TDMS Study 05086-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
O-BENZYL-P-CHLOROPHENOL
NTP Experiment-Test: 05086-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/11/94
Route: GAVAGE Time: 09:18:13
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-32-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05086-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 09:18:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 120MG/KG 240MG/KG 480MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 20 18
Early Deaths
Moribund Sacrifice 9 4 10 12
Natural Death 4 3 5 14
Dosing Accident 3 2 1
Survivors
Terminal Sacrifice 36 40 33 25
Natural Death 1
Animals Examined Microscopically 70 70 70 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (70) (50) (50) (70)
Foreign Body 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Small, Duodenum (69) (49) (48) (70)
Inflammation, Chronic 1 (2%)
Ulcer 4 (8%) 8 (11%)
Liver (70) (50) (50) (70)
Foreign Body 1 (1%)
Hyperplasia 3 (4%) 8 (16%) 7 (14%) 4 (6%)
Inflammation, Chronic 1 (2%) 5 (7%)
Inflammation, Necrotizing 6 (9%) 3 (4%)
Necrosis, Coagulative 1 (1%) 3 (6%) 3 (6%) 18 (26%)
Mesentery (5) (8) (2)
Inflammation, Chronic 1 (13%)
Fat, Necrosis 3 (60%) 2 (25%) 1 (50%)
Pancreas (70) (50) (50) (70)
Basophilic Focus 1 (1%)
Inflammation, Chronic 2 (3%) 2 (4%) 2 (4%) 4 (6%)
Necrosis, Coagulative 1 (1%)
Acinus, Atrophy 2 (4%)
Acinus, Hyperplasia 1 (1%) 1 (1%)
Salivary Glands (70) (50) (50) (70)
Ectasia 1 (2%)
Inflammation, Chronic 1 (1%)
Stomach, Forestomach (70) (51) (50) (70)
Hyperplasia, Squamous 3 (4%) 10 (20%) 18 (36%) 22 (31%)
Inflammation, Chronic Active 1 (1%)
Ulcer 2 (3%) 4 (8%) 12 (24%) 13 (19%)
Stomach, Glandular (70) (51) (50) (70)
Inflammation, Chronic 1 (1%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05086-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 09:18:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 120MG/KG 240MG/KG 480MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ulcer 1 (2%) 1 (2%) 1 (1%)
Mucosa, Mineralization 1 (1%) 7 (14%) 10 (20%) 17 (24%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (69) (50) (49) (70)
Artery, Inflammation, Necrotizing 1 (1%)
Atrium, Thrombosis 1 (1%) 1 (2%) 1 (1%)
Myocardium, Degeneration 1 (2%)
Myocardium, Mineralization 2 (4%) 1 (1%)
Valve, Inflammation, Chronic Active 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (70) (50) (50) (70)
Hyperplasia 4 (6%) 4 (8%) 4 (8%) 2 (3%)
Adrenal Gland, Medulla (69) (50) (50) (70)
Hyperplasia 2 (4%) 2 (3%)
Islets, Pancreatic (70) (50) (50) (70)
Hyperplasia 1 (1%) 1 (2%)
Pituitary Gland (67) (50) (47) (67)
Cyst 1 (2%)
Pars Distalis, Hyperplasia 4 (6%) 7 (14%) 4 (9%) 1 (1%)
Pars Intermedia, Hyperplasia 1 (1%)
Thyroid Gland (69) (50) (50) (70)
Inflammation, Chronic 1 (1%)
C-Cell, Hyperplasia 1 (1%)
Follicle, Hyperplasia 8 (12%) 3 (6%) 4 (8%) 3 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1)
Duct, Dilatation 1 (100%)
Ovary (69) (49) (49) (69)
Cyst 19 (28%) 17 (35%) 18 (37%) 13 (19%)
Infarct 2 (3%) 2 (4%) 2 (3%)
Inflammation, Chronic Active 1 (1%)
Inflammation, Suppurative 1 (1%)
Uterus (70) (52) (56) (70)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05086-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 09:18:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 120MG/KG 240MG/KG 480MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 1 (1%)
Dilatation 1 (2%)
Hemorrhage 2 (3%) 1 (2%)
Inflammation, Suppurative 1 (1%) 1 (2%) 1 (1%)
Artery, Inflammation, Chronic Active 1 (2%)
Endometrium, Hyperplasia 44 (63%) 43 (83%) 42 (75%) 32 (46%)
Vagina (1) (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (50) (50) (70)
Myelofibrosis 16 (23%) 3 (6%) 2 (4%)
