TDMS Study 05086-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus O-BENZYL-P-CHLOROPHENOL DATE: 09/11/94
EXPERIMENT: 05086 TEST: 01 TIME: 07:04:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45042 ROUTE: GAVAGE NTP C#: 61201C
PATHOLOGIST: S. GRUMBEIN CAS: 120-32-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus O-BENZYL-P-CHLOROPHENOL DATE: 09/11/94
EXPERIMENT: 05086 TEST: 01 TIME: 07:04:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45042 ROUTE: GAVAGE NTP C#: 61201C
PATHOLOGIST: S. GRUMBEIN CAS: 120-32-1
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus O-BENZYL-P-CHLOROPHENOL DATE: 09/11/94
EXPERIMENT: 05086 TEST: 01 TIME: 07:04:54
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45042 ROUTE: GAVAGE NTP C#: 61201C
PATHOLOGIST: S. GRUMBEIN CAS: 120-32-1
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF O-BENZYL-P-CHLOROPHENOL
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Carcinoma or Adenoma
Skin Keratoacanthoma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Squamous Cell Papilloma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Mesothelioma Benign, Malignant, NOS
Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Carcinoma or Adenoma
Mammary Gland Fibroadenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Carcinoma or Adenoma
Uterus Polyp Stromal
====================================================================================================
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/70 (19%) 7/70 (10%) 9/69 (13%) 13/68 (19%) | 0/70 (0%) 3/70 (4%) 3/68 (4%) 4/70 (6%) |
|ADJUSTED (b) | 44.1% 26.1% 32.2% 45.6% | 0.0% 8.3% 10.7% 12.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/23 (30%) 5/24 (21%) 7/25 (28%) 9/24 (38%) | 0/26 (0%) 1/30 (3%) 3/28 (11%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 638 669 579 641 | --- 649 729 (T) 661 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.404 P=0.104N P=0.203N P=0.562N | P=0.086 P=0.143 P=0.133 P=0.074 |
|INCIDENTAL TUMOR | P=0.320 P=0.110N P=0.208N P=0.501 | P=0.101 P=0.140 P=0.133 P=0.087 |
|LOGISTIC REGRESSION | P=0.342 P=0.100N P=0.245N P=0.555 | P=0.086 P=0.133 P=0.133 P=0.073 |
|COCHRAN-ARMITAGE | P=0.357 | P=0.079 |
|FISHER EXACT | P=0.113N P=0.255N P=0.554 | P=0.122 P=0.117 P=0.060 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 1/70 (1%) 1/69 (1%) 2/68 (3%) | 0/70 (0%) 1/70 (1%) 0/68 (0%) 0/70 (0%) |
|ADJUSTED (b) | 4.3% 4.2% 4.0% 6.8% | 0.0% 2.4% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/23 (4%) 1/24 (4%) 1/25 (4%) 1/24 (4%) | 0/26 (0%) 0/30 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) 591 | --- 633 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.353 P=0.753N P=0.744N P=0.498 | P=0.555N P=0.531 (e) (e) |
|INCIDENTAL TUMOR | P=0.338 P=0.753N P=0.744N P=0.477 | P=0.564N P=0.500 (e) (e) |
|LOGISTIC REGRESSION | P=0.336 P=0.753N P=0.744N P=0.484 | P=0.563N P=0.507 (e) (e) |
|COCHRAN-ARMITAGE | P=0.341 | P=0.567N |
|FISHER EXACT | P=0.752N P=0.748 P=0.489 | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/70 (20%) 7/70 (10%) 10/69 (14%) 15/68 (22%) | 0/70 (0%) 4/70 (6%) 3/68 (4%) 4/70 (6%) |
|ADJUSTED (b) | 47.6% 26.1% 35.9% 50.6% | 0.0% 10.5% 10.7% 12.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/23 (35%) 5/24 (21%) 8/25 (32%) 10/24 (42%) | 0/26 (0%) 1/30 (3%) 3/28 (11%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 638 669 579 591 | --- 633 729 (T) 661 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.283 P=0.069N P=0.202N P=0.523 | P=0.128 P=0.083 P=0.133 P=0.074 |
|INCIDENTAL TUMOR | P=0.204 P=0.072N P=0.207N P=0.400 | P=0.145 P=0.075 P=0.133 P=0.087 |
|LOGISTIC REGRESSION | P=0.219 P=0.064N P=0.252N P=0.444 | P=0.127 P=0.071 P=0.133 P=0.073 |
|COCHRAN-ARMITAGE | P=0.246 | P=0.116 |
|FISHER EXACT | P=0.077N P=0.263N P=0.465 | P=0.060 P=0.117 P=0.060 |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/69 (10%) 4/68 (6%) 2/69 (3%) 2/69 (3%) | 8/69 (12%) 7/68 (10%) 4/66 (6%) 4/67 (6%) |
|ADJUSTED (b) | 21.2% 13.3% 8.0% 8.3% | 28.1% 21.1% 12.8% 13.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 1/10 (10%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/23 (13%) 2/24 (8%) 2/25 (8%) 2/24 (8%) | 6/25 (24%) 5/29 (17%) 3/28 (11%) 3/27 (11%) |
|FIRST INCIDENCE (DAYS) | 457 456 (I) 729 (T) 729 (T) | 583 632 582 676 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.048N* P=0.265N P=0.082N P=0.089N | P=0.093N P=0.387N P=0.144N P=0.146N |
