TDMS Study 05087-01 Pathology Tables
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
Facility: Battelle Columbus Laboratory
Chemical CAS #: 396-01-0
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 0| 7| 0| 0| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 0| 4| 4| 5| 0| 7| 7| 4| 7|
DAY ON TEST | 9| 0| 9| 9| 6| 0| 0| 3| 2| 2| 3| 7| 5| 2| 5| 2| 9| 5| 5| 9| 9| 2| 0| 5| 2|
| 6| 8| 3| 5| 0| 7| 4| 1| 9| 9| 1| 3| 6| 9| 6| 9| 6| 6| 6| 6| 4| 9| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X |
Fatty Change | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Histiocytic, Lymphoid | 4 |
Hyperplasia | |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 |
Mixed Cell Focus | |
Necrosis, Coagulative | 3 |
Periportal, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 2 |
Fat, Necrosis | 1 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Acinus, Atrophy | 2 1 1 1 1 1 3 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
Ulcer | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ulcer | 1 1 |
__________________________________________________________________________|
Tongue | |
Acanthosis | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 0| 7| 0| 0| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 0| 4| 4| 5| 0| 7| 7| 4| 7|
DAY ON TEST | 9| 0| 9| 9| 6| 0| 0| 3| 2| 2| 3| 7| 5| 2| 5| 2| 9| 5| 5| 9| 9| 2| 0| 5| 2|
| 6| 8| 3| 5| 0| 7| 4| 1| 9| 9| 1| 3| 6| 9| 6| 9| 6| 6| 6| 6| 4| 9| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endothelium, Hyperplasia | |
Myocardium, Degeneration | 2 1 1 2 1 1 2 1 3|
Myocardium, Degeneration, Multifocal | 1 |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 2 2 1 |
Hyperplasia, Nodular | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M M + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 3 3 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 2 2 2 3 2 1 2 1 2 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + M M + + + + + + + M + + + + +|
Inflammation, Chronic | 1 1 1 1 1 2 1 1|
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Epithelium, Hyperplasia | 2 3 |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 0| 7| 0| 0| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 0| 4| 4| 5| 0| 7| 7| 4| 7|
DAY ON TEST | 9| 0| 9| 9| 6| 0| 0| 3| 2| 2| 3| 7| 5| 2| 5| 2| 9| 5| 5| 9| 9| 2| 0| 5| 2|
| 6| 8| 3| 5| 0| 7| 4| 1| 9| 9| 1| 3| 6| 9| 6| 9| 6| 6| 6| 6| 4| 9| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Atrophy | |
Femoral, Hyperplasia, Re Cell | 1 2 2 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Sinus, Ectasia | |
Mediastinal, Sinus, Ectasia | 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 1 2 3 |
Sinus, Ectasia | 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | 1 |
Infarct | 3 2 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + M + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Cystic | 2 3 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
Femur, Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 2 3 |
Hypothalamus, Compression | 3 4|
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitium, Inflammation, Chronic | 1|
Peribronchiolar, Inflammation, | |
Chronic, Multifocal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 0| 7| 0| 0| 6| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 0| 4| 4| 5| 0| 7| 7| 4| 7|
DAY ON TEST | 9| 0| 9| 9| 6| 0| 0| 3| 2| 2| 3| 7| 5| 2| 5| 2| 9| 5| 5| 9| 9| 2| 0| 5| 2|
| 6| 8| 3| 5| 0| 7| 4| 1| 9| 9| 1| 3| 6| 9| 6| 9| 6| 6| 6| 6| 4| 9| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + + + |
Inflammation, Chronic, Multifocal | 1 1 1 |
Inflammation, Chronic Active, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 2 2 1 1 1 1 1|
Nephropathy, Multifocal | 1 1 1 |
Renal Tubule, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 0| 5| 7| 6| 7| 7| 7| 7| 7| 0| 4| 7| 4| 7| 6| 7| 7| 4| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 7| 9| 7| 2| 9| 1| 3| 0| 3| 3| 9| 5| 0| 5| 3| 7| 3| 3| 5| 7| 3|
| 4| 9| 9| 9| 6| 6| 1| 9| 8| 5| 0| 4| 0| 0| 3| 6| 4| 1| 0| 1| 0| 0| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Fatty Change | 4 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Histiocytic, Lymphoid | |
Hyperplasia | 2 |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 |
Mixed Cell Focus | X |
Necrosis, Coagulative | |
Periportal, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy | 1 2 1 2 1|
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2|
Hyperkeratosis | 2|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | 1 |
__________________________________________________________________________|
Tongue | + |
Acanthosis | 2 |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 0| 5| 7| 6| 7| 7| 7| 7| 7| 0| 4| 7| 4| 7| 6| 7| 7| 4| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 7| 9| 7| 2| 9| 1| 3| 0| 3| 3| 9| 5| 0| 5| 3| 7| 3| 3| 5| 7| 3|
| 4| 9| 9| 9| 6| 6| 1| 9| 8| 5| 0| 4| 0| 0| 3| 6| 4| 1| 0| 1| 0| 0| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endothelium, Hyperplasia | |
Myocardium, Degeneration | 1 2 1 2 1 1 2 1 1 2 1|
Myocardium, Degeneration, Multifocal | |
Myocardium, Inflammation, Chronic, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 3 1 |
Hyperplasia, Nodular | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 2 2 2 3 1 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 1 1 2 1 1 2 2 2 1 3 1 2 3 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + M + + + + + + + + + + + M + + + M +|
Inflammation, Chronic | 1 2 1 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Epithelium, Hyperplasia | |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 0| 5| 7| 6| 7| 7| 7| 7| 7| 0| 4| 7| 4| 7| 6| 7| 7| 4| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 7| 9| 7| 2| 9| 1| 3| 0| 3| 3| 9| 5| 0| 5| 3| 7| 3| 3| 5| 7| 3|
| 4| 9| 9| 9| 6| 6| 1| 9| 8| 5| 0| 4| 0| 0| 3| 6| 4| 1| 0| 1| 0| 0| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Femoral, Atrophy | |
Femoral, Hyperplasia, Re Cell | 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Sinus, Ectasia | 3 |
Mediastinal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Infarct | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + M + +|
Hyperplasia, Cystic | 2 1 2 1 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
Femur, Osteopetrosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Hypothalamus, Compression | 4 3 4 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitium, Inflammation, Chronic | 2 |
Peribronchiolar, Inflammation, | |
Chronic, Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 0| 5| 7| 6| 7| 7| 7| 7| 7| 0| 4| 7| 4| 7| 6| 7| 7| 4| 6| 7|
DAY ON TEST | 3| 2| 2| 2| 7| 9| 7| 2| 9| 1| 3| 0| 3| 3| 9| 5| 0| 5| 3| 7| 3| 3| 5| 7| 3|
| 4| 9| 9| 9| 6| 6| 1| 9| 8| 5| 0| 4| 0| 0| 3| 6| 4| 1| 0| 1| 0| 0| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens, Cataract | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
Inflammation, Chronic, Multifocal | 1 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 2 1 2 1 1 1 1 2 2 2|
Nephropathy, Multifocal | 1 |
Renal Tubule, Mineralization, | |
Multifocal | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 0| 4| 6| 4| 0| 7| 7| 7| 7| 7| 5| 0| 7| 7| | |
DAY ON TEST | 3| 3| 5| 3| 7| 3| 9| 5| 8| 5| 9| 3| 3| 3| 3| 3| 5| 9| 3| 3| | |
| 0| 0| 6| 1| 3| 0| 4| 6| 0| 6| 5| 1| 1| 1| 1| 1| 4| 4| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 70 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Angiectasis, Focal | 1 | 1 1.0|
Basophilic Focus | X X X X X X X X X X X | 42 |
Clear Cell Focus | | 3 |
Fatty Change | | 1 4.0|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia, Histiocytic, Lymphoid | | 1 4.0|
Hyperplasia | | 1 2.0|
Inflammation, Granulomatous | 1 1 1 1 2 1 1 | 23 1.0|
Mixed Cell Focus | X | 2 |
Necrosis, Coagulative | | 1 3.0|
Periportal, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | | 3 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | | 1 1.0|
Acinus, Atrophy | 1 1 1 1 | 16 1.3|
Artery, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Acanthosis | | 2 2.0|
Hyperkeratosis | | 2 2.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | | 1 2.0|
Ulcer | | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 0| 4| 6| 4| 0| 7| 7| 7| 7| 7| 5| 0| 7| 7| | |
DAY ON TEST | 3| 3| 5| 3| 7| 3| 9| 5| 8| 5| 9| 3| 3| 3| 3| 3| 5| 9| 3| 3| | |
| 0| 0| 6| 1| 3| 0| 4| 6| 0| 6| 5| 1| 1| 1| 1| 1| 4| 4| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 1 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Endothelium, Hyperplasia | 2 | 1 2.0|
Myocardium, Degeneration | 2 1 3 1 1 2 3 1 1 3 2 2 | 32 1.6|
Myocardium, Degeneration, Multifocal | 1 1 | 3 1.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 1 1 1 2 1 | 13 1.5|
Hyperplasia, Nodular | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | 2 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + + M M + + + + M + + + + + | 61 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Pars Distalis, Angiectasis | 3 | 1 3.0|
Pars Distalis, Cyst | X X | 6 |
Pars Distalis, Hyperplasia | 1 3 3 3 | 12 2.3|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
C-Cell, Hyperplasia | 3 2 1 2 1 1 1 3 2 2 3 2 3 3 | 52 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + | 62 |
Inflammation, Chronic | 1 2 2 2 | 16 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 0| 4| 6| 4| 0| 7| 7| 7| 7| 7| 5| 0| 7| 7| | |
DAY ON TEST | 3| 3| 5| 3| 7| 3| 9| 5| 8| 5| 9| 3| 3| 3| 3| 3| 5| 9| 3| 3| | |
| 0| 0| 6| 1| 3| 0| 4| 6| 0| 6| 5| 1| 1| 1| 1| 1| 4| 4| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | | 1 |
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Cervix, Epithelium, Hyperplasia | | 2 2.5|
Endometrium, Hyperplasia, Cystic | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Femoral, Atrophy | 4 | 1 4.0|
Femoral, Hyperplasia, Re Cell | 1 1 2 | 10 1.4|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 70 |
Inguinal, Sinus, Ectasia | | 1 3.0|
Mediastinal, Sinus, Ectasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + M + + + + + + | 68 |
Infiltration Cellular, Histiocyte | 1 1 1 | 9 2.0|
Sinus, Ectasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 1 3 | 4 2.3|
Hyperplasia, Lymphoid | | 1 1.0|
Infarct | | 2 2.5|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + + + + | 64 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + | 67 |
Hyperplasia, Cystic | 2 2 2 3 1 1 | 17 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Osteopetrosis | | 1 3.0|
Femur, Osteopetrosis | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 7| 0| 4| 6| 4| 0| 7| 7| 7| 7| 7| 5| 0| 7| 7| | |
DAY ON TEST | 3| 3| 5| 3| 7| 3| 9| 5| 8| 5| 9| 3| 3| 3| 3| 3| 5| 9| 3| 3| | |
| 0| 0| 6| 1| 3| 0| 4| 6| 0| 6| 5| 1| 1| 1| 1| 1| 4| 4| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | A |
0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Infarct | | 3 2.7|
Hypothalamus, Compression | 3 3 1 2 | 10 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Interstitium, Inflammation, Chronic | 2 | 3 1.7|
Peribronchiolar, Inflammation, | | |
Chronic, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens, Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + | 8 |
Inflammation, Chronic, Multifocal | 1 1 1 | 7 1.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Nephropathy | 2 2 2 1 1 1 2 2 2 3 2 2 1 | 38 1.4|
Nephropathy, Multifocal | 1 1 1 | 7 1.0|
Renal Tubule, Mineralization, | | |
Multifocal | 1 | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 0| 0| 4| 4| 0| 4| 0| 4| 7| 7| 7| 0| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 1| 6| 2| 3| 0| 0| 9| 9| 5| 7| 9| 5| 9| 5| 2| 2| 2| 9| 1|
| 9| 6| 6| 9| 9| 9| 1| 6| 9| 1| 8| 1| 3| 5| 6| 6| 5| 6| 3| 6| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
150 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
Ulcer | 3|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 |
Basophilic Focus | X X X X X X X X X X X X X X X |
Clear Cell Focus | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | |
Inflammation, Granulomatous | 1 1 1 2 1 |
Mixed Cell Focus | X |
Necrosis, Coagulative | 3 1 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + +|
