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https://ntp.niehs.nih.gov/go/3604

TDMS Study 05087-02 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                            TRIAMTERENE


NTP Experiment-Test: 05087-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED FEED                                                                                                 Time: 13:32:15




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  396-01-0

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05087-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8            5            1           10                                     
    Natural Death                                      4            2            6            7                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           41           42           43                                     
    Moribund Sacrifice                                              1                                                               
    Natural Death                                      1            1            1                                                  
  Animals Examined Microscopically                    70           62           60           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (67)         (47)         (58)         (65)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Intestine Large, Colon                             (68)         (50)         (59)         (69)                                   
      Inflammation, Acute                                                                     1 (1%)                                
   Intestine Small, Duodenum                          (67)         (50)         (60)         (69)                                   
      Inflammation, Acute                                                                     1 (1%)                                
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (67)         (48)         (58)         (69)                                   
      Diverticulum, Single                                                                    1 (1%)                                
   Liver                                              (70)         (52)         (60)         (70)                                   
      Basophilic Focus                                 3 (4%)       6 (12%)      6 (10%)     10 (14%)                               
      Basophilic Focus, Multiple                                                              1 (1%)                                
      Clear Cell Focus                                              1 (2%)       4 (7%)       3 (4%)                                
      Eosinophilic Focus                               7 (10%)     11 (21%)     18 (30%)      7 (10%)                               
      Eosinophilic Focus, Multiple                                               2 (3%)                                             
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Acute, Necrotizing                                           4 (7%)                                             
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Mixed Cell Focus                                                           1 (2%)       1 (1%)                                
      Necrosis, Acute                                  1 (1%)                                 1 (1%)                                
      Regeneration                                                               2 (3%)                                             
      Thrombosis                                                    1 (2%)                    1 (1%)                                
      Vacuolization Cytoplasmic                                     1 (2%)       2 (3%)                                             
   Mesentery                                          (8)          (10)         (8)          (5)                                    
      Angiectasis                                                                1 (13%)                                            
      Ectopic Tissue                                   1 (13%)                                                                      
      Inflammation, Chronic Active                     2 (25%)                   1 (13%)                                            
      Fat, Necrosis                                    2 (25%)      9 (90%)      6 (75%)      3 (60%)                               
   Pancreas                                           (69)         (50)         (60)         (70)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05087-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Vacuolization Cytoplasmic                        1 (1%)                                                                       
      Acinus, Atrophy                                  2 (3%)       3 (6%)       1 (2%)       1 (1%)                                
      Acinus, Cytoplasmic Alteration                   2 (3%)                                                                       
      Duct, Ectasia                                                 2 (4%)                                                          
   Stomach, Forestomach                               (69)         (50)         (60)         (70)                                   
      Acanthosis                                       2 (3%)       2 (4%)       2 (3%)       7 (10%)                               
      Inflammation, Acute                                           1 (2%)                    3 (4%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mucosa, Hyperplasia, Diffuse, Papillary          1 (1%)                                                                       
   Stomach, Glandular                                 (69)         (50)         (60)         (70)                                   
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (50)         (60)         (70)                                   
      Inflammation, Chronic Active                                               1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (70)         (50)         (60)         (70)                                   
      Angiectasis                                      1 (1%)                                                                       
      Cyst                                             1 (1%)                    1 (2%)                                             
      Hyperplasia                                                   2 (4%)                                                          
      Hypertrophy                                      3 (4%)       3 (6%)       1 (2%)       4 (6%)                                
      Mineralization                                                                          1 (1%)                                
   Adrenal Gland, Medulla                             (67)         (50)         (60)         (69)                                   
      Angiectasis                                      1 (1%)                                                                       
      Mineralization                                                                          1 (1%)                                
   Islets, Pancreatic                                 (69)         (49)         (60)         (69)                                   