|INCIDENTAL TUMOR | P=0.050N P=0.267N P=0.085N P=0.092N | P=0.094N P=0.409N P=0.135N P=0.144N |
|LOGISTIC REGRESSION | P=0.050N* P=0.273N P=0.082N P=0.088N | P=0.097N P=0.425N P=0.175N P=0.148N |
|COCHRAN-ARMITAGE | P=0.048N* | P=0.124N |
|FISHER EXACT | P=0.274N P=0.083N P=0.083N | P=0.512N P=0.205N P=0.197N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/69 (3%) 3/68 (4%) 3/69 (4%) 0/69 (0%) | 5/69 (7%) 2/68 (3%) 2/66 (3%) 2/67 (3%) |
|ADJUSTED (b) | 5.2% 8.5% 7.6% 0.0% | 18.5% 6.6% 7.1% 7.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 1/24 (4%) 0/25 (0%) 0/24 (0%) | 4/25 (16%) 1/29 (3%) 2/28 (7%) 2/27 (7%) |
|FIRST INCIDENCE (DAYS) | 543 457 (I) 562 --- | 680 724 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.183N P=0.499 P=0.495 P=0.255N | P=0.172N P=0.173N P=0.188N P=0.189N |
|INCIDENTAL TUMOR | P=0.192N P=0.502 P=0.503 P=0.244N | P=0.164N P=0.176N P=0.189N P=0.179N |
|LOGISTIC REGRESSION | P=0.178N P=0.494 P=0.591 P=0.241N | P=0.179N P=0.175N P=0.213N P=0.194N |
|COCHRAN-ARMITAGE | P=0.165N | P=0.199N |
|FISHER EXACT | P=0.493 P=0.500 P=0.248N | P=0.226N P=0.239N P=0.233N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/69 (13%) 7/68 (10%) 5/69 (7%) 2/69 (3%) | 13/69 (19%) 9/68 (13%) 6/66 (9%) 6/67 (9%) |
|ADJUSTED (b) | 25.3% 21.0% 15.0% 8.3% | 44.9% 26.9% 19.8% 20.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 2/10 (20%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/23 (13%) 3/24 (13%) 2/25 (8%) 2/24 (8%) | 10/25 (40%) 6/29 (21%) 5/28 (18%) 5/27 (19%) |
|FIRST INCIDENCE (DAYS) | 457 456 (I) 562 729 (T) | 583 632 582 676 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.021N* P=0.395N P=0.203N P=0.035N* | P=0.033N* P=0.142N P=0.041N* P=0.042N* |
|INCIDENTAL TUMOR | P=0.021N* P=0.394N P=0.188N P=0.034N* | P=0.031N* P=0.152N P=0.038N* P=0.038N* |
|LOGISTIC REGRESSION | P=0.018N* P=0.407N P=0.173N P=0.031N* | P=0.034N* P=0.156N P=0.057N P=0.042N* |
|COCHRAN-ARMITAGE | P=0.018N* | P=0.055N |
|FISHER EXACT | P=0.408N P=0.199N P=0.028N* | P=0.255N P=0.083N P=0.078N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/69 (3%) 0/67 (0%) 2/68 (3%) 2/68 (3%) | 0/70 (0%) 0/70 (0%) 1/67 (1%) 0/70 (0%) |
|ADJUSTED (b) | 8.0% 0.0% 8.0% 7.5% | 0.0% 0.0% 3.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 2/25 (8%) 1/24 (4%) | 0/26 (0%) 0/30 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 724 --- 729 (T) 716 | --- --- 680 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.453 P=0.240N P=0.667N P=0.685N | P=0.693 (e) P=0.468 (e) |
|INCIDENTAL TUMOR | P=0.408 P=0.273N P=0.680 P=0.629 | P=0.714 (e) P=0.455 (e) |
|LOGISTIC REGRESSION | P=0.442 P=0.234N P=0.697N P=0.695 | P=0.699 (e) P=0.498 (e) |
|COCHRAN-ARMITAGE | P=0.442 | P=0.693 |
|FISHER EXACT | P=0.256N P=0.685 P=0.685 | (e) P=0.489 (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/69 (3%) 1/67 (1%) 2/68 (3%) 2/68 (3%) | 0/70 (0%) 0/70 (0%) 2/67 (3%) 0/70 (0%) |
|ADJUSTED (b) | 8.0% 2.9% 8.0% 7.5% | 0.0% 0.0% 6.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 2/25 (8%) 1/24 (4%) | 0/26 (0%) 0/30 (0%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 724 656 729 (T) 716 | --- --- 680 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.531 P=0.500N P=0.667N P=0.685N | P=0.599 (e) P=0.230 (e) |
|INCIDENTAL TUMOR | P=0.479 P=0.560N P=0.680 P=0.629 | P=0.619 (e) P=0.223 (e) |
|LOGISTIC REGRESSION | P=0.514 P=0.507N P=0.697N P=0.695 | P=0.604 (e) P=0.234 (e) |
|COCHRAN-ARMITAGE | P=0.523 | P=0.593 |
|FISHER EXACT | P=0.511N P=0.685 P=0.685 | (e) P=0.237 (e) |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 0/70 (0%) 1/70 (1%) 0/69 (0%) | 0/70 (0%) 0/70 (0%) 0/68 (0%) 0/70 (0%) |
|ADJUSTED (b) | 7.6% 0.0% 4.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/23 (4%) 0/24 (0%) 1/25 (4%) 0/24 (0%) | 0/26 (0%) 0/30 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 696 --- 729 (T) --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.184N P=0.231N P=0.481N P=0.235N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.196N P=0.253N P=0.500N P=0.263N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.192N P=0.239N P=0.507N P=0.245N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.191N | (e) |
|FISHER EXACT | P=0.248N P=0.500N P=0.252N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 1/70 (1%) 1/70 (1%) 0/69 (0%) | 0/70 (0%) 1/70 (1%) 0/68 (0%) 0/70 (0%) |
