TDMS Study 05085-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/11/94
EXP: 05085 MANGANESE SULFATE TIME: 05:12:19
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 61143B
CONT: N01-ES-45041 CAS: 7785-87-7
PATHOLOGIST: R. PERSING
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/11/94
EXP: 05085 MANGANESE SULFATE TIME: 05:12:19
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 61143B
CONT: N01-ES-45041 CAS: 7785-87-7
PATHOLOGIST: R. PERSING
MANGANESE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 4 CENSORED DEATHS 20 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 466 687 709 725 |
| CENSORED DEATHS |
| 276 276 276 276 276 276 276 277 277 277 |
| 452 452 452 452 452 452 453 453 453 453 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1500 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 6 CENSORED DEATHS 20 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 580 617 647 679 701 708 |
| CENSORED DEATHS |
| 276 276 276 276 277 277 277 277 277 277 |
| 452 452 452 452 452 453 453 453 453 453 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 5 CENSORED DEATHS 19 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 251 417 592 702 727 |
| CENSORED DEATHS |
| 276 276 276 276 276 277 277 277 277 277 |
| 452 452 452 453 453 453 453 453 453 |
| |
==================================================================================
MANGANESE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 15000 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 4 CENSORED DEATHS 20 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 140 634 645 645 |
| CENSORED DEATHS |
| 276 276 276 276 277 277 277 277 277 452 |
| 452 452 452 452 452 453 453 453 453 453 |
| |
==================================================================================
MANGANESE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0PPM | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 98.0 98.0 92.0 |
| | |
| | |
|1500 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 94.0 88.0 |
| | |
| | |
|5000 PPM | 100.0 100.0 98.6 98.6 96.9 96.9 96.9 94.9 94.9 91.0 |
| | |
| | |
|15000 PPM | 100.0 98.6 98.6 98.6 98.6 98.6 98.6 98.6 92.5 92.5 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0PPM 1500 PPM 5000 PPM 15000 PP|
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 92.0% 88.0% 91.0% 92.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.920N P=0.708 P=0.992 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 646.8 655.3 537.8 516.0 |
|NATURAL DEATHS (C) | (60.8) (20.5) (90.2) ( 125) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 620.1 618.6 615.2 615.2 |
|(STANDARD ERROR) | (20.6) (20.4) (21.2) (21.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MANGANESE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 8 CENSORED DEATHS 20 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 323 397 537 607 620 696 708 720 |
| CENSORED DEATHS |
| 276 276 276 276 276 276 276 276 277 277 |
| 277 452 452 452 453 453 453 453 453 453 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1500 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 4 CENSORED DEATHS 20 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 679 701 712 720 |
| CENSORED DEATHS |
| 276 276 276 276 276 277 277 277 277 277 |
| 452 452 452 452 453 453 453 453 453 453 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 12 CENSORED DEATHS 20 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 107 409 488 554 607 610 693 696 702 704 |
| 723 725 |
| CENSORED DEATHS |
| 19 276 276 276 277 277 277 277 277 277 |
| 277 452 452 452 452 453 453 453 453 453 |
| |
==================================================================================
MANGANESE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 15000 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 9 CENSORED DEATHS 19 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 447 473 488 631 676 689 696 709 726 |
| CENSORED DEATHS |
| 276 276 276 276 277 277 277 277 277 277 |
| 452 452 452 452 452 452 453 453 453 |
| |
==================================================================================
MANGANESE SULFATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0PPM | 100.0 100.0 100.0 98.3 96.6 96.6 94.6 94.6 90.6 84.5 |
| | |
| | |
|1500 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.0 |
| | |
| | |
|5000 PPM | 100.0 98.6 98.6 98.6 96.9 96.9 94.8 92.8 88.8 76.7 |
| | |
| | |
|15000 PPM | 100.0 100.0 100.0 100.0 100.0 96.4 94.4 94.4 92.4 82.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0PPM 1500 PPM 5000 PPM 15000 PP|
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 84.5% 92.0% 76.7% 82.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.563 P=0.318N P=0.456 P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 576.0 703.0 584.8 615.0 |
|NATURAL DEATHS (C) | (52.3) ( 8.9) (52.3) (37.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 604.8 623.4 594.0 614.1 |
|(STANDARD ERROR) | (21.4) (20.5) (23.1) (20.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
MANGANESE SULFATE
KAPLAN-MEIER SURVIVAL CURVES
0PPM = 1
1500 PPM = 2
5000 PPM = 3
15000 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
|
|
| 4 3 3 4
P 98 + 1 2 2 1
E |
R | 3 3
C | 4 4
E 96 + 2 2 1 1
N |
T | 3 3
|
S 94 + 2 2 1 1
U |
R | 3 3
V | 4 4
I 92 + 2 2 1 1
V |
A | 3 3
L |
90 + 22
|
|
|
88 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
MANGANESE SULFATE
KAPLAN-MEIER SURVIVAL CURVES
0PPM = 1
1500 PPM = 2
5000 PPM = 3
15000 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100.0 +1 3 1 4 2
|
| 3 3
| 1 1 4 4 2 2
97.5 +
| 1 3 3 1
| 4 4 22
|
95.0 + 3 3
| 4 1 1 4
| 22
| 3 3
P 92.5 + 1 1 4 4
E | 2 2
R |
C | 331 4 41
E 90.0 +
N |
T | 3 31 1
|
S 87.5 +
U | 33
R | 4 11
V |
I 85.0 + 33
V | 414 1
A |
L |
82.5 + 4 4
|
|
| 3 3
80.0 +
|
|
|
77.5 +
| 3 3
|
|
75.0 +
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 6 obs hidden.