TDMS Study 05087-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
TRIAMTERENE
NTP Experiment-Test: 05087-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
Facility: Battelle Columbus Laboratory
Chemical CAS #: 396-01-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 20 20
Early Deaths
Moribund Sacrifice 17 11 12 18
Natural Death 4 5 4 3
Survivors
Terminal Sacrifice 29 34 34 29
Animals Examined Microscopically 70 61 63 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (70) (47) (50) (70)
Ulcer 1 (2%)
Intestine Large, Colon (70) (50) (50) (69)
Parasite Metazoan 2 (3%) 6 (12%) 3 (6%) 4 (6%)
Intestine Large, Rectum (70) (50) (50) (69)
Parasite Metazoan 2 (3%) 1 (1%)
Intestine Small, Duodenum (70) (50) (50) (70)
Ulcer 1 (2%)
Liver (70) (61) (61) (70)
Angiectasis, Focal 1 (1%) 5 (8%)
Basophilic Focus 42 (60%) 45 (74%) 37 (61%) 38 (54%)
Clear Cell Focus 3 (4%) 3 (5%) 4 (7%) 9 (13%)
Degeneration, Cystic 1 (1%)
Eosinophilic Focus 1 (2%) 3 (4%)
Fatty Change 1 (1%) 1 (2%) 3 (4%)
Hepatodiaphragmatic Nodule 2 (3%) 7 (11%) 1 (2%) 7 (10%)
Hyperplasia 1 (1%) 3 (5%) 3 (5%) 2 (3%)
Hyperplasia, Histiocytic, Lymphoid 1 (1%)
Inflammation, Granulomatous 23 (33%) 15 (25%) 22 (36%) 14 (20%)
Mixed Cell Focus 2 (3%) 2 (3%) 9 (15%) 13 (19%)
Necrosis, Coagulative 1 (1%) 2 (3%) 1 (1%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Periportal, Inflammation, Chronic 1 (1%) 1 (1%)
Serosa, Hemorrhage 1 (1%)
Mesentery (4) (2) (4) (1)
Inflammation, Chronic 1 (25%) 1 (50%) 1 (25%)
Fat, Necrosis 3 (75%) 2 (50%)
Pancreas (70) (50) (50) (70)
Inflammation, Chronic 1 (1%)
Acinus, Atrophy 16 (23%) 6 (12%) 11 (22%) 15 (21%)
Artery, Inflammation, Chronic 1 (1%) 1 (2%) 1 (1%)
Salivary Glands (69) (50) (49) (70)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Acute 1 (1%)
Stomach, Forestomach (70) (50) (50) (70)
Acanthosis 2 (3%)
Cyst 1 (2%)
Hyperkeratosis 2 (3%)
Inflammation, Chronic 2 (3%)
Ulcer 2 (3%) 2 (4%) 1 (2%) 3 (4%)
Epithelium, Acanthosis, Diffuse 1 (1%)
Epithelium, Hyperkeratosis, Diffuse 1 (1%)
Stomach, Glandular (70) (50) (50) (70)
Inflammation, Chronic 1 (1%) 1 (1%)
Ulcer 3 (4%) 3 (6%) 3 (6%) 3 (4%)
Mucosa, Mineralization 2 (4%)
Tongue (1) (1)
Acanthosis 1 (100%) 1 (100%)
Hyperkeratosis 1 (100%) 1 (100%)
Tooth (2) (1)
Peridontal Tissue, Inflammation, Chronic 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Inflammation, Chronic 1 (100%)
Heart (70) (50) (50) (70)
Atrium, Thrombosis 2 (4%)
Endothelium, Hyperplasia 1 (1%)
Myocardium, Degeneration 32 (46%) 39 (78%) 30 (60%) 27 (39%)
Myocardium, Degeneration, Multifocal 3 (4%) 3 (4%)
Myocardium, Inflammation, Chronic, Multifocal 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (70) (50) (50) (70)
Hematopoietic Cell Proliferation 1 (1%)
Hyperplasia 13 (19%) 18 (36%) 10 (20%) 16 (23%)
Hyperplasia, Nodular 1 (1%)
Adrenal Gland, Medulla (70) (50) (50) (70)
Hematopoietic Cell Proliferation 1 (1%)
Hyperplasia 6 (9%) 6 (12%) 5 (7%)
Pituitary Gland (70) (53) (52) (69)
Necrosis, Liquifactive 1 (2%)
Pars Distalis, Angiectasis 1 (1%) 3 (6%) 1 (2%)