|ADJUSTED (b) | 7.6% 4.2% 4.0% 0.0% | 0.0% 2.8% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/23 (4%) 1/24 (4%) 1/25 (4%) 0/24 (0%) | 0/26 (0%) 0/30 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 696 729 (T) 729 (T) --- | --- 674 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.147N P=0.486N P=0.481N P=0.235N | P=0.565N P=0.506 (e) (e) |
|INCIDENTAL TUMOR | P=0.157N P=0.509N P=0.500N P=0.263N | P=0.530N P=0.519 (e) (e) |
|LOGISTIC REGRESSION | P=0.155N P=0.503N P=0.507N P=0.245N | P=0.560N P=0.513 (e) (e) |
|COCHRAN-ARMITAGE | P=0.156N | P=0.567N |
|FISHER EXACT | P=0.500N P=0.500N P=0.252N | P=0.500 (e) (e) |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 0/69 (0%) | 0/70 (0%) 2/70 (3%) 0/68 (0%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 6.7% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 0/25 (0%) 0/24 (0%) | 0/26 (0%) 2/30 (7%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.397N P=0.270 (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.397N P=0.270 (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.397N P=0.270 (e) (e) |
|COCHRAN-ARMITAGE | (e) | P=0.406N |
|FISHER EXACT | (e) (e) (e) | P=0.248 (e) (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 0/69 (0%) | 2/70 (3%) 0/70 (0%) 1/68 (1%) 2/70 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 7.0% 0.0% 2.5% 6.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 0/25 (0%) 0/24 (0%) | 0/26 (0%) 0/30 (0%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 717 --- 598 649 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.483 P=0.221N P=0.497N P=0.672N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.523 P=0.213N P=0.491N P=0.617N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.486 P=0.214N P=0.499N P=0.666N |
|COCHRAN-ARMITAGE | (e) | P=0.469 |
|FISHER EXACT | (e) (e) (e) | P=0.248N P=0.511N P=0.690N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/70 (0%) 0/70 (0%) 0/69 (0%) | 2/70 (3%) 2/70 (3%) 1/68 (1%) 2/70 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 7.0% 6.7% 2.5% 6.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 0/25 (0%) 0/24 (0%) | 0/26 (0%) 2/30 (7%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 717 729 (T) 598 649 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.562N P=0.651N P=0.497N P=0.672N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.528N P=0.651N P=0.491N P=0.617N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.558N P=0.661N P=0.499N P=0.666N |
|COCHRAN-ARMITAGE | (e) | P=0.578N |
|FISHER EXACT | (e) (e) (e) | P=0.690N P=0.511N P=0.690N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 2/70 (3%) 2/70 (3%) 1/69 (1%) | 13/70 (19%) 13/70 (19%) 17/68 (25%) 21/70 (30%) |
|ADJUSTED (b) | 6.8% 5.9% 6.7% 4.2% | 38.8% 35.0% 48.5% 55.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 2/10 (20%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 1/25 (4%) 1/24 (4%) | 7/26 (27%) 8/30 (27%) 11/28 (39%) 13/28 (46%) |
|FIRST INCIDENCE (DAYS) | 670 525 661 729 (T) | 583 629 562 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.383N P=0.687 P=0.686N P=0.503N | P=0.057 P=0.441N P=0.308 P=0.130 |
|INCIDENTAL TUMOR | P=0.417N P=0.664 P=0.659 P=0.556N | P=0.058 P=0.467N P=0.329 P=0.143 |
|LOGISTIC REGRESSION | P=0.390N P=0.694 P=0.687 P=0.514N | P=0.063 P=0.484N P=0.325 P=0.116 |
|COCHRAN-ARMITAGE | P=0.378N | P=0.041 * |
|FISHER EXACT | P=0.690N P=0.690N P=0.505N | P=0.586N P=0.239 P=0.084 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 2/70 (3%) 2/70 (3%) 1/69 (1%) | 13/70 (19%) 15/70 (21%) 17/68 (25%) 21/70 (30%) |
|ADJUSTED (b) | 6.8% 5.9% 6.7% 4.2% | 38.8% 40.9% 48.5% 55.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 2/10 (20%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 1/25 (4%) 1/24 (4%) | 7/26 (27%) 10/30 (33%) 11/28 (39%) 13/28 (46%) |
|FIRST INCIDENCE (DAYS) | 670 525 661 729 (T) | 583 629 562 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.383N P=0.687 P=0.686N P=0.503N | P=0.077 P=0.569 P=0.308 P=0.130 |
|INCIDENTAL TUMOR | P=0.417N P=0.664 P=0.659 P=0.556N | P=0.080 P=0.545 P=0.329 P=0.143 |
|LOGISTIC REGRESSION | P=0.390N P=0.694 P=0.687 P=0.514N | P=0.086 P=0.528 P=0.325 P=0.116 |
|COCHRAN-ARMITAGE | P=0.378N | P=0.057 |
|FISHER EXACT | P=0.690N P=0.690N P=0.505N | P=0.416 P=0.239 P=0.084 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 2/70 (3%) 2/70 (3%) 1/69 (1%) | 14/70 (20%) 15/70 (21%) 18/68 (26%) 21/70 (30%) |
