INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
O-BENZYL-P-CHLOROPHENOL
NTP Experiment-Test: 05086-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/11/94
Route: GAVAGE Time: 06:48:22
Facility: Battelle Columbus Laboratory
Chemical CAS #: 120-32-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0MG/KG 0MG/KG 0MG/KG 60MG/KG 60MG/KG 60MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10 10 60 10 10
Scheduled Sacrifice 10 10 10 10 10 9
Early Deaths
Moribund Sacrifice 17 12
Dosing Accident 2 1
Natural Death 5 7 1
Survivors
Terminal Sacrifice 26 30
Animals Examined Microscopically 60 10 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (10) (50)
Muscularis, Inflammation, Chronic 1 (10%)
Intestine Large, Colon (59) (10) (50)
Parasite Metazoan 3 (5%)
Intestine Large, Rectum (59) (10) (50)
Parasite Metazoan 3 (5%) 1 (10%) 6 (12%)
Intestine Small, Duodenum (60) (10) (50)
Inflammation, Necrotizing 2 (3%)
Liver (60) (10) (54)
Basophilic Focus 41 (68%) 43 (80%)
Clear Cell Focus 6 (10%) 10 (19%)
Eosinophilic Focus 1 (2%) 2 (4%)
Fatty Change 1 (2%) 4 (7%)
Hepatodiaphragmatic Nodule 8 (13%) 9 (17%)
Inflammation, Granulomatous 8 (13%) 9 (17%)
Mixed Cell Focus 3 (6%)
Bile Duct, Hyperplasia 35 (58%) 37 (69%)
Centrilobular, Necrosis 3 (6%)
Mesentery (4) (3)
Fat, Necrosis 4 (100%) 2 (67%)
Pancreas (60) (10) (50)
Inflammation, Chronic 1 (10%)
Acinus, Atrophy 11 (18%) 12 (24%)
Acinus, Hyperplasia 4 (7%) 1 (2%)
Pharynx (1)
Inflammation, Suppurative 1 (100%)
Salivary Glands (60) (10) (50)
Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (60) (10) (50)
Inflammation, Chronic 1 (2%)
Inflammation, Necrotizing 2 (3%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0MG/KG 0MG/KG 0MG/KG 60MG/KG 60MG/KG 60MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Epithelium, Hyperplasia 1 (2%) 2 (4%)
Stomach, Glandular (59) (10) (50)
Inflammation, Necrotizing 1 (2%) 3 (6%)
Mineralization 3 (5%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (10) (50)
Thrombosis 1 (2%)
Myocardium, Degeneration, Chronic 40 (67%) 3 (30%) 43 (86%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (10) (50)
Hyperplasia 15 (25%) 14 (28%)
Hypertrophy 1 (2%) 2 (4%)
Necrosis 1 (2%) 2 (4%)
Adrenal Gland, Medulla (60) (10) (50)
Hyperplasia 8 (13%) 4 (8%)
Islets, Pancreatic (60) (10) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (56) (10) (44)
Hyperplasia 1 (2%)
Pituitary Gland (60) (10) (51)
Pars Distalis, Ectasia 1 (2%)
Pars Distalis, Hyperplasia 27 (45%) 22 (43%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (60) (10) (50)
C-Cell, Hyperplasia 19 (32%) 8 (16%)
Follicular Cell, Hyperplasia 5 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59) (10) (48)
Hyperplasia 1 (2%) 2 (4%)
Inflammation, Chronic Active 2 (3%) 2 (4%)
Duct, Dilatation 1 (2%)
Ovary (60) (10) (52) (1)
Cyst 2 (3%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0MG/KG 0MG/KG 0MG/KG 60MG/KG 60MG/KG 60MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Periovarian Tissue, Cyst 1 (2%) 1 (2%)
Vagina (1)
Inflammation, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (10) (50)
Femoral, Hyperplasia, Reticulum Cell 1 (10%)
Lymph Node, Mesenteric (59) (10) (48)
Edema 1 (2%)
Spleen (60) (10) (50)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Thymus (58) (10) (46)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (9) (50)
Hyperplasia 1 (2%)
Skin (60) (10) (50)
Inflammation, Chronic Active 2 (3%) 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (10) (50)
Compression 5 (8%) 2 (4%)
Developmental Malformation 1 (2%)
Infarct 1 (2%)
Inflammation, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0MG/KG 0MG/KG 0MG/KG 60MG/KG 60MG/KG 60MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10) (50)