      Hyperplasia                                      1 (1%)       2 (4%)                                                          
   Pituitary Gland                                    (68)         (47)         (57)         (68)                                   
      Pars Distalis, Cyst                              1 (1%)                    1 (2%)       3 (4%)                                
      Pars Distalis, Hyperplasia                       7 (10%)      3 (6%)       6 (11%)      9 (13%)                               
      Pars Intermedia, Cyst                                         1 (2%)                                                          
      Pars Intermedia, Hyperplasia                                  2 (4%)       1 (2%)       1 (1%)                                
      Pars Intermedia, Hypertrophy                                                            2 (3%)                                
   Thyroid Gland                                      (69)         (49)         (60)         (70)                                   
      Inflammation, Chronic Active                                  1 (2%)                    1 (1%)                                
      Follicular Cell, Hyperplasia                     4 (6%)      17 (35%)     18 (30%)     28 (40%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05087-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (68)         (54)         (60)         (69)                                   
      Angiectasis                                      1 (1%)       1 (2%)       5 (8%)       1 (1%)                                
      Cyst                                            18 (26%)     21 (39%)     19 (32%)     26 (38%)                               
      Hemorrhage                                       1 (1%)                                                                       
      Thrombosis                                       1 (1%)                                                                       
   Uterus                                             (68)         (54)         (60)         (70)                                   
      Angiectasis                                                                1 (2%)       1 (1%)                                
      Dilatation                                       3 (4%)       4 (7%)       5 (8%)       4 (6%)                                
      Hyperplasia, Cystic, Glandular                  38 (56%)     44 (81%)     47 (78%)     53 (76%)                               
      Thrombosis                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (70)         (50)         (60)         (70)                                   
      Myelofibrosis                                   20 (29%)     19 (38%)     19 (32%)     17 (24%)                               
   Lymph Node, Mandibular                             (66)         (49)         (59)         (68)                                   
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Necrosis                                                                                1 (1%)                                
      Lymphatic, Ectasia                                                         1 (2%)                                             
   Lymph Node, Mesenteric                             (61)         (45)         (55)         (64)                                   
      Cyst                                                                       1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
      Thrombosis                                                    1 (2%)                                                          
   Spleen                                             (69)         (50)         (58)         (70)                                   
      Hematopoietic Cell Proliferation                 2 (3%)       4 (8%)       5 (9%)       1 (1%)                                
      Necrosis                                                                                2 (3%)                                
   Thymus                                             (58)         (44)         (53)         (60)                                   
      Necrosis                                         2 (3%)                                 4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (43)         (53)         (61)                                   
      Hyperplasia                                                                             1 (2%)                                
   Skin                                               (70)         (49)         (59)         (70)                                   
      Alopecia                                         3 (4%)       1 (2%)       1 (2%)       5 (7%)                                
      Hemorrhage                                       1 (1%)                                                                       
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Ulcer                                            2 (3%)       1 (2%)                    1 (1%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05087-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (70)         (50)         (60)         (70)                                   
      Bilateral, Tarsal, Hyperostosis                               1 (2%)                                                          
      Femur, Cyst                                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                                (1)                                                              
      Degeneration                                                  1 (100%)                                                        
   Spinal Cord                                                     (1)                                                              
      Degeneration                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (50)         (60)         (70)                                   
      Alveolar Epithelium, Hyperplasia                 2 (3%)       1 (2%)                    4 (6%)                                
   Nose                                               (70)         (50)         (60)         (70)                                   
      Inflammation, Acute                              2 (3%)       2 (4%)                    7 (10%)                               
   Trachea                                            (70)         (50)         (60)         (70)                                   
      Inflammation, Acute                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (3)          (3)          (2)                                    
      Hyperplasia                                                                1 (33%)      2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (61)         (60)         (70)                                   
      Atrophy                                          1 (1%)                                                                       
      Cyst                                                                                    1 (1%)                                
      Infarct                                                                    1 (2%)                                             
