%) 12 (19%) 9 (13%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 37 37 39 36
Total Primary Neoplasms 57 59 54 56
Total Animals with Benign Neoplasms 21 24 18 25
Total Benign Neoplasms 28 32 25 32
Total Animals with Malignant Neoplasms 23 23 26 21
Total Malignant Neoplasms 29 27 29 24
Total Animals with Metastatic Neoplasms 1 1 2 3
Total Metastatic Neoplasm 3 1 5 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Scheduled Sacrifice 20 20 19 19
Early Deaths
Moribund Sacrifice 2 3 2 1
Natural Death 2 3 3 3
Accidently Killed 1
Survivors
Terminal Sacrifice 45 43 46 46
Moribund Sacrifice 1 1
Animals Examined Microscopically 70 60 61 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (67) (49) (49) (69)
Adenocarcinoma 1 (2%)
Intestine Small (70) (50) (50) (69)
Intestine Small, Duodenum (68) (50) (50) (69)
Polyp Adenomatous 1 (1%) 1 (2%) 1 (2%)
Intestine Small, Jejunum (69) (49) (50) (69)
Adenocarcinoma 2 (4%)
Liver (70) (59) (60) (69)
Hemangiosarcoma 1 (1%) 1 (2%) 1 (1%)
Hepatocellular Carcinoma 5 (7%) 10 (17%) 6 (10%) 4 (6%)
Hepatocellular Carcinoma, Multiple 4 (6%) 2 (3%) 2 (3%) 2 (3%)
Hepatocellular Adenoma 15 (21%) 12 (20%) 5 (8%) 12 (17%)
Hepatocellular Adenoma, Multiple 16 (23%) 17 (29%) 14 (23%) 9 (13%)
Sarcoma 1 (1%)
Mesentery (2) (1)
Hepatocellular Carcinoma, Metastatic, Liver 1 (100%)
Pancreas (70) (49) (50) (69)
Stomach, Forestomach (70) (49) (51) (69)
Squamous Cell Papilloma 1 (1%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (49) (51) (70)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (70) (49) (51) (68)
Spindle Cell, Adenoma 10 (14%) 5 (10%) 7 (14%) 14 (21%)
Adrenal Gland, Cortex (69) (49) (51) (68)
Adenoma 3 (6%) 1 (2%) 1 (1%)
Adrenal Gland, Medulla (69) (47) (48) (67)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (70) (49) (50) (69)
Adenoma 2 (4%)
Thyroid Gland (70) (51) (52) (69)
Follicular Cell, Adenoma 4 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (70) (49) (51) (69)
Fibrosarcoma 1 (2%)
Hemangiosarcoma 1 (2%)
Prostate (70) (49) (51) (69)
Hemangiosarcoma 1 (2%)
Testes (70) (49) (52) (69)
Interstitial Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (49) (51) (69)
Femoral, Hemangiosarcoma 1 (2%)
Lymph Node (67) (49) (51) (69)
Bronchial, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (1%)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (2%)
Thoracic, Hepatocholangiocarcinoma,
Metastatic, Liver 1 (1%)
Lymph Node, Mandibular (65) (43) (50) (65)
Lymph Node, Mesenteric (56) (46) (45) (63)
Spleen (69) (49) (50) (69)
Fibrosarcoma 2 (4%)
Hemangiosarcoma 1 (2%) 2 (4%)
Thymus (55) (42) (47) (59)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (70) (49) (51) (68)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (49) (51) (70)
Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (49) (51) (69)
Alveolar/Bronchiolar Adenoma 7 (10%) 9 (18%) 5 (10%) 8 (12%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (1%) 1 (2%) 1 (1%)
Alveolar/Bronchiolar Carcinoma 5 (7%) 4 (8%) 4 (8%) 4 (6%)
Carcinoma, Metastatic, Testes 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 4 (8%) 3 (6%) 2 (3%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2)
Pinna, Fibroma 1 (100%) 1 (50%)
Harderian Gland (6) (4) (3) (5)
Adenocarcinoma 1 (17%) 4 (80%)
Adenoma 5 (83%) 2 (50%) 2 (67%) 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (49) (51) (69)
Carcinoma, Metastatic, Testes 1 (2%)
Hepatocholangiocarcinoma, Metastatic, Liver 1 (1%)
Page 9
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(60) *(61) *(70)
Lymphoma Malignant Histiocytic 1 (1%)
Lymphoma Malignant Lymphocytic 1 (2%) 2 (3%)
Lymphoma Malignant Mixed 4 (6%) 2 (3%) 3 (5%) 2 (3%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05085-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 04:58:27
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 45 40 41
Total Primary Neoplasms 78 81 62 68
Total Animals with Benign Neoplasms 41 40 31 34
Total Benign Neoplasms 56 52 39 51
Total Animals with Malignant Neoplasms 20 24 21 15
Total Malignant Neoplasms 22 29 23 17
Total Animals with Metastatic Neoplasms 1 4 4 2
Total Metastatic Neoplasm 5 5 6 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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