TDMS Study 05086-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus O-BENZYL-P-CHLOROPHENOL DATE: 09/11/94
EXPERIMENT: 05086 TEST: 02 TIME: 09:32:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45042 ROUTE: GAVAGE NTP C#: 61201C
PATHOLOGIST: M. RYAN CAS: 120-32-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus O-BENZYL-P-CHLOROPHENOL DATE: 09/11/94
EXPERIMENT: 05086 TEST: 02 TIME: 09:32:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45042 ROUTE: GAVAGE NTP C#: 61201C
PATHOLOGIST: M. RYAN CAS: 120-32-1
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus O-BENZYL-P-CHLOROPHENOL DATE: 09/11/94
EXPERIMENT: 05086 TEST: 02 TIME: 09:32:40
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45042 ROUTE: GAVAGE NTP C#: 61201C
PATHOLOGIST: M. RYAN CAS: 120-32-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF O-BENZYL-P-CHLOROPHENOL
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Kidney: Renal Tubule Carcinoma or Adenoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Uterus Polyp Stromal
All Organs Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Malignant and Benign Tumors
====================================================================================================
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Adrenal Gland: Non-medullary, Non-cortical |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 1/70 (1%) 4/70 (6%) 1/69 (1%) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 2.2% 3.0% 10.0% 3.3% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/45 (2%) 1/33 (3%) 4/40 (10%) 1/30 (3%) | 0/37 (0%) 0/40 (0%) 0/33 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 722 (T) 722 (T) 722 (T) 722 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.396 P=0.691 P=0.146 P=0.669 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.396 P=0.691 P=0.146 P=0.669 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.396 P=0.691 P=0.146 P=0.669 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.520 | (e) |
|FISHER EXACT | P=0.752N P=0.183 P=0.748 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 2/70 (3%) 4/70 (6%) 2/70 (3%) | 4/70 (6%) 1/70 (1%) 2/70 (3%) 3/70 (4%) |
|ADJUSTED (b) | 6.4% 6.1% 8.6% 5.2% | 9.5% 2.2% 5.5% 9.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/45 (4%) 2/33 (6%) 2/40 (5%) 0/30 (0%) | 2/37 (5%) 0/40 (0%) 1/33 (3%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 650 722 (T) 433 456 (I) | 605 588 685 658 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.563 P=0.623N P=0.448 P=0.628N | P=0.469 P=0.189N P=0.392N P=0.623 |
|INCIDENTAL TUMOR | P=0.404N P=0.552N P=0.588N P=0.489N | P=0.520N P=0.268N P=0.401N P=0.544N |
|LOGISTIC REGRESSION | P=0.528N P=0.574N P=0.483 P=0.555N | P=0.490N P=0.194N P=0.373N P=0.609N |
|COCHRAN-ARMITAGE | P=0.479N | P=0.543N |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | P=0.183N P=0.340N P=0.500N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 2/70 (3%) 2/70 (3%) 2/70 (3%) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 6.1% 5.0% 6.2% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/45 (0%) 2/33 (6%) 2/40 (5%) 1/30 (3%) | 0/37 (0%) 0/40 (0%) 0/33 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | --- 722 (T) 722 (T) 692 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.156 P=0.173 P=0.213 P=0.162 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.176 P=0.173 P=0.213 P=0.241 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.171 P=0.173 P=0.213 P=0.184 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.243 | (e) |
