TDMS Study 05087-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
TRIAMTERENE
NTP Experiment-Test: 05087-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/11/94
Route: DOSED FEED Time: 11:14:46
Facility: Battelle Columbus Laboratory
Chemical CAS #: 396-01-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Scheduled Sacrifice 20 20 20 20
Early Deaths
Moribund Sacrifice 17 11 12 18
Natural Death 4 5 4 3
Survivors
Terminal Sacrifice 29 34 34 29
Animals Examined Microscopically 70 61 63 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (70) (61) (61) (70)
Hepatocellular Adenoma 1 (1%)
Hepatocellular Adenoma, Multiple 1 (1%)
Mesentery (4) (2) (4) (1)
Pancreas (70) (50) (50) (70)
Stomach, Forestomach (70) (50) (50) (70)
Stomach, Glandular (70) (50) (50) (70)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (50) (50) (70)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (70) (50) (50) (70)
Adenoma 2 (3%) 1 (2%)
Adrenal Gland, Medulla (70) (50) (50) (70)
Pheochromocytoma Malignant 1 (1%) 1 (2%)
Pheochromocytoma Benign 1 (2%) 1 (1%)
Islets, Pancreatic (70) (50) (50) (70)
Adenoma 3 (4%) 2 (4%) 1 (1%)
Pituitary Gland (70) (53) (52) (69)
Pars Distalis, Adenoma 22 (31%) 21 (40%) 25 (48%) 28 (41%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (70) (50) (50) (70)
C-Cell, Adenoma 5 (7%) 11 (22%) 5 (10%) 10 (14%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (2%)
Page 2
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Follicle, Adenocarcinoma 1 (2%)
Follicle, Adenoma 1 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Chemodectoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (62) (49) (50) (67)
Adenoma 3 (5%) 3 (6%) 4 (8%) 2 (3%)
Carcinoma 1 (2%)
Bilateral, Adenoma 1 (1%)
Ovary (70) (50) (50) (70)
Granulosa Cell Tumor Malignant 1 (1%)
Granulosa Cell Tumor Benign 1 (1%)
Uterus (70) (51) (50) (70)
Leiomyoma 2 (3%)
Polyp Stromal 5 (7%) 7 (14%) 5 (10%) 5 (7%)
Cervix, Squamous Cell Carcinoma 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (50) (50) (70)
Lymph Node (70) (51) (50) (70)
Lymph Node, Mandibular (68) (51) (49) (70)
Lymph Node, Mesenteric (68) (48) (50) (68)
Spleen (70) (50) (50) (70)
Thymus (64) (46) (46) (65)
Mediastinum, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (67) (49) (49) (66)
Adenoma 4 (6%) 4 (8%) 1 (2%)
Fibroadenoma 16 (24%) 11 (22%) 14 (29%) 12 (18%)
Fibroadenoma, Multiple 4 (6%) 5 (10%) 2 (4%) 1 (2%)
Skin (70) (50) (50) (70)
Keratoacanthoma 1 (1%)
Subcutaneous Tissue, Fibroma 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (1%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (1%)
Page 3
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (50) (50) (70)
Peripheral Nerve (1) (1)
Sciatic, Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (50) (50) (70)
Adenocarcinoma, Metastatic, Thyroid Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (1%) 2 (4%) 1 (1%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Granulosa Cell Tumor Malignant, Metastatic,
Ovary 1 (1%)
Mediastinum, Schwannoma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
Pinna, Fibroma 1 (100%)
Pinna, Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (60) (60) (70)
Urinary Bladder (69) (49) (50) (70)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(61) *(63) *(70)
Leukemia Mononuclear 8 (11%) 11 (18%) 7 (11%) 9 (13%)
Mesothelioma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 45 42 42
Total Primary Neoplasms 84 77 74 81
Total Animals with Benign Neoplasms 43 39 40 37
Total Benign Neoplasms 65 64 65 70
Total Animals with Malignant Neoplasms 16 13 9 10
Total Malignant Neoplasms 19 13 9 11
Total Animals with Metastatic Neoplasms 1 2
Total Metastatic Neoplasm 1 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70
Scheduled Sacrifice 20 20 20 20
Early Deaths
Moribund Sacrifice 18 20 18 17
Natural Death 4 5 13 6
Drowned 3
Survivors
Terminal Sacrifice 25 25 19 27
Animals Examined Microscopically 70 60 61 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (69) (48) (49) (67)
Adenocarcinoma 1 (1%)
Adenoma 1 (2%)
Intestine Small, Jejunum (68) (50) (49) (67)
Adenoma 1 (2%)
Liver (70) (56) (55) (69)
Cholangioma 1 (1%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hepatocellular Adenoma 4 (7%) 4 (7%) 2 (3%)