|ADJUSTED (b) | 6.8% 5.9% 6.7% 4.2% | 40.9% 40.9% 49.8% 55.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 2/10 (20%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 1/25 (4%) 1/24 (4%) | 7/26 (27%) 10/30 (33%) 11/28 (39%) 13/28 (46%) |
|FIRST INCIDENCE (DAYS) | 670 525 661 729 (T) | 583 629 562 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.383N P=0.687 P=0.686N P=0.503N | P=0.104 P=0.511N P=0.314 P=0.180 |
|INCIDENTAL TUMOR | P=0.417N P=0.664 P=0.659 P=0.556N | P=0.110 P=0.540N P=0.338 P=0.205 |
|LOGISTIC REGRESSION | P=0.390N P=0.694 P=0.687 P=0.514N | P=0.118 P=0.556N P=0.342 P=0.167 |
|COCHRAN-ARMITAGE | P=0.378N | P=0.078 |
|FISHER EXACT | P=0.690N P=0.690N P=0.505N | P=0.500 P=0.242 P=0.121 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/69 (1%) 1/67 (1%) 2/68 (3%) 1/67 (1%) | 0/70 (0%) 0/70 (0%) 0/67 (0%) 0/70 (0%) |
|ADJUSTED (b) | 4.3% 4.2% 8.0% 4.2% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/23 (4%) 1/24 (4%) 2/25 (8%) 1/24 (4%) | 0/26 (0%) 0/30 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) 729 (T) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.605 P=0.753N P=0.529 P=0.753N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.605 P=0.753N P=0.529 P=0.753N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.605 P=0.753N P=0.529 P=0.753N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.583 | (e) |
|FISHER EXACT | P=0.744 P=0.494 P=0.744 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 18/68 (26%) 12/70 (17%) 18/69 (26%) 13/69 (19%) | 20/70 (29%) 14/70 (20%) 13/67 (19%) 19/70 (27%) |
|ADJUSTED (b) | 48.1% 31.7% 52.4% 42.7% | 56.9% 39.3% 36.2% 46.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/9 (0%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/22 (27%) 4/24 (17%) 9/24 (38%) 8/24 (33%) | 12/26 (46%) 9/30 (30%) 7/28 (25%) 9/28 (32%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 521 459 | 457 (I) 633 582 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.294N P=0.163N P=0.543N P=0.210N | P=0.499N P=0.091N P=0.103N P=0.390N |
|INCIDENTAL TUMOR | P=0.361N P=0.098N P=0.556 P=0.254N | P=0.478N P=0.093N P=0.101N P=0.424N |
|LOGISTIC REGRESSION | P=0.390N P=0.108N P=0.549 P=0.215N | P=0.427N P=0.082N P=0.106N P=0.323N |
|COCHRAN-ARMITAGE | P=0.279N | P=0.512 |
|FISHER EXACT | P=0.131N P=0.557N P=0.194N | P=0.162N P=0.146N P=0.500N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/68 (3%) 0/70 (0%) 0/69 (0%) 0/69 (0%) | 2/70 (3%) 0/70 (0%) 0/67 (0%) 0/70 (0%) |
|ADJUSTED (b) | 7.5% 0.0% 0.0% 0.0% | 6.1% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/22 (5%) 0/24 (0%) 0/24 (0%) 0/24 (0%) | 1/26 (4%) 0/30 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 687 --- --- --- | 521 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.112N P=0.237N P=0.237N P=0.227N | P=0.109N P=0.212N P=0.227N P=0.220N |
|INCIDENTAL TUMOR | P=0.123N P=0.248N P=0.248N P=0.258N | P=0.152N P=0.385N P=0.304N P=0.304N |
|LOGISTIC REGRESSION | P=0.116N P=0.233N P=0.242N P=0.239N | P=0.114N P=0.231N P=0.243N P=0.230N |
|COCHRAN-ARMITAGE | P=0.114N | P=0.117N |
|FISHER EXACT | P=0.241N P=0.245N P=0.245N | P=0.248N P=0.259N P=0.248N |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 20/68 (29%) 12/70 (17%) 18/69 (26%) 13/69 (19%) | 22/70 (31%) 14/70 (20%) 13/67 (19%) 19/70 (27%) |
|ADJUSTED (b) | 52.9% 31.7% 52.4% 42.7% | 60.9% 39.3% 36.2% 46.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 2/10 (20%) 1/10 (10%) 0/10 (0%) 0/9 (0%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/22 (32%) 4/24 (17%) 9/24 (38%) 8/24 (33%) | 13/26 (50%) 9/30 (30%) 7/28 (25%) 9/28 (32%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 456 521 459 | 457 (I) 633 582 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.194N P=0.092N P=0.402N P=0.120N | P=0.372N P=0.043N* P=0.052N P=0.260N |
|INCIDENTAL TUMOR | P=0.240N P=0.047N* P=0.448N P=0.145N | P=0.353N P=0.055N P=0.054N P=0.299N |
|LOGISTIC REGRESSION | P=0.263N P=0.051N P=0.453N P=0.116N | P=0.294N P=0.037N* P=0.037N* P=0.191N |
|COCHRAN-ARMITAGE | P=0.179N | P=0.432N |
|FISHER EXACT | P=0.066N P=0.404N P=0.106N | P=0.088N P=0.078N P=0.355N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/70 (9%) 4/70 (6%) 2/70 (3%) 1/69 (1%) | 0/70 (0%) 1/70 (1%) 0/68 (0%) 0/70 (0%) |
|ADJUSTED (b) | 19.9% 16.7% 8.0% 4.2% | 0.0% 3.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/23 (13%) 4/24 (17%) 2/25 (8%) 1/24 (4%) | 0/26 (0%) 1/30 (3%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 610 729 (T) 729 (T) 729 (T) | --- 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.027N* P=0.365N P=0.130N P=0.063N | P=0.563N P=0.529 (e) (e) |