Cyst | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + +|
Ulcer | 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Atrium, Thrombosis | X |
Myocardium, Degeneration | 1 2 1 1 2 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 1 4 1 1|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 0| 0| 4| 4| 0| 4| 0| 4| 7| 7| 7| 0| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 1| 6| 2| 3| 0| 0| 9| 9| 5| 7| 9| 5| 9| 5| 2| 2| 2| 9| 1|
| 9| 6| 6| 9| 9| 9| 1| 6| 9| 1| 8| 1| 3| 5| 6| 6| 5| 6| 3| 6| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
150 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + +|
Hyperplasia | 2 4|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 4 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 1 2 3 2 3 2 2 1|
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Vagina | + |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 2 2 1 2 2 3 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 0| 0| 4| 4| 0| 4| 0| 4| 7| 7| 7| 0| 7|
DAY ON TEST | 2| 5| 5| 2| 2| 2| 1| 6| 2| 3| 0| 0| 9| 9| 5| 7| 9| 5| 9| 5| 2| 2| 2| 9| 1|
| 9| 6| 6| 9| 9| 9| 1| 6| 9| 1| 8| 1| 3| 5| 6| 6| 5| 6| 3| 6| 9| 9| 9| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
150 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + +|
Infarct | |
Hypothalamus, Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + +|
Alveolus, Inflammation, Subacute | 3 3 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + +|
Nares, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 1 3 1 1 1 1 1 1 1 1 2 1 1|
Nephropathy, Multifocal | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 9| 1| 2| 3| 1| 3| 5| 6| 3| 5| 3| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3| 5|
| 9| 9| 9| 2| 5| 9| 0| 5| 1| 6| 2| 0| 6| 0| 0| 0| 0| 6| 0| 6| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
150 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + + A + + + + + + + + + + + + + |
Ulcer | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 3 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 2 2 |
Inflammation, Granulomatous | 1 1 1 1 2 2 1 1|
Mixed Cell Focus | X |
Necrosis, Coagulative | |
Vacuolization Cytoplasmic, Focal | 1 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 1 1 1 2 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Atrium, Thrombosis | X |
Myocardium, Degeneration | 2 2 1 1 1 2 1 1 1 2 1 2 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 9| 1| 2| 3| 1| 3| 5| 6| 3| 5| 3| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3| 5|
| 9| 9| 9| 2| 5| 9| 0| 5| 1| 6| 2| 0| 6| 0| 0| 0| 0| 6| 0| 6| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
150 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 3 2 2 3 3 1 1 2 2 1 2 |
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 2 1 1 1 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Dilatation | 3 |
Endometrium, Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | |
Infiltration Cellular, | |
Polymorphonuclear | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | 2 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + M + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Infarct | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + M + + + + + M + M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Cystic | 3 2 2 1 4 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 2| 2| 2| 9| 1| 2| 3| 1| 3| 5| 6| 3| 5| 3| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3| 5|
| 9| 9| 9| 2| 5| 9| 0| 5| 1| 6| 2| 0| 6| 0| 0| 0| 0| 6| 0| 6| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
150 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
Osteopetrosis | 3 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Infarct | 3 |
Hypothalamus, Compression | 4 1 2 3 4 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Alveolus, Inflammation, Subacute | |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Nares, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 3 |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 2 1 1 1 1 2 2 2 2 1 1 2 1 1 2 1 |
Nephropathy, Multifocal | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 0| 7| 7| 0| 6| 7| 7| 5| 7| 0| 7| 6| 7| 7| 0| 7| 0| | |
DAY ON TEST | 5| 0| 3| 9| 3| 3| 9| 4| 3| 3| 2| 0| 9| 3| 0| 3| 3| 9| 3| 9| | |
| 6| 8| 1| 3| 1| 1| 4| 3| 1| 1| 2| 0| 5| 1| 0| 1| 1| 3| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
150 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 47 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 50 |
Parasite Metazoan | | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 50 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 61 |
Angiectasis, Focal | | 5 2.0|
Basophilic Focus | X X X X X X X X X X X | 45 |
Clear Cell Focus | X X X | 3 |
Hepatodiaphragmatic Nodule | X | 7 |
Hyperplasia | 2 | 3 2.0|
Inflammation, Granulomatous | 1 1 | 15 1.2|
Mixed Cell Focus | | 2 |
Necrosis, Coagulative | | 2 2.0|
Vacuolization Cytoplasmic, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + | 50 |
Acinus, Atrophy | 1 1 | 6 1.2|
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 50 |
Cyst | X | 1 |
Ulcer | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 50 |
Ulcer | 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 50 |
Atrium, Thrombosis | | 2 |
Myocardium, Degeneration | 2 2 1 2 2 2 1 1 2 | 39 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 0| 7| 7| 0| 6| 7| 7| 5| 7| 0| 7| 6| 7| 7| 0| 7| 0| | |
DAY ON TEST | 5| 0| 3| 9| 3| 3| 9| 4| 3| 3| 2| 0| 9| 3| 0| 3| 3| 9| 3| 9| | |
| 6| 8| 1| 3| 1| 1| 4| 3| 1| 1| 2| 0| 5| 1| 0| 1| 1| 3| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
150 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + | 50 |
Hyperplasia | 1 1 | 18 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + | 50 |
Hyperplasia | 1 2 1 | 6 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + | 53 |
Pars Distalis, Angiectasis | | 3 2.7|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 1 2 2 2 | 12 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 2 2 1 2 2 1 1 2 2 2 | 32 1.9|
Follicle, Dilatation | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + | 49 |
Inflammation, Chronic | 2 1 1 1 2 1 | 17 1.4|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + | 50 |
Cyst | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + | 51 |
Dilatation | 2 | 2 2.5|
Endometrium, Hyperplasia, Cystic | 2 | 2 1.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + | 51 |
Hyperplasia, Plasma Cell | | 2 2.0|
Sinus, Ectasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 0| 7| 7| 0| 6| 7| 7| 5| 7| 0| 7| 6| 7| 7| 0| 7| 0| | |
DAY ON TEST | 5| 0| 3| 9| 3| 3| 9| 4| 3| 3| 2| 0| 9| 3| 0| 3| 3| 9| 3| 9| | |
| 6| 8| 1| 3| 1| 1| 4| 3| 1| 1| 2| 0| 5| 1| 0| 1| 1| 3| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
150 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 50 |
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + | 49 |
Hyperplasia, Cystic | 2 2 1 3 2 3 2 1 3 | 25 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 50 |
Osteopetrosis | 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 50 |
Infarct | 3 | 2 3.0|
Hypothalamus, Compression | | 7 2.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 50 |
Alveolus, Inflammation, Subacute | | 2 3.0|
Interstitium, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + | 50 |
Nares, Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Lens, Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 60 |
Nephropathy | 1 1 1 1 1 2 2 1 1 1 2 1 | 45 1.3|
Nephropathy, Multifocal | 2 | 8 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 0| 4| 7| 7| 6| 7| 4| 7| 6| 7| 7| 0| 6| 7| 7| 3| 4| 7| 4| 0|
DAY ON TEST | 2| 5| 2| 5| 3| 9| 5| 0| 2| 1| 2| 5| 2| 6| 2| 2| 9| 5| 2| 2| 9| 5| 2| 5| 9|
| 9| 6| 9| 6| 1| 6| 6| 7| 9| 9| 9| 6| 9| 2| 9| 9| 6| 2| 9| 9| 7| 6| 9| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
300 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + |
Basophilic Focus | X X X X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | |
Hyperplasia | 2 |
Inflammation, Granulomatous | 1 1 1 1 1 1 1 1 1 2 |
Mixed Cell Focus | X X X X X |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Acinus, Atrophy | 1 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Ulcer | |
Mucosa, Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
Acanthosis | |
Hyperkeratosis | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Myocardium, Degeneration | 2 2 1 1 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 0| 4| 7| 7| 6| 7| 4| 7| 6| 7| 7| 0| 6| 7| 7| 3| 4| 7| 4| 0|
DAY ON TEST | 2| 5| 2| 5| 3| 9| 5| 0| 2| 1| 2| 5| 2| 6| 2| 2| 9| 5| 2| 2| 9| 5| 2| 5| 9|
| 9| 6| 9| 6| 1| 6| 6| 7| 9| 9| 9| 6| 9| 2| 9| 9| 6| 2| 9| 9| 7| 6| 9| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
300 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + |
Hyperplasia | 3 1 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Necrosis, Liquifactive | |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 3 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 3 1 2 1 2 2 2 2 |
Follicle, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 1 2 1 1 1 1 1 2 1 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + |
Cyst | |
Follicle, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + |
Dilatation | |
Hemorrhage | 3 |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + |
Mediastinal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + |
Hyperplasia, Plasma Cell | 2 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Depletion Lymphoid | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 0| 4| 7| 7| 6| 7| 4| 7| 6| 7| 7| 0| 6| 7| 7| 3| 4| 7| 4| 0|
DAY ON TEST | 2| 5| 2| 5| 3| 9| 5| 0| 2| 1| 2| 5| 2| 6| 2| 2| 9| 5| 2| 2| 9| 5| 2| 5| 9|
| 9| 6| 9| 6| 1| 6| 6| 7| 9| 9| 9| 6| 9| 2| 9| 9| 6| 2| 9| 9| 7| 6| 9| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
300 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Cystic | 3 1 2 3 1 1 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Infarct | |
Hypothalamus, Compression | 4 4 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + |
Foreign Body | 2 |
Inflammation, Granulomatous | 1 1 |
Alveolus, Inflammation, Subacute | |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Hemorrhage | |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Nephropathy | 1 2 2 1 2 1 2 2 1 1 1 1 1 2 1 |
Nephropathy, Multifocal | 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 0| 7| 7| 6| 7| 4| 7| 0| 6| 7| 0| 6| 3| 0| 7| 7| 7| 7| 4| 7| 0| 7|
DAY ON TEST | 2| 3| 5| 9| 2| 3| 2| 3| 5| 3| 9| 9| 3| 9| 8| 8| 9| 3| 3| 3| 3| 5| 0| 9| 3|
| 3| 5| 6| 3| 9| 0| 8| 0| 6| 0| 5| 6| 0| 4| 2| 3| 4| 0| 0| 0| 0| 6| 4| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | |
Hyperplasia | 2 2 |
Inflammation, Granulomatous | 1 1 1 2 2 1 1 2 |
Mixed Cell Focus | X X |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + +|
Ulcer | 2 2 |
Mucosa, Mineralization | 1 |
__________________________________________________________________________|
Tongue | |
Acanthosis | |
Hyperkeratosis | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 2 2 1 1 2 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 0| 7| 7| 6| 7| 4| 7| 0| 6| 7| 0| 6| 3| 0| 7| 7| 7| 7| 4| 7| 0| 7|
DAY ON TEST | 2| 3| 5| 9| 2| 3| 2| 3| 5| 3| 9| 9| 3| 9| 8| 8| 9| 3| 3| 3| 3| 5| 0| 9| 3|
| 3| 5| 6| 3| 9| 0| 8| 0| 6| 0| 5| 6| 0| 4| 2| 3| 4| 0| 0| 0| 0| 6| 4| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Necrosis, Liquifactive | 2 |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 1 3 2 3 2 3 2 2 2 |
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 2 1 2 1 2 2 3 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + +|
Cyst | X |
Follicle, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hemorrhage | |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Mediastinal, Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + +|
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Inflammation, Granulomatous | 1 3 |
__________________________________________________________________________|
Thymus | + + M M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 6| 4| 0| 7| 7| 6| 7| 4| 7| 0| 6| 7| 0| 6| 3| 0| 7| 7| 7| 7| 4| 7| 0| 7|
