TDMS Study 05087-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TRIAMTERENE
NTP Experiment-Test: 05087-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/11/94
Route: DOSED FEED Time: 13:32:15
Facility: Battelle Columbus Laboratory
Chemical CAS #: 396-01-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05087-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 13:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 100PPM 200PPM 400PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 20 10
Early Deaths
Moribund Sacrifice 8 5 1 10
Natural Death 4 2 6 7
Survivors
Terminal Sacrifice 37 41 42 43
Moribund Sacrifice 1
Natural Death 1 1 1
Animals Examined Microscopically 70 62 60 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (67) (47) (58) (65)
Inflammation, Chronic Active 1 (2%)
Intestine Large, Colon (68) (50) (59) (69)
Inflammation, Acute 1 (1%)
Intestine Small, Duodenum (67) (50) (60) (69)
Inflammation, Acute 1 (1%)
Ulcer 1 (2%)
Intestine Small, Jejunum (67) (48) (58) (69)
Diverticulum, Single 1 (1%)
Liver (70) (52) (60) (70)
Basophilic Focus 3 (4%) 6 (12%) 6 (10%) 10 (14%)
Basophilic Focus, Multiple 1 (1%)
Clear Cell Focus 1 (2%) 4 (7%) 3 (4%)
Eosinophilic Focus 7 (10%) 11 (21%) 18 (30%) 7 (10%)
Eosinophilic Focus, Multiple 2 (3%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Acute, Necrotizing 4 (7%)
Inflammation, Chronic Active 1 (1%)
Mixed Cell Focus 1 (2%) 1 (1%)
Necrosis, Acute 1 (1%) 1 (1%)
Regeneration 2 (3%)
Thrombosis 1 (2%) 1 (1%)
Vacuolization Cytoplasmic 1 (2%) 2 (3%)
Mesentery (8) (10) (8) (5)
Angiectasis 1 (13%)
Ectopic Tissue 1 (13%)
Inflammation, Chronic Active 2 (25%) 1 (13%)
Fat, Necrosis 2 (25%) 9 (90%) 6 (75%) 3 (60%)
Pancreas (69) (50) (60) (70)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05087-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 13:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 100PPM 200PPM 400PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Vacuolization Cytoplasmic 1 (1%)
Acinus, Atrophy 2 (3%) 3 (6%) 1 (2%) 1 (1%)
Acinus, Cytoplasmic Alteration 2 (3%)
Duct, Ectasia 2 (4%)
Stomach, Forestomach (69) (50) (60) (70)
Acanthosis 2 (3%) 2 (4%) 2 (3%) 7 (10%)
Inflammation, Acute 1 (2%) 3 (4%)
Inflammation, Chronic Active 1 (2%)
Mucosa, Hyperplasia, Diffuse, Papillary 1 (1%)
Stomach, Glandular (69) (50) (60) (70)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%)
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CARDIOVASCULAR SYSTEM
Heart (70) (50) (60) (70)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (70) (50) (60) (70)
Angiectasis 1 (1%)
Cyst 1 (1%) 1 (2%)
Hyperplasia 2 (4%)
Hypertrophy 3 (4%) 3 (6%) 1 (2%) 4 (6%)
Mineralization 1 (1%)
Adrenal Gland, Medulla (67) (50) (60) (69)
Angiectasis 1 (1%)
Mineralization 1 (1%)
Islets, Pancreatic (69) (49) (60) (69)
Hyperplasia 1 (1%) 2 (4%)
Pituitary Gland (68) (47) (57) (68)
Pars Distalis, Cyst 1 (1%) 1 (2%) 3 (4%)
Pars Distalis, Hyperplasia 7 (10%) 3 (6%) 6 (11%) 9 (13%)
Pars Intermedia, Cyst 1 (2%)
Pars Intermedia, Hyperplasia 2 (4%) 1 (2%) 1 (1%)
Pars Intermedia, Hypertrophy 2 (3%)
Thyroid Gland (69) (49) (60) (70)
Inflammation, Chronic Active 1 (2%) 1 (1%)
Follicular Cell, Hyperplasia 4 (6%) 17 (35%) 18 (30%) 28 (40%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05087-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 13:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 100PPM 200PPM 400PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (68) (54) (60) (69)
Angiectasis 1 (1%) 1 (2%) 5 (8%) 1 (1%)
