TDMS Study 05085-01 Pathology Tables
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7785-87-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 5| 4| 2| 7| 5| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 2| 6| 7| 6| 7| 2| 7|
DAY ON TEST | 9| 8| 3| 7| 2| 9| 3| 2| 2| 3| 2| 2| 2| 2| 2| 4| 2| 3| 7| 3| 3| 9| 3| 7| 3|
| 9| 5| 7| 6| 8| 9| 7| 9| 9| 7| 9| 9| 9| 0| 9| 7| 9| 0| 5| 8| 0| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 3 |
Inflammation, Chronic | 2 1 1 2 2 3 1 1 2 1|
Leukocytosis | X |
Necrosis, Coagulative | 1 3 |
Thrombosis | X |
Vacuolization Cytoplasmic | 1 1 3 4 1 1 4 1 |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 1 1 1 3 1 2 1 1 1 2 1 1 3 2 1|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 3 1 1 1 2 1 2 1 1 2 2 |
Acinus, Amyloid Deposition | |
Acinus, Atrophy | 2 2 1|
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic Active | 4 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 5| 4| 2| 7| 5| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 2| 6| 7| 6| 7| 2| 7|
DAY ON TEST | 9| 8| 3| 7| 2| 9| 3| 2| 2| 3| 2| 2| 2| 2| 2| 4| 2| 3| 7| 3| 3| 9| 3| 7| 3|
| 9| 5| 7| 6| 8| 9| 7| 9| 9| 7| 9| 9| 9| 0| 9| 7| 9| 0| 5| 8| 0| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 2 1 1 2 1 1 1 3 2 2 1|
Degeneration, Chronic | 1 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 1 1 1 3 1 2 1 2 1 |
Hematocyst | X |
Hyperplasia | 2 2 2 1 1 2 1 2 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 2 2 2 2 2|
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 2 3|
Inflammation, Chronic Active | 2 1 1 1 |
Duct, Ectasia | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Oviduct | + |
Dilatation | 4 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Glandular | |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 5| 4| 2| 7| 5| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 2| 6| 7| 6| 7| 2| 7|
DAY ON TEST | 9| 8| 3| 7| 2| 9| 3| 2| 2| 3| 2| 2| 2| 2| 2| 4| 2| 3| 7| 3| 3| 9| 3| 7| 3|
| 9| 5| 7| 6| 8| 9| 7| 9| 9| 7| 9| 9| 9| 0| 9| 7| 9| 0| 5| 8| 0| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Hyperplasia, Cystic, | |
Glandular | |
Endometrium, Hyperplasia | 3 |
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | M M + + + + + M + M + M + + + + M + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Lymphoid Follicle, Hyperplasia | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | X |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 4 2 3 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1|
Inflammation, Chronic Active | 3 1 4 1 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 5| 4| 2| 7| 5| 4| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 2| 6| 7| 6| 7| 2| 7|
DAY ON TEST | 9| 8| 3| 7| 2| 9| 3| 2| 2| 3| 2| 2| 2| 2| 2| 4| 2| 3| 7| 3| 3| 9| 3| 7| 3|
| 9| 5| 7| 6| 8| 9| 7| 9| 9| 7| 9| 9| 9| 0| 9| 7| 9| 0| 5| 8| 0| 0| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X |
Inflammation, Chronic Active | 2 3 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 4 1 2 3 2 1 1 1 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | 3 |
Nephropathy, Chronic | 1 2 1 1 2 1 3 1 1 3 1 1 1 2 3 1 2 1 2 3 1|
Thrombosis | |
Renal Tubule, Hyperplasia, Oncocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 9|
| 7| 0| 0| 7| 0| 0| 0| 0| 1| 7| 7| 1| 1| 1| 1| 7| 1| 1| 5| 6| 1| 7| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Inflammation, Chronic | 2 2 1 1 1 1 2 1 1 1 1 2 2 1 1|
Leukocytosis | |
Necrosis, Coagulative | 1 |
Thrombosis | |
Vacuolization Cytoplasmic | 2 1 3 1 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 2 2 1 1 |
__________________________________________________________________________|
Mesentery | + +|
Inflammation, Necrotizing | 3 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 2 1 1 1 1 2 1 1 1 3 2 2 1 |
Acinus, Amyloid Deposition | |
Acinus, Atrophy | 1 1 2 1 |
Perivascular, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Hyperkeratosis | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 9|
| 7| 0| 0| 7| 0| 0| 0| 0| 1| 7| 7| 1| 1| 1| 1| 7| 1| 1| 5| 6| 1| 7| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 2 1 2 1 1 1 1 2 1 2 1 2 2|
Degeneration, Chronic | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 1 1 1 2 2 1 |
Hematocyst | |
Hyperplasia | 2 2 2 2 2 1 1 2 2 1|
Hypertrophy | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M M M + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X X X X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 3 2 3 3 2 3 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 |
Inflammation, Chronic Active | 2 1 1 1 1 2 3 2 3 |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
__________________________________________________________________________|
Oviduct | |
Dilatation | |
Inflammation, Acute | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Glandular | 2 3 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 9|
| 7| 0| 0| 7| 0| 0| 0| 0| 1| 7| 7| 1| 1| 1| 1| 7| 1| 1| 5| 6| 1| 7| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 2 |
Endometrium, Hyperplasia | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Lymphoid Follicle, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + + I + + + + M + + + + + + + + + + + + + M + +|
Cyst | X |
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + M + + + + M + + + + + + M + + + + + + +|
Hyperplasia, Cystic | 1 2 3 1 3 4 3 1 2 4 2 2 1 1 2 3 1 2 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 |
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 4| 7| 7| 6| 2| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 3| 3| 3| 3| 9|
| 7| 0| 0| 7| 0| 0| 0| 0| 1| 7| 7| 1| 1| 1| 1| 7| 1| 1| 5| 6| 1| 7| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Lens, Cataract | 4 4 4 |
Retina, Atrophy | 4 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | |
Nephropathy, Chronic | 2 2 1 1 2 3 1 2 1 1 2 2 1 2 1 2 3 2 2 1 1 2 1|
Thrombosis | X |
Renal Tubule, Hyperplasia, Oncocytic | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 2| 7| 2| 2| 7| 7| 7| 6| 7| 6| 7| 2| 7| 7| 7| 2| 6| | |
DAY ON TEST | 3| 3| 7| 7| 3| 7| 7| 3| 3| 3| 4| 3| 2| 3| 7| 3| 3| 2| 7| 9| | |
| 7| 2| 5| 5| 2| 5| 6| 2| 2| 2| 2| 2| 4| 2| 6| 2| 2| 9| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Basophilic Focus | X X X X X X X X X X X | 45 |
Clear Cell Focus | X X | 5 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 7 |
Hyperplasia | | 1 3.0|
Inflammation, Chronic | 2 1 1 1 1 1 2 2 2 | 34 1.4|
Leukocytosis | | 1 |
Necrosis, Coagulative | | 3 1.7|
Thrombosis | | 1 |
Vacuolization Cytoplasmic | 2 2 3 3 | 16 2.1|
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 2 1 1 1 2 2 2 1 2 | 36 1.4|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Inflammation, Necrotizing | | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Infiltration Cellular, Lipocyte | 2 1 2 1 1 1 1 1 2 1 | 34 1.4|
Acinus, Amyloid Deposition | 1 | 1 1.0|
Acinus, Atrophy | 1 2 1 | 10 1.4|
Perivascular, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Acanthosis | 2 3 | 4 2.5|
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Chronic Active | 3 4 | 3 3.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 2| 7| 2| 2| 7| 7| 7| 6| 7| 6| 7| 2| 7| 7| 7| 2| 6| | |
DAY ON TEST | 3| 3| 7| 7| 3| 7| 7| 3| 3| 3| 4| 3| 2| 3| 7| 3| 3| 2| 7| 9| | |
| 7| 2| 5| 5| 2| 5| 6| 2| 2| 2| 2| 2| 4| 2| 6| 2| 2| 9| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Erosion | | 1 2.0|
Inflammation, Chronic Active | 2 | 4 2.5|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + M + + + + + + + + + + + + + + + + | 69 |
Cardiomyopathy, Chronic | 2 2 1 1 2 2 1 1 2 2 | 38 1.5|
Degeneration, Chronic | 1 | 2 1.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Degeneration, Fatty | 1 4 3 2 1 2 1 | 27 1.6|
Hematocyst | | 1 |
Hyperplasia | 2 4 1 2 2 1 | 25 1.8|
Hypertrophy | 2 3 | 5 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 1 1 1 2 | 12 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + + M + + + + + + + + M + | 62 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Craniopharyngeal Duct, Cyst | X | 1 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | X X X X X | 37 |
Pars Distalis, Hyperplasia | 2 2 2 2 3 3 2 2 | 23 2.3|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + | 69 |
C-Cell, Hyperplasia | 2 1 2 1 | 17 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia | 2 | 5 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 2| 7| 2| 2| 7| 7| 7| 6| 7| 6| 7| 2| 7| 7| 7| 2| 6| | |
DAY ON TEST | 3| 3| 7| 7| 3| 7| 7| 3| 3| 3| 4| 3| 2| 3| 7| 3| 3| 2| 7| 9| | |
| 7| 2| 5| 5| 2| 5| 6| 2| 2| 2| 2| 2| 4| 2| 6| 2| 2| 9| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 1 3 1 2 3 2 1 2 | 21 1.7|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | | 6 |
__________________________________________________________________________|____________|
Oviduct | | 1 |
Dilatation | | 1 4.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Cystic, Glandular | | 3 2.3|
Inflammation, Chronic Active | | 1 2.0|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 1 2.0|
Endometrium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + M + + + + M | 41 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Femoral, Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 70 |
Mediastinal, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Lymphoid Follicle, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + | 64 |
Cyst | | 2 |
Ectopic Parathyroid Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 66 |
Hyperplasia, Cystic | 1 3 3 2 2 2 2 2 3 2 2 2 2 4 | 53 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 4| 7| 2| 2| 7| 2| 2| 7| 7| 7| 6| 7| 6| 7| 2| 7| 7| 7| 2| 6| | |
DAY ON TEST | 3| 3| 7| 7| 3| 7| 7| 3| 3| 3| 4| 3| 2| 3| 7| 3| 3| 2| 7| 9| | |
| 7| 2| 5| 5| 2| 5| 6| 2| 2| 2| 2| 2| 4| 2| 6| 2| 2| 9| 5| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Compression | X X | 4 |
Hydrocephalus | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + M + + + + + + + + + + + + + + + + | 69 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 | 27 1.0|
Inflammation, Chronic Active | 2 | 8 1.8|
Metaplasia, Osseous | 1 1 | 4 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Fungus | | 1 |
Inflammation, Chronic Active | | 3 2.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 1 1 1 | 19 1.9|
__________________________________________________________________________|____________|
Trachea | + + + M + + + + + + + + + + + + + + + + | 69 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Lens, Cataract | | 3 4.0|
Retina, Atrophy | | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Necrosis, Coagulative | | 1 3.0|
Nephropathy, Chronic | 1 3 3 2 1 3 1 2 1 3 1 1 1 1 | 58 1.7|
Thrombosis | | 1 |
Renal Tubule, Hyperplasia, Oncocytic | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 4| 4| 2| 4| 7| 5| 4| 2| 2| 2| 7| 2| 7| 3| 7| 5| 7| 4| 7| 6| 7| 7| 2| 7|
DAY ON TEST | 1| 3| 3| 7| 5| 2| 4| 9| 7| 7| 7| 2| 7| 2| 9| 2| 4| 2| 3| 2| 0| 2| 3| 7| 3|
| 8| 7| 7| 6| 1| 9| 8| 1| 6| 6| 6| 9| 5| 9| 6| 9| 3| 9| 7| 9| 9| 9| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X X|
Degeneration, Cystic | |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic | 1 1 2 2 2 2 2 1 2 1 1 2|
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 1 1 4 1 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 2 1 2|
__________________________________________________________________________|
Mesentery | + +|
Inflammation, Necrotizing | 3 4|
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + +|
Infiltration Cellular, Lipocyte | 1 1 2 2 1 1 2 2 1 1|
Inflammation, Chronic Active | 2 |
Acinus, Atrophy | 4 3 2 1 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Acanthosis | 2 4 |
Hyperkeratosis | 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic Active | 4 |
Mineralization | 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 4| 4| 2| 4| 7| 5| 4| 2| 2| 2| 7| 2| 7| 3| 7| 5| 7| 4| 7| 6| 7| 7| 2| 7|
DAY ON TEST | 1| 3| 3| 7| 5| 2| 4| 9| 7| 7| 7| 2| 7| 2| 9| 2| 4| 2| 3| 2| 0| 2| 3| 7| 3|
| 8| 7| 7| 6| 1| 9| 8| 1| 6| 6| 6| 9| 5| 9| 6| 9| 3| 9| 7| 9| 9| 9| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 1 1 2 2 1 1 1 1 1|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 1 2 1 2 2|
Hyperplasia | 1 1 2 1 |
Hypertrophy | 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Parathyroid Gland | + + M M + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 2 3 1 3 3 2 2 1|
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 2 2|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 |
Inflammation, Chronic Active | 1 1 2 2 2 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Cystic, Glandular | 3|
Inflammation, Chronic Active | |
Intussusception | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + M + + + + + + + M + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 4| 4| 2| 4| 7| 5| 4| 2| 2| 2| 7| 2| 7| 3| 7| 5| 7| 4| 7| 6| 7| 7| 2| 7|
DAY ON TEST | 1| 3| 3| 7| 5| 2| 4| 9| 7| 7| 7| 2| 7| 2| 9| 2| 4| 2| 3| 2| 0| 2| 3| 7| 3|
| 8| 7| 7| 6| 1| 9| 8| 1| 6| 6| 6| 9| 5| 9| 6| 9| 3| 9| 7| 9| 9| 9| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Deep Cervical, Inflammation, Chronic | |
Active | |
Inguinal, Cyst | |
