Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/3568

TDMS Study 05085-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         MANGANESE SULFATE


NTP Experiment-Test: 05085-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 02:14:42




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7785-87-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           19           20                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            2            2            1                                     
    Moribund Sacrifice                                 6           11            6           11                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           37           42           36                                     
  Wrong Sex                                                                                   2                                     
  Animals Examined Microscopically                    70           61           62           68                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (70)         (51)         (50)         (68)                                   
      Parasite Metazoan                                1 (1%)                                 2 (3%)                                
   Intestine Large, Rectum                            (70)         (51)         (50)         (68)                                   
      Inflammation, Chronic Active                                                            1 (1%)                                
      Parasite Metazoan                                2 (3%)       2 (4%)       3 (6%)       2 (3%)                                
   Intestine Small, Jejunum                           (70)         (51)         (51)         (68)                                   
      Inflammation, Chronic Active                                  2 (4%)                                                          
   Liver                                              (70)         (54)         (52)         (68)                                   
      Bacterium                                                                               1 (1%)                                
      Basophilic Focus                                45 (64%)     42 (78%)     36 (69%)     46 (68%)                               
      Clear Cell Focus                                 5 (7%)       3 (6%)       4 (8%)       7 (10%)                               
      Degeneration, Cystic                                          2 (4%)       3 (6%)       1 (1%)                                
      Hematopoietic Cell Proliferation                 1 (1%)                    1 (2%)       4 (6%)                                
      Hepatodiaphragmatic Nodule                       7 (10%)      9 (17%)      6 (12%)      8 (12%)                               
      Hyperplasia                                      1 (1%)                    1 (2%)       2 (3%)                                
      Inflammation, Chronic                           34 (49%)     35 (65%)     31 (60%)     43 (63%)                               
      Leukocytosis                                     1 (1%)                                 1 (1%)                                
      Necrosis, Coagulative                            3 (4%)       3 (6%)       3 (6%)       2 (3%)                                
      Thrombosis                                       1 (1%)                                                                       
      Vacuolization Cytoplasmic                       16 (23%)     15 (28%)     18 (35%)     17 (25%)                               
      Bile Duct, Cyst                                  1 (1%)       1 (2%)                                                          
      Bile Duct, Hyperplasia                          36 (51%)     31 (57%)     35 (67%)     33 (49%)                               
   Mesentery                                          (3)          (4)          (5)          (2)                                    
      Inflammation, Chronic Active                                               1 (20%)                                            
      Inflammation, Necrotizing                        2 (67%)      3 (75%)      1 (20%)      1 (50%)                               
      Necrosis                                                      1 (25%)      1 (20%)                                            
   Pancreas                                           (70)         (50)         (50)         (68)                                   
      Infiltration Cellular, Lipocyte                 34 (49%)     31 (62%)     36 (72%)     27 (40%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Acinus, Amyloid Deposition                       1 (1%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Atrophy                                 10 (14%)     16 (32%)     13 (26%)     14 (21%)                               
      Perivascular, Inflammation, Chronic Active       1 (1%)                                 1 (1%)                                
   Salivary Glands                                    (70)         (51)         (50)         (68)                                   
      Atrophy                                                                                 1 (1%)                                
      Acinus, Hyperplasia                              1 (1%)                                                                       
   Stomach, Forestomach                               (70)         (51)         (50)         (68)                                   
      Acanthosis                                       4 (6%)       5 (10%)      4 (8%)       7 (10%)                               
      Hyperkeratosis                                   1 (1%)       1 (2%)       2 (4%)       2 (3%)                                
      Inflammation, Chronic Active                     3 (4%)       3 (6%)       1 (2%)       3 (4%)                                
      Perforation                                                                             1 (1%)                                
   Stomach, Glandular                                 (70)         (51)         (50)         (68)                                   
      Erosion                                          1 (1%)       1 (2%)                                                          