Lymph Node (69) (50) (48) (70)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mandibular (66) (47) (46) (69)
Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mesenteric (61) (48) (46) (62)
Ectasia 2 (4%)
Infiltration Cellular, Histiocyte 1 (2%)
Spleen (70) (50) (50) (70)
Amyloid Deposition 1 (1%) 1 (2%) 1 (1%)
Depletion Lymphoid 1 (2%) 1 (2%) 8 (11%)
Hematopoietic Cell Proliferation 7 (10%) 3 (6%) 7 (14%) 12 (17%)
Hyperplasia, Lymphoid 9 (13%) 5 (10%) 6 (12%) 12 (17%)
Infiltration Cellular, Histiocyte 1 (1%)
Inflammation, Granulomatous 1 (2%)
Thymus (65) (44) (44) (62)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (70) (50) (50) (69)
Hyperkeratosis 1 (1%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (1%)
Ulcer 1 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05086-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 09:18:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 120MG/KG 240MG/KG 480MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (50) (50) (70)
Fibrous Osteodystrophy 2 (3%) 20 (40%) 33 (66%) 37 (53%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (50) (50) (70)
Cyst Epithelial Inclusion 1 (1%)
Hypothalamus, Compression 1 (1%) 3 (6%) 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (69) (50) (50) (70)
Foreign Body 3 (6%) 2 (4%) 2 (3%)
Inflammation, Chronic 2 (3%) 1 (2%) 2 (4%) 2 (3%)
Thrombosis 1 (2%) 1 (1%)
Alveolus, Infiltration Cellular, Histiocyte 1 (1%)
Nose (70) (50) (50) (70)
Foreign Body 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2)
Phthisis Bulbi 1 (50%)
Cornea, Inflammation, Chronic 1 (50%) 1 (100%) 1 (50%)
Cornea, Inflammation, Necrotizing 1 (50%)
Harderian Gland (5) (3) (3) (3)
Hyperplasia 1 (20%) 1 (33%)
Inflammation, Suppurative 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70) (70) (70)
Amyloid Deposition 1 (1%)
Hydronephrosis 1 (1%)
Nephropathy 19 (27%) 49 (70%) 66 (94%) 66 (94%)
Renal Tubule, Mineralization 1 (1%)
Urinary Bladder (70) (50) (50) (70)
Inflammation 1 (1%)
Inflammation, Necrotizing 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05086-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 09:18:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 120MG/KG 240MG/KG 480MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05086-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 09:18:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 120MG/KG 240MG/KG 480MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 20 20
Early Deaths
Natural Death 3 3 4 10
Moribund Sacrifice 2 12 6 8
Dosing Accident 2 2
Survivors
Terminal Sacrifice 45 32 38 30
Natural Death 1 1
Moribund Sacrifice 1
Animals Examined Microscopically 70 70 70 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (70) (50) (48) (67)
Ulcer 1 (2%) 1 (2%) 2 (3%)
Liver (70) (51) (51) (70)
Cyst 1 (1%) 1 (1%)
Degeneration, Cystic 1 (1%)
Fatty Change 5 (7%)
Hepatodiaphragmatic Nodule 1 (2%)
Hyperplasia 5 (7%) 4 (8%) 5 (10%) 3 (4%)
Inflammation, Chronic 2 (4%) 2 (3%)
Inflammation, Necrotizing 3 (4%) 2 (3%)
Necrosis, Coagulative 4 (6%) 4 (8%) 7 (14%) 5 (7%)
Mesentery (3) (7) (2) (4)
Foreign Body 2 (50%)
Inflammation, Necrotizing 2 (50%)
Fat, Necrosis 2 (67%) 6 (86%) 1 (50%) 1 (25%)
Pancreas (70) (51) (49) (70)
Basophilic Focus 1 (2%)
Cyst 1 (1%)
Inflammation, Chronic 2 (3%) 2 (4%) 2 (4%)
Necrosis 1 (1%)
Salivary Glands (70) (50) (50) (70)
Inflammation, Chronic 1 (2%) 1 (1%)
Stomach, Forestomach (70) (53) (51) (70)
Cyst Epithelial Inclusion 1 (1%)
Hyperplasia, Squamous 4 (6%) 12 (23%) 11 (22%) 10 (14%)
Inflammation, Necrotizing 1 (1%)
Ulcer 1 (1%) 7 (13%) 9 (18%) 6 (9%)
Stomach, Glandular (70) (52) (51) (70)
