TDMS Study 05085-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
MANGANESE SULFATE
NTP Experiment-Test: 05085-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7785-87-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Scheduled Sacrifice 20 20 19 20
Early Deaths
Natural Death 7 2 2 1
Moribund Sacrifice 6 11 6 11
Accidently Killed 1
Survivors
Terminal Sacrifice 37 37 42 36
Wrong Sex 2
Animals Examined Microscopically 70 61 62 68
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (70) (51) (50) (68)
Adenocarcinoma 1 (1%)
Liver (70) (54) (52) (68)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%)
Mesentery (3) (4) (5) (2)
Liposarcoma 1 (20%)
Pancreas (70) (50) (50) (68)
Salivary Glands (70) (51) (50) (68)
Stomach, Forestomach (70) (51) (50) (68)
Squamous Cell Papilloma 2 (4%)
Stomach, Glandular (70) (51) (50) (68)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (69) (51) (51) (68)
Schwannoma Malignant, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (70) (51) (51) (68)
Adenoma 1 (1%) 1 (2%)
Carcinoma 1 (1%)
Adrenal Gland, Medulla (70) (51) (51) (68)
Pheochromocytoma Complex 1 (1%)
Page 2
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign 1 (1%) 4 (8%) 1 (1%)
Islets, Pancreatic (70) (50) (50) (68)
Adenoma 1 (2%)
Parathyroid Gland (62) (47) (46) (65)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Pituitary Gland (70) (51) (51) (67)
Pars Distalis, Adenoma 22 (31%) 17 (33%) 19 (37%) 22 (33%)
Pars Distalis, Adenoma, Multiple 1 (1%)
Pars Distalis, Carcinoma 1 (2%) 2 (3%)
Thyroid Gland (69) (51) (50) (67)
Bilateral, C-Cell, Adenoma 2 (3%)
C-Cell, Adenoma 8 (12%) 6 (12%) 6 (12%) 6 (9%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (1%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (1%)
Follicular Cell, Carcinoma 1 (1%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (69) (51) (47) (63)
Adenoma 5 (7%) 1 (2%) 6 (13%) 2 (3%)
Carcinoma 1 (2%) 1 (2%)
Ovary (70) (53) (51) (67)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 1 (2%) 1 (1%)
Granulosa-Theca Tumor Benign 1 (1%)
Uterus (70) (51) (53) (67)
Hemangiosarcoma 1 (1%)
Leiomyoma 1 (1%)
Polyp Stromal 13 (19%) 7 (14%) 8 (15%) 7 (10%)
Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (41) (48) (48) (48)
Bone Marrow (70) (51) (51) (68)
Lymph Node (70) (51) (51) (68)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (2%)
Mediastinal, Rhabdomyosarcoma, Metastatic,
Page 3
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Skeletal Muscle 1 (1%)
Lymph Node, Mandibular (70) (51) (50) (67)
Lymph Node, Mesenteric (69) (51) (51) (66)
Spleen (70) (51) (51) (68)
Hemangiosarcoma 1 (2%)
Thymus (64) (49) (47) (65)
Carcinoma, Metastatic 1 (2%)
Thymoma Benign 2 (3%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (66) (50) (51) (65)
Adenocarcinoma 1 (2%)
Fibroadenoma 15 (23%) 14 (28%) 26 (51%) 11 (17%)
Fibroadenoma, Multiple 4 (6%) 2 (4%) 5 (8%)
Skin (70) (51) (51) (65)
Basal Cell Adenoma 1 (1%)
Basal Cell Carcinoma 1 (1%)
Basosquamous Tumor Benign 1 (2%)
Keratoacanthoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (50) (50) (51) (48)
Rhabdomyosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (51) (51) (68)
Carcinoma, Metastatic, Pituitary Gland 2 (3%)
Granular Cell Tumor Benign 1 (1%)
Oligodendroglioma NOS 1 (1%)
Spinal Cord (1)
Schwannoma NOS 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (69) (51) (51) (68)