|INCIDENTAL TUMOR | P=0.029N* P=0.332N P=0.108N P=0.073N | P=0.563N P=0.529 (e) (e) |
|LOGISTIC REGRESSION | P=0.032N* P=0.375N P=0.141N P=0.065N | P=0.563N P=0.529 (e) (e) |
|COCHRAN-ARMITAGE | P=0.032N* | P=0.567N |
|FISHER EXACT | P=0.372N P=0.137N P=0.060N | P=0.500 (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 5/70 (7%) 2/70 (3%) 1/69 (1%) | 1/70 (1%) 0/70 (0%) 1/68 (1%) 1/70 (1%) |
|ADJUSTED (b) | 0.0% 15.4% 8.0% 4.2% | 3.8% 0.0% 3.6% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 2/24 (8%) 2/25 (8%) 1/24 (4%) | 1/26 (4%) 0/30 (0%) 1/28 (4%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- 457 (I) 729 (T) 729 (T) | 729 (T) --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.499N P=0.036 * P=0.256 P=0.508 | P=0.548 P=0.471N P=0.746N P=0.746N |
|INCIDENTAL TUMOR | P=0.524N P=0.038 * P=0.256 P=0.508 | P=0.548 P=0.471N P=0.746N P=0.746N |
|LOGISTIC REGRESSION | P=0.521N P=0.034 * P=0.256 P=0.508 | P=0.548 P=0.471N P=0.746N P=0.746N |
|COCHRAN-ARMITAGE | P=0.506N | P=0.538 |
|FISHER EXACT | P=0.029 * P=0.248 P=0.496 | P=0.500N P=0.745 P=0.752N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 5/70 (7%) 1/70 (1%) 1/69 (1%) | 0/70 (0%) 0/70 (0%) 1/68 (1%) 1/70 (1%) |
|ADJUSTED (b) | 0.0% 15.4% 4.0% 4.2% | 0.0% 0.0% 3.6% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 2/24 (8%) 1/25 (4%) 1/24 (4%) | 0/26 (0%) 0/30 (0%) 1/28 (4%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- 457 (I) 729 (T) 729 (T) | --- --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.475N P=0.036 * P=0.517 P=0.508 | P=0.239 (e) P=0.515 P=0.515 |
|INCIDENTAL TUMOR | P=0.501N P=0.038 * P=0.517 P=0.508 | P=0.239 (e) P=0.515 P=0.515 |
|LOGISTIC REGRESSION | P=0.493N P=0.034 * P=0.517 P=0.508 | P=0.239 (e) P=0.515 P=0.515 |
|COCHRAN-ARMITAGE | P=0.480N | P=0.236 |
|FISHER EXACT | P=0.029 * P=0.500 P=0.496 | (e) P=0.493 P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/70 (9%) 9/70 (13%) 4/70 (6%) 3/69 (4%) | 1/70 (1%) 1/70 (1%) 1/68 (1%) 1/70 (1%) |
|ADJUSTED (b) | 19.9% 30.8% 16.0% 10.1% | 3.8% 3.3% 3.6% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 1/10 (10%) 0/10 (0%) 1/9 (11%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/23 (13%) 6/24 (25%) 4/25 (16%) 2/24 (8%) | 1/26 (4%) 1/30 (3%) 1/28 (4%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 610 457 (I) 729 (T) 456 (I) | 729 (T) 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.095N P=0.296 P=0.348N P=0.254N | P=0.626N P=0.730N P=0.746N P=0.746N |
|INCIDENTAL TUMOR | P=0.106N P=0.322 P=0.315N P=0.283N | P=0.626N P=0.730N P=0.746N P=0.746N |
|LOGISTIC REGRESSION | P=0.111N P=0.283 P=0.384N P=0.265N | P=0.626N P=0.730N P=0.746N P=0.746N |
|COCHRAN-ARMITAGE | P=0.105N | P=0.632 |
|FISHER EXACT | P=0.293 P=0.372N P=0.254N | P=0.752N P=0.745 P=0.752N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 1/70 (1%) 1/70 (1%) 2/69 (3%) | 1/70 (1%) 0/70 (0%) 0/68 (0%) 1/70 (1%) |
|ADJUSTED (b) | 1.9% 2.9% 4.0% 6.6% | 3.8% 0.0% 0.0% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 1/25 (4%) 0/24 (0%) | 1/26 (4%) 0/30 (0%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 457 656 729 (T) 694 | 729 (T) --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.352 P=0.758 P=0.755N P=0.503 | P=0.603 P=0.471N P=0.485N P=0.746N |
|INCIDENTAL TUMOR | P=0.315 P=0.757 P=0.710 P=0.454 | P=0.603 P=0.471N P=0.485N P=0.746N |
|LOGISTIC REGRESSION | P=0.337 P=0.762N P=0.761 P=0.488 | P=0.603 P=0.471N P=0.485N P=0.746N |
|COCHRAN-ARMITAGE | P=0.347 | P=0.594 |
|FISHER EXACT | P=0.752N P=0.752N P=0.495 | P=0.500N P=0.507N P=0.752N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 2/70 (3%) 3/70 (4%) 3/69 (4%) | 2/70 (3%) 1/70 (1%) 1/68 (1%) 1/70 (1%) |
|ADJUSTED (b) | 6.2% 6.9% 11.5% 9.9% | 7.4% 3.3% 2.2% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/23 (4%) 1/24 (4%) 2/25 (8%) 0/24 (0%) | 1/26 (4%) 1/30 (3%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 457 656 726 694 | 726 729 (T) 508 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.379 P=0.687N P=0.526 P=0.509 | P=0.397N P=0.455N P=0.480N P=0.479N |
|INCIDENTAL TUMOR | P=0.327 P=0.688N P=0.458 P=0.444 | P=0.423N P=0.456N P=0.581N P=0.453N |
|LOGISTIC REGRESSION | P=0.349 P=0.694N P=0.491 P=0.480 | P=0.394N P=0.462N P=0.500N P=0.486N |
|COCHRAN-ARMITAGE | P=0.365 | P=0.411N |