|FISHER EXACT | P=0.248 P=0.248 P=0.248 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/70 (0%) 2/70 (3%) 1/70 (1%) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 5.0% 3.3% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/45 (0%) 0/33 (0%) 2/40 (5%) 1/30 (3%) | 0/37 (0%) 0/40 (0%) 0/33 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 722 (T) 722 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.179 (e) P=0.213 P=0.419 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.179 (e) P=0.213 P=0.419 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.179 (e) P=0.213 P=0.419 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.246 | (e) |
|FISHER EXACT | (e) P=0.248 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 2/70 (3%) 4/70 (6%) 3/70 (4%) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 6.1% 10.0% 9.4% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/45 (0%) 2/33 (6%) 4/40 (10%) 2/30 (7%) | 0/37 (0%) 0/40 (0%) 0/33 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | --- 722 (T) 722 (T) 692 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.054 P=0.173 P=0.049 * P=0.064 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.062 P=0.173 P=0.049 * P=0.099 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.061 P=0.173 P=0.049 * P=0.077 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.115 | (e) |
|FISHER EXACT | P=0.248 P=0.060 P=0.122 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 0/70 (0%) 1/70 (1%) 2/70 (3%) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 6.7% 0.0% 2.5% 5.3% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 3/45 (7%) 0/33 (0%) 1/40 (3%) 0/30 (0%) | 0/37 (0%) 0/40 (0%) 0/33 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 722 (T) --- 722 (T) 651 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.563 P=0.181N P=0.348N P=0.653N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.610 P=0.181N P=0.348N P=0.526N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.596 P=0.181N P=0.348N P=0.600N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.555N | (e) |
|FISHER EXACT | P=0.122N P=0.310N P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 21/70 (30%) 18/70 (26%) 20/70 (29%) 15/70 (21%) | 11/70 (16%) 14/70 (20%) 15/70 (21%) 14/70 (20%) |
|ADJUSTED (b) | 45.6% 47.6% 41.8% 38.8% | 27.3% 35.0% 42.3% 50.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 1/10 (10%) 2/10 (20%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 20/45 (44%) 14/33 (42%) 13/40 (33%) 9/30 (30%) | 8/37 (22%) 14/40 (35%) 13/33 (39%) 12/25 (48%) |
|FIRST INCIDENCE (DAYS) | 646 455 (I) 433 387 | 694 722 (T) 668 437 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.531N P=0.374 P=0.483 P=0.556 | P=0.030 * P=0.395 P=0.159 P=0.062 |
|INCIDENTAL TUMOR | P=0.187N P=0.565 P=0.393N P=0.222N | P=0.077 P=0.265 P=0.182 P=0.133 |
|LOGISTIC REGRESSION | P=0.321N P=0.565N P=0.551 P=0.355N | P=0.081 P=0.295 P=0.164 P=0.114 |
|COCHRAN-ARMITAGE | P=0.168N | P=0.322 |
|FISHER EXACT | P=0.353N P=0.500N P=0.167N | P=0.330 P=0.257 P=0.330 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/70 (10%) 12/70 (17%) 11/70 (16%) 5/70 (7%) | 2/70 (3%) 1/70 (1%) 3/70 (4%) 3/70 (4%) |
|ADJUSTED (b) | 14.8% 29.7% 23.7% 11.9% | 5.4% 2.5% 8.1% 9.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 5/45 (11%) 5/33 (15%) 6/40 (15%) 0/30 (0%) | 2/37 (5%) 1/40 (3%) 1/33 (3%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 650 650 370 456 (I) | 722 (T) 722 (T) 678 554 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.447N P=0.058 P=0.165 P=0.596N | P=0.167 P=0.473N P=0.455 P=0.346 |