Foreign Body 1 (2%) 2 (4%)
Inflammation, Chronic Active 8 (13%) 2 (20%) 1 (2%)
Inflammation, Necrotizing 2 (3%) 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (7%) 8 (16%)
Nose (60) (10) (50)
Mucosa, Inflammation, Suppurative 2 (3%) 3 (6%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (4)
Degeneration 1 (25%)
Lens, Cataract 1 (100%) 2 (50%)
Retina, Atrophy 1 (100%) 1 (25%)
Harderian Gland (1) (1)
Inflammation, Chronic Active 1 (100%)
Zymbal's Gland (1)
Cyst 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10) (60) (10)
Infarct 1 (2%)
Nephropathy 55 (92%) 1 (10%) 57 (95%) 3 (30%)
Corticomedullary Junction, Concretion 1 (10%)
Corticomedullary Junction, Mineralization 5 (50%) 6 (60%)
Pelvis, Inflammation, Suppurative 1 (2%)
Pelvis, Mineralization 3 (5%) 2 (3%)
Urinary Bladder (60) (10) (50)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 120MG/KG 120MG/KG 120MG/KG 240MG/KG 240MG/KG 240MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10 10 60 10 10
Scheduled Sacrifice 9 8 9 10 9 8
Early Deaths
Moribund Sacrifice 15 18
Natural Death 7 1 3 1
Dosing Accident 1 2 1 2
Survivors
Terminal Sacrifice 28 28
Animals Examined Microscopically 60 8 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (52) (60) (10)
Foreign Body 1 (2%)
Inflammation, Chronic Active 2 (4%)
Inflammation, Necrotizing 1 (2%)
Muscularis, Inflammation, Chronic 1 (10%)
Intestine Large, Cecum (51) (60) (10)
Inflammation, Necrotizing 1 (2%)
Intestine Large, Rectum (51) (60) (9)
Parasite Metazoan 3 (6%) 1 (2%)
Intestine Small, Duodenum (51) (60) (10)
Inflammation, Necrotizing 1 (2%)
Liver (52) (60) (10)
Basophilic Focus 41 (79%) 43 (72%)
Clear Cell Focus 9 (17%) 16 (27%)
Degeneration, Cystic 1 (2%) 2 (3%)
Eosinophilic Focus 3 (6%) 2 (3%)
Fatty Change 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 9 (17%) 8 (13%)
Inflammation, Granulomatous 5 (10%) 2 (3%)
Inflammation, Necrotizing 1 (2%) 2 (3%)
Bile Duct, Hyperplasia 33 (63%) 25 (42%)
Mesentery (1) (5)
Fibrosis 1 (100%)
Hemorrhage 1 (20%)
Fat, Necrosis 3 (60%)
Pancreas (50) (60) (10)
Acinus, Atrophy 8 (16%) 16 (27%)
Acinus, Hyperplasia 1 (2%)
Salivary Glands (50) (60) (10)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 120MG/KG 120MG/KG 120MG/KG 240MG/KG 240MG/KG 240MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (52) (60) (10)
Cyst 1 (2%)
Inflammation, Chronic 2 (3%)
Inflammation, Necrotizing 1 (2%) 5 (8%)
Stomach, Glandular (51) (60) (10)
Inflammation, Necrotizing 3 (5%)
Mineralization 2 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (51) (60) (10)
Mineralization 1 (2%)
Myocardium, Degeneration, Chronic 42 (82%) 44 (73%) 2 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (51) (60) (10)
Hyperplasia 10 (20%) 26 (43%)
Hypertrophy 4 (8%) 2 (3%)
Necrosis 1 (2%)
Adrenal Gland, Medulla (51) (60) (10)
Hyperplasia 3 (6%) 10 (17%)
Parathyroid Gland (46) (57) (8)
Hyperplasia 1 (2%)
Pituitary Gland (51) (60) (10)
Pars Distalis, Ectasia 1 (2%)
Pars Distalis, Hyperplasia 30 (59%) 28 (47%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (51) (60) (10)
C-Cell, Hyperplasia 11 (22%) 22 (37%)
Follicular Cell, Hyperplasia 1 (2%) 4 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (56) (10)
Hyperplasia 5 (10%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Duct, Dilatation 2 (4%)
Ovary (51) (60) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 120MG/KG 120MG/KG 120MG/KG 240MG/KG 240MG/KG 240MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cyst 3 (6%) 1 (2%)
Uterus (53) (60) (10)
Dilatation 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (51) (60) (10)
Femoral, Hyperplasia, Reticulum Cell 1 (10%)