|FISHER EXACT | P=0.690N P=0.500 P=0.493 | P=0.500N P=0.511N P=0.500N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 1/70 (1%) 2/70 (3%) 1/69 (1%) | 1/70 (1%) 1/70 (1%) 1/68 (1%) 0/70 (0%) |
|ADJUSTED (b) | 4.3% 4.2% 7.7% 3.6% | 3.7% 3.3% 2.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/23 (4%) 1/24 (4%) 1/25 (4%) 0/24 (0%) | 0/26 (0%) 1/30 (3%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 726 717 | 726 729 (T) 508 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.600 P=0.753N P=0.529 P=0.752N | P=0.303N P=0.733N P=0.749N P=0.493N |
|INCIDENTAL TUMOR | P=0.568 P=0.753N P=0.500 P=0.737 | P=0.338N P=0.734N P=0.673 P=0.448N |
|LOGISTIC REGRESSION | P=0.591 P=0.753N P=0.506 P=0.761 | P=0.304N P=0.741N P=0.760 P=0.491N |
|COCHRAN-ARMITAGE | P=0.586 | P=0.313N |
|FISHER EXACT | P=0.752N P=0.500 P=0.748 | P=0.752N P=0.745 P=0.500N |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 45/70 (64%) 42/68 (62%) 39/70 (56%) 46/69 (67%) | |
|ADJUSTED (b) | 97.7% 100.0% 97.4% 97.8% | |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | |
|INTERIM SACRIFICE 2 (c)| 7/10 (70%) 1/10 (10%) 0/10 (0%) 4/9 (44%) | |
|TERMINAL (d) | 22/23 (96%) 24/24 (100%) 24/25 (96%) 23/24 (96%) | |
|FIRST INCIDENCE (DAYS) | 456 (I) 439 463 431 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.429 P=0.326N P=0.139N P=0.477 | |
|INCIDENTAL TUMOR | P=0.222 P=0.416N P=0.136N P=0.295 | |
|LOGISTIC REGRESSION | P=0.173 P=0.405N P=0.152N P=0.273 | |
|COCHRAN-ARMITAGE | P=0.418 | |
|FISHER EXACT | P=0.448N P=0.194N P=0.454 | |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/69 (13%) 10/70 (14%) 5/67 (7%) 4/68 (6%) | 9/70 (13%) 6/70 (9%) 6/68 (9%) 7/70 (10%) |
|ADJUSTED (b) | 32.7% 33.4% 16.4% 16.7% | 29.8% 19.0% 19.5% 18.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/10 (10%) |
|TERMINAL (d) | 6/23 (26%) 6/24 (25%) 2/25 (8%) 4/24 (17%) | 6/26 (23%) 5/30 (17%) 4/28 (14%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 624 493 515 729 (T) | 659 674 645 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.050N* P=0.518 P=0.177N P=0.110N | P=0.368N P=0.215N P=0.276N P=0.345N |
|INCIDENTAL TUMOR | P=0.058N P=0.521 P=0.223N P=0.124N | P=0.314N P=0.198N P=0.273N P=0.286N |
|LOGISTIC REGRESSION | P=0.058N P=0.491 P=0.218N P=0.124N | P=0.350N P=0.211N P=0.284N P=0.329N |
|COCHRAN-ARMITAGE | P=0.058N | P=0.397N |
|FISHER EXACT | P=0.514 P=0.216N P=0.127N | P=0.293N P=0.314N P=0.396N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/69 (4%) 0/70 (0%) 3/67 (4%) 0/68 (0%) | 1/70 (1%) 1/70 (1%) 0/68 (0%) 1/70 (1%) |
|ADJUSTED (b) | 13.0% 0.0% 10.6% 0.0% | 3.8% 3.3% 0.0% 3.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/23 (13%) 0/24 (0%) 2/25 (8%) 0/24 (0%) | 1/26 (4%) 1/30 (3%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 654 --- | 729 (T) 729 (T) --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.157N P=0.111N P=0.631N P=0.111N | P=0.609N P=0.730N P=0.485N P=0.746N |
|INCIDENTAL TUMOR | P=0.163N P=0.111N P=0.652N P=0.111N | P=0.609N P=0.730N P=0.485N P=0.746N |
|LOGISTIC REGRESSION | P=0.169N P=0.111N P=0.645 P=0.111N | P=0.609N P=0.730N P=0.485N P=0.746N |
|COCHRAN-ARMITAGE | P=0.170N | P=0.616N |
|FISHER EXACT | P=0.120N P=0.646 P=0.125N | P=0.752N P=0.507N P=0.752N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/69 (16%) 10/70 (14%) 8/67 (12%) 4/68 (6%) | 10/70 (14%) 7/70 (10%) 6/68 (9%) 8/70 (11%) |
|ADJUSTED (b) | 40.6% 33.4% 25.8% 16.7% | 33.3% 22.2% 19.5% 22.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/10 (10%) |
|TERMINAL (d) | 8/23 (35%) 6/24 (25%) 4/25 (16%) 4/24 (17%) | 7/26 (27%) 6/30 (20%) 4/28 (14%) 3/28 (11%) |
|FIRST INCIDENCE (DAYS) | 624 493 515 729 (T) | 659 674 645 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.028N* P=0.478N P=0.268N P=0.039N* | P=0.358N P=0.213N P=0.195N P=0.345N |
|INCIDENTAL TUMOR | P=0.033N* P=0.475N P=0.332N P=0.045N* | P=0.306N P=0.198N P=0.190N P=0.288N |
|LOGISTIC REGRESSION | P=0.034N* P=0.511N P=0.343N P=0.047N* | P=0.339N P=0.213N P=0.202N P=0.326N |
|COCHRAN-ARMITAGE | P=0.036N* | P=0.389N |
|FISHER EXACT | P=0.486N P=0.336N P=0.052N | P=0.303N P=0.232N P=0.401N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/69 (3%) 1/70 (1%) 0/67 (0%) 1/68 (1%) | 3/70 (4%) 1/70 (1%) 0/68 (0%) 2/70 (3%) |
|ADJUSTED (b) | 5.5% 2.8% 0.0% 4.2% | 11.5% 3.3% 0.0% 5.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 0/25 (0%) 1/24 (4%) | 3/26 (12%) 1/30 (3%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 465 631 --- 729 (T) | 729 (T) 729 (T) --- 649 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.377N P=0.499N P=0.245N P=0.508N | P=0.430N P=0.254N P=0.107N P=0.465N |