|INCIDENTAL TUMOR | P=0.104N P=0.232 P=0.316 P=0.156N | P=0.282 P=0.473N P=0.488 P=0.413 |
|LOGISTIC REGRESSION | P=0.220N P=0.084 P=0.188 P=0.248N | P=0.219 P=0.473N P=0.459 P=0.411 |
|COCHRAN-ARMITAGE | P=0.223N | P=0.303 |
|FISHER EXACT | P=0.162 P=0.225 P=0.382N | P=0.500N P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/70 (36%) 26/70 (37%) 27/70 (39%) 18/70 (26%) | 13/70 (19%) 15/70 (21%) 17/70 (24%) 16/70 (23%) |
|ADJUSTED (b) | 52.0% 60.1% 53.5% 43.5% | 32.3% 37.5% 46.7% 53.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 1/10 (10%) 2/10 (20%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 22/45 (49%) 16/33 (48%) 17/40 (43%) 9/30 (30%) | 10/37 (27%) 15/40 (38%) 14/33 (42%) 12/25 (48%) |
|FIRST INCIDENCE (DAYS) | 646 455 (I) 370 387 | 694 722 (T) 668 437 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.485N P=0.105 P=0.257 P=0.544 | P=0.021 * P=0.497 P=0.160 P=0.056 |
|INCIDENTAL TUMOR | P=0.063N P=0.403 P=0.565N P=0.106N | P=0.070 P=0.363 P=0.184 P=0.132 |
|LOGISTIC REGRESSION | P=0.233N P=0.247 P=0.315 P=0.316N | P=0.067 P=0.385 P=0.162 P=0.112 |
|COCHRAN-ARMITAGE | P=0.101N | P=0.304 |
|FISHER EXACT | P=0.500 P=0.431 P=0.136N | P=0.416 P=0.269 P=0.339 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 25/70 (36%) 26/70 (37%) 27/70 (39%) 18/70 (26%) | 13/70 (19%) 15/70 (21%) 17/70 (24%) 16/70 (23%) |
|ADJUSTED (b) | 52.0% 60.1% 53.5% 43.5% | 32.3% 37.5% 46.7% 53.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 1/10 (10%) 2/10 (20%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 22/45 (49%) 16/33 (48%) 17/40 (43%) 9/30 (30%) | 10/37 (27%) 15/40 (38%) 14/33 (42%) 12/25 (48%) |
|FIRST INCIDENCE (DAYS) | 646 455 (I) 370 387 | 694 722 (T) 668 437 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.485N P=0.105 P=0.257 P=0.544 | P=0.021 * P=0.497 P=0.160 P=0.056 |
|INCIDENTAL TUMOR | P=0.063N P=0.403 P=0.565N P=0.106N | P=0.070 P=0.363 P=0.184 P=0.132 |
|LOGISTIC REGRESSION | P=0.233N P=0.247 P=0.315 P=0.316N | P=0.067 P=0.385 P=0.162 P=0.112 |
|COCHRAN-ARMITAGE | P=0.101N | P=0.304 |
|FISHER EXACT | P=0.500 P=0.431 P=0.136N | P=0.416 P=0.269 P=0.339 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/70 (19%) 12/70 (17%) 6/70 (9%) 6/70 (9%) | 3/69 (4%) 1/70 (1%) 0/70 (0%) 4/70 (6%) |
|ADJUSTED (b) | 27.3% 30.9% 15.0% 16.7% | 7.4% 2.5% 0.0% 10.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 2/10 (20%) 0/10 (0%) 2/10 (20%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 11/45 (24%) 8/33 (24%) 6/40 (15%) 4/30 (13%) | 2/36 (6%) 1/40 (3%) 0/33 (0%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 456 (I) 722 (T) 455 (I) | 560 722 (T) --- 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.102N P=0.390 P=0.106N P=0.235N | P=0.209 P=0.286N P=0.140N P=0.364 |
|INCIDENTAL TUMOR | P=0.075N P=0.569 P=0.115N P=0.204N | P=0.353 P=0.303N P=0.175N P=0.569 |
|LOGISTIC REGRESSION | P=0.057N P=0.560 P=0.095N P=0.130N | P=0.289 P=0.316N P=0.129N P=0.474 |
|COCHRAN-ARMITAGE | P=0.030N* | P=0.318 |
|FISHER EXACT | P=0.500N P=0.069N P=0.069N | P=0.304N P=0.120N P=0.508 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 3/70 (4%) 1/70 (1%) 1/70 (1%) | 2/69 (3%) 2/70 (3%) 1/70 (1%) 1/70 (1%) |