Cyst 18 (26%) 21 (39%) 19 (32%) 26 (38%)
Hemorrhage 1 (1%)
Thrombosis 1 (1%)
Uterus (68) (54) (60) (70)
Angiectasis 1 (2%) 1 (1%)
Dilatation 3 (4%) 4 (7%) 5 (8%) 4 (6%)
Hyperplasia, Cystic, Glandular 38 (56%) 44 (81%) 47 (78%) 53 (76%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (50) (60) (70)
Myelofibrosis 20 (29%) 19 (38%) 19 (32%) 17 (24%)
Lymph Node, Mandibular (66) (49) (59) (68)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis 1 (1%)
Lymphatic, Ectasia 1 (2%)
Lymph Node, Mesenteric (61) (45) (55) (64)
Cyst 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Spleen (69) (50) (58) (70)
Hematopoietic Cell Proliferation 2 (3%) 4 (8%) 5 (9%) 1 (1%)
Necrosis 2 (3%)
Thymus (58) (44) (53) (60)
Necrosis 2 (3%) 4 (7%)
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INTEGUMENTARY SYSTEM
Mammary Gland (55) (43) (53) (61)
Hyperplasia 1 (2%)
Skin (70) (49) (59) (70)
Alopecia 3 (4%) 1 (2%) 1 (2%) 5 (7%)
Hemorrhage 1 (1%)
Inflammation, Chronic Active 1 (1%)
Ulcer 2 (3%) 1 (2%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05087-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 13:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 100PPM 200PPM 400PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (50) (60) (70)
Bilateral, Tarsal, Hyperostosis 1 (2%)
Femur, Cyst 1 (2%)
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NERVOUS SYSTEM
Peripheral Nerve (1)
Degeneration 1 (100%)
Spinal Cord (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (50) (60) (70)
Alveolar Epithelium, Hyperplasia 2 (3%) 1 (2%) 4 (6%)
Nose (70) (50) (60) (70)
Inflammation, Acute 2 (3%) 2 (4%) 7 (10%)
Trachea (70) (50) (60) (70)
Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (3) (3) (2)
Hyperplasia 1 (33%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (61) (60) (70)
Atrophy 1 (1%)
Cyst 1 (1%)
Infarct 1 (2%)
Nephropathy 36 (51%) 39 (64%) 47 (78%) 50 (71%)
Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05087-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 13:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 100PPM 200PPM 400PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 20 10
Early Deaths
Natural Death 2 3 2 8
Moribund Sacrifice 1 2 2 6
Survivors
Terminal Sacrifice 47 45 46 46
Animals Examined Microscopically 70 64 61 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (67) (46) (60) (64)
Inflammation, Chronic Active 1 (1%) 1 (2%) 1 (2%)
Intestine Small, Ileum (69) (49) (59) (65)
Inflammation, Acute 1 (2%)
Peyer's Patch, Necrosis 1 (2%)
Liver (70) (53) (60) (70)
Basophilic Focus 6 (9%) 5 (9%) 11 (18%) 5 (7%)
Basophilic Focus, Multiple 1 (2%)
Clear Cell Focus 1 (1%) 9 (17%) 4 (7%) 10 (14%)
Clear Cell Focus, Multiple 1 (1%)
Eosinophilic Focus 7 (10%) 12 (23%) 11 (18%) 3 (4%)
Hematopoietic Cell Proliferation 1 (1%) 1 (2%)
Inflammation, Chronic Active 1 (1%) 1 (2%)
Necrosis, Acute 1 (2%)
Vacuolization Cytoplasmic 3 (4%) 1 (2%) 1 (2%)
Bile Duct, Cyst 1 (1%)
Bile Duct, Inflammation 1 (2%)
Mesentery (3) (3) (4) (2)
Ectopic Tissue 1 (50%)
Inflammation, Chronic Active 1 (33%) 1 (33%)
Fat, Necrosis 2 (67%) 2 (67%) 3 (75%) 1 (50%)
Pancreas (70) (50) (60) (70)
Inflammation, Chronic Active 1 (1%) 1 (2%)
Acinus, Atrophy 1 (1%)
Acinus, Necrosis, Acute 1 (1%)
Duct, Ectasia 1 (1%)
Stomach, Forestomach (69) (50) (60) (68)
Acanthosis 1 (2%) 3 (5%) 3 (4%)
Diverticulum 1 (2%)
Inflammation, Acute 4 (6%)
Stomach, Glandular (70) (50) (60) (69)
