TDMS Study 05085-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
MANGANESE SULFATE
NTP Experiment-Test: 05085-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7785-87-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 19 20
Early Deaths
Natural Death 7 2 2 1
Moribund Sacrifice 6 11 6 11
Accidently Killed 1
Survivors
Terminal Sacrifice 37 37 42 36
Wrong Sex 2
Animals Examined Microscopically 70 61 62 68
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (70) (51) (50) (68)
Parasite Metazoan 1 (1%) 2 (3%)
Intestine Large, Rectum (70) (51) (50) (68)
Inflammation, Chronic Active 1 (1%)
Parasite Metazoan 2 (3%) 2 (4%) 3 (6%) 2 (3%)
Intestine Small, Jejunum (70) (51) (51) (68)
Inflammation, Chronic Active 2 (4%)
Liver (70) (54) (52) (68)
Bacterium 1 (1%)
Basophilic Focus 45 (64%) 42 (78%) 36 (69%) 46 (68%)
Clear Cell Focus 5 (7%) 3 (6%) 4 (8%) 7 (10%)
Degeneration, Cystic 2 (4%) 3 (6%) 1 (1%)
Hematopoietic Cell Proliferation 1 (1%) 1 (2%) 4 (6%)
Hepatodiaphragmatic Nodule 7 (10%) 9 (17%) 6 (12%) 8 (12%)
Hyperplasia 1 (1%) 1 (2%) 2 (3%)
Inflammation, Chronic 34 (49%) 35 (65%) 31 (60%) 43 (63%)
Leukocytosis 1 (1%) 1 (1%)
Necrosis, Coagulative 3 (4%) 3 (6%) 3 (6%) 2 (3%)
Thrombosis 1 (1%)
Vacuolization Cytoplasmic 16 (23%) 15 (28%) 18 (35%) 17 (25%)
Bile Duct, Cyst 1 (1%) 1 (2%)
Bile Duct, Hyperplasia 36 (51%) 31 (57%) 35 (67%) 33 (49%)
Mesentery (3) (4) (5) (2)
Inflammation, Chronic Active 1 (20%)
Inflammation, Necrotizing 2 (67%) 3 (75%) 1 (20%) 1 (50%)
Necrosis 1 (25%) 1 (20%)
Pancreas (70) (50) (50) (68)
Infiltration Cellular, Lipocyte 34 (49%) 31 (62%) 36 (72%) 27 (40%)
Inflammation, Chronic Active 1 (2%)
Acinus, Amyloid Deposition 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Atrophy 10 (14%) 16 (32%) 13 (26%) 14 (21%)
Perivascular, Inflammation, Chronic Active 1 (1%) 1 (1%)
Salivary Glands (70) (51) (50) (68)
Atrophy 1 (1%)
Acinus, Hyperplasia 1 (1%)
Stomach, Forestomach (70) (51) (50) (68)
Acanthosis 4 (6%) 5 (10%) 4 (8%) 7 (10%)
Hyperkeratosis 1 (1%) 1 (2%) 2 (4%) 2 (3%)
Inflammation, Chronic Active 3 (4%) 3 (6%) 1 (2%) 3 (4%)
Perforation 1 (1%)
Stomach, Glandular (70) (51) (50) (68)
Erosion 1 (1%) 1 (2%)
Inflammation, Chronic Active 4 (6%) 4 (8%) 1 (1%)
Mineralization 1 (2%)
Tooth (60) (51) (51) (58)
Inflammation, Chronic Active 3 (6%) 2 (4%) 3 (5%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (69) (51) (51) (68)
Cardiomyopathy, Chronic 38 (55%) 32 (63%) 34 (67%) 38 (56%)
Degeneration, Chronic 2 (3%) 2 (3%)
Atrium, Thrombosis 1 (1%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (70) (51) (51) (68)
Degeneration, Fatty 27 (39%) 23 (45%) 28 (55%) 27 (40%)
Hematocyst 1 (1%)
Hematopoietic Cell Proliferation 1 (1%)
Hyperplasia 25 (36%) 23 (45%) 24 (47%) 20 (29%)
Hypertrophy 5 (7%) 2 (4%) 3 (6%) 1 (1%)
Adrenal Gland, Medulla (70) (51) (51) (68)
Hematopoietic Cell Proliferation 1 (1%)
Hyperplasia 12 (17%) 11 (22%) 6 (12%) 1 (1%)
Islets, Pancreatic (70) (50) (50) (68)
Hyperplasia 1 (2%) 1 (1%)