Lumbar, Cyst | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 2 2 2 1 3 3 4 2 2 2 2 3 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 3 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Fungus | X |
Inflammation, Chronic Active | 4 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 2 3 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + A |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 4| 4| 2| 4| 7| 5| 4| 2| 2| 2| 7| 2| 7| 3| 7| 5| 7| 4| 7| 6| 7| 7| 2| 7|
DAY ON TEST | 1| 3| 3| 7| 5| 2| 4| 9| 7| 7| 7| 2| 7| 2| 9| 2| 4| 2| 3| 2| 0| 2| 3| 7| 3|
| 8| 7| 7| 6| 1| 9| 8| 1| 6| 6| 6| 9| 5| 9| 6| 9| 3| 9| 7| 9| 9| 9| 0| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Inflammation, Chronic Active | |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 1 1 1 2 2 1 2 2 1 1 1 2 1 2 1 2 2 1|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 4| 6| 7| 2| 7| 5| 2| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 7| 2| 4| 7| 3| 6| 3| 3| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 7| 0| 5| 1| 7| 3| 1| 5| 9| 0| 5| 1| 8| 1| 7| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
1500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 1 2 1 1 2 1 1 2 1 3 1 2 2 2 2 |
Necrosis, Coagulative | 1 2 |
Vacuolization Cytoplasmic | 1 1 3 3 3 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 2 2 2 1 1|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Necrotizing | 4 |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 1 1 1 1 2 1 1 1 1 1 1|
Inflammation, Chronic Active | |
Acinus, Atrophy | 1 1 1 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 4 2 |
Hyperkeratosis | |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic Active | 2 2 3 |
Mineralization | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 4| 6| 7| 2| 7| 5| 2| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 7| 2| 4| 7| 3| 6| 3| 3| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 7| 0| 5| 1| 7| 3| 1| 5| 9| 0| 5| 1| 8| 1| 7| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
1500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 1 1 2 2 1 1 1 2 1 1 1|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 2 1 2 1 1 1 1 1 |
Hyperplasia | 2 1 2 1 2 1 2 2 2 1 1|
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X X X X X|
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2|
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 2 2|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Inflammation, Chronic Active | 1 2 3 1|
Duct, Ectasia | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Cystic, Glandular | 2 4 3 |
Inflammation, Chronic Active | 4 |
Intussusception | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 4| 6| 7| 2| 7| 5| 2| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 7| 2| 4| 7| 3| 6| 3| 3| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 7| 0| 5| 1| 7| 3| 1| 5| 9| 0| 5| 1| 8| 1| 7| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
1500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Deep Cervical, Inflammation, Chronic | |
Active | |
Inguinal, Cyst | |
Lumbar, Cyst | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 4 3 2 3 2 2 3 2 4 4 1 4 3 1 3 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hydrocephalus | 2 3 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 2 2 2 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 4| 6| 7| 2| 7| 5| 2| 7| 5| 7| 4| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 7| 3| 7| 2| 4| 7| 3| 6| 3| 3| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 7| 0| 5| 1| 7| 3| 1| 5| 9| 0| 5| 1| 8| 1| 7| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
1500 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Inflammation, Chronic Active | 2 |
Lens, Cataract | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 3 1 1 1 1 1 2 1 1 1 2 1 1 2 1 1 1 3 2 1|
Renal Tubule, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 2| 4| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 2| 3| 6| | |
| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 7| 8| 7| 2| 2| 6| 7| 9| 2| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 51 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | 4 | 2 3.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 54 |
Basophilic Focus | X X X X X X X X X X X X X | 42 |
Clear Cell Focus | X | 3 |
Degeneration, Cystic | 2 1 | 2 1.5|
Hepatodiaphragmatic Nodule | X X X X | 9 |
Inflammation, Chronic | 1 1 2 2 1 1 1 2 | 35 1.5|
Necrosis, Coagulative | 2 | 3 1.7|
Vacuolization Cytoplasmic | 2 2 3 4 1 | 15 2.1|
Bile Duct, Cyst | X | 1 |
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 2 2 3 2 | 31 1.4|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Inflammation, Necrotizing | | 3 3.7|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lipocyte | 1 1 1 1 1 1 1 1 1 1 | 31 1.2|
Inflammation, Chronic Active | | 1 2.0|
Acinus, Atrophy | 1 1 1 1 | 16 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 51 |
Acanthosis | 3 | 5 3.0|
Hyperkeratosis | | 1 3.0|
Inflammation, Chronic Active | 3 | 3 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 51 |
Erosion | | 1 2.0|
Inflammation, Chronic Active | | 4 2.8|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 2| 4| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 2| 3| 6| | |
| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 7| 8| 7| 2| 2| 6| 7| 9| 2| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | 4 | 3 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 51 |
Cardiomyopathy, Chronic | 2 1 1 1 1 2 2 2 2 | 32 1.3|
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + | 51 |
Degeneration, Fatty | 1 1 1 2 3 1 | 23 1.3|
Hyperplasia | 1 2 2 2 2 2 2 3 | 23 1.7|
Hypertrophy | 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + | 51 |
Hyperplasia | 2 2 2 2 2 | 11 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 50 |
Hyperplasia | 2 | 1 2.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 51 |
Pars Distalis, Cyst | X X X X X X X X X | 29 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 2 2 | 24 2.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 51 |
C-Cell, Hyperplasia | 2 1 2 | 12 1.8|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + M | 51 |
Hyperplasia | | 4 2.8|
Inflammation, Chronic Active | 2 2 2 2 2 | 15 1.8|
Duct, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 53 |
Atrophy | | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 2| 4| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 2| 3| 6| | |
| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 7| 8| 7| 2| 2| 6| 7| 9| 2| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | X X | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 51 |
Dilatation | 4 | 1 4.0|
Hyperplasia, Cystic, Glandular | | 4 3.0|
Inflammation, Chronic Active | | 1 4.0|
Intussusception | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 51 |
Femoral, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + | 51 |
Deep Cervical, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
Inguinal, Cyst | X | 1 |
Lumbar, Cyst | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 51 |
Hematopoietic Cell Proliferation | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 49 |
Cyst | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 50 |
Hyperplasia, Cystic | 4 3 3 4 3 2 4 4 3 4 2 2 2 3 3 | 49 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 51 |
Compression | X X | 7 |
Hydrocephalus | 3 2 | 6 2.5|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 7| 2| 4| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 7| 3| 2| 3| 6| | |
| 1| 1| 1| 2| 2| 2| 2| 2| 2| 7| 7| 8| 7| 2| 2| 6| 7| 9| 2| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1500 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 51 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 | 35 1.0|
Inflammation, Chronic Active | 1 1 | 8 1.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 51 |
Fungus | | 1 |
Inflammation, Chronic Active | 2 | 2 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 1 | 15 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic Active | | 1 2.0|
Lens, Cataract | | 2 3.5|
Retina, Atrophy | | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 59 |
Nephropathy, Chronic | 3 1 2 2 2 1 1 1 1 1 1 1 1 2 2 1 1 2 1 | 59 1.4|
Renal Tubule, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 5| 0| 7| 7| 7| 2| 4| 7| 7| 7| 5| 4| 2| 7| 2| 4| 7| 7| 7| 2| 7| 2| 2| 6|
DAY ON TEST | 2| 9| 7| 2| 2| 2| 7| 3| 2| 2| 2| 7| 3| 7| 2| 7| 3| 2| 2| 3| 7| 3| 7| 7| 8|
| 9| 9| 8| 9| 9| 9| 6| 7| 9| 9| 9| 1| 7| 5| 9| 6| 7| 9| 9| 0| 6| 0| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
5000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X|
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 4 |
Inflammation, Chronic | 1 1 2 1 3 1 1 1 2 2 1 2|
Necrosis, Coagulative | 1 |
Vacuolization Cytoplasmic | 3 4 2 1 1 |
Bile Duct, Hyperplasia | 2 3 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | |
Inflammation, Necrotizing | |
Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 2 1 1 1 1 1 1 1 1 1 |
Acinus, Atrophy | 2 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 1 2 1 1 1 3 2 2 2 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 5| 0| 7| 7| 7| 2| 4| 7| 7| 7| 5| 4| 2| 7| 2| 4| 7| 7| 7| 2| 7| 2| 2| 6|
DAY ON TEST | 2| 9| 7| 2| 2| 2| 7| 3| 2| 2| 2| 7| 3| 7| 2| 7| 3| 2| 2| 3| 7| 3| 7| 7| 8|
| 9| 9| 8| 9| 9| 9| 6| 7| 9| 9| 9| 1| 7| 5| 9| 6| 7| 9| 9| 0| 6| 0| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
5000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 2 3 2 3 2 2 1 |
Hyperplasia | 3 2 1 2 1 1 |
Hypertrophy | 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 3 2 3 2 2 2 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M M + + M + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | 4 |
Hyperplasia, Cystic, Glandular | 3 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + +|
Cyst | |
Hyperplasia, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 5| 0| 7| 7| 7| 2| 4| 7| 7| 7| 5| 4| 2| 7| 2| 4| 7| 7| 7| 2| 7| 2| 2| 6|
DAY ON TEST | 2| 9| 7| 2| 2| 2| 7| 3| 2| 2| 2| 7| 3| 7| 2| 7| 3| 2| 2| 3| 7| 3| 7| 7| 8|
| 9| 9| 8| 9| 9| 9| 6| 7| 9| 9| 9| 1| 7| 5| 9| 6| 7| 9| 9| 0| 6| 0| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
5000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 3 2 4 2 4 3 2 3 1 2 2 2 2 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Compression | |
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + +|
Fungus | X X |
Inflammation, Chronic Active | 3 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 1 3 3 1 1 1 3 3 3 2 1 2 1 2 2 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 2| 4| 7| 2| 0| 7| 6| 2| 7| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 7| 3| 3| 7| 4| 3| 6| 7| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 7| 7| 5| 7| 0| 6| 5| 0| 6| 5| 0| 0| 5| 0| 0| 7| 0| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
5000 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X |
Degeneration, Cystic | |
Hematopoietic Cell Proliferation | 2|
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia | |
Inflammation, Chronic | 1 1 1 1 1 2 1 1 2|
Necrosis, Coagulative | 2 |
Vacuolization Cytoplasmic | 1 3 1 1 1 1 1|
Bile Duct, Hyperplasia | 1 1 1 2 1 1 2 2 1 2 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic Active | 3 |
Inflammation, Necrotizing | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 1 1 2 1 1 1 1 1 1 2 1 2|
Acinus, Atrophy | 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + +|
Acanthosis | 4 |
Hyperkeratosis | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 1 1 2 1 1 1 1 1 1|
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 2| 4| 7| 2| 0| 7| 6| 2| 7| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 7| 3| 3| 7| 4| 3| 6| 7| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 7| 7| 5| 7| 0| 6| 5| 0| 6| 5| 0| 0| 5| 0| 0| 7| 0| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
5000 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 2 1 1 1 2 2 1 |
Hyperplasia | 2 2 2 2 2 2 2 1 2 2 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | X |
Pars Distalis, Cyst | X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 3 3 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + +|
Hyperplasia | 2 3 4 3 |
Inflammation, Chronic Active | 1 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
Hyperplasia, Cystic, Glandular | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Vagina | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | M + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 7| 4| 4| 2| 4| 7| 2| 0| 7| 6| 2| 7| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 7| 3| 3| 7| 4| 3| 6| 7| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 0| 7| 7| 5| 7| 0| 6| 5| 0| 6| 5| 0| 0| 5| 0| 0| 7| 0| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
5000 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 2 3 4 3 4 2 2 3 3 2 2 2 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Compression | |
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 1 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 1 1 1 1 1 1 1 3 1 2 2 1 1 2 1 2 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
5000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + | 50 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 52 |
Basophilic Focus | X X X X X X X X X X X X X X X | 36 |
