TDMS Study 05087-03 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TRIAMTERENE
NTP Experiment-Test: 05087-03 Report: PEIRPT03
Study Type: CHRONIC Date: 09/11/94
Route: DOSED FEED Time: 15:25:18
Facility: Battelle Columbus Laboratory
Chemical CAS #: 396-01-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05087-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 15:25:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 10 9
Early Deaths
Natural Death 3 9
Moribund Sacrifice 7 4
Survivors
Terminal Sacrifice 40 38
Animals Examined Microscopically 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (60)
Ulcer 1 (2%)
Muscularis, Degeneration 1 (2%)
Gallbladder (60) (59)
Mucosa, Hyperplasia 1 (2%)
Intestine Small, Ileum (59) (60)
Peyer's Patch, Inflammation, Granulomatous 1 (2%)
Liver (60) (60)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%) 6 (10%)
Clear Cell Focus 4 (7%)
Eosinophilic Focus 10 (17%) 16 (27%)
Infarct 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 2 (3%) 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis, Acute 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Mesentery (2) (7)
Ectopic Tissue 1 (50%)
Artery, Inflammation, Chronic Active 1 (14%)
Fat, Necrosis 1 (50%) 6 (86%)
Pancreas (59) (59)
Cyst 1 (2%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 3 (5%) 1 (2%)
Duct, Ectasia 2 (3%) 1 (2%)
Stomach, Forestomach (60) (60)
Acanthosis 1 (2%) 1 (2%)
Stomach, Glandular (60) (60)
Dysplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05087-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 15:25:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 400 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60)
Degeneration 2 (3%)
Mineralization 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60)
Hypertrophy 3 (5%) 2 (3%)
Adrenal Gland, Medulla (59) (60)
Hyperplasia 1 (2%)
Islets, Pancreatic (59) (57)
Hyperplasia 1 (2%)
Pituitary Gland (59) (56)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 25 (42%) 18 (32%)
Thyroid Gland (60) (60)
Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 9 (15%) 33 (55%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (7) (4)
Dilatation 5 (71%) 4 (100%)
Inflammation 1 (14%)
Ovary (60) (58)
Cyst 15 (25%) 16 (28%)
Cyst, Multiple 1 (2%)
Uterus (60) (60)
Hemorrhage 1 (2%)
Hyperplasia, Cystic, Glandular 52 (87%) 47 (78%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (59)
Myelofibrosis 19 (32%) 19 (32%)
Lymph Node (60) (60)
Lumbar, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05087-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 15:25:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Inflammation, Granulomatous 1 (2%)
Lymph Node, Mandibular (60) (60)
Infiltration Cellular, Histiocyte 1 (2%)
Pigmentation 1 (2%)
Lymph Node, Mesenteric (57) (56)
Congestion 1 (2%)
Cyst 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (2%)
Spleen (59) (60)
Hematopoietic Cell Proliferation 1 (2%) 5 (8%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (3%)
Lymphoid Follicle, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57) (57)
Ectasia 1 (2%)
Hyperplasia 2 (4%) 2 (4%)
Skin (60) (60)
Alopecia 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60)
Compression 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
Arteriole, Infiltration Cellular, Lymphocyte 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60)
Hemorrhage 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%)
Pleura, Infiltration Cellular, Lymphocyte 1 (2%)
Nose (60) (59)
Inflammation, Acute 2 (3%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05087-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 15:25:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0PPM 400 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (4) (4)
Hyperplasia 4 (100%) 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60)
Nephropathy 20 (33%) 24 (40%)
Artery, Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05087-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 15:25:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60
Scheduled Sacrifice 10 10
Early Deaths
Natural Death 4 7
Moribund Sacrifice 3 4
Survivors
Natural Death 1
Terminal Sacrifice 42 39
Animals Examined Microscopically 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (57) (60)
Ulcer 1 (2%)
Intestine Small, Jejunum (59) (59)
Peyer's Patch, Infiltration Cellular,
Histiocyte 1 (2%)
Liver (59) (60)
Basophilic Focus 1 (2%) 7 (12%)
Clear Cell Focus 7 (12%) 5 (8%)
Clear Cell Focus, Multiple 1 (2%)
Congestion 2 (3%)
Eosinophilic Focus 11 (19%) 10 (17%)
Eosinophilic Focus, Multiple 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Infarct 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Regeneration 1 (2%)
Vacuolization Cytoplasmic 2 (3%)
Hepatocyte, Necrosis 1 (2%)
Mesentery (2) (1)
Fat, Necrosis 1 (100%)
Pancreas (58) (60)
Acinus, Atrophy 2 (3%) 4 (7%)
Duct, Cyst 1 (2%)
Stomach, Forestomach (59) (60)
Acanthosis 2 (3%) 2 (3%)
Inflammation, Chronic Active 1 (2%)
Stomach, Glandular (59) (60)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mucosa, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05087-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 15:25:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 400 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (60)
Capsule, Hyperplasia 8 (13%) 1 (2%)
Adrenal Gland, Cortex (60) (60)
Hypertrophy 19 (32%) 8 (13%)
Islets, Pancreatic (57) (59)
Hyperplasia 2 (4%) 2 (3%)
Pituitary Gland (60) (57)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 1 (2%) 3 (5%)
Thyroid Gland (60) (60)
Follicular Cell, Hyperplasia 16 (27%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60)
Granuloma Sperm 1 (2%)
Inflammation, Chronic 1 (2%) 2 (3%)
Inflammation, Chronic Active 1 (2%)
Preputial Gland (41) (37)
Dilatation 36 (88%) 37 (100%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 3 (7%) 1 (3%)
Seminal Vesicle (60) (60)
Inflammation, Acute 1 (2%)
Testes (60) (60)
Degeneration 3 (5%) 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05087-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 15:25:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60)
Myelofibrosis 1 (2%)
Lymph Node, Mesenteric (51) (54)
Congestion 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Inflammation, Granulomatous 2 (4%)
Spleen (57) (60)
Hematopoietic Cell Proliferation 3 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60)
Subcutaneous Tissue, Abscess 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60)
Compression 1 (2%)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (60)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (3%)
Nose (60) (60)
Concretion 1 (2%)
Inflammation, Acute 4 (7%) 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
Inflammation, Acute 1 (100%)
Eye (1) (1)
Cornea, Inflammation, Chronic Active 1 (100%)
Harderian Gland (5) (6)
Hyperplasia 4 (80%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05087-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 15:25:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0PPM 400 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60)
Inflammation, Suppurative 1 (2%)
Nephropathy 55 (92%) 53 (88%)
Urinary Bladder (60) (60)
Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------