Alveolar/Bronchiolar Adenoma 1 (1%) 1 (2%) 2 (3%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Mediastinum, Rhabdomyosarcoma, Metastatic,
Skeletal Muscle 1 (1%)
Mediastinum, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (59) (61) (68)
Liposarcoma, Metastatic, Mesentery 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (69) (51) (51) (68)
Transitional Epithelium, Papilloma 1 (1%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(61) *(62) *(68)
Leukemia Mononuclear 19 (27%) 21 (34%) 26 (42%) 18 (26%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 47 51 44
Total Primary Neoplasms 99 89 108 88
Total Animals with Benign Neoplasms 40 36 45 38
Total Benign Neoplasms 75 56 75 64
Total Animals with Malignant Neoplasms 24 26 30 22
Total Malignant Neoplasms 24 32 33 23
Total Animals with Metastatic Neoplasms 3 3 3
Total Metastatic Neoplasm 3 3 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Scheduled Sacrifice 18 19 19 18
Early Deaths
Natural Death 6 10 5 7
Moribund Sacrifice 21 24 24 38
Survivors
Natural Death 1
Terminal Sacrifice 25 17 21 7
Animals Examined Microscopically 70 70 70 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (70) (51) (50) (69)
Intestine Large, Colon (70) (52) (50) (70)
Intestine Large, Rectum (70) (52) (51) (70)
Histiocytic Sarcoma 1 (1%)
Polyp Adenomatous 1 (1%)
Intestine Small, Duodenum (70) (52) (51) (70)
Intestine Small, Ileum (70) (51) (51) (69)
Intestine Small, Jejunum (70) (52) (51) (69)
Polyp Adenomatous 1 (2%)
Liver (70) (53) (52) (70)
Hepatocellular Adenoma 1 (2%)
Hepatocellular Adenoma, Multiple 1 (2%)
Histiocytic Sarcoma 1 (1%)
Mesentery (8) (9) (5) (6)
Pancreas (70) (51) (51) (69)
Acinus, Adenoma 2 (4%) 1 (2%)
Pharynx (1)
Squamous Cell Papilloma 1 (100%)
Salivary Glands (70) (48) (51) (69)
Stomach, Forestomach (70) (54) (52) (70)
Squamous Cell Papilloma 1 (2%)
Squamous Cell Papilloma, Multiple 1 (1%)
Stomach, Glandular (70) (52) (52) (70)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
Tooth (61) (50) (51) (59)
Gingiva, Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (52) (51) (70)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (70) (52) (51) (70)
Adenoma 1 (1%) 1 (1%)
Adrenal Gland, Medulla (70) (52) (51) (70)
Pheochromocytoma Malignant 1 (1%) 1 (2%)
Pheochromocytoma Complex 1 (2%) 1 (2%)
Pheochromocytoma Benign 9 (13%) 12 (23%) 12 (24%) 4 (6%)
Bilateral, Pheochromocytoma Benign 5 (7%) 5 (10%) 2 (4%) 2 (3%)
Islets, Pancreatic (70) (51) (51) (69)
Adenoma 3 (6%) 4 (8%) 3 (4%)
Carcinoma 1 (1%)
Mixed Tumor Benign 1 (2%)
Parathyroid Gland (68) (47) (49) (66)
Adenoma 1 (1%)
Pituitary Gland (69) (50) (51) (68)
Ependymoma Malignant, Metastatic, Brain 1 (1%)
Pars Distalis, Adenoma 13 (19%) 12 (24%) 14 (27%) 14 (21%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (1%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (70) (49) (51) (69)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 6 (9%) 6 (12%) 7 (14%) 4 (6%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (1%)
Follicular Cell, Adenoma 1 (1%) 1 (2%) 1 (2%) 3 (4%)
Follicular Cell, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (70) (52) (51) (70)
Preputial Gland (70) (53) (52) (70)
Adenoma 3 (4%) 2 (4%) 2 (4%)
Carcinoma 2 (3%) 2 (4%) 1 (2%) 2 (3%)
Bilateral, Carcinoma 3 (6%)
Prostate (70) (52) (51) (69)
Seminal Vesicle (70) (52) (51) (70)
Testes (70) (54) (51) (70)
Bilateral, Interstitial Cell, Adenoma 36 (51%) 31 (57%) 33 (65%) 31 (44%)