Inflammation, Suppurative 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05086-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 09:18:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 120MG/KG 240MG/KG 480MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ulcer 1 (1%) 5 (10%) 1 (2%) 1 (1%)
Mucosa, Mineralization 5 (7%) 6 (12%) 13 (25%) 6 (9%)
Tooth (2) (2)
Developmental Malformation 1 (50%)
Inflammation, Chronic Active 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (69) (50) (49) (70)
Bacterium 1 (1%)
Artery, Inflammation, Necrotizing 2 (4%) 2 (4%)
Atrium, Thrombosis 1 (2%) 1 (1%)
Myocardium, Degeneration 5 (10%) 9 (13%)
Myocardium, Mineralization 1 (2%)
Pericardium, Inflammation, Subacute 1 (1%)
Valve, Inflammation, Chronic Active 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (70) (52) (50) (69)
Capsule, Hyperplasia 5 (7%) 1 (2%) 7 (14%) 6 (9%)
Adrenal Gland, Cortex (70) (52) (50) (69)
Degeneration, Fatty, Focal 1 (2%)
Hyperplasia 4 (6%) 17 (33%) 8 (16%) 9 (13%)
Hypertrophy, Focal 5 (7%) 4 (8%) 4 (8%) 4 (6%)
Adrenal Gland, Medulla (69) (52) (49) (68)
Hyperplasia 1 (1%) 2 (3%)
Islets, Pancreatic (70) (50) (49) (69)
Hyperplasia 2 (3%)
Pituitary Gland (64) (48) (47) (65)
Pars Distalis, Hyperplasia 2 (3%) 1 (2%) 3 (6%) 1 (2%)
Thyroid Gland (70) (50) (50) (70)
Follicle, Hyperplasia 5 (7%) 3 (6%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05086-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 09:18:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 120MG/KG 240MG/KG 480MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (17) (23) (15) (1)
Inflammation, Chronic Active 3 (13%) 1 (7%)
Duct, Dilatation 17 (100%) 23 (100%) 14 (93%) 1 (100%)
Seminal Vesicle (70) (50) (48) (70)
Inflammation, Chronic 1 (1%) 1 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (69) (50) (50) (70)
Hyperplasia, Mast Cell 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (69) (50) (48) (69)
Mediastinal, Hyperplasia 1 (2%)
Lymph Node, Mandibular (68) (49) (47) (67)
Hyperplasia, Mast Cell 1 (2%)
Lymph Node, Mesenteric (68) (44) (44) (59)
Ectasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Sinus, Ectasia 2 (5%)
Spleen (70) (50) (49) (70)
Depletion Lymphoid 2 (3%) 2 (4%) 3 (6%) 6 (9%)
Hematopoietic Cell Proliferation 5 (7%) 7 (14%) 2 (4%) 1 (1%)
Hyperplasia, Lymphoid 2 (3%) 1 (2%) 6 (12%)
Inflammation, Chronic 1 (2%)
Thymus (62) (38) (41) (61)
Depletion Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (70) (50) (50) (70)
Edema 1 (1%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (1%)
Hair Follicle, Atrophy 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (50) (50) (70)
Fibrous Osteodystrophy 16 (32%) 25 (50%) 28 (40%)
Hyperostosis 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05086-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 09:18:13
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 120MG/KG 240MG/KG 480MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (52) (50) (70)
Foreign Body 2 (4%) 3 (4%)
Inflammation, Chronic 1 (2%) 3 (4%)
Inflammation, Subacute 1 (1%)
Alveolar Epithelium, Hyperplasia 1 (1%) 1 (1%)
Nose (70) (50) (50) (70)
Foreign Body 1 (2%) 2 (3%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (2)
Cataract 1 (50%)
Phthisis Bulbi 1 (50%) 1 (50%)
Cornea, Inflammation, Chronic 2 (100%) 1 (50%)
Harderian Gland (3) (4) (4) (3)
Hyperplasia 1 (25%) 1 (33%)
Inflammation, Suppurative 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70) (70) (70)
Metaplasia, Osseous 2 (3%)
Nephropathy 49 (70%) 61 (87%) 70 (100%) 69 (99%)
Renal Tubule, Hyperplasia 1 (1%) 4 (6%) 6 (9%)
Renal Tubule, Hyperplasia, Adenomatous 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
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