Clear Cell Focus | X | 4 |
Degeneration, Cystic | 2 2 | 3 1.7|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | | 6 |
Hyperplasia | | 1 4.0|
Inflammation, Chronic | 2 1 1 2 1 1 2 2 2 1 | 31 1.4|
Necrosis, Coagulative | 1 | 3 1.3|
Vacuolization Cytoplasmic | 4 1 1 2 1 1 | 18 1.7|
Bile Duct, Hyperplasia | 2 1 1 1 1 2 1 1 1 1 1 1 1 2 | 35 1.3|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Necrotizing | 3 | 1 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + | 50 |
Infiltration Cellular, Lipocyte | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 | 36 1.2|
Acinus, Atrophy | 1 1 1 1 4 2 3 | 13 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + | 50 |
Acanthosis | 2 2 | 4 2.5|
Hyperkeratosis | 2 | 2 2.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
5000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + | 51 |
Cardiomyopathy, Chronic | 2 1 2 1 1 2 2 1 1 2 2 1 | 34 1.5|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + | 51 |
Degeneration, Fatty | 1 2 2 1 2 1 3 1 2 2 | 28 1.7|
Hyperplasia | 2 2 2 1 2 2 2 | 24 1.8|
Hypertrophy | 2 | 3 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + | 51 |
Hyperplasia | 2 1 | 6 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + M M + + + + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + | 51 |
Craniopharyngeal Duct, Cyst | X | 2 |
Pars Distalis, Cyst | X X X X X X X X X X X | 23 |
Pars Distalis, Hyperplasia | 2 2 2 3 3 2 3 2 2 2 2 | 24 2.3|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 2 1 1 | 9 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + | 47 |
Hyperplasia | 2 2 2 3 2 | 10 2.5|
Inflammation, Chronic Active | 2 1 4 1 1 4 2 2 | 12 1.9|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + | 51 |
Atrophy | | 1 4.0|
Cyst | X X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + | 53 |
Dilatation | 3 3 | 2 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Cystic, Glandular | 2 2 2 2 2 | 8 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
5000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | M + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + | 51 |
Femoral, Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + | 50 |
Cyst | X X | 2 |
Hyperplasia, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + | 51 |
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + | 51 |
Hyperplasia, Cystic | 2 1 3 3 2 2 2 3 3 4 3 2 3 3 3 3 3 2 | 49 2.6|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + | 51 |
Compression | X | 1 |
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + | 51 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0|
Inflammation, Chronic Active | | 8 1.4|
Alveolar Epithelium, Hyperplasia | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + | 51 |
Fungus | | 2 |
Inflammation, Chronic Active | 2 2 | 6 2.2|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4| 7| 7| | |
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 3| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 7| 2| 2| 2| 2| 7| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
5000 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Suppurative | 2 1 2 2 2 2 2 | 16 1.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 61 |
Nephropathy, Chronic | 1 1 1 2 1 2 2 1 2 1 2 1 1 1 3 2 2 1 2 1 | 59 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 6| 4| 4| 7| 7| 7| 2| 2| 2| 7| 4| 4| 4| 7| 4| 2| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 8| 3| 3| 2| 2| 2| 7| 7| 7| 2| 3| 3| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 2| 3|
| 6| 4| 7| 7| 9| 9| 9| 5| 6| 5| 9| 7| 7| 5| 9| 7| 6| 9| 7| 9| 9| 9| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15000 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | |
Hematopoietic Cell Proliferation | 2 2 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Inflammation, Chronic | 1 1 2 1 1 2 3 2 2 2 2 2 1|
Leukocytosis | |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic | 2 2 1 1 1 |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 2 1 1 1|
__________________________________________________________________________|
Mesentery | |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 2 1 1 1 1 1 1 1 1 |
Acinus, Atrophy | 1 1 2 1 3 |
Perivascular, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 3 |
Inflammation, Chronic Active | |
Perforation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 6| 4| 4| 7| 7| 7| 2| 2| 2| 7| 4| 4| 4| 7| 4| 2| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 8| 3| 3| 2| 2| 2| 7| 7| 7| 2| 3| 3| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 2| 3|
| 6| 4| 7| 7| 9| 9| 9| 5| 6| 5| 9| 7| 7| 5| 9| 7| 6| 9| 7| 9| 9| 9| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15000 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 2 2 1 1 1 1 2 1 2 1 2|
Degeneration, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 1 1 2 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 1 2 1|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | X |
Pars Distalis, Congestion | 3 |
Pars Distalis, Cyst | X X X X|
Pars Distalis, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + I + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 2 1|
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + M + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 2 2 3 1 1 3 4 2 2|
Duct, Cyst | X |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hyperplasia, Cystic, Glandular | 2 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 6| 4| 4| 7| 7| 7| 2| 2| 2| 7| 4| 4| 4| 7| 4| 2| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 8| 3| 3| 2| 2| 2| 7| 7| 7| 2| 3| 3| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 2| 3|
| 6| 4| 7| 7| 9| 9| 9| 5| 6| 5| 9| 7| 7| 5| 9| 7| 6| 9| 7| 9| 9| 9| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15000 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Hyperplasia, Cystic, | |
Glandular | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + +|
Polycythemia | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Erythrocyte | |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Lymphoid Follicle, Hyperplasia | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + M + + + + + +|
Hyperplasia, Cystic | 3 1 1 3 2 2 3 1 1 2 2 3 3 2 2 2 2 3 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + + M + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 3 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 2 |
Leukocytosis | |
Necrosis, Coagulative | |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 6| 4| 4| 7| 7| 7| 2| 2| 2| 7| 4| 4| 4| 7| 4| 2| 7| 5| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 7| 8| 3| 3| 2| 2| 2| 7| 7| 7| 2| 3| 3| 9| 2| 3| 7| 2| 2| 2| 2| 2| 3| 2| 3|
| 6| 4| 7| 7| 9| 9| 9| 5| 6| 5| 9| 7| 7| 5| 9| 7| 6| 9| 7| 9| 9| 9| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15000 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | X |
Inflammation, Chronic Active | 1 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 2 2 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Lacrimal Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Hydronephrosis | |
Inflammation, Chronic Active | |
Nephropathy, Chronic | 1 1 1 2 3 3 1 2 2 1 2 2 1 2 1 2 2 1 3 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Hemorrhagic | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 4| 6| 6| 2|
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 3| 0| 7| 7| 3| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 8| 9| 7|
| 0| 0| 0| 3| 3| 0| 0| 0| 1| 6| 6| 1| 1| 3| 1| 7| 1| 1| 1| 5| 1| 7| 0| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15000 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X |
Degeneration, Cystic | |
Hematopoietic Cell Proliferation | 3 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 3 |
Inflammation, Chronic | 1 2 2 2 1 1 3 1 2 1 2 1 2 1 1 1 |
Leukocytosis | X |
Necrosis, Coagulative | 3 2 |
Vacuolization Cytoplasmic | 1 1 3 1 3 1 2 |
Bile Duct, Hyperplasia | 1 1 1 2 1 2 3 1 1 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Necrotizing | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 1 1 2 1 1 2 1 1 |
Acinus, Atrophy | 3 2 2 1 1 |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 2 |
Hyperkeratosis | 3 |
Inflammation, Chronic Active | 3 |
Perforation | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 4| 6| 6| 2|
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 3| 0| 7| 7| 3| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 8| 9| 7|
| 0| 0| 0| 3| 3| 0| 0| 0| 1| 6| 6| 1| 1| 3| 1| 7| 1| 1| 1| 5| 1| 7| 0| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15000 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 1 2 2 1 2 2 2 2 1 1 |
Degeneration, Chronic | 3 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 2 1 1 1 1 2 1 2 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 1 2 2 2 2 1 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | X |
Pars Distalis, Congestion | |
Pars Distalis, Cyst | X X X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 2 2 2 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 1 1 1 2 2 |
Follicular Cell, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + M + M|
Hyperplasia | 3 2 2 |
Inflammation, Chronic Active | 1 2 2 2 3 2 1 1 2 |
Duct, Cyst | |
Duct, Ectasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + M + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Cystic, Glandular | 3 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 4| 6| 6| 2|
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 3| 0| 7| 7| 3| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 8| 9| 7|
| 0| 0| 0| 3| 3| 0| 0| 0| 1| 6| 6| 1| 1| 3| 1| 7| 1| 1| 1| 5| 1| 7| 0| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15000 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Hyperplasia, Cystic, | |
Glandular | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + + + + + |
Polycythemia | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Erythrocyte | 3 |
Femoral, Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 |
Lymphoid Follicle, Hyperplasia | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Cystic | 2 3 3 3 3 3 3 2 2 3 4 4 1 3 2 4 1 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + M + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 2 |
Leukocytosis | X |
Necrosis, Coagulative | 4 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 0| 7| 7| 7| 7| 2| 2| 7| 7| 7| 7| 4| 7| 7| 7| 2| 7| 4| 6| 6| 2|
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 3| 0| 7| 7| 3| 3| 2| 3| 3| 3| 3| 3| 7| 3| 3| 8| 9| 7|
| 0| 0| 0| 3| 3| 0| 0| 0| 1| 6| 6| 1| 1| 3| 1| 7| 1| 1| 1| 5| 1| 7| 0| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
15000 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fungus | X |
Inflammation, Chronic Active | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 2 2 3 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Hydronephrosis | 2 |
Inflammation, Chronic Active | 3 |
Nephropathy, Chronic | 1 2 3 2 1 2 2 1 1 1 2 1 2 1 1 3 1 1 1 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Hemorrhagic | 3 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 7| 7| 2| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 0| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 7| 3| 4| 3| 3| 3| 0| 3| | |
| 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 2| 2| 6| 7| 2| 2| 2| 2| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
15000 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | 68 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | 68 |
Inflammation, Chronic Active | | 1 2.0|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + | 68 |
Bacterium | | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X | 46 |
Clear Cell Focus | X X | 7 |
Degeneration, Cystic | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 4 2.5|
Hepatodiaphragmatic Nodule | X X X X | 8 |
Hyperplasia | 3 | 2 3.0|
Inflammation, Chronic | 2 1 2 2 1 1 2 2 1 1 2 2 1 2 | 43 1.6|
Leukocytosis | | 1 |
Necrosis, Coagulative | | 2 2.5|
Vacuolization Cytoplasmic | 1 1 2 3 2 | 17 1.6|
Bile Duct, Hyperplasia | 1 3 2 2 1 1 1 3 1 | 33 1.4|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Inflammation, Necrotizing | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + | 68 |
Infiltration Cellular, Lipocyte | 1 1 2 1 1 1 1 1 1 1 | 27 1.1|
Acinus, Atrophy | 2 2 2 1 | 14 1.7|
Perivascular, Inflammation, Chronic | | |
Active | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + | 68 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | 68 |
Acanthosis | 2 2 | 7 2.0|
Hyperkeratosis | | 2 3.0|
Inflammation, Chronic Active | 2 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 7| 7| 2| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 0| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 7| 3| 4| 3| 3| 3| 0| 3| | |
| 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 2| 2| 6| 7| 2| 2| 2| 2| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
15000 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Perforation | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | 68 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + | 58 |
Inflammation, Chronic Active | | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 68 |