      Inflammation, Chronic Active                     4 (6%)       4 (8%)                    1 (1%)                                
      Mineralization                                                1 (2%)                                                          
   Tooth                                              (60)         (51)         (51)         (58)                                   
      Inflammation, Chronic Active                                  3 (6%)       2 (4%)       3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (69)         (51)         (51)         (68)                                   
      Cardiomyopathy, Chronic                         38 (55%)     32 (63%)     34 (67%)     38 (56%)                               
      Degeneration, Chronic                            2 (3%)                                 2 (3%)                                
      Atrium, Thrombosis                               1 (1%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (51)         (51)         (68)                                   
      Degeneration, Fatty                             27 (39%)     23 (45%)     28 (55%)     27 (40%)                               
      Hematocyst                                       1 (1%)                                                                       
      Hematopoietic Cell Proliferation                                                        1 (1%)                                
      Hyperplasia                                     25 (36%)     23 (45%)     24 (47%)     20 (29%)                               
      Hypertrophy                                      5 (7%)       2 (4%)       3 (6%)       1 (1%)                                
   Adrenal Gland, Medulla                             (70)         (51)         (51)         (68)                                   
      Hematopoietic Cell Proliferation                                                        1 (1%)                                
      Hyperplasia                                     12 (17%)     11 (22%)      6 (12%)      1 (1%)                                
   Islets, Pancreatic                                 (70)         (50)         (50)         (68)                                   
      Hyperplasia                                                   1 (2%)                    1 (1%)                                
      Vacuolization Cytoplasmic                                     1 (2%)                                                          
   Parathyroid Gland                                  (62)         (47)         (46)         (65)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (70)         (51)         (51)         (67)                                   
      Craniopharyngeal Duct, Cyst                      1 (1%)                    2 (4%)       2 (3%)                                
      Pars Distalis, Angiectasis                       1 (1%)                                                                       
      Pars Distalis, Congestion                                                               1 (1%)                                
      Pars Distalis, Cyst                             37 (53%)     29 (57%)     23 (45%)     28 (42%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia                      23 (33%)     24 (47%)     24 (47%)     20 (30%)                               
      Pars Intermedia, Cyst                            1 (1%)                    1 (2%)                                             
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (69)         (51)         (50)         (67)                                   
      C-Cell, Hyperplasia                             17 (25%)     12 (24%)      9 (18%)     19 (28%)                               
      Follicular Cell, Cyst                                                                   1 (1%)                                
      Follicular Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (69)         (51)         (47)         (63)                                   
      Hyperplasia                                      5 (7%)       4 (8%)      10 (21%)      6 (10%)                               
      Inflammation, Chronic Active                    21 (30%)     15 (29%)     12 (26%)     23 (37%)                               
      Duct, Cyst                                                                              1 (2%)                                
      Duct, Ectasia                                    1 (1%)       1 (2%)                    1 (2%)                                
   Ovary                                              (70)         (53)         (51)         (67)                                   
      Atrophy                                                       3 (6%)       1 (2%)       1 (1%)                                
      Cyst                                             6 (9%)       7 (13%)      4 (8%)       2 (3%)                                
   Oviduct                                            (1)                                                                           
      Dilatation                                       1 (100%)                                                                     
      Inflammation, Acute                              1 (100%)                                                                     
   Uterus                                             (70)         (51)         (53)         (67)                                   
      Dilatation                                                    1 (2%)       2 (4%)       1 (1%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Cystic, Glandular                   3 (4%)       4 (8%)       8 (15%)      5 (7%)                                
      Inflammation, Chronic Active                     1 (1%)       1 (2%)       1 (2%)                                             
      Intussusception                                               1 (2%)                                                          
      Endometrium, Hyperplasia                         1 (1%)                                                                       
      Endometrium, Hyperplasia, Cystic, Glandular      1 (1%)                                 1 (1%)                                
   Vagina                                             (1)                       (1)                                                 