|ADJUSTED (b) | 4.4% 8.6% 2.2% 3.3% | 5.0% 5.0% 3.0% 4.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/45 (4%) 2/33 (6%) 0/40 (0%) 1/30 (3%) | 1/36 (3%) 2/40 (5%) 1/33 (3%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 722 (T) 687 588 722 (T) | 694 722 (T) 722 (T) 722 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.383N P=0.366 P=0.537N P=0.640N | P=0.471N P=0.669N P=0.537N P=0.625N |
|INCIDENTAL TUMOR | P=0.280N P=0.448 P=0.265N P=0.640N | P=0.417N P=0.635 P=0.508N P=0.561N |
|LOGISTIC REGRESSION | P=0.342N P=0.411 P=0.519N P=0.640N | P=0.435N P=0.689 P=0.524N P=0.595N |
|COCHRAN-ARMITAGE | P=0.280N | P=0.334N |
|FISHER EXACT | P=0.500 P=0.500N P=0.500N | P=0.685N P=0.495N P=0.495N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/70 (21%) 15/70 (21%) 7/70 (10%) 7/70 (10%) | 5/69 (7%) 3/70 (4%) 1/70 (1%) 5/70 (7%) |
|ADJUSTED (b) | 31.6% 38.2% 16.8% 19.9% | 12.3% 7.5% 3.0% 14.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 2/10 (20%) 0/10 (0%) 2/10 (20%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 13/45 (29%) 10/33 (30%) 6/40 (15%) 5/30 (17%) | 3/36 (8%) 3/40 (8%) 1/33 (3%) 2/25 (8%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 456 (I) 588 455 (I) | 560 722 (T) 722 (T) 455 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.077N P=0.265 P=0.086N P=0.217N | P=0.350 P=0.325N P=0.131N P=0.443 |
|INCIDENTAL TUMOR | P=0.043N* P=0.453 P=0.053N P=0.189N | P=0.517 P=0.402N P=0.143N P=0.617N |
|LOGISTIC REGRESSION | P=0.038N* P=0.439 P=0.072N P=0.111N | P=0.466 P=0.374N P=0.117N P=0.570 |
|COCHRAN-ARMITAGE | P=0.017N* | P=0.543 |
|FISHER EXACT | P=0.581N P=0.051N P=0.051N | P=0.351N P=0.101N P=0.619N |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/69 (3%) 0/69 (0%) 0/69 (0%) 0/69 (0%) |
|ADJUSTED (b) | | 5.6% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | | 2/36 (6%) 0/39 (0%) 0/33 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | | 722 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.143N P=0.221N P=0.258N P=0.322N |
|INCIDENTAL TUMOR | | P=0.143N P=0.221N P=0.258N P=0.322N |
|LOGISTIC REGRESSION | | P=0.143N P=0.221N P=0.258N P=0.322N |
|COCHRAN-ARMITAGE | | P=0.115N |
|FISHER EXACT | | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/67 (0%) 0/68 (0%) 0/67 (0%) 0/66 (0%) | 8/67 (12%) 4/70 (6%) 5/67 (7%) 1/67 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 21.3% 10.0% 15.1% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/42 (0%) 0/32 (0%) 0/38 (0%) 0/30 (0%) | 7/36 (19%) 4/40 (10%) 4/32 (13%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 692 722 (T) 714 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.061N P=0.136N P=0.358N P=0.060N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.039N* P=0.165N P=0.330N P=0.039N* |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.045N* P=0.164N P=0.343N P=0.043N* |
|COCHRAN-ARMITAGE | (e) | P=0.020N* |
|FISHER EXACT | (e) (e) (e) | P=0.162N P=0.281N P=0.016N* |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 1/70 (1%) | 3/70 (4%) 0/70 (0%) 0/70 (0%) 1/70 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 3.3% | 6.9% 0.0% 0.0% 4.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/45 (0%) 0/33 (0%) 0/40 (0%) 1/30 (3%) | 0/37 (0%) 0/40 (0%) 0/33 (0%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 722 (T) | 645 --- --- 722 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.161 (e) (e) P=0.419 | P=0.324N P=0.131N P=0.142N P=0.428N |
|INCIDENTAL TUMOR | P=0.161 (e) (e) P=0.419 | P=0.191N P=0.356N P=0.093N P=0.280N |
|LOGISTIC REGRESSION | P=0.160 (e) (e) P=0.419 | P=0.294N P=0.130N P=0.134N P=0.387N |
|COCHRAN-ARMITAGE | P=0.199 | P=0.248N |