Vacuolization Cytoplasmic 1 (2%)
Parathyroid Gland (62) (47) (46) (65)
Hyperplasia 1 (2%)
Pituitary Gland (70) (51) (51) (67)
Craniopharyngeal Duct, Cyst 1 (1%) 2 (4%) 2 (3%)
Pars Distalis, Angiectasis 1 (1%)
Pars Distalis, Congestion 1 (1%)
Pars Distalis, Cyst 37 (53%) 29 (57%) 23 (45%) 28 (42%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia 23 (33%) 24 (47%) 24 (47%) 20 (30%)
Pars Intermedia, Cyst 1 (1%) 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (69) (51) (50) (67)
C-Cell, Hyperplasia 17 (25%) 12 (24%) 9 (18%) 19 (28%)
Follicular Cell, Cyst 1 (1%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (69) (51) (47) (63)
Hyperplasia 5 (7%) 4 (8%) 10 (21%) 6 (10%)
Inflammation, Chronic Active 21 (30%) 15 (29%) 12 (26%) 23 (37%)
Duct, Cyst 1 (2%)
Duct, Ectasia 1 (1%) 1 (2%) 1 (2%)
Ovary (70) (53) (51) (67)
Atrophy 3 (6%) 1 (2%) 1 (1%)
Cyst 6 (9%) 7 (13%) 4 (8%) 2 (3%)
Oviduct (1)
Dilatation 1 (100%)
Inflammation, Acute 1 (100%)
Uterus (70) (51) (53) (67)
Dilatation 1 (2%) 2 (4%) 1 (1%)
Hemorrhage 1 (2%)
Hyperplasia, Cystic, Glandular 3 (4%) 4 (8%) 8 (15%) 5 (7%)
Inflammation, Chronic Active 1 (1%) 1 (2%) 1 (2%)
Intussusception 1 (2%)
Endometrium, Hyperplasia 1 (1%)
Endometrium, Hyperplasia, Cystic, Glandular 1 (1%) 1 (1%)
Vagina (1) (1)
Inflammation, Suppurative 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (41) (48) (48) (48)
Polycythemia 1 (2%)
Bone Marrow (70) (51) (51) (68)
Femoral, Hyperplasia, Erythrocyte 1 (1%)
Femoral, Myelofibrosis 1 (1%) 1 (2%) 1 (2%) 1 (1%)
Lymph Node (70) (51) (51) (68)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Deep Cervical, Inflammation, Chronic Active 1 (2%)
Inguinal, Cyst 1 (2%)
Lumbar, Cyst 1 (2%)
Mediastinal, Inflammation, Chronic Active 1 (1%)
Lymph Node, Mandibular (70) (51) (50) (67)
Cyst 4 (6%) 2 (4%) 3 (4%)
Hyperplasia, Plasma Cell 1 (2%)
Spleen (70) (51) (51) (68)
Fibrosis 2 (4%)
Hematopoietic Cell Proliferation 2 (3%) 3 (6%) 1 (2%) 4 (6%)
Lymphoid Follicle, Hyperplasia 1 (1%) 1 (1%)
Thymus (64) (49) (47) (65)
Cyst 2 (3%) 2 (4%) 1 (2%)
Ectopic Parathyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (66) (50) (51) (65)
Hyperplasia, Cystic 53 (80%) 49 (98%) 49 (96%) 56 (86%)
Skin (70) (51) (51) (65)
Cyst Epithelial Inclusion 1 (1%)
Inflammation, Chronic Active 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (51) (51) (68)
Compression 4 (6%) 7 (14%) 1 (2%) 3 (4%)
Hydrocephalus 3 (4%) 6 (12%) 1 (2%) 5 (7%)
Necrosis 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (69) (51) (51) (68)
Bacterium 1 (1%)
Infiltration Cellular, Histiocyte 27 (39%) 35 (69%) 32 (63%) 29 (43%)
Inflammation, Chronic Active 8 (12%) 8 (16%) 8 (16%) 9 (13%)
Leukocytosis 1 (1%)
Metaplasia, Osseous 4 (6%)
Necrosis, Coagulative 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 1 (1%) 4 (8%) 6 (12%) 4 (6%)
Nose (70) (51) (51) (68)
Fungus 1 (1%) 1 (2%) 2 (4%) 4 (6%)
Inflammation, Chronic Active 3 (4%) 2 (4%) 6 (12%) 5 (7%)