DAY ON TEST | 2| 3| 5| 9| 2| 3| 2| 3| 5| 3| 9| 9| 3| 9| 8| 8| 9| 3| 3| 3| 3| 5| 0| 9| 3|
| 3| 5| 6| 3| 9| 0| 8| 0| 6| 0| 5| 6| 0| 4| 2| 3| 4| 0| 0| 0| 0| 6| 4| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
300 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia, Cystic | 3 2 3 4 1 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Hypothalamus, Compression | 4 2 1 3 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Granulomatous | |
Alveolus, Inflammation, Subacute | |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Hemorrhage | |
Lens, Cataract | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 2 1 2 1 2 1 1 1 1 2 1 1 3|
Nephropathy, Multifocal | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 0| 7| 7| 4| 0| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 8| 3| 7| 3| 3| 3| 3| 3| | |
| 0| 0| 9| 6| 1| 1| 6| 3| 1| 1| 1| 0| 9| 1| 8| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
300 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 50 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 61 |
Basophilic Focus | X X X X X X X X X X X X | 37 |
Clear Cell Focus | X | 4 |
Eosinophilic Focus | X | 1 |
Fatty Change | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia | | 3 2.0|
Inflammation, Granulomatous | 2 1 1 1 | 22 1.2|
Mixed Cell Focus | X X | 9 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 50 |
Acinus, Atrophy | 1 1 1 1 | 11 1.1|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 50 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 50 |
Ulcer | 2 | 3 2.0|
Mucosa, Mineralization | | 2 1.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
Acanthosis | 2 | 1 2.0|
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + | 2 |
Peridontal Tissue, Inflammation, | | |
Chronic | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 0| 7| 7| 4| 0| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 8| 3| 7| 3| 3| 3| 3| 3| | |
| 0| 0| 9| 6| 1| 1| 6| 3| 1| 1| 1| 0| 9| 1| 8| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
300 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 50 |
Myocardium, Degeneration | 2 1 2 2 1 1 2 1 1 2 2 | 30 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia | 3 1 | 10 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 52 |
Necrosis, Liquifactive | | 1 2.0|
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Cyst | X | 4 |
Pars Distalis, Hyperplasia | 3 2 3 | 9 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 3 2 3 2 2 2 2 2 2 2 3 2 2 3 | 37 2.1|
Follicle, Dilatation | | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic | 1 1 2 2 1 1 | 28 1.4|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + | 50 |
Cyst | | 1 |
Follicle, Cyst | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 50 |
Dilatation | | 1 2.0|
Hemorrhage | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 50 |
Mediastinal, Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + | 49 |
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 0| 7| 7| 4| 0| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 8| 3| 7| 3| 3| 3| 3| 3| | |
| 0| 0| 9| 6| 1| 1| 6| 3| 1| 1| 1| 0| 9| 1| 8| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
300 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Sinus, Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 50 |
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 50 |
Depletion Lymphoid | 3 | 1 3.0|
Inflammation, Granulomatous | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + M | 49 |
Hyperplasia, Cystic | 3 1 2 3 2 3 1 1 4 | 22 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 50 |
Osteopetrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 50 |
Infarct | | 1 2.0|
Hypothalamus, Compression | 2 2 4 1 4 | 11 2.8|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 50 |
Foreign Body | | 1 2.0|
Inflammation, Granulomatous | | 2 1.0|
Alveolus, Inflammation, Subacute | 2 | 1 2.0|
Interstitium, Inflammation, Chronic | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Hemorrhage | 3 | 1 3.0|
Lens, Cataract | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 0| 7| 7| 4| 0| 7| 7| 7| 6| 6| 7| 3| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 5| 9| 3| 3| 3| 8| 8| 3| 7| 3| 3| 3| 3| 3| | |
| 0| 0| 9| 6| 1| 1| 6| 3| 1| 1| 1| 0| 9| 1| 8| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
300 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + | 60 |
Cyst | | 1 |
Nephropathy | 3 1 1 1 1 1 1 1 1 3 2 1 1 1 2 1 | 45 1.4|
Nephropathy, Multifocal | 1 | 5 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 6| 6| 4| 0| 0| 7| 4| 7| 7| 4| 4| 5| 7| 4| 0| 4| 0| 6| 0| 7| 6| 7| 7| 6| 6|
DAY ON TEST | 8| 1| 5| 9| 9| 2| 5| 2| 2| 5| 5| 0| 0| 5| 9| 5| 9| 2| 9| 2| 9| 2| 2| 4| 4|
| 5| 9| 6| 4| 5| 9| 6| 9| 9| 6| 6| 9| 9| 6| 6| 6| 5| 0| 4| 9| 8| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X|
Clear Cell Focus | X X|
Degeneration, Cystic | |
Eosinophilic Focus | |
Fatty Change | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 2 |
Inflammation, Granulomatous | 1 3 1 1 |
Mixed Cell Focus | X X X |
Necrosis, Coagulative | |
Periportal, Inflammation, Chronic | 1 |
Serosa, Hemorrhage | 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | 4 1 |
Epithelium, Acanthosis, Diffuse | |
Epithelium, Hyperkeratosis, Diffuse | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 1 1 3 2 1 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 6| 6| 4| 0| 0| 7| 4| 7| 7| 4| 4| 5| 7| 4| 0| 4| 0| 6| 0| 7| 6| 7| 7| 6| 6|
DAY ON TEST | 8| 1| 5| 9| 9| 2| 5| 2| 2| 5| 5| 0| 0| 5| 9| 5| 9| 2| 9| 2| 9| 2| 2| 4| 4|
| 5| 9| 6| 4| 5| 9| 6| 9| 9| 6| 6| 9| 9| 6| 6| 6| 5| 0| 4| 9| 8| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Degeneration, Multifocal | 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + M + + + + + + + + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Degeneration, Cystic | 1 |
Pars Distalis, Hyperplasia | 3 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 2 2 1 1 2 3 1 1 1 1 2 |
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Inflammation, Chronic | 1 3 2 2 1 2 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Re Cell | 1 1 1 1 2 |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Sinus, Ectasia | |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
Pancreatic, Hyperplasia, Plasma Cell | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 3 2 1 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 6| 6| 4| 0| 0| 7| 4| 7| 7| 4| 4| 5| 7| 4| 0| 4| 0| 6| 0| 7| 6| 7| 7| 6| 6|
DAY ON TEST | 8| 1| 5| 9| 9| 2| 5| 2| 2| 5| 5| 0| 0| 5| 9| 5| 9| 2| 9| 2| 9| 2| 2| 4| 4|
| 5| 9| 6| 4| 5| 9| 6| 9| 9| 6| 6| 9| 9| 6| 6| 6| 5| 0| 4| 9| 8| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sinus, Ectasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + M M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 2 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | 4 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Foreign Body | |
Alveolus, Inflammation, Subacute | |
Interstitium, Inflammation, Chronic | |
Peribronchiolar, Inflammation, | |
Chronic Active, Multifocal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nares, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Focal | 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 |
Nephropathy | 2 1 2 1 2 1 1 1 3 1 2 |
Nephropathy, Multifocal | 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 6| 6| 4| 0| 0| 7| 4| 7| 7| 4| 4| 5| 7| 4| 0| 4| 0| 6| 0| 7| 6| 7| 7| 6| 6|
DAY ON TEST | 8| 1| 5| 9| 9| 2| 5| 2| 2| 5| 5| 0| 0| 5| 9| 5| 9| 2| 9| 2| 9| 2| 2| 4| 4|
| 5| 9| 6| 4| 5| 9| 6| 9| 9| 6| 6| 9| 9| 6| 6| 6| 5| 0| 4| 9| 8| 9| 9| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 0| 7|
DAY ON TEST | 3| 3| 0| 2| 1| 2| 3| 2| 4| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 5| 9| 3|
| 0| 0| 7| 9| 5| 9| 1| 9| 2| 0| 1| 8| 0| 0| 9| 0| 0| 0| 0| 1| 0| 7| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X|
Degeneration, Cystic | 1 |
Eosinophilic Focus | X X X |
Fatty Change | 3 2 2 |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia | 1 |
Inflammation, Granulomatous | 1 1 1|
Mixed Cell Focus | X X X X X X |
Necrosis, Coagulative | |
Periportal, Inflammation, Chronic | |
Serosa, Hemorrhage | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ulcer | 4 |
Epithelium, Acanthosis, Diffuse | |
Epithelium, Hyperkeratosis, Diffuse | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 2 1 2 1 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 0| 7|
DAY ON TEST | 3| 3| 0| 2| 1| 2| 3| 2| 4| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 5| 9| 3|
| 0| 0| 7| 9| 5| 9| 1| 9| 2| 0| 1| 8| 0| 0| 9| 0| 0| 0| 0| 1| 0| 7| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Myocardium, Degeneration, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 4 2 1 2 2 1 3 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X|
Pars Distalis, Degeneration, Cystic | |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 3 2 1 2 1 2 2 1 1 4 2 4 3 1 2|
Follicle, Dilatation | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic | 1 2 1 1 2 1 1 1 1|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femoral, Hyperplasia, Re Cell | 2 |
Femoral, Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumbar, Sinus, Ectasia | |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
Pancreatic, Hyperplasia, Plasma Cell | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Ectasia | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 0| 7|
DAY ON TEST | 3| 3| 0| 2| 1| 2| 3| 2| 4| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 5| 9| 3|
| 0| 0| 7| 9| 5| 9| 1| 9| 2| 0| 1| 8| 0| 0| 9| 0| 0| 0| 0| 1| 0| 7| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Sinus, Ectasia | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 1 3 2 2 2 2 2 2 3 2 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | 4 2 2 4 4 3 4 3 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Foreign Body | 2 |
Alveolus, Inflammation, Subacute | |
Interstitium, Inflammation, Chronic | 1 1 |
Peribronchiolar, Inflammation, | |
Chronic Active, Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nares, Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Focal | 1 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Nephropathy | 3 2 2 2 1 2 2 3 1 1 3 1 2 2 1 2 2 1 1 2 2 2|
Nephropathy, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 4| 0| 7|
DAY ON TEST | 3| 3| 0| 2| 1| 2| 3| 2| 4| 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 5| 9| 3|
| 0| 0| 7| 9| 5| 9| 1| 9| 2| 0| 1| 8| 0| 0| 9| 0| 0| 0| 0| 1| 0| 7| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
600 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 4| 0| 0| 4| 7| 0| 5| 7| 7| 4| 4| 0| 6| 7| 6| 7| 7| | |
DAY ON TEST | 2| 3| 3| 5| 9| 9| 6| 0| 9| 4| 3| 3| 5| 5| 9| 3| 3| 9| 3| 3| | |
| 0| 0| 1| 6| 3| 5| 6| 7| 3| 1| 1| 1| 6| 6| 3| 4| 1| 5| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 69 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + | 69 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Basophilic Focus | X X X X X X X X X | 38 |
Clear Cell Focus | X X X | 9 |
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | | 3 |
Fatty Change | | 3 2.3|
Hepatodiaphragmatic Nodule | X | 7 |
Hyperplasia | | 2 1.5|
Inflammation, Granulomatous | 2 1 1 1 1 1 1 | 14 1.2|
Mixed Cell Focus | X X X X | 13 |
Necrosis, Coagulative | 1 | 1 1.0|
Periportal, Inflammation, Chronic | | 1 1.0|
Serosa, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Acinus, Atrophy | 1 1 1 1 1 1 | 15 1.1|
Artery, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | 3 | 2 2.5|
Ulcer | | 3 3.0|
Epithelium, Acanthosis, Diffuse | 2 | 1 2.0|
Epithelium, Hyperkeratosis, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | | 1 2.0|
Ulcer | 1 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 4| 0| 0| 4| 7| 0| 5| 7| 7| 4| 4| 0| 6| 7| 6| 7| 7| | |
DAY ON TEST | 2| 3| 3| 5| 9| 9| 6| 0| 9| 4| 3| 3| 5| 5| 9| 3| 3| 9| 3| 3| | |
| 0| 0| 1| 6| 3| 5| 6| 7| 3| 1| 1| 1| 6| 6| 3| 4| 1| 5| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Myocardium, Degeneration | 2 1 2 1 2 1 1 2 | 27 1.4|