Pars Distalis, Cyst 6 (9%) 1 (2%) 4 (8%) 6 (9%)
Pars Distalis, Degeneration, Cystic 1 (1%)
Pars Distalis, Hyperplasia 12 (17%) 12 (23%) 9 (17%) 14 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Hyperplasia 1 (1%)
Thyroid Gland (70) (50) (50) (70)
C-Cell, Hyperplasia 52 (74%) 32 (64%) 37 (74%) 43 (61%)
Follicle, Dilatation 2 (4%) 2 (4%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (62) (49) (50) (67)
Inflammation, Chronic 16 (26%) 17 (35%) 28 (56%) 22 (33%)
Inflammation, Suppurative 1 (2%)
Ovary (70) (50) (50) (70)
Cyst 1 (1%) 3 (6%) 1 (2%) 2 (3%)
Inflammation, Granulomatous 1 (1%)
Follicle, Cyst 2 (4%)
Uterus (70) (51) (50) (70)
Dilatation 2 (4%) 1 (2%) 1 (1%)
Hemorrhage 1 (2%)
Cervix, Epithelium, Hyperplasia 2 (3%)
Endometrium, Hyperplasia, Cystic 2 (3%) 2 (4%) 1 (2%)
Vagina (1)
Infiltration Cellular, Polymorphonuclear 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (50) (50) (70)
Femoral, Atrophy 1 (1%)
Femoral, Hyperplasia, Re Cell 10 (14%) 9 (13%)
Femoral, Myelofibrosis 1 (1%)
Lymph Node (70) (51) (50) (70)
Inguinal, Sinus, Ectasia 1 (1%)
Lumbar, Sinus, Ectasia 1 (1%)
Mediastinal, Sinus, Ectasia 2 (3%) 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation 1 (1%)
Pancreatic, Hyperplasia, Plasma Cell 1 (1%)
Pancreatic, Infiltration Cellular, Histiocyte 1 (1%)
Lymph Node, Mandibular (68) (51) (49) (70)
Hyperplasia, Plasma Cell 2 (4%) 1 (2%)
Sinus, Ectasia 2 (4%) 2 (4%) 1 (1%)
Lymph Node, Mesenteric (68) (48) (50) (68)
Infiltration Cellular, Histiocyte 9 (13%) 10 (15%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Sinus, Ectasia 3 (4%) 1 (2%) 4 (6%)
Spleen (70) (50) (50) (70)
Depletion Lymphoid 1 (1%) 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 4 (6%) 1 (2%) 3 (4%)
Hyperplasia, Lymphoid 1 (1%)
Infarct 2 (3%) 2 (4%)
Inflammation, Granulomatous 1 (1%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (67) (49) (49) (66)
Hyperplasia, Cystic 17 (25%) 25 (51%) 22 (45%) 24 (36%)
Skin (70) (50) (50) (70)
Ulcer 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (50) (50) (70)
Osteopetrosis 1 (1%) 5 (10%) 1 (2%)
Femur, Osteopetrosis 2 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (50) (50) (70)
Infarct 3 (4%) 2 (4%) 1 (2%)
Hypothalamus, Compression 10 (14%) 7 (14%) 11 (22%) 14 (20%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (50) (50) (70)
Abscess 1 (1%)
Foreign Body 1 (2%) 1 (1%)
Inflammation, Granulomatous 2 (4%)
Alveolus, Inflammation, Subacute 2 (4%) 1 (2%) 1 (1%)
Interstitium, Inflammation, Chronic 3 (4%) 1 (2%) 3 (6%) 2 (3%)
Peribronchiolar, Inflammation, Chronic,
Multifocal 1 (1%)
Peribronchiolar, Inflammation, Chronic
Active, Multifocal 1 (1%)
Nose (70) (50) (50) (70)
Nares, Inflammation, Suppurative 1 (2%) 3 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (3) (3)
Hemorrhage 1 (33%)
Lens, Cataract 1 (50%) 1 (100%) 2 (67%) 1 (33%)
Harderian Gland (8) (3)
Inflammation, Chronic, Focal 2 (67%)
Inflammation, Chronic, Multifocal 7 (88%)
Inflammation, Chronic Active, Multifocal 1 (13%)
Inflammation, Suppurative 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (60) (60) (70)