|INCIDENTAL TUMOR | P=0.399N P=0.478N P=0.333N P=0.510N | P=0.408N P=0.254N P=0.107N P=0.432N |
|LOGISTIC REGRESSION | P=0.378N P=0.496N P=0.245N P=0.512N | P=0.428N P=0.254N P=0.107N P=0.463N |
|COCHRAN-ARMITAGE | P=0.373N | P=0.446N |
|FISHER EXACT | P=0.495N P=0.256N P=0.506N | P=0.310N P=0.128N P=0.500N |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/69 (4%) 2/70 (3%) 1/67 (1%) 1/68 (1%) | 3/70 (4%) 2/70 (3%) 1/68 (1%) 2/70 (3%) |
|ADJUSTED (b) | 8.7% 6.0% 4.0% 4.2% | 11.5% 5.3% 3.6% 5.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 0/24 (0%) 1/25 (4%) 1/24 (4%) | 3/26 (12%) 1/30 (3%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 465 631 729 (T) 729 (T) | 729 (T) 544 729 (T) 649 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.206N P=0.493N P=0.308N P=0.315N | P=0.386N P=0.436N P=0.277N P=0.465N |
|INCIDENTAL TUMOR | P=0.237N P=0.513N P=0.397N P=0.337N | P=0.399N P=0.582N P=0.277N P=0.432N |
|LOGISTIC REGRESSION | P=0.212N P=0.497N P=0.320N P=0.319N | P=0.384N P=0.461N P=0.277N P=0.463N |
|COCHRAN-ARMITAGE | P=0.207N | P=0.406N |
|FISHER EXACT | P=0.493N P=0.321N P=0.315N | P=0.500N P=0.321N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 5/70 (7%) 6/70 (9%) 3/68 (4%) 12/70 (17%) |
|ADJUSTED (b) | | 17.9% 15.6% 9.5% 37.3% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/10 (10%) |
|TERMINAL (d) | | 4/26 (15%) 2/30 (7%) 2/28 (7%) 9/28 (32%) |
|FIRST INCIDENCE (DAYS) | | 680 544 622 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.035 * P=0.592 P=0.334N P=0.072 |
|INCIDENTAL TUMOR | | P=0.035 * P=0.476 P=0.315N P=0.083 |
|LOGISTIC REGRESSION | | P=0.035 * P=0.558 P=0.356N P=0.076 |
|COCHRAN-ARMITAGE | | P=0.030 * |
|FISHER EXACT | | P=0.500 P=0.375N P=0.059 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 2/70 (3%) 1/70 (1%) 0/68 (0%) 0/70 (0%) |
|ADJUSTED (b) | | 5.1% 2.4% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/26 (0%) 0/30 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | | 500 633 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.098N P=0.476N P=0.252N P=0.227N |
|INCIDENTAL TUMOR | | P=0.119N P=0.664N P=0.327N P=0.280N |
|LOGISTIC REGRESSION | | P=0.100N P=0.493N P=0.242N P=0.234N |
|COCHRAN-ARMITAGE | | P=0.102N |
|FISHER EXACT | | P=0.500N P=0.255N P=0.248N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 6/70 (9%) 7/70 (10%) 3/68 (4%) 12/70 (17%) |
|ADJUSTED (b) | | 19.7% 17.6% 9.5% 37.3% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/10 (10%) |
|TERMINAL (d) | | 4/26 (15%) 2/30 (7%) 2/28 (7%) 9/28 (32%) |
|FIRST INCIDENCE (DAYS) | | 500 544 622 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.082 P=0.598 P=0.225N P=0.126 |
|INCIDENTAL TUMOR | | P=0.073 P=0.391 P=0.246N P=0.122 |
|LOGISTIC REGRESSION | | P=0.080 P=0.549 P=0.240N P=0.131 |
|COCHRAN-ARMITAGE | | P=0.069 |
|FISHER EXACT | | P=0.500 P=0.261N P=0.103 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 1/70 (1%) 1/70 (1%) 2/69 (3%) | 0/70 (0%) 0/70 (0%) 0/68 (0%) 1/70 (1%) |
|ADJUSTED (b) | 0.0% 4.2% 3.8% 5.3% | 0.0% 0.0% 0.0% 2.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/23 (0%) 1/24 (4%) 0/25 (0%) 0/24 (0%) | 0/26 (0%) 0/30 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 726 543 | --- --- --- 554 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.149 P=0.508 P=0.516 P=0.223 | P=0.208 (e) (e) P=0.522 |
|INCIDENTAL TUMOR | P=0.134 P=0.508 P=0.467 P=0.222 | P=0.193 (e) (e) P=0.500 |
|LOGISTIC REGRESSION | P=0.145 P=0.508 P=0.499 P=0.234 | P=0.199 (e) (e) P=0.500 |
|COCHRAN-ARMITAGE | P=0.150 | P=0.199 |
|FISHER EXACT | P=0.500 P=0.500 P=0.245 | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 10/70 (14%) 9/70 (13%) 10/70 (14%) 10/69 (14%) | 14/70 (20%) 16/70 (23%) 11/68 (16%) 17/70 (24%) |
|ADJUSTED (b) | 29.5% 30.9% 32.1% 33.0% | 38.5% 38.9% 30.5% 42.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/23 (4%) 5/24 (21%) 6/25 (24%) 6/24 (25%) | 6/26 (23%) 6/30 (20%) 5/28 (18%) 7/28 (25%) |
|FIRST INCIDENCE (DAYS) | 610 603 515 508 | 416 625 402 493 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.501 P=0.499N P=0.576N P=0.580 | P=0.421 P=0.555 P=0.330N P=0.448 |
|INCIDENTAL TUMOR | P=0.412 P=0.540N P=0.581 P=0.481 | P=0.455 P=0.469 P=0.314N P=0.423 |
|LOGISTIC REGRESSION | P=0.393 P=0.510N P=0.573 P=0.459 | P=0.490 P=0.575 P=0.321N P=0.502 |