Lymph Node (51) (60) (10)
Mediastinal, Edema 1 (2%)
Spleen (51) (60) (10)
Hematopoietic Cell Proliferation 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (60) (10)
Hyperplasia 2 (4%)
Skin (50) (60) (10)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (51) (60) (10)
Compression 1 (2%) 6 (10%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (51) (59) (10)
Inflammation, Chronic Active 1 (2%) 4 (7%) 2 (20%)
Inflammation, Necrotizing 1 (2%)
Mineralization 2 (3%)
Alveolar Epithelium, Hyperplasia 2 (4%) 7 (12%)
Nose (51) (60) (10)
Mucosa, Inflammation, Suppurative 6 (12%) 4 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 120MG/KG 120MG/KG 120MG/KG 240MG/KG 240MG/KG 240MG/KG
F 13HUCC F 65HUCC F F 13HUCC F 65HUCC F
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (7) (1) (6) (1)
Degeneration 2 (29%) 3 (50%)
Inflammation, Chronic Active 2 (33%)
Lens, Cataract 3 (43%) 1 (100%) 1 (17%) 1 (100%)
Retina, Atrophy 3 (43%) 1 (100%)
Harderian Gland (1) (1)
Inflammation, Chronic Active 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (8) (60) (10)
Atrophy 1 (2%)
Calculus Micro Observation Only 2 (3%)
Mineralization 1 (2%)
Nephropathy 59 (98%) 3 (38%) 60 (100%) 7 (70%)
Corticomedullary Junction, Mineralization 3 (38%) 1 (10%)
Pelvis, Inflammation, Suppurative 1 (2%) 2 (3%)
Pelvis, Mineralization 2 (3%) 16 (27%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (51) (60) (10)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0MG/KG 0MG/KG 0MG/KG 30MG/KG 30MG/KG 30MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10 10 60 10 10
Scheduled Sacrifice 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 16 13
Natural Death 5 11
Dosing Accident 6 2
Survivors
Terminal Sacrifice 23 24
Animals Examined Microscopically 60 10 60 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (10) (50)
Foreign Body 2 (3%)
Inflammation, Chronic Active 3 (5%)
Muscularis, Inflammation, Chronic 2 (20%)
Intestine Large, Cecum (58) (10) (48)
Inflammation, Necrotizing 1 (2%)
Intestine Large, Colon (60) (10) (50)
Inflammation, Necrotizing 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Large, Rectum (60) (10) (49)
Parasite Metazoan 2 (3%) 1 (10%) 7 (14%)
Intestine Small, Jejunum (59) (10) (48)
Inflammation, Necrotizing 1 (2%)
Liver (60) (10) (51)
Basophilic Focus 35 (58%) 33 (65%)
Clear Cell Focus 23 (38%) 16 (31%)
Degeneration, Cystic 6 (10%) 3 (6%)
Eosinophilic Focus 7 (12%) 6 (12%)
Fatty Change 7 (12%) 1 (2%)
Hepatodiaphragmatic Nodule 2 (3%) 4 (8%)
Inflammation, Granulomatous 3 (5%)
Inflammation, Necrotizing 2 (3%)
Mixed Cell Focus 1 (2%) 3 (6%)
Bile Duct, Hyperplasia 46 (77%) 43 (84%)
Centrilobular, Necrosis 1 (2%) 9 (18%)
Mesentery (14) (14)
Hemorrhage 1 (7%)
Fat, Necrosis 13 (93%) 8 (57%)
Pancreas (59) (10) (47)
Basophilic Focus 1 (2%)
Acinus, Atrophy 20 (34%) 10 (21%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0MG/KG 0MG/KG 0MG/KG 30MG/KG 30MG/KG 30MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Hyperplasia 6 (10%) 11 (23%)
Stomach, Forestomach (59) (10) (50)
Inflammation, Chronic 1 (2%)
Inflammation, Necrotizing 4 (7%) 5 (10%)
Epithelium, Hyperplasia 3 (6%)
Stomach, Glandular (59) (10) (49)
Inflammation, Necrotizing 2 (3%) 7 (14%)
Mineralization 2 (3%) 4 (8%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Foreign Body 1 (50%)
Inflammation, Chronic Active 1 (50%)
Heart (60) (10) (50)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Myocardium, Degeneration, Chronic 55 (92%) 9 (90%) 46 (92%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (10) (50)
Hemorrhage, Chronic 1 (2%)
Hyperplasia 20 (33%) 12 (24%)
Hypertrophy 4 (7%) 1 (2%)
Necrosis 1 (2%)
Adrenal Gland, Medulla (60) (10) (50)
