TDMS Study 05086-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus O-BENZYL-P-CHLOROPHENOL DATE: 10/22/97
EXPERIMENT: 05086 TEST: 01 TIME: 12:01:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45042 ROUTE: GAVAGE NTP C#: 61201C
PATHOLOGIST: S. GRUMBEIN CAS: 120-32-1
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0MG/KG M
INCLUDE 004 30MG/KG M
INCLUDE 007 60MG/KG M
INCLUDE 010 120MG/KG M
INCLUDE 013 0MG/KG F
INCLUDE 016 60MG/KG F
INCLUDE 019 120MG/KG F
INCLUDE 022 240MG/KG F
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus O-BENZYL-P-CHLOROPHENOL DATE: 10/22/97
EXPERIMENT: 05086 TEST: 01 TIME: 12:01:43
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45042 ROUTE: GAVAGE NTP C#: 61201C
PATHOLOGIST: S. GRUMBEIN CAS: 120-32-1
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0MG/KG M |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 16 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 457 500 521 533 543 610 624 624 655 660 |
| 670 683 687 687 695 696 711 722 723 724 |
| 726 |
| CENSORED DEATHS |
| 25 37 197 456 456 456 456 456 457 457 |
| 457 457 457 465 467 638 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30MG/KG M |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 24 CENSORED DEATHS 12 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 439 456 493 509 525 525 529 543 547 562 |
| 603 622 631 656 659 660 669 684 711 713 |
| 719 722 723 725 |
| CENSORED DEATHS |
| 32 158 456 456 456 456 456 457 457 457 |
| 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 60MG/KG M |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 15 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 319 463 515 521 554 562 565 579 633 654 |
| 661 661 666 668 676 694 697 701 723 726 |
| CENSORED DEATHS |
| 61 197 274 306 456 456 456 456 456 457 |
| 457 457 457 457 492 |
| |
==================================================================================
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 120MG/KG M |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 14 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 13 150 327 431 459 508 527 541 543 568 |
| 591 641 648 687 687 694 695 716 717 719 |
| 719 720 |
| CENSORED DEATHS |
| 80 122 324 456 456 456 456 456 457 457 |
| 457 457 459 464 |
| |
==================================================================================
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0MG/KG | 100.0 100.0 100.0 100.0 100.0 98.1 89.2 89.2 77.9 52.7 |
|M | |
| | |
|30MG/KG | 100.0 100.0 100.0 100.0 100.0 96.6 84.0 77.7 67.2 50.4 |
|M | |
| | |
|60MG/KG | 100.0 100.0 100.0 98.2 98.2 96.0 91.6 82.6 73.7 55.8 |
|M | |
| | |
|120MG/KG | 98.3 96.6 96.6 94.9 94.9 91.0 82.1 77.7 73.2 53.3 |
|M | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0MG/KG 30MG/KG 60MG/KG 120MG/KG |
| M M M M |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 52.7% 50.4% 55.8% 53.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.959 P=0.741 P=1.000N P=0.905 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 640.5 609.4 611.9 559.1 |
|NATURAL DEATHS (C) | (18.0) (18.9) (22.9) (40.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 610.2 614.6 606.0 589.2 |
|(STANDARD ERROR) | (21.3) (19.2) (20.4) (23.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0MG/KG F |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 12 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 416 435 465 470 500 521 568 577 583 598 |
| 603 628 659 676 680 680 680 682 701 717 |
| 717 726 |
| CENSORED DEATHS |
| 23 317 456 456 456 456 456 457 457 457 |
| 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 60MG/KG F |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 11 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 15 544 610 625 629 632 632 633 646 648 |
| 649 660 663 674 676 676 692 716 724 |
| CENSORED DEATHS |
| 76 456 456 456 456 456 457 457 457 457 |
| 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 120MG/KG F |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 309 345 402 471 508 562 568 579 582 583 |
| 598 622 640 645 649 662 665 666 670 670 |
| 676 680 |
| CENSORED DEATHS |
| 19 456 456 456 456 457 457 457 457 457 |
| |
==================================================================================
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 240MG/KG F |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 11 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 493 541 554 600 619 622 624 632 648 649 |
| 652 659 661 676 680 680 684 687 693 705 |
| 724 |
| CENSORED DEATHS |
| 456 456 456 456 456 457 457 457 457 457 |
| 471 |
| |
==================================================================================
O-BENZYL-P-CHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0MG/KG | 100.0 100.0 100.0 100.0 98.3 92.4 88.2 77.7 73.5 54.6 |
|F | |
| | |
|60MG/KG | 98.3 98.3 98.3 98.3 98.3 98.3 96.3 96.3 73.8 61.5 |
|F | |
| | |
|120MG/KG | 100.0 100.0 100.0 96.6 94.9 92.9 90.9 78.8 66.6 56.5 |
|F | |
| | |
|240MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 95.9 91.8 73.5 57.1 |
|F | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0MG/KG 60MG/KG 120MG/KG 240MG/KG |
| F F F F |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.6% 61.5% 56.5% 57.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.918N P=0.539N P=1.000 P=0.784N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 603.7 618.1 579.6 642.0 |
|NATURAL DEATHS (C) | (21.0) (34.7) (23.2) (12.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 619.0 637.6 621.5 648.9 |
|(STANDARD ERROR) | (18.7) (19.3) (18.6) (13.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
O-BENZYL-P-CHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0MG/KG M = 1
30MG/KG M = 2
60MG/KG M = 3
120MG/KG M = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 3 2 1
| 4 4 3 2 23
| 1 1
| 4 4 23 21 3 1
95 + 4 4 2 2
| 3 1 1
| 4 4 2 2
| 4 4 3 11 3
90 +
| 4 22 1 33 1
| 1 1
| 2 2
P 85 + 3 3
E | 22
R | 4 43 13 1
C | 2 2
E 80 + 24 4 2 3 1 1
N | 3 3
T | 4 2 2 4 11
|
S 75 + 2 244 1 1
U | 2 42 33 11
R |
V | 2 2
I 70 +
V | 33 11
A | 223 3
L |
65 + 2 2
| 1 14
| 2 332
| 1 1
60 + 3 3
| 22
|
| 22 3
55 +
| 4 4
| 1 1
|
50 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 13 obs hidden.
O-BENZYL-P-CHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0MG/KG F = 1
60MG/KG F = 2
120MG/KG F = 3
240MG/KG F = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1 4
| 2 3 3 1 1 2
| 4 4
| 3 3 1 1 2 4 2
95 + 3 11
| 4 4 2 2
| 1 13
| 3 3 4 4
90 + 1 1 22
| 1 31
P | 44
E | 11 44
R 85 + 33
C | 11 2 2
E |
N | 1 1
T 80 + 11 44
| 3 3
S | 1 1 24 2
U | 3 3
R 75 + 1 33 1
V | 1 1
I |
V | 3 3 11
A 70 +
L |
| 2 2
| 33
65 + 42 2
| 22
| 1 1
| 4 1 12 2
60 + 33
| 33 4 4
| 4 4
| 3 11 3
55 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 22 obs hidden.