Myocardium, Degeneration, Multifocal | | 3 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 1 2 2 1 | 16 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 1 | 5 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 65 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Pars Distalis, Cyst | X X | 6 |
Pars Distalis, Degeneration, Cystic | | 1 1.0|
Pars Distalis, Hyperplasia | 3 3 1 4 1 2 | 14 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
C-Cell, Hyperplasia | 2 2 1 2 3 2 4 1 1 1 1 2 | 43 1.8|
Follicle, Dilatation | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + I + + + + + + + + + + + + + + + | 67 |
Inflammation, Chronic | 2 2 1 1 1 1 | 22 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | X X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + | 70 |
Dilatation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Femoral, Hyperplasia, Re Cell | 1 1 2 | 9 1.3|
Femoral, Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 4| 0| 0| 4| 7| 0| 5| 7| 7| 4| 4| 0| 6| 7| 6| 7| 7| | |
DAY ON TEST | 2| 3| 3| 5| 9| 9| 6| 0| 9| 4| 3| 3| 5| 5| 9| 3| 3| 9| 3| 3| | |
| 0| 0| 1| 6| 3| 5| 6| 7| 3| 1| 1| 1| 6| 6| 3| 4| 1| 5| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Sinus, Ectasia | 2 | 1 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Pancreatic, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 |
Sinus, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + M + + + + | 68 |
Infiltration Cellular, Histiocyte | 2 1 3 3 | 10 2.2|
Sinus, Ectasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Hematopoietic Cell Proliferation | 3 | 3 2.7|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + + + + + + | 65 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + + + + + + + + + + + + + + + + | 66 |
Hyperplasia, Cystic | 3 1 3 2 1 1 2 2 | 24 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 70 |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Femur, Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Hypothalamus, Compression | 1 4 2 | 14 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Abscess | | 1 2.0|
Foreign Body | | 1 2.0|
Alveolus, Inflammation, Subacute | 2 | 1 2.0|
Interstitium, Inflammation, Chronic | | 2 1.0|
Peribronchiolar, Inflammation, | | |
Chronic Active, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Nares, Inflammation, Suppurative | 3 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 4| 0| 0| 4| 7| 0| 5| 7| 7| 4| 4| 0| 6| 7| 6| 7| 7| | |
DAY ON TEST | 2| 3| 3| 5| 9| 9| 6| 0| 9| 4| 3| 3| 5| 5| 9| 3| 3| 9| 3| 3| | |
| 0| 0| 1| 6| 3| 5| 6| 7| 3| 1| 1| 1| 6| 6| 3| 4| 1| 5| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
600 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Lens, Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Inflammation, Chronic, Focal | | 2 1.0|
Inflammation, Suppurative | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Hydronephrosis | | 1 2.0|
Nephropathy | 2 1 1 1 1 1 2 1 1 1 1 2 | 45 1.6|
Nephropathy, Multifocal | 2 2 2 | 8 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + | 70 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 6| 0| 6| 6| 7| 4| 4| 0| 6| 4| 7| 7| 5| 3| 7| 5| 7| 0| 0| 4| 6| 7| 0| 7|
DAY ON TEST | 3| 8| 9| 5| 4| 1| 5| 5| 9| 2| 5| 0| 3| 8| 3| 2| 3| 1| 9| 9| 8| 5| 2| 9| 3|
| 0| 1| 4| 9| 5| 9| 6| 6| 6| 4| 6| 2| 0| 4| 6| 6| 9| 4| 6| 3| 8| 3| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Edema | 4 |
Mineralization | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Basophilic Focus | X X X |
Clear Cell Focus | X|
Degeneration, Cystic | 1 2 1 |
Eosinophilic Focus | |
Inflammation, Granulomatous | 1 |
Necrosis, Coagulative | 3 |
Periportal, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 2 |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 |
Artery, Inflammation, Chronic | 2 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Focal, Subacute | 2 |
Mineralization | 2 |
Ulcer | 3 |
Epithelium, Acanthosis, Focal | 2 |
Epithelium, Hyperkeratosis, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 |
Inflammation, Focal, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 6| 0| 6| 6| 7| 4| 4| 0| 6| 4| 7| 7| 5| 3| 7| 5| 7| 0| 0| 4| 6| 7| 0| 7|
DAY ON TEST | 3| 8| 9| 5| 4| 1| 5| 5| 9| 2| 5| 0| 3| 8| 3| 2| 3| 1| 9| 9| 8| 5| 2| 9| 3|
| 0| 1| 4| 9| 5| 9| 6| 6| 6| 4| 6| 2| 0| 4| 6| 6| 9| 4| 6| 3| 8| 3| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 1 1 3 |
Mucosa, Hyperplasia, Focal | 2 |
Mucosa, Mineralization | 3 1 1 |
__________________________________________________________________________|
Tongue | |
Acanthosis | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Dilatation | |
Atrium, Thrombosis | |
Myocardium, Degeneration | 2 1 3 2 3 3 3 2 1 3 2|
Myocardium, Degeneration, Multifocal | 1 1 |
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 1 2 1 2 |
Myocardium, Inflammation, Suppurative| 2 |
Myocardium, Mineralization | 2 |
Valve, Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 1 1 |
Hyperplasia, Nodular | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
Infarct | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M M + + + + + + + + M + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 1 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 1 1 1 1 2 2 1 2 4 1 3|
Follicle, Dilatation | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 6| 0| 6| 6| 7| 4| 4| 0| 6| 4| 7| 7| 5| 3| 7| 5| 7| 0| 0| 4| 6| 7| 0| 7|
DAY ON TEST | 3| 8| 9| 5| 4| 1| 5| 5| 9| 2| 5| 0| 3| 8| 3| 2| 3| 1| 9| 9| 8| 5| 2| 9| 3|
| 0| 1| 4| 9| 5| 9| 6| 6| 6| 4| 6| 2| 0| 4| 6| 6| 9| 4| 6| 3| 8| 3| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 3 2 2 1 2 2 1 2 1 2 3 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
Inflammation, Suppurative | 2 1 2 2 4 1 1 3 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | 4 |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 4 4 4 |
Seminiferous Tubule, Hypoplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 2 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 3 |
Infarct | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + M + + M + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + M + + + + M + + + M M + M + +|
Hyperplasia, Cystic | 1 2 1 3 1 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | X |
Synovial Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 6| 0| 6| 6| 7| 4| 4| 0| 6| 4| 7| 7| 5| 3| 7| 5| 7| 0| 0| 4| 6| 7| 0| 7|
DAY ON TEST | 3| 8| 9| 5| 4| 1| 5| 5| 9| 2| 5| 0| 3| 8| 3| 2| 3| 1| 9| 9| 8| 5| 2| 9| 3|
| 0| 1| 4| 9| 5| 9| 6| 6| 6| 4| 6| 2| 0| 4| 6| 6| 9| 4| 6| 3| 8| 3| 9| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 4 |
Infarct | 3 2 |
Hypothalamus, Compression | 4 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchus, Foreign Body, Single | 1 |
Bronchus, Epithelium, Hyperplasia, | |
Multifocal | 1 |
Interstitium, Inflammation, Chronic | |
Interstitium, Mineralization | 2 |
Peribronchiolar, Inflammation, | |
Chronic, Multifocal | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Nares, Inflammation, Suppurative | 2 |
Sinus, Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Abscess | |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | |
Cornea, Mineralization | 2 |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 1 |
Inflammation, Suppurative | 3 |
Nephropathy | 4 3 3 4 3 3 2 3 2 1 3 2 2 2 2 2 2|
Nephropathy, Multifocal | 1 1 1 |
Interstitial Tissue, Inflammation, | |
Chronic, Multifocal | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
Inflammation, Suppurative | |
Lumen, Hemorrhage | 2 1 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 0| 7| 0| 7| 4| 7| 0| 7| 7| 7| 0| 7| 0| 0| 0| 4| 4| 7| 7| 6| 0|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 9| 3| 5| 2| 9| 2| 3| 3| 9| 3| 8| 8| 8| 5| 5| 2| 2| 7| 9|
| 0| 4| 0| 0| 6| 0| 4| 0| 6| 9| 3| 9| 1| 1| 5| 1| 3| 3| 3| 6| 6| 9| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Mineralization | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Basophilic Focus | X X X X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1 1 1 2 |
Eosinophilic Focus | X |
Inflammation, Granulomatous | 1 1 1 |
Necrosis, Coagulative | 1 |
Periportal, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 1 1 |
Artery, Inflammation, Chronic | 2 2 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Inflammation, Focal, Subacute | |
Mineralization | 2 |
Ulcer | 4 |
Epithelium, Acanthosis, Focal | 2 |
Epithelium, Hyperkeratosis, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
Inflammation, Focal, Subacute | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 0| 7| 0| 7| 4| 7| 0| 7| 7| 7| 0| 7| 0| 0| 0| 4| 4| 7| 7| 6| 0|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 9| 3| 5| 2| 9| 2| 3| 3| 9| 3| 8| 8| 8| 5| 5| 2| 2| 7| 9|
| 0| 4| 0| 0| 6| 0| 4| 0| 6| 9| 3| 9| 1| 1| 5| 1| 3| 3| 3| 6| 6| 9| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
Mucosa, Hyperplasia, Focal | |
Mucosa, Mineralization | 2 3 2 |
__________________________________________________________________________|
Tongue | + |
Acanthosis | 3 |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Dilatation | 4 |
Atrium, Thrombosis | X |
Myocardium, Degeneration | 3 2 2 3 2 3 2 1 1 1 1 2 1 |
Myocardium, Degeneration, Multifocal | 1 |
Myocardium, Inflammation, Chronic, | |
Multifocal | 2 1 1 1 |
Myocardium, Inflammation, Suppurative| |
Myocardium, Mineralization | 3 |
Valve, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 2 |
Hyperplasia, Nodular | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 1 1 1 |
Infarct | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 3 1 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 2 2 3 1 4 2 2 3 1 2 2 1 |
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 0| 7| 0| 7| 4| 7| 0| 7| 7| 7| 0| 7| 0| 0| 0| 4| 4| 7| 7| 6| 0|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 9| 3| 5| 2| 9| 2| 3| 3| 9| 3| 8| 8| 8| 5| 5| 2| 2| 7| 9|
| 0| 4| 0| 0| 6| 0| 4| 0| 6| 9| 3| 9| 1| 1| 5| 1| 3| 3| 3| 6| 6| 9| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 2 1 2 1 2 1 2 2 1 2 2 2 |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Coagulative | |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 |
Seminiferous Tubule, Hypoplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 2 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Infarct | |
__________________________________________________________________________|
Thymus | M + + M + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + + M + + + + + + + M + M + + + + + + M|
Hyperplasia, Cystic | 4 4 2 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + M + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | X X |
Synovial Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 0| 7| 0| 7| 4| 7| 0| 7| 7| 7| 0| 7| 0| 0| 0| 4| 4| 7| 7| 6| 0|
DAY ON TEST | 3| 8| 3| 3| 9| 3| 9| 3| 5| 2| 9| 2| 3| 3| 9| 3| 8| 8| 8| 5| 5| 2| 2| 7| 9|
| 0| 4| 0| 0| 6| 0| 4| 0| 6| 9| 3| 9| 1| 1| 5| 1| 3| 3| 3| 6| 6| 9| 9| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Infarct | |
Hypothalamus, Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchus, Foreign Body, Single | |
Bronchus, Epithelium, Hyperplasia, | |
Multifocal | |
Interstitium, Inflammation, Chronic | 2 |
Interstitium, Mineralization | 2 |
Peribronchiolar, Inflammation, | |
Chronic, Multifocal | 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Nares, Inflammation, Suppurative | |
Sinus, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Abscess | 4 |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
Cornea, Mineralization | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | |
Inflammation, Suppurative | |
Nephropathy | 4 1 2 2 3 2 4 4 3 4 4 3 4 3 |
Nephropathy, Multifocal | 1 1 1 |
Interstitial Tissue, Inflammation, | |
Chronic, Multifocal | 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
Inflammation, Suppurative | |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 4| 7| 7| 5| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 2| 5| 3| 3| 5| 3| 5| 3| 7| 5| 0| 2| 0| 3| 2| 2| 1| 5| | |
| 0| 1| 5| 6| 1| 1| 6| 1| 6| 1| 0| 6| 9| 9| 8| 1| 9| 9| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + | 70 |
Mineralization | | 1 2.0|
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + | 69 |