Nasolacrimal Duct, Inflammation, Suppurative 19 (27%) 15 (29%) 16 (31%) 21 (31%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (2) (1) (4)
Cornea, Inflammation, Chronic Active 1 (50%)
Lens, Cataract 3 (75%) 2 (100%) 1 (100%) 4 (100%)
Retina, Atrophy 3 (75%) 2 (100%) 1 (100%) 3 (75%)
Harderian Gland (60) (51) (50) (58)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (59) (61) (68)
Bacterium 1 (1%)
Hydronephrosis 1 (1%)
Inflammation, Chronic Active 1 (1%)
Necrosis, Coagulative 1 (1%)
Nephropathy, Chronic 58 (83%) 59 (100%) 59 (97%) 60 (88%)
Thrombosis 1 (1%)
Renal Tubule, Hyperplasia 2 (3%)
Renal Tubule, Hyperplasia, Oncocytic 1 (1%)
Urinary Bladder (69) (51) (51) (68)
Inflammation, Hemorrhagic 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 18 19 19 18
Early Deaths
Natural Death 6 10 5 7
Moribund Sacrifice 21 24 24 38
Survivors
Natural Death 1
Terminal Sacrifice 25 17 21 7
Animals Examined Microscopically 70 70 70 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (70) (51) (50) (69)
Inflammation, Chronic Active 1 (1%) 1 (2%) 1 (1%)
Parasite Metazoan 1 (1%) 1 (1%)
Intestine Large, Colon (70) (52) (50) (70)
Inflammation, Chronic Active 1 (1%)
Mineralization 1 (2%)
Parasite Metazoan 1 (1%) 4 (8%) 4 (8%) 1 (1%)
Intestine Large, Rectum (70) (52) (51) (70)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 3 (4%) 3 (6%) 2 (4%) 2 (3%)
Thrombosis 1 (2%)
Intestine Small, Ileum (70) (51) (51) (69)
Inflammation, Chronic Active 1 (2%)
Lymphoid Tissue, Hyperplasia 1 (2%)
Liver (70) (53) (52) (70)
Basophilic Focus 12 (17%) 9 (17%) 10 (19%) 9 (13%)
Clear Cell Focus 3 (4%) 5 (9%) 3 (6%) 3 (4%)
Degeneration, Cystic 16 (23%) 19 (36%) 19 (37%) 12 (17%)
Hepatodiaphragmatic Nodule 2 (3%) 3 (6%) 1 (2%) 2 (3%)
Hyperplasia 2 (3%) 2 (4%) 2 (3%)
Inflammation, Chronic 26 (37%) 30 (57%) 25 (48%) 31 (44%)
Leukocytosis 2 (4%) 2 (4%)
Necrosis, Coagulative 4 (6%) 4 (8%) 4 (8%) 1 (1%)
Thrombosis 1 (2%) 1 (1%)
Vacuolization Cytoplasmic 23 (33%) 23 (43%) 24 (46%) 21 (30%)
Bile Duct, Hyperplasia 48 (69%) 50 (94%) 48 (92%) 47 (67%)
Hepatocyte, Atrophy 1 (2%)
Mesentery (8) (9) (5) (6)
Inflammation, Chronic Active 2 (25%)
Inflammation, Necrotizing 3 (38%) 6 (67%) 5 (100%) 5 (83%)
Pancreas (70) (51) (51) (69)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cyst 2 (3%) 1 (1%)
Ectopic Tissue 1 (2%)
Infiltration Cellular, Lipocyte 20 (29%) 13 (25%) 25 (49%) 14 (20%)
Acinus, Atrophy 26 (37%) 28 (55%) 18 (35%) 22 (32%)
Acinus, Hyperplasia 2 (3%) 1 (2%) 1 (2%)
Perivascular, Inflammation, Chronic Active 6 (9%) 2 (4%) 2 (4%) 3 (4%)
Salivary Glands (70) (48) (51) (69)
Sublingual Gland, Hyperplasia 1 (1%)
Stomach, Forestomach (70) (54) (52) (70)
Acanthosis 19 (27%) 12 (22%) 11 (21%) 11 (16%)
Diverticulum 1 (2%)
Hyperkeratosis 3 (4%) 3 (6%) 6 (12%) 2 (3%)
Inflammation, Chronic Active 11 (16%) 8 (15%) 8 (15%) 8 (11%)
Mineralization 2 (3%) 4 (7%) 3 (6%) 2 (3%)
Stomach, Glandular (70) (52) (52) (70)
Erosion 2 (4%) 1 (2%)
Inflammation, Chronic Active 4 (6%) 8 (15%) 8 (15%) 4 (6%)
Mineralization 8 (11%) 13 (25%) 9 (17%) 23 (33%)