      Inflammation, Suppurative                        1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (41)         (48)         (48)         (48)                                   
      Polycythemia                                                                            1 (2%)                                
   Bone Marrow                                        (70)         (51)         (51)         (68)                                   
      Femoral, Hyperplasia, Erythrocyte                                                       1 (1%)                                
      Femoral, Myelofibrosis                           1 (1%)       1 (2%)       1 (2%)       1 (1%)                                
   Lymph Node                                         (70)         (51)         (51)         (68)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Deep Cervical, Inflammation, Chronic Active                   1 (2%)                                                          
      Inguinal, Cyst                                                1 (2%)                                                          
      Lumbar, Cyst                                                  1 (2%)                                                          
      Mediastinal, Inflammation, Chronic Active        1 (1%)                                                                       
   Lymph Node, Mandibular                             (70)         (51)         (50)         (67)                                   
      Cyst                                             4 (6%)                    2 (4%)       3 (4%)                                
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
   Spleen                                             (70)         (51)         (51)         (68)                                   
      Fibrosis                                                                   2 (4%)                                             
      Hematopoietic Cell Proliferation                 2 (3%)       3 (6%)       1 (2%)       4 (6%)                                
      Lymphoid Follicle, Hyperplasia                   1 (1%)                                 1 (1%)                                
   Thymus                                             (64)         (49)         (47)         (65)                                   
      Cyst                                             2 (3%)       2 (4%)                    1 (2%)                                
      Ectopic Parathyroid Gland                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (66)         (50)         (51)         (65)                                   
      Hyperplasia, Cystic                             53 (80%)     49 (98%)     49 (96%)     56 (86%)                               
   Skin                                               (70)         (51)         (51)         (65)                                   
      Cyst Epithelial Inclusion                        1 (1%)                                                                       
      Inflammation, Chronic Active                                  1 (2%)                    2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (51)         (51)         (68)                                   
      Compression                                      4 (6%)       7 (14%)      1 (2%)       3 (4%)                                
      Hydrocephalus                                    3 (4%)       6 (12%)      1 (2%)       5 (7%)                                
      Necrosis                                                                                1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (69)         (51)         (51)         (68)                                   
      Bacterium                                                                               1 (1%)                                
      Infiltration Cellular, Histiocyte               27 (39%)     35 (69%)     32 (63%)     29 (43%)                               
      Inflammation, Chronic Active                     8 (12%)      8 (16%)      8 (16%)      9 (13%)                               
      Leukocytosis                                                                            1 (1%)                                
      Metaplasia, Osseous                              4 (6%)                                                                       
      Necrosis, Coagulative                                                                   1 (1%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       1500 PPM     5000 PPM     15000                                     
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 1 (1%)       4 (8%)       6 (12%)      4 (6%)                                
   Nose                                               (70)         (51)         (51)         (68)                                   
      Fungus                                           1 (1%)       1 (2%)       2 (4%)       4 (6%)                                
      Inflammation, Chronic Active                     3 (4%)       2 (4%)       6 (12%)      5 (7%)                                
      Nasolacrimal Duct, Inflammation, Suppurative    19 (27%)     15 (29%)     16 (31%)     21 (31%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (2)          (1)          (4)                                    
      Cornea, Inflammation, Chronic Active                          1 (50%)                                                         
      Lens, Cataract                                   3 (75%)      2 (100%)     1 (100%)     4 (100%)                              
      Retina, Atrophy                                  3 (75%)      2 (100%)     1 (100%)     3 (75%)                               
   Harderian Gland                                    (60)         (51)         (50)         (58)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (59)         (61)         (68)                                   
      Bacterium                                                                               1 (1%)                                
      Hydronephrosis                                                                          1 (1%)                                
      Inflammation, Chronic Active                                                            1 (1%)                                