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 1 1 2 1 | 38 1.6|
Degeneration, Chronic | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + | 68 |
Degeneration, Fatty | 1 2 1 1 1 1 1 1 1 1 | 27 1.3|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 3 2 2 1 2 2 1 1 | 20 1.7|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + | 68 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | 68 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M M + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + | 67 |
Craniopharyngeal Duct, Cyst | | 2 |
Pars Distalis, Congestion | | 1 3.0|
Pars Distalis, Cyst | X X X X X X X X X X X X | 28 |
Pars Distalis, Hyperplasia | 2 3 2 2 2 2 3 2 | 20 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + | 67 |
C-Cell, Hyperplasia | 1 1 2 1 1 2 | 19 1.5|
Follicular Cell, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + | 63 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 7| 7| 2| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 0| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 7| 3| 4| 3| 3| 3| 0| 3| | |
| 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 2| 2| 6| 7| 2| 2| 2| 2| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
15000 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 2 3 | 6 2.3|
Inflammation, Chronic Active | 2 1 1 1 2 | 23 1.9|
Duct, Cyst | | 1 |
Duct, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + | 67 |
Atrophy | 3 | 1 3.0|
Cyst | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + | 67 |
Dilatation | | 1 2.0|
Hyperplasia, Cystic, Glandular | 1 3 | 5 2.2|
Endometrium, Hyperplasia, Cystic, | | |
Glandular | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + | 48 |
Polycythemia | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + | 68 |
Femoral, Hyperplasia, Erythrocyte | | 1 3.0|
Femoral, Myelofibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + | 67 |
Cyst | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + | 66 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + | 68 |
Hematopoietic Cell Proliferation | | 4 2.5|
Lymphoid Follicle, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + M + + + + + + + + + + + | 65 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + | 65 |
Hyperplasia, Cystic | 2 2 2 2 3 2 1 3 3 2 3 1 4 2 4 3 2 2 | 56 2.4|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + | 65 |
Inflammation, Chronic Active | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 0| 4| 7| 4| 7| 7| 7| 7| 2| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 0| 3| 3| 3| 1| 3| 3| 3| 1| 3| 3| 3| 7| 3| 4| 3| 3| 3| 0| 3| | |
| 1| 1| 1| 2| 6| 7| 2| 7| 5| 2| 2| 2| 6| 7| 2| 2| 2| 2| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
15000 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + | 68 |
Compression | X | 3 |
Hydrocephalus | 2 3 | 5 2.4|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + | 68 |
Bacterium | | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 2 1 1 1 | 29 1.0|
Inflammation, Chronic Active | 1 1 1 2 1 | 9 1.3|
Leukocytosis | | 1 |
Necrosis, Coagulative | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 2 | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + | 68 |
Fungus | X X | 4 |
Inflammation, Chronic Active | 4 3 | 5 2.8|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 2 3 2 2 2 | 21 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Lens, Cataract | 4 4 | 4 4.0|
Retina, Atrophy | 4 | 3 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + | 58 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + | 68 |
Bacterium | | 1 |
Hydronephrosis | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Nephropathy, Chronic | 1 2 3 3 1 3 1 1 1 2 2 1 3 2 2 2 1 1 | 60 1.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + | 68 |
Inflammation, Hemorrhagic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 5| 4| 7| 6| 7| 7| 2| 7| 2| 7| 6| 6| 7| 4| 7| 7| 6| 6| 6| 2| 4|
DAY ON TEST | 3| 2| 3| 3| 7| 3| 3| 7| 3| 2| 7| 3| 7| 3| 9| 5| 2| 3| 2| 0| 0| 2| 9| 7| 3|
| 7| 6| 0| 0| 1| 7| 0| 0| 0| 6| 5| 0| 5| 0| 1| 5| 9| 7| 9| 1| 3| 7| 0| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | |
Degeneration, Cystic | 2 2 1 2 1 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Inflammation, Chronic | 1 1 2 1 1 2 1 2 1 2 1 |
Necrosis, Coagulative | 2 |
Vacuolization Cytoplasmic | 1 1 1 2 1 1 |
Bile Duct, Hyperplasia | 2 2 3 1 2 1 3 2 1 2 3 3 3 3 3 3 2 2 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic Active | 3 |
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Infiltration Cellular, Lipocyte | 1 1 |
Acinus, Atrophy | 1 1 1 2 3 2 2 1 1 1 2 2 1|
Acinus, Hyperplasia | 2 |
Perivascular, Inflammation, Chronic | |
Active | 3 3 2 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Hyperplasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 2 2 2 3 3 2 |
Hyperkeratosis | 2 2 |
Inflammation, Chronic Active | 3 4 4 3 |
Mineralization | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 5| 4| 7| 6| 7| 7| 2| 7| 2| 7| 6| 6| 7| 4| 7| 7| 6| 6| 6| 2| 4|
DAY ON TEST | 3| 2| 3| 3| 7| 3| 3| 7| 3| 2| 7| 3| 7| 3| 9| 5| 2| 3| 2| 0| 0| 2| 9| 7| 3|
| 7| 6| 0| 0| 1| 7| 0| 0| 0| 6| 5| 0| 5| 0| 1| 5| 9| 7| 9| 1| 3| 7| 0| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 4 2 2 3 4 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + |
Mineralization | 3 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 3 2 2 3 2 3 2 3 1 2 2 2 2 4 2|
Degeneration, Chronic | 2 2 3 |
Mineralization | 2 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Degeneration, Fatty | 1 1 2 4 1 2 1 1 2 3 1 1 1 2 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 2 1 1 2 |
Hypertrophy | 2 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 2 2 2 2 2 3 1 1 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X X X|
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 2 2 |
Pars Distalis, Hypertrophy | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 3 1 1 2 |
Follicle, Cyst Multilocular | |
Follicular Cell, Mineralization | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 5| 4| 7| 6| 7| 7| 2| 7| 2| 7| 6| 6| 7| 4| 7| 7| 6| 6| 6| 2| 4|
DAY ON TEST | 3| 2| 3| 3| 7| 3| 3| 7| 3| 2| 7| 3| 7| 3| 9| 5| 2| 3| 2| 0| 0| 2| 9| 7| 3|
| 7| 6| 0| 0| 1| 7| 0| 0| 0| 6| 5| 0| 5| 0| 1| 5| 9| 7| 9| 1| 3| 7| 0| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 1 2 3 2 1 2 2 2 2 2 2 2 2 4 3 2 2|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 1 2 1 2 2 2 4 1 3 2 3 |
Mineralization | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 1 2 2 1 1 |
Interstitial Cell, Hyperplasia | 1 1 1 2 1 2 2 1 1|
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + M + M + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lipocyte | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + M + + M + + + + +|
Ectopic Parathyroid Gland | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 1 1 1 2 2 3 1 1 4 2 1 2 2 3 2 2 1|
__________________________________________________________________________|
Skin | M + + + + + + + + M + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | |
Inflammation, Chronic Active | 4 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 5| 7| 7| 5| 4| 7| 6| 7| 7| 2| 7| 2| 7| 6| 6| 7| 4| 7| 7| 6| 6| 6| 2| 4|
DAY ON TEST | 3| 2| 3| 3| 7| 3| 3| 7| 3| 2| 7| 3| 7| 3| 9| 5| 2| 3| 2| 0| 0| 2| 9| 7| 3|
| 7| 6| 0| 0| 1| 7| 0| 0| 0| 6| 5| 0| 5| 0| 1| 5| 9| 7| 9| 1| 3| 7| 0| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Cranium, Fibrous Osteodystrophy | X X X X X |
Femur, Fibrous Osteodystrophy | X X X X X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 3 |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 2 |
Metaplasia, Osseous | |
Mineralization | 1 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 1 2 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | |
Cornea, Mineralization | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 2 1 3 3 2 2 3 4 3 4 2 3 1 4 2 4 2 1 4 4 2 2 4 1 1|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 2| 7| 7| 7| 7| 2| 2| 6| 4| 7| 4| 6| 2| 5| 6| 5| 5| 0| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 3| 7| 3| 2| 2| 3| 7| 7| 1| 3| 3| 3| 7| 6| 4| 2| 6| 9| 9| 3|
| 1| 1| 9| 1| 5| 7| 6| 1| 9| 9| 1| 5| 6| 2| 7| 1| 7| 3| 9| 7| 1| 2| 0| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X|
Degeneration, Cystic | 1 1 1 2|
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 3 |
Inflammation, Chronic | 2 1 1 3 2 2 1 1 1 2 |
Necrosis, Coagulative | 1 2 2 |
Vacuolization Cytoplasmic | 1 1 2 1 1 3 2 1|
Bile Duct, Hyperplasia | 2 2 3 2 2 3 2 2 3 3 3 1 3 3 2 3|
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic Active | 3 |
Inflammation, Necrotizing | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Lipocyte | 1 2 1 1 1 1 1 1 |
Acinus, Atrophy | 1 2 1 3 1 1 2 4|
Acinus, Hyperplasia | |
Perivascular, Inflammation, Chronic | |
Active | 2 4 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sublingual Gland, Hyperplasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 2 4 2 2|
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 3 4 2 2|
Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 2| 7| 7| 7| 7| 2| 2| 6| 4| 7| 4| 6| 2| 5| 6| 5| 5| 0| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 3| 7| 3| 2| 2| 3| 7| 7| 1| 3| 3| 3| 7| 6| 4| 2| 6| 9| 9| 3|
| 1| 1| 9| 1| 5| 7| 6| 1| 9| 9| 1| 5| 6| 2| 7| 1| 7| 3| 9| 7| 1| 2| 0| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mineralization | 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3 3|
Degeneration, Chronic | 2 2 1 2 |
Mineralization | |
Atrium, Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Fatty | 2 1 2 2 2 2 2 1 1 1|
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 2 2 2 2 2 2 2 |
Hypertrophy | 2 2 |
Necrosis, Coagulative | 2|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 3 2 1 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X|
Pars Distalis, Hyperplasia | 2 3 2 2 1 3 2 |
Pars Distalis, Hypertrophy | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 2 2 2 2 1 1 |
Follicle, Cyst Multilocular | X |
Follicular Cell, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 2| 7| 7| 7| 7| 2| 2| 6| 4| 7| 4| 6| 2| 5| 6| 5| 5| 0| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 3| 7| 3| 2| 2| 3| 7| 7| 1| 3| 3| 3| 7| 6| 4| 2| 6| 9| 9| 3|
| 1| 1| 9| 1| 5| 7| 6| 1| 9| 9| 1| 5| 6| 2| 7| 1| 7| 3| 9| 7| 1| 2| 0| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 2 2 2 1 2 3 2 2 1 2 2 2 2 1 1 3 2 2|
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | 2 1 1 2 3 1 1 3 2 2 3 2 1 2 |
Mineralization | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 2 2 1 1 2|
Interstitial Cell, Hyperplasia | 1 2 1 1 1 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | |
Hyperplasia, Plasma Cell | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lipocyte | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Parathyroid Gland | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + + + + + + + M M M + M + + + M M + M +|
Hyperplasia, Cystic | 1 2 1 1 1 3 3 1 3 2 3 1|
__________________________________________________________________________|
Skin | + + M + M + + M + + + + + + + + + + + + + + + + +|
Acanthosis | 4 |
Hyperkeratosis | 4 |
Inflammation, Chronic Active | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 2| 4| 2| 7| 7| 7| 7| 2| 2| 6| 4| 7| 4| 6| 2| 5| 6| 5| 5| 0| 7|
DAY ON TEST | 3| 3| 2| 3| 7| 3| 7| 3| 2| 2| 3| 7| 7| 1| 3| 3| 3| 7| 6| 4| 2| 6| 9| 9| 3|
| 1| 1| 9| 1| 5| 7| 6| 1| 9| 9| 1| 5| 6| 2| 7| 1| 7| 3| 9| 7| 1| 2| 0| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Cranium, Fibrous Osteodystrophy | X X |
Femur, Fibrous Osteodystrophy | X X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 3 |
Necrosis | 4 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Inflammation, Chronic Active | 1 |
Metaplasia, Osseous | 1 |
Mineralization | |
Thrombosis | X|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X X |
Inflammation, Chronic Active | 2 3 3 3 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 2 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | |
Cornea, Mineralization | |
Lens, Cataract | 2 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy, Chronic | 3 3 3 4 1 2 1 3 3 3 3 1 1 3 2 3 2 3 3 2 2 4 4|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 6| 6| 4| 4| 6| 6| 6| 7| 7| 5| 4| 7| 7| 2| 4| 7| 7| | |
DAY ON TEST | 3| 2| 0| 4| 7| 3| 5| 1| 7| 9| 3| 3| 7| 3| 3| 3| 7| 9| 2| 3| | |
| 7| 9| 3| 2| 3| 7| 6| 0| 7| 5| 2| 2| 8| 7| 2| 2| 6| 5| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic Active | | 1 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Basophilic Focus | X X X X X | 12 |
Clear Cell Focus | X | 3 |
Degeneration, Cystic | 2 2 2 2 | 16 1.5|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia | 4 | 2 3.5|
Inflammation, Chronic | 2 1 1 1 1 | 26 1.4|
Necrosis, Coagulative | | 4 1.8|
Vacuolization Cytoplasmic | 3 2 1 1 1 1 1 2 1 | 23 1.4|
Bile Duct, Hyperplasia | 2 3 3 3 2 2 1 2 3 2 2 2 2 2 | 48 2.3|
__________________________________________________________________________|____________|
Mesentery | + + + | 8 |
Inflammation, Chronic Active | | 2 3.0|
Inflammation, Necrotizing | 4 3 | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | | 2 |
Infiltration Cellular, Lipocyte | 1 1 1 1 1 1 1 2 1 1 | 20 1.1|
Acinus, Atrophy | 1 1 1 1 2 | 26 1.6|