Tooth (61) (50) (51) (59)
Caries 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (52) (51) (51) (52)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Mineralization 4 (8%) 10 (20%) 6 (12%) 17 (33%)
Thrombosis 1 (2%) 1 (2%)
Heart (70) (52) (51) (70)
Cardiomyopathy, Chronic 57 (81%) 48 (92%) 51 (100%) 52 (74%)
Degeneration, Chronic 8 (11%) 6 (9%)
Mineralization 4 (6%) 8 (15%) 5 (10%) 9 (13%)
Atrium, Thrombosis 5 (7%) 5 (10%) 5 (10%)
Valve, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (70) (52) (51) (70)
Accessory Adrenal Cortical Nodule 1 (1%) 1 (1%)
Atypia Cellular 1 (1%)
Degeneration, Fatty 33 (47%) 27 (52%) 32 (63%) 28 (40%)
Hematopoietic Cell Proliferation 1 (1%)
Hyperplasia 21 (30%) 14 (27%) 17 (33%) 18 (26%)
Hypertrophy 4 (6%) 1 (2%) 2 (4%) 2 (3%)
Necrosis, Coagulative 1 (1%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Gland, Medulla (70) (52) (51) (70)
Atrophy 1 (2%)
Hyperplasia 28 (40%) 23 (44%) 31 (61%) 27 (39%)
Islets, Pancreatic (70) (51) (51) (69)
Hyperplasia 2 (4%) 2 (4%) 3 (4%)
Parathyroid Gland (68) (47) (49) (66)
Hyperplasia 14 (21%) 14 (30%) 12 (24%) 23 (35%)
Pituitary Gland (69) (50) (51) (68)
Mineralization 1 (1%)
Craniopharyngeal Duct, Cyst 1 (2%) 1 (2%) 2 (3%)
Pars Distalis, Cyst 8 (12%) 7 (14%) 2 (4%) 8 (12%)
Pars Distalis, Hyperplasia 21 (30%) 15 (30%) 18 (35%) 13 (19%)
Pars Distalis, Hypertrophy 1 (1%)
Pars Intermedia, Cyst 2 (4%) 1 (2%) 6 (9%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (70) (49) (51) (69)
C-Cell, Hyperplasia 19 (27%) 12 (24%) 15 (29%) 6 (9%)
Follicle, Cyst Multilocular 1 (1%) 1 (2%) 1 (1%)
Follicular Cell, Mineralization 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (3) (1) (1)
Inflammation, Chronic Active 1 (100%) 2 (67%) 1 (100%) 1 (100%)
Epididymis (70) (52) (51) (70)
Inflammation, Chronic Active 1 (1%)
Mineralization 1 (2%) 1 (1%)
Preputial Gland (70) (53) (52) (70)
Hyperplasia 3 (4%) 3 (6%) 2 (3%)
Inflammation, Chronic 1 (1%)
Inflammation, Chronic Active 52 (74%) 50 (94%) 45 (87%) 53 (76%)
Duct, Ectasia 1 (1%)
Prostate (70) (52) (51) (69)
Cyst 1 (1%) 2 (4%) 1 (2%)
Inflammation, Acute 2 (3%)
Inflammation, Chronic Active 40 (57%) 38 (73%) 44 (86%) 48 (70%)
Mineralization 1 (1%) 1 (2%)
Thrombosis 1 (1%)
Epithelium, Hyperplasia 1 (1%)
Seminal Vesicle (70) (52) (51) (70)
Hyperplasia 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 1 (1%) 2 (4%)
Mineralization 2 (3%)
Testes (70) (54) (51) (70)
Mineralization 25 (36%) 31 (57%) 22 (43%) 29 (41%)
Necrosis, Coagulative 1 (1%)
Interstitial Cell, Hyperplasia 20 (29%) 15 (28%) 10 (20%) 27 (39%)
Seminiferous Tubule, Atrophy 3 (4%) 5 (9%) 3 (6%) 8 (11%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (46) (42) (44) (41)
Leukocytosis 1 (2%) 2 (5%)
Bone Marrow (70) (52) (51) (70)
Femoral, Atrophy 2 (4%)
Femoral, Myelofibrosis 2 (4%)
Lymph Node (70) (52) (51) (70)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Pancreatic, Inflammation, Chronic Active 1 (1%)
Renal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (69) (48) (51) (68)