|COCHRAN-ARMITAGE | P=0.497 | P=0.360 |
|FISHER EXACT | P=0.500N P=0.595N P=0.582 | P=0.419 P=0.359N P=0.342 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 2/70 (3%) 0/70 (0%) 0/69 (0%) | 0/70 (0%) 0/70 (0%) 0/68 (0%) 0/70 (0%) |
|ADJUSTED (b) | 14.2% 7.3% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/23 (9%) 1/24 (4%) 0/25 (0%) 0/24 (0%) | 0/26 (0%) 0/30 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 500 684 --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.018N* P=0.331N P=0.060N P=0.068N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.021N* P=0.344N P=0.083N P=0.067N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.019N* P=0.339N P=0.065N P=0.069N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.019N* | (e) |
|FISHER EXACT | P=0.340N P=0.060N P=0.062N | (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 53/70 (76%) 52/70 (74%) 44/70 (63%) 49/69 (71%) | 37/70 (53%) 33/70 (47%) 34/68 (50%) 44/70 (63%) |
|ADJUSTED (b) | 98.1% 100.0% 100.0% 100.0% | 89.8% 78.0% 80.6% 89.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 8/10 (80%) 4/10 (40%) 0/10 (0%) 5/9 (56%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 3/10 (30%) |
|TERMINAL (d) | 22/23 (96%) 24/24 (100%) 25/25 (100%) 24/24 (100%)| 22/26 (85%) 21/30 (70%) 20/28 (71%) 23/28 (82%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 439 463 431 | 435 544 562 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.281N P=0.459N P=0.082N P=0.364N | P=0.152 P=0.118N P=0.303N P=0.320 |
|INCIDENTAL TUMOR | P=0.303N P=0.366N P=0.013N* P=0.476N | P=0.096 P=0.188N P=0.235N P=0.219 |
|LOGISTIC REGRESSION | P=0.429N P=0.396N P=0.012N* P=0.456N | P=0.128 P=0.090N P=0.208N P=0.265 |
|COCHRAN-ARMITAGE | P=0.240N | P=0.081 |
|FISHER EXACT | P=0.500N P=0.071N P=0.332N | P=0.306N P=0.434N P=0.152 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0MG/KG 30MG/KG 60MG/KG 120MG/KG | 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| | 65HUCC M 65HUCC M 65HUCC M 65HUCC M | 65HUCC F 65HUCC F 65HUCC F 65HUCC F |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 25/70 (36%) 20/70 (29%) 24/70 (34%) 15/69 (22%) | 24/70 (34%) 20/70 (29%) 17/68 (25%) 22/70 (31%) |
|ADJUSTED (b) | 63.3% 53.1% 63.4% 44.8% | 59.7% 46.8% 42.1% 53.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 1/10 (10%) 1/10 (10%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) |
|TERMINAL (d) | 9/23 (39%) 8/24 (33%) 12/25 (48%) 7/24 (29%) | 11/26 (42%) 8/30 (27%) 7/28 (25%) 10/28 (36%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 457 (I) 319 508 | 416 544 345 493 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.077N P=0.251N P=0.451N P=0.067N | P=0.368N P=0.185N P=0.141N P=0.321N |
|INCIDENTAL TUMOR | P=0.079N P=0.220N P=0.505N P=0.070N | P=0.349N P=0.378N P=0.143N P=0.357N |
|LOGISTIC REGRESSION | P=0.087N P=0.195N P=0.543N P=0.070N | P=0.288N P=0.158N P=0.120N P=0.240N |
|COCHRAN-ARMITAGE | P=0.063N | P=0.426N |
|FISHER EXACT | P=0.235N P=0.500N P=0.051N | P=0.293N P=0.157N P=0.429N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 54/70 (77%) 52/70 (74%) 45/70 (64%) 49/69 (71%) | 45/70 (64%) 41/70 (59%) 42/68 (62%) 50/70 (71%) |
|ADJUSTED (b) | 98.2% 100.0% 100.0% 100.0% | 93.6% 87.2% 87.4% 94.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/9 (0%) |
|INTERIM SACRIFICE 2 (c)| 9/10 (90%) 4/10 (40%) 0/10 (0%) 5/9 (56%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 3/10 (30%) |
|TERMINAL (d) | 22/23 (96%) 24/24 (100%) 25/25 (100%) 24/24 (100%)| 23/26 (88%) 24/30 (80%) 22/28 (79%) 25/28 (89%) |
|FIRST INCIDENCE (DAYS) | 456 (I) 439 319 431 | 416 544 345 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.250N P=0.405N P=0.085N P=0.313N | P=0.282 P=0.116N P=0.319N P=0.479 |
|INCIDENTAL TUMOR | P=0.201N P=0.231N P=0.015N* P=0.335N | P=0.114 P=0.240N P=0.258N P=0.226 |
|LOGISTIC REGRESSION | P=0.264N P=0.256N P=0.013N* P=0.303N | P=0.255 P=0.052N P=0.279N P=0.510 |
|COCHRAN-ARMITAGE | P=0.199N | P=0.140 |
|FISHER EXACT | P=0.422N P=0.068N P=0.264N | P=0.301N P=0.448N P=0.235 |
|=================================================================================================================================|
DATE: 09/11/94 EXPERIMENT: 05086 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- O-BENZYL-P-CHLOROPHENOL
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 94 456
Female interim sacrifices(days): 94 456
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).