Interstitial Cell, Adenoma 12 (17%) 13 (24%) 9 (18%) 12 (17%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (46) (42) (44) (41)
Bone Marrow (70) (52) (51) (70)
Femoral, Fibrosarcoma 1 (1%)
Lymph Node (70) (52) (51) (70)
Renal, Carcinoma, Metastatic, Kidney 1 (1%)
Lymph Node, Mandibular (69) (48) (51) (68)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Lymph Node, Mesenteric (68) (51) (51) (69)
Spleen (70) (52) (51) (70)
Fibrosarcoma 1 (2%)
Hemangioma 1 (1%)
Thymus (66) (48) (49) (62)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (39) (36) (53)
Fibroadenoma 1 (2%) 1 (3%) 2 (4%)
Skin (65) (52) (50) (70)
Basal Cell Adenoma 2 (4%)
Basal Cell Carcinoma 1 (2%) 1 (2%)
Basosquamous Tumor Benign 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%)
Keratoacanthoma, Multiple 1 (1%)
Squamous Cell Carcinoma 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (1%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (1%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 2 (3%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Neurofibroma 1 (2%)
Page 9
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Neurofibrosarcoma 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (52) (51) (70)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (1%)
Squamous Cell Carcinoma, Metastatic, Tooth 1 (2%)
Femur, Fibrosarcoma 1 (1%)
Skeletal Muscle (52) (51) (51) (52)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (51) (51) (70)
Astrocytoma Malignant 2 (3%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%) 1 (2%)
Ependymoma Malignant 1 (1%)
Granular Cell Tumor Benign 1 (1%)
Spinal Cord (1) (2) (1)
Glioma Benign 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (52) (51) (70)
Alveolar/Bronchiolar Adenoma 1 (1%) 3 (6%)
Alveolar/Bronchiolar Carcinoma 2 (3%) 1 (1%)
Fibrous Histiocytoma, Metastatic, Skin 1 (1%)
Histiocytic Sarcoma 1 (1%)
Neurofibrosarcoma, Metastatic, Uncertain
Primary Site 1 (1%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (1%)
Nose (70) (51) (51) (70)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Fibrosarcoma 1 (100%)
Squamous Cell Papilloma, Multiple 1 (100%)
Zymbal's Gland (2) (1) (1)
Adenoma 1 (100%)
Carcinoma 2 (100%) 1 (100%)
Page 10
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (69) (70) (70)
Lipoma 1 (1%)
Renal Tubule, Adenoma 1 (1%) 2 (3%) 1 (1%)
Renal Tubule, Oncocytoma Benign 1 (1%) 1 (1%)
Urinary Bladder (70) (51) (51) (70)
Transitional Epithelium, Papilloma 1 (1%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(70) *(70) *(70)
Histiocytic Sarcoma 1 (1%)
Leukemia Mononuclear 32 (46%) 31 (44%) 30 (43%) 25 (36%)
Mesothelioma Malignant 2 (3%) 2 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05085-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC MANGANESE SULFATE Date: 09/11/94
Route: DOSED FEED Time: 02:14:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1500 PPM 5000 PPM 15000
PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 54 50 50 54
Total Primary Neoplasms 148 143 141 118
Total Animals with Benign Neoplasms 53 48 49 49
Total Benign Neoplasms 97 100 101 83
Total Animals with Malignant Neoplasms 38 38 34 31
Total Malignant Neoplasms 51 43 40 35
Total Animals with Metastatic Neoplasms 2 2 2 4
Total Metastatic Neoplasm 2 2 2 5
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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