Edema | | 1 4.0|
Mineralization | | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + | 69 |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + | 70 |
Bacterium | | 1 |
Basophilic Focus | X X X X X X X | 16 |
Clear Cell Focus | X | 4 |
Degeneration, Cystic | 1 1 1 | 10 1.2|
Eosinophilic Focus | X | 2 |
Inflammation, Granulomatous | 1 1 1 | 7 1.0|
Necrosis, Coagulative | | 2 2.0|
Periportal, Inflammation, Chronic | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis | 3 | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + | 70 |
Acinus, Atrophy | 2 1 1 1 1 1 1 2 2 1 | 16 1.3|
Artery, Inflammation, Chronic | 1 2 1 4 1 2 | 14 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Focal, Subacute | | 1 2.0|
Mineralization | | 2 2.0|
Ulcer | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 4| 7| 7| 5| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 2| 5| 3| 3| 5| 3| 5| 3| 7| 5| 0| 2| 0| 3| 2| 2| 1| 5| | |
| 0| 1| 5| 6| 1| 1| 6| 1| 6| 1| 0| 6| 9| 9| 8| 1| 9| 9| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Acanthosis, Focal | | 2 2.0|
Epithelium, Hyperkeratosis, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | | 4 1.5|
Inflammation, Focal, Subacute | | 1 2.0|
Ulcer | 2 2 2 2 | 8 2.0|
Mucosa, Hyperplasia, Focal | | 1 2.0|
Mucosa, Mineralization | 3 | 7 2.1|
__________________________________________________________________________|____________|
Tongue | | 1 |
Acanthosis | | 1 3.0|
Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Atrium, Dilatation | | 1 4.0|
Atrium, Thrombosis | | 1 |
Myocardium, Degeneration | 3 2 2 2 3 3 2 2 1 1 | 34 2.1|
Myocardium, Degeneration, Multifocal | 2 1 1 | 6 1.2|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 9 1.3|
Myocardium, Inflammation, Suppurative| | 1 2.0|
Myocardium, Mineralization | | 2 2.5|
Valve, Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia | 1 1 1 | 8 1.4|
Hyperplasia, Nodular | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 1 1 2 3 | 12 1.9|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + M + + + + + + + + + + + | 64 |
Hyperplasia | 4 | 4 3.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 4| 7| 7| 5| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 2| 5| 3| 3| 5| 3| 5| 3| 7| 5| 0| 2| 0| 3| 2| 2| 1| 5| | |
| 0| 1| 5| 6| 1| 1| 6| 1| 6| 1| 0| 6| 9| 9| 8| 1| 9| 9| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia | 2 | 10 1.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
C-Cell, Hyperplasia | 2 1 1 2 2 1 3 1 2 2 1 1 2 3 3 1 1 | 43 1.9|
Follicle, Dilatation | 2 2 | 3 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Chronic | 1 1 2 1 2 2 1 1 2 2 2 2 2 2 2 | 44 1.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + M + + + + + | 68 |
Inflammation, Chronic | 1 1 | 5 1.0|
Inflammation, Suppurative | 2 1 2 2 1 1 1 | 23 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + M + + + + + | 69 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 70 |
Necrosis, Coagulative | | 1 4.0|
Interstitial Cell, Hyperplasia | 2 2 | 4 2.0|
Seminiferous Tubule, Atrophy | 4 4 4 4 | 12 4.0|
Seminiferous Tubule, Hypoplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 70 |
Mediastinal, Pigmentation, | | |
Hemosiderin | 1 | 1 1.0|
Mediastinal, Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + | 68 |
Infiltration Cellular, Histiocyte | | 7 1.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Depletion Lymphoid | | 1 3.0|
Fibrosis | 1 | 4 1.8|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 4| 7| 7| 5| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 2| 5| 3| 3| 5| 3| 5| 3| 7| 5| 0| 2| 0| 3| 2| 2| 1| 5| | |
| 0| 1| 5| 6| 1| 1| 6| 1| 6| 1| 0| 6| 9| 9| 8| 1| 9| 9| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + | 62 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M M + + + + M + M + M M + + + + M M | 50 |
Hyperplasia, Cystic | 1 2 1 2 | 17 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 69 |
Abscess | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Femur, Fibrous Osteodystrophy | X | 4 |
Synovial Tissue, Inflammation, | | |
Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Gliosis | | 1 4.0|
Infarct | 3 | 3 2.7|
Hypothalamus, Compression | 2 | 4 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Bronchus, Foreign Body, Single | | 1 1.0|
Bronchus, Epithelium, Hyperplasia, | | |
Multifocal | | 1 1.0|
Interstitium, Inflammation, Chronic | 2 | 2 2.0|
Interstitium, Mineralization | | 2 2.0|
Peribronchiolar, Inflammation, | | |
Chronic, Multifocal | | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Fungus | X | 1 |
Nares, Inflammation, Suppurative | 2 2 | 3 2.0|
Sinus, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Middle Ear, Abscess | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 4| 7| 7| 4| 7| 4| 7| 4| 4| 7| 7| 5| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 2| 5| 3| 3| 5| 3| 5| 3| 7| 5| 0| 2| 0| 3| 2| 2| 1| 5| | |
| 0| 1| 5| 6| 1| 1| 6| 1| 6| 1| 0| 6| 9| 9| 8| 1| 9| 9| 7| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Phthisis Bulbi | X | 1 |
Cornea, Mineralization | | 1 2.0|
Lens, Cataract | 2 | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Inflammation, Chronic, Multifocal | | 2 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | | 1 |
Hydronephrosis | | 1 1.0|
Inflammation, Suppurative | | 1 3.0|
Nephropathy | 2 3 4 2 2 2 2 1 3 2 1 2 1 1 2 2 | 47 2.5|
Nephropathy, Multifocal | 1 1 1 1 | 10 1.0|
Interstitial Tissue, Inflammation, | | |
Chronic, Multifocal | | 4 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + | 69 |
Inflammation, Necrotizing | | 1 4.0|
Inflammation, Suppurative | 3 | 1 3.0|
Lumen, Hemorrhage | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 0| 6| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 0| 7| 7| 7| 6| 0| 3|
DAY ON TEST | 1| 1| 2| 5| 7| 9| 1| 2| 5| 2| 0| 2| 1| 7| 2| 3| 3| 5| 9| 0| 3| 3| 5| 9| 2|
| 5| 3| 2| 6| 4| 4| 0| 9| 6| 9| 2| 9| 1| 4| 9| 0| 0| 6| 6| 2| 0| 0| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + M|
Edema | 3 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X |
Clear Cell Focus | |
Degeneration, Cystic | 1 1 1 1 1 1 |
Eosinophilic Focus | |
Fatty Change | 3 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 3 |
Mixed Cell Focus | X |
Necrosis, Coagulative | |
Sinusoid, Congestion | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 2 1 1 2 |
Artery, Inflammation, Chronic | 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
Ulcer | 4 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Mucosa, Mineralization | 4 |
__________________________________________________________________________|
Tooth | + |
Pulp, Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 0| 6| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 0| 7| 7| 7| 6| 0| 3|
DAY ON TEST | 1| 1| 2| 5| 7| 9| 1| 2| 5| 2| 0| 2| 1| 7| 2| 3| 3| 5| 9| 0| 3| 3| 5| 9| 2|
| 5| 3| 2| 6| 4| 4| 0| 9| 6| 9| 2| 9| 1| 4| 9| 0| 0| 6| 6| 2| 0| 0| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 2 3 2 3 2 2 2 4 1 3 2 1 2 3 3 4 |
Myocardium, Degeneration, Multifocal | 2 2 2 |
Myocardium, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Ectopic Tissue | |
Hyperplasia | 1 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 4 1 3 |
Infarct | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 3 2 2 2 2 2 3 3 3 2 1 |
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | 1|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 3 1 1 3 2 1 2 1 2 2 1 1 2 1 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + +|
Inflammation, Suppurative | 2 1 1 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + M + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 0| 6| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 0| 7| 7| 7| 6| 0| 3|
DAY ON TEST | 1| 1| 2| 5| 7| 9| 1| 2| 5| 2| 0| 2| 1| 7| 2| 3| 3| 5| 9| 0| 3| 3| 5| 9| 2|
| 5| 3| 2| 6| 4| 4| 0| 9| 6| 9| 2| 9| 1| 4| 9| 0| 0| 6| 6| 2| 0| 0| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Sinus, Ectasia | 2 |
Renal, Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
Infiltration Cellular, Mononuclear | |
Cell | |
Sinus, Ectasia | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Infarct | 3 |
__________________________________________________________________________|
Thymus | + + + M + + + M M + + + + + + + + + +|
Atrophy | |
Ectopic Parathyroid Gland | X |
Ectopic Thyroid | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M M + M + + + + + + M + + M +|
Hyperplasia, Cystic | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst Epithelial Inclusion | X |
Ulcer | 2 |
Epidermis, Acanthosis | 2 |
Epidermis, Hyperkeratosis | 4 |
Hair Follicle, Hyperkeratosis | 3|
Sebaceous Gland, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 0| 6| 7| 4| 7| 7| 7| 6| 6| 7| 7| 7| 4| 0| 7| 7| 7| 6| 0| 3|
DAY ON TEST | 1| 1| 2| 5| 7| 9| 1| 2| 5| 2| 0| 2| 1| 7| 2| 3| 3| 5| 9| 0| 3| 3| 5| 9| 2|
| 5| 3| 2| 6| 4| 4| 0| 9| 6| 9| 2| 9| 1| 4| 9| 0| 0| 6| 6| 2| 0| 0| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
150 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Hypothalamus, Compression | 3 4 1 2 |
__________________________________________________________________________|
Spinal Cord | |
Lumbar, Atrophy | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Interstitium, Inflammation, Chronic | |
Interstitium, Mineralization | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 4 |
Sclera, Mineralization | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 3 4 4 3 1 1 3 3 3 3 2 4 3 4 3 2 4 3 1|
Nephropathy, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 0| 4| 5| 6| 0| 4| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 7| 0| 4| 6|
DAY ON TEST | 4| 1| 6| 2| 1| 9| 5| 3| 1| 9| 5| 3| 3| 5| 3| 5| 3| 3| 3| 2| 6| 2| 9| 5| 4|
| 2| 1| 0| 9| 0| 5| 6| 9| 9| 4| 6| 0| 0| 9| 0| 6| 0| 0| 1| 9| 6| 9| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + +|
Edema | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X |
Clear Cell Focus | X X X X X |
Degeneration, Cystic | 1 |
Eosinophilic Focus | |
Fatty Change | 3 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 4 |
Mixed Cell Focus | X X X |
Necrosis, Coagulative | 4 1 |
Sinusoid, Congestion | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 2|
Artery, Inflammation, Chronic | 1 2 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 2 1 2|
Mucosa, Mineralization | 2 |
__________________________________________________________________________|
Tooth | |
Pulp, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 0| 4| 5| 6| 0| 4| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 7| 0| 4| 6|
DAY ON TEST | 4| 1| 6| 2| 1| 9| 5| 3| 1| 9| 5| 3| 3| 5| 3| 5| 3| 3| 3| 2| 6| 2| 9| 5| 4|
| 2| 1| 0| 9| 0| 5| 6| 9| 9| 4| 6| 0| 0| 9| 0| 6| 0| 0| 1| 9| 6| 9| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 2 3 2 2 3 2 1 3 2 1 2 2 3 3 2 3 1|
Myocardium, Degeneration, Multifocal | 1 2 1 |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Ectopic Tissue | |
Hyperplasia | 1 2 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1|
Infarct | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 1 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 3 2 2 2 2 2 3 2 1 1|
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
Inflammation, Chronic | 1 1 4 1 1 1 2 1 1 2 2 2 |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1 1 4 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 0| 4| 5| 6| 0| 4| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 7| 0| 4| 6|
DAY ON TEST | 4| 1| 6| 2| 1| 9| 5| 3| 1| 9| 5| 3| 3| 5| 3| 5| 3| 3| 3| 2| 6| 2| 9| 5| 4|
| 2| 1| 0| 9| 0| 5| 6| 9| 9| 4| 6| 0| 0| 9| 0| 6| 0| 0| 1| 9| 6| 9| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 4 4 4 4 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Mediastinal, Sinus, Ectasia | |
Renal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Plasma Cell | |
Infiltration Cellular, Mononuclear | |
Cell | 2 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | |
Infarct | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectopic Parathyroid Gland | |
Ectopic Thyroid | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + + + + + + + + M + + + + + + M +|