|FISHER EXACT | (e) (e) P=0.500 | P=0.122N P=0.122N P=0.310N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 2/70 (3%) 1/70 (1%) 0/70 (0%) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 5.5% 2.5% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/45 (0%) 1/33 (3%) 1/40 (3%) 0/30 (0%) | 0/37 (0%) 0/40 (0%) 0/33 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | --- 677 722 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.537N P=0.185 P=0.477 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.501N P=0.274 P=0.477 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.515N P=0.207 P=0.477 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.461N | (e) |
|FISHER EXACT | P=0.248 P=0.500 (e) | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 1/70 (1%) | 4/70 (6%) 0/70 (0%) 0/70 (0%) 1/70 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 3.3% | 9.4% 0.0% 0.0% 4.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/45 (0%) 0/33 (0%) 0/40 (0%) 1/30 (3%) | 1/37 (3%) 0/40 (0%) 0/33 (0%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 722 (T) | 645 --- --- 722 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.161 (e) (e) P=0.419 | P=0.185N P=0.068N P=0.081N P=0.298N |
|INCIDENTAL TUMOR | P=0.161 (e) (e) P=0.419 | P=0.104N P=0.181N P=0.052N P=0.185N |
|LOGISTIC REGRESSION | P=0.160 (e) (e) P=0.419 | P=0.161N P=0.070N P=0.073N P=0.257N |
|COCHRAN-ARMITAGE | P=0.199 | P=0.126N |
|FISHER EXACT | (e) (e) P=0.500 | P=0.060N P=0.060N P=0.183N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 1/70 (1%) | 4/70 (6%) 0/70 (0%) 0/70 (0%) 1/70 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 3.3% | 9.4% 0.0% 0.0% 4.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/45 (0%) 0/33 (0%) 0/40 (0%) 1/30 (3%) | 1/37 (3%) 0/40 (0%) 0/33 (0%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 722 (T) | 645 --- --- 722 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.161 (e) (e) P=0.419 | P=0.185N P=0.068N P=0.081N P=0.298N |
|INCIDENTAL TUMOR | P=0.161 (e) (e) P=0.419 | P=0.104N P=0.181N P=0.052N P=0.185N |
|LOGISTIC REGRESSION | P=0.160 (e) (e) P=0.419 | P=0.161N P=0.070N P=0.073N P=0.257N |
|COCHRAN-ARMITAGE | P=0.199 | P=0.126N |
|FISHER EXACT | (e) (e) P=0.500 | P=0.060N P=0.060N P=0.183N |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 0/70 (0%) 2/69 (3%) 1/70 (1%) | 0/70 (0%) 2/70 (3%) 1/70 (1%) 1/70 (1%) |
|ADJUSTED (b) | 2.2% 0.0% 4.7% 2.6% | 0.0% 5.0% 3.0% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/45 (2%) 0/33 (0%) 1/40 (3%) 0/30 (0%) | 0/37 (0%) 2/40 (5%) 1/33 (3%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 722 (T) --- 615 651 | --- 722 (T) 722 (T) 714 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.421 P=0.562N P=0.458 P=0.688 | P=0.379 P=0.256 P=0.477 P=0.439 |
|INCIDENTAL TUMOR | P=0.562 P=0.562N P=0.735 P=0.759N | P=0.445 P=0.256 P=0.477 P=0.540 |
|LOGISTIC REGRESSION | P=0.457 P=0.562N P=0.476 P=0.722 | P=0.395 P=0.256 P=0.477 P=0.440 |
|COCHRAN-ARMITAGE | P=0.500 | P=0.500 |
|FISHER EXACT | P=0.500N P=0.495 P=0.752N | P=0.248 P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 1/70 (1%) 2/70 (3%) 2/70 (3%) | 0/70 (0%) 3/70 (4%) 2/70 (3%) 1/70 (1%) |
|ADJUSTED (b) | 4.4% 2.5% 5.0% 6.7% | 0.0% 7.2% 6.1% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/45 (4%) 0/33 (0%) 2/40 (5%) 2/30 (7%) | 0/37 (0%) 2/40 (5%) 2/33 (6%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 722 (T) 673 722 (T) 722 (T) | --- 600 722 (T) 714 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.401 P=0.592N P=0.652 P=0.541 | P=0.418 P=0.126 P=0.213 P=0.439 |