Acinus, Hyperplasia | 3 | 2 2.5|
Perivascular, Inflammation, Chronic | | |
Active | | 6 2.7|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Sublingual Gland, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Acanthosis | 2 3 3 3 | 19 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 6| 6| 4| 4| 6| 6| 6| 7| 7| 5| 4| 7| 7| 2| 4| 7| 7| | |
DAY ON TEST | 3| 2| 0| 4| 7| 3| 5| 1| 7| 9| 3| 3| 7| 3| 3| 3| 7| 9| 2| 3| | |
| 7| 9| 3| 2| 3| 7| 6| 0| 7| 5| 2| 2| 8| 7| 2| 2| 6| 5| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | | 3 2.0|
Inflammation, Chronic Active | 3 2 2 | 11 2.9|
Mineralization | 3 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic Active | 2 3 | 4 2.0|
Mineralization | 3 3 | 8 2.9|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + | 61 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + | 52 |
Mineralization | 3 4 | 4 3.5|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy, Chronic | 2 1 3 2 2 2 3 2 3 3 2 2 2 3 2 2 2 3 | 57 2.2|
Degeneration, Chronic | 2 | 8 2.0|
Mineralization | 2 3 | 4 2.5|
Atrium, Thrombosis | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Accessory Adrenal Cortical Nodule | | 1 |
Degeneration, Fatty | 1 1 2 2 1 2 2 2 | 33 1.6|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | 2 1 1 2 2 2 | 21 1.8|
Hypertrophy | 2 | 4 2.0|
Necrosis, Coagulative | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 1 2 2 2 2 1 | 28 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + | 68 |
Hyperplasia | 2 2 3 2 3 | 14 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Pars Distalis, Cyst | X X | 8 |
Pars Distalis, Hyperplasia | 2 1 1 2 1 3 | 21 2.0|
Pars Distalis, Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
C-Cell, Hyperplasia | 3 1 1 | 19 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 6| 6| 4| 4| 6| 6| 6| 7| 7| 5| 4| 7| 7| 2| 4| 7| 7| | |
DAY ON TEST | 3| 2| 0| 4| 7| 3| 5| 1| 7| 9| 3| 3| 7| 3| 3| 3| 7| 9| 2| 3| | |
| 7| 9| 3| 2| 3| 7| 6| 0| 7| 5| 2| 2| 8| 7| 2| 2| 6| 5| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst Multilocular | | 1 |
Follicular Cell, Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 2 | 3 2.3|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 1 2 2 1 2 1 2 2 2 2 2 1 2 2 2 2 | 52 1.9|
Duct, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | | 1 |
Inflammation, Chronic Active | 3 2 3 2 1 2 2 3 1 2 2 2 1 1 2 | 40 2.0|
Mineralization | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Mineralization | 2 1 2 1 1 2 1 | 25 1.5|
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 | 20 1.3|
Seminiferous Tubule, Atrophy | 4 | 3 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + M + + M + M + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 69 |
Cyst | X X | 5 |
Hyperplasia, Plasma Cell | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 68 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Fibrosis | 3 3 | 4 2.5|
Hematopoietic Cell Proliferation | 3 2 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 6| 6| 4| 4| 6| 6| 6| 7| 7| 5| 4| 7| 7| 2| 4| 7| 7| | |
DAY ON TEST | 3| 2| 0| 4| 7| 3| 5| 1| 7| 9| 3| 3| 7| 3| 3| 3| 7| 9| 2| 3| | |
| 7| 9| 3| 2| 3| 7| 6| 0| 7| 5| 2| 2| 8| 7| 2| 2| 6| 5| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infiltration Cellular, Lipocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + + + + + | 66 |
Ectopic Parathyroid Gland | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + | 58 |
Hyperplasia, Cystic | 1 2 3 1 2 2 1 1 2 1 2 4 3 | 44 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 65 |
Acanthosis | | 2 3.0|
Hyperkeratosis | | 1 4.0|
Inflammation, Chronic Active | | 2 3.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Cranium, Fibrous Osteodystrophy | X X X X X | 12 |
Femur, Fibrous Osteodystrophy | X X X X X | 12 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + | 52 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Compression | X X | 4 |
Hydrocephalus | 2 4 | 4 3.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Infiltration Cellular, Histiocyte | 1 1 | 12 1.0|
Inflammation, Chronic Active | 4 | 5 1.8|
Metaplasia, Osseous | | 1 1.0|
Mineralization | 2 1 | 4 1.5|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Fungus | | 2 |
Inflammation, Chronic Active | 2 | 7 2.6|
Nasolacrimal Duct, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 6| 6| 4| 4| 6| 6| 6| 7| 7| 5| 4| 7| 7| 2| 4| 7| 7| | |
DAY ON TEST | 3| 2| 0| 4| 7| 3| 5| 1| 7| 9| 3| 3| 7| 3| 3| 3| 7| 9| 2| 3| | |
| 7| 9| 3| 2| 3| 7| 6| 0| 7| 5| 2| 2| 8| 7| 2| 2| 6| 5| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Suppurative | 2 1 4 2 1 1 | 18 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cornea, Inflammation, Chronic Active | 2 | 1 2.0|
Cornea, Mineralization | 1 | 1 1.0|
Lens, Cataract | | 1 2.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + | 62 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Hydronephrosis | 3 | 1 3.0|
Nephropathy, Chronic | 1 4 3 2 3 2 1 4 4 4 2 3 2 1 4 4 2 2 4 3 | 68 2.6|
Renal Tubule, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic Active | | 1 2.0|
Transitional Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 6| 4| 6| 2| 4| 4| 6| 6| 7| 5| 6| 6| 6| 4| 4| 7| 2| 6| 4| 6|
DAY ON TEST | 7| 2| 1| 2| 3| 1| 3| 7| 7| 3| 6| 9| 5| 2| 7| 3| 7| 9| 5| 3| 2| 7| 4| 3| 1|
| 5| 9| 1| 9| 0| 3| 7| 4| 5| 7| 6| 8| 2| 9| 8| 5| 0| 4| 1| 7| 9| 6| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | X |
Thrombosis | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X |
Degeneration, Cystic | 1 3 2 1 1 2 1|
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | |
Inflammation, Chronic | 1 1 2 1 1 2 1 1 1 2 2|
Leukocytosis | |
Necrosis, Coagulative | 3 2 3 |
Vacuolization Cytoplasmic | 2 2 3 2 1 3 |
Bile Duct, Hyperplasia | 3 2 3 2 2 4 2 2 1 2 1 3 2 2 2 2 3 2|
__________________________________________________________________________|
Mesentery | + |
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + +|
Ectopic Tissue | |
Infiltration Cellular, Lipocyte | 1 1 3 |
Acinus, Atrophy | 2 1 1 2 2 1 2|
Acinus, Hyperplasia | |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + M + + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 2 3 2 3 2|
Diverticulum | 2 |
Hyperkeratosis | 3 2 |
Inflammation, Chronic Active | 3 4 4 4 |
Mineralization | 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 6| 4| 6| 2| 4| 4| 6| 6| 7| 5| 6| 6| 6| 4| 4| 7| 2| 6| 4| 6|
DAY ON TEST | 7| 2| 1| 2| 3| 1| 3| 7| 7| 3| 6| 9| 5| 2| 7| 3| 7| 9| 5| 3| 2| 7| 4| 3| 1|
| 5| 9| 1| 9| 0| 3| 7| 4| 5| 7| 6| 8| 2| 9| 8| 5| 0| 4| 1| 7| 9| 6| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 |
Inflammation, Chronic Active | 2 3 3 3 |
Mineralization | 1 3 1 2 3 4|
__________________________________________________________________________|
Tooth | + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 4 3 4|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 2 2 2 2 2 3 3 2 2 2 2 3 2 2 2 4|
Mineralization | 3 3|
Atrium, Thrombosis | X X |
Valve, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 2 2 3 3 2 2 3 1 |
Hyperplasia | 2 2 2 1 1|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1 2 3 3 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + + + M + + + + + +|
Hyperplasia | 3 3 2 3 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Cyst | X X X|
Pars Distalis, Hyperplasia | 2 2 1 |
Pars Intermedia, Cyst | X |
Pars Nervosa, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + M + + + + + +|
C-Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + + |
Inflammation, Chronic Active | 3 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 6| 4| 6| 2| 4| 4| 6| 6| 7| 5| 6| 6| 6| 4| 4| 7| 2| 6| 4| 6|
DAY ON TEST | 7| 2| 1| 2| 3| 1| 3| 7| 7| 3| 6| 9| 5| 2| 7| 3| 7| 9| 5| 3| 2| 7| 4| 3| 1|
| 5| 9| 1| 9| 0| 3| 7| 4| 5| 7| 6| 8| 2| 9| 8| 5| 0| 4| 1| 7| 9| 6| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 2 2 4 2 1 2 1 2 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 2 2 2 2 2 2 3 2 3 3 1 4 1 1|
Mineralization | 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 1 2 1 1 2 1 2|
Interstitial Cell, Hyperplasia | 1 1 2 2 1 1|
Seminiferous Tubule, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + M M + + + M + M + + + +|
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + M + + + M + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 2 |
Hematopoietic Cell Proliferation | 3 |
Infiltration Cellular, Lipocyte | 2 |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + +|
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + M + + M + M M + M +|
Hyperplasia, Cystic | 2 1 1 2 2 2 1 3 2 4 4 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 |
Alopecia | X |
Cyst Epithelial Inclusion | X |
Inflammation, Chronic Active | 4 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X X X|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 6| 4| 6| 2| 4| 4| 6| 6| 7| 5| 6| 6| 6| 4| 4| 7| 2| 6| 4| 6|
DAY ON TEST | 7| 2| 1| 2| 3| 1| 3| 7| 7| 3| 6| 9| 5| 2| 7| 3| 7| 9| 5| 3| 2| 7| 4| 3| 1|
| 5| 9| 1| 9| 0| 3| 7| 4| 5| 7| 6| 8| 2| 9| 8| 5| 0| 4| 1| 7| 9| 6| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Femur, Fibrous Osteodystrophy | X X X X X X|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + M + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 3 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
White Matter, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 |
Inflammation, Chronic Active | 2 3 3 3|
Leukocytosis | |
Metaplasia, Osseous | 1 |
Mineralization | 3 3|
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 |
Mediastinum, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + M + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | 4 |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + A + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 3 2 2 3 2 1 2 1 3 4 4 4 3 2 4 4 2 2 4 1 3 2 4|
Glomerulus, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 6| 4| 6| 2| 4| 4| 6| 6| 7| 5| 6| 6| 6| 4| 4| 7| 2| 6| 4| 6|
DAY ON TEST | 7| 2| 1| 2| 3| 1| 3| 7| 7| 3| 6| 9| 5| 2| 7| 3| 7| 9| 5| 3| 2| 7| 4| 3| 1|
| 5| 9| 1| 9| 0| 3| 7| 4| 5| 7| 6| 8| 2| 9| 8| 5| 0| 4| 1| 7| 9| 6| 2| 7| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Hyperplasia, Oncocytic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 7| 2| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 7| 2| 4| 4| 6| 3| 2| 6| 6|
DAY ON TEST | 2| 6| 3| 7| 3| 7| 3| 7| 3| 3| 9| 9| 3| 6| 5| 3| 2| 7| 3| 3| 5| 3| 7| 8| 8|
| 9| 6| 0| 5| 0| 6| 0| 7| 1| 7| 4| 0| 1| 6| 9| 1| 3| 6| 7| 7| 8| 3| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
Mineralization | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Parasite Metazoan | X |
Thrombosis | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 2 1 1 1 2 2 1|
Hepatodiaphragmatic Nodule | |
Hyperplasia | 4|
Inflammation, Chronic | 1 2 1 1 1 1 1 1 1 2 2 |
Leukocytosis | X X |
Necrosis, Coagulative | 3 |
Vacuolization Cytoplasmic | 2 3 2 2 1 2 3 2 3 3 2|
Bile Duct, Hyperplasia | 3 1 2 2 2 2 2 2 3 2 2 3 2 2 2 1 4 4|
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Necrotizing | 4 3 4 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Infiltration Cellular, Lipocyte | 1 1 1 1 1 |
Acinus, Atrophy | 1 1 2 2 3 1 2 1 1 2 2|
Acinus, Hyperplasia | 2 |
Perivascular, Inflammation, Chronic | |
Active | 3 4 |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 4 |
Diverticulum | |
Hyperkeratosis | 3 |
Inflammation, Chronic Active | 2 4 3 |
Mineralization | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 7| 2| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 7| 2| 4| 4| 6| 3| 2| 6| 6|
DAY ON TEST | 2| 6| 3| 7| 3| 7| 3| 7| 3| 3| 9| 9| 3| 6| 5| 3| 2| 7| 3| 3| 5| 3| 7| 8| 8|
| 9| 6| 0| 5| 0| 6| 0| 7| 1| 7| 4| 0| 1| 6| 9| 1| 3| 6| 7| 7| 8| 3| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 |
Inflammation, Chronic Active | 3 3 |
Mineralization | 3 3 3 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Mineralization | 4 4 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 3 2 3 2 3 2 1 2 2 3 3 1 2 2|
Mineralization | 2 2 2 |
Atrium, Thrombosis | X |
Valve, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 1 1 1 3 2 3 1 1 2|
Hyperplasia | 2 2 1 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + +|
Hyperplasia | 4 4 3 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 2 3 2 2 1 |
Pars Intermedia, Cyst | |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 7| 2| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 7| 2| 4| 4| 6| 3| 2| 6| 6|
DAY ON TEST | 2| 6| 3| 7| 3| 7| 3| 7| 3| 3| 9| 9| 3| 6| 5| 3| 2| 7| 3| 3| 5| 3| 7| 8| 8|
| 9| 6| 0| 5| 0| 6| 0| 7| 1| 7| 4| 0| 1| 6| 9| 1| 3| 6| 7| 7| 8| 3| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 2 2 3 1 2 2 2 1 3 2 3 2 2 1 2 3|
Mineralization | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 1 1 1 2 1 2 3 2 2|
Interstitial Cell, Hyperplasia | 1 1 2 2 |
Seminiferous Tubule, Atrophy | 3 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + M + + + + + + + + M + M +|
Leukocytosis | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + +|
Cyst | X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 2 |
Infiltration Cellular, Lipocyte | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Thymus | M + + + + M + + + + + + + + + + + +|
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + M + + M + M +|