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Cyst Epithelial Inclusion | X X |
Ulcer | |
Epidermis, Acanthosis | |
Epidermis, Hyperkeratosis | |
Hair Follicle, Hyperkeratosis | |
Sebaceous Gland, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 0| 4| 5| 6| 0| 4| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 7| 0| 4| 6|
DAY ON TEST | 4| 1| 6| 2| 1| 9| 5| 3| 1| 9| 5| 3| 3| 5| 3| 5| 3| 3| 3| 2| 6| 2| 9| 5| 4|
| 2| 1| 0| 9| 0| 5| 6| 9| 9| 4| 6| 0| 0| 9| 0| 6| 0| 0| 1| 9| 6| 9| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
150 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Infarct | |
Hypothalamus, Compression | |
__________________________________________________________________________|
Spinal Cord | + |
Lumbar, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Interstitium, Inflammation, Chronic | 1 |
Interstitium, Mineralization | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Sclera, Mineralization | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 1 2 2 4 2 1 2 3 2 2 3 3 3 4 1 4 2|
Nephropathy, Multifocal | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 0| 7| 6| 0| 4| 0| 0| 4| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| | |
DAY ON TEST | 9| 3| 5| 9| 5| 9| 9| 5| 1| 5| 3| 3| 8| 3| 2| 3| 1| 3| 3| 5| | |
| 4| 1| 2| 6| 6| 4| 3| 6| 0| 6| 1| 1| 3| 1| 9| 1| 7| 1| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + | 49 |
Edema | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + | 51 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + | 48 |
Edema | | 1 3.0|
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + | 50 |
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + | 50 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 56 |
Angiectasis, Focal | 3 2 | 2 2.5|
Basophilic Focus | X X X X X | 14 |
Clear Cell Focus | X | 6 |
Degeneration, Cystic | | 7 1.0|
Eosinophilic Focus | X X X | 3 |
Fatty Change | | 2 3.0|
Hepatodiaphragmatic Nodule | X | 4 |
Hyperplasia | 2 | 3 3.0|
Mixed Cell Focus | X X | 6 |
Necrosis, Coagulative | | 2 2.5|
Sinusoid, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + | 51 |
Acinus, Atrophy | 1 1 1 1 1 1 | 19 1.2|
Artery, Inflammation, Chronic | | 6 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + | 51 |
Inflammation, Chronic | | 2 2.0|
Ulcer | 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + | 51 |
Ulcer | 3 3 | 6 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 0| 7| 6| 0| 4| 0| 0| 4| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| | |
DAY ON TEST | 9| 3| 5| 9| 5| 9| 9| 5| 1| 5| 3| 3| 8| 3| 2| 3| 1| 3| 3| 5| | |
| 4| 1| 2| 6| 6| 4| 3| 6| 0| 6| 1| 1| 3| 1| 9| 1| 7| 1| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Mineralization | 4 | 3 3.3|
__________________________________________________________________________|____________|
Tooth | | 1 |
Pulp, Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
Aorta, Mineralization | 3 | 3 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + | 60 |
Myocardium, Degeneration | 2 3 3 2 2 1 1 3 1 2 3 | 44 2.3|
Myocardium, Degeneration, Multifocal | 1 | 7 1.6|
Myocardium, Mineralization | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + | 51 |
Angiectasis | | 1 2.0|
Ectopic Tissue | X | 1 |
Hyperplasia | 1 2 2 2 | 14 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + | 51 |
Hyperplasia | 1 2 2 1 3 | 14 2.1|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + | 47 |
Hyperplasia | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + | 52 |
Pars Distalis, Cyst | X | 2 |
Pars Distalis, Hyperplasia | 2 2 3 | 5 2.2|
Pars Intermedia, Cyst | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 3 2 3 3 2 1 2 | 32 2.1|
Follicle, Dilatation | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + | 51 |
Granuloma Sperm | 3 | 1 3.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 0| 7| 6| 0| 4| 0| 0| 4| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| | |
DAY ON TEST | 9| 3| 5| 9| 5| 9| 9| 5| 1| 5| 3| 3| 8| 3| 2| 3| 1| 3| 3| 5| | |
| 4| 1| 2| 6| 6| 4| 3| 6| 0| 6| 1| 1| 3| 1| 9| 1| 7| 1| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + | 51 |
Hyperplasia | | 3 2.3|
Inflammation, Chronic | 2 1 2 2 1 1 2 2 2 2 1 2 1 | 39 1.6|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + M + + + + + + + + + + + | 49 |
Inflammation, Suppurative | 1 3 1 1 1 | 17 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + M + + + + + + + + + + + | 48 |
Inflammation, Suppurative | 3 | 2 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + | 51 |
Interstitial Cell, Hyperplasia | | 1 2.0|
Seminiferous Tubule, Atrophy | 3 4 4 4 4 | 15 3.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 51 |
Mediastinal, Sinus, Ectasia | | 1 2.0|
Renal, Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + | 50 |
Hyperplasia, Plasma Cell | 2 | 2 2.0|
Sinus, Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + | 48 |
Hyperplasia, Plasma Cell | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
Sinus, Ectasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + | 51 |
Fibrosis | 3 2 | 6 2.2|
Hematopoietic Cell Proliferation | | 2 2.5|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Infarct | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + | 47 |
Atrophy | | 1 3.0|
Ectopic Parathyroid Gland | | 1 |
Ectopic Thyroid | X | 1 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M + + + + M + + + + M | 38 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 0| 7| 6| 0| 4| 0| 0| 4| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| | |
DAY ON TEST | 9| 3| 5| 9| 5| 9| 9| 5| 1| 5| 3| 3| 8| 3| 2| 3| 1| 3| 3| 5| | |
| 4| 1| 2| 6| 6| 4| 3| 6| 0| 6| 1| 1| 3| 1| 9| 1| 7| 1| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Cystic | 1 | 5 1.8|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + | 51 |
Abscess | 3 | 2 2.5|
Cyst Epithelial Inclusion | | 3 |
Ulcer | | 1 2.0|
Epidermis, Acanthosis | | 1 2.0|
Epidermis, Hyperkeratosis | | 1 4.0|
Hair Follicle, Hyperkeratosis | | 1 3.0|
Sebaceous Gland, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 51 |
Femur, Fibrous Osteodystrophy | X | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + | 51 |
Infarct | | 1 3.0|
Hypothalamus, Compression | | 4 2.5|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Lumbar, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + | 51 |
Interstitium, Inflammation, Chronic | 1 | 2 1.0|
Interstitium, Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 1 4.0|
Sclera, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + | 51 |
Cyst | | 2 |
Nephropathy | 3 3 4 3 3 4 3 4 3 2 3 3 2 | 49 2.8|
Nephropathy, Multifocal | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 0| 7| 6| 0| 4| 0| 0| 4| 7| 4| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| | |
DAY ON TEST | 9| 3| 5| 9| 5| 9| 9| 5| 1| 5| 3| 3| 8| 3| 2| 3| 1| 3| 3| 5| | |
| 4| 1| 2| 6| 6| 4| 3| 6| 0| 6| 1| 1| 3| 1| 9| 1| 7| 1| 1| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
150 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + M + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 6| 4| 0| 5| 7| 7| 7| 6| 7| 0| 5| 4| 4| 6| 5| 7| 7| 7| 6| 7| 6| 7| 0|
DAY ON TEST | 0| 5| 8| 5| 9| 5| 1| 2| 2| 9| 2| 9| 9| 5| 5| 1| 3| 2| 3| 3| 2| 2| 9| 2| 9|
| 5| 6| 0| 6| 4| 2| 8| 9| 9| 3| 9| 6| 2| 6| 6| 7| 1| 9| 0| 0| 6| 6| 1| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + |
Dilatation | |
__________________________________________________________________________|
Intestine Large | + + + + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + |
Bacterium | X |
Basophilic Focus | X X X |
Clear Cell Focus | X X |
Degeneration, Cystic | 1 1 1 1 1 1 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 4 |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X X X X X |
Necrosis, Coagulative | 2 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + |
Ectopic Tissue | X |
Acinus, Atrophy | 1 2 2 1 1 |
Artery, Inflammation, Chronic | 3 1 3 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + |
Periductular, Fibrosis | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + |
Acanthosis | 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic | 2 |
Mineralization | 1 |
Ulcer | |
Epithelium, Hyperkeratosis, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Ulcer | 2 2 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 6| 4| 0| 5| 7| 7| 7| 6| 7| 0| 5| 4| 4| 6| 5| 7| 7| 7| 6| 7| 6| 7| 0|
DAY ON TEST | 0| 5| 8| 5| 9| 5| 1| 2| 2| 9| 2| 9| 9| 5| 5| 1| 3| 2| 3| 3| 2| 2| 9| 2| 9|
| 5| 6| 0| 6| 4| 2| 8| 9| 9| 3| 9| 6| 2| 6| 6| 7| 1| 9| 0| 0| 6| 6| 1| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Mineralization | 4 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + |
Atrium, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic | 2 |
Myocardium, Degeneration | 3 3 2 3 3 2 2 2 2 1 2 2 2 3 2 1 |
Myocardium, Degeneration, Multifocal | 1 2 1 |
Myocardium, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 4 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + |
Pars Distalis, Hyperplasia | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 1 3 3 2 2 2 2 2 2 3 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 3 |
Inflammation, Chronic | 1 1 1 2 1 2 1 2 1 2 3 1 2 4 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + |
Cyst | X |
Inflammation, Suppurative | 1 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 6| 4| 0| 5| 7| 7| 7| 6| 7| 0| 5| 4| 4| 6| 5| 7| 7| 7| 6| 7| 6| 7| 0|
DAY ON TEST | 0| 5| 8| 5| 9| 5| 1| 2| 2| 9| 2| 9| 9| 5| 5| 1| 3| 2| 3| 3| 2| 2| 9| 2| 9|
| 5| 6| 0| 6| 4| 2| 8| 9| 9| 3| 9| 6| 2| 6| 6| 7| 1| 9| 0| 0| 6| 6| 1| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 |
Renal, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Histiocyte | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Infarct | 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + M M + M + M + + M M M |
Hyperplasia, Cystic | 1 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Abscess | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + |
Femur, Fibrous Osteodystrophy | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + |
Infarct | 2 4 |
Hypothalamus, Compression | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Alveolus, Inflammation, Subacute | |
Interstitium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 4| 6| 4| 0| 5| 7| 7| 7| 6| 7| 0| 5| 4| 4| 6| 5| 7| 7| 7| 6| 7| 6| 7| 0|
DAY ON TEST | 0| 5| 8| 5| 9| 5| 1| 2| 2| 9| 2| 9| 9| 5| 5| 1| 3| 2| 3| 3| 2| 2| 9| 2| 9|
| 5| 6| 0| 6| 4| 2| 8| 9| 9| 3| 9| 6| 2| 6| 6| 7| 1| 9| 0| 0| 6| 6| 1| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Mineralization | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + |
Nares, Foreign Body | |
Nares, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Necrotizing | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + |
Cyst | |
Nephropathy | 4 4 2 2 3 3 2 4 3 2 2 3 3 3 3 4 4 4 |
Nephropathy, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + |
Ectasia | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 0| 7| 4| 4| 6| 7| 7| 4| 0| 0| 6| 0| 7| 7| 5| 6| 4| 7| 0| 7| 0|
DAY ON TEST | 2| 2| 3| 3| 9| 3| 5| 5| 7| 3| 1| 5| 9| 9| 9| 9| 3| 1| 7| 6| 5| 0| 9| 0| 9|
| 6| 9| 0| 0| 3| 0| 6| 6| 1| 0| 9| 6| 6| 5| 8| 4| 1| 3| 2| 8| 6| 2| 6| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + |
Dilatation | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + |
Bacterium | |
Basophilic Focus | X |
Clear Cell Focus | X X |
Degeneration, Cystic | 2 1 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 3 |
Inflammation, Granulomatous | 1 1 1 |
Mixed Cell Focus | X |
Necrosis, Coagulative | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + |
Ectopic Tissue | |
Acinus, Atrophy | 1 1 2 1 1 1 |
Artery, Inflammation, Chronic | 1 2 3 3 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + |
Periductular, Fibrosis | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Acanthosis | 2 |
Hyperkeratosis | 2 |
Inflammation, Chronic | |
Mineralization | |
Ulcer | |
Epithelium, Hyperkeratosis, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 0| 7| 4| 4| 6| 7| 7| 4| 0| 0| 6| 0| 7| 7| 5| 6| 4| 7| 0| 7| 0|