Cyst 1 (2%)
Hydronephrosis 1 (1%)
Nephropathy 38 (54%) 45 (75%) 45 (75%) 45 (64%)
Nephropathy, Multifocal 7 (10%) 8 (13%) 5 (8%) 8 (11%)
Renal Tubule, Mineralization, Multifocal 2 (3%)
Urinary Bladder (69) (49) (50) (70)
Transitional Epithelium, Hyperplasia 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Scheduled Sacrifice 20 20 20 20
Early Deaths
Moribund Sacrifice 18 20 18 17
Natural Death 4 5 13 6
Drowned 3
Survivors
Terminal Sacrifice 25 25 19 27
Animals Examined Microscopically 70 60 61 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (70) (51) (50) (70)
Dilatation 1 (2%)
Intestine Large, Cecum (69) (49) (49) (66)
Edema 1 (2%)
Inflammation, Chronic 1 (1%)
Parasite Metazoan 2 (4%)
Ulcer 1 (1%) 1 (2%)
Intestine Large, Colon (70) (51) (48) (68)
Edema 1 (1%)
Mineralization 1 (1%)
Parasite Metazoan 3 (4%) 1 (2%) 5 (10%) 2 (3%)
Intestine Large, Rectum (69) (48) (49) (67)
Edema 1 (1%) 1 (2%)
Mineralization 1 (1%)
Parasite Metazoan 1 (1%) 3 (6%) 2 (4%) 2 (3%)
Intestine Small, Duodenum (70) (50) (50) (68)
Ulcer 1 (2%) 1 (2%)
Intestine Small, Ileum (69) (50) (48) (66)
Mineralization 1 (1%)
Intestine Small, Jejunum (68) (50) (49) (67)
Ulcer 1 (2%)
Liver (70) (56) (55) (69)
Angiectasis, Focal 2 (4%) 1 (1%)
Bacterium 1 (1%) 1 (2%)
Basophilic Focus 16 (23%) 14 (25%) 5 (9%) 23 (33%)
Clear Cell Focus 4 (6%) 6 (11%) 5 (9%) 11 (16%)
Degeneration, Cystic 10 (14%) 7 (13%) 10 (18%) 8 (12%)
Eosinophilic Focus 2 (3%) 3 (5%) 2 (4%) 9 (13%)
Fatty Change 2 (4%)
Fibrosis, Focal 1 (1%)
Hepatodiaphragmatic Nodule 4 (7%) 4 (7%) 3 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia 3 (5%) 5 (9%) 10 (14%)
Inflammation, Granulomatous 7 (10%) 5 (9%) 2 (3%)
Mixed Cell Focus 6 (11%) 9 (16%) 14 (20%)
Necrosis, Coagulative 2 (3%) 2 (4%) 4 (7%) 1 (1%)
Periportal, Inflammation, Chronic 2 (3%)
Sinusoid, Congestion 1 (2%)
Mesentery (4) (4) (4) (10)
Inflammation, Chronic 1 (25%) 2 (20%)
Pigmentation, Hemosiderin 1 (10%)
Fat, Necrosis 3 (75%) 2 (50%) 3 (75%) 5 (50%)
Pancreas (70) (51) (50) (68)
Ectopic Tissue 1 (2%) 1 (1%)
Acinus, Atrophy 16 (23%) 19 (37%) 17 (34%) 17 (25%)
Artery, Inflammation, Chronic 14 (20%) 6 (12%) 11 (22%) 12 (18%)
Duct, Ectasia 1 (1%)
Salivary Glands (70) (50) (50) (70)
Acinus, Parotid Gland, Cytoplasmic
Alteration, Focal 1 (1%)
Acinus, Parotid Gland, Vacuolization
Cytoplasmic, Focal 1 (1%)
Periductular, Fibrosis 1 (2%)
Stomach, Forestomach (70) (51) (51) (69)
Acanthosis 3 (6%) 4 (6%)
Hyperkeratosis 3 (6%) 4 (6%)
Inflammation, Chronic 2 (4%) 1 (2%) 2 (3%)
Inflammation, Chronic, Focal 1 (1%)
Inflammation, Focal, Subacute 1 (1%)
Mineralization 2 (3%) 1 (2%)
Ulcer 2 (3%) 6 (12%) 2 (4%) 3 (4%)
Epithelium, Acanthosis, Focal 2 (3%)
Epithelium, Hyperkeratosis, Focal 2 (3%) 1 (2%)
Stomach, Glandular (70) (51) (50) (68)
Inflammation, Chronic 4 (6%) 1 (2%)
Inflammation, Focal, Subacute 1 (1%)
Ulcer 8 (11%) 6 (12%) 4 (8%) 3 (4%)
Mucosa, Hyperplasia, Focal 1 (1%)
Mucosa, Mineralization 7 (10%) 3 (6%) 7 (14%) 4 (6%)
Tongue (1) (1) (1)
Acanthosis 1 (100%)