Hyperplasia, Cystic | 2 4 2 4 3 2 1 2 2 4 2 1 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Alopecia | |
Cyst Epithelial Inclusion | |
Inflammation, Chronic Active | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 7| 2| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 7| 2| 4| 4| 6| 3| 2| 6| 6|
DAY ON TEST | 2| 6| 3| 7| 3| 7| 3| 7| 3| 3| 9| 9| 3| 6| 5| 3| 2| 7| 3| 3| 5| 3| 7| 8| 8|
| 9| 6| 0| 5| 0| 6| 0| 7| 1| 7| 4| 0| 1| 6| 9| 1| 3| 6| 7| 7| 8| 3| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Femur, Fibrous Osteodystrophy | X X X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 2 2 1 2 |
Leukocytosis | X |
Metaplasia, Osseous | 1 |
Mineralization | 2 3 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 2 |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Fungus | X X|
Inflammation, Chronic Active | 1 2 3 3 3|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 2 1 1 1 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | |
Lens, Cataract | 4 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 3 1 3 1 3 4 3 2 4 2 3 3 2 3 4 1 2 2 3 1 3 3|
Glomerulus, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 2| 7| 2| 7| 6| 7| 4| 6| 6| 7| 6| 6| 7| 7| 2| 4| 4| 6| 3| 2| 6| 6|
DAY ON TEST | 2| 6| 3| 7| 3| 7| 3| 7| 3| 3| 9| 9| 3| 6| 5| 3| 2| 7| 3| 3| 5| 3| 7| 8| 8|
| 9| 6| 0| 5| 0| 6| 0| 7| 1| 7| 4| 0| 1| 6| 9| 1| 3| 6| 7| 7| 8| 3| 5| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1500 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia | |
Renal Tubule, Hyperplasia, Oncocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 2| 7| 5| 1| 7| 7| 2| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 2| | |
DAY ON TEST | 7| 2| 9| 2| 3| 3| 7| 3| 1| 8| 1| 2| 2| 3| 3| 4| 3| 3| 3| 7| | |
| 6| 6| 0| 4| 1| 2| 5| 2| 7| 3| 3| 6| 6| 7| 7| 6| 2| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + | 52 |
Mineralization | | 1 3.0|
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + | 52 |
Inflammation, Chronic Active | | 1 3.0|
Parasite Metazoan | X | 3 |
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + | 53 |
Basophilic Focus | X X X X | 9 |
Clear Cell Focus | X X | 5 |
Degeneration, Cystic | 2 3 2 1 1 | 19 1.6|
Hepatodiaphragmatic Nodule | | 3 |
Hyperplasia | 3 | 2 3.5|
Inflammation, Chronic | 1 1 1 1 1 1 1 1 | 30 1.2|
Leukocytosis | | 2 |
Necrosis, Coagulative | | 4 2.8|
Vacuolization Cytoplasmic | 1 2 1 1 1 1 | 23 2.0|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 3 3 3 1 3 1 1 | 50 2.2|
__________________________________________________________________________|____________|
Mesentery | + + | 9 |
Inflammation, Necrotizing | | 6 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + | 51 |
Ectopic Tissue | | 1 |
Infiltration Cellular, Lipocyte | 2 1 1 1 1 | 13 1.2|
Acinus, Atrophy | 2 1 2 1 2 3 2 2 2 1 | 28 1.7|
Acinus, Hyperplasia | | 1 2.0|
Perivascular, Inflammation, Chronic | | |
Active | | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + | 54 |
Acanthosis | 3 2 | 12 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 2| 7| 5| 1| 7| 7| 2| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 2| | |
DAY ON TEST | 7| 2| 9| 2| 3| 3| 7| 3| 1| 8| 1| 2| 2| 3| 3| 4| 3| 3| 3| 7| | |
| 6| 6| 0| 4| 1| 2| 5| 2| 7| 3| 3| 6| 6| 7| 7| 6| 2| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Diverticulum | | 1 2.0|
Hyperkeratosis | | 3 2.7|
Inflammation, Chronic Active | 4 | 8 3.5|
Mineralization | 3 | 4 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + | 52 |
Erosion | | 2 1.5|
Inflammation, Chronic Active | 3 2 | 8 2.8|
Mineralization | 3 3 3 3 | 13 2.7|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | | 1 3.0|
Mineralization | 4 4 4 4 | 10 3.9|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + | 52 |
Cardiomyopathy, Chronic | 3 2 2 2 2 2 3 3 2 2 1 2 3 2 | 48 2.2|
Mineralization | 1 2 1 | 8 2.0|
Atrium, Thrombosis | X X | 5 |
Valve, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + | 52 |
Degeneration, Fatty | 1 2 3 1 3 2 2 | 27 1.9|
Hyperplasia | 2 2 2 2 2 | 14 1.8|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + | 52 |
Hyperplasia | 1 2 2 2 2 1 2 2 | 23 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + | 51 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + | 47 |
Hyperplasia | 3 2 3 3 | 14 2.9|
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + + | 50 |
Craniopharyngeal Duct, Cyst | X | 1 |
Pars Distalis, Cyst | X X X | 7 |
Pars Distalis, Hyperplasia | 2 1 1 2 | 15 1.8|
Pars Intermedia, Cyst | X | 2 |
Pars Nervosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + M + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 2| 7| 5| 1| 7| 7| 2| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 2| | |
DAY ON TEST | 7| 2| 9| 2| 3| 3| 7| 3| 1| 8| 1| 2| 2| 3| 3| 4| 3| 3| 3| 7| | |
| 6| 6| 0| 4| 1| 2| 5| 2| 7| 3| 3| 6| 6| 7| 7| 6| 2| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 1 1 2 1 2 | 12 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 3 |
Inflammation, Chronic Active | | 2 3.5|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + | 53 |
Hyperplasia | 3 4 | 3 3.3|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 | 50 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + | 52 |
Cyst | X X | 2 |
Inflammation, Chronic Active | 2 2 2 1 1 2 1 3 | 38 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + | 54 |
Mineralization | 1 1 2 2 1 1 1 1 1 | 31 1.4|
Interstitial Cell, Hyperplasia | 2 1 1 1 2 | 15 1.4|
Seminiferous Tubule, Atrophy | | 5 3.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | M + + + + + + + + + + + M + + | 42 |
Leukocytosis | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + | 52 |
Femoral, Myelofibrosis | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + | 52 |
Renal, Hyperplasia, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + | 48 |
Cyst | X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 52 |
Fibrosis | 3 | 6 2.5|
Hematopoietic Cell Proliferation | 2 | 4 2.3|
Infiltration Cellular, Lipocyte | | 1 2.0|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 2| 7| 5| 1| 7| 7| 2| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 2| | |
DAY ON TEST | 7| 2| 9| 2| 3| 3| 7| 3| 1| 8| 1| 2| 2| 3| 3| 4| 3| 3| 3| 7| | |
| 6| 6| 0| 4| 1| 2| 5| 2| 7| 3| 3| 6| 6| 7| 7| 6| 2| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + + + + + + + | 48 |
Ectopic Parathyroid Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M M M + + + + | 39 |
Hyperplasia, Cystic | 1 1 2 1 1 1 2 2 2 2 1 2 | 38 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + | 52 |
Acanthosis | | 1 3.0|
Alopecia | | 1 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic Active | | 4 3.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + | 52 |
Cranium, Fibrous Osteodystrophy | X X X X X | 13 |
Femur, Fibrous Osteodystrophy | X X X X X | 14 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + | 51 |
Compression | | 4 |
Hydrocephalus | 2 | 5 2.2|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
White Matter, Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + | 52 |
Infiltration Cellular, Histiocyte | 1 1 | 18 1.0|
Inflammation, Chronic Active | 3 | 9 2.3|
Leukocytosis | | 1 |
Metaplasia, Osseous | 2 1 | 4 1.3|
Mineralization | 2 3 | 6 2.7|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | 2 | 3 1.7|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + | 51 |
Fungus | X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 2| 7| 5| 1| 7| 7| 2| 7| 7| 6| 6| 7| 7| 4| 4| 3| 5| 7| 7| 2| | |
DAY ON TEST | 7| 2| 9| 2| 3| 3| 7| 3| 1| 8| 1| 2| 2| 3| 3| 4| 3| 3| 3| 7| | |
| 6| 6| 0| 4| 1| 2| 5| 2| 7| 3| 3| 6| 6| 7| 7| 6| 2| 2| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1500 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 3 3 2 | 9 2.4|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 | 16 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic Active | | 1 4.0|
Lens, Cataract | | 1 4.0|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 69 |
Nephropathy, Chronic | 2 4 2 4 3 3 1 3 4 4 3 3 2 1 2 1 2 4 3 1 | 68 2.6|
Glomerulus, Inflammation, Chronic | | |
Active | | 1 2.0|
Renal Tubule, Hyperplasia | 2 3 | 3 2.3|
Renal Tubule, Hyperplasia, Oncocytic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 4| 7| 2| 7| 6| 7| 6| 6| 7| 6| 7| 2| 7| 7| 7| 6| 7| 6| 6| 3| 7|
DAY ON TEST | 2| 3| 2| 6| 3| 2| 7| 3| 1| 2| 0| 3| 3| 9| 3| 7| 1| 3| 1| 5| 0| 5| 3| 8| 3|
| 8| 7| 8| 3| 7| 9| 5| 2| 8| 8| 6| 1| 0| 0| 0| 5| 4| 0| 1| 4| 3| 9| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + M + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1 1 1 1 1 1 2 1 2|
Hepatodiaphragmatic Nodule | |
Inflammation, Chronic | 1 2 1 1 1 1 2 1 1 1|
Leukocytosis | X |
Necrosis, Coagulative | 2 4 |
Thrombosis | X |
Vacuolization Cytoplasmic | 1 1 2 1 1 1 1 2 2 |
Bile Duct, Hyperplasia | 3 2 1 2 1 2 2 1 2 2 2 2 2 2 3 3 2 3 3 2 2|
Hepatocyte, Atrophy | |
__________________________________________________________________________|
Mesentery | + + + +|
Inflammation, Necrotizing | 4 3 4 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 1 1 1 1 1 1 1 1 1 |
Acinus, Atrophy | 2 2 2 2 2 |
Acinus, Hyperplasia | |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 3 2 2 |
Hyperkeratosis | 2 2 2 |
Inflammation, Chronic Active | 4 2 4 |
Mineralization | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic Active | 2 3 3 2 |
Mineralization | 4 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 4| 7| 2| 7| 6| 7| 6| 6| 7| 6| 7| 2| 7| 7| 7| 6| 7| 6| 6| 3| 7|
DAY ON TEST | 2| 3| 2| 6| 3| 2| 7| 3| 1| 2| 0| 3| 3| 9| 3| 7| 1| 3| 1| 5| 0| 5| 3| 8| 3|
| 8| 7| 8| 3| 7| 9| 5| 2| 8| 8| 6| 1| 0| 0| 0| 5| 4| 0| 1| 4| 3| 9| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 4 4 |
Thrombosis | X|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 2 2 3 2 2 3 3 3 3 2 2 3 3 3 2 3 3 3 3 1 2|
Mineralization | 1 2 |
Atrium, Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 1 1 2 2 2 2 1 1 2 2 1 3 2 1|
Hyperplasia | 2 1 2 1 1 1 1 |
Hypertrophy | 2 |
Necrosis, Coagulative | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 2 2 1 2 2 3 2 2 2 1 2 1 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 1 1 2 2 2 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 1 1 |
Follicle, Cyst Multilocular | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 4| 7| 2| 7| 6| 7| 6| 6| 7| 6| 7| 2| 7| 7| 7| 6| 7| 6| 6| 3| 7|
DAY ON TEST | 2| 3| 2| 6| 3| 2| 7| 3| 1| 2| 0| 3| 3| 9| 3| 7| 1| 3| 1| 5| 0| 5| 3| 8| 3|
| 8| 7| 8| 3| 7| 9| 5| 2| 8| 8| 6| 1| 0| 0| 0| 5| 4| 0| 1| 4| 3| 9| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 1 2 2 3 2 2 2 3 2 2 2 2 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X|
Inflammation, Chronic Active | 2 2 2 1 3 1 2 2 3 1 2 2 3 2 1 1 1 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 3 1 1 2 1 1|
Interstitial Cell, Hyperplasia | 1 1 2 1 2 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + M + + + M M + + + + M + + + + + + + +|
Leukocytosis | X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Femoral, Atrophy | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Plasma Cell| 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hyperplasia, Plasma Cell | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 3 |
Necrosis, Coagulative | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + M M + + + + + + + + + + + M + M|
Hyperplasia, Cystic | 2 2 1 2 2 2 3 2 3 1 2 2 3 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Alopecia | X |
Inflammation, Chronic Active | 4 4 |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X X |
Femur, Fibrous Osteodystrophy | X X X X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 5| 4| 5| 6| 4| 7| 2| 7| 6| 7| 6| 6| 7| 6| 7| 2| 7| 7| 7| 6| 7| 6| 6| 3| 7|
DAY ON TEST | 2| 3| 2| 6| 3| 2| 7| 3| 1| 2| 0| 3| 3| 9| 3| 7| 1| 3| 1| 5| 0| 5| 3| 8| 3|
| 8| 7| 8| 3| 7| 9| 5| 2| 8| 8| 6| 1| 0| 0| 0| 5| 4| 0| 1| 4| 3| 9| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 2 2 3 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation, Chronic Active | 2 3 1 2 |
Leukocytosis | X |
Metaplasia, Osseous | |
Mineralization | 3 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 2 4 2 3 1 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cornea, Inflammation, Chronic Active | 2 1 2 |
Cornea, Mineralization | 2 1 |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 4 |
Nephropathy, Chronic | 2 1 2 4 2 3 1 3 3 4 4 4 3 4 3 1 2 3 2 2 3 2 3 1 3|
Thrombosis | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 4| 4| 4| 6| 5| 7| 4| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 7| 2| 7| 2| 7| 3| 0| 2| 1| 3| 3| 3| 3| 8| 8| 5| 3| 3| 9| 3| 3| 3| 3| 3| 1|
| 6| 7| 6| 9| 5| 0| 1| 9| 7| 1| 7| 7| 7| 1| 4| 7| 0| 7| 9| 7| 1| 1| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Clear Cell Focus | X |
Degeneration, Cystic | 3 2 1 1 2 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic | 2 1 1 1 3 1 1 1|
Leukocytosis | X |
Necrosis, Coagulative | 3 1 |
Thrombosis | |
Vacuolization Cytoplasmic | 1 1 2 1 1 2 4 1 1 |
Bile Duct, Hyperplasia | 2 2 1 3 2 2 2 2 2 2 2 2 3 2 2 1|
Hepatocyte, Atrophy | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 1 1 2 1 1 1 2 1|
Acinus, Atrophy | 2 2 2 1 2 3 1 3 1|
Acinus, Hyperplasia | |
Perivascular, Inflammation, Chronic | |