      Necrosis, Coagulative                            1 (1%)                                                                       
      Nephropathy, Chronic                            58 (83%)     59 (100%)    59 (97%)     60 (88%)                               
      Thrombosis                                       1 (1%)                                                                       
      Renal Tubule, Hyperplasia                                     2 (3%)                                                          
      Renal Tubule, Hyperplasia, Oncocytic             1 (1%)                                                                       
   Urinary Bladder                                    (69)         (51)         (51)         (68)                                   
      Inflammation, Hemorrhagic                                                               1 (1%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 18           19           19           18                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6           10            5            7                                     
    Moribund Sacrifice                                21           24           24           38                                     
  Survivors                                                                                                                         
    Natural Death                                                                1                                                  
    Terminal Sacrifice                                25           17           21            7                                     
  Animals Examined Microscopically                    70           70           70           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (70)         (51)         (50)         (69)                                   
      Inflammation, Chronic Active                     1 (1%)       1 (2%)                    1 (1%)                                
      Parasite Metazoan                                1 (1%)                                 1 (1%)                                
   Intestine Large, Colon                             (70)         (52)         (50)         (70)                                   
      Inflammation, Chronic Active                                                            1 (1%)                                
      Mineralization                                                1 (2%)                                                          
      Parasite Metazoan                                1 (1%)       4 (8%)       4 (8%)       1 (1%)                                
   Intestine Large, Rectum                            (70)         (52)         (51)         (70)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Parasite Metazoan                                3 (4%)       3 (6%)       2 (4%)       2 (3%)                                
      Thrombosis                                                    1 (2%)                                                          
   Intestine Small, Ileum                             (70)         (51)         (51)         (69)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Lymphoid Tissue, Hyperplasia                                               1 (2%)                                             
   Liver                                              (70)         (53)         (52)         (70)                                   
      Basophilic Focus                                12 (17%)      9 (17%)     10 (19%)      9 (13%)                               
      Clear Cell Focus                                 3 (4%)       5 (9%)       3 (6%)       3 (4%)                                
      Degeneration, Cystic                            16 (23%)     19 (36%)     19 (37%)     12 (17%)                               
      Hepatodiaphragmatic Nodule                       2 (3%)       3 (6%)       1 (2%)       2 (3%)                                
      Hyperplasia                                      2 (3%)       2 (4%)                    2 (3%)                                
      Inflammation, Chronic                           26 (37%)     30 (57%)     25 (48%)     31 (44%)                               
      Leukocytosis                                                  2 (4%)       2 (4%)                                             
      Necrosis, Coagulative                            4 (6%)       4 (8%)       4 (8%)       1 (1%)                                
      Thrombosis                                                                 1 (2%)       1 (1%)                                
      Vacuolization Cytoplasmic                       23 (33%)     23 (43%)     24 (46%)     21 (30%)                               
      Bile Duct, Hyperplasia                          48 (69%)     50 (94%)     48 (92%)     47 (67%)                               
      Hepatocyte, Atrophy                                                        1 (2%)                                             
   Mesentery                                          (8)          (9)          (5)          (6)                                    
      Inflammation, Chronic Active                     2 (25%)                                                                      
      Inflammation, Necrotizing                        3 (38%)      6 (67%)      5 (100%)     5 (83%)                               
   Pancreas                                           (70)         (51)         (51)         (69)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cyst                                             2 (3%)                                 1 (1%)                                
      Ectopic Tissue                                                1 (2%)                                                          
      Infiltration Cellular, Lipocyte                 20 (29%)     13 (25%)     25 (49%)     14 (20%)                               
      Acinus, Atrophy                                 26 (37%)     28 (55%)     18 (35%)     22 (32%)                               
      Acinus, Hyperplasia                              2 (3%)       1 (2%)       1 (2%)                                             
      Perivascular, Inflammation, Chronic Active       6 (9%)       2 (4%)       2 (4%)       3 (4%)                                