Hepatocellular Adenoma, Multiple 2 (4%) 1 (1%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (4) (4) (4) (10)
Lipoma 1 (25%)
Pancreas (70) (51) (50) (68)
Stomach, Forestomach (70) (51) (51) (69)
Squamous Cell Papilloma 1 (2%) 1 (1%)
Stomach, Glandular (70) (51) (50) (68)
Tongue (1) (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%)
Tooth (1) (1) (1)
Gingiva, Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (60) (60) (70)
Chemodectoma Benign 1 (2%)
Hemangiosarcoma 1 (1%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (70) (51) (50) (70)
Adenoma 1 (1%) 1 (2%)
Adrenal Gland, Medulla (70) (51) (50) (69)
Pheochromocytoma Malignant 1 (1%) 2 (4%)
Pheochromocytoma Benign 8 (11%) 10 (20%) 7 (14%) 5 (7%)
Bilateral, Pheochromocytoma Benign 2 (3%) 1 (2%) 1 (2%) 2 (3%)
Islets, Pancreatic (70) (51) (50) (69)
Adenoma 2 (3%) 1 (2%) 5 (10%) 1 (1%)
Parathyroid Gland (64) (47) (50) (68)
Adenoma 1 (2%)
Pituitary Gland (70) (52) (49) (69)
Pars Distalis, Adenoma 8 (11%) 7 (13%) 7 (14%) 9 (13%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (70) (50) (50) (69)
Bilateral, C-Cell, Adenoma 1 (1%) 1 (2%) 1 (2%) 1 (1%)
C-Cell, Adenoma 10 (14%) 6 (12%) 11 (22%) 9 (13%)
Follicle, Adenoma 1 (1%) 1 (2%) 2 (4%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Chemodectoma Benign 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (70) (51) (50) (69)
Preputial Gland (70) (51) (51) (67)
Adenoma 3 (4%) 2 (4%) 5 (10%) 3 (4%)
Prostate (68) (49) (50) (69)
Seminal Vesicle (69) (48) (50) (69)
Testes (70) (51) (56) (69)
Bilateral, Interstitial Cell, Adenoma 43 (61%) 43 (84%) 48 (86%) 49 (71%)
Interstitial Cell, Adenoma 9 (13%) 5 (10%) 7 (13%) 8 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (51) (50) (70)
Lymph Node (70) (51) (50) (70)
Pancreatic, Pheochromocytoma Malignant,
Metastatic, Adrenal Gland 1 (1%)
Lymph Node, Mandibular (70) (50) (50) (70)
Lymph Node, Mesenteric (68) (48) (47) (67)
Page 7
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Spleen (70) (51) (50) (70)
Leiomyosarcoma 2 (3%)
Thymus (62) (47) (46) (60)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (38) (35) (57)
Fibroadenoma 1 (2%)
Skin (69) (51) (50) (68)
Basal Cell Adenoma 1 (2%) 1 (2%)
Basal Cell Carcinoma 1 (2%)
Basosquamous Tumor Malignant 2 (3%)
Basosquamous Tumor Benign 1 (2%) 1 (1%)
Keratoacanthoma 2 (3%) 2 (4%) 1 (2%) 1 (1%)
Squamous Cell Papilloma 1 (1%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (1%) 2 (4%) 3 (6%) 2 (3%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (51) (50) (70)
Osteosarcoma 1 (2%) 1 (2%) 1 (1%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (51) (50) (70)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Granular Cell Tumor Benign 1 (1%)
Oligodendroglioma Benign 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (51) (50) (70)
Alveolar/Bronchiolar Adenoma 2 (3%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Gland 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (70) (51) (50) (70)
Squamous Cell Papilloma 1 (2%)
Page 8
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (1)
Middle Ear, Squamous Cell Papilloma 1 (50%)
Pinna, Fibrosarcoma 1 (100%)
Pinna, Squamous Cell Papilloma 1 (50%)
Zymbal's Gland (1) (2)
Adenoma 1 (100%)
Carcinoma 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (51) (52) (70)
Adenoma 1 (1%) 1 (2%)
Liposarcoma 1 (2%)
Urinary Bladder (69) (48) (50) (67)
Adenoma 1 (1%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(60) *(61) *(70)
Leukemia Mononuclear 22 (31%) 23 (38%) 19 (31%) 18 (26%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Mixed 1 (1%)
Mesothelioma Malignant 2 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05087-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TRIAMTERENE Date: 09/11/94
Route: DOSED FEED Time: 11:14:46
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 150 PPM 300 PPM 600 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 55 52 58 60
Total Primary Neoplasms 128 127 136 125
Total Animals with Benign Neoplasms 54 50 58 58
Total Benign Neoplasms 100 95 111 100
Total Animals with Malignant Neoplasms 26 29 24 23
Total Malignant Neoplasms 28 32 25 25
Total Animals with Metastatic Neoplasms 1 3 3
Total Metastatic Neoplasm 1 3 4
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------