|INCIDENTAL TUMOR | P=0.426 P=0.494N P=0.652 P=0.541 | P=0.489 P=0.115 P=0.213 P=0.540 |
|LOGISTIC REGRESSION | P=0.430 P=0.555N P=0.652 P=0.541 | P=0.471 P=0.112 P=0.213 P=0.440 |
|COCHRAN-ARMITAGE | P=0.526 | P=0.555 |
|FISHER EXACT | P=0.500N P=0.690N P=0.690N | P=0.122 P=0.248 P=0.500 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 0/70 (0%) 2/70 (3%) 2/70 (3%) | 0/70 (0%) 3/70 (4%) 2/70 (3%) 1/70 (1%) |
|ADJUSTED (b) | 2.2% 0.0% 5.0% 6.7% | 0.0% 7.2% 6.1% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/45 (2%) 0/33 (0%) 2/40 (5%) 2/30 (7%) | 0/37 (0%) 2/40 (5%) 2/33 (6%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 722 (T) --- 722 (T) 722 (T) | --- 600 722 (T) 714 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.162 P=0.562N P=0.459 P=0.360 | P=0.418 P=0.126 P=0.213 P=0.439 |
|INCIDENTAL TUMOR | P=0.162 P=0.562N P=0.459 P=0.360 | P=0.489 P=0.115 P=0.213 P=0.540 |
|LOGISTIC REGRESSION | P=0.162 P=0.562N P=0.459 P=0.360 | P=0.471 P=0.112 P=0.213 P=0.440 |
|COCHRAN-ARMITAGE | P=0.246 | P=0.555 |
|FISHER EXACT | P=0.500N P=0.500 P=0.500 | P=0.122 P=0.248 P=0.500 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 2/70 (3%) 0/70 (0%) 0/70 (0%) | 1/69 (1%) 1/70 (1%) 0/70 (0%) 1/70 (1%) |
|ADJUSTED (b) | 2.2% 6.1% 0.0% 0.0% | 2.8% 2.5% 0.0% 4.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/45 (2%) 2/33 (6%) 0/40 (0%) 0/30 (0%) | 1/36 (3%) 1/40 (3%) 0/33 (0%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 722 (T) 722 (T) --- --- | 722 (T) 722 (T) --- 722 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.243N P=0.392 P=0.523N P=0.581N | P=0.602 P=0.738N P=0.517N P=0.678 |
|INCIDENTAL TUMOR | P=0.243N P=0.392 P=0.523N P=0.581N | P=0.602 P=0.738N P=0.517N P=0.678 |
|LOGISTIC REGRESSION | P=0.243N P=0.392 P=0.523N P=0.581N | P=0.602 P=0.738N P=0.517N P=0.678 |
|COCHRAN-ARMITAGE | P=0.189N | P=0.613N |
|FISHER EXACT | P=0.500 P=0.500N P=0.500N | P=0.748N P=0.496N P=0.748N |
|=================================================================================================================================|
| |
|Uterus |
| Leiomyosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/70 (0%) 2/70 (3%) 0/70 (0%) 1/70 (1%) |
|ADJUSTED (b) | | 0.0% 5.0% 0.0% 4.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | | 0/37 (0%) 2/40 (5%) 0/33 (0%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | | --- 722 (T) --- 722 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.429 P=0.256 (e) P=0.422 |
|INCIDENTAL TUMOR | | P=0.429 P=0.256 (e) P=0.422 |
|LOGISTIC REGRESSION | | P=0.429 P=0.256 (e) P=0.422 |
|COCHRAN-ARMITAGE | | P=0.539 |
|FISHER EXACT | | P=0.248 (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 1/70 (1%) 2/70 (3%) 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | | 2.4% 4.4% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | | 0/37 (0%) 0/40 (0%) 0/33 (0%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | | 706 510 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.232N P=0.487 P=0.520N P=0.569N |
|INCIDENTAL TUMOR | | P=0.047N* P=0.500 P=0.479N P=0.460N |
|LOGISTIC REGRESSION | | P=0.155N P=0.447 P=0.517N P=0.553N |
|COCHRAN-ARMITAGE | | P=0.189N |
|FISHER EXACT | | P=0.500 P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 0/70 (0%) 0/70 (0%) 1/70 (1%) | 1/70 (1%) 1/70 (1%) 0/70 (0%) 1/70 (1%) |