   Salivary Glands                                    (70)         (48)         (51)         (69)                                   
      Sublingual Gland, Hyperplasia                    1 (1%)                                                                       
   Stomach, Forestomach                               (70)         (54)         (52)         (70)                                   
      Acanthosis                                      19 (27%)     12 (22%)     11 (21%)     11 (16%)                               
      Diverticulum                                                  1 (2%)                                                          
      Hyperkeratosis                                   3 (4%)       3 (6%)       6 (12%)      2 (3%)                                
      Inflammation, Chronic Active                    11 (16%)      8 (15%)      8 (15%)      8 (11%)                               
      Mineralization                                   2 (3%)       4 (7%)       3 (6%)       2 (3%)                                
   Stomach, Glandular                                 (70)         (52)         (52)         (70)                                   
      Erosion                                                       2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                     4 (6%)       8 (15%)      8 (15%)      4 (6%)                                
      Mineralization                                   8 (11%)     13 (25%)      9 (17%)     23 (33%)                               
   Tooth                                              (61)         (50)         (51)         (59)                                   
      Caries                                                                                  1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (52)         (51)         (51)         (52)                                   
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)       1 (2%)                                
      Mineralization                                   4 (8%)      10 (20%)      6 (12%)     17 (33%)                               
      Thrombosis                                                                 1 (2%)       1 (2%)                                
   Heart                                              (70)         (52)         (51)         (70)                                   
      Cardiomyopathy, Chronic                         57 (81%)     48 (92%)     51 (100%)    52 (74%)                               
      Degeneration, Chronic                            8 (11%)                                6 (9%)                                
      Mineralization                                   4 (6%)       8 (15%)      5 (10%)      9 (13%)                               
      Atrium, Thrombosis                               5 (7%)       5 (10%)      5 (10%)                                            
      Valve, Inflammation, Chronic Active                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (52)         (51)         (70)                                   
      Accessory Adrenal Cortical Nodule                1 (1%)                                 1 (1%)                                
      Atypia Cellular                                                                         1 (1%)                                
      Degeneration, Fatty                             33 (47%)     27 (52%)     32 (63%)     28 (40%)                               
      Hematopoietic Cell Proliferation                 1 (1%)                                                                       
      Hyperplasia                                     21 (30%)     14 (27%)     17 (33%)     18 (26%)                               
      Hypertrophy                                      4 (6%)       1 (2%)       2 (4%)       2 (3%)                                
      Necrosis, Coagulative                            1 (1%)                    2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Gland, Medulla                             (70)         (52)         (51)         (70)                                   
      Atrophy                                                                    1 (2%)                                             
      Hyperplasia                                     28 (40%)     23 (44%)     31 (61%)     27 (39%)                               
   Islets, Pancreatic                                 (70)         (51)         (51)         (69)                                   
      Hyperplasia                                                   2 (4%)       2 (4%)       3 (4%)                                
   Parathyroid Gland                                  (68)         (47)         (49)         (66)                                   
      Hyperplasia                                     14 (21%)     14 (30%)     12 (24%)     23 (35%)                               
   Pituitary Gland                                    (69)         (50)         (51)         (68)                                   
      Mineralization                                                                          1 (1%)                                
      Craniopharyngeal Duct, Cyst                                   1 (2%)       1 (2%)       2 (3%)                                
      Pars Distalis, Cyst                              8 (12%)      7 (14%)      2 (4%)       8 (12%)                               
      Pars Distalis, Hyperplasia                      21 (30%)     15 (30%)     18 (35%)     13 (19%)                               
      Pars Distalis, Hypertrophy                       1 (1%)                                                                       
      Pars Intermedia, Cyst                                         2 (4%)       1 (2%)       6 (9%)                                
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (70)         (49)         (51)         (69)                                   
      C-Cell, Hyperplasia                             19 (27%)     12 (24%)     15 (29%)      6 (9%)                                
      Follicle, Cyst Multilocular                      1 (1%)                    1 (2%)       1 (1%)                                
      Follicular Cell, Mineralization                  1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)          (3)          (1)          (1)                                    