Active | 3 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2|
Hyperkeratosis | 2 |
Inflammation, Chronic Active | 4 2 |
Mineralization | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic Active | 2 |
Mineralization | 3 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 4| 4| 4| 6| 5| 7| 4| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 7| 2| 7| 2| 7| 3| 0| 2| 1| 3| 3| 3| 3| 8| 8| 5| 3| 3| 9| 3| 3| 3| 3| 3| 1|
| 6| 7| 6| 9| 5| 0| 1| 9| 7| 1| 7| 7| 7| 1| 4| 7| 0| 7| 9| 7| 1| 1| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Mineralization | 4 4 4 |
Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 3 2 2 3 1 2 1 4 1 2 2 2 2 2 3 2|
Mineralization | 3 2 4 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 1 1 2 2 3 1 2 1|
Hyperplasia | 2 1 1 2 3 |
Hypertrophy | |
Necrosis, Coagulative | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 2 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + M|
Hyperplasia | 3 3 3 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + +|
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 2 3 2 1 1 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 2 1 2|
Follicle, Cyst Multilocular | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 4| 4| 4| 6| 5| 7| 4| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 7| 2| 7| 2| 7| 3| 0| 2| 1| 3| 3| 3| 3| 8| 8| 5| 3| 3| 9| 3| 3| 3| 3| 3| 1|
| 6| 7| 6| 9| 5| 0| 1| 9| 7| 1| 7| 7| 7| 1| 4| 7| 0| 7| 9| 7| 1| 1| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 2 2 2 2 2 2 2 2 2 1 3 2 2 2 3 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic Active | 1 1 1 1 3 1 2 4 3 3 2 2 2 1 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 2 2 2 1 1 1 1 |
Interstitial Cell, Hyperplasia | 1 1|
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + M + + + + + + M + + + + +|
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
Femoral, Atrophy | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Fibrosis | 3 4 3 3 |
Hematopoietic Cell Proliferation | 3 3 |
Necrosis, Coagulative | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + M M + + + + + M M + + + + M|
Hyperplasia, Cystic | 2 2 2 2 1 4 4 3 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + M + + + + + +|
Alopecia | |
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X X X |
Femur, Fibrous Osteodystrophy | X X X X X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 2| 7| 7| 7| 4| 7| 4| 4| 4| 4| 6| 5| 7| 4| 4| 4| 7| 7| 7| 7| 5|
DAY ON TEST | 7| 2| 7| 2| 7| 3| 0| 2| 1| 3| 3| 3| 3| 8| 8| 5| 3| 3| 9| 3| 3| 3| 3| 3| 1|
| 6| 7| 6| 9| 5| 0| 1| 9| 7| 1| 7| 7| 7| 1| 4| 7| 0| 7| 9| 7| 1| 1| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Compression | X X X X |
Hydrocephalus | 2 2 2 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation, Chronic Active | 3 3 3 2 |
Leukocytosis | X |
Metaplasia, Osseous | |
Mineralization | 3 4 2 |
Alveolar Epithelium, Hyperplasia | 3 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 2 2 1 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cornea, Inflammation, Chronic Active | |
Cornea, Mineralization | 2 |
Lens, Cataract | 4 4 |
Retina, Atrophy | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Nephropathy, Chronic | 1 4 1 4 1 3 3 4 3 3 1 2 2 2 4 3 4 2 2 2 3 3 3 3 2|
Thrombosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 2| 7| 2| 5| 2| 4| 6| 7| 2| 7| 7| 7| 7| 4| 2| 6| 7| | |
DAY ON TEST | 2| 0| 9| 7| 3| 7| 8| 7| 3| 2| 3| 7| 3| 3| 1| 3| 3| 7| 1| 3| | |
| 9| 9| 8| 6| 1| 5| 2| 6| 7| 1| 2| 6| 2| 2| 5| 2| 7| 5| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + M + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + | 50 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + | 51 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | | 1 3.0|
Lymphoid Tissue, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 52 |
Basophilic Focus | X X | 10 |
Clear Cell Focus | | 3 |
Degeneration, Cystic | 1 3 1 1 | 19 1.4|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic | 2 2 2 1 1 1 1 | 25 1.3|
Leukocytosis | | 2 |
Necrosis, Coagulative | | 4 2.5|
Thrombosis | | 1 |
Vacuolization Cytoplasmic | 3 1 1 3 2 3 | 24 1.6|
Bile Duct, Hyperplasia | 2 1 3 3 2 1 3 3 2 3 2 | 48 2.1|
Hepatocyte, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Inflammation, Necrotizing | | 5 3.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + | 51 |
Infiltration Cellular, Lipocyte | 1 1 1 1 1 1 1 1 | 25 1.1|
Acinus, Atrophy | 3 1 1 1 | 18 1.8|
Acinus, Hyperplasia | 3 | 1 3.0|
Perivascular, Inflammation, Chronic | | |
Active | | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 52 |
Acanthosis | 3 3 2 | 11 2.5|
Hyperkeratosis | 3 2 | 6 2.2|
Inflammation, Chronic Active | 4 4 4 | 8 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 2| 7| 2| 5| 2| 4| 6| 7| 2| 7| 7| 7| 7| 4| 2| 6| 7| | |
DAY ON TEST | 2| 0| 9| 7| 3| 7| 8| 7| 3| 2| 3| 7| 3| 3| 1| 3| 3| 7| 1| 3| | |
| 9| 9| 8| 6| 1| 5| 2| 6| 7| 1| 2| 6| 2| 2| 5| 2| 7| 5| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + | 52 |
Erosion | | 1 2.0|
Inflammation, Chronic Active | 3 2 2 | 8 2.4|
Mineralization | 2 | 9 2.6|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | | 1 3.0|
Mineralization | 3 | 6 3.8|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + | 51 |
Cardiomyopathy, Chronic | 2 2 3 3 2 3 2 3 2 2 2 2 2 | 51 2.4|
Mineralization | | 5 2.4|
Atrium, Thrombosis | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + | 51 |
Degeneration, Fatty | 1 2 1 1 2 3 | 32 1.6|
Hyperplasia | 1 1 1 2 2 | 17 1.5|
Hypertrophy | 2 | 2 2.0|
Necrosis, Coagulative | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + | 51 |
Atrophy | 4 | 1 4.0|
Hyperplasia | 2 1 1 1 2 2 2 2 2 2 | 31 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 51 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + | 49 |
Hyperplasia | 3 2 | 12 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + | 51 |
Craniopharyngeal Duct, Cyst | X | 1 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 3 | 18 1.8|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 51 |
C-Cell, Hyperplasia | 2 1 | 15 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 2| 7| 2| 5| 2| 4| 6| 7| 2| 7| 7| 7| 7| 4| 2| 6| 7| | |
DAY ON TEST | 2| 0| 9| 7| 3| 7| 8| 7| 3| 2| 3| 7| 3| 3| 1| 3| 3| 7| 1| 3| | |
| 9| 9| 8| 6| 1| 5| 2| 6| 7| 1| 2| 6| 2| 2| 5| 2| 7| 5| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicle, Cyst Multilocular | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + | 51 |
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + | 52 |
Inflammation, Chronic Active | 2 1 2 2 2 2 2 1 2 2 2 2 | 45 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + | 51 |
Cyst | | 1 |
Inflammation, Chronic Active | 1 3 2 3 2 1 3 1 2 2 | 44 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + | 51 |
Mineralization | 1 1 1 1 1 | 22 1.4|
Interstitial Cell, Hyperplasia | 2 1 1 | 10 1.3|
Seminiferous Tubule, Atrophy | 2 | 3 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + M + + + + + + + | 44 |
Leukocytosis | X | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 51 |
Femoral, Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 51 |
Mediastinal, Hyperplasia, Plasma Cell| | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + | 51 |
Cyst | | 3 |
Hyperplasia, Plasma Cell | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + | 51 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 51 |
Fibrosis | 2 | 7 2.7|
Hematopoietic Cell Proliferation | 2 | 4 2.8|
Necrosis, Coagulative | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 2| 7| 2| 5| 2| 4| 6| 7| 2| 7| 7| 7| 7| 4| 2| 6| 7| | |
DAY ON TEST | 2| 0| 9| 7| 3| 7| 8| 7| 3| 2| 3| 7| 3| 3| 1| 3| 3| 7| 1| 3| | |
| 9| 9| 8| 6| 1| 5| 2| 6| 7| 1| 2| 6| 2| 2| 5| 2| 7| 5| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + M + M + + M + + + | 36 |
Hyperplasia, Cystic | 1 2 2 2 1 1 2 1 2 | 36 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + | 50 |
Alopecia | | 1 |
Inflammation, Chronic Active | 2 | 3 3.3|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 51 |
Cranium, Fibrous Osteodystrophy | X X | 11 |
Femur, Fibrous Osteodystrophy | X X X | 12 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 51 |
Compression | X | 7 |
Hydrocephalus | 3 | 8 2.3|
Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 51 |
Infiltration Cellular, Histiocyte | 1 1 1 | 9 1.0|
Inflammation, Chronic Active | 3 | 9 2.4|
Leukocytosis | | 2 |
Metaplasia, Osseous | 1 1 | 2 1.0|
Mineralization | 2 | 6 2.5|
Alveolar Epithelium, Hyperplasia | 2 1 | 5 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 51 |
Inflammation, Chronic Active | 3 2 | 7 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 2 | 18 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 6 |
Cornea, Inflammation, Chronic Active | | 3 1.7|
Cornea, Mineralization | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 2| 7| 2| 5| 2| 4| 6| 7| 2| 7| 7| 7| 7| 4| 2| 6| 7| | |
DAY ON TEST | 2| 0| 9| 7| 3| 7| 8| 7| 3| 2| 3| 7| 3| 3| 1| 3| 3| 7| 1| 3| | |
| 9| 9| 8| 6| 1| 5| 2| 6| 7| 1| 2| 6| 2| 2| 5| 2| 7| 5| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
5000 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Lens, Cataract | | 2 4.0|
Retina, Atrophy | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Infarct | | 1 4.0|
Nephropathy, Chronic | 4 4 4 2 3 1 3 1 2 3 3 1 3 3 3 3 3 1 2 3 | 70 2.6|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + | 51 |
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 7| 6| 2| 6| 7| 6| 4| 6| 6| 7| 2| 5| 6| 4| 7| 4| 6| 2| 6| 2| 4| 6| 2| 6|
DAY ON TEST | 9| 3| 6| 7| 7| 3| 6| 9| 1| 3| 2| 7| 2| 8| 3| 3| 3| 3| 7| 3| 7| 3| 2| 7| 8|
| 1| 0| 0| 6| 3| 0| 0| 8| 8| 2| 6| 6| 7| 4| 7| 1| 7| 8| 5| 8| 5| 7| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 2 2 2 1 1 |
Hepatodiaphragmatic Nodule | |
Hyperplasia | 4 4 |
Inflammation, Chronic | 2 1 1 2 1 1 1 2 1|
Necrosis, Coagulative | 2 |
Thrombosis | X |
Vacuolization Cytoplasmic | 1 2 1 4 1 1 2|
Bile Duct, Hyperplasia | 3 3 3 2 3 2 2 3 2 1 2 3 2 2 2 3 1|
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Necrotizing | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infiltration Cellular, Lipocyte | 1 1 1|
Acinus, Atrophy | 2 1 2 1 1 1 1 1 1 1 |
Perivascular, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 2 3 2 3 |
Hyperkeratosis | 2 2 |
Inflammation, Chronic Active | 4 2 3 3 3 |
Mineralization | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 |
Mineralization | 4 2 2 2 3 4|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 7| 6| 2| 6| 7| 6| 4| 6| 6| 7| 2| 5| 6| 4| 7| 4| 6| 2| 6| 2| 4| 6| 2| 6|
DAY ON TEST | 9| 3| 6| 7| 7| 3| 6| 9| 1| 3| 2| 7| 2| 8| 3| 3| 3| 3| 7| 3| 7| 3| 2| 7| 8|
| 1| 0| 0| 6| 3| 0| 0| 8| 8| 2| 6| 6| 7| 4| 7| 1| 7| 8| 5| 8| 5| 7| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Caries | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 3 2 2 4|
Thrombosis | X |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 3 1 3 1 1 2 2 3 2 2 2 2 2 2 2 3 2 3|
Degeneration, Chronic | 1 2 2 2 |
Mineralization | 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Atypia Cellular | |
Degeneration, Fatty | 2 1 2 2 3 2 1 2 2 |
Hyperplasia | 2 1 2 2 3 2 2 2 |
Hypertrophy | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 1 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + M + + + + + + + + +|
Hyperplasia | 3 2 2 3 2 2 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Mineralization | |
Craniopharyngeal Duct, Cyst | X |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 3 2 2 2 1 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 |
Follicle, Cyst Multilocular | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 7| 6| 2| 6| 7| 6| 4| 6| 6| 7| 2| 5| 6| 4| 7| 4| 6| 2| 6| 2| 4| 6| 2| 6|
DAY ON TEST | 9| 3| 6| 7| 7| 3| 6| 9| 1| 3| 2| 7| 2| 8| 3| 3| 3| 3| 7| 3| 7| 3| 2| 7| 8|
| 1| 0| 0| 6| 3| 0| 0| 8| 8| 2| 6| 6| 7| 4| 7| 1| 7| 8| 5| 8| 5| 7| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Mineralization | 3 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 3 2 2 2 2 1 2 2 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 3 2 1 1 3 2 1 3 1|
Thrombosis | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Mineralization | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Coagulative | 4 |
Interstitial Cell, Hyperplasia | 2 1 1 1 1 1 2 2 2 |
Seminiferous Tubule, Atrophy | 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + M + M + + + + + + + + + + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | |
Thrombosis | |
__________________________________________________________________________|
Thymus | M + + + M + M + + + + + + + + + + + + + + + + M +|
Cyst | |
Ectopic Thyroid | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + M + + + + + M M + + M + + + + M M|
Hyperplasia, Cystic | 1 1 2 2 2 2 1 2 2 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 7| 6| 2| 6| 7| 6| 4| 6| 6| 7| 2| 5| 6| 4| 7| 4| 6| 2| 6| 2| 4| 6| 2| 6|
DAY ON TEST | 9| 3| 6| 7| 7| 3| 6| 9| 1| 3| 2| 7| 2| 8| 3| 3| 3| 3| 7| 3| 7| 3| 2| 7| 8|
| 1| 0| 0| 6| 3| 0| 0| 8| 8| 2| 6| 6| 7| 4| 7| 1| 7| 8| 5| 8| 5| 7| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X X X|
Femur, Fibrous Osteodystrophy | X X X X X X|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X |
Hydrocephalus | 4 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