Cyst 5 (7%) 7 (15%) 3 (6%) 2 (3%)
Hyperplasia, Plasma Cell 2 (3%) 3 (6%)
Lymph Node, Mesenteric (68) (51) (51) (69)
Cyst 1 (1%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (1%)
Spleen (70) (52) (51) (70)
Fibrosis 4 (6%) 6 (12%) 7 (14%) 3 (4%)
Hematopoietic Cell Proliferation 2 (3%) 4 (8%) 4 (8%) 1 (1%)
Infiltration Cellular, Lipocyte 1 (1%) 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Thrombosis 1 (1%)
Thymus (66) (48) (49) (62)
Cyst 1 (2%)
Ectopic Parathyroid Gland 2 (3%) 1 (2%)
Ectopic Thyroid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (39) (36) (53)
Hyperplasia, Cystic 44 (76%) 38 (97%) 36 (100%) 39 (74%)
Skin (65) (52) (50) (70)
Acanthosis 2 (3%) 1 (2%)
Alopecia 1 (2%) 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (2%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic Active 2 (3%) 4 (8%) 3 (6%) 1 (1%)
Mineralization 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (52) (51) (70)
Cranium, Fibrous Osteodystrophy 12 (17%) 13 (25%) 11 (22%) 23 (33%)
Femur, Fibrous Osteodystrophy 12 (17%) 14 (27%) 12 (24%) 24 (34%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (51) (51) (70)
Compression 4 (6%) 4 (8%) 7 (14%) 4 (6%)
Hydrocephalus 4 (6%) 5 (10%) 8 (16%) 5 (7%)
Necrosis 1 (1%) 1 (2%)
Spinal Cord (1) (2) (1)
White Matter, Degeneration 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (52) (51) (70)
Hemorrhage 1 (1%)
Infiltration Cellular, Histiocyte 12 (17%) 18 (35%) 9 (18%) 11 (16%)
Inflammation, Chronic Active 5 (7%) 9 (17%) 9 (18%) 8 (11%)
Leukocytosis 1 (2%) 2 (4%)
Metaplasia, Osseous 1 (1%) 4 (8%) 2 (4%) 3 (4%)
Mineralization 4 (6%) 6 (12%) 6 (12%) 10 (14%)
Thrombosis 1 (1%) 1 (2%) 1 (1%)
Alveolar Epithelium, Hyperplasia 2 (3%) 3 (6%) 5 (10%) 1 (1%)
Mediastinum, Inflammation, Chronic Active 1 (2%)
Nose (70) (51) (51) (70)
Fungus 2 (3%) 4 (8%) 1 (1%)
Inflammation, Chronic Active 7 (10%) 9 (18%) 7 (14%) 11 (16%)
Nasolacrimal Duct, Inflammation, Suppurative 18 (26%) 16 (31%) 18 (35%) 17 (24%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (2) (6) (10)
Anterior Chamber, Inflammation, Suppurative 1 (10%)
Cornea, Inflammation, Chronic Active 1 (33%) 1 (50%) 3 (50%) 5 (50%)
Cornea, Mineralization 1 (33%) 3 (50%) 6 (60%)
Lens, Cataract 1 (33%) 1 (50%) 2 (33%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Retina, Atrophy 1 (33%) 1 (50%) 2 (33%) 2 (20%)
Harderian Gland (62) (51) (51) (60)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (69) (70) (70)
Hydronephrosis 1 (1%)
Infarct 1 (1%)
Nephropathy, Chronic 68 (97%) 68 (99%) 70 (100%) 68 (97%)
Thrombosis 1 (1%) 1 (1%)
Glomerulus, Inflammation, Chronic Active 1 (1%)
Renal Tubule, Hyperplasia 1 (1%) 3 (4%) 2 (3%)
Renal Tubule, Hyperplasia, Oncocytic 1 (1%)
Urinary Bladder (70) (51) (51) (70)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic Active 1 (1%)
Transitional Epithelium, Hyperplasia 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
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