      Inflammation, Chronic Active                     1 (100%)     2 (67%)      1 (100%)     1 (100%)                              
   Epididymis                                         (70)         (52)         (51)         (70)                                   
      Inflammation, Chronic Active                                                            1 (1%)                                
      Mineralization                                                             1 (2%)       1 (1%)                                
   Preputial Gland                                    (70)         (53)         (52)         (70)                                   
      Hyperplasia                                      3 (4%)       3 (6%)                    2 (3%)                                
      Inflammation, Chronic                            1 (1%)                                                                       
      Inflammation, Chronic Active                    52 (74%)     50 (94%)     45 (87%)     53 (76%)                               
      Duct, Ectasia                                    1 (1%)                                                                       
   Prostate                                           (70)         (52)         (51)         (69)                                   
      Cyst                                             1 (1%)       2 (4%)       1 (2%)                                             
      Inflammation, Acute                                                                     2 (3%)                                
      Inflammation, Chronic Active                    40 (57%)     38 (73%)     44 (86%)     48 (70%)                               
      Mineralization                                   1 (1%)       1 (2%)                                                          
      Thrombosis                                                                              1 (1%)                                
      Epithelium, Hyperplasia                          1 (1%)                                                                       
   Seminal Vesicle                                    (70)         (52)         (51)         (70)                                   
      Hyperplasia                                                                             1 (1%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     1 (1%)                    2 (4%)                                             
      Mineralization                                                                          2 (3%)                                
   Testes                                             (70)         (54)         (51)         (70)                                   
      Mineralization                                  25 (36%)     31 (57%)     22 (43%)     29 (41%)                               
      Necrosis, Coagulative                                                                   1 (1%)                                
      Interstitial Cell, Hyperplasia                  20 (29%)     15 (28%)     10 (20%)     27 (39%)                               
      Seminiferous Tubule, Atrophy                     3 (4%)       5 (9%)       3 (6%)       8 (11%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (46)         (42)         (44)         (41)                                   
      Leukocytosis                                                  1 (2%)       2 (5%)                                             
   Bone Marrow                                        (70)         (52)         (51)         (70)                                   
      Femoral, Atrophy                                                           2 (4%)                                             
      Femoral, Myelofibrosis                                        2 (4%)                                                          
   Lymph Node                                         (70)         (52)         (51)         (70)                                   
      Mediastinal, Hyperplasia, Plasma Cell                                      1 (2%)                                             
      Pancreatic, Inflammation, Chronic Active                                                1 (1%)                                
      Renal, Hyperplasia, Plasma Cell                               1 (2%)                                                          
   Lymph Node, Mandibular                             (69)         (48)         (51)         (68)                                   
      Cyst                                             5 (7%)       7 (15%)      3 (6%)       2 (3%)                                
      Hyperplasia, Plasma Cell                         2 (3%)                    3 (6%)                                             
   Lymph Node, Mesenteric                             (68)         (51)         (51)         (69)                                   
      Cyst                                             1 (1%)                    1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                    1 (1%)                                
   Spleen                                             (70)         (52)         (51)         (70)                                   
      Fibrosis                                         4 (6%)       6 (12%)      7 (14%)      3 (4%)                                
      Hematopoietic Cell Proliferation                 2 (3%)       4 (8%)       4 (8%)       1 (1%)                                
      Infiltration Cellular, Lipocyte                  1 (1%)       1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)       1 (2%)                                             
      Thrombosis                                                                              1 (1%)                                
   Thymus                                             (66)         (48)         (49)         (62)                                   
      Cyst                                                                                    1 (2%)                                
      Ectopic Parathyroid Gland                        2 (3%)       1 (2%)                                                          
      Ectopic Thyroid                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (39)         (36)         (53)                                   