|ADJUSTED (b) | 4.4% 0.0% 0.0% 3.3% | 2.7% 2.5% 0.0% 4.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 2/45 (4%) 0/33 (0%) 0/40 (0%) 1/30 (3%) | 1/37 (3%) 1/40 (3%) 0/33 (0%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 722 (T) --- --- 722 (T) | 722 (T) 722 (T) --- 722 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.545N P=0.309N P=0.265N P=0.640N | P=0.596 P=0.744N P=0.523N P=0.672 |
|INCIDENTAL TUMOR | P=0.545N P=0.309N P=0.265N P=0.640N | P=0.596 P=0.744N P=0.523N P=0.672 |
|LOGISTIC REGRESSION | P=0.545N P=0.309N P=0.265N P=0.640N | P=0.596 P=0.744N P=0.523N P=0.672 |
|COCHRAN-ARMITAGE | P=0.461N | P=0.616N |
|FISHER EXACT | P=0.248N P=0.248N P=0.500N | P=0.752N P=0.500N P=0.752N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 2/70 (3%) 4/70 (6%) 3/70 (4%) | 1/70 (1%) 4/70 (6%) 1/70 (1%) 1/70 (1%) |
|ADJUSTED (b) | 8.9% 5.5% 9.6% 8.5% | 2.7% 9.5% 3.0% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 4/45 (9%) 1/33 (3%) 3/40 (8%) 1/30 (3%) | 1/37 (3%) 3/40 (8%) 1/33 (3%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 722 (T) 677 615 651 | 722 (T) 510 722 (T) 714 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.476 P=0.479N P=0.576 P=0.614 | P=0.515N P=0.197 P=0.736 P=0.681 |
|INCIDENTAL TUMOR | P=0.567N P=0.405N P=0.564N P=0.585N | P=0.311N P=0.333 P=0.736 P=0.742 |
|LOGISTIC REGRESSION | P=0.530 P=0.427N P=0.590 P=0.630N | P=0.449N P=0.166 P=0.736 P=0.689 |
|COCHRAN-ARMITAGE | P=0.519N | P=0.373N |
|FISHER EXACT | P=0.340N P=0.641N P=0.500N | P=0.183 P=0.752N P=0.752N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/70 (9%) 2/70 (3%) 4/70 (6%) 4/70 (6%) | 2/70 (3%) 5/70 (7%) 1/70 (1%) 2/70 (3%) |
|ADJUSTED (b) | 13.3% 5.5% 9.6% 11.6% | 5.4% 11.9% 3.0% 7.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 6/45 (13%) 1/33 (3%) 3/40 (8%) 2/30 (7%) | 2/37 (5%) 4/40 (10%) 1/33 (3%) 1/25 (4%) |
|FIRST INCIDENCE (DAYS) | 722 (T) 677 615 651 | 722 (T) 510 722 (T) 714 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.529 P=0.250N P=0.446N P=0.613N | P=0.552N P=0.242 P=0.540N P=0.555 |
|INCIDENTAL TUMOR | P=0.509N P=0.200N P=0.303N P=0.519N | P=0.375N P=0.373 P=0.540N P=0.605 |
|LOGISTIC REGRESSION | P=0.556N P=0.206N P=0.434N P=0.539N | P=0.476N P=0.197 P=0.540N P=0.567 |
|COCHRAN-ARMITAGE | P=0.431N | P=0.372N |
|FISHER EXACT | P=0.137N P=0.372N P=0.372N | P=0.221 P=0.500N P=0.690N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 0/70 (0%) 0/70 (0%) 1/70 (1%) | 9/70 (13%) 9/70 (13%) 10/70 (14%) 3/70 (4%) |
|ADJUSTED (b) | 4.3% 0.0% 0.0% 3.3% | 20.9% 20.8% 26.2% 8.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/45 (2%) 0/33 (0%) 0/40 (0%) 1/30 (3%) | 5/37 (14%) 6/40 (15%) 7/33 (21%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 699 --- --- 722 (T) | 640 588 449 437 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.540N P=0.308N P=0.265N P=0.633N | P=0.198N P=0.574N P=0.406 P=0.176N |
|INCIDENTAL TUMOR | P=0.501N P=0.194N P=0.310N P=0.540N | P=0.036N* P=0.356 P=0.485 P=0.036N* |
|LOGISTIC REGRESSION | P=0.522N P=0.275N P=0.260N P=0.598N | P=0.071N P=0.332 P=0.406 P=0.071N |
|COCHRAN-ARMITAGE | P=0.461N | P=0.057N |
|FISHER EXACT | P=0.248N P=0.248N P=0.500N | P=0.599N P=0.500 P=0.064N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 0/70 (0%) 0/70 (0%) 1/70 (1%) | 9/70 (13%) 9/70 (13%) 10/70 (14%) 3/70 (4%) |
|ADJUSTED (b) | 4.3% 0.0% 0.0% 3.3% | 20.9% 20.8% 26.2% 8.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 1/45 (2%) 0/33 (0%) 0/40 (0%) 1/30 (3%) | 5/37 (14%) 6/40 (15%) 7/33 (21%) 0/25 (0%) |
