TDMS Study 05087-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/11/94
EXP: 05087 TRIAMTERENE TIME: 15:33:45
TEST: 03 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 56042B
CONT: N01-ES-45041 CAS: 396-01-0
PATHOLOGIST: L. MEZZA S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/11/94
EXP: 05087 TRIAMTERENE TIME: 15:33:45
TEST: 03 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 56042B
CONT: N01-ES-45041 CAS: 396-01-0
PATHOLOGIST: L. MEZZA S. EUSTIS
TRIAMTERENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 440 534 622 701 709 712 717 |
| CENSORED DEATHS |
| 463 463 463 463 463 463 463 463 463 463 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 10 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 494 522 554 593 633 666 671 694 701 718 |
| 724 |
| CENSORED DEATHS |
| 463 463 463 463 463 463 463 463 463 463 |
| |
==================================================================================
TRIAMTERENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0PPM | 100.0 100.0 100.0 100.0 100.0 98.3 96.3 96.3 94.3 86.3 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 92.0 90.0 78.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 86.3% 78.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.415 P=0.415 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 633.6 633.6 |
|NATURAL DEATHS (C) | (41.1) (24.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 673.5 667.2 |
|(STANDARD ERROR) | (13.6) (13.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIAMTERENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 10 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 488 534 539 555 616 642 683 701 712 724 |
| CENSORED DEATHS |
| 463 463 463 463 463 463 463 463 463 463 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 9 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 412 534 534 578 605 639 663 673 676 682 |
| 687 687 695 |
| CENSORED DEATHS |
| 463 463 463 463 463 463 463 463 463 |
| |
==================================================================================
TRIAMTERENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0PPM | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 92.0 88.0 80.0 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 100.0 98.3 98.3 94.4 90.5 86.5 74.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 74.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.643 P=0.643 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 619.4 620.4 |
|NATURAL DEATHS (C) | (27.1) (23.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 667.1 666.2 |
|(STANDARD ERROR) | (13.7) (13.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRIAMTERENE
KAPLAN-MEIER SURVIVAL CURVES
0PPM = 1
400 PPM = 2
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
100 + 1 1 2
|
|
| 1 1
98 + 2 2
|
|
| 1 1
96 + 2 2
|
|
| 1 1
94 + 2 2
|
P |
E | 11
R 92 + 2 2
C |
E |
N |
T 90 + 2 2
|
S |
U | 11
R 88 +
V |
I |
V | 1 1
A 86 + 2 2
L |
|
|
84 + 22
|
|
|
82 + 2 2
|
|
|
80 + 22
|
|
|
78 + 2 2
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 1 obs hidden.
TRIAMTERENE
KAPLAN-MEIER SURVIVAL CURVES
0PPM = 1
400 PPM = 2
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100.0 +1 2 1
|
|
| 2 1 1
97.5 +
|
|
|
95.0 +
| 2 2
| 1 1
|
P 92.5 + 2 2
E | 1 1
R |
C | 2 2
E 90.0 + 1 1
N |
T | 2 2
| 1 1
S 87.5 +
U |
R | 2 21 1
V |
I 85.0 +
V |
A | 11
L |
82.5 + 22
| 1 1
|
| 22
80.0 + 1 1
|
|
|
77.5 +
| 22
|
|
75.0 + 2 2
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 2 obs hidden.