DAY ON TEST | 2| 2| 3| 3| 9| 3| 5| 5| 7| 3| 1| 5| 9| 9| 9| 9| 3| 1| 7| 6| 5| 0| 9| 0| 9|
| 6| 9| 0| 0| 3| 0| 6| 6| 1| 0| 9| 6| 6| 5| 8| 4| 1| 3| 2| 8| 6| 2| 6| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Mineralization | 3 3 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Atrium, Thrombosis | |
Coronary Artery, Inflammation, | |
Chronic | |
Myocardium, Degeneration | 3 2 2 3 1 2 3 2 2 1 2 1 |
Myocardium, Degeneration, Multifocal | 1 1 |
Myocardium, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + |
Hyperplasia | 1 1 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 2 2 1 2 4 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + |
Hyperplasia | 2 3 4 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + |
Pars Distalis, Hyperplasia | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia | 2 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + |
Hyperplasia | 3 |
Inflammation, Chronic | 1 1 1 2 2 3 3 2 3 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + |
Cyst | |
Inflammation, Suppurative | 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 0| 7| 4| 4| 6| 7| 7| 4| 0| 0| 6| 0| 7| 7| 5| 6| 4| 7| 0| 7| 0|
DAY ON TEST | 2| 2| 3| 3| 9| 3| 5| 5| 7| 3| 1| 5| 9| 9| 9| 9| 3| 1| 7| 6| 5| 0| 9| 0| 9|
| 6| 9| 0| 0| 3| 0| 6| 6| 1| 0| 9| 6| 6| 5| 8| 4| 1| 3| 2| 8| 6| 2| 6| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + |
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 3 4 4 4 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Renal, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + |
Infiltration Cellular, Histiocyte | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Fibrosis | 1 2 |
Hematopoietic Cell Proliferation | 1 |
Infarct | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + M |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + M + + + + + + + + + |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Abscess | 3 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + |
Femur, Fibrous Osteodystrophy | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
Infarct | 3 2 |
Hypothalamus, Compression | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + |
Alveolus, Inflammation, Subacute | 2 |
Interstitium, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 0| 7| 4| 4| 6| 7| 7| 4| 0| 0| 6| 0| 7| 7| 5| 6| 4| 7| 0| 7| 0|
DAY ON TEST | 2| 2| 3| 3| 9| 3| 5| 5| 7| 3| 1| 5| 9| 9| 9| 9| 3| 1| 7| 6| 5| 0| 9| 0| 9|
| 6| 9| 0| 0| 3| 0| 6| 6| 1| 0| 9| 6| 6| 5| 8| 4| 1| 3| 2| 8| 6| 2| 6| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Interstitium, Mineralization | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + |
Nares, Foreign Body | 2 |
Nares, Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + |
Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Necrotizing | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Cyst | |
Nephropathy | 4 3 3 3 4 2 2 3 4 3 4 3 3 3 3 |
Nephropathy, Multifocal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + |
Ectasia | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 0| 6| 6| 6| 7| 6| 6| 5| 7| 4| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6| | |
DAY ON TEST | 9| 9| 7| 4| 2| 6| 8| 3| 0| 5| 3| 3| 9| 7| 3| 3| 3| 5| 4| 3| | |
| 4| 3| 2| 9| 9| 6| 8| 9| 1| 6| 1| 1| 4| 0| 1| 1| 1| 6| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
300 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 50 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + M + + + + + + + + + + + + + | 48 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 49 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 50 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + | 55 |
Bacterium | | 1 |
Basophilic Focus | X | 5 |
Clear Cell Focus | X | 5 |
Degeneration, Cystic | 1 1 | 10 1.1|
Eosinophilic Focus | X X | 2 |
Hepatodiaphragmatic Nodule | X X | 4 |
Hyperplasia | 3 2 3 | 5 3.0|
Inflammation, Granulomatous | 2 | 5 1.2|
Mixed Cell Focus | X X X | 9 |
Necrosis, Coagulative | 3 | 4 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Fat, Necrosis | 3 | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + | 50 |
Ectopic Tissue | | 1 |
Acinus, Atrophy | 1 1 1 1 1 1 | 17 1.2|
Artery, Inflammation, Chronic | 2 2 | 11 2.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 50 |
Periductular, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 51 |
Acanthosis | 2 | 3 2.0|
Hyperkeratosis | 2 | 3 2.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 0| 6| 6| 6| 7| 6| 6| 5| 7| 4| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6| | |
DAY ON TEST | 9| 9| 7| 4| 2| 6| 8| 3| 0| 5| 3| 3| 9| 7| 3| 3| 3| 5| 4| 3| | |
| 4| 3| 2| 9| 9| 6| 8| 9| 1| 6| 1| 1| 4| 0| 1| 1| 1| 6| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
300 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 2 2 | 2 2.0|
Epithelium, Hyperkeratosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 2 2 | 4 2.0|
Mucosa, Mineralization | 3 3 1 | 7 2.7|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
Aorta, Mineralization | 3 | 3 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + | 60 |
Atrium, Thrombosis | X | 1 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 2.0|
Myocardium, Degeneration | 3 3 4 2 2 2 2 3 3 2 1 2 2 3 | 42 2.2|
Myocardium, Degeneration, Multifocal | 2 | 6 1.3|
Myocardium, Mineralization | 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia | 1 2 1 3 3 1 1 | 18 1.4|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia | 1 3 1 | 16 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia | 3 2 4 3 | 11 2.7|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 49 |
Pars Distalis, Hyperplasia | 1 2 1 | 7 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | 3 2 3 2 2 1 2 1 2 | 28 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 0| 6| 6| 6| 7| 6| 6| 5| 7| 4| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6| | |
DAY ON TEST | 9| 9| 7| 4| 2| 6| 8| 3| 0| 5| 3| 3| 9| 7| 3| 3| 3| 5| 4| 3| | |
| 4| 3| 2| 9| 9| 6| 8| 9| 1| 6| 1| 1| 4| 0| 1| 1| 1| 6| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
300 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + | 51 |
Hyperplasia | | 3 2.7|
Inflammation, Chronic | 2 2 2 3 1 1 2 2 2 2 2 2 1 2 | 40 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + | 50 |
Cyst | | 1 |
Inflammation, Suppurative | 3 2 1 2 | 13 1.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + | 56 |
Interstitial Cell, Hyperplasia | 1 | 1 1.0|
Seminiferous Tubule, Atrophy | 4 4 4 2 4 | 12 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + | 50 |
Mediastinal, Pigmentation, | | |
Hemosiderin | | 1 2.0|
Renal, Ectasia | 4 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + | 50 |
Hyperplasia, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + M + + + + + + + + + | 47 |
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Sinus, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 50 |
Fibrosis | 2 2 | 4 1.8|
Hematopoietic Cell Proliferation | | 1 1.0|
Infarct | | 1 2.0|
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + + + | 46 |
Artery, Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + M + + M + + + + + + + + M | 35 |
Hyperplasia, Cystic | 2 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 50 |
Abscess | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 0| 6| 6| 6| 7| 6| 6| 5| 7| 4| 7| 7| 6| 6| 7| 7| 7| 4| 5| 6| | |
DAY ON TEST | 9| 9| 7| 4| 2| 6| 8| 3| 0| 5| 3| 3| 9| 7| 3| 3| 3| 5| 4| 3| | |
| 4| 3| 2| 9| 9| 6| 8| 9| 1| 6| 1| 1| 4| 0| 1| 1| 1| 6| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
300 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + | 50 |
Femur, Fibrous Osteodystrophy | X X | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 50 |
Infarct | 3 3 | 6 2.8|
Hypothalamus, Compression | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 50 |
Alveolus, Inflammation, Subacute | | 1 2.0|
Interstitium, Inflammation, Chronic | 1 2 | 3 1.3|
Interstitium, Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 50 |
Nares, Foreign Body | | 1 2.0|
Nares, Inflammation, Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 50 |
Inflammation, Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cornea, Inflammation, Necrotizing | 4 | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + | 52 |
Cyst | X X | 2 |
Nephropathy | 4 4 4 4 3 2 1 3 4 2 2 2 3 3 4 1 4 | 50 3.0|
Nephropathy, Multifocal | 1 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 50 |
Ectasia | 4 | 1 4.0|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 0| 0| 7| 6| 7| 0| 0| 7| 7| 5| 7| 0| 5| 5| 5| 4| 0| 4| 4| 7| 5| 0| 7| 6| 4|
DAY ON TEST | 9| 9| 2| 8| 2| 9| 9| 2| 0| 8| 1| 9| 4| 0| 2| 5| 9| 5| 5| 3| 5| 9| 0| 8| 5|
| 3| 6| 9| 0| 9| 5| 3| 9| 9| 9| 2| 5| 2| 8| 2| 6| 5| 6| 6| 1| 8| 5| 3| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + M + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X X X X|
Clear Cell Focus | X X |
Degeneration, Cystic | 1 1 1 |
Eosinophilic Focus | X X X X X X |
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 3 3 2 2 4 |
Inflammation, Granulomatous | |
Mixed Cell Focus | X X X X X X |
Necrosis, Coagulative | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 3 |
Pigmentation, Hemosiderin | 2 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Acinus, Atrophy | 1 2 1 |
Artery, Inflammation, Chronic | 4 1 1 2 |
Duct, Ectasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Parotid Gland, Cytoplasmic | |
Alteration, Focal | |
Acinus, Parotid Gland, Vacuolization | |
Cytoplasmic, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 3 |
Hyperkeratosis | 2 2 3 |
Inflammation, Chronic | 2 2 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 0| 0| 7| 6| 7| 0| 0| 7| 7| 5| 7| 0| 5| 5| 5| 4| 0| 4| 4| 7| 5| 0| 7| 6| 4|
DAY ON TEST | 9| 9| 2| 8| 2| 9| 9| 2| 0| 8| 1| 9| 4| 0| 2| 5| 9| 5| 5| 3| 5| 9| 0| 8| 5|
| 3| 6| 9| 0| 9| 5| 3| 9| 9| 9| 2| 5| 2| 8| 2| 6| 5| 6| 6| 1| 8| 5| 3| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Mucosa, Mineralization | 4 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic, Focal | 1 |
Aorta, Inflammation, Chronic | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 1 3 2 3 2 1 1 2 3 |
Myocardium, Degeneration, Multifocal | 2 1 2 3|
Myocardium, Inflammation, Chronic, | |
Multifocal | 1 1 1 |
Myocardium, Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + M + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 |
Pars Distalis, Hyperplasia, Nodular | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 3 3 2 1 3 2 1 1 2 1 2 1 3 1|
Follicle, Dilatation | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Chronic | 2 2 2 3 2 2 1 1 1 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 0| 0| 7| 6| 7| 0| 0| 7| 7| 5| 7| 0| 5| 5| 5| 4| 0| 4| 4| 7| 5| 0| 7| 6| 4|
DAY ON TEST | 9| 9| 2| 8| 2| 9| 9| 2| 0| 8| 1| 9| 4| 0| 2| 5| 9| 5| 5| 3| 5| 9| 0| 8| 5|
| 3| 6| 9| 0| 9| 5| 3| 9| 9| 9| 2| 5| 2| 8| 2| 6| 5| 6| 6| 1| 8| 5| 3| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
Interstitial Cell, Right, Hyperplasia| |
Seminiferous Tubule, Atrophy | 4 4 4 |
Seminiferous Tubule, Right, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + M + + + + + + + +|
Infiltration Cellular, Histiocyte | 3 2 3 2 1 |
Sinus, Ectasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Infarct | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M M +|
Arteriole, Giant Cell | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + M + + + + M + M M + + + + + +|
Hyperplasia, Cystic | 3 1 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage | |
Epidermis, Acanthosis | |
Epidermis, Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | |
Femur, Fibrous Osteodystrophy | X |
Femur, Osteopetrosis | 3 |
Synovial Tissue, Inflammation, | |
Suppurative | |
Tarsal, Fracture Healed | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 0| 0| 7| 6| 7| 0| 0| 7| 7| 5| 7| 0| 5| 5| 5| 4| 0| 4| 4| 7| 5| 0| 7| 6| 4|
DAY ON TEST | 9| 9| 2| 8| 2| 9| 9| 2| 0| 8| 1| 9| 4| 0| 2| 5| 9| 5| 5| 3| 5| 9| 0| 8| 5|
| 3| 6| 9| 0| 9| 5| 3| 9| 9| 9| 2| 5| 2| 8| 2| 6| 5| 6| 6| 1| 8| 5| 3| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 3 |
Infarct | 3 |
Inflammation, Suppurative | 3 |