White Matter, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 |
Inflammation, Chronic Active | 2 2 |
Metaplasia, Osseous | |
Mineralization | 2 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | X |
Inflammation, Chronic Active | 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 1 2 1 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Anterior Chamber, Inflammation, | |
Suppurative | |
Cornea, Inflammation, Chronic Active | 3 |
Cornea, Mineralization | 2 |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 4 3 2 1 2 4 2 2 2 2 4 1 3 3 2 4 2 4 4 1 2 2 2 4|
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 6| 7| 6| 2| 6| 7| 6| 4| 6| 6| 7| 2| 5| 6| 4| 7| 4| 6| 2| 6| 2| 4| 6| 2| 6|
DAY ON TEST | 9| 3| 6| 7| 7| 3| 6| 9| 1| 3| 2| 7| 2| 8| 3| 3| 3| 3| 7| 3| 7| 3| 2| 7| 8|
| 1| 0| 0| 6| 3| 0| 0| 8| 8| 2| 6| 6| 7| 4| 7| 1| 7| 8| 5| 8| 5| 7| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
15000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Thrombosis | |
Renal Tubule, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 6| 2| 6| 6| 4| 6| 4| 6| 5| 2| 7| 7| 2| 4| 7| 6| 6| 2| 7| 7| 4| 6| 3| 5|
DAY ON TEST | 3| 7| 7| 9| 6| 9| 3| 3| 7| 6| 7| 1| 1| 6| 3| 1| 6| 5| 7| 3| 2| 3| 9| 5| 5|
| 7| 0| 6| 0| 3| 8| 1| 7| 7| 8| 6| 9| 1| 8| 7| 3| 1| 2| 5| 1| 6| 7| 8| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
15000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | |
Inflammation, Chronic | 1 1 2 1 1 2 1 1 1 2 1 2 1 |
Necrosis, Coagulative | |
Thrombosis | |
Vacuolization Cytoplasmic | 2 1 1 2 1 3 2 2 |
Bile Duct, Hyperplasia | 1 2 2 2 2 2 1 2 2 2 1 2 2 3|
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Necrotizing | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Cyst | |
Infiltration Cellular, Lipocyte | 1 1 1 1 1 1 |
Acinus, Atrophy | 1 1 1 1 1 1 2|
Perivascular, Inflammation, Chronic | |
Active | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 2 |
Hyperkeratosis | |
Inflammation, Chronic Active | 2 2 |
Mineralization | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 4 4 3 2 3 3 2 2 |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 6| 2| 6| 6| 4| 6| 4| 6| 5| 2| 7| 7| 2| 4| 7| 6| 6| 2| 7| 7| 4| 6| 3| 5|
DAY ON TEST | 3| 7| 7| 9| 6| 9| 3| 3| 7| 6| 7| 1| 1| 6| 3| 1| 6| 5| 7| 3| 2| 3| 9| 5| 5|
| 7| 0| 6| 0| 3| 8| 1| 7| 7| 8| 6| 9| 1| 8| 7| 3| 1| 2| 5| 1| 6| 7| 8| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
15000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Caries | 3 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Mineralization | 4 4 4 4 4 4 4 |
Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Chronic | 1 3 3 3 2 2 3 3 3 3 3 2 3 2 3 1 2 2|
Degeneration, Chronic | 2 |
Mineralization | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Atypia Cellular | |
Degeneration, Fatty | 2 2 1 1 1 2 2 2 1 2 1 1|
Hyperplasia | 2 1 2 2 2|
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 2 2 2 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 3 3 2 3 3 2 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Mineralization | |
Craniopharyngeal Duct, Cyst | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 |
Pars Intermedia, Cyst | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst Multilocular | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 6| 2| 6| 6| 4| 6| 4| 6| 5| 2| 7| 7| 2| 4| 7| 6| 6| 2| 7| 7| 4| 6| 3| 5|
DAY ON TEST | 3| 7| 7| 9| 6| 9| 3| 3| 7| 6| 7| 1| 1| 6| 3| 1| 6| 5| 7| 3| 2| 3| 9| 5| 5|
| 7| 0| 6| 0| 3| 8| 1| 7| 7| 8| 6| 9| 1| 8| 7| 3| 1| 2| 5| 1| 6| 7| 8| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
15000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
Mineralization | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic Active | 1 2 2 1 2 2 1 1 2 2 2 2 2 2 2 2 1 2 1 1 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 1 2 2 3 2 2 2 2 2 2 2 3 2 2 3 1 2|
Thrombosis | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Mineralization | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 2 2 1 1 |
Necrosis, Coagulative | |
Interstitial Cell, Hyperplasia | 1 2 1 2 1 1 2 2 2 1 1 1 2|
Seminiferous Tubule, Atrophy | 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + M M M + M + M + + +|
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pancreatic, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + M + + + + + + +|
Cyst | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + M + + + M + + M + + + + +|
Cyst | |
Ectopic Thyroid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M + + + + + + + + M + + + + + M + M + + M|
Hyperplasia, Cystic | 2 2 2 1 2 1 2 1 2 3 3 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 6| 2| 6| 6| 4| 6| 4| 6| 5| 2| 7| 7| 2| 4| 7| 6| 6| 2| 7| 7| 4| 6| 3| 5|
DAY ON TEST | 3| 7| 7| 9| 6| 9| 3| 3| 7| 6| 7| 1| 1| 6| 3| 1| 6| 5| 7| 3| 2| 3| 9| 5| 5|
| 7| 0| 6| 0| 3| 8| 1| 7| 7| 8| 6| 9| 1| 8| 7| 3| 1| 2| 5| 1| 6| 7| 8| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
15000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Fibrous Osteodystrophy | X X X X X X X X |
Femur, Fibrous Osteodystrophy | X X X X X X X X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | X X |
Hydrocephalus | 3 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
White Matter, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 |
Inflammation, Chronic Active | 2 2 3 |
Metaplasia, Osseous | 2 1 |
Mineralization | 2 2 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Chronic Active | 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 1 2 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + |
Anterior Chamber, Inflammation, | |
Suppurative | 2 |
Cornea, Inflammation, Chronic Active | 2 2 2 |
Cornea, Mineralization | 2 2 3 2 |
Lens, Cataract | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 4 2 4 3 2 3 2 4 4 2 4 4 2 4 2 4 1 3 4 2 3 1 3|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
_____________________________________________________________________________________________________________________
| 4| 6| 2| 6| 6| 4| 6| 4| 6| 5| 2| 7| 7| 2| 4| 7| 6| 6| 2| 7| 7| 4| 6| 3| 5|
DAY ON TEST | 3| 7| 7| 9| 6| 9| 3| 3| 7| 6| 7| 1| 1| 6| 3| 1| 6| 5| 7| 3| 2| 3| 9| 5| 5|
| 7| 0| 6| 0| 3| 8| 1| 7| 7| 8| 6| 9| 1| 8| 7| 3| 1| 2| 5| 1| 6| 7| 8| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
15000 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Thrombosis | |
Renal Tubule, Hyperplasia | 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 2| 7| 7| 6| 7| 2| 6| 7| 7| 7| 4| 7| 6| 7| 6| 6| 2| | |
DAY ON TEST | 1| 2| 3| 7| 0| 2| 8| 0| 7| 3| 1| 1| 3| 3| 3| 6| 1| 3| 5| 7| | |
| 5| 9| 2| 5| 7| 7| 7| 1| 5| 2| 5| 5| 2| 7| 2| 1| 3| 1| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
15000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic Active | | 1 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic Active | 2 | 1 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Basophilic Focus | X X X | 9 |
Clear Cell Focus | X | 3 |
Degeneration, Cystic | 2 2 1 1 2 1 | 12 1.5|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia | | 2 4.0|
Inflammation, Chronic | 2 3 2 2 2 1 1 2 2 | 31 1.5|
Necrosis, Coagulative | | 1 2.0|
Thrombosis | | 1 |
Vacuolization Cytoplasmic | 1 2 1 1 1 3 | 21 1.7|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 3 2 2 2 2 3 | 47 2.1|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Inflammation, Necrotizing | | 5 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 69 |
Cyst | X | 1 |
Infiltration Cellular, Lipocyte | 1 1 1 1 1 | 14 1.0|
Acinus, Atrophy | 3 1 2 2 1 | 22 1.3|
Perivascular, Inflammation, Chronic | | |
Active | 4 4 | 3 3.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Acanthosis | 2 3 | 11 2.4|
Hyperkeratosis | | 2 2.0|
Inflammation, Chronic Active | 3 | 8 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 2| 7| 7| 6| 7| 2| 6| 7| 7| 7| 4| 7| 6| 7| 6| 6| 2| | |
DAY ON TEST | 1| 2| 3| 7| 0| 2| 8| 0| 7| 3| 1| 1| 3| 3| 3| 6| 1| 3| 5| 7| | |
| 5| 9| 2| 5| 7| 7| 7| 1| 5| 2| 5| 5| 2| 7| 2| 1| 3| 1| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
15000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic Active | 1 3 | 4 2.3|
Mineralization | 3 4 3 4 3 3 2 2 4 | 23 3.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + | 59 |
Caries | | 1 3.0|
Inflammation, Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + | 52 |
Inflammation, Chronic Active | 3 | 1 3.0|
Mineralization | 2 4 4 4 4 4 | 17 3.6|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Cardiomyopathy, Chronic | 2 2 3 3 3 3 3 2 2 2 1 2 2 2 3 2 | 52 2.3|
Degeneration, Chronic | 1 | 6 1.7|
Mineralization | 1 1 1 | 9 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Accessory Adrenal Cortical Nodule | | 1 |
Atypia Cellular | X | 1 |
Degeneration, Fatty | 1 2 1 1 1 1 1 | 28 1.5|
Hyperplasia | 2 2 2 2 2 | 18 1.9|
Hypertrophy | 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 1 1 2 2 2 2 2 2 2 2 | 27 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M | 66 |
Hyperplasia | 3 3 2 3 4 3 3 3 | 23 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
Mineralization | 1 | 1 1.0|
Craniopharyngeal Duct, Cyst | X | 2 |
Pars Distalis, Cyst | X X X | 8 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 | 13 2.1|
Pars Intermedia, Cyst | X X X | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 2| 7| 7| 6| 7| 2| 6| 7| 7| 7| 4| 7| 6| 7| 6| 6| 2| | |
DAY ON TEST | 1| 2| 3| 7| 0| 2| 8| 0| 7| 3| 1| 1| 3| 3| 3| 6| 1| 3| 5| 7| | |
| 5| 9| 2| 5| 7| 7| 7| 1| 5| 2| 5| 5| 2| 7| 2| 1| 3| 1| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
15000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 2 1 | 6 1.3|
Follicle, Cyst Multilocular | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic Active | | 1 3.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Penis | + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | | 2 2.5|
Inflammation, Chronic Active | 3 2 2 2 2 2 2 1 1 2 2 2 2 2 2 1 | 53 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + M | 69 |
Inflammation, Acute | 2 | 2 2.0|
Inflammation, Chronic Active | 2 2 2 3 4 3 2 2 1 1 1 2 2 3 | 48 2.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | | 1 3.0|
Mineralization | 3 | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Mineralization | 1 1 1 1 1 2 2 2 1 2 1 1 | 29 1.2|
Necrosis, Coagulative | | 1 4.0|
Interstitial Cell, Hyperplasia | 1 1 2 2 1 | 27 1.4|
Seminiferous Tubule, Atrophy | 4 2 | 8 3.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + M M + + + + + + + + M M + | 41 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 70 |
Pancreatic, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 |
Cyst | X X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 2| 7| 7| 6| 7| 2| 6| 7| 7| 7| 4| 7| 6| 7| 6| 6| 2| | |
DAY ON TEST | 1| 2| 3| 7| 0| 2| 8| 0| 7| 3| 1| 1| 3| 3| 3| 6| 1| 3| 5| 7| | |
| 5| 9| 2| 5| 7| 7| 7| 1| 5| 2| 5| 5| 2| 7| 2| 1| 3| 1| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
15000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Fibrosis | | 3 2.7|
Hematopoietic Cell Proliferation | | 1 3.0|
Thrombosis | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 62 |
Cyst | X | 1 |
Ectopic Thyroid | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + M + + + + + + M + + + + M + + | 53 |
Hyperplasia, Cystic | 2 2 1 2 2 2 1 2 1 2 2 2 2 | 39 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperkeratosis | 4 | 2 4.0|
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Cranium, Fibrous Osteodystrophy | X X X X X X X X X X | 23 |
Femur, Fibrous Osteodystrophy | X X X X X X X X X X | 24 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + | 52 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Compression | X | 4 |
Hydrocephalus | 2 | 5 2.6|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
White Matter, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 1 | 11 1.0|
Inflammation, Chronic Active | 2 2 2 | 8 2.1|
Metaplasia, Osseous | 1 | 3 1.3|
Mineralization | 2 3 2 2 2 2 | 10 2.2|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05085-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC MANGANESE SULFATE Date: 04/24/97
Route: DOSED FEED Time: 17:39:29
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 2| 7| 7| 6| 7| 2| 6| 7| 7| 7| 4| 7| 6| 7| 6| 6| 2| | |
DAY ON TEST | 1| 2| 3| 7| 0| 2| 8| 0| 7| 3| 1| 1| 3| 3| 3| 6| 1| 3| 5| 7| | |
| 5| 9| 2| 5| 7| 7| 7| 1| 5| 2| 5| 5| 2| 7| 2| 1| 3| 1| 5| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
15000 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
PPM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fungus | | 1 |
Inflammation, Chronic Active | 1 3 2 2 2 | 11 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 1 2 | 17 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 10 |
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 2.0|
Cornea, Inflammation, Chronic Active | 2 | 5 2.2|
Cornea, Mineralization | 1 | 6 2.0|
Lens, Cataract | 4 | 2 3.5|
Retina, Atrophy | 4 | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Nephropathy, Chronic | 3 3 4 1 4 4 4 4 1 4 4 4 3 2 3 4 4 3 3 1 | 68 2.9|
Thrombosis | X | 1 |
Renal Tubule, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
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---------- END OF REPORT ----------
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