      Nephropathy                                     36 (51%)     39 (64%)     47 (78%)     50 (71%)                               
      Pigmentation                                                  1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05087-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70           70                                     
  Scheduled Sacrifice                                 20           20           20           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      2            3            2            8                                     
    Moribund Sacrifice                                 1            2            2            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                47           45           46           46                                     
  Animals Examined Microscopically                    70           64           61           70                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (67)         (46)         (60)         (64)                                   
      Inflammation, Chronic Active                     1 (1%)       1 (2%)                    1 (2%)                                
   Intestine Small, Ileum                             (69)         (49)         (59)         (65)                                   
      Inflammation, Acute                                                        1 (2%)                                             
      Peyer's Patch, Necrosis                                                                 1 (2%)                                
   Liver                                              (70)         (53)         (60)         (70)                                   
      Basophilic Focus                                 6 (9%)       5 (9%)      11 (18%)      5 (7%)                                
      Basophilic Focus, Multiple                                    1 (2%)                                                          
      Clear Cell Focus                                 1 (1%)       9 (17%)      4 (7%)      10 (14%)                               
      Clear Cell Focus, Multiple                                                              1 (1%)                                
      Eosinophilic Focus                               7 (10%)     12 (23%)     11 (18%)      3 (4%)                                
      Hematopoietic Cell Proliferation                 1 (1%)       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (1%)       1 (2%)                                                          
      Necrosis, Acute                                               1 (2%)                                                          
      Vacuolization Cytoplasmic                        3 (4%)       1 (2%)       1 (2%)                                             
      Bile Duct, Cyst                                                                         1 (1%)                                
      Bile Duct, Inflammation                                       1 (2%)                                                          
   Mesentery                                          (3)          (3)          (4)          (2)                                    
      Ectopic Tissue                                                                          1 (50%)                               
      Inflammation, Chronic Active                     1 (33%)      1 (33%)                                                         
      Fat, Necrosis                                    2 (67%)      2 (67%)      3 (75%)      1 (50%)                               
   Pancreas                                           (70)         (50)         (60)         (70)                                   
      Inflammation, Chronic Active                     1 (1%)       1 (2%)                                                          
      Acinus, Atrophy                                  1 (1%)                                                                       
      Acinus, Necrosis, Acute                          1 (1%)                                                                       
      Duct, Ectasia                                                                           1 (1%)                                
   Stomach, Forestomach                               (69)         (50)         (60)         (68)                                   
      Acanthosis                                                    1 (2%)       3 (5%)       3 (4%)                                
      Diverticulum                                                  1 (2%)                                                          
      Inflammation, Acute                                                                     4 (6%)                                
   Stomach, Glandular                                 (70)         (50)         (60)         (69)                                   
      Inflammation, Acute                              1 (1%)                    2 (3%)       1 (1%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05087-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic Active                     1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (70)         (50)         (60)         (70)                                   
      Inflammation, Chronic Active                     1 (1%)                                                                       
      Thrombosis                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (70)         (50)         (60)         (69)                                   
      Capsule, Hyperplasia                            10 (14%)      6 (12%)      3 (5%)       5 (7%)                                
   Adrenal Gland, Cortex                              (70)         (50)         (60)         (70)                                   
      Angiectasis                                      1 (1%)                                                                       
      Hyperplasia                                      1 (1%)       2 (4%)                                                          
      Hypertrophy                                     26 (37%)     16 (32%)      7 (12%)     16 (23%)                               
      Infarct                                                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (69)         (50)         (58)         (70)                                   
      Infarct                                                       1 (2%)                                                          
   Islets, Pancreatic                                 (70)         (50)         (60)         (70)                                   
      Hyperplasia                                      1 (1%)       6 (12%)      1 (2%)                                             
      Inflammation, Acute                              1 (1%)                                                                       
   Parathyroid Gland                                  (66)         (48)         (56)         (66)                                   
      Cyst                                                                       1 (2%)                                             
   Pituitary Gland                                    (66)         (48)         (54)         (67)                                   