Hypothalamus, Compression | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Alveolus, Hemorrhage, Multifocal | 2 |
Alveolus, Inflammation, Subacute | 2 |
Artery, Mineralization, Focal | 1 |
Interstitium, Inflammation, Chronic, | |
Focal | |
Interstitium, Inflammation, Chronic | 1 |
Peribronchial, Inflammation, Chronic,| |
Focal | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Nares, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Cornea, Mineralization | 1 |
Lens, Cataract | 4 |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 4 4 3 4 4 2 4 1 1 1 4 1 2 4 |
Nephropathy, Multifocal | 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 0| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 5| 7| 7| 0| 6| 4|
DAY ON TEST | 2| 9| 5| 3| 3| 4| 2| 3| 3| 3| 5| 3| 3| 3| 2| 5| 6| 1| 3| 1| 3| 2| 9| 7| 5|
| 9| 4| 6| 0| 4| 5| 9| 0| 0| 0| 6| 0| 0| 0| 9| 6| 8| 5| 0| 9| 0| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + A + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
Edema | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 4 |
Basophilic Focus | X X X X X X X X X X|
Clear Cell Focus | X X X X |
Degeneration, Cystic | 1 1 1 1 |
Eosinophilic Focus | X X |
Fibrosis, Focal | 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia | 4 3 4 3 |
Inflammation, Granulomatous | 1 1 |
Mixed Cell Focus | X X X X |
Necrosis, Coagulative | 1 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Chronic | 3 |
Pigmentation, Hemosiderin | |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Acinus, Atrophy | 1 1 1 1 1 1 1 1 |
Artery, Inflammation, Chronic | 1 1 1 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Parotid Gland, Cytoplasmic | |
Alteration, Focal | 1 |
Acinus, Parotid Gland, Vacuolization | |
Cytoplasmic, Focal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 0| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 5| 7| 7| 0| 6| 4|
DAY ON TEST | 2| 9| 5| 3| 3| 4| 2| 3| 3| 3| 5| 3| 3| 3| 2| 5| 6| 1| 3| 1| 3| 2| 9| 7| 5|
| 9| 4| 6| 0| 4| 5| 9| 0| 0| 0| 6| 0| 0| 0| 9| 6| 8| 5| 0| 9| 0| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 1 |
Mucosa, Mineralization | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | +|
Aorta, Inflammation, Chronic, Focal | |
Aorta, Inflammation, Chronic | 2|
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Degeneration | 3 3 2 3 3 3 3 3 3 3 2 4 2 1 1 |
Myocardium, Degeneration, Multifocal | 2 3 1 3|
Myocardium, Inflammation, Chronic, | |
Multifocal | |
Myocardium, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia | 1 4 |
Pars Distalis, Hyperplasia, Nodular | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 2 2 2 1 3 3 2 2 3 2 2 2 2 2 2 1|
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 2 2 2 1 2 1 2 2 4 1 2 1 2 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 0| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 5| 7| 7| 0| 6| 4|
DAY ON TEST | 2| 9| 5| 3| 3| 4| 2| 3| 3| 3| 5| 3| 3| 3| 2| 5| 6| 1| 3| 1| 3| 2| 9| 7| 5|
| 9| 4| 6| 0| 4| 5| 9| 0| 0| 0| 6| 0| 0| 0| 9| 6| 8| 5| 0| 9| 0| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Suppurative | 1 1 1 3 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + M + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Interstitial Cell, Right, Hyperplasia| |
Seminiferous Tubule, Atrophy | 4 |
Seminiferous Tubule, Right, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 |
Infarct | 4 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + M + M + + + + M + + + M M M M +|
Arteriole, Giant Cell | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + M + M + + + M + + + + M + + + + +|
Hyperplasia, Cystic | 1 2 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage | 1 |
Epidermis, Acanthosis | 3 |
Epidermis, Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteopetrosis | 2 |
Femur, Fibrous Osteodystrophy | |
Femur, Osteopetrosis | |
Synovial Tissue, Inflammation, | |
Suppurative | |
Tarsal, Fracture Healed | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
_____________________________________________________________________________________________________________________
| 7| 0| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 5| 7| 7| 0| 6| 4|
DAY ON TEST | 2| 9| 5| 3| 3| 4| 2| 3| 3| 3| 5| 3| 3| 3| 2| 5| 6| 1| 3| 1| 3| 2| 9| 7| 5|
| 9| 4| 6| 0| 4| 5| 9| 0| 0| 0| 6| 0| 0| 0| 9| 6| 8| 5| 0| 9| 0| 9| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
600 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Infarct | |
Inflammation, Suppurative | |
Hypothalamus, Compression | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 |
Alveolus, Hemorrhage, Multifocal | |
Alveolus, Inflammation, Subacute | |
Artery, Mineralization, Focal | |
Interstitium, Inflammation, Chronic, | |
Focal | |
Interstitium, Inflammation, Chronic | 2 2 2|
Peribronchial, Inflammation, Chronic,| |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Nares, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cornea, Mineralization | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Chronic, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 3 3 2 4 4 3 3 3 4 3 3 3 2 4 4 1 2 1 4 |
Nephropathy, Multifocal | 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + M + + + + + + + +|
Lumen, Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 0| 7| 7| | |
DAY ON TEST | 9| 1| 5| 3| 3| 6| 5| 3| 7| 3| 5| 3| 3| 3| 3| 0| 9| 9| 2| 2| | |
| 2| 6| 3| 1| 1| 8| 6| 1| 4| 1| 6| 1| 1| 1| 1| 2| 5| 4| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + | 66 |
Ulcer | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + | 68 |
Edema | | 1 3.0|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + M + + + + + + + + + + | 67 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + A + + + + + + + + + + + + + + | 68 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + | 66 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + + + + + + | 69 |
Angiectasis, Focal | | 1 4.0|
Basophilic Focus | X X X X X | 23 |
Clear Cell Focus | X X X X X | 11 |
Degeneration, Cystic | 1 | 8 1.0|
Eosinophilic Focus | X | 9 |
Fibrosis, Focal | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 3 |
Hyperplasia | 3 | 10 3.1|
Inflammation, Granulomatous | | 2 1.0|
Mixed Cell Focus | X X X X | 14 |
Necrosis, Coagulative | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Inflammation, Chronic | | 2 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
Fat, Necrosis | 4 3 | 5 3.0|
__________________________________________________________________________|____________|
Pancreas | + A + + + A + + + + + + + + + + + + + + | 68 |
Ectopic Tissue | | 1 |
Acinus, Atrophy | 1 1 1 1 1 1 | 17 1.1|
Artery, Inflammation, Chronic | 1 3 1 1 1 | 12 1.5|
Duct, Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + | 70 |
Acinus, Parotid Gland, Cytoplasmic | | |
Alteration, Focal | | 1 1.0|
Acinus, Parotid Gland, Vacuolization | | |
Cytoplasmic, Focal | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 0| 7| 7| | |
DAY ON TEST | 9| 1| 5| 3| 3| 6| 5| 3| 7| 3| 5| 3| 3| 3| 3| 0| 9| 9| 2| 2| | |
| 2| 6| 3| 1| 1| 8| 6| 1| 4| 1| 6| 1| 1| 1| 1| 2| 5| 4| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach | + + + + + A + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + | 69 |
Acanthosis | 2 | 4 2.3|
Hyperkeratosis | 2 | 4 2.3|
Inflammation, Chronic | | 2 2.0|
Ulcer | | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + | 68 |
Ulcer | | 3 1.7|
Mucosa, Mineralization | 3 3 2 | 4 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
Aorta, Inflammation, Chronic, Focal | | 1 1.0|
Aorta, Inflammation, Chronic | | 1 2.0|
Aorta, Mineralization | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + | 70 |
Myocardium, Degeneration | 1 1 2 2 2 3 1 2 2 2 2 2 | 36 2.2|
Myocardium, Degeneration, Multifocal | 2 1 | 10 2.0|
Myocardium, Inflammation, Chronic, | | |
Multifocal | | 3 1.0|
Myocardium, Mineralization | 3 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + | 70 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia | 1 1 2 2 1 3 2 | 14 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + | 69 |
Hyperplasia | 1 2 | 6 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + | 68 |
Hyperplasia | 1 4 3 | 8 2.4|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + | 69 |
Abscess | | 1 4.0|
Pars Distalis, Cyst | | 1 3.0|
Pars Distalis, Hyperplasia | 1 2 2 | 6 1.8|
Pars Distalis, Hyperplasia, Nodular | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 0| 7| 7| | |
DAY ON TEST | 9| 1| 5| 3| 3| 6| 5| 3| 7| 3| 5| 3| 3| 3| 3| 0| 9| 9| 2| 2| | |
| 2| 6| 3| 1| 1| 8| 6| 1| 4| 1| 6| 1| 1| 1| 1| 2| 5| 4| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 1 2 2 2 1 1 3 2 3 2 3 2 | 44 2.0|
Follicle, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + M + + + + + + + + + | 67 |
Inflammation, Chronic | 2 2 2 2 2 1 1 2 3 3 1 2 | 47 1.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + | 69 |
Inflammation, Chronic | | 1 1.0|
Inflammation, Suppurative | 1 1 1 1 2 1 1 | 22 1.2|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + | 69 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + | 69 |
Interstitial Cell, Hyperplasia | | 1 2.0|
Interstitial Cell, Right, Hyperplasia| 4 | 1 4.0|
Seminiferous Tubule, Atrophy | 4 4 4 | 7 4.0|
Seminiferous Tubule, Right, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + | 70 |
Hyperplasia, Histiocytic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + | 70 |
Mediastinal, Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + | 70 |
Sinus, Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + A + + + + + + + + + + + + + + | 67 |
Infiltration Cellular, Histiocyte | | 5 2.2|
Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + | 70 |
Fibrosis | 2 2 1 2 | 8 1.8|
Infarct | 4 | 4 3.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + | 60 |
Arteriole, Giant Cell | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + M + + + + + + + + + M | 57 |
Hyperplasia, Cystic | 3 | 8 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 0| 7| 7| | |
DAY ON TEST | 9| 1| 5| 3| 3| 6| 5| 3| 7| 3| 5| 3| 3| 3| 3| 0| 9| 9| 2| 2| | |
| 2| 6| 3| 1| 1| 8| 6| 1| 4| 1| 6| 1| 1| 1| 1| 2| 5| 4| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + | 68 |
Cyst Epithelial Inclusion | X | 1 |
Hemorrhage | | 1 1.0|
Epidermis, Acanthosis | | 1 3.0|
Epidermis, Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + | 70 |
Osteopetrosis | | 1 2.0|
Femur, Fibrous Osteodystrophy | X | 2 |
Femur, Osteopetrosis | | 1 3.0|
Synovial Tissue, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Tarsal, Fracture Healed | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + | 70 |
Hydrocephalus | | 1 3.0|
Infarct | 3 | 2 3.0|
Inflammation, Suppurative | | 1 3.0|
Hypothalamus, Compression | | 3 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Granulomatous | | 1 2.0|
Alveolus, Hemorrhage, Multifocal | | 1 2.0|
Alveolus, Inflammation, Subacute | 2 | 2 2.0|
Artery, Mineralization, Focal | | 1 1.0|
Interstitium, Inflammation, Chronic, | | |
Focal | 1 | 1 1.0|
Interstitium, Inflammation, Chronic | | 4 1.8|
Peribronchial, Inflammation, Chronic,| | |
Focal | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Fungus | X | 1 |
Nares, Inflammation, Suppurative | 2 | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05087-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRIAMTERENE Date: 04/25/97
Route: DOSED FEED Time: 15:56:08
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 7| 3| 4| 7| 6| 7| 4| 7| 7| 7| 7| 7| 6| 0| 7| 7| | |
DAY ON TEST | 9| 1| 5| 3| 3| 6| 5| 3| 7| 3| 5| 3| 3| 3| 3| 0| 9| 9| 2| 2| | |
| 2| 6| 3| 1| 1| 8| 6| 1| 4| 1| 6| 1| 1| 1| 1| 2| 5| 4| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
600 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Mineralization | | 1 1.0|
Lens, Cataract | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Chronic, Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + | 70 |
Cyst | X | 1 |
Nephropathy | 2 1 2 4 3 4 4 3 2 3 3 2 4 1 2 3 | 49 2.8|
Nephropathy, Multifocal | 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + | 67 |
Lumen, Hemorrhage | 1 | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
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