Hyperkeratosis 1 (100%)
Tooth (1) (1) (1)
Peridontal Tissue, Inflammation, Chronic 1 (100%)
Pulp, Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (3) (3) (3)
Aorta, Inflammation, Chronic 1 (33%)
Aorta, Inflammation, Chronic, Focal 1 (33%)
Aorta, Mineralization 1 (100%) 3 (100%) 3 (100%) 1 (33%)
Heart (70) (60) (60) (70)
Atrium, Dilatation 1 (1%)
Atrium, Thrombosis 1 (1%) 1 (2%)
Coronary Artery, Inflammation, Chronic 1 (2%)
Myocardium, Degeneration 34 (49%) 44 (73%) 42 (70%) 36 (51%)
Myocardium, Degeneration, Multifocal 6 (9%) 7 (12%) 6 (10%) 10 (14%)
Myocardium, Inflammation, Chronic, Multifocal 9 (13%) 3 (4%)
Myocardium, Inflammation, Suppurative 1 (1%)
Myocardium, Mineralization 2 (3%) 2 (3%) 3 (5%) 3 (4%)
Valve, Inflammation, Chronic Active 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (70) (51) (50) (70)
Angiectasis 1 (2%)
Ectopic Tissue 1 (2%)
Hemorrhage 1 (1%)
Hyperplasia 8 (11%) 14 (27%) 18 (36%) 14 (20%)
Hyperplasia, Nodular 1 (1%)
Adrenal Gland, Medulla (70) (51) (50) (69)
Hyperplasia 12 (17%) 14 (27%) 16 (32%) 6 (9%)
Infarct 1 (1%) 1 (2%)
Parathyroid Gland (64) (47) (50) (68)
Hyperplasia 4 (6%) 3 (6%) 11 (22%) 8 (12%)
Pituitary Gland (70) (52) (49) (69)
Abscess 1 (1%)
Pars Distalis, Cyst 2 (4%) 1 (1%)
Pars Distalis, Hyperplasia 10 (14%) 5 (10%) 7 (14%) 6 (9%)
Pars Distalis, Hyperplasia, Nodular 1 (1%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (70) (50) (50) (69)
C-Cell, Hyperplasia 43 (61%) 32 (64%) 28 (56%) 44 (64%)
Follicle, Dilatation 3 (4%) 2 (4%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (70) (51) (50) (69)
Granuloma Sperm 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Preputial Gland (70) (51) (51) (67)
Hyperplasia 3 (6%) 3 (6%)
Inflammation, Chronic 44 (63%) 39 (76%) 40 (78%) 47 (70%)
Duct, Dilatation 1 (2%)
Prostate (68) (49) (50) (69)
Cyst 1 (2%)
Inflammation, Chronic 5 (7%) 1 (1%)
Inflammation, Suppurative 23 (34%) 17 (35%) 13 (26%) 22 (32%)
Seminal Vesicle (69) (48) (50) (69)
Inflammation, Suppurative 1 (1%) 2 (4%)
Testes (70) (51) (56) (69)
Necrosis, Coagulative 1 (1%)
Interstitial Cell, Hyperplasia 4 (6%) 1 (2%) 1 (2%) 1 (1%)
Interstitial Cell, Right, Hyperplasia 1 (1%)
Seminiferous Tubule, Atrophy 12 (17%) 15 (29%) 12 (21%) 7 (10%)
Seminiferous Tubule, Hypoplasia 1 (1%)
Seminiferous Tubule, Right, Atrophy 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (51) (50) (70)
Hyperplasia, Histiocytic 1 (1%)
Lymph Node (70) (51) (50) (70)
Mediastinal, Pigmentation, Hemosiderin 1 (1%) 1 (2%)
Mediastinal, Sinus, Ectasia 1 (1%) 1 (2%) 1 (1%)
Renal, Ectasia 2 (4%)
Renal, Sinus, Ectasia 1 (2%)
Lymph Node, Mandibular (70) (50) (50) (70)
Hyperplasia, Lymphoid 1 (1%)
Hyperplasia, Plasma Cell 1 (1%) 2 (4%) 1 (2%)
Infiltration Cellular, Histiocyte 2 (3%)
Sinus, Ectasia 1 (2%) 2 (3%)
Lymph Node, Mesenteric (68) (48) (47) (67)
Hyperplasia, Plasma Cell 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Infiltration Cellular, Histiocyte 7 (10%) 1 (2%) 5 (7%)
Sinus, Ectasia 3 (6%) 1 (2%) 1 (1%)
Spleen (70) (51) (50) (70)
Depletion Lymphoid 1 (1%)