Inflammation, Acute 1 (1%) 2 (3%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05087-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 13:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 100PPM 200PPM 400PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic Active 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (50) (60) (70)
Inflammation, Chronic Active 1 (1%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (70) (50) (60) (69)
Capsule, Hyperplasia 10 (14%) 6 (12%) 3 (5%) 5 (7%)
Adrenal Gland, Cortex (70) (50) (60) (70)
Angiectasis 1 (1%)
Hyperplasia 1 (1%) 2 (4%)
Hypertrophy 26 (37%) 16 (32%) 7 (12%) 16 (23%)
Infarct 1 (2%)
Adrenal Gland, Medulla (69) (50) (58) (70)
Infarct 1 (2%)
Islets, Pancreatic (70) (50) (60) (70)
Hyperplasia 1 (1%) 6 (12%) 1 (2%)
Inflammation, Acute 1 (1%)
Parathyroid Gland (66) (48) (56) (66)
Cyst 1 (2%)
Pituitary Gland (66) (48) (54) (67)
Pars Distalis, Cyst 1 (2%) 4 (8%) 1 (2%) 1 (1%)
Pars Intermedia, Hypertrophy 1 (1%)
Thyroid Gland (70) (50) (60) (70)
Cyst 1 (2%)
Ultimobranchial Cyst 1 (2%)
Follicular Cell, Hyperplasia 3 (4%) 8 (16%) 16 (27%) 20 (29%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (70) (50) (60) (70)
Granuloma Sperm 1 (2%)
Inflammation, Chronic Active 1 (2%)
Preputial Gland (12) (14) (24) (15)
Dilatation 9 (75%) 12 (86%) 22 (92%) 13 (87%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05087-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 13:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 100PPM 200PPM 400PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic Active 3 (25%) 3 (21%) 2 (8%) 2 (13%)
Seminal Vesicle (60) (50) (60) (60)
Dilatation 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 1 (2%)
Testes (70) (50) (60) (70)
Atrophy 1 (2%)
Degeneration 5 (7%) 2 (4%) 2 (3%) 5 (7%)
Granuloma Sperm, Multiple 1 (1%)
Bilateral, Seminiferous Tubule, Atrophy,
Focal 2 (3%) 1 (1%)
Seminiferous Tubule, Atrophy, Focal 4 (6%) 7 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (69) (50) (60) (70)
Myelofibrosis 3 (5%)
Lymph Node (70) (50) (60) (70)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Lymph Node, Mandibular (67) (48) (59) (70)
Necrosis 1 (1%)
Lymph Node, Mesenteric (62) (46) (53) (55)
Congestion 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Necrosis 1 (2%)
Spleen (70) (50) (60) (70)
Fibrosis 1 (1%)
Hematopoietic Cell Proliferation 2 (4%)
Necrosis 4 (6%)
Thymus (56) (40) (46) (49)
Necrosis 7 (14%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (69) (50) (59) (70)
Alopecia 2 (3%) 3 (6%) 1 (2%) 4 (6%)
Inflammation, Chronic Active 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05087-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 13:32:15
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 100PPM 200PPM 400PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (69) (50) (60) (69)
Rib, Cartilage, Fracture Healed 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (51) (60) (70)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (6%) 3 (6%) 2 (3%) 1 (1%)
Bronchiole, Epithelium, Hyperplasia 1 (1%)
Nose (70) (50) (60) (70)
Angiectasis 2 (3%)
Inflammation, Acute 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Angiectasis 1 (100%)
Harderian Gland (3) (3) (6) (2)
Hyperplasia 2 (67%) 2 (67%) 4 (67%)
Inflammation 1 (17%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (64) (61) (70)
Cyst 2 (3%) 3 (4%)
Infarct 2 (3%) 1 (1%)
Inflammation, Acute 1 (2%)
Nephropathy 58 (83%) 61 (95%) 59 (97%) 59 (84%)
Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
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