|FIRST INCIDENCE (DAYS) | 699 --- --- 722 (T) | 640 588 449 437 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.540N P=0.308N P=0.265N P=0.633N | P=0.198N P=0.574N P=0.406 P=0.176N |
|INCIDENTAL TUMOR | P=0.501N P=0.194N P=0.310N P=0.540N | P=0.036N* P=0.356 P=0.485 P=0.036N* |
|LOGISTIC REGRESSION | P=0.522N P=0.275N P=0.260N P=0.598N | P=0.071N P=0.332 P=0.406 P=0.071N |
|COCHRAN-ARMITAGE | P=0.461N | P=0.057N |
|FISHER EXACT | P=0.248N P=0.248N P=0.500N | P=0.599N P=0.500 P=0.064N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 31/70 (44%) 27/70 (39%) 28/70 (40%) 28/70 (40%) | 29/70 (41%) 25/70 (36%) 22/70 (31%) 23/70 (33%) |
|ADJUSTED (b) | 63.0% 66.3% 59.0% 68.5% | 64.0% 56.6% 59.0% 65.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 3/10 (30%) 1/10 (10%) 4/10 (40%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 27/45 (60%) 20/33 (61%) 21/40 (53%) 18/30 (60%) | 21/37 (57%) 21/40 (53%) 18/33 (55%) 14/25 (56%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 433 387 | 456 (I) 510 668 437 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.151 P=0.298 P=0.554 P=0.131 | P=0.261 P=0.218N P=0.276N P=0.366 |
|INCIDENTAL TUMOR | P=0.486 P=0.545N P=0.350N P=0.512 | P=0.394N P=0.339N P=0.237N P=0.418N |
|LOGISTIC REGRESSION | P=0.383 P=0.525N P=0.499N P=0.427 | P=0.492N P=0.387N P=0.219N P=0.500N |
|COCHRAN-ARMITAGE | P=0.387N | P=0.171N |
|FISHER EXACT | P=0.303N P=0.366N P=0.366N | P=0.301N P=0.146N P=0.191N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 17/70 (24%) 16/70 (23%) 17/70 (24%) 11/70 (16%) | 18/70 (26%) 16/70 (23%) 15/70 (21%) 11/70 (16%) |
|ADJUSTED (b) | 34.7% 38.0% 35.7% 28.6% | 40.4% 36.2% 37.3% 32.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|TERMINAL (d) | 13/45 (29%) 7/33 (21%) 10/40 (25%) 5/30 (17%) | 11/37 (30%) 12/40 (30%) 9/33 (27%) 4/25 (16%) |
|FIRST INCIDENCE (DAYS) | 650 650 370 456 (I) | 640 510 449 437 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.412N P=0.309 P=0.432 P=0.494N | P=0.410N P=0.375N P=0.479N P=0.412N |
|INCIDENTAL TUMOR | P=0.067N P=0.378N P=0.395N P=0.116N | P=0.051N P=0.554 P=0.353N P=0.110N |
|LOGISTIC REGRESSION | P=0.144N P=0.253N P=0.494 P=0.162N | P=0.150N P=0.585 P=0.461N P=0.257N |
|COCHRAN-ARMITAGE | P=0.125N | P=0.084N |
|FISHER EXACT | P=0.500N P=0.578N P=0.145N | P=0.422N P=0.345N P=0.105N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG | 0 MG/KG 120MG/KG 240MG/KG 480MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 39/70 (56%) 36/70 (51%) 38/70 (54%) 32/70 (46%) | 40/70 (57%) 35/70 (50%) 29/70 (41%) 30/70 (43%) |
|ADJUSTED (b) | 76.4% 76.3% 74.3% 71.7% | 81.5% 74.5% 72.0% 76.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 3/10 (30%) 1/10 (10%) 4/10 (40%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/9 (11%) |
|TERMINAL (d) | 33/45 (73%) 22/33 (67%) 27/40 (68%) 18/30 (60%) | 28/37 (76%) 28/40 (70%) 22/33 (67%) 16/25 (64%) |
|FIRST INCIDENCE (DAYS) | 455 (I) 455 (I) 370 387 | 456 (I) 510 449 437 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.282 P=0.149 P=0.351 P=0.234 | P=0.353 P=0.165N P=0.137N P=0.437 |
|INCIDENTAL TUMOR | P=0.176N P=0.482N P=0.370N P=0.255N | P=0.097N P=0.423N P=0.052N P=0.176N |
|LOGISTIC REGRESSION | P=0.421N P=0.482 P=0.469 P=0.484N | P=0.180N P=0.424N P=0.064N P=0.322N |
|COCHRAN-ARMITAGE | P=0.151N | P=0.049N* |
|FISHER EXACT | P=0.367N P=0.500N P=0.155N | P=0.249N P=0.045N* P=0.064N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 93 455
Female interim sacrifices(days): 93 455
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).