Fibrosis 4 (6%) 6 (12%) 4 (8%) 8 (11%)
Hematopoietic Cell Proliferation 1 (1%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (2%)
Infarct 1 (1%) 1 (2%) 1 (2%) 4 (6%)
Inflammation, Granulomatous 1 (2%)
Thymus (62) (47) (46) (60)
Atrophy 1 (2%)
Ectopic Parathyroid Gland 1 (2%)
Ectopic Thyroid 1 (2%)
Inflammation, Chronic 1 (2%)
Arteriole, Giant Cell 1 (2%)
Artery, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (38) (35) (57)
Hyperplasia, Cystic 17 (34%) 5 (13%) 5 (14%) 8 (14%)
Skin (69) (51) (50) (68)
Abscess 1 (1%) 2 (4%) 1 (2%)
Cyst Epithelial Inclusion 3 (6%) 1 (1%)
Hemorrhage 1 (1%)
Ulcer 1 (2%) 1 (2%)
Epidermis, Acanthosis 1 (2%) 1 (1%)
Epidermis, Hyperkeratosis 1 (2%) 1 (1%)
Hair Follicle, Hyperkeratosis 1 (2%)
Sebaceous Gland, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (51) (50) (70)
Osteopetrosis 1 (1%)
Femur, Fibrous Osteodystrophy 4 (6%) 3 (6%) 5 (10%) 2 (3%)
Femur, Osteopetrosis 1 (1%)
Synovial Tissue, Inflammation, Suppurative 1 (1%) 1 (1%)
Tarsal, Fracture Healed 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (51) (50) (70)
Gliosis 1 (1%)
Hydrocephalus 1 (1%)
Infarct 3 (4%) 1 (2%) 6 (12%) 2 (3%)
Inflammation, Suppurative 1 (1%)
Hypothalamus, Compression 4 (6%) 4 (8%) 2 (4%) 3 (4%)
Spinal Cord (1)
Lumbar, Atrophy 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (51) (50) (70)
Inflammation, Granulomatous 1 (1%)
Alveolus, Hemorrhage, Multifocal 1 (1%)
Alveolus, Inflammation, Subacute 1 (2%) 2 (3%)
Artery, Mineralization, Focal 1 (1%)
Bronchus, Foreign Body, Single 1 (1%)
Bronchus, Epithelium, Hyperplasia, Multifocal 1 (1%)
Interstitium, Inflammation, Chronic 2 (3%) 2 (4%) 3 (6%) 4 (6%)
Interstitium, Inflammation, Chronic, Focal 1 (1%)
Interstitium, Mineralization 2 (3%) 2 (4%) 2 (4%)
Peribronchial, Inflammation, Chronic, Focal 1 (1%)
Peribronchiolar, Inflammation, Chronic,
Multifocal 4 (6%)
Nose (70) (51) (50) (70)
Fungus 1 (1%) 1 (1%)
Nares, Foreign Body 1 (2%)
Nares, Inflammation, Suppurative 3 (4%) 2 (4%) 2 (3%)
Sinus, Inflammation, Chronic Active 1 (1%)
Trachea (70) (51) (50) (70)
Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (1)
Middle Ear, Abscess 1 (50%)
Eye (3) (2) (1) (2)
Phthisis Bulbi 1 (33%)
Cornea, Inflammation, Necrotizing 1 (100%)
Cornea, Mineralization 1 (33%) 1 (50%)
Lens, Cataract 1 (33%) 1 (50%) 1 (50%)
Sclera, Mineralization 1 (50%)
Harderian Gland (2) (1)
Inflammation, Chronic, Multifocal 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (51) (52) (70)
Cyst 1 (1%) 2 (4%) 2 (4%) 1 (1%)
Hydronephrosis 1 (1%)
Inflammation, Suppurative 1 (1%)
Nephropathy 47 (67%) 49 (96%) 50 (96%) 49 (70%)
Nephropathy, Multifocal 10 (14%) 1 (2%) 2 (4%) 10 (14%)
Interstitial Tissue, Inflammation, Chronic,
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Multifocal 4 (6%)
Urinary Bladder (69) (48) (50) (67)
Ectasia 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Necrotizing 1 (1%)
Inflammation, Suppurative 1 (1%)
Lumen, Hemorrhage 2 (3%) 3 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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