      Hyperplasia, Cystic                             44 (76%)     38 (97%)     36 (100%)    39 (74%)                               
   Skin                                               (65)         (52)         (50)         (70)                                   
      Acanthosis                                       2 (3%)       1 (2%)                                                          
      Alopecia                                                      1 (2%)       1 (2%)                                             
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Hyperkeratosis                                   1 (2%)                                 2 (3%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation, Chronic Active                     2 (3%)       4 (8%)       3 (6%)       1 (1%)                                
      Mineralization                                                             1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (52)         (51)         (70)                                   
      Cranium, Fibrous Osteodystrophy                 12 (17%)     13 (25%)     11 (22%)     23 (33%)                               
      Femur, Fibrous Osteodystrophy                   12 (17%)     14 (27%)     12 (24%)     24 (34%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (70)         (51)         (51)         (70)                                   
      Compression                                      4 (6%)       4 (8%)       7 (14%)      4 (6%)                                
      Hydrocephalus                                    4 (6%)       5 (10%)      8 (16%)      5 (7%)                                
      Necrosis                                         1 (1%)                    1 (2%)                                             
   Spinal Cord                                        (1)          (2)                       (1)                                    
      White Matter, Degeneration                                    1 (50%)                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (52)         (51)         (70)                                   
      Hemorrhage                                                                              1 (1%)                                
      Infiltration Cellular, Histiocyte               12 (17%)     18 (35%)      9 (18%)     11 (16%)                               
      Inflammation, Chronic Active                     5 (7%)       9 (17%)      9 (18%)      8 (11%)                               
      Leukocytosis                                                  1 (2%)       2 (4%)                                             
      Metaplasia, Osseous                              1 (1%)       4 (8%)       2 (4%)       3 (4%)                                
      Mineralization                                   4 (6%)       6 (12%)      6 (12%)     10 (14%)                               
      Thrombosis                                       1 (1%)       1 (2%)                    1 (1%)                                
      Alveolar Epithelium, Hyperplasia                 2 (3%)       3 (6%)       5 (10%)      1 (1%)                                
      Mediastinum, Inflammation, Chronic Active                     1 (2%)                                                          
   Nose                                               (70)         (51)         (51)         (70)                                   
      Fungus                                           2 (3%)       4 (8%)                    1 (1%)                                
      Inflammation, Chronic Active                     7 (10%)      9 (18%)      7 (14%)     11 (16%)                               
      Nasolacrimal Duct, Inflammation, Suppurative    18 (26%)     16 (31%)     18 (35%)     17 (24%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (2)          (6)          (10)                                   
      Anterior Chamber, Inflammation, Suppurative                                             1 (10%)                               
      Cornea, Inflammation, Chronic Active             1 (33%)      1 (50%)      3 (50%)      5 (50%)                               
      Cornea, Mineralization                           1 (33%)                   3 (50%)      6 (60%)                               
      Lens, Cataract                                   1 (33%)      1 (50%)      2 (33%)      2 (20%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05085-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         MANGANESE SULFATE                                     Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 02:14:42  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       1500 PPM     5000 PPM      15000                                    
                                                                                          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Retina, Atrophy                                  1 (33%)      1 (50%)      2 (33%)      2 (20%)                               
   Harderian Gland                                    (62)         (51)         (51)         (60)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (69)         (70)         (70)                                   
      Hydronephrosis                                   1 (1%)                                                                       
      Infarct                                                                    1 (1%)                                             
      Nephropathy, Chronic                            68 (97%)     68 (99%)     70 (100%)    68 (97%)                               
      Thrombosis                                                                 1 (1%)       1 (1%)                                
      Glomerulus, Inflammation, Chronic Active                      1 (1%)                                                          
      Renal Tubule, Hyperplasia                        1 (1%)       3 (4%)                    2 (3%)                                
      Renal Tubule, Hyperplasia, Oncocytic                          1 (1%)                                                          
   Urinary Bladder                                    (70)         (51)         (51)         (70)                                   
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (1%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------