Hemorrhage, Chronic 1 (2%)
Hyperplasia 18 (30%) 26 (52%)
Islets, Pancreatic (59) (10) (47)
Hyperplasia 4 (9%)
Parathyroid Gland (56) (9) (47)
Hyperplasia 2 (4%)
Pituitary Gland (58) (10) (51)
Pars Distalis, Ectasia 1 (2%)
Pars Distalis, Hyperplasia 20 (34%) 13 (25%)
Thyroid Gland (58) (10) (50)
C-Cell, Hyperplasia 16 (28%) 8 (16%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 2 (3%) 3 (6%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0MG/KG 0MG/KG 0MG/KG 30MG/KG 30MG/KG 30MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (59) (10) (50)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 2 (3%)
Duct, Dilatation 1 (2%)
Prostate (60) (10) (50)
Degeneration, Mucoid 1 (2%)
Dilatation 1 (2%)
Hyperplasia 2 (4%)
Inflammation, Chronic Active 5 (8%) 11 (22%)
Seminal Vesicle (60) (10) (50)
Dilatation 1 (2%)
Testes (60) (10) (49)
Degeneration 1 (2%)
Inflammation, Chronic Active 1 (2%)
Interstitial Cell, Hyperplasia 16 (27%) 6 (12%)
Seminiferous Tubule, Atrophy 3 (5%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (59) (10) (50)
Sinus, Ectasia 1 (2%)
Spleen (60) (10) (49)
Fibrosis 4 (7%) 2 (4%)
Inflammation, Necrotizing 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (59) (10) (51)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0MG/KG 0MG/KG 0MG/KG 30MG/KG 30MG/KG 30MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (3) (3)
Edema 1 (33%)
Diaphragm, Hemorrhage, Chronic 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (10) (50)
Compression 6 (10%) 3 (6%)
Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (10) (50)
Fibrosis 1 (2%)
Foreign Body 3 (5%) 2 (4%)
Inflammation, Chronic Active 9 (15%) 2 (20%) 2 (4%)
Inflammation, Necrotizing 5 (8%) 2 (4%)
Alveolar Epithelium, Hyperplasia 11 (18%) 10 (20%)
Mediastinum, Hemorrhage 1 (2%)
Nose (60) (10) (50)
Fungus 2 (3%)
Mucosa, Inflammation, Suppurative 14 (23%) 1 (10%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3)
Lens, Cataract 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10) (59) (10)
Mineralization 1 (2%) 2 (3%)
Nephropathy 58 (97%) 10 (100%) 58 (98%) 8 (80%)
Renal Tubule, Hyperplasia 2 (3%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (60) (10) (50)
Hemorrhage 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0MG/KG 0MG/KG 0MG/KG 30MG/KG 30MG/KG 30MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 60MG/KG 60MG/KG 60MG/KG 120MG/KG 120MG/KG 120MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 10 10 60 10 10
Scheduled Sacrifice 10 10 10 9 9 7
Early Deaths
Natural Death 6 8 2
Moribund Sacrifice 14 14
Dosing Accident 5 5 1 1
Survivors
Terminal Sacrifice 25 24
Animals Examined Microscopically 60 10 60 9
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (60) (9)
Dilatation 1 (2%)
Foreign Body 1 (2%)
Inflammation, Chronic Active 1 (2%)
Muscularis, Inflammation, Chronic 1 (11%)
Intestine Large, Rectum (49) (58) (9)
Parasite Metazoan 4 (8%) 2 (3%)
Intestine Small, Duodenum (49) (59) (9)
Inflammation, Necrotizing 1 (2%) 1 (2%)
Liver (51) (60) (9)
Basophilic Focus 25 (49%) 31 (52%)
Clear Cell Focus 21 (41%) 22 (37%)
Degeneration, Cystic 6 (12%)
Eosinophilic Focus 3 (6%) 7 (12%)
Fatty Change 3 (6%) 1 (2%)
Hepatodiaphragmatic Nodule 3 (6%) 4 (7%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Inflammation, Necrotizing 2 (4%)
Mixed Cell Focus 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 42 (82%) 35 (58%)
Mesentery (7) (8) (1)
Hemorrhage 1 (13%)
Inflammation, Granulomatous 1 (100%)
Fat, Necrosis 7 (100%) 7 (88%)
Pancreas (48) (58) (9)
Basophilic Focus 3 (5%)
Acinus, Atrophy 12 (25%) 19 (33%)
Acinus, Hyperplasia 8 (17%) 13 (22%)
Salivary Glands (49) (58) (9)
Inflammation, Chronic Active 2 (3%)