      Pars Distalis, Cyst                              1 (2%)       4 (8%)       1 (2%)       1 (1%)                                
      Pars Intermedia, Hypertrophy                                                            1 (1%)                                
   Thyroid Gland                                      (70)         (50)         (60)         (70)                                   
      Cyst                                                                       1 (2%)                                             
      Ultimobranchial Cyst                                          1 (2%)                                                          
      Follicular Cell, Hyperplasia                     3 (4%)       8 (16%)     16 (27%)     20 (29%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (70)         (50)         (60)         (70)                                   
      Granuloma Sperm                                                            1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
   Preputial Gland                                    (12)         (14)         (24)         (15)                                   
      Dilatation                                       9 (75%)     12 (86%)     22 (92%)     13 (87%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05087-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                     3 (25%)      3 (21%)      2 (8%)       2 (13%)                               
   Seminal Vesicle                                    (60)         (50)         (60)         (60)                                   
      Dilatation                                       1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Testes                                             (70)         (50)         (60)         (70)                                   
      Atrophy                                                                    1 (2%)                                             
      Degeneration                                     5 (7%)       2 (4%)       2 (3%)       5 (7%)                                
      Granuloma Sperm, Multiple                        1 (1%)                                                                       
      Bilateral, Seminiferous Tubule, Atrophy,                                                                                      
           Focal                                       2 (3%)                                 1 (1%)                                
      Seminiferous Tubule, Atrophy, Focal              4 (6%)                                 7 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (69)         (50)         (60)         (70)                                   
      Myelofibrosis                                                              3 (5%)                                             
   Lymph Node                                         (70)         (50)         (60)         (70)                                   
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (2%)                                                          
   Lymph Node, Mandibular                             (67)         (48)         (59)         (70)                                   
      Necrosis                                                                                1 (1%)                                
   Lymph Node, Mesenteric                             (62)         (46)         (53)         (55)                                   
      Congestion                                                                              1 (2%)                                
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Necrosis                                                                                1 (2%)                                
   Spleen                                             (70)         (50)         (60)         (70)                                   
      Fibrosis                                                                                1 (1%)                                
      Hematopoietic Cell Proliferation                              2 (4%)                                                          
      Necrosis                                                                                4 (6%)                                
   Thymus                                             (56)         (40)         (46)         (49)                                   
      Necrosis                                                                                7 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (69)         (50)         (59)         (70)                                   
      Alopecia                                         2 (3%)       3 (6%)       1 (2%)       4 (6%)                                
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05087-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                            TRIAMTERENE                                        Date: 09/11/94  
Route: DOSED FEED                                                                                                 Time: 13:32:15  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0PPM         100PPM       200PPM       400PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (69)         (50)         (60)         (69)                                   
      Rib, Cartilage, Fracture Healed                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (70)         (51)         (60)         (70)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 4 (6%)       3 (6%)       2 (3%)       1 (1%)                                
      Bronchiole, Epithelium, Hyperplasia                                                     1 (1%)                                
   Nose                                               (70)         (50)         (60)         (70)                                   
      Angiectasis                                                                             2 (3%)                                
      Inflammation, Acute                                                        1 (2%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Cornea, Angiectasis                                                        1 (100%)                                           
   Harderian Gland                                    (3)          (3)          (6)          (2)                                    
      Hyperplasia                                      2 (67%)      2 (67%)      4 (67%)                                            
      Inflammation                                                               1 (17%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (70)         (64)         (61)         (70)                                   
      Cyst                                                                       2 (3%)       3 (4%)                                
      Infarct                                          2 (3%)                                 1 (1%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Nephropathy                                     58 (83%)     61 (95%)     59 (97%)     59 (84%)                               
      Pigmentation                                                  1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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