Stomach, Forestomach (49) (60) (9)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 60MG/KG 60MG/KG 60MG/KG 120MG/KG 120MG/KG 120MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 3 (5%)
Inflammation, Necrotizing 5 (10%) 4 (7%)
Mineralization 1 (2%)
Epithelium, Hyperplasia 4 (8%) 1 (2%)
Stomach, Glandular (49) (59) (9)
Inflammation, Necrotizing 4 (8%) 6 (10%)
Mineralization 2 (4%) 9 (15%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (60) (9)
Inflammation, Necrotizing 1 (2%) 1 (2%)
Mineralization 2 (3%)
Myocardium, Degeneration, Chronic 46 (92%) 54 (90%) 5 (56%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (60) (9)
Accessory Adrenal Cortical Nodule 1 (2%)
Hyperplasia 21 (42%) 19 (32%)
Hypertrophy 3 (6%)
Adrenal Gland, Medulla (49) (59) (9)
Hyperplasia 17 (35%) 20 (34%)
Islets, Pancreatic (48) (59) (9)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (45) (53) (8)
Hyperplasia 5 (11%) 8 (15%)
Pituitary Gland (49) (60) (9)
Pars Distalis, Ectasia 1 (2%)
Pars Distalis, Hyperplasia 15 (31%) 13 (22%)
Pars Nervosa, Hyperplasia, Glandular 1 (2%)
Thyroid Gland (47) (59) (9)
C-Cell, Hyperplasia 7 (15%) 11 (19%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 2 (4%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 60MG/KG 60MG/KG 60MG/KG 120MG/KG 120MG/KG 120MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (49) (60) (9)
Inflammation, Chronic Active 2 (3%) 1 (11%)
Duct, Dilatation 1 (2%)
Prostate (50) (60) (9)
Inflammation, Chronic Active 7 (14%) 7 (12%)
Seminal Vesicle (50) (60) (9)
Mineralization 1 (2%)
Testes (51) (60) (9)
Inflammation, Chronic Active 1 (2%) 3 (5%)
Mineralization 1 (2%)
Interstitial Cell, Hyperplasia 13 (25%) 20 (33%)
Seminiferous Tubule, Atrophy 3 (6%) 3 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (48) (58) (9)
Edema 2 (4%)
Mineralization 1 (2%)
Spleen (50) (59) (9)
Fibrosis 3 (6%) 7 (12%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (44) (48) (6)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 2 (4%)
Skin (50) (60) (9)
Edema 1 (2%)
Inflammation, Chronic Active 3 (6%) 4 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (60) (9)
Cranium, Fibrous Osteodystrophy 2 (4%) 4 (7%)
Femur, Fibrous Osteodystrophy 2 (4%) 6 (10%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (60) (9)
Compression 5 (10%) 1 (2%)
Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05086-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC O-BENZYL-P-CHLOROPHENOL Date: 09/11/94
Route: GAVAGE Time: 06:48:22
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 60MG/KG 60MG/KG 60MG/KG 120MG/KG 120MG/KG 120MG/KG
M 13HUCC M 65HUCC M M 13HUCC M 65HUCC M
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (60) (9)
Foreign Body 4 (8%) 3 (5%)
Inflammation, Chronic Active 6 (12%) 4 (7%) 2 (22%)
Inflammation, Necrotizing 4 (8%) 5 (8%)
Mineralization 2 (3%)
Alveolar Epithelium, Hyperplasia 12 (24%) 10 (17%)
Mediastinum, Hemorrhage 1 (2%)
Nose (48) (60) (9)
Foreign Body 1 (2%)
Mucosa, Inflammation, Suppurative 7 (15%) 6 (10%)
Trachea (50) (59) (9)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2)
Pinna, Inflammation, Chronic Active 1 (50%)
Eye (1) (7)
Degeneration 1 (100%) 2 (29%)
Inflammation, Chronic Active 3 (43%)
Cornea, Mineralization 1 (14%)
Lens, Cataract 1 (14%)
Retina, Atrophy 1 (14%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (10) (59) (9)
Mineralization 3 (5%)
Nephropathy 58 (97%) 9 (90%) 59 (100%) 8 (89%)
Pelvis, Inflammation, Suppurative 1 (2%)
Renal Tubule, Hyperplasia 2 (3%)
Transitional Epithelium, Hyperplasia 2 (3%) 1 (2%)
Urinary Bladder (50) (59) (9)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
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